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Mithramycin And Analogs For Overcoming Cisplatin Resistance In Ovarian Cancer, David Schweer, J. Robert Mccorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick R. Ueland, Jill M. Kolesar Jan 2021

Mithramycin And Analogs For Overcoming Cisplatin Resistance In Ovarian Cancer, David Schweer, J. Robert Mccorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick R. Ueland, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance. This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, …

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Abnormal Nutritive Sucking As An Indicator Of Neonatal Brain Injury, Sabrina Shandley, Gilson J. Capilouto, Eleonora Tamilia, David M. Riley, Yvette R. Johnson, Christos Papadelis Jan 2021

Abnormal Nutritive Sucking As An Indicator Of Neonatal Brain Injury, Sabrina Shandley, Gilson J. Capilouto, Eleonora Tamilia, David M. Riley, Yvette R. Johnson, Christos Papadelis

Communication Sciences and Disorders Faculty Publications

A term neonate is born with the ability to suck; this neuronal network is already formed and functional by 28 weeks gestational age and continues to evolve into adulthood. Because of the necessity of acquiring nutrition, the complexity of the neuronal network needed to suck, and neuroplasticity in infancy, the skill of sucking has the unique ability to give insight into areas of the brain that may be damaged either during or before birth. Interpretation of the behaviors during sucking shows promise in guiding therapies and how to potentially repair the damage early in life, when neuroplasticity is high. Sucking …

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The Use Of Once Daily Milking Of Dairy Cows To Achieve Economic And Social Sustainability On New Zealand Dairy Farms, David A. Clark, Dawn E. Dalley Jan 2021

The Use Of Once Daily Milking Of Dairy Cows To Achieve Economic And Social Sustainability On New Zealand Dairy Farms, David A. Clark, Dawn E. Dalley

IGC Proceedings (1977-2023)

No abstract provided.

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Effect Of Plant Patches On The Foraging Location Of Beef Cattle, Y. C. Zhou, Deli Wang, A. K. Xu, Z. F. Wang, H. Z. Yu Jan 2021

Effect Of Plant Patches On The Foraging Location Of Beef Cattle, Y. C. Zhou, Deli Wang, A. K. Xu, Z. F. Wang, H. Z. Yu

IGC Proceedings (1977-2023)

No abstract provided.

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Lamb Fattening On Mediterranean‐Like Pastures In Chile Versus Olive Oil Cake‐Based Rations, C. Aguilar, R. Vera, R. Lira, J. Quenaya, Fernando Squella, H. Yutronic, P. Toro, P. Perez, I. Briones Jan 2021

Lamb Fattening On Mediterranean‐Like Pastures In Chile Versus Olive Oil Cake‐Based Rations, C. Aguilar, R. Vera, R. Lira, J. Quenaya, Fernando Squella, H. Yutronic, P. Toro, P. Perez, I. Briones

IGC Proceedings (1977-2023)

No abstract provided.

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Integration Of Small Holder Crop‐Forage‐Livestock Systems In South East Asia--An Eastern Indonesian Case Study, Neil D. Macleod, Shaun Lisson, Cam Mcdonald, Jeff P. Corfield, Rachmat Rahman, Ketut Puspadi Jan 2021

Integration Of Small Holder Crop‐Forage‐Livestock Systems In South East Asia--An Eastern Indonesian Case Study, Neil D. Macleod, Shaun Lisson, Cam Mcdonald, Jeff P. Corfield, Rachmat Rahman, Ketut Puspadi

IGC Proceedings (1977-2023)

No abstract provided.

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A Study On Ningxia Desert Grassland (Stipa Breviflora) Utilization, Kechang Li, Xin Wu, Jinhua Wang, Zhao Yu Jan 2021

A Study On Ningxia Desert Grassland (Stipa Breviflora) Utilization, Kechang Li, Xin Wu, Jinhua Wang, Zhao Yu

IGC Proceedings (1977-2023)

No abstract provided.

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West African Dwarf Goat Milk Production And Composition Under Semi Intensive Management In Cameroon During The Dry Season, B. Boukila, E. Tedonkeng Pamo, F. A. Fonteh, F. Tendonkeng Jan 2021

West African Dwarf Goat Milk Production And Composition Under Semi Intensive Management In Cameroon During The Dry Season, B. Boukila, E. Tedonkeng Pamo, F. A. Fonteh, F. Tendonkeng

IGC Proceedings (1977-2023)

No abstract provided.

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Determination Of Animal Unit Weight In Rangelands Of Iran, Hossein Arzani, Mehdi Ghorbani, A. Nikkhah, Hossein Azarnivand Jan 2021

Determination Of Animal Unit Weight In Rangelands Of Iran, Hossein Arzani, Mehdi Ghorbani, A. Nikkhah, Hossein Azarnivand

IGC Proceedings (1977-2023)

No abstract provided.

