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The Hemp Controversy: Can Industrial Hemp Save Kentucky?, Susan David Dwyer

Kentucky Law Journal

No abstract provided.

The Frankenstein Controversy: The Constitutionality Of A Federal Ban On Cloning, Anne Lawton

Kentucky Law Journal

No abstract provided.

Fecal Coliform Transport Through Intact Soil Blocks Amended With Poultry Manure, S. W. Mcmurry, Mark S. Coyne, E. Perfect

Plant and Soil Sciences Faculty Publications

Poultry production in Kentucky increased almost 200% between 1991 and 1995. Their waste is typically land applied, and fecal pathogen runoff and infiltration may cause nonpoint source groundwater pollution. We looked at the preferential flow of fecal coliforms through undisturbed soil blocks since fecal bacteria typically infiltrate the soil profile to contaminate groundwater. Poultry manure was uniformly distributed on top of sod-covered or tilled (upper 12.5 cm) soil blocks and the blocks were irrigated. Drainage was collected in 100 uniformly spaced cells beneath each block and analyzed for fecal coliform content and drainage volume. The spatial distribution of drainage and …

8th Biennial Midwest/Midsouth Bankruptcy Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, Lawrence Ponoroff, Douglass G. Boshkoff, Tracey N. Wise, Christopher W. Frost, Keith M. Lundin, Ray Reynolds Graves, David G. Epstein, Joe Lee, Robert E. Mckenzie, Conrad K. Cyr

Continuing Legal Education Materials

Materials from the 8th Biennial Midwest/Midsouth Bankruptcy Institute held December 1997.

Nicotinic Receptor Antagonists In The Treatment Of Neuropharmacological Disorders, Peter A. Crooks, Linda P. Dwoskin, Alain Ravard

Pharmaceutical Sciences Faculty Patents

Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown to competitively inhibit dopamine release induced by nicotine. The nicotine analog compounds are useful in the treatment of nicotine abuse, smoking cessation therapy, as an antidote for nicotine intoxication, treatment of cognitive disorders such as Alzheimer's disease and for the treatment of Parkinson's disease.

Kentucky Transportation Cabinet: Annual Assessment Of Customer Needs And Satisfaction: Mail Survey, Patsy Anderson, Kris Hockensmith

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet, both through its own quality initiative and a statewide "Empower Kentucky" campaign, has a commitment to achieve new levels of quality in the development, construction and maintenance of highways. In order to gage progress, there is a need to establish a baseline of customer satisfaction with the current highway system, and determine needs as, perceived by the users of the highway system. As a result, the University of Kentucky Transportation Center, Technology Exchange Unit, was contracted to conduct a customer needs and satisfaction survey. The objectives of this study are to:

A. Ascertain Kentucky highway users' …

Role Of Egr-1 Gene Expression In B Cell Receptor-Induced Apoptosis In An Immature B Cell Lymphoma, Subramanian Muthukkumar, Seong-Su Han, Sumathi Muthukkumar, Vivek M. Rangnekar, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Ligation of B cell receptor (BCR) on BKS-2, an immature B cell lymphoma by anti-IgM antibodies (Ab) caused apoptosis. Here we report that signaling through B cell receptor in wild type BKS-2 cells down-regulated the expression of Egr-1, a zinc finger-containing transcription factor. A reduction in the level ofEgr-1 mRNA could be demonstrated as early as 30 min after the ligation of BCR on BKS-2 cells. Immunocytochemical and Western blot analysis revealed that the expression of EGR-1 protein was also inhibited by anti-IgM treatment. Antisense oligonucleotides to Egr-1 caused growth inhibition and apoptosis in BKS-2 cells, suggesting that …

Permeable, Non-Irritating Prodrugs Of Nonsteroidal And Steroidal Agents, Paul Ashton, Thomas J. Smith, Peter G. Glavinos, John D. Conklin, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska

Ophthalmology and Visual Science Faculty Patents

Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.

