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In Vivo Expression Technology Identifies A Novel Virulence Factor Critical For Borrelia Burgdorferi Persistence In Mice, Tisha Choudhury Ellis, Sunny Jain, Angelika K. Linowski, Kelli Rike, Aaron Bestor, Patricia A. Rosa, Micah Halpern, Stephanie Kurhanewicz, Mollie W. Jewett Jan 2013

In Vivo Expression Technology Identifies A Novel Virulence Factor Critical For Borrelia Burgdorferi Persistence In Mice, Tisha Choudhury Ellis, Sunny Jain, Angelika K. Linowski, Kelli Rike, Aaron Bestor, Patricia A. Rosa, Micah Halpern, Stephanie Kurhanewicz, Mollie W. Jewett

Faculty Bibliography 2010s

Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during infection has proven difficult due to the low spirochete loads in the mammalian tissues. To overcome this challenge, we have developed an In Vivo Expression Technology (IVET) system for identification of B. burgdorferi genes expressed during an active murine infection. Spirochetes lacking linear plasmid (lp) 25 are non-infectious yet highly transformable. Mouse infection can be restored to these spirochetes by expression of the essential lp25-encoded pncA gene alone. Therefore, this IVET-based approach selects for in vivo-expressed promoters that drive expression of pncA resulting in the recovery …

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Skeletal Muscles Of Ambulant Children With Duchenne Muscular Dystrophy: Validation Of Multicenter Study Of Evaluation With Mr Imaging And Mr Spectroscopy, Sean C. Forbes, Glenn A. Walter, William D. Rooney, Dah-Jyuu Wang, Soren Devos, Jim Pollaro, William Triplett, Donovan J. Lott, Rebecca J. Willcocks, Claudia Senesac, Michael J. Daniels, Barry J. Byrne, Barry Russman, Richard S. Finkel, James S. Meyer, H. Lee Sweeney, Krista Vandenborne Jan 2013

Skeletal Muscles Of Ambulant Children With Duchenne Muscular Dystrophy: Validation Of Multicenter Study Of Evaluation With Mr Imaging And Mr Spectroscopy, Sean C. Forbes, Glenn A. Walter, William D. Rooney, Dah-Jyuu Wang, Soren Devos, Jim Pollaro, William Triplett, Donovan J. Lott, Rebecca J. Willcocks, Claudia Senesac, Michael J. Daniels, Barry J. Byrne, Barry Russman, Richard S. Finkel, James S. Meyer, H. Lee Sweeney, Krista Vandenborne

Faculty Bibliography 2010s

Purpose: To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. Materials and Methods: This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSA(max)), transverse …

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Incorporating Phylogenetic-Based Covarying Mutations Into Rnaalifold For Rna Consensus Structure Prediction, Ping Ge, Shaojie Zhang Jan 2013

Incorporating Phylogenetic-Based Covarying Mutations Into Rnaalifold For Rna Consensus Structure Prediction, Ping Ge, Shaojie Zhang

Faculty Bibliography 2010s

Background: RNAalifold, a popular computational method for RNA consensus structure prediction, incorporates covarying mutations into a thermodynamic model to fold the aligned RNA sequences. When quantifying covariance, it evaluates conserved signals of two aligned columns with base-pairing rules. This scoring scheme performs better than some other approaches, such as mutual information. However it ignores the phylogenetic history of the aligned sequences, which is an important criterion to evaluate the level of sequence covariance. Results: In this article, in order to improve the accuracy of consensus structure folding, we propose a novel approach named PhyloRNAalifold. It incorporates the number of covarying …

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Reliability Of The Woodway Curve (Tm) Non-Motorized Treadmill For Assessing Anaerobic Performance, Adam M. Gonzalez, Adam J. Wells, Jay R. Hoffman, Jeffrey R. Stout, Maren S. Fragala, Gerald T. Mangine, William P. Mccormack, Jeremy R. Townsend, Adam R. Jajtner, Nadia S. Emerson, Edward H. Robinson Iv Jan 2013

Reliability Of The Woodway Curve (Tm) Non-Motorized Treadmill For Assessing Anaerobic Performance, Adam M. Gonzalez, Adam J. Wells, Jay R. Hoffman, Jeffrey R. Stout, Maren S. Fragala, Gerald T. Mangine, William P. Mccormack, Jeremy R. Townsend, Adam R. Jajtner, Nadia S. Emerson, Edward H. Robinson Iv

