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Articles 2731 - 2760 of 7872
Full-Text Articles in Entire DC Network
Substituted 2-Hydroxy-4-(2-(Phenylsulfonamido)Acetamido)Benzoic Acid Analogs As Inhibitors Of Stat Proteins (Us), James Turkson, Patrick Gunning
Substituted 2-Hydroxy-4-(2-(Phenylsulfonamido)Acetamido)Benzoic Acid Analogs As Inhibitors Of Stat Proteins (Us), James Turkson, Patrick Gunning
UCF Patents
In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Synthetic Mammalian Neuromuscular Junction And Method Of Making (Us), James Hickman, Xiufang Guo
Synthetic Mammalian Neuromuscular Junction And Method Of Making (Us), James Hickman, Xiufang Guo
UCF Patents
The next generation of system biology and drug discovery tools will be functional in vitro systems composed of human cells in defined serum-free systems. These functional in vitro systems will enable understanding beyond the single cell level directly to the human condition and enable the faster and least expensive translation of basic research to therapeutics. This study reports the first pure human-based in vitro Neuromuscular Junction (NMJ) system by demonstrating the co-culture of motoneurons and skeletal muscle (SKMs) derived from human stem cells, in a defined, serum-free medium and on a patternable non-biological surface.
Creating A Knowledge Map For The Research Lifecycle, Sai Deng, Xiao Hu
Creating A Knowledge Map For The Research Lifecycle, Sai Deng, Xiao Hu
Faculty Scholarship and Creative Works
In this study, a Knowledge Map (KM) was created based on the Research Lifecycle at the University of Central Florida to provide campus-wide services and resources to researchers. The KM aims to meet the needs of researchers and delivers guided searching and assistance in all aspects of research, including literature review, citation management, research data management, grant management, research work publication and dissemination. It elaborates the research processes and their associated services as presented in the Research Lifecycle, and links these points to various campus resources including those provided by the University Libraries, the Office of Research and Commercialization, the …
Method Of Myelinating Isolated Motoneurons, James Hickman
Method Of Myelinating Isolated Motoneurons, James Hickman
UCF Patents
One of the most significant interactions between Schwann cells and neurons is myelin sheath formation. Myelination is a vertebrate adaptation that enables rapid conduction of action potentials without a commensurate increase in axon diameter. In vitro neuronal systems provide a unique modality to study both factors influencing myelination and diseases associated with myelination. Currently, no in vitro system for motoneuron myelination by Schwann cells has been demonstrated. This work details the myelination of motoneuron axons by Schwann cells, with complete node of Ranvier formation, in a defined in vitro culture system. This defined system utilizes a novel serum-free medium in …
Aqueous Method For Making Magnetic Iron Oxide Nanoparticles Con, J. Manuel Perez Figueroa, Sudip Nath
Aqueous Method For Making Magnetic Iron Oxide Nanoparticles Con, J. Manuel Perez Figueroa, Sudip Nath
UCF Patents
The invention discloses an aqueous method of making polymer coated superparamagnetic nanoparticles. The method comprises providing a mixture of iron salts in an aqueous solution of hydrochloric acid. A solution of ammonium hydroxide is added to the mixture and stirred. Stirring continues with an aqueous solution of one or more biocompatible polymers so as to promote formation of polymer coated iron nanoparticles in suspension, wherein optionally at least one of the polymers in the coating may be aminated. Centrifuging the suspension leaves a supernatant without large particles. Filtering the supernatant through an ultrafiltration membrane and collecting the filtrate recovers polymer …
Method Of Co-Culturing Mammalian Muscle Cells And Motoneurons, James Hickman, Mainak Das
Method Of Co-Culturing Mammalian Muscle Cells And Motoneurons, James Hickman, Mainak Das
UCF Patents
The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (DETA); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons …
Silicon Photonic Fiber And Method Of Manufacture, Guifang Li, Fatih Yaman
Silicon Photonic Fiber And Method Of Manufacture, Guifang Li, Fatih Yaman
UCF Patents
The method of fabricating silicon photonic crystal fiber is innovative in that it is a conversion process, rather than the traditional drawing process. It leverages on the recently-established silica silicon photonic crystal fiber technology and newly discovered magnesiothemic reduction processes.
