Digital Commons Network^™

Evaluating Novel Targeted Combination Therapies For Gastrointestinal Cancers, Joseph A. Goode

Graduate Studies Theses and Dissertations 2026

Gastrointestinal (GI) cancers remain among the leading causes of cancer-related mortality worldwide, with therapeutic resistance continuing to limit the effectiveness of current treatments. Three complementary studies were conducted to identify therapeutic vulnerabilities and evaluate novel combination strategies in pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC).  First, dual inhibition of fibroblast growth factor receptor 4 (FGFR4) and phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling was investigated in PDAC models. A combination of targeted drug treatments reduced viability, clonogenic survival, migration, and suppressed signaling pathways involved in translational control. This supported a functional interaction between FGFR4 and PI3K-mTOR co-activation in …

Visual Cues Of Human-Likeness, Not Salience, Impact Trust-Related Human-Computer Interaction, Jordan Schotz

Graduate Studies Theses and Dissertations 2026

As interactions with digital agents become increasingly integrated into daily life, understanding how visual representations influence social decision-making is critical. Previous research in human-computer interaction has frequently confounded the psychological effects of an agent's perceived human-likeness with the underlying visual salience of the stimuli. To address these persistent gaps, the present study systematically isolated the effects of human-likeness and visual cue trustworthiness on trust behavior while controlling for objective image properties. The present study expanded on and normed the Virtual Avatar Facial Stimuli Set (VAFSS), a comprehensive database comprising hundreds of identity-matched photographs and computer-generated avatars varying across a spectrum …

Unmasking Pentastomes: Generating Genomic Resources For Enigmatic Parasites, Stephanie Lyn Villella

Graduate Studies Theses and Dissertations 2026

The introduction of invasive species can disrupt ecosystems not only through competition and predation but also by introducing novel pathogens to naïve host populations. In the southeastern United States, the invasive Burmese python (Python bivittatus) has been implicated in the introduction of the pentastome parasite Raillietiella orientalis, which has been associated with increased parasite burdens and mortality in native snakes. Despite their ecological significance and ancient evolutionary history, pentastomes remain poorly represented in genomic databases, limiting efforts to understand their evolutionary origins, host–parasite interactions, and mechanisms underlying parasite emergence. This study addresses these gaps by generating the …

Site Use And Demographic Changes In A Northwest Atlantic Sea Turtle Foraging Ground, Ryan C. Welsh

Graduate Studies Theses and Dissertations 2026

and site fidelity, making mortality difficult to distinguish from redistribution. We developed a behaviorally explicit framework to separate true mortality from changes in availability caused by movement and redistribution. We evaluated this problem for juvenile green turtles (Chelonia mydas) and loggerhead turtles (Caretta caretta) captured at the St. Lucie Nuclear Power Plant intake canal on Florida’s Atlantic coast using a multi-decade capture–mark–recapture record spanning 1977 - 2023. Hidden Markov Models classified individuals into latent habitat-use strategies (Nomadic, Resident, and Transient) based on capture timing and body size. Across both species, these strategies captured consistent differences in site fidelity and recapture …

Ecological And Evolutionary Responses To Environmental Change In Two Large North American Mammals, George Zaragoza

Graduate Studies Theses and Dissertations 2026

Climate change and urbanization are resulting in rapid shifts in ecosystems. The effects of these changes are complex, and understanding how species respond is critical for predicting their impacts on genetic diversity and evolution, as well as changes in habitat suitability. Species can respond to these changes in two major ways: through behavioral or genetic adaptation, or by moving to more suitable habitat as conditions change. Adaptive genetic change, in particular, can support behavioral and physiological responses that enable species to persist in novel or changing environments, and understanding these changes can help predict how species will respond to anthropogenic …

Reliability Of Professor Ratings, Tridung Bui, Naomi Waddell, Diego Quinones, Kiran Pittan, Fabricio Escrich

High Impact Practices Student Showcase Spring 2026

No abstract provided.

