Digital Commons Network^™

Exploring The Role Of Hes4 During Retroviral Infection, Raphael Opoku

Graduate Studies Theses and Dissertations 2026

Human immunodeficiency virus (HIV) infection disrupts immune homeostasis and impairs antiviral defenses, partly by compromising natural killer (NK) cell activity, with simian immunodeficiency virus (SIV) infection in rhesus macaques serving as a valuable model to investigate these mechanisms. This research examines the regulatory role of HES4 and its isoforms in NK cell function during retroviral infection, with particular focus on how Notch signaling–dependent regulation of HES4 shapes NK effector responses. HES4, a downstream effector of the Notch signaling pathway, encodes transcriptional repressors central to immune cell differentiation, yet its contribution to NK cell biology remains poorly understood. Using molecular and …

Magic In The Margins: A Painter's Ode To Love, Loss, And Laughter, Angelina B. Palmisano

Graduate Studies Theses and Dissertations 2026

In art, there lives a gift of transcendence with power to transport the viewer into another realm of thought and imagination beyond the limitations of our physical world. This thesis, Magic in the Margins: A Painter’s Ode to Love, Loss, and Laughter, is an exploration of the ways art can serve as both sanctuary and vessel for storytelling. Satire is used to criticize vices, and subtle humor is my tool to resonate serious content necessary for authentic self-reflection. I am investigating how to use painting as a means to make deeply intimate and visceral connections. Each canvas exploring the innermost, …

The Effects Of Episodic Facilitation And Immersion On Memory Formation During Learning Of An Exterior Preflight Inspection Procedure, Nathan A. Sonnenfeld

Graduate Studies Theses and Dissertations 2026

This research examined the use of episodic facilitation—instructional elements aligned with episodic memory (EM) processes—to affect learners’ memory of simulation training for an aviation procedure. Despite its assumed benefits in industry and theory, virtual reality (VR) has shown limited advantages over conventional media for training procedures, in part because prevailing frameworks emphasize semantic and procedural outcomes, leaving memory of training experiences as events underexamined. To address this gap, this work advances human factors research by examining EM as a design consideration, an outcome, and an explanatory mechanism for how simulation training experiences are remembered. Grounded in theories of EM and …

Watch Your Step, Mind The Crowd: Socially Compliant Navigation In Unstructured Environments, Jack Vice

Graduate Studies Theses and Dissertations 2026

Autonomous mobile robots increasingly operate in complex real-world environments characterized by uneven terrain, dynamic obstacles, and human presence. This dissertation addresses the fundamental challenge of developing adaptive navigation strategies that enable robots to safely and effectively traverse unstructured outdoor environments including construction sites, agricultural fields, and disaster areas while maintaining social compliance around people. We advance this capability through five complementary contributions that collectively target dynamic, unstructured, human-occupied environments. First, we demonstrate evolutionary optimization of legged mobility for uneven terrain. Second, we propose using a spatiotemporal autoencoder to learn the temporal dynamics of moving people and objects. Third, we introduce …

Photothermal Excitation And Optical Interferometric Readout Of Mos2 Nanomechanical Resonators, Sadia Afrin

Graduate Studies Theses and Dissertations 2026

Two-dimensional (2D) materials have emerged as promising candidates for nanoelectromechanical systems (NEMS) due to their exceptional mechanical, optical, and electrical properties. Among these materials, molybdenum disulfide (MoS2) has attracted considerable interest for nanomechanical resonator applications because of its low mass density, high mechanical strength, and semiconducting nature. This thesis presents the fabrication, theoretical modeling, and experimental characterization of suspended MoS2 drumhead resonators. The devices were fabricated by mechanically exfoliating MoS2 flakes from bulk MoS2 crystals and transferring selected flakes onto pre-patterned substrates using a dry-transfer process. Mechanical resonance was excited through photothermal actuation using a modulated blue laser, while device …

Fgf19 As A Colorectal Cancer Serum Biomarker And Fgfr4 As A Mediator Of Anti-Her2 Resistance In Breast Cancer, Jordan Beardsley

Graduate Studies Theses and Dissertations 2026

The fibroblast growth factor 19 (FGF19)-fibroblast growth factor receptor 4 (FGFR4) signaling pathway regulates hepatic metabolism, bile acid (BA) synthesis, and hepatocyte proliferation. This signaling axis also is implicated in promoting tumor progression, therapeutic resistance, and metastasis in certain cancers.