Methods And Compositions For Inhibiting The Proliferation Of Cancer Cells (Div), Ratna Chakrabarti
Methods And Compositions For Inhibiting The Proliferation Of Cancer Cells (Div), Ratna Chakrabarti
UCF Patents
A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an mRNA encoding LIM kinase 1; and introducing the oligonucleotide into the cancer cell, wherein the oligonucleotide decreases the expression of LIM kinase 1 in the cancer cell. The method also provides compositions of an antisense RNA LIM kinase 1 that can be administered to an individual for the purpose of inhibiting a protein kinase pathway and which further comprises methods for treating and monitoring the proliferation and …
Functionalized Nanoceria Composition For Ophthalmic Treatment Div 2, Sudipta Seal, Manas Haldar, Sanku Mallik, Swanand Patil
Functionalized Nanoceria Composition For Ophthalmic Treatment Div 2, Sudipta Seal, Manas Haldar, Sanku Mallik, Swanand Patil
UCF Patents
The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.
Cerium-Oxide-Nanoparticle-Based Device For The Detection Of Reactive Oxygen Species And Monitoring Of Chronic Inflammation Div, J. Manuel Perez Figueroa, Atul Asati, Charalambos Kaittanis, Santimukul Santra
Cerium-Oxide-Nanoparticle-Based Device For The Detection Of Reactive Oxygen Species And Monitoring Of Chronic Inflammation Div, J. Manuel Perez Figueroa, Atul Asati, Charalambos Kaittanis, Santimukul Santra
UCF Patents
polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. In one embodiment, the unit is a structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of the fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. In a second embodiment, a single chamber device consisting …
The Use Of Drug Therapy For Attention Deficit Hyperactivity Disorder (Adhd) In The Management Of Oppositional Defiant Disorder (Odd): A Literature Review, Shaina Flowers
HIM 1990-2015
Children with oppositional defiant disorder (ODD) and a concurrent Axis I diagnosis are often prescribed drug therapy for attention deficit hyperactivity disorder (ADHD) to manage disruptive behavior. However, ODD symptoms tend to be poorly controlled, raising questions about the effectiveness of drug therapy in children with the condition. Safety and long term consequences of pharmacological agents for ODD are important factors clinicians must consider before initiating treatment. The purpose of this literature review is to examine the pharmacodynamics and efficacy of drug therapy used for ODD in school-age children and adolescents. Additionally, awareness of poor behavior patterns and recognition of …
The Acquisition Of Student Nurses' Knowledge Of Genetics And Genomics And Attitudes Toward The Application Of Their Knowledge In Clinical Practice, Theresa Munroe
HIM 1990-2015
BACKGROUND: Nurses have the opportunity to bring a unique perspective to genetic and genomic healthcare through their emphasis of health promotion, prevention, screening, caring, and patient, family, and community relationships. Nurses are expected to have genetic and genomic knowledge that can be integrated into clinical practice. However, researchers today are finding nursing students are not competent or comfortable in the clinical applications of genetics and genomics, even though these students will soon be working in healthcare as it advances in these fields. The purpose of this research was to evaluate the genetic and genomic knowledge of nursing undergraduate students and …
The Effect Of Dietary Interventions On Fetal Birth Weights In Pregnant Adolescents: A Systematic Review, Seeta Nath
The Effect Of Dietary Interventions On Fetal Birth Weights In Pregnant Adolescents: A Systematic Review, Seeta Nath
HIM 1990-2015
Nutrition status during adolescent pregnancy and childbearing is a complex, multifaceted condition that can impact the health status of the teen mother and her baby. Adolescent mothers are at higher risk for low birth weight infants because of the unique dietary requirements needed to accommodate for both the growth needs of the adolescent mother and her unborn child. The purpose of this research was to examine dietary interventions that have the greatest effect on fetal birth weight outcomes in adolescent mothers. Secondly, this study explored dietary nutrients effective in reducing the likelihood of complications commonly associated with low birth weight …