Faculty Bibliography 2010s

A curved treadmill offers a practical method of assessing anaerobic power by enabling unrestricted running motion and greater sport specificity. The purpose of this research was to determine reliability of a curved treadmill (cTM) sprint test and to compare performance measures to the traditional Wingate anaerobic power test (WAnT) performed on a cycle ergometer. Thirty-two recreationally active men and women (22.4 +/- 2.8 yrs; 1.73 +/- 0.08 m; 74.2 +/- 13.2 kg) performed four familiarization trials on cTM, followed by two randomly assigned experimental trials consisting of one 30-second maximum effort on either cTM or WAnT. Each trial was separated …

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Chlamydia Trachomatis Tarp Harbors Distinct G And F Actin Binding Domains That Bundle Actin Filaments, Shahanawaz Jiwani, Stephenie Alwardo, Ryan J. Ohr, Adriana Romero, Brenda Nguyen, Travis J. Jewett Jan 2013

Chlamydia Trachomatis Tarp Harbors Distinct G And F Actin Binding Domains That Bundle Actin Filaments, Shahanawaz Jiwani, Stephenie Alwardo, Ryan J. Ohr, Adriana Romero, Brenda Nguyen, Travis J. Jewett

Faculty Bibliography 2010s

All species of Chlamydia undergo a unique developmental cycle that transitions between extracellular and intracellular environments and requires the capacity to invade new cells for dissemination. A chlamydial protein called Tarp has been shown to nucleate actin in vitro and is implicated in bacterial entry into human cells. Colocalization studies of ectopically expressed enhanced green fluorescent protein (EGFP)-Tarp indicate that actin filament recruitment is restricted to the C-terminal half of the effector protein. Actin filaments are presumably associated with Tarp via an actin binding alpha helix that is also required for actin nucleation in vitro, but this has not been …

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Release Of Proteins From Intact Chloroplasts Induced By Reactive Oxygen Species During Biotic And Abiotic Stress, Kwang-Chul Kwon, Dheeraj Verma, Shuangxia Jin, Nameirakpam D. Singh, Henry Daniell Jan 2013

Release Of Proteins From Intact Chloroplasts Induced By Reactive Oxygen Species During Biotic And Abiotic Stress, Kwang-Chul Kwon, Dheeraj Verma, Shuangxia Jin, Nameirakpam D. Singh, Henry Daniell

Faculty Bibliography 2010s

Plastids sustain life on this planet by providing food, feed, essential biomolecules and oxygen. Such diverse metabolic and biosynthetic functions require efficient communication between plastids and the nucleus. However, specific factors, especially large molecules, released from plastids that regulate nuclear genes have not yet been fully elucidated. When tobacco and lettuce transplastomic plants expressing GFP within chloroplasts, were challenged with Erwinia carotovora (biotic stress) or paraquat (abiotic stress), GFP was released into the cytoplasm. During this process GFP moves gradually towards the envelope, creating a central red zone of chlorophyll fluorescence. GFP was then gradually released from intact chloroplasts into …

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Examining Multi-Level And Inter-Organizational Collaborative Response To Disasters: The Case Of Pakistan Floods In 2010, Sana Khosa Jan 2013

Examining Multi-Level And Inter-Organizational Collaborative Response To Disasters: The Case Of Pakistan Floods In 2010, Sana Khosa

Electronic Theses and Dissertations

Catastrophic disasters are different than routine disasters and managing them requires the mobilization of inter-organizational, inter-governmental, cross-sectoral and international humanitarian support. The role of the international community through International Nongovernmental Organizations (INGOs), and multi-lateral organizations such as the United Nations (UN) becomes imperative when the scale of the disaster is unprecedented and difficult for a country to manage on its own. The initial response and relief phase of managing disasters is one in which many agencies with different expertise, capacities, working mandates, resources, skills, working cultures and norms come together to coordinate and collaborate to provide timely response and relief …

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The Devil Made Her Do It: Understanding Suicide, Demonic Discourse, And The Social Construction Of 'Health' In Yucatan, Mexico, Beatriz M. Reyes-Foster Jan 2013

