Digital Commons Network^™

Dual-Functional Phosphorene Nanocomposite Membranes For The Treatment Of Perfluorinated Water: An Investigation Of Perfluorooctanoic Acid Removal Via Filtration Combined With Ultraviolet Irradiation Or Oxygenation, Joyner Eke, Lillian Banks, M. Abdul Mottaleb, Andrew J. Morris, Olga V. Tsyusko, Isabel C. Escobar

Internal Medicine Faculty Publications

Nanomaterials with tunable properties show promise because of their size-dependent electronic structure and controllable physical properties. The purpose of this research was to develop and validate environmentally safe nanomaterial-based approach for treatment of drinking water including removal and degradation of per- and polyfluorinated chemicals (PFAS). PFAS are surfactant chemicals with broad uses that are now recognized as contaminants with a significant risk to human health. They are commonly used in household and industrial products. They are extremely persistent in the environment because they possess both hydrophobic fluorine-saturated carbon chains and hydrophilic functional groups, along with being oleophobic. Traditional drinking water …

Using Authentic Online Resources In Russian For Stem Coursework For Novice Through Superior Level Learners, Molly T. Blasing

Modern and Classical Languages, Literatures and Cultures Faculty Publications

This article makes a case for incorporating STEM content into Russian language courses at the Novice through Superior levels of proficiency. The author presents models of asynchronous learning activities based on authentic online resources developed for a Russian for STEM pilot course taught during the COVID-19 pandemic. These lessons can be employed in online or face-to-face courses to prepare students to speak, read, write, and understand the language of STEM fields in Russian.

Primed For Addiction: A Critical Review Of The Role Of Microglia In The Neurodevelopmental Consequences Of Adolescent Alcohol Drinking, Jennifer K. Melbourne, Cassie M. Chandler, Catherine E. Van Doorn, Michael T. Bardo, James R. Pauly, Hui Peng, Kimberly Nixon

Psychology Faculty Publications

Alcohol is one of the most widely used recreational substances worldwide, with drinking frequently initiated during adolescence. The developmental state of the adolescent brain makes it vulnerable to initiating alcohol use, often in high doses, and particularly susceptible to alcohol-induced brain changes. Microglia, the brain parenchymal macrophages, have been implicated in mediating some of these effects, though the role that these cells play in the progression from alcohol drinking to dependence remains unclear. Microglia are uniquely positioned to sense and respond to central nervous system insult, and are now understood to exhibit innate immune memory, or “priming,” altering their future …

Effects Of Social Isolation On Perineuronal Nets In The Amygdala Following A Reward Omission Task In Female Rats, Dolores B. Vazquez-Sanroman, G. Arlington Wilson, Michael T. Bardo

Psychology Faculty Publications

Negative urgency is a facet of impulsivity associated with negative affect and risky behavior that may involve the amygdala. The current study determined if social isolation during development alters negative urgency and c-Fos activity in the basolateral amygdala (BLA). Female Sprague-Dawley rats were raised in an isolated condition (IC), a standard social condition (SC), or an enriched condition (EC) and then were tested for locomotor activity, novelty place preference, and negative urgency using a reward omission task. Following performance on the reward omission task, the brains were analyzed for c-Fos expression in Ca2+ /calmodulin kinase II (CaMKII) and calbindin (CB) …

Effects Of The Glucocorticoid Receptor Antagonist Pt150 On Stress-Induced Fentanyl Seeking In Male And Female Rats, Lindsey R. Hammerslag, Emily D. Denehy, Benjamin A. Carper, Tracy L. Nolen, Mark A. Prendergast, Michael T. Bardo

Psychology Faculty Publications

Rationale Opioid use disorder (OUD) is highly comorbid with stress-related disorders, and stress can serve as a trigger for reinstatement of drug seeking. Glucocorticoid receptor (GR) antagonists such as mifepristone (RU-486) may be effective against stress-induced drug seeking. In the current study, PT150 (formerly ORG-34517), a more selective GR antagonist, was tested using two models of stress-induced drug seeking, namely footshock and yohimbine.