Determining The Minimum Number Of Individuals And Significance Of The Kuelap Ossuary In Chachapoyas, Peru, Vu Tran
HIM 1990-2015
The pre-Hispanic archaeological site of Kuelap in Chachapoyas, Peru, is representative of the variation in mortuary practices observed throughout the Chachapoya region. The goal of this study was to analyze the human skeletal remains excavated in the center of the Circular Platform between residential structures at Kuelap by creating an inventory of the remains (n=2,573) and determine the minimum number of individuals originally interred in the mortuary context. This study observed a total of 171 femora, 159 humeri, 74 calcanei, 110 ilium bones, 86 temporal bones, and 74 maxillae. Results show that this mortuary context was an ossuary of secondarily, …
Effects Of Relaxed Assumptions On The State Switching Technique, Stephen Ilardi
Effects Of Relaxed Assumptions On The State Switching Technique, Stephen Ilardi
HIM 1990-2015
This thesis explores the effects of two assumptions commonly used in mathematical models related to a piezoelectric damping method known as State Switching. The technique relies on changing the stiffness state of a piezoelectric patch through control of the electrical boundary conditions. The transition between stiffness states is assumed to occur instantaneously and in concurrence with the switch event. In actuality, the transition will occur over a finite time and will trail behind the switch event by a finite time. For these assumptions to be valid, the effects of switch duration and delay on the performance of the State Switching …
Modeling Financial Markets Using Concepts From Mechanical Vibrations And Mass-Spring Systems, Michael Gandia
Modeling Financial Markets Using Concepts From Mechanical Vibrations And Mass-Spring Systems, Michael Gandia
HIM 1990-2015
This thesis describes a method of modeling financial markets by utilizing concepts from mechanical vibration. The models developed represent multi-degree of freedom, mass-spring systems. The economic principles that drive the design are supply and demand, which act as springs, and shareholders, which act as masses. The primary assumption of this research is that events cannot be predicted but the responses to those events can be. In other words, economic stimuli create responses to a stock’s price that is predictable, repeatable and scientific. The approach to determining the behavior of various financial markets encompassed techniques such as Fast Fourier Transform and …
Activatable Nanoprobes For Intracellular Drug Delivery, Swadeshmukul Santra, James Turkson
Activatable Nanoprobes For Intracellular Drug Delivery, Swadeshmukul Santra, James Turkson
UCF Patents
An activatable nanoprobe is provided having a core component and an active agent associated with the core component via a bond configured to be cleaved upon exposure to an endogenous compound.
Compositions For Treating Or Delaying The Onset Of Hair Loss (Us), Kiminobu Sugaya, Stephanie Merchant
Compositions For Treating Or Delaying The Onset Of Hair Loss (Us), Kiminobu Sugaya, Stephanie Merchant
UCF Patents
Disclosed herein are novel methods and compositions for treating and/or preventing hair loss in patients. Specifically exemplified herein are compositions containing a modified pyrimidine that are topically applied to a scalp of an patient. Typically, the patient has androgenic alopecia, alopecia greata, postpartum alopecia or telogen effluvium.
Methods And Materials For Stimulating Proliferation Of Stem Cells (Div), Sudipta Seal, Kiminobu Sugaya
Methods And Materials For Stimulating Proliferation Of Stem Cells (Div), Sudipta Seal, Kiminobu Sugaya
UCF Patents
Disclosed herein are methods and materials for influencing proliferation of stem cells. Specifically exemplified herein are compositions comprising cerium oxide nanoparticles which can be used to stimulate proliferation of stem cells under common culture conditions, or which can be utilized to improve therapeutic outcomes.