The Devil Made Her Do It: Understanding Suicide, Demonic Discourse, And The Social Construction Of 'Health' In Yucatan, Mexico, Beatriz M. Reyes-Foster

Faculty Scholarship and Creative Works

In the state of Yucatan, Mexico, the suicide rate more than doubles the Mexican national average. This article uses ethnographic data to argue that 1) local understandings of suicide in Yucatán reflect a logic of health among Yucatec Maya people hinging on the belief that spiritual, bodily, and spatial balance must be maintained in order to prevent “illness,” understood as bodily and spiritual suffering; and 2) that Yucatec Maya users of Mexico’s public health system readily adapt the biomedical model to existing paradigms that comingle spiritual, mental, and bodily health due in great part to the inherent contradictions in both …

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Autonomous Recovery Of Reconfigurable Logic Devices Using Priority Escalation Of Slack, Naveed Imran Jan 2013

Autonomous Recovery Of Reconfigurable Logic Devices Using Priority Escalation Of Slack, Naveed Imran

Electronic Theses and Dissertations

Field Programmable Gate Array (FPGA) devices offer a suitable platform for survivable hardware architectures in mission-critical systems. In this dissertation, active dynamic redundancy-based fault-handling techniques are proposed which exploit the dynamic partial reconfiguration capability of SRAM-based FPGAs. Self-adaptation is realized by employing reconfiguration in detection, diagnosis, and recovery phases. To extend these concepts to semiconductor aging and process variation in the deep submicron era, resilient adaptable processing systems are sought to maintain quality and throughput requirements despite the vulnerabilities of the underlying computational devices. A new approach to autonomous fault-handling which addresses these goals is developed using only a uniplex …

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A Dynamic Enrollment Simulation Model For Planning And Decision-Making In A University, Luis Robledo Jan 2013

A Dynamic Enrollment Simulation Model For Planning And Decision-Making In A University, Luis Robledo

Electronic Theses and Dissertations

Decision support systems for university management have had limited improvement in the incorporation of new cutting-edge techniques. Most decisionmakers use traditional forecasting methods to base their decisions in order to maintain financially affordable programs and keep universities competitive for the last few decades. Strategic planning for universities has always been related to enrollment revenues, and operational expenses. Enrollment models in use today are able to represent forecasting based on historical data, considering usual variables like student headcount, student credit, among others. No consideration is given to students’ preferences. Retention models, associated to enrollment, deal with average retention times leaving off …

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Early And Intermediate Hospital-To-Home Transition Outcomes Of Older Adults Diagnosed With Diabetes, Jacqueline Lamanna Jan 2013

Early And Intermediate Hospital-To-Home Transition Outcomes Of Older Adults Diagnosed With Diabetes, Jacqueline Lamanna

Electronic Theses and Dissertations

Over 5 million older adults with diabetes are hospitalized each year. Though typically not the index condition that leads to hospitalization, diabetes control often decompensates during the course of an admission and necessitates changes in home self-management plans. The specific transitional care needs of older adults with diabetes have been largely unstudied. Transition theory provided the guiding framework for this research and proposes that each transition is a complex process created by the continuous interaction of personal, community, and societal-level conditions that facilitate or inhibit the health of a transition. Hospitalization has been described as a series of three successive, …

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Child Murder: A Re-Examination Of Durkheim's Theory Of Homicide, Melissa Tetzlaff-Bemiller Jan 2013

Child Murder: A Re-Examination Of Durkheim's Theory Of Homicide, Melissa Tetzlaff-Bemiller

Electronic Theses and Dissertations

The current study examines county-level characteristics and their impact on child homicide. This work uses Durkheimian theory and tests the concept of solidarity by using variables that constitute integration and regulation. In addition, some variables are drawn from other theoretical perspectives, mainly social disorganization and anomie theories, to better explore additional macro-level indicators. Data were obtained from multiple locations. Homicide data for children, from birth through five years, utilized in this work came from the National Incident-Based Reporting System. County level socio-demographics were obtained from the Census. Political party affiliation (Republican or Democrat) came from Politico, and religious data were …