Helping The Whole Heart, Aashna A. Shah

High Impact Practices Student Showcase Spring 2026

My service-learning project, “Helping the Whole Heart,” focuses on my second semester volunteering with Shepherd’s Hope, a nonprofit organization that provides free healthcare to uninsured and underinsured adults in Central Florida. The purpose of my project was to support the clinic while learning more about healthcare access, service, and community responsibility. During my shifts, I helped greet patients, check them in, prepare charts, organize paperwork, and assist the clinic team wherever I was needed. Through this experience, I learned that healthcare is about more than just medical treatment. It is also about patience, communication, compassion, and making patients feel respected. …

Tracing Evolution Through Teeth: Dental Morphology Of The Lagoa Santa Fossil Population, Kelsey Aaron

High Impact Practices Student Showcase Spring 2026

This study examines dental morphological variation among early South American populations, focusing on individuals from the Lagoa Santa region and coastal shellmound (sambaqui) populations in Brazil. Dental nonmetric traits were recorded using the Arizona State University Dental Anthropology System (ASUDAS), a standardized method for assessing crown and root morphology across populations (Qaqa et al., 2026). These traits are highly heritable and largely unaffected by environmental pressures, making them valuable for reconstructing population history, gene flow, and ancestry (Tinoco et al., 2016). Comparative analysis incorporates global dental variation and reference patterns associated with archaic hominins, including Neanderthals. Traits such as increased …

Drained Defenses: How Altered Hydrology Influences Invasive Plant Species Richness In Cypress Domes, Jamie M. Snider, Cori Mcwilliams, Natalia Knapp-Seale, Deborah Faerman

High Impact Practices Student Showcase Spring 2026

Cypress domes are unique wetland ecosystems distinct in species biodiversity and hydrologic patterns which have become increasingly degraded from alteration of hydrology. These changes are made with little understanding about how this may affect plant communities and weaken a wetland’s resistance to invasive species, shifting its plant regimes. This study investigates how altered hydrology affects the presence of invasive species and may cause plant communities to shift by studying two cypress domes on UCF campus. Three 30 meter transects were established per wetland in random cardinal directions, with 70 cm quadrats placed every 6 meters for a total of 18 …

Effects Of Kratom Mixture On Cell Death In Cos-7 Cells Using Immunofluorescence, Hoa A. Nguyen

High Impact Practices Student Showcase Spring 2026

The purpose of this project was to visualize the cellular impact of Kratom (Mitragyna speciosa), a supplement commonly utilized for pain management and opioid withdrawal. The project investigated the effects of a 5% Kratom mixture on COS-7 monkey kidney cells. By using immunofluorescence, the cytoskeleton could be observed, and we can determine if Kratom could result in cellular failure.

In the immunofluorescence protocol, the cells were fixed in a methanol based solution to preserve position, while also permeabilizing the membranes with Triton X-100, and applying specific fluorophores. We used indirect staining for Tubulin (Red, Goat anti-mouse 568), direct staining for …

How Do The Interrogation Strategies Of Women Detectives Differ In Style And Efficacy From Their Male Counterparts?, Sarah M. Quinones

High Impact Practices Student Showcase Spring 2026

This research proposal seeks to examine recorded interrogation footage and in-depth interviews of professional interrogators to analyze how their interrogation styles and efficacies differ between men and women. There is an imminent need for a reformed, standardized, and research-backed interrogation system to improve the efficacy and discriminatory habits of the justice system. The proposed hypotheses include:

• Transformational interrogation styles yield more cooperative and informative responses than transactional interrogation styles. 

• Because women’s interrogation styles more often align with transformational leadership patterns, their interrogations exhibit higher efficacies.

These hypotheses were drawn following an extensive literature review of the current academic contributions, both …

Variability In Parainfluenza Virus Derived From Persistently Infected Lung Epithelial Cells, Cassidy R. Conte

Honors Undergraduate Theses

An acute infection (AI) with RNA virus can progress to a persistent infection (PI) where infected cells continue to grow and replicate while producing progeny virions. PIs with respiratory viruses are clinically important, as they can lead to prolonged shedding of viruses and generation of mutant viruses that are altered in pathogenesis and/or immune responses. Parainfluenza type 5 (PIV5) is a prototypic RNA virus shown to cause PIs in cell culture. Plaques in tissue culture from an acute infection with parental PIV5 were homogeneous in size and shape. By contrast, plaques from PIV5 persistently infected cells were heterogeneous, having a …

Differing Circulating Microrna Profiles Of Long-Lived Polish Populations, Fabrizzio Lijeron-Herrera

