Digital Commons Network^™

Dexamethasone Serum Concentrations After Intravenous Administration In Horses During Race Training, S. Mcclure, C. K. Fenger, Bradley Brown, George Maylin, W. Duer, L. Dirikolu, Kimberly Brewer, Jacob Machin, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Dexamethasone (DXM) sodium phosphate is a widely used corticosteroid for inflammatory conditions in horses, regulated in racing jurisdictions in the USA by a 0.005 ng/ml serum/plasma threshold. This study seeks to describe serum concentrations of DXM at 48 and 72 h after intravenous administration of 20 mg DXM sodium phosphate over 1 to 5 days, and to identify a possible source of DXM overages. 74 horses (39 Thoroughbreds, 13 Standardbreds, 22 Quarter Horses) in active race training received 20 mg DXM sodium phosphate. Serum was collected before injection, at 48 and 72 h post last injection, and analysed by LC/MS-MS …

A Fat Imposter: The Embodied Intersection Between Race, Body Type And Fatness In Margaret Cho’S Comedy, Julia Cox

Theses and Dissertations--Linguistics

Margaret Cho is a comedic goddess who, in her mockery, serves flaming hot social commentary about race, body image, and fatness. Within this thesis, I used critical discourse analysis to understand how Margaret Cho embodies Asianness, whiteness, and the body types and images prescribed respectively. While working on data analysis, I came across a common media trope of fat women: the use of indexically Southern (United States), Appalachian, and Working class indexicals in speech and lexical items. I connected the ideologies surrounding Southern and Appalachian language to the inequalities that fat women face. This voicing had not previously been written …

2020 Kentucky River Watershed Watch: Annual Report, Malissa Mcalister, Steven Evans

Kentucky River Watershed Watch

No abstract provided.

Maybe Coal Shouldn’T Keep The Lights On: An Analysis Of Climate Change In Kentucky And Potential Legislation That Could Mitigate Its Effects, Shelby Lamar

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Unprotected And Overworked: An Analysis Of The Abuses Migrant Horse Workers Face Under The H-2b Program, Jocelyn Lucero

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Precision Nutrition And Advanced Culinary Medicine, Sara B. Police

Pharmacology and Nutritional Sciences Textbook Gallery

This electronic textbook (eBook) accompanies NS801, Precision Nutrition and Advanced Culinary Medicine, a 1-credit, 8-week online medical elective course for the University of Kentucky College of Medicine Office of Medical Education. The eBook provides module-based background information including text, tables, and figures to support each module of the online course:

1. Introduction
2. Culinary Challenges Preparation
3. Emerging Concepts in Precision Nutrition
4. Cardiovascular Disease & Nutritional Considerations
5. Neurological and Mental Health Disorders & Nutritional Considerations
6. Cancer & Nutritional Considerations
7. Gastrointestinal (GI) Health, Microbiome & Nutritional Considerations
8. Renal Conditions & Nutritional Considerations

As an open access textbook supported by the University of Kentucky Libraries …

The Pearl Of Siberia: The Emerging Threat To Lake Baikal, Blake Donithan

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Old World Regulations And New World Flexibility: Countering The Effects Of Climate Change On Wine, Seth Stroud

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Uncommon Issues With Industrial Hemp Production Contracts, Rusty W. Rumley, Scout Snowden

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Placing Bets On Adw Legality: An Inquiry Into Off-Track Horse Gambling, Thomas Staffieri

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Understanding Struggles And Triumphs Of Widows In Central Nigeria: A Path To Communication And Economic Empowerment, Meredith Annette Garrison

Theses and Dissertations--Communication

One in ten African women age 15 or older are widows. Approximately 8 million widows live in Nigeria with many living in extreme poverty. Throughout the nation, widows are subjected to physical and psychological harm from their families and communities following the deaths of their husbands. Women are marginalized across Nigeria, but widowed women often experience ostracization and oppression that leads to poverty. Most widows rely on informal business and petty trading to survive but these ventures typically only bring in less than a $1 a day for a family. This dissertation critically examined the situation of widows in a …

The Consent Of Man: An Examination Of Privacy Awareness, Surveillance, And Privacy Policy (Mis)Use, Will Reilley Silberman