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Sustainability Analysis Of Intelligent Transportation Systems, Tolga Ercan Jan 2013

Sustainability Analysis Of Intelligent Transportation Systems, Tolga Ercan

Electronic Theses and Dissertations

Commuters in urban areas suffer from traffic congestion on a daily basis. The increasing number of vehicles and vehicle miles traveled (VMT) are exacerbating this congested roadway problem for society. Although literature contains numerous studies that strive to propose solutions to this congestion problem, the problem is still prevalent today. Traffic congestion problem affects society’s quality of life socially, economically, and environmentally. In order to alleviate the unsustainable impacts of the congested roadway problem, Intelligent Transportation Systems (ITS) has been utilized to improve sustainable transportation systems in the world. The purpose of this thesis is to analyze the sustainable impacts …

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Victims Outside The Binary: Transgender Survivors Of Intimate Partner Violence, Xavier Diaz, Jan 2013

Victims Outside The Binary: Transgender Survivors Of Intimate Partner Violence, Xavier Diaz,

Electronic Theses and Dissertations

While research on intimate partner violence (IPV) has begun to include gay and lesbian relationships, these studies have almost entirely focused on cisgender relationships or victims. To date, little to no research exists on IPV in the transgender community. The current study explored accounts and meanings of IPV victimization as told by 18 transgender-identified survivors. Thirteen in-depth interviews and five open-ended questionnaires were analyzed from a modified grounded theory method through open and focused coding that revealed three broad and salient themes. First, the accounts of violence illustrated the role of transphobic and genderist attacks in the dynamics of abuse. …

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A Sustainability "Green" Certification Audit Of Food Service Operations And The Development Of A Restaurant Sustainability Instrument, Hans Hagglund Jan 2013

A Sustainability "Green" Certification Audit Of Food Service Operations And The Development Of A Restaurant Sustainability Instrument, Hans Hagglund

Electronic Theses and Dissertations

This study investigates current green restaurant certifications as well as developing a new more user certification. First, a fact finding investigation to find the most established and commonly utilized green restaurant certifications were compared. Second, a new green certification was developed. Third, chosen green restaurant certifications were compared. Lastly, the new green certification analyzed whether restaurants in the central Florida area utilized green practices. Data were collected in face to face sessions with restaurant managers during nonpeak hours of operation. There were numerous surveys utilized in this research study. The statistical methodology utilized in this study was average means and …

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Perceptions Of Senior Citizens In Central Florida Regarding Quality Of Care Under The Patient Protection And Affordable Care Act (Aca), Rafael Daney Jan 2013

Perceptions Of Senior Citizens In Central Florida Regarding Quality Of Care Under The Patient Protection And Affordable Care Act (Aca), Rafael Daney

HIM 1990-2015

On March 23, 2010, President Barack Obama signed the Patient Protection and Affordable Care Act (PPACA) into law. This reform, it is argued, is projected to increase insurance coverage of pre-existing conditions, to expand access to insurance for more than 30 million Americans, and to increase estimated National medical spending while lowering projected Medicare spending. This thesis sought to investigate and analyze the perceptions of senior citizens in Central Florida about PPACA and their perceived effects on the healthcare quality provided to them under this law. Four sections of PPACA bill, thought to specifically pertain to the elderly, were selected …

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Southern Honor: An Analysis Of Stand Your Ground Law In Southern Jurisdictions, Vaughn Glinton Jr. Jan 2013

Southern Honor: An Analysis Of Stand Your Ground Law In Southern Jurisdictions, Vaughn Glinton Jr.

HIM 1990-2015

In 2005, Florida became the first state to pass the heavily National Rifle Association, NRA, supported "Stand Your Ground" law. The most notable components of the law were abolishing the duty to retreat for someone who is not engaged in lawful activity and is in a place where he has the right to be, granting civil and criminal immunity to those using lawful force, and presuming that a person who is attacked in his dwelling, residence, and occupied vehicle has a reasonable fear of death or great bodily harm. The law was subject to a substantial amount of criticism because …

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Sanctions Without Humanitarian Implications - An Impossible Feat, Sangitha Palaniappa Jan 2013

Sanctions Without Humanitarian Implications - An Impossible Feat, Sangitha Palaniappa

