Digital Commons Network^™

Synthesis Of Fluorene-Based Derivatives, Characterization Of Optical Properties And Their Applications In Two-Photon Fluorescence Imaging And Photocatalysis, Grace Githaiga

Electronic Theses and Dissertations

The two-photon absorption (2PA) phenomenon has attracted attention from various fields ranging from chemistry and biology to optics and engineering. Two of the common NLO applications in which organic materials have been used are three-dimensional (3D) fluorescence imaging and optical power limiting. Two-photon absorbing materials are, therefore, in great demand to meet the needs of emerging technologies. Organic molecules show great promise to meet this need as they can be customized through molecular engineering, and as the development of two-photon materials that suit practical application intensifies, so does research to meet this need. However, there remains some uncertainty in the …

A Socio-Economic Assessment Of Marine Turtle Eco-Tourism, Kendra Cope

Electronic Theses and Dissertations

Marine turtles have historically contributed to economic activity through consumptive harvest for food, tools, and decorative objects. Only recently have they begun to benefit humans economically through non-consumptive roles, primarily as a focal point of educational eco-tourism. In recent years, the annual number of turtle walks conducted around the Archie Carr National Wildlife Refuge (ACNWR) has risen. This expansion contributed to a statistically significant increase in attendance from 2,162 in 2001 to 3,047 participants in 2014. I examined the regional economic impacts of marine turtle eco-tourism around the ACNWR using social surveys and an economic impact analysis tool. IMPLAN, an …

Conservation Laws And Electromagnetic Interactions, Veerachart Kajorndejnukul

Electronic Theses and Dissertations

Aside from energy, light carries linear and angular momenta that can be transferred to matter. The interaction between light and matter is governed by conservation laws that can manifest themselves as mechanical effects acting on both matter and light waves. This interaction permits remote, precise, and noninvasive manipulation and sensing at microscopic levels. In this dissertation, we demonstrated for the first time a complete set of opto-mechanical effects that are based on nonconservative forces and act at the interface between dielectric media. Without structuring the light field, forward action is provided by the conventional radiation pressure while a backward movement …

Functional Identification Of Nucleus Tractus Solitarius (Nts) Barosensitive Neurons: Effect Of Chronic Intermittent Hypoxia (Cih), Jenya Kolpakova

Electronic Theses and Dissertations

Chronic Intermittent Hypoxia (CIH) is a model used to study obstructive sleep apnea (OSA). Previously, we showed that baroreflex control of heart rate (HR) (baroreflex sensitivity) is reduced in CIH rats. While afferent function and HR in response to vagal efferent stimulation are enhanced, the effect of CIH on the central components, in particular NTS, is still not completely understood. F344 rats (3-4 mo) were exposed either to CIH or room air (RA) for 35-50 days. Following CIH exposure, rats were anaesthetized with Ket/Ace. Using single-unit extracellular recording technique, we recorded NTS barosensitive neurons in response to arterial pressure (AP) …

Fostering College Student Success: An Analysis Of The Educational Outcomes Of Florida College Students Utilizing Relative Caregiver, Road-To-Independence, And Adoption Tuition Exemptions, Lauren Murray

Electronic Theses and Dissertations

This study investigated the educational outcomes of foster care youth utilizing the Road to Independence, Adopted from DCF, and Relative Caregiver tuition exemptions to pursue enrollment in Florida's state college system during the 2012-2013 academic year. An extensive literature review was conducted to examine the history of foster care, examine a contemporary portrait of the American foster care system, and the adult outcomes of former foster care. Federal and state policies impacting the population, campus support initiatives at colleges nationwide and the concept of resilience were also explored. In conjunction with the Florida Department of Education's Division of Accountability, Research …

The Interspecies Family: Attitudes And Narratives, Nicole Owens

Electronic Theses and Dissertations

Families are conceptualized and accomplished in increasingly diverse ways in the 21st century. A constructionist framework was utilized to examine a widespread contemporary family form, the interspecies family. This mixed-method approach relied on both quantitative survey data and qualitative interview data. First, survey data from the 2006 Constructing the Family Survey were analyzed to understand who in America counts pets as family. Many social demographics were associated and predicted counting pets as family but gender was one of the strongest associations. However, marital status moderated the relationship between gender and counting pets as family at a statically significant level. Men …