Methods Adult male and female Sprague-Dawley rats were trained to self-administer fentanyl (2.5 μg/kg/infusion, i.v.) in a model of escalation. Rats then received 7 days of abstinence, followed by extinction; PT150 (0, 50 or 100 mg/kg in …

Prevalence And Exacerbation Of Asthma Within Two Counties In Eastern Kentucky, Rachid Souleye

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Central Appalachia residents have one of the highest rates of serious respiratory diseases in the nation. Appalachian Kentuckians are 50% more likely to be diagnosed with adult asthma compared to the overall U.S. population. Yet, few epidemiologic studies have assessed risk factors for respiratory disease in this population. Using a community-based approach, the investigators of the Mountain Air Project (MAP), one of the largest adult cohorts from two disadvantaged communities in Central Kentucky, collected data to estimate the prevalence of asthma and assess various socioeconomic and environmental risk factors to determine their effect on asthma.

Methods: A cross-sectional epidemiologic …

Injuries Among Distillery Workers: Workers' Compensation First Reports Of Injury, 2010-2019, Mira Hali Mirzaian

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

AIMS: To identify the most frequent type, nature, and cause of work-related injury amongst distillery workers as well as contributing factors to the injurious event in an effort to inform potential intervention.

METHODS: Workers’ Compensation First Reports of Injury (FROI) from the years 2010-2019 (N=974) were obtained. Variables were created for ‘occupational category’ and ‘accident description’ to assist in the elucidation of the injurious event. The Ratchet Circular Scan Test was used to assess seasonal variation in injury. Kernal Density Analysis was conducted to assess rates of injury by calendar year.

RESULTS: Amongst injured distillery workers, 908 of the injuries …

Rabies In Kentucky From 1989-2020: A Case For Surveillance, Sarah Jane Robbins

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Kentucky rabies reporting system includes data from five laboratories and provides an account of suspected rabies reports since 1989. Over 35,000 suspected cases are used to estimate rabies incidence temporally and spatially. Recommendations to the current rabies reporting methodologies are presented through proposed innovations of a standard, electronic reporting form. Given the multiple sources of data, the reporting system lacks standardization and comprehensive information about suspected rabies events, resulting in limited epidemiological capabilities; and data issues that prevent its use as a surveillance system. These issues are a limiting factor in rabies elimination; but a driving factor in over-testing, …

Comparison Of Differential Effects Of Interpolated And Intermittent Reinforcement On Extinction Resistance: A Simulated Study, Cara D. Baxter

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Schedules of reinforcement explain when a reinforcer may be delivered. Among the different schedules exists continuous (CRF), intermittent (INT), and extinction (EXT). When employing a CRF, reinforcement is delivered following every occurrence of the target response. An INT schedule includes varying the delivery of reinforcement. While both of these schedules include the delivery of reinforcement, EXT means that reinforcement is no longer delivered for the target response (Lee & Belfiore, 1997). Studies have shown that behaviors may be less resistant to extinction if moved from an INT schedule to a CRF schedule than if EXT followed the INT schedule alone. …

Factors Influencing Mare Milk And Foal Gastrointestinal Health, Morgan Brewer Pyles

Theses and Dissertations--Animal and Food Sciences

Foals are born lacking a functional microbial community in their gastrointestinal tract (GIT). However, these microbes quickly colonize after birth. Factors influencing the process of microbial colonization and health of the foal’s gastrointestinal tract, such as milk yield and composition, are not well understood. Milk contains non-lactose carbohydrates termed “oligosaccharides”, which serve as prebiotics in human neonates and may serve a similar function in foals. Three animal studies were conducted to evaluate factors influencing mare milk and digestive health in the foal. In experiment 1, bacteria were enumerated and identified in foal feces and the utilization of different carbohydrates by …

The Effect Of Endophyte-Infected Tall Fescue Seed Consumption On Gut And Satiety Hormones Related To Intake Regulation In Holstein Steers, Mindy Elizabeth King

Theses and Dissertations--Animal and Food Sciences

Cattle consuming endophyte-infected tall fescue (E+) typically experience a syndrome termed fescue toxicosis which is thought to be caused by ergot alkaloids produced by the endophyte. The most abundant alkaloid, and considered the most likely cause of the syndrome, is ergovaline (ERV). During fescue toxicosis, a decrease in ADG is observed which is likely due to the decrease in DMI commonly observed in animals consuming E+ compared to animals consuming non-endophyte-infected tall fescue (E-). However, the cause of the decrease in intake is not well elucidated. Many physiological responses control feed intake including, but not limited to, physical, neural, metabolic, …