In colorectal cancer (CRC) there is a critical need for non-invasive biomarkers for disease detection and monitoring. We identified FGF19 as a candidate CRC serum marker through meta-transcriptomics and found FGF19 to be expressed and secreted by CRC cell lines. Tumor-derived FGF19 was detectable in mouse serum at levels correlating with tumor volume in a subcutaneous xenograft model. RNA sequencing …

Sensory And Emotional Impacts On Modern Consumer Experiences, Winter E. Bland

Graduate Studies Theses and Dissertations 2026

This dissertation comprises two essays examining how environmental and psychological stimuli shape consumer experience, attitudes, and cognition. The first essay investigates the joint influence of scent temperature (warm versus cool) and scent arousal (stimulating versus relaxing) on experiential attitudes and cognitive performance in digitally mediated consumption environments. Across multiple lab experiments with biometric validation, findings reveal that these two scent dimensions interact to shape downstream outcomes. Warm, low-arousal scents (e.g., vanilla) enhance consumers' experiential evaluations of digital interactions but do not improve task performance, whereas cool, high-arousal scents (e.g., peppermint) boost cognitive efficiency and accuracy but do not elevate experiential …

Vaccine Hesitancy In Arabic Discourse: A Multi-Method Social Media Study, Nada Dimashkieh Chehab

Graduate Studies Theses and Dissertations 2026

Vaccine hesitancy — the state of uncertainty about vaccination — poses global public health challenges, undermining efforts to prevent infectious diseases. It is also a contextual phenomenon, shaped by social and political forces. While survey-based research on vaccine hesitancy is abundant both globally and in the Arab world, humanities-oriented approaches using discourse analysis remain limited especially in Arabic on social media: some have tracked trends on Twitter, but virtually none have done so on Facebook. This dissertation addresses these gaps through a multimethod design combining Textual and Trend Analyses and Critical Discourse Study. It examines vaccine-related trends and discourses among …

Pioglitazone Uncouples Macrophage Inflammatory Signaling From Epithelial Oxidative Stress During Map Infection Mimicking Crohn’S Disease Treatment, Sabera Akter Bushra

Graduate Studies Theses and Dissertations 2026

Crohn’s disease (CD) is a chronic inflammatory bowel disease characterized by intestinal inflammation, epithelial barrier dysfunction, and abnormal immune signaling. CD pathophysiology is increasingly linked to Mycobacterium avium subspecies paratuberculosis (MAP) infection, which increases chronic macrophage activation and the production of inflammatory mediators that lead to epithelial damage. Among these mediators, CXCL10, TNF-α, and IL-6 contribute in inflammation, while NOX-1 and SERPINE-1 indicate epithelial oxidative stress and damage. Despite the role of macrophage-epithelial interaction in CD, selective pharmaceutical regulation of this axis remains unclear. Pioglitazone, an FDA-approved PPARγ agonist used for type 2 diabetes, is an appealing repurposing candidate, given …

Non-Gaussian Phenomena In Light Scattering And Applications, Shubham Atul Dawda

Graduate Studies Theses and Dissertations 2026

Physical reality is rarely deterministic; which, when probed by electromagnetic fields that also fluctuate, leads to observables that are most efficiently modelled as statistical processes. At equilibrium, this is usually achieved by invoking the Gaussian statistics of underlying physical processes, however, in practice, one often encounters out-of-equilibrium conditions where Gaussian descriptions may not suffice. Such situations are plentiful in nature– from biology to astronomy. This dissertation addresses several non-Gaussian phenomena associated with light scattering, and includes specific models’ derivations, experimental techniques developments, and demonstrations of potential applications. The systematic presentation will consider circumstances that infringe upon specific assumptions of the …

Ex Vivo Sensitivity Assays With Molecular Validation To Guide Preclinical Drug Selection For Schwann Cell Tumors, Ethan W. Hass

Graduate Studies Theses and Dissertations 2026

Schwann cells are the glial cell of the peripheral nervous system. They are dependent on receptor tyrosine kinase-mediated RAS signaling, cell matrix adhesion, and cell-cell contact to proliferate during nerve development and repair. These pathways become deregulated with loss of function of the merlin tumor suppressor encoded by NF2, leading to benign tumors called schwannomas. Patients with NF2-related schwannomatosis (NF2-SWN) develop bilateral vestibular schwannomas that cause hearing loss, tinnitus, and death from brainstem compression if untreated. Severe NF2-SWN causes multiple spinal and peripheral schwannomas and neuropathic pain. Schwannomas require careful monitoring, trial and error use of repurposed anti-cancer …

The Influence Of Limb Dominance On Neural Activation Patterns While Performing Different Motor Control Tasks, Kevin A. Hooks