Translocation Of A Semiflexible Polymer Through A Nanopore, Ramesh Adhikari

Electronic Theses and Dissertations

The transport of a biomolecule through a nanopore occurs in many biological functions such as, DNA or RNA transport across nuclear pores and the translocation of proteins across the eukaryotic endoplasmic reticulum. In addition to the biological processes, it has potential applications in technology such as, drug delivery, gene therapy, and single molecule sensing. The DNA translocation through a synthetic nanopore device is considered as the basis for cheap and fast sequencing technology. Motivated by the experimental advances, many theoretical models have been developed. In this thesis, we explore the dynamics of driven translocation of a semiflexible polymer through a …

Practical Use Of Ground Penetrating Radar: A Survey Of Coastal Historic Cemeteries In Brevard County, Florida, William Boynton

Electronic Theses and Dissertations

Ground Penetrating Radar (GPR) research conducted in coastal environments is one area that is lacking in archaeology. Surveys conducted in this type of environment afford the opportunity to evaluate the practical use GPR under field conditions. Coastal environments are effective for this evaluation because they offer a host of conditions that GPR surveys do not normally encounter at one time. The relationship of the land to the coast, sub-surface conditions and reliable survey areas create a "perfect storm" to test how practical the use of GPR is in coastal environments. This research is a study of homestead cemeteries situated within …

Quantum Chemical Studies For The Engineering Of Metal Organic Materials, Hector Javier Rivera Jacquez

Electronic Theses and Dissertations

Metal Organic Materials (MOM) are composed of transition metal ions as connectors and organic ligands as linkers. MOMs have been found to have high porosity, catalytic, and optical properties. Here we study the gas adsorption, color change, and non-linear optical properties of MOMs. These properties can be predicted using theoretical methods, and the results may provide experimentalists with guidance for rational design and engineering of novel MOMs. The theory levels used include semi-empirical quantum mechanical calculations with the PM7 Hamiltonian and, Density Functional Theory (DFT) to predict the geometry and electronic structure of the ground state, and Time Dependent DFT …

The Helping Professional Wellness Discrepancy Scale (Hpwds): Development And Validation, Ashley Blount

Electronic Theses and Dissertations

Wellness is an integral component of the helping professions (Myers & Sweeney, 2005; Witmer, 1985). Specifically, wellness is included in ethical codes, suggestions for practice, and codes of conduct throughout counseling, psychology, and social work fields (see American Counseling Association Code of Ethics, 2014; American Psychological Association Ethical Principles of Psychologists and Code of Conduct, 2010; National Association of Social Workers Code of Ethics, 1996). Even so, wellness in helping professionals is a difficult construct to measure. Thus, the purpose of the research investigation was to develop the Helping Professional Wellness Discrepancy Scale (HPWDS) and examine the psychometric features of …

The Crypt People From The Cathedral Basilica Of Saints Stanislaus And Vladislaus, Vilnius, Lithuania: Reconstruction Of Life Histories Using Stable Isotope Analysis, Kaylee Schotten

Electronic Theses and Dissertations

Stable isotope analyses of multiple tissue types have been used to reconstruct life histories of individuals from past populations. This thesis presents the life history reconstructions of a unique population recovered from a 16th to 18th century cathedral crypt located in Vilnius, Lithuania. The sample consists of 23 individuals (21 males, one possible female, and one juvenile). Stable carbon, nitrogen, and oxygen isotope analyses were performed on bone and dentin collagen, and on bone and enamel hydroxyapatite, resulting in eight isotope values per individual, providing both childhood and adult dietary and migration information. For bone collagen the average δ13C isotope …

Inhibition Of Angiogenesis Associated With Ovarian Cancer By Nanoparticles Of Cerium Oxide (Cip), Sudipta Seal, Shailendra Giri, Ajay Karakoti, Viji Shridhar

UCF Patents

The invention provides a method of treating ovarian cancer in a mammal, the method inhibits angiogenesis associated with the cancer and comprises the parenteral administration to the mammal of an effective amount of cerium oxide nanoparticles having a predominance of Ce+3.

Co-Targeting Of Aurora A Kinase And Lim Kinase 1 For Cancer Therapy, Ratna Chakrabarti

UCF Patents

Despite recent advances in development of improved cancer therapeutics one of the many clinical challenges is that patients often show resistance to cancer drugs. This invention provides evidence that an alternate method of treatment of cancer could be adopted for improved efficacy of existing therapies and /or treatment of drug resistant cancers. This study describes a novel functional relationship between two proteins that regulate proliferation of cells. Because these proteins are involved in cell growth, the amounts of these proteins are tightly regulated in normal cells however in cancer cells, abnormally increased amounts of these proteins are noted. One of …

Methods And Materials For Increasing Potency Of Cells (Con 1), Kiminobu Sugaya, Angel Alvarez

UCF Patents

Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.