Spin Trapping Compounds, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions containing as the active ingredient a spin-trapping reagent, preferably α-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventing symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or α-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, …

Metabolically Inactive Insulin Analog Prevents Type I Diabetes In Prediabetic Nod Mice, Dennis G. Karounos, J. Scott Bryson, D. A. Cohen

Internal Medicine Faculty Publications

The purpose of this study was to determine the relative importance of the metabolic effects of insulin for diabetes prevention by administering insulin or an inactive insulin analog by daily subcutaneous injections to prediabetic mice. A recombinant monomeric human insulin analog, which does not bind to the insulin receptor as a consequence of an alteration of a single amino acid at position 25 of the B chain, was shown to be equally effective at diabetes prevention as was intact insulin. In contrast to native insulin, the insulin analog did not cause hypoglycemia after subcutaneous injection. The insulin analog, however, protected …

Potential Role Of Tnfα And Lipoprotein Lipase As Candidate Genes For Obesity, Philip A. Kern

Clinical and Translational Science Faculty Publications

To maintain body weight, metabolic efficiency was promoted during evolution; two candidate genes for body weight regulation are lipoprotein lipase (LPL) and tumor necrosis factor-α [TNFα). Human fat cells do not synthesize lipid, but rely on LPL-mediated plasma triglyceride hydrolysis. Adipose LPL is elevated in obesity. Following weight loss, LPL is elevated further, suggesting attempts to maintain lipid stores during fasting and to replenish lipid stores during refeeding. Muscle LPL is regulated inversely to adipose LPL. Thus, an increased adipose/muscle LPL ratio would partition dietary lipid into adipose tissue and would explain some of the variability in weight gain when …

Effect Of Bmp Implementation On Storm Flow Quality Of Two Northwestern Arkansas Streams, Dwayne R. Edwards, Tommy C. Daniel, H. Don Scott, Phillip A. Moore Jr., John F. Murdoch, Paul F. Vendrell

Biosystems and Agricultural Engineering Faculty Publications

The effectiveness of management practices in improving quality of runoff from agricultural land areas has been reported based primarily on results from plot- and field-scale studies. There is limited information available on watershed scales, particularly when the dominant agricultural land use is pasture. The objective of this study was to determine whether a program of Best Management Practice (BMP) implementation in the Lincoln Lake watershed of northwestern Arkansas was effective in reducing storm stream flow concentrations and mass transport of nitrate nitrogen (NO₃-N), ammonia nitrogen (NH₃-N), total Kjeldahl nitrogen (TKN), ortho-phosphorus (PO₄-P), total phosphorus …

Identification Of A Gal/Galnac Lectin In The Protozoan Hartmannella Vermiformis As A Potential Receptor For Attachment And Invasion By The Legionnaires' Disease Bacterium, Chandrasekar Venkataraman, Bradley J. Haack, Subbarao Bondada, Yousef Abu Kwaik

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The Legionnaire's disease bacterium, Legionella pneumophila, is a facultative intracellular pathogen which invades and replicates within two evolutionarily distant hosts, free-living protozoa and mammalian cells. Invasion and intracellular replication within protozoa are thought to be major factors in the transmission of Legionnaire's disease. Although attachment and invasion of human macrophages by L. pneumophila is mediated in part by the complement receptors CR1 and CR3, the protozoan receptor involved in bacterial attachment and invasion has not been identified. To define the molecular events involved in invasion of protozoa by L. pneumophila, we examined the role of protein tyrosine phosphorylation …

Intrinsic And Extrinsic Control Of Hemopoietic Stem Cell Numbers: Mapping Of A Stem Cell Gene, Gerald De Haan, Gary Van Zant

Markey Cancer Center Faculty Publications

We evaluated in vivo interactions between extrinsic (growth factor induced) and intrinsic (genetically determined) effectors of mouse primitive hemopoietic stem cell proliferation and numbers. Accordingly, stem cell frequency and cell cycle kinetics were assessed in eight strains of inbred mice using the cobblestone area–forming cell (CAFC) assay. A strong inverse correlation was observed between mouse lifespan and the number of autonomously cycling progenitors (CAFC day 7) in the femur. The population size of primitive stem cells (CAFC day 35) varied widely (up to sevenfold) among strains, unlike total CAFC day 7 numbers (cycling and quiescent), which were similar. Administration of …

Method For Employing The Delta Opioid Dadle To Extend Tissue Survival Time During Ischemia, Sufan Chien

Surgery Faculty Patents

This invention concerns a method for extending the survival time of mammalian lung tissue subjected to ischemia, by which said tissue is perfused with a preservation solution comprising a therapeutic dose of the delta opioid DADLE ([D-Ala²,D-Leu⁵]-Enkephalin) under hypothermic conditions.