Graduate Studies Theses and Dissertations 2026

Humans interact with our environment in many ways. One of the most outward-facing aspects of this is limb dominance. The neural underpinnings of limb dominance remain in question today. The objective of this research was to use different methods to analyze neural activation while subjects performed upper extremity motor tasks while recording electroencephalography (EEG). The first experiment used decoding methods to examine whether neural signals collected from the contralateral limb could be used to train a classifier to test on the ipsilateral limb during a reach-to-grasp or reach-to-touch task. It was determined above chance level that within-subject action and direction …

Integrated Optical Probes For Confocal Scanning Imaging And Adjustable Coherent-Gated Dynamic Sensing, Yonglin Huang

Graduate Studies Theses and Dissertations 2026

Optics and photonics have been one of the most important sciences and technologies that impact modern human life in a big way. For example, fiber-optics for communications and artificial intelligence. Optical probes are critical components for optical imaging and optical sensing technologies that have been actively researched and developed in the past decades. Advanced fiber-optic sensor probes with smaller size, better performance, lower noise, higher photon efficiency, rapid sensing time, and lower cost are needed in many applications, such as nanoscale material science, chemistry, and biomedical fields, etc.  In this project, new fiber-optic sensor probe technologies and integrated micro-optic devices …

Investigating The Anti-Apoptotic Properties Of The N-Terminus Of The Chlamydia Trachomatis Effector Tarp, Kasey S. Jordan

Graduate Studies Theses and Dissertations 2026

As the most prevalent bacterial STI in the United States and leading cause of infection-related blindness worldwide, the obligate intracellular bacteria, Chlamydia trachomatis (Ct), poses a significant threat to public health. As an obligate intracellular bacteria, invasion of the host cell is a crucial step in Chlamydia’s developmental cycle. To drive invasion, Ct injects prepackaged effectors into the host cell using a T3SS. An early Chlamydial effector, translocated actin recruiting phosphoprotein, or Tarp, interacts with host cell actin to promote invasion, mediated via Tarp’s C-terminal region. Although the function of Tarp’s C-terminus is well defined, the Tarp’s N-terminus …

High School Teachers' Perceptions And Experiences Of Legislative Changes: An Interpretative Phenomenological Analysis, Marie Lewis

Graduate Studies Theses and Dissertations 2026

The purpose of this interpretative phenomenological analysis was to explore the perceptions and experiences of high school English Language Arts teachers in one public school district in the state of Florida as they navigated educational legislation that has been implemented over the last five years. The study interviewed ten experienced high school ELA teachers who had taught for more than five years in Florida’s public school system. One semi-structured interview was conducted along with brief follow-ups to share thematic statements with the participants. This study also included a document analysis of HB 1467 and HB 1069 as well as the …

Development Of The Simultaneous Alcohol And Cannabis Use Expectancy Questionnaire (Sac-Eq), Shane D. Marohnic

Graduate Studies Theses and Dissertations 2026

Background: Simultaneous alcohol and cannabis use (SAC/SAM), defined as using alcohol and cannabis at the same time so that their effects overlap, has been identified as a hazardous form of polysubstance use. Expectancies are a causal mechanism and can be changed with predictable reductions in substance use and associated consequences, yet only one measure has been developed to assess expectancies related to SAC. Due to limitations of the existing measure, this study sought to create a more comprehensive SAC expectancy scale. Method: Three phases of participants (Phase 1, N = 493; Phase 2, n = 4; Phase 3, n …

Mathematical Modeling And Characterization Of A Variable Stiffness Ankle-Foot-Orthosis, David E.L. Richards

Graduate Studies Theses and Dissertations 2026

Conventional ankle–foot orthoses (AFOs) typically employ static stiffness profiles that do not replicate the dynamic quasi-stiffness of the human ankle during gait. Variable stiffness mechanisms (VSMs) offer a promising alternative solution for gait pathologies, such as foot drop and post-stroke hemiparesis; however, their implementation is limited by the lack of accurate mathematical models capable of predicting force and stiffness characteristics. The objective of this thesis is to develop and validate comprehensive mathematical models describing the kinematics and kinetics of a novel variable stiffness ankle–foot orthosis (VS-AFO). This study derives governing equations to characterize how mechanical adjustments influence the force transmission …

Soil Texture And Organic Matter Influence Hydraulic Performance Of Stormwater Infiltration Systems Across Antecedent Moisture Conditions, Laura E. Andrade Barron

Graduate Studies Theses and Dissertations 2026

Stormwater infiltration systems are widely used to improve urban stormwater management by promoting drainage and groundwater recharge while treating nonpoint source pollution such as nutrients in surface runoff. Nutrient removal and hydrologic performance of these systems are closely coupled and both are dependent on characteristics of underlying soils. In this study, laboratory flow-through experiments were conducted using 30 intact cores taken from six soil types with different textures (0.99-16.63% clay content) and organic matter contents (OMC 0.44-93.3%). Measured cumulative fluxes from laboratory experiments were used to calibrate numerical models simulating flow through porous media (HYDRUS-1D). Calibrated models were used to …