Theses and Dissertations--Communication

The problem of privacy is nuanced, pervasive, and requires an elevated approach. Given the lack of consistency with regard to privacy’s conceptualization and operationalization, research is needed that examines variables related to privacy to better understand how privacy operates in the present day. This dissertation aims to better understand nuances of privacy by gauging knowledge of online privacy, technological affordances related to privacy, and knowledge of surveillance. In this study, human subjects from a large southern University were presented with an opportunity to use a privacy-invasive smartphone application. After doing so, they viewed one of three privacy policies. Finally, they …

Zilpaterol And Ractopamine: Reaching Consensus On Trace-Level Transfers To Racehorses, Jacob Machin, Kimberly Brewer, Clara K. Fenger, Sarah White-Springer, Abelardo Morales-Briceno, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

In this article, we review the investigation of trace amounts of b-2 adrenergic agonists, a drug class that possess significant risk to the integrity of horse racing whether intentionally used or through the inadvertent contamination of feed.

Arabinoxylan Structural Profiling Of Cool-Season Pasture Grasses Via High-Performance Anion-Exchange Chromatography With Pulsed Amperometric Detection (Hpaec-Pad) Analysis Of Endoxylanase Digests, Glenna Erin Joyce

Theses and Dissertations--Animal and Food Sciences

Arabinoxylan (AX) is a major structural polysaccharide found in the cell walls of monocots such as cereal grains and pasture grasses. The variety of AX structural components and substitution patterns contribute to AX structural diversity between different monocot species as well as plant tissues.

The rumen is the first digestion site of masticated food material in cattle and provides 70% of energy to host through fermentation of forage. There are many species of pasture grasses that act as a forage source. Differences in AX structure found in these pasture grasses may impact rumen microbial fermentation. Understanding the AX structure of …

Predicting Tomorrow: Optimizing The Early Detection Of Disease And Disease Recovery In Dairy Calves Using Precision Technologies, Melissa Cantor

Theses and Dissertations--Animal and Food Sciences

The leading causes of morbidity and mortality in preweaned dairy calves are diarrhea and bovine respiratory disease complex (BRD). The delayed detection of these diseases in calves can also delay intervention and disease recovery. The overarching objective of this dissertation was to follow a cohort of calves daily for the first 90 days of life for naturally occurring clinical BRD bouts and diarrheal bouts. The objective answered if feeding behaviors and activity levels were different in at-risk calves during BRD development and BRD recovery from an antimicrobial intervention. Furthermore, the potential of colostrum replacer as a feeding intervention strategy to …

Influence Of Dietary Manipulation On The Relationship Between Temperament Measures And Growth In Beef Cattle: Endophyte Exposure, Phytogenic Supplementation, And Controlled Feeding, Paul Shanks

Theses and Dissertations--Animal and Food Sciences

The influence of dietary factors (including endophyte exposure, phytogenic supplementation, and controlled feeding) on relationships between exit velocity (EV), growth performance in grazing and finishing cattle, and carcass characteristics were explored. Two grazing studies were conducted evaluating EV effects on cattle grazing both toxic and nontoxic endophyte-infected tall fescue. Cattle were followed through two subsequent finishing studies and an additional beef cattle finishing beef cattle study was also conducted. Results from these studies agree with many literature reports indicating that EV measures relate to growth performance and associated carcass traits in beef cattle being fed high energy diets in confinement, …

Impact Of Mineral Supplementation On Intake Behavior And Blood Flow In Growing Beef Cattle Exposed To Fescue-Derived Alkaloids, Hannah Marie Herzing

Theses and Dissertations--Animal and Food Sciences

Consumption of endophyte-infected tall fescue by cattle has repeatedly been shown to negatively impact dry matter intake (DMI), growth rate, and circulating prolactin concentrations. The objective of the current study was to determine if a mineral supplementation would mitigate the negative effects of fescue-derived alkaloid consumption on feed intake, circulating prolactin, and the vascular system. Twelve Angus crossbred steers were used in a triplicated Latin square design consisting of three 28 d experimental periods. Treatments consisted of three top-dressed mineral supplements (142 g/head/d): a non-medicated control (CON), commercially available Fescue EMT® Mineral Defense (EMT), and a test prototype (EMT 2). …

The Effects Of Form Of Selenium On The Bovine Corpus Luteum, Uterine Endometrium, And Development Of The Conceptus, Benjamin Ryne Crites

