Digital Commons Network^™

Resilient Modulus Of Compacted Crushed Stone Aggregate Bases, Tommy C. Hopkins, Tony L. Beckham, Charlie Sun

Kentucky Transportation Center Research Report

In recent years, the American Association of State Highway Transportation Officials (AASHTO) has recommended the use of resilient modulus for characterizing highway materials for pavement design. This recommendation evolved as result of a trend in pavement design of using mechanistic models. Although much progress has been made in recent years in developing mathematical, mechanistic pavement design models, results obtained from those models are only as good as the material parameters used in the models. Resilient modulus of aggregate bases is an important parameter in the mechanistic models. The main goal of this study was to establish a simple and efficient …

Transcriptional Control Of Vascular Smooth Muscle Cell Proliferation By Peroxisome Proliferator-Activated Receptor-Γ: Therapeutic Implications For Cardiovascular Diseases, Florence Gizard, Dennis Bruemmer

Internal Medicine Faculty Publications

Proliferation of vascular smooth muscle cells (SMCs) is a critical process for the development of atherosclerosis and complications of procedures used to treat atherosclerotic diseases, including postangioplasty restenosis, vein graft failure, and transplant vasculopathy. Peroxisome proliferator-activated receptor (PPAR) gamma is a member of the nuclear hormone receptor superfamily and the molecular target for the thiazolidinediones (TZD), used clinically to treat insulin resistance in patients with type 2 diabetes. In addition to their efficacy to improve insulin sensitivity, TZD exert a broad spectrum of pleiotropic beneficial effects on vascular gene expression programs. In SMCs, PPARgamma is prominently upregulated during neointima formation …

Understanding Barriers For Adherence To Follow-Up Care For Abnormal Pap Tests, Katherine S. Eggleston, Ann L. Coker, Irene Prabhu Das, Suzanne T. Cordray, Kathryn J. Luchok

CRVAW Faculty Journal Articles

Objective: Approximately 4000 women annually will die from preventable and treatable cervical cancer. Failure to adhere to follow-up recommendations after an abnormal Pap test can lead to development of cervical cancer. This paper summarizes the body of literature on adherence to follow-up after an abnormal Pap test in order to facilitate development of interventions

to decrease morbidity and mortality due to cervical cancer.

Methods: We conducted a comprehensive search of published literature addressing risk factors for adherence or interventions to improve adherence following an abnormal Pap test as the outcome. We included peer-reviewed original research conducted in the …

The Battle Over Implied Preemption: Products Liability And The Fda, Mary J. Davis

Law Faculty Scholarly Articles

A mere five years ago, the Food and Drug Administration (the "FDA") began, for the first time in its 100-year history, to take the position that its prescription drug labeling regulations defeated the ability of injured plaintiffs to pursue common law tort claims based on the adequacy of the labeling. This position, radical to many and rational to others, places federal preemption of prescription drug labeling actions directly in the center of the debate over the proper roles of federal regulation and state tort laws in promoting product safety. The U.S. Supreme Court has contributed to this debate with several …

Southeastern Law Librarian Fall 2007, Seaall

Newsletters

No abstract provided.

A Comparison Of State Policies For Complying With The Endangered Species Act, Lenahan O'Connell, Ted Grossardt

Kentucky Transportation Center Research Report

In recent years the number of biological assessments (BAs) for the presence of endangered species conducted by KYTC has risen significantly. This was primarily due to new/additional restrictions imposed by the United States Fish and Wildlife Service (USFWS) in 2005. The most consequential restriction was the listing of the Indiana bat as potentially present in all Kentucky counties. Previously BAs for the Indiana bat were only conducted when a project occurred in a county in which the Indiana bat had been observed (a known occurrence). This study reviewed the policies of the states adjacent to Kentucky, as well as those …

Characterization Of The Equine 2'-5' Oligoadenylate Synthetase 1 (Oas1) And Ribonuclease L (Rnasel) Innate Immunity Genes, Jonathan J. Rios, Andrey A. Perelygin, Maureen T. Long, Teri L. Lear, Andrey A. Zharkikh, Margo A. Brinton, David L. Adelson

