Digital Commons Network^™

Method For Enhancing Protective Cellular Responses To Genotoxic Stress In Skin, Elaine L. Jacobson, Myron Jacobson

Graduate Center for Nutritional Sciences Faculty Patents

The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. The invention further relates to pharmaceutical compositions comprising pro-NAD agents that effectively elevate intracellular NAD content. Finally, the invention relates to the method of using the pro-NAD agents to treat disorders such as sunburn and other skin deterioration that results from DNA damage in skin cells.

Beyond The State: The Return To Anarchy, Jeff Shantz

disClosure: A Journal of Social Theory

No abstract provided.

Entre Amigos / Among Friends, Patricia L. Price

disClosure: A Journal of Social Theory

No abstract provided.

Editor's Preface, Jessica Hollis

disClosure: A Journal of Social Theory

No abstract provided.

Liberalism And The Challenge Of Fight Club: Notes Toward An American Theory Of The Good Life, Christopher M. Duncan

disClosure: A Journal of Social Theory

No abstract provided.

The Animal: Other Civility And Animality In And Beyond Heidegger, Levinas, And Derrida, Donald L. Turner

disClosure: A Journal of Social Theory

No abstract provided.

Separate Stories, Common Myth: Disclosure Interviews Martin E. Marty, Walter Bower, Jonathan Vincent

disClosure: A Journal of Social Theory

No abstract provided.

Seventeen Amino Acid Peptide (Peptide P) For Treating Ischemia And Reperfusion Injury, Peter R. Oeltgen, Mark S. Kindy

Molecular and Cellular Biochemistry Faculty Patents

Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-Phe-His-Ser-Ile-NH2, is useful to treat ischemia.

Forage News [2003-04], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forage News Loss – College of Agriculture Gain
• Forage News Reflections
• Kentucky Grazing School
• Forages for Goats
• The Meat Goat and Cattle Consortium
• Upcoming Events

What Gets Judges In Trouble, Richard H. Underwood

Law Faculty Scholarly Articles

I wrote this article to collect some cautionary material about “what gets judges in trouble.” I wanted something I could offer to our state judges, practitioners, and my legal ethics students. While I have never been a judge, and while I have never worked for a judicial conduct organization, I have been a law professor for almost twenty-five years and the chairman of a state bar association ethics committee for fourteen. I am not the kind of person who would refrain from holding forth just because I may not know what I am talking about.

When I started out, I …

The Development Of Relationships Between Constituent Concentrations And Generic Hydrological Variables, Carmen T. Agouridis, Dwayne R. Edwards

Biosystems and Agricultural Engineering Faculty Publications

The collection and analysis of samples from storm events constitutes a large portion of the effort associated with water quality research. Estimating concentrations or loads from these events is often difficult. The equipment necessary to analyze the samples and the required laboratory resources are typically significant expenses incurred by the researcher. One potential method to reduce these costs is through the development of generic relationships between concentrations and easily measured variables such as dimensionless flow rate or time. The benefits recognized from such an effort include a reduction in the number of required samples, resulting in a reduction in cost. …

Glucuronidation Enzymes, Genes And Psychiatry, Jose De Leon

Psychiatry Faculty Publications

The phase I cytochrome P450 (CYP) isoenzymes have received substantial attention in the pharmacogenetic literature. Researchers are beginning to examine the role of the phase II UDP-glucuronosyltransferase (UGT) enzymes, which produce products that are more water-soluble, less toxic and more readily excreted than the parent compounds. Several reasons may have contributed to neglect of UGTs (compared to CYPs) including: (1) the overlapping activity of UGTs and lack of selective probes; (2) the complexity of the glucuronidation cycle; and (3) the difficulty in developing analytic methods to measure glucuronides. Current CYP knowledge is used as a model to predict advances in …

Producing Quality Alfalfa Hay, Jimmy C. Henning, Garry D. Lacefield

Kentucky Alfalfa and Stored Forage Conference

Hay is one of the most versatile of stored forages in that (1) it can be kept for long periods of time with little loss of nutrients if protected from weather; (2) a large number of crops can be successfully used for hay production; (3) it can be produced and fed in small or large amounts; (4) it can be harvested, stored and fed by hand or the production and feeding can be completely mechanized; and (5) hay can supply most nutrients needed by many classes of livestock. Hay is, therefore, the most commonly used stored feed on most farms.