Honors Undergraduate Theses

Exceptional longevity, defined as a lower biological age relative to chronological age and maintenance of functional capacity or a slowing of functional decline, is a phenotype most readily observed in centenarians and nonagenarians. These individuals exhibit a phenomenon known as compressed morbidity, spending substantially less time in poor health compared to younger elderly populations, thus representing a unique human model of delayed aging. Circulating microRNAs (miRNAs), potent post-transcriptional regulators of molecular pathways, have emerged as important modulators of aging-related pathways; however, no study has comprehensively profiled miRNAs from serum in long-lived individuals from Central Europe. In particular, Polish populations present …

The Adjustment Of Autistic First-Generation Students To Higher Education, Paris J. Cumba

Honors Undergraduate Theses

The purpose of the current study is to investigate how first-generation students on the autism spectrum adjust to higher education compared to their continuing generation and neurotypical peers through the lens of intersectionality. Previous research has studied how first-generation students and autistic students transition into college environments, but little research has explored how these identities intersect and affect college adjustment.

For this study, 189 undergraduate students completed a survey that measured different dimensions of college adjustment, such as academic motivation, self-efficacy, and current life satisfaction. ANOVA tests showed that there was no significant interaction between first-generation status and autism status …

Carbaryl Exposure Alters Gut Microbiome Composition Without Affecting Morphometrics In Eastern Purple Martin (Progne Subis Subis) Nestlings, Stephanie A. Gaspar

Graduate Studies Theses and Dissertations 2026

Eastern purple martins (Progne subis subis) rely entirely on human-provided nesting structures throughout their breeding range in eastern North America. To control haematophagous mites that commonly infest these nests, many landlords apply the carbamate insecticide, carbaryl. Although effective at reducing ectoparasite populations, carbaryl exposure may have unintended effects on the gut microbiome, growth, and condition of developing birds. This study examined the effects of carbaryl exposure on gut microbial communities and morphometric condition in wild nestlings. Nests were experimentally treated with carbaryl, and nestling morphometrics and fecal microbiomes were compared between treated and untreated groups at 18 days …

I, Cock-A-Doodle-Do: Reclaiming Masculinity Through Queer Joy And Humorous Self-Exploration, Nelson J. Garcia

Graduate Studies Theses and Dissertations 2026

I examine the contemporary norms of masculinity. My research wrestles with ultimately unresolvable stereotypes and imagery influencing current masculine behavior. I unearth queer potential through the physicality and behavior of the stereotypical “man’s man”. I infuse my own queer identity into my studio practice with an emphasis on humor and joy to subvert traditional models of male performance. This process drives self-exploration that allows me to personally respond, react, be directed, and redirected by the interactions between queerness and masculinity. Masculine and queer representations across various media, such as film, music, and television, historically and continuously inform restrictive cultural norms. …

Governing Harm: Three Essays On Anti-Lgbtq+ Legislation In The United States, Kathryn Hickey

Graduate Studies Theses and Dissertations 2026

In the United States, over 140 state bills were passed between 2014 and 2024 that directly targeted the lives of LGBTQ+ individuals. Drawing on administrative evil and the minority stress model, this dissertation demonstrates how policy environments that normalize discrimination through the passage of anti-LGBTQ+ legislation can lead to devastating consequences. Using a three-essay format, the first study conducts a qualitative content analysis of state level anti-LGBTQ+ laws passed between 2015 and 2024 to identify how administrative evil is woven into the language of the legislation. The results of this analysis show these laws systematically dehumanize LGBTQ+ individuals, restrict their …

Reliability Of Staged Maximal Aerobic Capacity Protocol Using A Combined Upper- And Lower-Body Air-Braked Ergometer, Jack J. Livingston

Graduate Studies Theses and Dissertations 2026

Maximal oxygen uptake (VO₂max) is widely recognized as the preeminent measure of aerobic capacity and is typically assessed using graded exercise testing (GXT). This study examined the test–retest reliability of VO₂peak and associated physiological responses during a staged GXT performed on a combined upper- and lower-body air-braked ergometer. Fifteen recreationally active adults (9 males, 6 females; age: 26.9 ± 7.2 years; body mass: 75.1 ± 11.0 kg) completed one familiarization session and two trials separated by ≥72 hours. Participants performed a staged GXT (40 RPM start, +3 RPM every 3 min to exhaustion) on a combined upper- and lower-body air-braked …

