Digital Commons Network^™

Effects Of Environmental And Political Framework On Alpine Farming And Its Development In The Entlebuch Unesco Biosphere Reserve Switzerland, Pius Hofstetter, A. Boltshauser, E. Ruoss

IGC Proceedings (1977-2023)

No abstract provided.

Bodyweight Gain Of Grazing Sheep Responses To Stocking Rate In Stipa Breviflora Steppe, Zhongwu Wang, Guodong Han, Mengli Zhao

IGC Proceedings (1977-2023)

No abstract provided.

Supplementation Levels For Crossbred Steers Kept In Pastures Grazing Brachiaria Brizantha, I. F. Andrade, M. M. Leão, A. A. F. Baião, E. A. A. M. Baião

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of The Pasture On Milk Production From Cinisara Cows Over The Seasons, M. Alabiso, C. Giosuè, M. L. Alicata, V. Ilardi, D. Giambalvo, G. Maniaci

IGC Proceedings (1977-2023)

No abstract provided.

An Investigation On Diet Selection By Sheep And Goats In Steppe Regions Of Yazd Province, Iran, Anahita Rashtian, Mansour Mesdaghi, Masoume Amirkhani

IGC Proceedings (1977-2023)

No abstract provided.

"Playing The Game": A Case Study Of Latinx Leaders In An Agricultural Youth Organization, Graciela Barajas

Theses and Dissertations--Community & Leadership Development

Latinx members of the FFA Organization are disproportionately underrepresented in leadership positions. When they do get elected to leadership offices, they oftentimes have to accept behaviors that erase their cultural identity. This study aims to find what aspects of their identity they feel they have to give up in order to be seen as a potential state or national FFA candidate. Findings include the participation of the state-officer game, joining cliques that fit the white mold, and overall, assimilation on an individual and group scale. Recommendations include systemic change for state and national FFA staff, agricultural education, and the agricultural …

Care Working Conditions: The Ethics And Politics Of Social Reproductive Labor From Aristotle To Marxist Feminism, Andrew R. Van't Land

Theses and Dissertations--Philosophy

The spectre of an inescapably divided working class has haunted every generation of marxist theorists, including the latest wave of marxist feminists engaged in the research programme known as Social Reproduction Theory (SRT). In this dissertation, I will explain how Marx’s clear theoretical debt to Aristotle extends into the marxist feminist analysis of social reproductive labor and of the exploitation, class interests, and normative demands which condition such care workers. I will demonstrate how SRT can follow Marx’s own example in reading Aristotle, critically yet charitably, in order to resolve three problems. First, Aristotle’s original concept of use value (built …

Epigenetic States Regulate Tumor Aggressiveness And Response To Targeted Therapies In Lung Adenocarcinoma, Fan Chen

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, 85% of which are lung adenocarcinomas (LUAD). Although molecular studies of NSCLC identified targetable mutations of some oncogenes including BRAF, EGFR and ALK, no targeted therapies exist for most cases. Cancer epigenetics is the study of epigenetic modifications, including histone modifications, that control gene expression in cancer. Recent advances have revealed numerous epigenetic abnormalities in human cancers, and targeting epigenetic regulators could be effective at reversing dysregulated epigenetic programs or driving sensitivity to other targeted therapies.

Inhibitors of the histone methyltransferase EZH2 have recently been approved as …

The Tumor Suppressor Par-4 Regulates Hypertrophic Obesity, Nathalia Araujo

Theses and Dissertations--Toxicology and Cancer Biology

Prostate Apoptosis Response-4 (Par-4) is a tumor suppressor ubiquitously expressed in all tissues and able to selectively induce apoptosis in cancer cells. Although well established in the context of cancer, relatively little is known about the function of Par-4 in the healthy and non-tumorigenic context. Observations from our lab showed that Par-4 knockout mouse lines were obese and displayed adipocyte hypertrophy under a normal chow diet when compared to Par-4 wild-type mice. These Par-4 knockout mice exhibited hepatic steatosis and hyperinsulinemia as secondary consequences of obesity. Par-4 knockout mice displayed increased intestinal dietary fat absorption and its subsequent storage in …

Mechanisms Of Cadmium-Induced And Epidermal Growth Factor Receptor Mutation-Driven Lung Tumorigenesis, Hsuan-Pei Lin