HIM 1990-2015

This thesis focuses on the humanitarian implications of economic sanctions. States are increasingly using sanctions as a foreign policy tool, but the ramifications for the citizens of the country have yet to be analyzed in depth. Although sanctions are an extremely powerful foreign policy tool, the humanitarian implications are too drastic. There are two main outcomes of sanctions that states seek: the pressure of the sanctions forces the government to change their policy or the humanitarian implications force the citizens to revolt against the government. These outcomes rarely occur as we can see clearly in cases such as Cuba or …

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Understanding The Role Of Plasmodium Falciparum Vamp8 Snare Homologue, Katherine Ferreira Jan 2013

Understanding The Role Of Plasmodium Falciparum Vamp8 Snare Homologue, Katherine Ferreira

HIM 1990-2015

Malaria is one of the worlds most deadly infectious diseases and results in almost a million deaths each year, largely in children under the age of five in Sub-Saharan Africa. Outside Africa, malaria is responsible for a large number of cases in the Amazon rainforest of Brazil, Middle East, and in some areas of Asia [37]. According to the World Health Organization, there was an estimated 655, 000 deaths from malaria in 2012. Malaria is caused by a eukaryotic Apicomplexan parasite, Plasmodium, which has three distinct life cycles occurring in the midgut of the female Anopheles mosquito, the liver of …

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The Possible Role Of Burnout In Nursing Errors, Kelley Hoskins Jan 2013

The Possible Role Of Burnout In Nursing Errors, Kelley Hoskins

HIM 1990-2015

Nurse burnout and the commission of errors are two seemingly unrelated phenomena in the health care arena. Burnout was first described by Herbert J. Freudenberger in 1974 and has since been studied in many industries, including nursing. The issue of errors in health care has been a growing concern since the Institute of Medicine published the report, To Err is Human in 1999. Little research has been done to link burnout and the commission of errors. A literature review was performed to investigate these two issues. Peer-reviewed research articles were analyzed for contributing factors and effects on patient outcomes. The …

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A Dialogical Approach Of Group Identity Salience And The Academic Competence Of Nontraditional College Students, Robert Thally Jan 2013

A Dialogical Approach Of Group Identity Salience And The Academic Competence Of Nontraditional College Students, Robert Thally

HIM 1990-2015

As of 2007, approximately 73% of the 18 million college students in this country could be identified as nontraditional (Ross-Gordon, 2011). A key characteristic distinguishing this group from the traditional college student is the influence of multiple roles of the adult learner on the learning and engagement process (Keith, Byerly, Floerchinger, Pence, & Thornberg, 2006). Ross-Gordon remarks on some roles that may provide life experience, an asset to understanding theoretical constructs otherwise immaterial to younger, traditional learners. However, it is important to recognize the complex dynamic of conflicting roles as challenges to the academic competence of nontraditional college students. This …

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Diradical Intermediate Within The Context Of Tryptophan Tryptophylquinone Biosynthesis, Erik T. Yukl, Fange Liu, J. Krzystek, Sooim Shin, Lyndal M. R. Jensen, Victor L. Davidson, Carrie M. Wilmot, Aimin Liu Jan 2013

Diradical Intermediate Within The Context Of Tryptophan Tryptophylquinone Biosynthesis, Erik T. Yukl, Fange Liu, J. Krzystek, Sooim Shin, Lyndal M. R. Jensen, Victor L. Davidson, Carrie M. Wilmot, Aimin Liu

Faculty Bibliography 2010s

Despite the importance of tryptophan (Trp) radicals in biology, very few radicals have been trapped and characterized in a physiologically meaningful context. Here we demonstrate that the diheme enzyme MauG uses Trp radical chemistry to catalyze formation of a Trp-derived tryptophan tryptophylquinone cofactor on its substrate protein, premethylamine dehydrogenase. The unusual six-electron oxidation that results in tryptophan tryptophylquinone formation occurs in three discrete two-electron catalytic steps. Here the exact order of these oxidation steps in the processive six-electron biosynthetic reaction is determined, and reaction intermediates are structurally characterized. The intermediates observed in crystal structures are also verified in solution using …

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Imaging Of Benign Soft Tissue Tumors, Laura W. Bancroft, Christopher Pettis, Christopher Wasyliw Jan 2013