Isolation Box Test (Ibt) And Dairy Calf Personality Traits Relationship With Performance Through Weaning, Megan Marie Woodrum Setser

Theses and Dissertations--Animal and Food Sciences

Personality tests are utilized to characterize individual differences in personality traits across species. Currently, there is no objective personality test that can be implemented on-farm to measure personality in dairy calves. Measuring personality of youngstock in the dairy industry may allow producers to utilize information on individual differences for management decisions and limit the investment in unfit individuals. The isolation box test is a personality test that has potential to be adapted and utilized for dairy calves. The main objective of this thesis is to develop, validate, and utilize an isolation box test for use on-farm in dairy calves. More …

New Evidence For P-Gp-Mediated Export Of Amyloid-Β Peptides In Molecular, Blood-Brain Barrier And Neuronal Models, Amanda B. Chai, Anika M. S. Hartz, Xuexin Gao, Alryel Yang, Richard Callaghan, Ingrid C. Gelissen

Sanders-Brown Center on Aging Faculty Publications

Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer’s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated peptides exit into the extracellular space where they deposit and propagate neurotoxicity. The ability for P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter, to export Aβ across the blood-brain barrier (BBB) has previously been reported. However, controversies surrounding the P-gp–Aβ interaction persist. Here, molecular data affirm that both Aβ₄₀ and Aβ₄₂ peptide isoforms directly interact with and are substrates of P-gp. This was reinforced ex vivo by the …

Corporate Misconduct In The Pharmaceutical Industry, Richard C. Ausness

Law Faculty Scholarly Articles

Sadly, many pharmaceutical companies have engaged in unethical or illegal behavior. The current opioid crisis is the most recent example of misconduct by pharmaceutical companies. Moreover, this pattern of conduct is neither rare, nor recent. Instead, it is long-standing and pervasive in nature. Furthermore, unlike wrongdoing by other businesses that cause primarily economic or environmental harm, wrongdoing by pharmaceutical companies, like that of asbestos or tobacco companies, may cause personal injuries and death on a large scale.

Question #1: Is There A Gender Gap In Performance On Multiple Choice Exams? A. Always B. Never C. Most Of The Time, Jane Bloom Grisé

Law Faculty Scholarly Articles

The correct answer to Question #1 is C. Most of the time, women score lower than men on multiple-choice exams. Question #2: How did you become interested in this topic?

A. The author likes to create multiple-choice tests.

B. The author does well on multiple-choice tests.

C. The author unexpectedly discovered this disparity.

The correct answer is C. I discovered this disparity unexpectedly and was surprised to find that women scored lower than men on multiple-choice exams and that multiple-choice exams underpredicted women's academic performance.

While educators might assume that different types of assessments such as multiple-choice and essays are …

Deodand, Brian L. Frye

Law Faculty Scholarly Articles

Law is a funny thing. Nobody really knows what it is. And there’s so much of it! If you started reading the United States Code out loud today, you’d be hoarse before you got to Title 17. Even still, you’d barely be getting started. The Library of Babel has nothing on the mountain of laws we’ve already got or the avalanche we keep creating. No one could possibly read them all, let alone remember what they say. What a conundrum!

And yet, as a practical matter, we still seem to have a pretty good idea of what the law expects …

Cartoon Contracts And The Proactive Visualization Of Law, Michael D. Murray

Law Faculty Scholarly Articles

Contracts have always relied on text first, foremost, and usually exclusively. Yet, this approach leaves many users of contracts in the dark as to the actual meaning of the transactional documents and instruments they enter into. The average contract routinely uses language that only lawyers, law-trained readers, and highly literate persons can truly understand.

There is a movement in the law in the United States and many other nations called the visualization of law movement that attempts to bridge these gaps in contractual communication by using highly visual instruments. In appropriate circumstances, even cartoons and comic book forms of sequential …

Plagiarism Pedagogy: Why Teaching Plagiarism Should Be A Fundamental Part Of Legal Education, Brian L. Frye, Megan E. Boyd

Law Faculty Scholarly Articles

As a practicing lawyer, if you aren’t plagiarizing, you’re committing malpractice. Litigators copy forms and arguments from winning briefs rather than bill their clients for reinventing the wheel. Transactional lawyers copy enforceable agreements to ensure their agreements are enforceable too. Partners routinely present documents prepared by associates (and sometimes even paralegals) as their own work. And judges are the most prolific plagiarists of all, copying briefs, opinions, treatises, and legal and nonlegal scholarship, adopting arguments from lawyers and holdings from other judges as their own and claiming authorship of opinions written primarily by their clerks or the parties to the …