Theses and Dissertations--Toxicology and Cancer Biology

Cadmium (Cd) is a ubiquitous pollutant in the environment and a known carcinogen for lung cancer. Cd has been shown to act as a weak mutagen, which suggests that it may exert tumorigenic effect through non-genotoxic ways, such as epigenetic mechanisms. The goal of this project is to investigate the mechanisms of Cd carcinogenesis focusing on the role of lncRNA dysregulations. The Cd-exposed cells formed significantly more colonies in soft agar, displayed cancer stem cell (CSC)-like property and formed tumors in nude mice. Mechanistically, the lncRNA microarray analysis revealed that chronic Cd exposure dysregulates lncRNA expressions. Q-PCR analysis confirmed the …

Delineating The Role Of Fatty Acid Metabolism To Improve Therapeutic Strategies For Colorectal Cancer, James Drury

Theses and Dissertations--Toxicology and Cancer Biology

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the world, comprising over 1 million new cases each year and over 500,000 deaths. CRC, when detected at an early stage of disease development, can be effectively treated, with a 5-year survival rate of over 90%. Such standard treatments include surgical resection of the primary tumor in combination with adjuvant chemotherapy. However, even with advancements in surgical procedures and chemotherapeutic targets, when CRC progresses to a more advance stage, the 5-year survival rate decreases significantly to just under 14%. This stark decrease in patient survival rate can be directly …

Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin

Theses and Dissertations--Toxicology and Cancer Biology

Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …

Forage News [2021-01], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Visualizing Barrier Dysfunction Using Clarity, Rachel Robbe

Lewis Honors College Thesis Collection

Epilepsy and Alzheimer’s disease are two prevalent neurological disorders. The blood-brain barrier (BBB) is a factor in why there are no long-term treatments for these diseases. The transporters in the neurovascular unit (NVU), which makes up the BBB, are highly specialized, so most drugs cannot pass the barrier to treat these diseases. It is unknown why drug uptake in the BBB varies in a diseased and wild-type brain, but one theory is that there are spatial differences in the NVU. One method for examining the NVU is the CLARITY tissue clearing technique which is unique in its capability to clear …

Effects Of Sleep Fragmentation On The Progression Of Alzheimer’S Disease, Lindsay Beechem

Lewis Honors College Capstone Collection

Alzheimer’s Disease (AD) is a neurodegenerative disease that is characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuronal death, and profound cognitive impairment. Previous studies have indicated that increased Aβ and alterations in the daily sleep-wake cycle are early risk factors and possible predictors of AD. Acute sleep deprivation decreases Aβ clearance, and increased Aβ levels stimulate neuroinflammation and accelerate loss of neurons and synapses. Likewise, it has been shown that there are higher rates of sleep disorders in AD patients. However, limited studies have investigated whether sleep fragmentation accelerates the progression of AD pathology. This partial review will discuss experiments …

An Exploration Of Sleep Fragmentation And Sleep Enhancement In Mice, Frannie Salisbury

Lewis Honors College Capstone Collection

Alzheimer’s Disease (AD) is a neurodegenerative disease that is can be defined by amyloid beta (Aβ) plaques, neurofibrillary tangles, and neuronal death. AD patients have characteristically fragmented sleep, with frequent nighttime awakenings and daytime naps. Decreased clearance of Aβ from disrupted sleep may be a contributing factor in the progression of AD. This study investigated how sleep fragmentation effected the progression of AD in 3xTgAD mice. Results showed that sleep fragmented mice had significantly more Aβ build-up in the hippocampus and thus greater progression of AD when compared to control mice. Improving sleep may be one way to reduce the …

Animating Plastics: Shinto And Environmentalism In Sayaka Ganz’S Reclaimed Creations, Erin Inouye

Oswald Research and Creativity Competition

Sculpture artist Sayaka Ganz uses found plastic objects to create intricate recreations of nature. From the pair of horses in Emergence II to the monumental whale Nanami, Ganz’s work breathes new life into discarded plastic materials that would otherwise lay dormant in landfills and trash cans. Ganz herself attributes her attraction to working with alternative sculptural materials to the emphasis on Shinto animist beliefs engrained in her throughout her upbringing.