Theses and Dissertations--Animal and Food Sciences

Widespread regions of the southeast United States have soils deficient in selenium (Se), necessitating Se supplementation to cattle grazing in these areas. Adequate dietary Se is required for optimal immune function, growth, and fertility. In forages, Se is predominantly found in the organic form (OSe), which is known to increase bioavailability. However, the inorganic form (ISe) is typically found in commercial mineral mixes. We previously reported that supplementation with an isomolar 1:1 mix (MIX) of ISe (sodium selenite, Prince Se Concentrate; Prince Agri Products, Inc., Quincy, IL) and OSe (SEL-PLEX, Alltech Inc., Nicholasville, KY) increases early luteal phase concentrations of …

Monocyte Abundance And White Blood Cell Expression Of Prolactin And Nf-Kb Pathway Genes In Beef Steers Are Altered By Grazing Toxic Endophyte-Infected Tall Fescue And Lipopolysaccharide Challenge, Cecilia Winfrey

Theses and Dissertations--Animal and Food Sciences

Experiment 1 tested the hypothesis that ad libitum consumption of a 1:1 blend (MIX) of sodium selenite (ISe) and SELPLEX vs solely ISe as selenium (Se) supplements (27 ppm) in a vitamin-mineral mix (V-M) by steers subjected to summer-long grazing of toxic endophyte-infected tall fescue (TE) would ameliorate the negative effects of TE by positively affecting the expression pattern of prolactin (PRL) and NF-kB pathway genes by circulating leukocytes (WBC). Experiment 2 tested the hypothesis that the MIX form of supplemental Se also would ameliorate the negative effects of in vitro blood lipopolysaccharide challenge (LPS) on WBC gene expression. The …

Impact Of Feeding Foods Containing Industrial Hemp-Derived Cannabidiol On Canine Health And Well-Being, Elizabeth M. Morris

Theses and Dissertations--Animal and Food Sciences

Anecdotal evidence of beneficial behavioral and health effects of cannabidiol (CBD) use in companion animals has amplified the need to elucidate safety and potential impacts of CBD use. The purpose of this investigation was to determine the impact of industrial hemp-derived CBD administration on canine health and well-being. We hypothesized that CBD would produce beneficial effects on canine behavior without negatively impacting animal health. Dog treats were formulated to include CBD and shown to be palatable across a range of CBD inclusion levels. Dogs were supplemented with CBD treats and subjected to a noise-induced fear response test to assess potential …

Electrifying: Facilitating The Transition To Electric Lawn And Garden Equipment, Bryan Hull, Ryan Murphy

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

A Novel Role For Neurotensin In Regulation Of Stem Cell Function In The Small Intestine, Stephanie Rock

Theses and Dissertations--Toxicology and Cancer Biology

Neurotensin (NT) is a nutrient-regulated gut hormone that plays important roles in lipid absorption, obesity, metabolic disorders, and normal and neoplastic growth in the intestine. In this study, we 1) elucidate the mechanisms regulating NT release from endocrine cells, 2) examine the role of NT on proliferation and stem cell function in the small intestine and 3) define the effects of NT on colorectal cancer stem cells. We report that NT release from endocrine cells is enhanced by the MAPK scaffold protein Kinase Suppressor of Ras 1 (KSR1) and the exocyst complex component 70 (Exo70). Moreover, free fatty acid stimulated …

Residual Spatial Autocorrelation In Macroecological And Biogeographical Modeling: A Review, Guetchine Gaspard

Theses and Dissertations--Geography

Macroecological and biogeographical modelers have predicted the distribution of species across space relying on the relationship between biotic processes and environmental variables. Such a method employs data associated, for instance, with species abundance or presence/absence, climate, geomorphology, and soils. Statistical analyses found in previous studies have highlighted the importance of accounting for the effects of spatial autocorrelation (SAC), which indicates a level of dependence between pairs of nearby observations. A consensus has existed that residual spatial autocorrelation (rSAC) can substantially impact modeling processes and inferences. However, more emphasis should be put on identifying the sources of rSAC and the degree …

Micromending The Metabolic Rift: An Analysis Of Food Waste Composting Systems In Lexington, Kentucky, Casey Byrd