Melatonin And Neurogenesis: A Comparative Study Of The Efficacy Of Melatonin, Its Precursors, And L-Dopa On Neural Stem Cell Metabolism In Human Adult Neurospheres, Omar Heriba

HIM 1990-2015

Human neurosphere stem cells offer promising potential for the treatment of neurodegenerative diseases. Their well characterized multi-potency of differentiating into neurons, astrocytes, and oligodendrocytes when exposed to the optimum exogenous growth factors make them an exciting area of study (38). Finding novel endogenous methods of modulating stem cell metabolism will allow for the safer treatment of various brain disorders (34). In this experiment, melatonin, N-acetylserotonin, L-tryptophan, and L-DOPA are added in three different concentrations to neurospheres suspended in HNSC/GBM media with less than optimal concentrations of exogenous epidermal growth factor (EGF) and fibroblast growth factor (FGF). The alamarBlue assay (resazurin) …

Media Sensationalism And Its Implications On The Public Understanding Of Science, Christopher Barsoum

HIM 1990-2015

Myths, misinformation, and sensationalism. These are common enemies that directly inhibit the public understanding of science. In particular, the media is often responsible for mishandling or otherwise misrepresenting scientific information, historically and presently speaking. Many sources can combat the public understanding of science through pseudoscientific means. This includes but is not limited to religion, the media, politics, or just simple hearsay. For example, Young Earth creationism is deeply rooted in Christian theology, but the beliefs hold no scientific basis. Yet, almost half of Americans still believe in Young Earth creationism. Another such example is anti-vaccination campaigns due to fears of …

Predicting Science Literacy And Science Appreciation, Robert Hellmuth

HIM 1990-2015

Research has shown that the benefits of having a populace literate in science are great. Even if citizens are not literate in basic science, it is important that citizens still appreciate science and those with expertise in the field for many reasons. Recent research suggests that the United States (U.S.) has lower levels of science literacy than it should. Evidence may also suggest that many U.S. citizens are not appreciative of science. Overall, little research has been conducted on what may predict science literacy and science appreciation which is the aim of this research. Specifically, I have examined socio-personal variables, …

Using The Yeast Two-Hybrid System To Determine The Function Of Parkin E3 Ubiquitin Ligase, Vanessa Nguyen

HIM 1990-2015

Parkin is a cytosolic E3 ubiquitin ligase that is recruited to the mitochondria during cellular stress and has been suggested to be involved in a variety of biological processes such as mitophagy. The recruitment of Parkin (PARK2) to the mitochondria is dependent upon the kinase activity and the accumulation of PINK1 on damaged mitochondria. Mutations in either PINK1 or Parkin genes disrupt this protective pathway and lead to the accumulation of damaged mitochondria. From a clinical standpoint, mutations in the PARK2 gene have been associated with the progression and onset of autosomal recessive juvenile parkinsonism. Without the presence of a …

Madama Butterfly: The Mythology; Or How Imperialism And The Patriarchy Crushed Butterfly's Wings, Adriana Nieves

HIM 1990-2015

As a popular historic work with constant and worldwide performances, the sexist and racist narratives disseminated by Giacomo Puccini's opera Madama Butterfly causes harmful social and political ramifications. Many scholars point to this opera specifically when discussing the fetishization of Asian females, and mention the title character as the quintessential example of damaging stereotypes. Thus, I conduct a postcolonial and feminist reading of Madama Butterfly, through analysis of the opera's libretto, the libretto sources, and the opera's score. I unravel the Orientalist assumptions that make up the foundation of the Butterfly narrative, and trace them as they make their way …

Exploring The Effects Of Social Media Use On The Mental Health Of Young Adults, Amelia Strickland

HIM 1990-2015

The intent of this thesis is to explore the relationship between social media use and mental health in the young adult population. Current research indicates that there is a connection between increased social media use and deteriorated mental health. Unfortunately, young adults, the most active social media users, have a predominantly high risk for developing mental health issues, making this connection particularly concerning. At present, it is unclear how social media and mental health are connected; therefore this thesis explores the individual and social theories that may give reason for this connection. Theories that are discussed include: the impact of …