This presentation will explore the ways in which Sayaka Ganz’s Reclaimed Creations series demonstrate Aike P. Rots’s theory of the Shinto Environmentalist Paradigm which asserts that the “animistic” beliefs …

Negative Regulatory Factors In Tombusvirus Replication: Known Proteins, Novel Roles, Paulina Alatriste González

Theses and Dissertations--Plant Pathology

Although host cells are a rather rich source for co-opted host factors, lipids and metabolites, positive stranded RNA viruses vastly rewire cellular pathways and remodel cellular membranes to support viral replication. To accomplish such major changes, these viruses depend on the availability of different host factors and the ability to readily assemble viral replication organelles (VROs). Genome-wide screens and proteomics approaches with Tomato Bushy Stunt Virus (TBSV) in a yeast model host indicated that tombusviruses rely on the cellular cytoskeleton to reorganize the cellular environment of their hosts. Using temperature-sensitive (ts) mutants of beta and gamma-tubulin proteins and pharmacological inhibitors, …

Physicochemical And Functional Property Modification Of Myofibrillar Protein By Phenolic Compounds Under Oxidative Stress, Anqi Guo

Theses and Dissertations--Animal and Food Sciences

Polyphenol-rich spices and extracts of phenolic compounds are widely utilized in meat processing to modify product flavors. Chemically, polyphenols are reactive with myofibrillar protein (MP), the most functional fraction of all muscle proteins responsible for texture development in comminuted meat products. Such protein–polyphenol interaction is prevalent under oxidative conditions that are common in meat processing. As a large group of phytochemicals with diverse structures, phenolic compounds are known to interact with MP with varying efficacies. Yet, the structure-function relationship of polyphenols in eliciting modification of MP is poorly understood. The overall objective of this dissertation research was to elucidate the …

The Effect Of Oil Type, Oil Quality, Vitamin E, And Phytase Supplementation On Broiler Performance, Apparent Nutrient And Energy Utilization, And The Fatty Acid Profile Of Fat And Liver In Broiler Chickens, Richard A. Adefioye

Theses and Dissertations--Animal and Food Sciences

Two experiments were conducted to examine the effects of oil type, oil quality, phytase, and vitamin E (VE) supplementation in broiler chickens. Experiment 1 used 378-day-old male by-product Cobb breeder chicks with 9 treatments, 7 replicates, and 6 birds per replicate, structured as a 2x2x2+1 factorial arrangement of treatments for 14 days. The first 8 treatments were based on a marginally non-phytate phosphorus (NPP) deficient diet (0.31%), while treatment 9 was a positive control (PC) diet with adequate NPP levels (0.45%). There were 2 levels of phytase (0 vs 1000 FTU/kg), 2 levels of oil quality (fresh soy oil; peroxide …

Animal And Plant Protein Oxidation: Chemical And Functional Property Significance, Youling L. Xiong, Anqi Guo

Animal and Food Sciences Faculty Publications

Protein oxidation, a phenomenon that was not well recognized previously but now better understood, is a complex chemical process occurring ubiquitously in food systems and can be induced by processing treatments as well. While early research concentrated on muscle protein oxidation, later investigations included plant, milk, and egg proteins. The process of protein oxidation involves both radicals and nonradicals, and amino acid side chain groups are usually the site of initial oxidant attack which generates protein carbonyls, disulfide, dityrosine, and protein radicals. The ensuing alteration of protein conformational structures and formation of protein polymers and aggregates can result in significant …

Adjudicating On-The-Track Outcomes In Kentucky: Why Horse Administrators Should Provide Competitors A Right To Review, Howard Ball

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Horses, Humans, And The Law: A Study Of Four Pillars Of Support For Horse Ownership, Elaine M. Ramesh

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Sediment Transport Investigation In A Karst Basin Defines Governing Transport Processes And Explains Hysteresis Patterns, Leonie Bettel

Theses and Dissertations--Civil Engineering

Water resources researchers have advanced our understanding of sediment transport in karst aquifers and cave systems in recent years. However, we find knowledge gaps for sediment transport in karst including knowledge of processes controlling sediment hysteresis patterns from sensor datasets, and knowledge of dominant sediment transport processes that lead to sediment transport formulas for prediction. To address these gaps, we analyze a new suspended sediment, electrical conductivity and water flowrate datasets from sinking streams and a phreatic cave system for an epigenetic karst basin in the inner bluegrass region of Kentucky USA.