Theses and Dissertations--Geography

The metabolic rift theory explores materials and social exchanges between rural and city communities and human-nature relations. Metabolic rifts can exist both environmentally and socially and are often geographically or culturally unique. Ultimately the metabolic rift is earmarked by increasing disconnection between humans and their environment. This thesis draws upon life cycle analysis studies, social-economic studies, and environmental and sustainability studies to argue that large-scale contemporary urban composting efforts, although well intended, are insufficient to mitigate the effects of the metabolic rift. Mobilizing theories around capitalism and the metabolic rift, this research paper connects social, environmental, and economic notions of …

Bio-Spatial Policing In Theory And Practice: Examining Impacts And Resistance Through Mobilities And Children's Everyday Life, Emily Kaufman

Theses and Dissertations--Geography

Despite decades of reforms and technological innovations, increasing evidence shows that state securitization disproportionately harms already racially, spatially, and socio-economically marginalized communities. My research investigates uneven impacts of state securitization, from punitive welfare programs to school surveillance to policing. Across sites, I focus on scales, voices and the everyday lived experiences often left out of scholarly discourse and sensational media. In the current climate of growing awareness and scholarship on police violence, my dissertation addresses three less-studied areas: 1) the interplay between racial, gendered, spatial, and technified police practices; 2) how these practices impact the everyday lives of those racially …

Effects Of Season And Nutrition On Insulinemic Responses In Insulin Dysregulated Horses, Erica Lyn Macon

Theses and Dissertations--Veterinary Science

Insulin dysregulation (ID) is the main risk factor for the development of hyperinsulinemia-associated laminitis (HAL). ID in the equid has been extensively researched; however, recommendations for diagnosing and managing ID horses have originated from work completed in other models, such as the ID pony and healthy horse. Therefore, our overall objective was to improve current diagnostic tools and nutritional management strategies by investigating the effect of season, the fed and fasted state on the oral sugar test (OST) and dietary nutrient content on insulinemic responses in the ID horse. To address this, four main objectives with three specific aims were …

Farmer Suicide: Rates, Trends, And Associations To Commodity Production Among States Reporting Violent Deaths, 2003-2017, Paul Norrod

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Occupational studies show that farmers are at higher risk for suicide with rates at least two-fold those of the U.S. population.2-4 Therefore, the purpose of this study was to (1) determine age- and sex-specific farmer suicide rates, (2) evaluate rate trends, and (3) assess the relationship between commodity production and farmer suicide using the National Violent Death Reporting System (NVDRS) and quinquennial Census of Agriculture. We identified 1,652 farmer suicide cases from the NVDRS. Age-specific rates showed the highest rates among male farmers over 64 at 14.03 per 100,000. Annual rates for the 15-year study period peaked during 2013 at …

Evaluation Of The Effectiveness Of A Pain Neuroscience Education Curriculum For Patients Who Experience Chronic Musculoskeletal Pain With Concurrent Opioid Dependence, Nicole D. Windsor

Theses and Dissertations--Rehabilitation Sciences

Background: Chronic musculoskeletal pain (CMP) is estimated to affect over 100 million adults annually and is targeted as an instigator of opioid dependence (OpD). Opioid medications are often the first response for patients suffering from CMP, but over 10 million people annually admit to misusing opioids. With the opioid epidemic, the healthcare system now has a population of patients who experience CMP with concurrent OpD. This persistent problem creates a perfect storm of fear of movement, low self-efficacy, and physical dysfunction. A critical component to chronic pain management is understanding how patients view their pain experience. Education may be one …

The Use Of Mechanotherapy To Promote The Recovery From Disuse Atrophy In Aging Rat Skeletal Muscle, Zachary Hettinger

Theses and Dissertations--Rehabilitation Sciences

The combination of age and disuse-related skeletal muscle atrophy predisposes older adults to reduced mobility, loss of independence, and poor quality of life. Poor health outcomes resulting from periods of disuse in older adults are exacerbated by an inability to fully recover, ultimately accelerating geriatric populations towards further functional decline. Aged-related changes to skeletal muscle viscoelastic properties, specifically of muscle extracellular matrix (ECM) stiffness, may not only impact how muscle responds during recovery, but also to interventions intended to augment recovery. Remodeling of muscle ECM in the aged may therefore benefit muscle mass recovery, yet therapies focused on ECM remodeling …

Introduction To Special Issue Of Plant Virus Emergence, Michael M. Goodin, Jeanmarie Verchot

Plant Pathology Faculty Publications

No abstract provided.