Media Influence On Risky Driving Behaviors Among Adolescents And Emerging Adults, Kelly Silberman

HIM 1990-2015

Within the last few decades there has been an abundant increase in the amount of violent video games and movies shown within the media. Many of these violent videogames and movies include reckless driving behaviors or certain car scenarios that engross the viewer into wishing to imitate the actions they see on the screen. With that being said, majority of these viewers are adolescents or emerging adults who are beginning to drive and are prone to replicating what they see as adequate driving behaviors. The intent of this thesis is to indicate whether or not the amount of risky driving …

Cohabitation: Looking Through A Keyhole, Mary Joy Torrecampo

HIM 1990-2015

Initially, my developing body of work aimed to redesign the traditions of representational painting, specifically the female nude, to depict the contemporary notions of lesbianism and femininity in an honest and empowering manner as a form of identity and not as vehicle for voyeurism. As an artist who paints the female nude and identifies as a woman and a lesbian, I examine the preexisting notions of the male gaze and the effect of socialization as it pertains to my work. The act of looking from the point of view of a woman, which is not synonymous with a "female gaze", …

Compounds That Suppress Cancer Cells And Exhibit Antitumor Activity, James Turkson, Patrick Gunning

UCF Patents

The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.

Data Documentation & Metadata, Sai Deng

Faculty Scholarship and Creative Works

No abstract provided.

Oxidase Activity Of Polymeric Coated Cerium Oxide Nanoparticles, J. Manuel Perez Figueroa, Atul Asati, Charalambos Kaittanis, Sudip Nath, Santimukul Santra

UCF Patents

methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqeous redox catalyst with enhanced activity at an acidic to moderaly alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decompostion, decontamination and inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fuorescent probe in immunoassays or other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits …

Detection Of Analytes Using Metal Nanoparticle Probes And Dynamic Light Scattering (Us), Qun Huo, Qiu Dai, Xiong Liu

UCF Patents

Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

Nanoparticles Of Cerium Oxide Targeted To An Amyloid-Beta Antigen Of Alzheimer's Disease And Associated Methods, Sudipta Seal, Annamaria Cimini, Barbara D'Angelo, Soumen Das

UCF Patents

Disclosed is a composition immunologically targeted to Alzheimer’s disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

Second Semi-Annual Program Progress Performance Report For University Transportation Systems, Florida Solar Energy Center, David L. Block

FSEC Energy Research Center®

The Electric Vehicle Transportation Center (EVTC) supports the U.S. Department of Transportation's strategic goal of planning for near-term integration of alternative fuel vehicles as a means to build a sustainable transportation system. The project will evaluate technologies, standards and policies to ensure seamless integration of electric vehicles (EVs) into a complex transportation network and electricity grid. The EVTC will bridge the gap between deployment of electric vehicles and the traditional transportation system.

The EVTC's goals were described in detail in the previous Program Progress Performance Report. These goals have not changed significantly and this report provides updates to each of …

Binary Probe System For Sensitive Detection Of Target Analytes, Dmitry Kolpashchikov, Yulia Gerasimova

UCF Patents

We suggest a novel PCR-free assay that allows fluorescent detection of specific nucleic acid sequences with high selectivity and sensitivity. The assay can discriminate signal nucleotide substitution in an analyzed nucleic acid with high accuracy even at ambient temperatures. The high sensitivity of the assay is predetermined by the possibility of fluorescent signal amplification due to the catalytic action of an enzyme, which recognizes only the complex of the probe with the analyte and not the probe itself. The assay is cost-efficient, which is especially beneficial for the analysis of multiple nucleic acid analytes: two short unmodified oligonucleotides need to …

Microarrays Of Binary Nucleic Acid Probes For Detecting Nucleic Acid Analytes (Us), Dmitry Kolpashchikov

UCF Patents

Some embodiments of the invention are directed to a microarray of binary nucleic acid probes for the detection of one or a plurality of nucleic acid analytes in a complex sample in a single high throughput assay with extraordinary specificity under physiologic conditions. Any binary nucleic acid probes that generate a detectable signal when bound to analyte are suitable for use in the microarrays, including binary deoxyribozyme or ribozyme probes; nonenzymatic binary probes for fluorescent detection, nonenzymatic binary dye-binding probes, and binary split enzyme peroxidase probes for visual detection of nucleic acids. The invention is also directed to new non …