Using Geotextiles For Feeding And Traffic Surfaces, Larry W. Turner

Agricultural Engineering Extension Publications

Mud robs Kentucky beef and dairy producers of performance from their cattle herds in winter and spring. To help avoid the problems associated with mud and reduced performance, producers should consider using concrete pads or lower-cost all-weather surfaces wherever animals congregate (e.g., feeding areas, animal traffic areas, and loafing areas). Although concrete is probably the most desirable surface for durability and low maintenance, an all-weather surface can be constructed of geotextile fabric, rock, and fine surface cover for less than one-third of the cost of concrete. Rock over bare soil in Kentucky requires approximately 12 inches of depth for stability, …

Psychic Unity Constraints Upon Successful Intercultural Communication, James M. Donovan, Brian A. Rundle

Law Faculty Scholarly Articles

This article begins with the unchallenged assertion that intercultural communication episodes are necessarily imperfect. The disciplinary corpus reflects the correct assumption that much of this failure is attributable to the lock of various competencies on the part of the communicants. Experts become vague, however, where the line should be drawn, if at all, beyond which increased competency will not yield improved communication.

The principle of psychic unity assures us that there will be some experiences (not many, but some) which are so far removed from the ordinary processes of categorization and conceptualization that the raw data cannot be encapsulated faithfully …

Aminoalkylpyridine Compounds Which Are Useful As Anticonvulsant Drugs, Excitatory Amino Acid Inhibitors And Nmda Sigma Receptor Antagonists, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Pharmaceutical compositions comprise as the active ingredient potent orally active, nonneurotoxic anticonvulsant compounds that are excitatory amino acid and NMDA/sigma receptor antagonists . . .

To read the remainder of this abstract, please download this patent.

The Role Of Religion In Public Life And Official Pressure To Participate In Alcoholics Anonymous, Paul E. Salamanca

Law Faculty Scholarly Articles

If religion is an innate aspect of the human experience, it should not be surprising that Alcoholics Anonymous (A.A.), a widely known and arguably religious support group for problem drinkers, has become a common and effective means of combating alcoholism. Also, it should not be surprising that probation officers, parole officers, judges, bar overseers, wardens, and myriad others exercising state authority routinely push individuals toward A.A. Arguably, however, official referral of problem drinkers to A.A. violates current interpretations of the Establishment Clause because of the quasi-religious nature of the program.

Although separationism helps both church and state, our Constitution does, …

Regulation Of The Rat Liver Sodium-Dependent Bile Acid Cotransporter Gene By Prolactin. Mediation Of Transcriptional Activation By Stat5, Tanmoy C. Ganguly, Michelle L. O'Brien, Saul J. Karpen, James F. Hyde, Fredrick J. Suchy, Mary Vore

Toxicology and Cancer Biology Faculty Publications

The intracellular mechanism(s) underlying the upregulation of the hepatic Na+/taurocholate cotransporting polypeptide (ntcp) by prolactin (PRL) are unknown. In this report, we demonstrate a time-dependent increase in nuclear translocation of phosphorylated liver Stat5 (a member of the ignal ransducers and ctivators of ranscription family) that correlated with suckling-induced increases in serum PRL levels. In electrophoretic mobility gel shift assays, nuclear Stat5 exhibited specific DNA-binding ability towards IFN-gamma-activated sequence (GAS)-like elements (GLEs; 5'TTC/A-PyNPu-G/TAA-3') located in the -937 to -904 bp region of the ntcp promoter. Transient cotransfections in HepG2 cells revealed that PRL inducibility (2.5-3-fold) required coexpression of the long form …

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Many different disorders can be treated using these compounds, including diseases or disorders of the central …

Interview: Cindi Katz. Creating Safe Space And The Materiality Of The Margins, Vincent Delcasino, Michael L. Dorn, Carole Gallaher

disClosure: A Journal of Social Theory

No abstract provided.