Methods And Products For Reawakening Retrocyclins, Alexander Cole
Methods And Products For Reawakening Retrocyclins, Alexander Cole
UCF Patents
Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., HIV-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell.
Two-Photon Absorbing Water-Soluble Fluorescent Probe As A Near-Neutral Ph Indicator, Kevin Belfield, Sheng Yao
Two-Photon Absorbing Water-Soluble Fluorescent Probe As A Near-Neutral Ph Indicator, Kevin Belfield, Sheng Yao
UCF Patents
The dynamics of intracellular pH is believed to be crucial for understanding the regulation mechanism of many physiological functions. Of the several methods avaible to detmermine pH, optical methods have several advantages including rapid response time, high signal-to-noise ratio, noninvasive, and excellent pH sensitivity. Since the first use of trapped intracellular pH probe, 6-carboxyfluorecein, was described by Thomas et al., a large number of pH indicators have been reported. SEE DISCLOSURE
Stem Cell Banking System, Kiminobu Sugaya, Angel Alvarez
Stem Cell Banking System, Kiminobu Sugaya, Angel Alvarez
UCF Patents
The creation of specialized embryonic stem cell lines is a valuable tool for research and discovery. However, the large cost of production and ethical concerns over ESC lines limits their future development. We propose the creation of specialized cell types from somatic cells.
Degradation Of Tatp, Tnt, And Rdx Using Mechanically Alloyed Metals, Christian Clausen, Rebecca Fidler, Michael Sigman, Cherie Yestrebsky
Degradation Of Tatp, Tnt, And Rdx Using Mechanically Alloyed Metals, Christian Clausen, Rebecca Fidler, Michael Sigman, Cherie Yestrebsky
UCF Patents
Bimetallic alloys, such as iron nickel (FeNi), iron palladium (FePd), and magnesium palladium (MgPd) provide in situ catalyst system fo remediating and degrading nitro and peroxide explosive compounds. Specifically, 2,4,6-trinitrotoluene (TNT), cyclo-1,3,5-trimethylene-2,4,6-trinitramine RDX), triacetone triperoxide (TATP), nitrocellulose and nitroglycerine which are contaminants in ground water, soil, and other structures can be treated on site to remediate explosive contamination.
Coarse Grained Monte Carlo Simulation Of The Self-Assembly Of The Hiv-1 Capsid Protein, Jeffrey Weber
Coarse Grained Monte Carlo Simulation Of The Self-Assembly Of The Hiv-1 Capsid Protein, Jeffrey Weber
HIM 1990-2015
In this study, a Monte Carlo simulation was designed to observe the self-assembly of the HIV-1 capsid protein. The simulation allowed a coarse grained model of the capsid protein with defined interaction sites to move freely in three dimensions using the Metropolis criterion. Observations were made as to which parameters affected the assembly the process. The ways in which the assembly were affected were also noted. It was found that proper dimerization of the capsid protein was necessary in order for the lattice to form properly. It was also found that a strong trimeric interface could be responsible for double-layered …
The Use Of Stable Isotopes To Assess Potential Effects Of Algal Blooms On Seagrass And Macroalgae Communities In The Indian River Lagoon, Florida, Alexandra Azcona
The Use Of Stable Isotopes To Assess Potential Effects Of Algal Blooms On Seagrass And Macroalgae Communities In The Indian River Lagoon, Florida, Alexandra Azcona
HIM 1990-2015
Algal blooms have caused significant losses in seagrass and macroalgae in the Indian River Lagoon, FL. To gain an understanding of these effects, samples of Gracilaria sp., Halodule wrightii, pinfish, and white mullet were taken throughout October and November of 2013. Samples from 2001 of Gracilaria sp., Halodule wrightii, Syringodium filiforme, Thalassia testudinum, pinfish, spotted seatrout, and white mullet were also obtained. Stable isotope data were obtained from these samples and compared by year and species. Halodule wrightii and pinfish had a significantly larger 2013 [delta]C13 values. Halodule wrightii also displayed lower total %C and total %N averages for 2013 …
Sexual Offender Treatment: A Paradigm Analysis Of Academic Journals, Vijay Chillar