Novel Tools For Analysis Of Disordered Sleep And Motor Behavior In Preclinical Models Of Disease, Dillon M. Huffman

Theses and Dissertations--Biomedical Engineering

Subtle changes in sleep architecture can accompany and be symptomatic of various diseases or disorders. Understanding the complex interactions between sleep and health requires the ability to characterize sleep, probe its underlying mechanisms through perturbation, and quantify dependent physiological outcomes. Rodent models have come to be accepted as a valuable tool for preclinical investigations. However, experimental tools to accomplish such research typically rely on laborious methods that limit throughput and flexibility. Thus, research tools that minimize workload could be of great value to the research community and expedite investigation of the underlying mechanisms of sleep and further the development of …

Facilitating Analysis Of Toxoplasma Gondii Bradyzoite Metabolic Activity Via Image Processing And Multivariate Logistic Regression For High Throughput Classification Of Mitochondrial Morphologies, Brooke Place

Theses and Dissertations--Biomedical Engineering

Approximately a third of the population worldwide is chronically infected by the parasite Toxoplasma gondii. During chronic infection the parasite resides within tissue cysts as the poorly understood bradyzoite form. Observation of these bradyzoites via microscopic imaging within tissue cyst purified from infected mouse brains has shown metabolic activity with heterogeneous replication potential. With fluorescence microscopy imaging targeting the parasite’s actively respiring mitochondria, the parasite’s metabolic state can be further investigated as the morphology of mitochondria can be associated with specific physiologic states. However, manually classifying mitochondrial morphologies from these images can be tedious and prone to error as …

Assessing Freeway Crash Risk Using Crowdsourced Waze Incident Alerts, Eugene Boasiako Antwi

Theses and Dissertations--Civil Engineering

Traffic data obtained through crowdsourcing are becoming more accessible to traffic agencies due to advancements in smartphone technology. Traffic managers aim to use this data to complement their conventional sources of data and provide additional context in their analysis. In this study, Waze incident alerts are integrated with GPS-Probe speed data and Kentucky State Police (KSP) crashes to assess their impact on traffic flow and safety on freeways in Kentucky. The analysis showed that the presence of a vehicle on the shoulder is associated with about 36.7% of freeway crashes in Kentucky. The presence of a vehicle on the shoulder …

Investigation Of Nitrate Transfer In Karst Basins During Storm Events Using Submersible Underwater Nutrient Analyzers, John Pike

Theses and Dissertations--Civil Engineering

Knowledge of nitrate sources and pathways in karst basins remains incomplete and hinders management of nutrients that cause algae blooms and degrade municipal water supply. However, the increased availability of optical, ultraviolet nitrate sensors allows advancement of nitrate source and transfer for water managers. A concept model is hypothesized for nitrate transfer during hydrologic events and baseflow that considers the multiple porosity of karst. To test the concept model, 15-minute nitrate sensor data is collected with submersible underwater nutrient analyzers over a multi-year period from two locations in a karst basin in the inner bluegrass region of central Kentucky, USA. …

Localization Of Stationary Source Of Floor Vibration Using The Steered Response Power Method, Mohammad Royvaran

Theses and Dissertations--Civil Engineering

If the generated vibration in a building exceeds the acceptable limit design for a floor system, it is necessary to identify the source of vibration, a process known as localization. The objective of this study is the localization of stationary vibration sources, and the approach used is the steered response power (SRP) method. This method has already been shown to work well for wireless and acoustical applications to locate transmitter and sound sources, respectively. To the writer’s knowledge, this study is the first application of the SRP method to locate vibration sources using floor vibration measurements. However, because waves behave …

Debilitating Debts And Recapacitating Loans: How Fintech Made Markets For Unsecured Consumer Debt Using Alternative Data And Machine Learning, Michael Joshua Mccanless

