Digital Commons Network^™

The Economics Of Integrating Crop Land To Mig Grazing, Edward N. Ballard

Kentucky Grazing Conference

Illinois soils vary in their properties and producing capacities. Large areas of the state have soils that are among the most productive in the world. Other areas have soils that, because they are too steep or droughty or have some other undesirable features, are not the most productive for corn and soybeans.

However, over the past 30 years there has been a trend to place more acres in Illinois in corn and soybeans and less acres in small grains, legumes and pasture crops. Government incentive programs have encouraged more acres to be place into corn and soybean production.

Environmental Benefits With Improved Grazing, David Stipes

Kentucky Grazing Conference

The public is becoming better educated about the environment and will continually question activities that are perceived as being harmful to soil, water, air, plants, people, animals and other concerns. Livestock producers who implement well-planned grazing management systems have an excellent opportunity to compliment both production and natural resource conservation considerations. All segments of the population involved in production agriculture will be held accountable for environmental impacts that result from their operation. A proactive approach is needed by livestock and other agricultural producers to sustain the protection of the environment that is in harmony with a healthy ecosystem. All those …

Grazing Systems For Beef Cattle, John Johns

Kentucky Grazing Conference

Beef cattle represent the most important grazing livestock enterprise to Kentucky producers. As of January 1, 2003 there were 1,120,000 producing beef brood cows on 39,000 farms in the state. In addition, more than 600,000 yearling cattle are also produced. The number of total beef animals is increasing as producers put more economic reliance on beef and forage programs. In many cases, beef cattle represent the only practical method of converting high quality forage to income for producers.

Grazing Systems For Dairy, Donna M. Amaral-Phillips

Kentucky Grazing Conference

Forages which are grazed can provide anywhere from 25 to 100% of the forage consumed by growing dairy heifers, dry cows or the milking herd. In this paper, I would like to specifically deal with devising a grazing program for a dairy lactating or milking herd. Lactating dairy cows are a “high performance animal” and, as such, any decreases in the availability or quality of forage can quickly decrease milk production. Thus, the goal when designing a grazing system is to provide adequate quantities of high-quality, vegetative forage to prevent decreases in performance. These decreases in performance occur in all …

Optimize Grazing--Minimize Stored Feed, Garry D. Lacefield

Kentucky Grazing Conference

The title “Optimize Grazing – Minimize Stored Feed” appears to be a bit redundant at first glance. Indeed if we optimize grazing, we will certainly minimize the amount of stored feed required to winter our animals. Putting both concepts together can serve as a reminder of the tremendous benefit of both.

Grazing represents the cheapest source of nutrients for our beef industry. Several studies have shown that the best predictor of profitability in the beef industry is cost of stored feed. In Kentucky, specifically, that means cost/amount of hay required to winter on beef animals.

Pharmaceutical Formulation For Poorly Water Soluble Camptothecin Analogues, Tiang-Xiang Xiang, Bradley D. Anderson

Pharmaceutical Sciences Faculty Patents

The present invention provides a general method to retard the precipitation inception time for poorly water-soluble camptothecin analogues from a supersaturated solution by a chemical conversion approach via pH alteration. This method is successfully utilized to prepare stable parenteral formulations for silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin (DB-67), a poorly water-soluble lipophilic camptothecin analogue, in aqueous solutions containing β-cyclodextrin sulfobutyl ether (SBE-CD) or other solubilizing agents. The formulations manufactured by this method are more simple and cost-effective, of higher doses and better quality in terms of manufacture loss and formulation stability, and can be free of organic solvents (e.g., DMSO or N-methyl-2-pyrrolidinone).

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Forage News [2003-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• 4^TH Kentucky Grazing Conference in Lexington
• Buttercup Control in Cool-Season Grass Pastures
• Does “Endophyte” in Stockpiled Tall Fescue Impact Animal Performance?
• Upcoming Events

19th Annual Environmental Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 19th Annual Environmental Law Institute held by UK/CLE in November 2003.