Veterinary Science Faculty Publications

BACKGROUND: The mammalian OAS/RNASEL pathway plays an important role in antiviral host defense. A premature stop-codon within the murine Oas1b gene results in the increased susceptibility of mice to a number of flaviviruses, including West Nile virus (WNV). Mutations in either the OAS1 or RNASEL genes may also modulate the outcome of WNV-induced disease or other viral infections in horses. Polymorphisms in the human OAS gene cluster have been previously utilized for case-control analysis of virus-induced disease in humans. No polymorphisms have yet been identified in either the equine OAS1 or RNASEL genes for use in similar case-control studies.

RESULTS: …

Analysis Of Procurement Processes And Development Of Recommendations For Intelligent Transportation Systems (Its) Procurements, Joseph D. Crabtree, Christopher W. Frost, Jennifer Walton, John Crossfield

Kentucky Transportation Center Research Report

Traditional state procurement processes are not well-suited to the procurement of Intelligent Transportation Systems (ITS). The objective of this study was to analyze Kentucky’s existing procurement processes, identify strengths and weaknesses of each, and develop recommendations for a revised process (or processes) that would meet the unique requirements of ITS procurements. Four existing processes were identified, studied, documented, and assessed. The study also looked at design-build processes, both in Kentucky and in other states. Recommendations were developed for statutory changes to improve Kentucky’s ability to procure ITS technologies and systems.

Evaluation Of Us 119 Pine Mountain Safety Improvements (Final Report), Jerry G. Pigman, Kenneth R. Agent

Kentucky Transportation Center Research Report

The Transportation Center at the University of Kentucky was requested to perform an evaluation of the safety improvement project over a 7.1-mile section of US 119 on the Whitesburg side of Pine Mountain in Letcher County to determine whether the types of improvements undertaken affected the overall safety of the roadway. Specific attention was given to the effects of a ban on truck traffic that was implemented in March 2001. In addition, there was a need to determine if the use of flexible design was successful after removal of the truck restriction by permitting trucks with dimensions up to the …

Analysis Of Traffic Crash Data In Kentucky (2002 - 2006), Eric R. Green, Kenneth R. Agent, Jerry G. Pigman

Kentucky Transportation Center Research Report

This report documents an analysis of traffic crash data in Kentucky for the years of 2002 through 2006. A primary objective of this study was to determine average crash statistics for Kentucky highways. Average and critical numbers and rates of crashes were calculated for various types of highways in rural and urban areas. These data can be used in Kentucky’s procedure to identify locations that have abnormal rates or numbers of crashes. The other primary objective of this study was to provide data that can be used in the preparation of the problem identification portion of Kentucky’s Annual Highway Safety …

Developing A Byproduct Materials Information Systems For The Kentucky Transportation Cabinet, David Q. Hunsucker, Justin Jones, Tom Hopkins, Charlie Sun

Kentucky Transportation Center Research Report

Kentucky has numerous coal-fired, electric generating facilities and, as a result, there are abundant byproduct materials being produced from these facilities that have environmental, engineering, and economic potential as materials for use in common highway construction and maintenance related activities throughout the Commonwealth. Other byproduct materials are being produced and are available that may have potential uses as well. Although large quantities of byproduct materials are produced in Kentucky and many of those materials have positive or neutral environmental impacts and excellent engineering properties, a formal regulatory framework for selecting, characterizing, recovering, and recycling these material types does not exist. …

Emergency Roadside Technician Dies When Struck By A Single-Unit Truck On An Interstate Shoulder, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

In the winter of 2005 a 52-year-old male emergency roadside technician (ERT), (providing traffic control support for police), died when he fell approximately 75 – 80 feet from a bridge after being struck by a single-unit truck. A policeman had responded to a call from a semi-truck driver on the interstate who had blown a tire while driving on an interstate. After the tire blew, the driver immediately pulled the semi onto the right shoulder and called police for assistance. This section of the shoulder was on a bridge on the blind side of a hill, and was too narrow …