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Seasonal Changes In Nutrient Intake Of Grazing Beef Cows On An Alpine Pasture In Japan, Masato Yayota, M. Nakano, R. Tamai, Shigeru Ohtani Jan 2021

Seasonal Changes In Nutrient Intake Of Grazing Beef Cows On An Alpine Pasture In Japan, Masato Yayota, M. Nakano, R. Tamai, Shigeru Ohtani

IGC Proceedings (1977-2023)

No abstract provided.

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Effects Of Concentrate Supplement On Intake And Weight Gain Of Grazing Lambs, Xiaoqing Zhang, Yanmei Jin, Risu Na, Qizhong Sun Jan 2021

Effects Of Concentrate Supplement On Intake And Weight Gain Of Grazing Lambs, Xiaoqing Zhang, Yanmei Jin, Risu Na, Qizhong Sun

IGC Proceedings (1977-2023)

No abstract provided.

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Effects Of Racing Surface And Turn Radius On Fatal Limb Fractures In Thoroughbred Racehorses, Michael L. Peterson, Wayne T. Sanderson, Nurlan Kussainov, Sarah Jane Hobbs, Patti Miles, Mary C. Scollay, Hilary M. Clayton Jan 2021

Effects Of Racing Surface And Turn Radius On Fatal Limb Fractures In Thoroughbred Racehorses, Michael L. Peterson, Wayne T. Sanderson, Nurlan Kussainov, Sarah Jane Hobbs, Patti Miles, Mary C. Scollay, Hilary M. Clayton

Biosystems and Agricultural Engineering Faculty Publications

North American Thoroughbred racing is conducted on three types of surfaces—dirt, turf, and synthetic. The tracks are oval, and races are run counterclockwise. The loading on right and left limbs is expected to differ as a function of turn radius, banking, surface, and gait asymmetry. Hind limbs and forelimbs also have different functions related to propulsion and turning, respectively. This study uses the Equine Injury Database for race starts from 1 January 2009 through 31 December 2014, to compare injury rates across participating North American racetracks. The data are limited to catastrophic injuries in which horses died or were euthanized …

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The Role Of Functional Plant In Sheep Foraging, Ling Wang, Guowei Chen, Xiao Shun, Deli Wang Jan 2021

The Role Of Functional Plant In Sheep Foraging, Ling Wang, Guowei Chen, Xiao Shun, Deli Wang

IGC Proceedings (1977-2023)

No abstract provided.

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Mitochondria Exert Age-Divergent Effects On Recovery From Spinal Cord Injury, Andrew N. Stewart, Katelyn E. Mcfarlane, Hemendra J. Vekaria, William M. Bailey, Stacey A. Slone, Lauren A. Tranthem, Bei Zhang, Samir P. Patel, Patrick G. Sullivan, John C. Gensel Jan 2021

Mitochondria Exert Age-Divergent Effects On Recovery From Spinal Cord Injury, Andrew N. Stewart, Katelyn E. Mcfarlane, Hemendra J. Vekaria, William M. Bailey, Stacey A. Slone, Lauren A. Tranthem, Bei Zhang, Samir P. Patel, Patrick G. Sullivan, John C. Gensel

Physiology Faculty Publications

The extent that age-dependent mitochondrial dysfunction drives neurodegeneration is not well understood. This study tested the hypothesis that mitochondria contribute to spinal cord injury (SCI)-induced neurodegeneration in an age-dependent manner by using 2,4-dinitrophenol (DNP) to uncouple electron transport, thereby increasing cellular respiration and reducing reactive oxygen species (ROS) production. We directly compared the effects of graded DNP doses in 4- and 14-month-old (MO) SCI-mice and found DNP to have increased efficacy in mitochondria isolated from 14-MO animals. In vivo, all DNP doses significantly exacerbated 4-MO SCI neurodegeneration coincident with worsened recovery. In contrast, low DNP doses (1.0-mg/kg/day) improved tissue …

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Population Dynamics Of Soil Microorganisms In Deteriorate Grassland In West Region Of China, Tuo Yao, D. G. Zhang, R. J. Long, L. Q. Xi Jan 2021

Population Dynamics Of Soil Microorganisms In Deteriorate Grassland In West Region Of China, Tuo Yao, D. G. Zhang, R. J. Long, L. Q. Xi

IGC Proceedings (1977-2023)

No abstract provided.

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Discussion The Signification Of Chinese Grassland Reclamation Reasons In The Historical Period, Miao Yang Jan 2021

Discussion The Signification Of Chinese Grassland Reclamation Reasons In The Historical Period, Miao Yang

IGC Proceedings (1977-2023)

No abstract provided.