Forage News [2003-10], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Illinois Animal Scientist to Speak at Kentucky Grazing Conference
• KFGC Awards: Deadline October 15
• Fighting Tall Fescue Toxicity: Is There a Silver Bullet?
• Forage Extension Position
• Performance of Grazing-Tolerant Alfalfa Varieties Rotationally Grazed by Dairy Cattle
• The Most Important Invention in 2000 Years?
• Last Call for October Grazing School
• A Long, Rich History
• Evaluating Hay Quality
• Upcoming Events

Evaluation Of Methods To Protect Water Quality In Karst Areas: Phase I, Jennifer Webster, Dhandayudhapani Ramalingam, Sudhir Palle

Kentucky Transportation Center Research Report

The primary focus of this report is two-fold; to provide a literature review on what has been previously learned about highway runoff in relation to karsts aquifers and to characterize a karsts highway site in Kentucky that can be used to evaluate a variety of best management practices. From research findings, the main sources of pollutants in highway runoff came from vehicles, atmospheric fallout, and precipitation. The behavior of pollutants and their interaction with the environment can dictate where they will be found and how to best minimize their effects. Although it would seem that traffic volumes would greatly influence …

Pathogen- Or Elicitor-Inducible Transcription Regulatory Element From The Tobacco 5-Epi-Aristolochene Synthase Gene And Plants Transformed Therewith, Joseph Chappell, Shaohui Yin, Catherine Cornett

Pharmaceutical Sciences Faculty Patents

A tobacco epi-5-aristolochene synthase transcriptional regulatory element functional in plants, plant tissue and in plant cells for pathogen inducible gene expression and a method for increasing the transcriptional expression of downstream genetic information in plants, plant tissue and plant cells are disclosed.

Vegf164-Mediated Inflammation Is Required For Pathological, But Not Physiological, Ischemia-Induced Retinal Neovascularization, Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Shiro Amano, Yuichiro Ogura, Tetsuo Hida, Yoshihisa Oguchi, Jayakrishna Ambati, Joan W. Miller, Evangelos S. Gragoudas, Yin-Shan Ng, Patricia A. D'Amore, David T. Shima, Anthony P. Adamis

Ophthalmology and Visual Science Faculty Publications

Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF₁₆₄ increased to a greater degree than during physiological neovascularization. Furthermore, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiological, neovascularization. When a VEGF₁₆₄-specific neutralizing aptamer was administered, it potently suppressed the leukocyte adhesion and pathological neovascularization, whereas it had little or no effect on physiological neovascularization. In parallel experiments, genetically altered VEGF_{164 …}

Forage News [2003-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forages at KCA
• Seeding Cool Season Grasses
• Tall Fescue Response to Nitrogen Fertilization for Stockpiled Grazing
• Extending the Grazing Season
• Round Bale Silage
• Does Grazing Management Impact the Production and Winter Survival of Annual Ryegrass?
• Upcoming Events

Forage News [2003-07], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• UK All Commodity Field Day
• Intensive Hay Conditioning Systems
• South Central Kentucky Agriculture Field Day
• Fructans in Pasture Grasses and Implications for Equine Laminitis in Kentucky
• Hybrid and Protein Supplement Affect Gains of Cattle Grazing Mature Corn
• Crop Options for an Expanding Dairy Farm in Wisconsin
• Kentucky Ranks in Top 20
• Upcoming Events

Adiponectin Expression From Human Adipose Tissue: Relation To Obesity, Insulin Resistance, And Tumor Necrosis Factor-Α Expression, Philip A. Kern, Gina B. Di Gregorio, Tong Lu, Negah Rassouli, Gouri Ranganathan

Clinical and Translational Science Faculty Publications

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI2were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (S_I) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from S_I, subjects who were discordant for S_I were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of …

Neuronal Cell Model And Methods Of Use Thereof, Craig S. Miller, Robert J. Jacob, Robert J. Danaher

Microbiology, Immunology and Molecular Genetics Faculty Patents

We previously described a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells that allows for inducible virus replication upon forskolin and heat stress (HS) treatment. In this research, we further characterized the model with respect to HSV-2 strain 333. We found that: (i) ND-PC12 cells are non-permissive to HSV-2 replication; (ii) HSV-2 can establish a quiescent infection, like HSV-1, in ND-PC12 cells with the transient use of acycloguanosine (ACV); however unlike HSV-1, anti-viral conditions are not obligatory to establish and maintain a quiescent state; (iii) the quiescent state is maintained …

Kentucky River Basin: Unified Long-Range Water Resources Plan. Executive Summary, Lindell E. Ormsbee, Malissa Mcalister

KWRRI Research Reports

No abstract provided.

Forage News [2003-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Plant and Soil Sciences Field Day
• Kentucky Grazing School
• KFGC Elects New Board Members
• Hay Temperature
• The Influence of Solar Radiation and Vapor Gradient on Alfalfa Hay Drying Rates
• Approximate Diet Selection of Grazing Animals When Offered in a Mixed Pasture
• Designer Milk
• Upcoming Events

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Transdemal Delivery Of Opioid Antagonist Prodrugs, Audra L. Stinchcomb, Peter W. Swaan

Pharmaceutical Sciences Faculty Patents

A composition, a method and an apparatus for transdermally delivering an effective amount of opioid antagonists derived from prodrugs for treatment of eating disorders, narcotic dependence and alcoholism. In addition, the present invention relates to a composition, a method and an apparatus for transdermally delivering an effective amount of an opioid and opioid antagonist derived from an opioid agonist and one of an opioid antagonist and a prodrug for treatment of pain.