Forage News [2007-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• UK All Commodity Field Day
• 8^th Kentucky Grazing Conference
• Hay Hotline Helps Farmers in Search of Forage
• Beware of Hay Payment Scam
• Judge Amends Roundup Ready Alfalfa Ruling
• Corn Acres Soar, Soy Acres Plunge
• Relative Feed Value (RFV) and Relative Forage Quality (RFQ)
• KFGC Awards
• Forage Spokesman Nominations
• Upcoming Events

2007 Safety Belt Usage Survey In Kentucky, Kenneth R. Agent, Eric R. Green

Kentucky Transportation Center Research Report

The objective of this study was to establish 2007 safety belt and child safety seat usage rates in Kentucky. The 2007 survey continues to document the results after enactment of the original “secondary enforcement” statewide mandatory safety belt law in 1994 and the change to “primary enforcement” which was enacted in 2006. Data were collected at 200 randomly selected sites spread across Kentucky. Data from the individual sites were combined into a statewide percentage considering roadway functional classification, geographic region, and vehicle miles traveled. The data show that the usage rate in 2007 (71.8 percent) increased several percentage points compared …

Evaluation Of Kentucky’S “Buckle Up Kentucky: It’S The Law & It’S Enforced” 2007 Campaign, Kenneth R. Agent, Eric R. Green, Ronald E. Langley

Kentucky Transportation Center Research Report

The objective of this report was to document the results of the “Buckle Up Kentucky: It’s the Law & It’s Enforced” 2007 campaign in Kentucky. Data were also taken to document the change in usage after enactment of the primary enforcement law. The campaign involved a combination of earned media, paid media, and enforcement. The earned media started about five weeks prior to Memorial Day 2007 and continued through the enforcement periods. The paid media campaign was for the two weeks prior to Memorial Day while the enforcement period was a two-week period including the week before and the week …

Optical Monitoring System With Molecular Filters, Robert A. Lodder, John Carberry

Pharmaceutical Sciences Faculty Patents

An optical monitoring system for determining the constituents of a sample or specimen. An absorption spectrum is obtained from a sample and is passed through one or more filters having a specified absorption spectrum defined by a single atom or a compound. If the filter's absorption spectrum is included in the sample's absorption spectrum, then the sample contains that atom or compound. The apparatus includes a switching assembly that sequentially places one or more filters into the light path to determine if the subject atom or compound is contained in the sample.

Revisiting He-Like X-Ray Emission-Line Plasma Diagnostics, R. L. Porter, Gary J. Ferland

Physics and Astronomy Faculty Publications

A complete model of helium-like line and continuum emission has been incorporated into the plasma simulation code Cloudy. All elements between He and Zn are treated, any number of levels can be considered, and radiative and collisional processes are included. This includes photoionization from all levels, line transfer, including continuum pumping and destruction by background opacities, scattering, and collisional processes. The model is calculated self-consistently along with the ionization and thermal structure of the surrounding nebula. The result is a complete line and continuum spectrum of the plasma. Here we focus on the ions of the He I sequence and …

Southeastern Law Librarian Summer 2007, Seaall

Newsletters

No abstract provided.

Context Sensitive Solutions For Construction And Maintenance, Theodore Hopwood Ii, Donald L. Hartman, Jerry G. Pigman

Kentucky Transportation Center Research Report

The objective of this research was to conduct a survey to assess the state of practice related to state highway agencies (SHAs) implementing context sensitive solutions including its application in Construction and Maintenance and to prepare a workshop enabling SHA officials to adopt practices promoting context sensitivity beyond Planning and Design.

Deliverables from the study efforts include a survey summary of context sensitive solutions and workshop materials/presentation suitable for use in training a wide range of SHA personnel working in Construction and Maintenance.