Buying And Selling Alfalfa Hay, Garry D. Lacefield, Jimmy C. Henning

Kentucky Alfalfa and Stored Forage Conference

Alfalfa hay is an important agricultural product. Although often fed on the farms where it is produced, much alfalfa hay is also sold as a cash crop. It often constitutes a major source of income for those who sell it, or a major expense for those who buy it. Such transactions involve billions of dollars nationwide each year.

Alfalfa, The Queen Of Forage Crops — Reflections After Sixty Years Experience With The Crop, Warren C. Thompson

Kentucky Alfalfa and Stored Forage Conference

Yes, it is true I have been involved with alfalfa for 60 years and then some. Fact is I was fortunate enough to pick the World's best forage on which to base much of my career about the same time I fell in love with and married the best lady I ever knew. Betty has stuck with me through these crazy wonderful years. She was largely responsible for matters at home and raising the family. She managed our family and home while I was on the move trying to encourage maybe even coerce farmers in Kentucky and then over the …

Advances In Developing Better Alfalfa Varieties, Jim Moutray

Kentucky Alfalfa and Stored Forage Conference

Alfalfa breeders continue to actively pursue the development of varieties that will bring more benefits to farmers. Yield and better persistence are our highest priorities. Other traits under selection can make alfalfa easier and cheaper to grow, better and safer for livestock and more attractive to livestock.

The goal of this paper is to update you on the types of alfalfa research going on in the U.S., time tables on when you may expect to see these new developments and how they may help you in your operation.

Alfalfa Hay Quality: Terms And Definitions, Garry D. Lacefield

Kentucky Alfalfa and Stored Forage Conference

At the 22^nd Kentucky Alfalfa Conference we discussed the relationship among Alfalfa - Yield-Quality-Persistence. In our presentation, we indicated that all three components must be considered for best management of alfalfa stands. Over the past week, I have looked through the past twenty-two years of Alfalfa Conference Proceedings. It's interesting, but not surprising that we have focused far more attention on yield than on quality and/or persistence.

Alfalfa yield (quantity) and quality are both important; however, it is easier for producers to recognize problems associated with quantity than quality because quantity can be easily assessed visually. Thus, forage quantity …

Hiv Protease Inhibitors Promote Atherosclerotic Lesion Formation Independent Of Dyslipidemia By Increasing Cd36-Dependent Cholesteryl Ester Accumulation In Macrophages, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Richard N. Greenberg, Theresa Guerin, David Meade, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Melinda E. Wilson, Eric J. Smart

Physiology Faculty Publications

Protease inhibitors decrease the viral load in HIV patients, however the patients develop hypertriglyceridemia, hypercholesterolemia, and atherosclerosis. It has been assumed that protease inhibitor–dependent increases in atherosclerosis are secondary to the dyslipidemia. Incubation of THP-1 cells or human PBMCs with protease inhibitors caused upregulation of CD36 and the accumulation of cholesteryl esters. The use of CD36-blocking antibodies, a CD36 morpholino, and monocytes isolated from CD36 null mice demonstrated that protease inhibitor–induced increases in cholesteryl esters were dependent on CD36 upregulation. These data led to the hypothesis that protease inhibitors induce foam cell formation and consequently atherosclerosis by upregulating CD36 and …

Bridged Nicotine Compounds For Use In The Treatment Of Cns Pathologies, Peter A. Crooks, Linda P. Dwoskin, Rui Xu, Vladimir P. Grinevich

Pharmaceutical Sciences Faculty Patents

Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) having selective antagonist properties at α3β2-containing nicotinic receptor subtypes, and compositions containing these compounds. The compounds and compositions are used to treat central nervous system pathologies.

Kentucky Water Resources Research Institute Annual Technical Report Fy 2002, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The FY 2002 Annual Technical Report for Kentucky consolidates reporting requirements of the Section 104(b) base grant award in a single technical report that includes: 1) a synopsis of each research project supported during the period, 2) a list of related reports, 3) a description of information transfer activities, 4) a summary of student support during the reporting period, and 5) notable achievements and awards during the year.

Forage News [2003-01], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Happy New Year!
• Regional Grazing Conference Coming to Hannibal, Missouri
• Oops!!!
• Organic Agriculture Depends on Inorganic Nutrients
• 23^RD Alfalfa Conference Set for February 20
• Upcoming Events

Pharmaceutical Patents And Trips: A Comparison Of India And South Africa, Stephen Barnes

Kentucky Law Journal

No abstract provided.