Is Hp1 An Rna Detector That Functions Both In Repression And Activation?, Rebecca Kellum

Biology Faculty Publications

Heterochromatin is defined as regions of compact chromatin that persist throughout the cell cycle (Heitz, 1928). The earliest cytological observations of heterochromatin were followed by ribonucleotide labeling experiments that showed it to be transcriptionally inert relative to the more typical euchromatic regions that decondense during interphase. Genetic studies of rearrangements that place euchromatic genes next to blocks of heterochromatin also pointed out the repressive nature of heterochromatin (Grigliatti, 1991; and references therein). The discovery of the heterochromatin-enriched protein heterochromatin protein 1 (HP1) by Elgin and co-workers in the mid-1980s suggested that the distinct cytological features of this chromatin may be …

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Forage News [2003-05], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Losses and Drying Rates of Different Conditioners
• UK Robinson Station Host All Commodity Field Day
• Impact of Alfalfa Cutting Height on Yield and Quality
• Kentucky Plays Prominent Role at National Level
• Cool Season Pastures and Meat Goat Interaction
• Relationship Between Yield and Quality
• Upcoming Events

Assessment And Modeling Of Stream Mitigation Procedures [2003], Bernadette S. Dupont, Sudhir Palle

Kentucky Transportation Center Research Report

As population increases, so does the need to improve and augment the road network. Construction of new roadways or modification of existing roads often requires diversion or modification of streams. If a stream is disturbed, government regulations require mitigation or compensatory replacement of the affected area in a similar environment. Stream mitigation is of particular importance in Kentucky, as Kentucky ranks second in the United States for having the most miles of waterways. Consequently, stream mitigation has become a significant factor in roadway construction costs. To date, no studies have been made to assess the execution of the mitigation plans …

Assessing The Benefits Of Misting–Cooling Systems For Growing/Finishing Swine As Affected By Environment And Pig Placement Date, Thomas C. Bridges, Larry W. Turner, Richard S. Gates, Douglas G. Overhults

Biosystems and Agricultural Engineering Faculty Publications

The NCPIG swine growth model was used to evaluate swine growth performance for Wilmington, North Carolina; Bardstown and Mayfield, Kentucky; and Oklahoma City, Oklahoma as influenced by the use of a misting–cooling system. Five pig placement dates (Julian days 106, 126, 146, 166, and 186) were evaluated for each location using 22 years of weather data (1978–1999). The use of a misting system, while quite variable, was found to be generally profitable, reducing the length of the time to reach market weight. As the placement date increased, the average return to misting ($/pig/year) decreased from $8.12 to $1.98 for Oklahoma …

Hdl-Associated Estradiol Stimulates Endothelial No Synthase And Vasodilation In An Sr-Bi–Dependent Manner, Ming Gong, Melinda E. Wilson, Thomas Kelly, Wen Su, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Theresa Guerin, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Eric J. Smart

Pediatrics Faculty Publications

Cardiovascular diseases remain the leading cause of death in the United States. Two factors associated with a decreased risk of developing cardiovascular disease are elevated HDL levels and sex — specifically, a decreased risk is found in premenopausal women. HDL and estrogen stimulate eNOS and the production of nitric oxide, which has numerous protective effects in the vascular system including vasodilation, antiadhesion, and anti-inflammatory effects. We tested the hypothesis that HDL binds to its receptor, scavenger receptor class B type I (SR-BI), and delivers estrogen to eNOS, thereby stimulating the enzyme. HDL isolated from women stimulated eNOS, whereas HDL isolated …

Roadway Lighting And Driver Safety, Eric R. Green, Kenneth R. Agent, Monica L. Barrett, Jerry G. Pigman

Kentucky Transportation Center Research Report

The objectives of this project were to: a) analyze the safety benefits associated with roadway lighting; b) determine the design of the lighting installation necessary to provide an adequate level of lighting; c) investigate how lighting affects the driver and the roadway’s surrounding environment; d) review the economic correlation between effective lighting and cost savings for the State; e) provide input for updating the current section on street and highway lighting in the Traffic Guidance Manual; and f) analyze crash data to identify nighttime high crash locations. The procedure involved a literature search, a survey of states, crash data analysis, …

Addressing The Decline In Reproductive Performance Of Lactating Dairy Cows: A Researcher’S Perspective, William J. Silvia

Animal and Food Sciences Faculty Publications

No abstract provided.