Theses and Dissertations--Geography

This thesis investigates the production and management of consumer debt on digital platforms. First, this study investigates how borrowers navigate spaces of debt and indebtedness created by fintech consumer lenders. Second, this thesis analyzes the process and impact of ‘alternative’ data and machine learning on fintech credit scoring models. As consumer lending ‘moves online’, this research analyzes the increasingly important role of digital spaces in the creation and management of debt. Tracking the interfaces and algorithms used by online consumer lenders, I weave together insight from digital and financial geographies to argue that digital technologies are enabling firms to marketize …

Reality And Ideology: The Use Of Gender Indexing Features In Reality Tv, Steven J. Gerencser

Theses and Dissertations--Linguistics

This article analyzes 4 episodes of the Japanese reality television program Terrace house: Aloha State for instances of gender indexing language to investigate the gap between actual speaker usage of these features and the linguistic ideology surrounding their usage as is perpetrated and perpetuated by media. Specifically, the gender indexing features which will be investigated to accomplish this are sentence final particles and first-person pronouns. Instances of these linguistic features are typically presented as features of gendered language, but as will be demonstrated, this does match their actual usage by speakers. I set out to answer three research questions, (1) …

"To Claim That Greatness For Themselves”: A History Of The Kentucky Horse Park, Emily Elizabeth Libecap

Theses and Dissertations--History

The Kentucky Horse Park describes itself as the world’s only equine theme park. However, the park is not entirely without historical precedent; instead, world’s fairs, amusement parks, and theme parks all form a century-long pedigree chart through which the park can trace its ancestors. The Kentucky Horse Park’s links to these predecessors deepen our understanding of how the park is a reflection of the world around it and the motivations for how and why it was built. From its inception in the late 1960s, to when it opened in 1978, through the present day, the Kentucky Horse Park was and …

A Holy Tug Of War: Us Christians Against The Contras (1970-1990), Mark Maxwell Brown

Theses and Dissertations--History

After the Sandinista revolution of 1979 ousted the longstanding Somoza dynasty of Nicaragua, the small Central American nation became an obsession of US foreign policy as the Reagan administration committed its efforts to deposing the leftist revolutionary government through the funding and training of the Contras, a counter-revolutionary guerrilla group. With the Cold War at a boiling point, continued control and influence over Central America became a pillar of US anticommunist agenda. Uniquely, many of the most ardent critics of the Reagan administration during this period of violent intervention were Christian missionaries. The Sandinistas were able to defeat the Somoza …

“They Did This Work”: Black Activism, Education, And The Rosenwald Rural School-Building Program In Kentucky, Le Datta Denise Grimes

Theses and Dissertations--History

This study examines what Black Kentuckians did on their own behalf to educate themselves in the early twentieth century. I argue that Black Kentuckians’ agency and activism formed the bedrock of the Rosenwald movement in Kentucky. From 1917 to 1932, they built 158 Rosenwald Schools across the Bluegrass by welding together multiple strategies of resistance. Such agitation included voluntarily taxing themselves, waging legal battles, deploying military-style fundraising campaigns, and building institutions to support their schools. Seeking first-class citizenship, they also volunteered labor, donated land, and bought supplies to uplift themselves and their community through education. This work took place against …

Making Sense Of The Divinely Beautiful: Essays On Friendship, Love, And Attraction, Michelle Catlin

Theses and Dissertations--Philosophy

Essay 1: As interpersonal communication has changed with the proliferation of technology-based forms of meeting and interacting with others, philosophers have begun considering ways in which these new types of communication have altered the landscape of our relationships. Although philosophers are split on whether online friendships can measure up to the Aristotelean standard of virtue friendship, none have questioned the importance of truth telling or accurate representation of oneself in the context of online sharing. The underlying assumption is that in a virtuous friendship, there is no role whatsoever for anything other than strict honestly. I disagree with this …

Stress, Burnout, And Well-Being In New Veterinary Graduates: Evaluating A Pilot Online Professional Development Program, Addie Rose Reinhard

Theses and Dissertations--Community & Leadership Development

Suicide, stress, and burnout are occurring at high rates among veterinary professionals, and the transition from student to practicing veterinarian has been shown to be a particularly stressful time. The aim of this study was to evaluate an online professional development program for new veterinary graduates incorporating peer social support and training in professional skills important for success in the transition to practice. In this mixed methods study, the program was evaluated qualitatively with focus group data and quantitatively by assessing knowledge gained and levels of stress, burnout, social support, and well-being. Seven new veterinary graduates participated in the program, …