Imaging Of Benign Soft Tissue Tumors, Laura W. Bancroft, Christopher Pettis, Christopher Wasyliw

Faculty Bibliography 2010s

The evaluation of soft tissue tumors should be approached systematically, with careful assessment of the patient's age, clinical presentation, anatomical location of the mass, and MRI characteristics. The imaging evaluation of a suspected soft tissue mass begins with conventional radiography to exclude an underlying osseous lesion and assess for any lesional calcification. MRI is particularly useful in evaluating the signal intensity, enhancement pattern, and extent of soft tissue masses that can expand beyond fascial planes and involve the neurovascular bundle, joint, or bone. Among the common benign soft tissue tumors, a fairly definitive imaging diagnosis can be made in cases …

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Pheochromocytoma Of The Urinary Bladder: A Systematic Review Of The Contemporary Literature, Jonathan A. Beilan, Adrienne Lawton, Julio Hajdenberg, Charles J. Rosser Jan 2013

Pheochromocytoma Of The Urinary Bladder: A Systematic Review Of The Contemporary Literature, Jonathan A. Beilan, Adrienne Lawton, Julio Hajdenberg, Charles J. Rosser

Faculty Bibliography 2010s

Background: Pheochromocytoma (paraganglioma) of the urinary bladder is a rare tumor. Herein we sought to review the contemporary literature on pheochromocytomas of the urinary bladder in order to further illustrate the presentation, treatment options and outcomes of patients diagnosed with these tumors. Methods: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database and using the search terms "paraganglioma, pheochromocytoma, bladder." This search resulted in the identification of 186 articles published between January 1980 and April 2012 of which 80 articles were ultimately included in our analysis. Results: Pheochromocytomas usually …

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Proline-Dependent Regulation Of Clostridium Difficile Stickland Metabolism, Laurent Bouillaut, William T. Self, Abraham L. Sonenshein Jan 2013

Proline-Dependent Regulation Of Clostridium Difficile Stickland Metabolism, Laurent Bouillaut, William T. Self, Abraham L. Sonenshein

Faculty Bibliography 2010s

Clostridium difficile, a proteolytic Gram-positive anaerobe, has emerged as a significant nosocomial pathogen. Stickland fermentation reactions are thought to be important for growth of C. difficile and appear to influence toxin production. In Stickland reactions, pairs of amino acids donate and accept electrons, generating ATP and reducing power in the process. Reduction of the electron acceptors proline and glycine requires the D-proline reductase (PR) and the glycine reductase (GR) enzyme complexes, respectively. Addition of proline in the medium increases the level of PR protein but decreases the level of GR. We report the identification of PrdR, a protein that activates …

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International Society Of Sports Nutrition Position Stand: Energy Drinks, Bill Campbell, Colin Wilborn, Paul La Bounty, Lem Taylor, Mike T. Nelson, Mike Greenwood, Tim N. Ziegenfuss, Hector L. Lopez, Jay R. Hoffman, Jeffrey R. Stout, Stephen Schmitz, Rick Collins, Dough S. Kalman, Jose Antonio, Richard B. Kreider Jan 2013

International Society Of Sports Nutrition Position Stand: Energy Drinks, Bill Campbell, Colin Wilborn, Paul La Bounty, Lem Taylor, Mike T. Nelson, Mike Greenwood, Tim N. Ziegenfuss, Hector L. Lopez, Jay R. Hoffman, Jeffrey R. Stout, Stephen Schmitz, Rick Collins, Dough S. Kalman, Jose Antonio, Richard B. Kreider

Faculty Bibliography 2010s

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature on the safety and efficacy of the use of energy drinks (ED) or energy shots (ES). The ISSN has concluded the following. 1. Although ED and ES contain a number of nutrients that are purported to affect mental and/or physical performance, the primary ergogenic nutrients in most ED and ES appear to be carbohydrate and/or caffeine. 2. The ergogenic value of caffeine on mental and physical performance has been well-established but the potential additive benefits of other nutrients contained …

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Long-Term Exposure To Cigarette Smoke Extract Induces Hypomethylation At The Runx3 And Igf2-H19 Loci In Immortalized Human Urothelial Cells, Li-Mei Chen, Jennifer C. Nergard, Liqiang Ni, Charles J. Rosser, Karl X. Chai Jan 2013