Toward Getting Beyond The Blame Game: A Critique Of The Ideology Of Voluntarism In Title Vii Jurisprudence, Sandi Farrell

Kentucky Law Journal

No abstract provided.

The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar: A Toxicokinetic/Statistical Analysis With Clinical, Epidemiologic, And Mechanistic Implications, Manu Sebastian, Marie G. Gantz, Thomas Tobin, J. Daniel Harkins, Jeffrey M. Bosken, Charlie Hughes, Lenn R. Harrison, William V. Bernard, Dana L. Richter, Terrence D. Fitzgerald

Maxwell H. Gluck Equine Research Center Faculty Publications

During 2001, central Kentucky experienced acute transient epidemics of early and late fetal losses, pericarditis, and unilateral endophthalmitis, collectively referred to as mare reproductive loss syndrome (MRLS). A toxicokinetic/statistical analysis of experimental and field MRLS data was conducted using accelerated failure time (AFT) analysis of abortions following administration of Eastern tent caterpillars (ETCs; 100 or 50 g/day or 100 g of irradiated caterpillars/day) to late-term pregnant mares. In addition, 2001 late-term fetal loss field data were used in the analysis. Experimental data were fitted by AFT analysis at a high (P < .0001) significance. Times to first abortion (“lag time”) and abortion rates were dose dependent. Lag times decreased and abortion rates increased exponentially with dose. Calculated dose × response data curves allow interpretation of abortion data in terms of “intubated ETC equivalents.” Analysis suggested that field exposure to ETCs in 2001 in central Kentucky commenced on approximately April 27, was initially equivalent to approximately 5 g of intubated ETCs/day, and increased to approximately 30 g/day at the outbreak peak. This analysis accounts for many aspects of the epidemiology, clinical presentations, and manifestations of MRLS. It allows quantitative interpretation of experimental and field MRLS data and has implications for the basic mechanisms underlying MRLS. The results support suggestions that MRLS is caused by exposure to or ingestion of ETCs. The results also show that high levels of ETC exposure produce intense, focused outbreaks of MRLS, closely linked in time and place to dispersing ETCs, as occurred in central Kentucky in 2001. With less intense exposure, lag time is longer and abortions tend to spread out over time and may occur out of phase with ETC exposure, obscuring both diagnosis of this syndrome and the role of the caterpillars.

Joseph A. Altsheler And The Great Ghost Forest Of Kentucky, Mervyn Nicholson

The Kentucky Review

No abstract provided.

Library Notes: Selected Acquisitions [V. 15, No. 2], James D. Birchfield

The Kentucky Review

No abstract provided.

The Role Of Oxidative Stress In Alzheimer's Disease, Robin Petroze

Kaleidoscope

Over four million individuals in the United States currently suffer from Alzheimer's disease (AD), a devastating disorder of progressive dementia. Within the next several decades, AD is expected to affect over 22 million people globally. AD can only be definitively diagnosed by postmortem examination. Thus, investigation into the specific pathogenesis of neuronal degeneration and death in AD on a biochemical level is essential for both earlier diagnosis and potential treatment and prevention options. Overproduction of amyloid [3-peptide (A[3) in the brain leads to both free radical oxidative stress and toxicity to neurons in AD. My undergraduate biochemical studies with regard …

Anorexia, Bulimia, And Crayfish (Or, Why I Study The Pharmacology Of Serotonin Receptors In Glutamatergic Invertebrate Systems), Garrett Sparks

Kaleidoscope

No abstract provided.

Uk Undergraduate Research Program, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

Manganese Distribution Across The Blood-Brain Barrier. I. Evidence For Carrier-Mediated Influx Of Managanese Citrate As Well As Manganese And Manganese Transferrin, Janelle S. Crossgrove, David D. Allen, Bonny L. Bukaveckas, Susan S. Rhineheimer, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Manganese (Mn) is an essential element and a neurotoxicant. Regulation of Mn movement across the blood–brain barrier (BBB) contributes to whether the brain Mn concentration is functional or toxic. In plasma, Mn associates with water, small molecular weight ligands and proteins. Mn speciation may influence the kinetics of its movement through the BBB. In the present work, the brain influx rates of ⁵⁴Mn²⁺, ⁵⁴Mn citrate and ⁵⁴Mn transferrin (⁵⁴Mn Tf) were determined using the in situ brain perfusion technique. The influx rates were compared to their predicted diffusion rates, which were determined from …