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Analysis On The Rangeland Degenerate Gradient Of Bayanbulak, Xianhua Zhang, Shazhou An Jan 2021

Analysis On The Rangeland Degenerate Gradient Of Bayanbulak, Xianhua Zhang, Shazhou An

IGC Proceedings (1977-2023)

No abstract provided.

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Role Of Lab In Silage Fermentation: Effect On Nutritional Quality And Organic Acid Production—An Overview, Da Hye Kim, Kyung Dong Lee, Ki Choon Choi Jan 2021

Role Of Lab In Silage Fermentation: Effect On Nutritional Quality And Organic Acid Production—An Overview, Da Hye Kim, Kyung Dong Lee, Ki Choon Choi

Center for Research on Environmental Disease Faculty Publications

Lactic acid bacteria (LAB) inocula play a key role in the preservation and fermentation of forage crops within inoculated silages. LAB is a significant group of the bacterial community as they successfully reduce pH, inhibit the survival of undesirable microorganisms and control nutrient loss in fermented silage. Ensiled plants and metabolites such as simple plant carbohydrates have been utilized by LAB (homo-fermentative and hetero-fermentative LAB) to initiate the production of organic acids including lactic and acetic acids. LAB as a biological silage additive provides stable feed value and secondary metabolic products during rapid anaerobic primary silage fermentation. They are able …

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Effect Of Temperature On Heart Rate For Phaenicia Sericata And Drosophila Melanogaster With Altered Expression Of The Trpa1 Receptors, Nicole T. Marguerite, Jate Bernard, Douglas A. Harrison, David Harris, Robin L. Cooper Jan 2021

Effect Of Temperature On Heart Rate For Phaenicia Sericata And Drosophila Melanogaster With Altered Expression Of The Trpa1 Receptors, Nicole T. Marguerite, Jate Bernard, Douglas A. Harrison, David Harris, Robin L. Cooper

Biology Faculty Publications

The transient receptor potential (TrpA—ankyrin) receptor has been linked to pathological conditions in cardiac function in mammals. To better understand the function of the TrpA1 in regulation of the heart, a Drosophila melanogaster model was used to express TrpA1 in heart and body wall muscles. Heartbeat of in intact larvae as well as hearts in situ, devoid of hormonal and neural input, indicate that strong over-expression of TrpA1 in larvae at 30 or 37 °C stopped the heart from beating, but in a diastolic state. Cardiac function recovered upon cooling after short exposure to high temperature. Parental control larvae (UAS-TrpA1) …

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Modes Of Transmission Of Severe Acute Respiratory Syndrome-Coronavirus-2 (Sars-Cov-2) And Factors Influencing On The Airborne Transmission: A Review, Mahdieh Delikhoon, Marcelo I. Guzman, Ramin Nabizadeh, Abbas Norouzian Baghani Jan 2021

Modes Of Transmission Of Severe Acute Respiratory Syndrome-Coronavirus-2 (Sars-Cov-2) And Factors Influencing On The Airborne Transmission: A Review, Mahdieh Delikhoon, Marcelo I. Guzman, Ramin Nabizadeh, Abbas Norouzian Baghani

Chemistry Faculty Publications

The multiple modes of SARS-CoV-2 transmission including airborne, droplet, contact, and fecal–oral transmissions that cause coronavirus disease 2019 (COVID-19) contribute to a public threat to the lives of people worldwide. Herein, different databases are reviewed to evaluate modes of transmission of SARS-CoV-2 and study the effects of negative pressure ventilation, air conditioning system, and related protection approaches of this virus. Droplet transmission was commonly reported to occur in particles with diameter >5 µm that can quickly settle gravitationally on surfaces (1–2 m). Instead, fine and ultrafine particles (airborne transmission) can stay suspended for an extended period of time (≥2 h) …

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Concentrate With Different Protein Sources For Sheep Grazing Tifton 85 Pasture, S. R. B. Azevedo, P. R. C. Lins, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos Jan 2021

Concentrate With Different Protein Sources For Sheep Grazing Tifton 85 Pasture, S. R. B. Azevedo, P. R. C. Lins, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos

IGC Proceedings (1977-2023)

No abstract provided.

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Fatty Acid Profile Of Subcutaneous Fat In Lambs Finished On Either Olive Oil Cake‐Based Rations On Mediterranean‐Like Pastures In Chile, R. Vera, C. Aguilar, R. Lira, I. Peña, J. Quenaya, H. Yutronic, Fernando Squella, P. Toro, P. Perez, I. Briones Jan 2021

Fatty Acid Profile Of Subcutaneous Fat In Lambs Finished On Either Olive Oil Cake‐Based Rations On Mediterranean‐Like Pastures In Chile, R. Vera, C. Aguilar, R. Lira, I. Peña, J. Quenaya, H. Yutronic, Fernando Squella, P. Toro, P. Perez, I. Briones

IGC Proceedings (1977-2023)

No abstract provided.