Detecting Error In Ai-Generated Text: The Effects Of Authorship And Word Presentation Speed, Gabriela Flores Cruz

Graduate Studies Theses and Dissertations 2026

The increased us of artificial intelligent (AI) chatbots powered by Generative Pre-trained Transformers has raised concerns about users’ ability to detect errors of AI-generated text. This dissertation examined how readers identify inconsistencies in AI-generated expository passages using the inconsistency detection paradigm from comprehension monitoring research. Across two experiments, it investigated whether perceived authorship and word presentation speed influenced inconsistency detection. Experiment 1 used a 3 (author: human, AI, no author) × 2 (inconsistency type: internal, external) between-subjects design. Perceived authorship did not significantly affect hit rates, sensitivity, or response bias. Exploratory analyses indicated that reading comprehension and working memory predicted …

Homoplasy Of Maxillary Orthognathism In Derived Homo, Jared Jordan

Graduate Studies Theses and Dissertations 2026

The evolution of the orthognathic condition in the genus Homo represents a monumental transition toward the facial morphology of modern humans from that of earlier hominins, but the phylogenetic positioning of this transformation remains poorly understood. This study investigated temporal trends in maxillary and mandibular prognathism in the genus Homo, and whether maxillary and mandibular shortening in East Asian H. erectus and later East Asian Middle Pleistocene Homo (e.g., Homo longi) represent independent derivations of orthognathic morphology, thereby making orthognathism a homoplasy in the genus Homo. Using a sample of roughly 109 cranial and mandibular specimens spanning …

Passenger Pigeons, Dodos, Neanderthals, Jordan Alexander

Graduate Studies Theses and Dissertations 2026

Passenger Pigeons, Dodos, Neanderthals is a short story collection rooted in Afrofuturism and Southern literature. Passenger Pigeons centers the experiences of queer Black American women in various settings, from Mars to rural Florida. The title story of the collection follows Teri, a human on Mars, attempting to integrate into a society of Martians who exoticize and tokenize her. In this story, I use science fiction as a vehicle to confront the microaggressions and overt racism people of color often experience in professional environments. “Rather Be the Devil,” is a fabulist story detailing the character Man’s journey to find his missing …

Computational Modeling Of Bubble Dispersion In Alginate Hydrogel Foams For Radiologically Equivalent Biomedical Phantoms, Godson N. Brako

Graduate Studies Theses and Dissertations 2026

The foaming of hydrogels presents a promising strategy for tailoring mechanical and radiological properties to replicate biological soft tissues for biomedical phantoms. Achieving uniform and predictable void fraction distributions in alginate hydrogel foams remains a challenge due to the complex interplay between bubble dynamics, matrix rheology, and interfacial forces during the pre-gelation aeration stage. This thesis develops a Computational Fluid Dynamics framework using the transient Eulerian two-fluid approach to predict void fraction distribution in alginate hydrogel precursor solutions aerated by air injection through a bottom nozzle. The objective is to use the framework for design of the foaming system to …

Multi-Scale Drivers Of Beetle Biodiversity In A Rapidly Urbanizing Region, Alessandra Pandolfi

Graduate Studies Theses and Dissertations 2026

As cities continue to expand, designing urban landscapes that balance ecological resilience with biodiversity conservation has emerged as a pressing challenge. This dissertation examines urban ecosystems as complex and dynamic environments shaping plant and animal communities, with a particular focus on ground-dwelling beetles as ecologically significant indicators of environmental change. Conducted across the Orlando metropolitan area, one of the fastest-growing regions in the United States, this dissertation integrates experimental and observational approaches. Specifically, it aims to (1) test sustainable landscaping practices, (2) compare the ecological outcomes of conventional and alternative residential landscape designs, and (3) assess how gradients of urbanization …

“I Call For The Resurgence And Reclamation Of Our Indigenous Ways”: Institutional Landscapes, Resistance, And The Experiences Of Mmir Advocates, Sara Tehrani

Graduate Studies Theses and Dissertations 2026

Indigenous Peoples across Turtle Island experience disproportionately high rates of violence and homicide compared to other racial groups. Rooted in coloniality and sustained by Western institutions, this epidemic is recognized as the Missing and Murdered Indigenous Relatives (MMIR) crisis. In response, Indigenous women have mobilized the MMIR Movement to raise awareness and advocate for institutional change. Although scholarship on MMIR has expanded, limited research has explored the experiences of MMIR advocates. This study interrogates the institutional landscapes that shape MMIR advocacy and explores the resistance strategies advocates employ to address the crisis. Using reflexive thematic analysis, this study examines semi-structured …