Behavioral Economic Factors Implicated In Young Adult Drinking In The Natural Environment: An Ema Study, Tatiana Magri

Graduate Studies Theses and Dissertations 2026

Background: Young adult (YA) alcohol use remains a prominent public health concern. Despite research efforts aimed at mitigating harms related to drinking, rates of alcohol use and adverse outcomes related to use, remain high among YAs. Previous research has identified alcohol demand, craving, and delay discounting as risk factors for problematic drinking among YAs. However, few studies have concurrently examined these constructs using methodologies that maximize ecological and contextual validity. Method: YA individuals (N=104) completed an ecological momentary assessment (EMA) protocol assessing three demand indices (i.e., intensity, Omax, and breakpoint), delay discounting, craving, and alcohol use and problems. Participants received …

Teaching Students To Prompt Ai For Understanding: Evidence-Based Strategies From A Calculus Course, Jared Campbell, Joo Young Park Ph.D

Teaching & Learning with AI

No abstract provided.

The Importance Of The Proline Residue In The Ldiapa Motif Of Cholera Toxin, Akash Bharathan

Honors Undergraduate Theses

Cholera is currently on its seventh global pandemic, disproportionately affecting developing countries. Vibrio cholerae, the bacterial etiologic agent, is able to cause infection by adhering to intestinal epithelial cells and secreting cholera toxin (CT), an AB-type exotoxin that dysregulates signaling pathways. Previous research by the Teter lab has shown that Hsp90, a host cytosolic chaperone, is required for CT to enter the cytosol where it produces toxic effects. Hsp90 binds to CT at two specific motifs, RPPDEI and LDIAPA. The prolines in the RPPDEI motif are essential for binding, but the proline in the LDIAPA has yet to be …

Understanding The Potential Biogeochemical Effects Of Alternative Restoration Materials: A Study Of Basalt And Other Materials, Cadie L. Barnes

Graduate Studies Theses and Dissertations 2026

Concern over the effects of microplastics on estuarine ecosystems and public health has prompted many restoration practitioners to switch from plastic materials to more “natural” substrates. These natural (BESE-biopolymer, cement-jute structures) and non-plastic (basalt fiber) materials should not contain harmful substances; however, their chemical composition is unknown. Natural materials may degrade faster in subtropical environments and release nutrients into surrounding waters, which is concerning for eutrophic restoration areas. Basalt fiber bags, made from melted basalt rock spun into fibers, have not been evaluated for biogeochemical impacts within estuaries. To address this knowledge gap, two field experiments and two laboratory experiments …

Reclaiming The Self: A Visual Narrative Of A Process Of Individuation Through Artistic Practice, Stacie Becker

Graduate Studies Theses and Dissertations 2026

Reclaiming the Self: A Visual Narrative of a Process of Individuation Through Artistic Practice features a multidisciplinary practice that uses visual narrative, metaphor, and symbolism to reconcile the complex intersections of internal and external identity-shaping experiences, informed by lived experience as a woman. Working across painting, mixed media, printmaking, book arts, sculpture, and restorative medical tattooing, the artist dissects the tension between internal identity and external expectations, addressing themes of gender roles, relationships, trauma, and agency. Various artistic methods serve not only as a process but also as a parallel for reclaiming, healing, and restoring an authentic, unashamed sense of …

Establishing And Testing Experiential Critical Theory (Ect), Dolores M. Batten Mrs.

Graduate Studies Theses and Dissertations 2026

There is a current gap in academia which has been largely overlooked in both pedagogy and assessment: the value of personal experience as key evidence of interpretation and meaning-making correlation. Aside from narrative writing, most current methods of literary analysis writing do not place a high value on personal experience beyond the inclusion of brief anecdotes. Yet experience is the major pathway by which an individual forms their worldview, which then informs the ways in which they interpret the world—and by extension, text. This dissertation both establishes and examines the use of Experiential Critical Theory (ECT) in pedagogical application for …

'But George Floyd Wasn't A Saint': A Critical Discourse Analysis Pre And Post George Floyd, Raya Berkley-Jacobs