Sexual Offender Treatment: A Paradigm Analysis Of Academic Journals, Vijay Chillar
HIM 1990-2015
Many criminologists and psychologists have theorized the possible causes behind an individual who engages in sex offenses; some of which will be reviewed. Through this paradigm analysis, I hope to identify how each discipline addresses the causes of sex offending and what treatments they offer in response to their theories. Additionally, this thesis will examine the Good Lives, Relapse Prevention, and the Risks, Need, Responsivity (RNR) models of treatment. The main objective of this thesis is to address the different facets of sex offending, so that the importance of finding an effective treatment model can be understood. By raising awareness …
The Incompatibility Of Freedom Of The Will And Anthropological Physicalism, Ariel Gonzalez
The Incompatibility Of Freedom Of The Will And Anthropological Physicalism, Ariel Gonzalez
HIM 1990-2015
Many contemporary naturalistic philosophers have taken it for granted that a robust theory of free will, one which would afford us with an agency substantial enough to render us morally responsible for our actions, is itself not conceptually compatible with the philosophical theory of naturalism. I attempt to account for why it is that free will (in its most substantial form) cannot be plausibly located within a naturalistic understanding of the world. I consider the issues surrounding an acceptance of a robust theory of free will within a naturalistic framework. Timothy O’Connor’s reconciliatory effort in maintaining both a scientifically naturalist …
Exploring The Correlation Between Theory Of Mind And Drive For Thinness, Sarah Hudak
Exploring The Correlation Between Theory Of Mind And Drive For Thinness, Sarah Hudak
HIM 1990-2015
Research suggests that, similar to individuals with an Autism Spectrum Disorder, people with Anorexia Nervosa demonstrate an inability to utilize Theory of Mind concepts. Theory of Mind allows healthy control populations to attribute mental states to others by accurately predicting and understanding the behavior of others. This study's intent was to further explore the relationship between eating disorders and Theory of Mind. Using an online survey management system (Qualtrics), 210 female students from a large metropolitan southeastern university completed the Drive for Thinness subscale of the Eating Disorder Inventory and the Reading the Mind in the Eyes task. It was …
A Model Of Hip Dysplasia Reductions In Infants Using The Pavlik Harness, Wissam Hadri
A Model Of Hip Dysplasia Reductions In Infants Using The Pavlik Harness, Wissam Hadri
HIM 1990-2015
Hip dysplasia, also known as congenital dysplasia of the hip (CDH) or Developmental Dysplasia of the Hip (DDH), is a mal-alignment of the hip joint. Left untreated within the first nine months, DDH could lead to permanent disability. Luckily however, this condition is diagnosed at an early age and is usually treated without surgery through the use of the Pavlik harness. In this thesis, a 3D computational model and dynamic finite element analysis of the muscles and tissues involved in hip dysplasia and the mechanics of the Pavlik harness, as rendered by Dr. Alain J. Kassab’s research group in the …
Panua Partners In Hope, Naivasha, Kenya: Legal And Domestic Related Challenges, Keisha Holman
Panua Partners In Hope, Naivasha, Kenya: Legal And Domestic Related Challenges, Keisha Holman
HIM 1990-2015
The complexities of issues existing in Kenya create a domino effect directly affecting not only the effective management and economic growth of Kenya, but also social and legislative constraints to the lower socioeconomic classes. Land dispossession, proof of ownership to property and nationality are ongoing troubling issues affecting increased orphans and vulnerable children (OVC) in Kenya, most noticeably within predominantly poverty stricken rural enclaves. This research focuses on the bold move of stakeholders of Trinity United Methodist Church in Naivasha, Kenya partnering with First United Methodist Church of Winter Park, Orlando, United States of America. In 2010, they conceptualized Panua …