Long-Term Exposure To Cigarette Smoke Extract Induces Hypomethylation At The Runx3 And Igf2-H19 Loci In Immortalized Human Urothelial Cells, Li-Mei Chen, Jennifer C. Nergard, Liqiang Ni, Charles J. Rosser, Karl X. Chai

Faculty Bibliography 2010s

Cigarette smoking is the single most important epidemiological risk factor for bladder cancer but it is not known whether exposure of urothelial cells to the systemic soluble contents of cigarette smoke is directly causative to bladder cancer and the associated epigenetic changes such as tumor suppressor gene hypermethylation. We undertook this study to investigate if long-term treatment of human urothelial cells with cigarette smoke extract (CSE) results in tumor suppressor gene hypermethylation, a phenotype that was previously associated with long-term constant CSE treatment of airway epithelial cells. We chronically treated an immortalized human urothelial cell line UROtsa with CSE using …

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Mmp-3 Contributes To Nigrostriatal Dopaminergic Neuronal Loss, Bbb Damage, And Neuroinflammation In An Mptp Mouse Model Of Parkinson's Disease, Young Cheul Chung, Yoon-Seong Kim, Eugene Bok, Tae Young Yune, Sungho Maeng, Byung Kwan Jin Jan 2013

Mmp-3 Contributes To Nigrostriatal Dopaminergic Neuronal Loss, Bbb Damage, And Neuroinflammation In An Mptp Mouse Model Of Parkinson's Disease, Young Cheul Chung, Yoon-Seong Kim, Eugene Bok, Tae Young Yune, Sungho Maeng, Byung Kwan Jin

Faculty Bibliography 2010s

The present study examined whether matrix metalloproteinase-3 (MMP-3) participates in the loss of dopaminergic (DA) neurons in the nigrostriatal pathway in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease with blood brain barrier (BBB) damage and infiltration of peripheral immune cells. Tyrosine hydroxylase (TH) immunostaining of brain sections from MPTP-treated mice showed that MPTP induced significant degeneration of nigrostriatal DA neurons. Moreover, FITC-labeled albumin detection and immunostaining revealed that MPTP caused damage to the BBB and increased the number of ED-1- and CD-3-immunopositive cells in the substantia nigra (SN). Genetic ablation of MMP-3 reduced the nigrostriatal DA neuron loss and …

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The Role Of Monitoring Interpretive Rates, Concordance Between Cytotechnologist And Pathologist Interpretations Before Sign-Out, And Turnaround Time In Gynecologic Cytology Quality Assurance Findings From The College Of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 1, Karen M. Clary, Diane D. Davey, Sonya Naryshkin, R. Marshall Austin, Nicole Thomas, Beth Anne Chmara, Chiara Sugrue, Joseph Tworek Jan 2013

The Role Of Monitoring Interpretive Rates, Concordance Between Cytotechnologist And Pathologist Interpretations Before Sign-Out, And Turnaround Time In Gynecologic Cytology Quality Assurance Findings From The College Of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 1, Karen M. Clary, Diane D. Davey, Sonya Naryshkin, R. Marshall Austin, Nicole Thomas, Beth Anne Chmara, Chiara Sugrue, Joseph Tworek

Faculty Bibliography 2010s

Context.-The College of American Pathologists (CAP) conducted a national survey of gynecologic cytology quality assurance (QA) practices. Experts in gynecologic cytology were asked to join 5 working groups that studied the survey data on different aspects of QA. Evaluating the survey data and follow-up questions online, together with a review of pertinent literature, the working groups developed a series of preliminary statements on good laboratory practices in cytology QA. These were presented at a consensus conference and electronic voting occurred. Objective.-To evaluate a set of QA monitors in gynecologic cytology. Working group 1 evaluated (1) monitoring interpretive rate categories for …

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Recalled Items And The American Board Of Pathology Certification Examinations What Constitutes Cheating?, Diane Davis Davey Jan 2013

Recalled Items And The American Board Of Pathology Certification Examinations What Constitutes Cheating?, Diane Davis Davey

Faculty Bibliography 2010s

No abstract provided.

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