Neuropathological Findings Processed By Artificial Neural Networks (Anns) Can Perfectly Distinguish Alzheimer's Patients From Controls In The Nun Study, Enzo Grossi, Massimo P. Buscema, David Snowdon, Piero Antuono

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Many reports have described that there are fewer differences in AD brain neuropathologic lesions between AD patients and control subjects aged 80 years and older, as compared with the considerable differences between younger persons with AD and controls. In fact some investigators have suggested that since neurofibrillary tangles (NFT) can be identified in the brains of non-demented elderly subjects they should be considered as a consequence of the aging process. At present, there are no universally accepted neuropathological criteria which can mathematically differentiate AD from healthy brain in the oldest old. The aim of this study is to discover …

Delivery System For A Composition, Bruce J. Hinds Iii, Audra L. Stinchcomb

Chemical and Materials Engineering Faculty Patents

Devices and methods for cutaneous delivery of a composition are provided, wherein the composition is passed through an ordered nanoporous membrane in fluid communication with a reservoir. The nanoporous membrane includes a plurality of aligned hollow nanotubules coated with a continuous polymer matrix, and etched to open the plurality of hollow nanotubules and form pores. In one embodiment, the etching step oxidizes an end of the nanotubules to form carboxylate groups. The ordered nanoporous membrane further includes at least one additional functional unit bound to the carboxylate groups. The at least one additional functional unit selectively exposes or at least …

Mentoring Youth In 4-H, Ken Jones

Community and Leadership Development

No abstract provided.

Azithromycin In The Extremely Low Birth Weight Infant For The Prevention Of Bronchopulmonary Dysplasia: A Pilot Study, Hubert O. Ballard, Michael I. Anstead, Lori A. Shook

Pediatrics Faculty Publications

BACKGROUND: Azithromycin reduces the severity of illness in patients with inflammatory lung disease such as cystic fibrosis and diffuse panbronchiolitis. Bronchopulmonary dysplasia (BPD) is a pulmonary disorder which causes significant morbidity and mortality in premature infants. BPD is pathologically characterized by inflammation, fibrosis and impaired alveolar development. The purpose of this study was to obtain pilot data on the effectiveness and safety of prophylactic azithromycin in reducing the incidence and severity of BPD in an extremely low birth weight (< or = 1000 grams) population.

METHODS: Infants < or = 1000 g birth weight admitted to the University of Kentucky Neonatal Intensive Care Unit (level III, regional referral center) from 9/1/02-6/30/03 were eligible for this pilot study. The pilot study was double-blinded, randomized, and placebo-controlled. Infants were randomized to treatment or placebo within 12 hours of beginning mechanical ventilation (IMV) and within 72 hours of birth. The treatment group received azithromycin 10 mg/kg/day for 7 days followed by 5 mg/kg/day for the duration of the study. Azithromycin or placebo was continued until the infant no longer required IMV or supplemental oxygen, to a maximum of 6 weeks. Primary endpoints were incidence of BPD as defined by oxygen requirement at 36 weeks gestation, post-natal steroid use, days of IMV, and mortality. Data was analyzed by intention to treat using Chi-square and ANOVA.

RESULTS: A total of 43 extremely premature infants were enrolled in this pilot study. Mean gestational age and …

Adherence To Recommendations For Follow-Up To Abnormal Pap Tests, Katherine S. Eggleston, Ann L. Coker, Kathryn J. Luchok, Tamra E. Meyer

CRVAW Faculty Journal Articles

OBJECTIVE: To evaluate whether timely adherence rates differ by race among women with abnormal Pap tests participating in a cost-free or reduced-cost program.

METHODS: Eligible subjects included women aged 47-64 years who received a referral for follow-up care after an abnormal Pap test from 1999 to 2002 in South Carolina (n=330). Adherence was measured as days to receipt of follow-up care after an abnormal Pap test. Cox proportional hazards modeling was used to estimate risk factors associated with time to adherence within 60 and 365 days by race.