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In Vivo Optical Metabolic Imaging Of Long-Chain Fatty Acid Uptake In Orthotopic Models Of Triple-Negative Breast Cancer, Megan C. Madonna, Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, Roujia Wang, Brian T. Crouch, Matthew D. Hirschey, Andrei Goga, Nirmala Ramanujam Jan 2021

In Vivo Optical Metabolic Imaging Of Long-Chain Fatty Acid Uptake In Orthotopic Models Of Triple-Negative Breast Cancer, Megan C. Madonna, Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, Roujia Wang, Brian T. Crouch, Matthew D. Hirschey, Andrei Goga, Nirmala Ramanujam

Biomedical Engineering Faculty Publications

Targeting a tumor’s metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is of particular importance, especially in breast cancer. Imaging techniques offer the opportunity to quantify nutrient use in preclinical tumor models to guide development of new drugs that restrict uptake or utilization of these nutrients. We describe a fast and dynamic approach to image fatty acid uptake in vivo and demonstrate its relevance to study both tumor metabolic reprogramming directly, as well as the effectiveness of drugs targeting lipid metabolism. Specifically, …

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Protein Roughages For Growing Goats, J. B. Moura Neto, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos, Luiz G. R. Pereira Jan 2021

Protein Roughages For Growing Goats, J. B. Moura Neto, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos, Luiz G. R. Pereira

IGC Proceedings (1977-2023)

No abstract provided.

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Rangeland Management And Livestock Production System In Changthang, Ladakh India, Phunchok Jan 2021

Rangeland Management And Livestock Production System In Changthang, Ladakh India, Phunchok

IGC Proceedings (1977-2023)

No abstract provided.

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Excess Extracellular K+ Causes Inner Hair Cell Ribbon Synapse Degeneration, Hong-Bo Zhao, Yan Zhu, Li-Man Liu Jan 2021

Excess Extracellular K+ Causes Inner Hair Cell Ribbon Synapse Degeneration, Hong-Bo Zhao, Yan Zhu, Li-Man Liu

Otolaryngology--Head & Neck Surgery Faculty Publications

Inner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy remains unclear. Here, we report that elevation of extracellular K+, which is a consequence of noise exposure, could cause IHC ribbon synapse degeneration and swelling. Like intensity dependence in noise-induced cochlear synaptopathy, the K+-induced degeneration was dose-dependent, and could be attenuated by BK channel blockers. However, application of glutamate receptor (GluR) agonists caused ribbon swelling but …

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Management Of The Sensitized Cardiac Transplantation Recipient, Michael Mazzei, Suresh Keshavamurthy, Olga Timofeeva, Yoshiya Toyoda Jan 2021

Management Of The Sensitized Cardiac Transplantation Recipient, Michael Mazzei, Suresh Keshavamurthy, Olga Timofeeva, Yoshiya Toyoda

Surgery Faculty Publications

Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means through which sensitization may be diagnosed, and highlight some of the new therapeutic options for managing the sensitized cardiac transplant patients.

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The Economical Evaluation Of The Grazing Management Project In A Part Of Grasslands In Isfahan Province, A. R. Mirsaidi, M. J. Aghasi Jan 2021

The Economical Evaluation Of The Grazing Management Project In A Part Of Grasslands In Isfahan Province, A. R. Mirsaidi, M. J. Aghasi

IGC Proceedings (1977-2023)

No abstract provided.

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Seasonal Faecal Production Potential Of Livestock Grazing Heterogenous Natural Range And Cropfields Of Semi‐Arid Nigeria, B. S. Malami, P. H. Y. Hiernaux, H. M. Tukur, J. Steinbach Jan 2021

Seasonal Faecal Production Potential Of Livestock Grazing Heterogenous Natural Range And Cropfields Of Semi‐Arid Nigeria, B. S. Malami, P. H. Y. Hiernaux, H. M. Tukur, J. Steinbach

IGC Proceedings (1977-2023)

No abstract provided.

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Study On The Characteristics Of Yak Meat In Different Domestic Types And Semi‐Wild Yak In Qinghai Plateau, X. L. Luo, Z. B. Tong, Z. J. Ma, Y. H. Ma Jan 2021

Study On The Characteristics Of Yak Meat In Different Domestic Types And Semi‐Wild Yak In Qinghai Plateau, X. L. Luo, Z. B. Tong, Z. J. Ma, Y. H. Ma

IGC Proceedings (1977-2023)

No abstract provided.

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