Anti-Idiotype Monoclonal Antibody 1a7 And Use For The Treatment Of Melanoma And Small Cell Carcinoma, Malaya Chatterjee, Kenneth A. Foon

Microbiology, Immunology and Molecular Genetics Faculty Patents

The present invention relates isolation of anti-idiotypic antibody 1A7 raised against anti-GD2 mAb 14G2a and its use for the treatment of melanoma and small cell carcinoma. The antibody may be used as a substitute for isolated purified GD2 antigen in any appropriate application.

Neuroprotective Action Of Cycloheximide Involves Induction Of Bcl-2 And Antioxidant Pathways, Katsutoshi Furukawa, Steven Estus, Weiming Fu, Robert J. Mark, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Publications

The ability of the protein synthesis inhibitor cycloheximide (CHX) to prevent neuronal death in different paradigms has been interpreted to indicate that the cell death process requires synthesis of “killer” proteins. On the other hand, data indicate that neurotrophic factors protect neurons in the same death paradigms by inducing expression of neuroprotective gene products. We now provide evidence that in embryonic rat hippocampal cell cultures, CHX protects neurons against oxidative insults by a mechanism involving induction of neuroprotective gene products including the antiapoptotic gene bcl-2 and antioxidant enzymes. Neuronal survival after exposure to glutamate, FeSO₄, and amyloid β-peptide …

Grazing Alfalfa In Tennessee: Experiences And Opportunities, Gary Bates

Kentucky Alfalfa and Stored Forage Conference

Animal agriculture in the southeastern U.S. is based on forages. This area has the advantage over all other sections of the nation in forage production. From Kentucky to south Florida, with a little planning forage can be grown almost 12 months a year. Forage programs in Tennessee and Kentucky are based primarily around cool-season grasses such as tall fescue and orchardgrass. These grasses grow over a long portion of the year. In fact, producers have to deal with excess forage production during the spring and fall (Fig. 1). The quality and quantity of forage during these times of the year …

Alfalfa Hay: Quality Makes The Difference, Garry D. Lacefield, Jimmy C. Henning

Kentucky Alfalfa and Stored Forage Conference

Alfalfa "Queen of the Forage Crops" is one of the most important forage legumes grown in the U.S. It can be grown over a wide range of soil and climatic conditions, it has the highest yield potential and the highest feeding values of all adapted perennial forage legumes. Alfalfa is a versatile crop which can be used for pasture, hay, silage, green-chop, soil improvements and · human consumption (sprouts, etc.).

Transgenic Mice Which Overexpress Nerve Growth Factor, Kathryn M. Albers, Brian M. Davis

Neuroscience Faculty Patents

Transgenic mice that express increased levels of nerve growth factor (NGF) in the epidermis and other stratified, keratinized epithelium. The nerve growth factor expressing transgenic mice are useful in the study of neurodegenerative disorders of the brain such as Parkinson's syndrome and Alzheimer's disease and for testing for drug candidates for the treatment of these diseases.

Establishment Of Kura And Red Clover On A Soil And Mine Spoil, David C. Ditsch, Michael Collins, Norman L. Taylor

Agronomy Notes

Numerous benefits result from the addition of forage legumes to livestock diets. Superior nutritive value and intake of legume forage generally increase individual animal productivity compared with grass alone. This is particularly important with tall fescue where dilution of the diet with legumes can partially alleviate toxicosis associated with endophyte fungus infected fescue (Acremonium coenophialum). Unfortunately, short-term persistence of most legumes requires periodic reestablishment, adding to the cost of forage production and complicating pasture management.

Out Of Sight, Out Of Mind: Recovering The History Of Cockfighting In Kentucky, Joseph R. Jones

The Kentucky Review

No abstract provided.

The Criminal Law Implications Of The Human Genome Project: Reimagining A Genetically Oriented Criminal Justice System, Steven I. Friedland

Kentucky Law Journal

No abstract provided.