Examining Attrition In Rtms For Smoking Cessation: The Roles Of Perceived Research Burden And Delay Discounting, Miranda Proctor

Graduate Studies Theses and Dissertations 2026

This secondary analysis examined predictors of attrition in a randomized clinical trial conducted by Roswell Park Comprehensive Cancer Center evaluating repetitive transcranial magnetic stimulation (rTMS) for cigarette smoking cessation. Smoking cessation reduces cancer risk and mortality and improves mental health outcomes. Although rTMS shows promise for supporting sustained abstinence by targeting neurobiological mechanisms underlying nicotine dependence, participant attrition threatens statistical validity, reduces power, and limits generalizability. Identifying predictors of attrition is therefore critical for optimizing trial design and retention.

Research examining predictors of attrition in smoking cessation trials remains limited. Prior work in other clinical populations suggests that higher perceived …

A Sensory Ecology Of Fear: Moonlight-Mediated Predation Risk And Foraging Behavior In Neotropical Electric Fish, Chiu Lok Poon

Graduate Studies Theses and Dissertations 2026

Animals must forage to acquire energy for survival and reproduction, yet foraging exposes them to predators. This creates a trade-off between energy intake and safety, wherein the perception of predation risk alone can alter activity patterns. Within this trade-off, risk, energetic needs, and sensory adaptations vary, shifting the balance and favoring different foraging strategies. Using Neotropical electric fish as a study system, I investigated how foraging under predation risk is shaped across biological scales, including environmental dynamics, interspecific sensory differences, activity-timing mechanisms, and intraspecific variations. These nocturnal fish emit continuous electric signals to sense their environment, allowing non-invasive monitoring of …

Computational Methods For Rna 3d Structure Classification And Structural Motif Discovery, Nabila Shahnaz Khan

Graduate Studies Theses and Dissertations 2026

Non-coding RNAs perform diverse and essential cellular functions, and the study of RNA structures is expanding rapidly. The growing volume of RNA 3D structures highlights the need for efficient computational methods to identify recurring structural motifs, which are often conserved and critical to RNA function. However, the complexity and redundancy of RNA structures in existing databases pose significant challenges for motif discovery and structural analysis. To address these challenges, this dissertation presents three complementary computational approaches. First, a non-redundant RNA structural dataset, RNA-NRD, was developed to systematically reduce redundancy in RNA structural data and provide a reliable foundation for downstream …

Revolution In The Age Of Social Media: A Mathematical Model For Information, Dissent, And Stability, Killian Muollo

Graduate Studies Theses and Dissertations 2026

Revolutions, defined by Skocpol as rapid transformations in class, state, and/or social structures, are important world events that can cause civil wars, spark international trends, and result in transitions toward democratic and autocratic regimes alike. They are characterized largely by the mechanism of mass mobilization, which is increasingly facilitated by online networks and digital communication. In this dissertation, we investigate such means and outcomes of revolutions as dynamical systems. We construct three models describing separate but complementary aspects of revolution, beginning at the smallest unit of analysis and then moving outward in scope. First, we construct a graph-based model to …

Hunter. Hunted. Human: Warfighters' Emotional Responses To Weapons In Tactical & Strategic Context, Simon Mace

Graduate Studies Theses and Dissertations 2026

Human emotional responses to weapons have long been assumed to be relatively parsimonious, comprised predominately of aggression, anxiety, and fear responses. However, most research on this weapons effect has focused on civilians – who are notably more likely to be targeted by than to employ weapons. So, there is reason to speculate that emotional responses to weapons vary more than previously believed. This is significant for three reasons. First, positive emotional responses generate more desirable combat behaviors, specifically the willingness to engage adversaries. Second, negative emotional responses catalyze an unpredictable range of behaviors, many of which are tactically and operationally …

Meeting Accreditation On A Deadline: Using Generative Ai To Rapidly Develop A Graduate Course, Cory Knill, Sean Devan

Teaching Repository of AI-Infused Learning

This entry details an "expert-in-the-loop" framework for rapidly developing an accredited, graduate-level Health Physics course under significant time constraints. The strategy utilized Large Language Models to generate foundational course materials including the syllabus, lecture outlines, and in-class simulations, which were then rigorously curated by faculty. This human-AI collaborative approach enhanced efficiency, enabling instructors to focus more on high-impact, active learning experiences for students.