Graduate Studies Theses and Dissertations 2026

May 25, 2020, George Floyd died at the hands of former police officer Derek Chauvin after he placed his knee on George Floyd’s neck for 8 minutes and 46 seconds. His death sparked outrage, protests, and calls for accountability, justice, and reform. This study addresses the impact of George Floyd’s death as a focusing event that created a policy window under which federal legislation was introduced as a response to his death. Drawing on Punctuated Equilibrium Theory and Social Construction Theory, the study utilizes a critical discourse analysis to test how the death of George Floyd impacted the amount and …

A Reconstruction Method For The Anisotropic Electrical Conductivity In A Hybrid Planar Inverse Problem, Athanasios Dimitriadis

Graduate Studies Theses and Dissertations 2026

Some single-physics medical imaging methods fail to reliably discriminate benign from malignant biological tissue. In partial response, a new class of inverse problems employ multi-physics phenomena, coupling methods of high resolution with methods of high contrast. In this thesis we are concerned with one such problem in which an anisotropic electrical conductivity is to be recovered from some internal knowledge of the current density field generated by maintaining a fixed boundary voltage. This internal data is obtained by the method of Current Density Impedance Imaging (CDII), which combines Maxwell's equations with Magnetic Resonance Imaging (MRI) measurements. The anisotropy class is …

Reflection In Still Waters: Generative Ai's Production Of Language, Jonathan D. Hawks

Graduate Studies Theses and Dissertations 2026

Language is a conceptual process of meaning-making as well as a social construction as defined by Saussure, Bakhtin, and Lacan. Large Language Models (LLMs) engage with neither process and instead present language as a finished and consumable product which undermines its fundamental aspects. The difference between representing language through probability and its structural components instead of its more inherent qualities is not a pointless distinction. This paper utilizes Narcissus as a central metaphor to show how people misread the outputs of LLMs as language which imparts to those reflected words meaning on par with our own conceptualizations of reality. People …

Benchmarking And Advancing Heterogeneous Data Reasoning With Large Language Models, Yebowen Hu

Graduate Studies Theses and Dissertations 2026

Large language models (LLMs) increasingly face complex real-world tasks requiring complex reasoning over heterogeneous inputs, including text, numbers, and structured data. This dissertation first investigates the capability boundaries of LLMs under such scenarios. Through the MeetingBank and SportsMetrics benchmarks, we show that while LLMs exhibit linguistic fluency, they struggle with factual accuracy, information density, and quantitative cross-referencing in meeting summarization and sports analysis. Using DecipherPref, a pair-wise evaluation framework grounded in the Bradley-Terry-Luce model, we further probe LLMs' inherent preferences for information-rich and lengthy inputs, and we identify critical deficiencies in financial decision-making through DeFine, where models lack precise insight …

Viral Dynamics Across Managed And Wild Pollinators: Integrating Immunity, Ecology, And Community Structure, Allison Malay

Graduate Studies Theses and Dissertations 2026

Managed honey bees (Apis mellifera) are critical agricultural pollinators, yet colonies continue to experience persistently high losses across North America and Europe. These declines are driven by interacting stressors, including parasites, pathogens, nutrition, and landscape context. Viral pathogens are key contributors to colony morbidity and mortality, but the processes governing variation in viral prevalence, load, and host response remain incompletely understood. This dissertation investigates how viral dynamics in honey bees emerge from interactions among host immunity, colony condition, environmental context, and pollinator community structure. By integrating measures of viral prevalence, viral load, and immune gene expression across multiple …

Cell Type-Specific Fatty Acid Signalling And Its Sex Dependence, Emeline Masterson

Graduate Studies Theses and Dissertations 2026

Dietary fat is a highly palatable, energy-dense nutrient whose oral detection powerfully shapes ingestion patterns and metabolic outcomes. Despite clear behavioral and physiological evidence that fat can evoke distinct taste signals, the cellular and molecular mechanisms underlying its transduction remain poorly understood. A critical gap exists in our understanding of the cell-type-specific molecular pathways and how these signals are modulated by hormonal status. This dissertation delineates estrogen-dependent plasticity in FA transduction within the peripheral taste system, revealing coordinated, sex and cell-type-specific modulation of these pathways. To understand the missing mechanisms, FA-evoked responses were compared in Type II cells from wild-type …