RESULTS: African-American and non-Hispanic white women had similar adherence to follow-up. Among …

Use Of Reflective Armbands To Improve Adolescent Pedestrian And Pedalcyclist Safety, Nancy Dunaway, Eric R. Green, Jerry G. Pigman, Monica L. Barrett

Kentucky Transportation Center Research Report

The objective of this effort was to determine if elementary and middle school students could be educated to use reflective armbands to increase their visibility to motorists while walking or bicycling to school. The number of armbands and surveys distributed totaled slightly over 7,000. Responses were received from approximately 12 percent (873) of the pre-surveys and slightly over 3 percent (119) of the post-surveys. Respondents to the survey indicated nearly 15 percent of schoolchildren receiving reflective armbands were wearing the armband “every day” or “most days”. Of the parents responding, 21 percent indicated their children would continue to wear the …

Stockpiling Hydrated Lime-Soil Mixtures, Tommy C. Hopkins, Tony L. Beckham, Charlie Sun

Kentucky Transportation Center Research Report

The concept and feasibility of stockpiling and reusing hydrated lime-soil mixtures to stabilize particular areas on stabilization projects after the mixing contractor has departed were examined. In chemical stabilization of subgrades, situations often arise where additional areas need to be stabilized after the specialty contractor and mixing equipment have left the project. Field and laboratory investigations were performed to determine if a soil mixed with hydrated lime during routine lime subgrade stabilization could be mixed, stockpiled, and used later. In laboratory studies, hydrated lime-soil mixtures were stockpiled loosely in the laboratory. CBR specimens of the stockpile material were remolded and …

Improve Safety Of Workers During Highway Construction And Maintenance, Donn E. Hancher, Kenneth Bussey, Robin Meagher, Jonathan Ross, Kristin Smith

Kentucky Transportation Center Research Report

There is an inherent risk of injury or fatality in all occupations. Even secretarial occupations face jobsite hazards such as carpal tunnel and back injury. The nature of the construction industry combined with the required physical demand and rigorous work processes, make it an industry with higher risk of injury or fatality. In an effort to decrease that inbuilt jobsite risk that construction workers face, this study will analyze the current best safety practices, examine new safety technologies, and collaborate with construction workers themselves to gain a better perspective of what jobsite hazards they face.

Specifically, this study will focus …

Recycling Practices For Environmental Materials, Sudhir Palle, Steve Higgins, Theodore Hopwood Ii

Kentucky Transportation Center Research Report

Two environmental materials, tree and brush debris and large animal roadkill carcasses were investigated. The disposal methods for these materials were reviewed as opportunities/methods for possible recycling. KYTC established several pilot composting operations in 2006. These were monitored during their preliminary stages of operation.

Prevention Of Voc Releases From Bridge Painting Operations, Theodore Hopwood Ii, Rick Younce, Sudhir Palle

Kentucky Transportation Center Research Report

Bridge maintenance painting employs solvent-based coatings that generate volatile organic compounds (VOCs) that contribute to air-quality problems. Methods for capturing VOCs during normal Kentucky Transportation Cabinet (KYTC) maintenance painting operations were investigated. One method, activated carbon adsorption, is adaptable to KYTC operations. Related factors including area of bridge, coating systems, containment volumes and VOC out gassing rates were reviewed. A commercial source of activated carbon adsorption equipment was identified and issues related to employing that technology for bridge painting were identified.

Compaction Of Mixtures Of Hard Rocks And Soft Shales And Non-Durable Shales Using Impact Compactors, Tommy C. Hopkins

Kentucky Transportation Center Research Report

Impact roller compaction has been used to improve embankment and highway subgrades in South Africa, Australia, Europe, and China and other areas of the world. In September of 2003, the International Technology Scanning Program, sponsored by the Federal Highway Administration (FHWA), the American Association of State Highway and Transportation Officials (AASHTO), and the National Cooperative Highway Research Program of the Transportation Research Board, identified this technology as one of several foreign technologies and innovations that could significantly benefit U.S. transportation systems. The technology was high-lighted at the Fifth International Conference on the Bearing Capacity of Roads and Airfields in 1998 …