Three sediment patterns are common including: pulses of …

Modeling And Prioritizing Interventions Using Pollution Hotspots For Reducing Nutrients, Atrazine And E. Coli Concentrations In A Watershed, Olufemi Abimbola, Aaron Mittelstet, Tiffany L. Messer, Elaine Berry, Ann Van Griensven

Biosystems and Agricultural Engineering Faculty Publications

Excess nutrients and herbicides remain two major causes of waterbody impairment globally. In an attempt to better understand pollutant sources in the Big Sandy Creek Watershed (BSCW) and the prospects for successful remediation, a program was initiated to assist agricultural producers with the implementation of best management practices (BMPs). The objectives were to (1) simulate BMPs within hotspots to determine reductions in pollutant loads and (2) to determine if water-quality standards are met at the watershed outlet. Regression-based load estimator (LOADEST) was used for determining sediment, nutrient and atrazine loads, while artificial neural networks (ANN) were used for determining E. …

The Global Issue Of Immigration: A Focus On Illegal Immigrants For U.S. Agriculture, Refugee Immigrants For Germany’S Trade And The Climate-Induced Diaspora From Least Developed Countries, Yunzhe Zhu

Theses and Dissertations--Agricultural Economics

Nowadays, the large scale of migratory movements caused by violence, poverty or climate change have made topics related to this worldwide diaspora a vanguard of research on international development. For one thing, the so-called “caravan migrants” that traveled from Central America in search for a better life in the U.S. have been blocked at the U.S.-Mexico border while U.S. agricultural sectors that are labor-intensive, such as the sectors of fruits and vegetables where most illegal immigrant farmworkers are hired, have been suffering from the shortage of farm labors for years. Such a situation calls for a development of U.S. immigration …

Algae-Based Beneficial Re-Use Of Carbon Emissions Using A Novel Photobioreactor: A Techno-Economic And Life Cycle Analysis, Michael H. Wilson, Aubrey Shea, John Groppo, Czarena Crofcheck, David Quiroz, Jason C. Quinn, Mark Crocker

Center for Applied Energy Research Faculty and Staff Publications

Despite the many advantages of microalgae, the feasibility of large-scale cultivation requires significant amounts of carbon dioxide (CO2) to enable high growth rates. A synergistic union typically proposed for the supply of CO2 is the coupling of algal cultivation with emissions from power plants. This study investigates the sustainability of a novel microalgae platform coupled with coal-based flue gas. The proposed system consists of a novel photobioreactor (PBR) for the production of biomass followed by a two-stage dewatering process. A systems model, which quantifies the CO2 and energy consumption of the proposed system, was developed, and the minimum biomass selling …

How Does Occupational Licensing Affect Entry Into The Medical Field? An Examination Of Emts, Aaron Yelowitz, Samuel J. Ingram

Institute for the Study of Free Enterprise Working Papers

The COVID-19 pandemic has led to temporary suspensions of many occupational licensing laws, especially for health care professionals, in an effort to manage surges in health care demand. The crisis highlights more general concerns about occupational licensing laws, yet convincing empirical evidence on the degree to which such laws have inhibited entry into health care professions is scarce because most studies must rely on cross-sectional variation to identify such effects. In this study, we indirectly examine how occupational licensing affects the choice to become an Emergency Medical Technician (EMT) by exploiting the demand-side shock from the Affordable Care Act (ACA). …

Decreasing Test Anxiety In Nursing Students Using Cute/Funny Animal Videos, Lynn Kelso

DNP Projects

Abstract

Background: Stress, test anxiety and worry continue to increase in nursing students. As successful completion of course exams is required for nursing students to complete their program of study, these increased levels of stress, anxiety and worry can hinder their ability to perform at their best. Purpose: The aim of this project is to show that using cute/funny animal videos prior to an exam can decrease test anxiety (TA) and improve performance. Project Improvement Framework: The plan-do-study-act, PDSA, quality improvement framework was used for the final, modified project. Method: A video was embedded into three of …

Dietary Assessments And Their Association With Psychological Factors, Inflammation, And Cardiovascular Health Outcomes, Junghee Kang

Theses and Dissertations--Nursing

Cardiovascular diseases (CVDs), a group of disorders of the heart and blood vessels, are the leading cause of death worldwide, causing one-third of deaths each year. Diet is one of the most important behavioral risk factors for CVD. The effects of behavioral risk factors, such as diet, may lead to increased blood pressure, increased blood glucose, raised blood lipids, and overweight and obesity. Inflammation contributes to the development of CVD and can be influenced by diet. Dietary assessment indices can measure diet quality from an individual's dietary intake by scoring food and nutrient intakes. However, the mediation effects of diet …