Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Alabama at Birmingham

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 781 - 810 of 35953

Full-Text Articles in Entire DC Network

Chronic Inflammation Compromises Natural Killer Cell Phenotype And Function In Myeloid Leukemia, Valeriya Kuznetsova Jan 2025

Chronic Inflammation Compromises Natural Killer Cell Phenotype And Function In Myeloid Leukemia, Valeriya Kuznetsova

All ETDs from UAB

Chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) are blood malignancies characterized by clonal expansion and a compromised immune system. Tyrosine kinase inhibitors (TKI) revolutionized CML treatment; however, TKI discontinuation leads to relapses in half of the cases. Further, up to 10% of patients are TKI-resistant and develop a blast crisis resembling AML. Natural killer (NK) cells can clear malignant cells, representing a promising immunotherapy. However, NK cell activity is suppressed in leukemia, and the microenvironmental drivers of this impairment remain understudied. Despite this, the existing mouse models have not been tested to assess the effect of CML on …

Go to article

Alternative Splicing In The Brain: Across Disease States, Sexes, Regions, And Cell Types, Emma Finn Jones Jan 2025

Alternative Splicing In The Brain: Across Disease States, Sexes, Regions, And Cell Types, Emma Finn Jones

All ETDs from UAB

Molecular phenotype heterogeneity is prevalent across multiple contexts and is mediated by mRNA expression differences and the gene and isoform level. Isoform-level mRNA complexity in the brain is essential for healthy neurodevelopment, and perturbations in AS are associated with many neurological and psychiatric disorders. While previous research has examined how AS changes in the brain, there is still a gap in using newer techniques to study these changes with greater specificity. Therefore, we address this gap by using long-read and scRNA-seq technologies to study isoform-level diversity in AS across four contexts (i.e., disease, sex, region, and cell type) in the …

Go to article

Characterization Of The Roles Of U1-70k In Alternative Splicing And Nuclear Speckle Formation, Trenton Myers Paul Jan 2025

Characterization Of The Roles Of U1-70k In Alternative Splicing And Nuclear Speckle Formation, Trenton Myers Paul

All ETDs from UAB

RNA-binding proteins (RBPs) play critical roles in RNA processing and regulation. Among these RBPs, U1-70K is a key protein involved in RNA processing, nuclear speckle formation, and has implications in neurodegenerative diseases such as Alzheimer's. Despite its significance in transcription, RNA processing, nuclear speckle formation, and nonsense-mediated decay, studies on U1-70K have been limited primarily to its well-structured N-terminal domain due to challenges in solubilizing and expressing the full-length protein. In this dissertation, we address these challenges by optimizing cell strain and co expressing DnaK and DnaJ, enabling the successful expression, solubilization, and purification of full-length U1-70K. Using fluorescence polarization …

Go to article

The Power Of Connection: Unraveling The Significance Of Social Support In The Stress Levels Of Informal Black Women Caregivers, Antoinette Shantay Williams Jan 2025

The Power Of Connection: Unraveling The Significance Of Social Support In The Stress Levels Of Informal Black Women Caregivers, Antoinette Shantay Williams

All ETDs from UAB

This study examines how three types of social support—having someone to talk to, someone to help with activities, and someone to provide care—affect the stress levels of informal Black women caregivers compared to Black men, White men, and White women caregivers in the United States. It explores the intersection of race and gender, with a specific focus on how social support influences the emotional, financial, and physical stress levels of informal Black women caregivers. This research aimed to answer two questions. Does social support decrease stress levels among informal caregivers? Does the association between social support and stress levels differ …

Go to article

Perceptions And Preferences Of Virtual Health To Promote Exercise Among People With Physical Disabilities: An Exploratory Mixed Methods Study, Madison Mintz Jan 2025

Perceptions And Preferences Of Virtual Health To Promote Exercise Among People With Physical Disabilities: An Exploratory Mixed Methods Study, Madison Mintz

All ETDs from UAB

People with physical disabilities and mobility limitations can greatly benefit from participating in a physically active lifestyle and adopting health-promoting strategies and behaviors. Benefits of physical activity include better sleep quality and quantity; decreased anxiety; weight loss or healthy weight maintenance; and maintained or increased balance, coordination, strength, and endurance, to name a few. However, rates of physical activity and exercise participation are disproportionate among people with disabilities (PWD). Current literature suggests a myriad of barriers and environmental inaccessibility as a leading cause of PWD not engaging or meeting physical activity guidelines. However, community-based, virtually-delivered programs have become dramatically available …

Go to article

Cytotoxic, Genotoxic, And Metabolic Effects Of Dihydroxyacetone In Heart, Liver And Lung Models, Arlet Hernandez Jan 2025

Cytotoxic, Genotoxic, And Metabolic Effects Of Dihydroxyacetone In Heart, Liver And Lung Models, Arlet Hernandez

All ETDs from UAB

Dihydroxyacetone (DHA) is a triose sugar found as an active ingredient in sunless tanning products (STPs) and by-product in electronic cigarettes (e-cigarettes). DHA can rapidly be absorbed into cells and tissues and incorporated into several metabolic pathways through its conversion into dihydroxyacetone phosphate (DHAP). Previous studies have shown that DHA promotes cytotoxicity and genotoxicity primarily characterized in skin models. The extent of these effects in systemic models is highly cell-type specific. Here we investigate the cytotoxic, genotoxic, and metabolic effects of DHA across several cell models. First, we investigated the effects of DHA in a metabolically active cell line, hepatocellular …

Go to article

Predictors Of Antidepressant Use In Stroke Survivors And Evaluating The Role Of Time-Varying Depressive Symptoms On The Association Between Antidepressant Use And Stroke, Hely Divyanshu Nanavati Jan 2025

Predictors Of Antidepressant Use In Stroke Survivors And Evaluating The Role Of Time-Varying Depressive Symptoms On The Association Between Antidepressant Use And Stroke, Hely Divyanshu Nanavati

All ETDs from UAB

Depression is a mental health crisis affecting 21 million Americans. Consequently, antidepressants are one of the most prescribed classes of medications in the American population. Depression is also a common adverse outcome after stroke with one in three patients having depressive symptoms within the first year of their stroke recovery phase. Antidepressants are effective in the treatment and prevention of depressive symptoms in stroke patients. However, the overall antidepressant use in the acute post-stroke phase and the patient characteristics influencing the prevalence of receiving antidepressant prescriptions during acute stroke hospitalization are not known. Depression is also associated with higher risk …

Go to article

Vitamin D Receptor Signaling Antagonizes RorT Signaling To Reprogram Th17 Cells, Blake Frey Jan 2025

Vitamin D Receptor Signaling Antagonizes RorT Signaling To Reprogram Th17 Cells, Blake Frey

All ETDs from UAB

Vitamin D3 has long been associated with protection against a myriad of autoimmune diseases commonly linked to dysregulation of the T helper 17 (Th17) program. Th17 cells rely on the nuclear receptor (NR) RORγt as the master transcription factor for differentiation and function, establishing a metastate that can drive pro-inflammatory or alternative pathways depending on external cues. Vitamin D3 signals through another NR, the vitamin D receptor (VDR), to inhibit IL-17A in favor of the immunosuppressive cytokine IL-10; however, the precise mechanisms remain unclear. We developed a novel dual Vdr reporter and conditional knockout mouse model, and for the first …

Go to article

The Evolutionary Ecology Of Reproductive System Variation In Haploid-Diploid Freshwater Red Macroalgae, Sarah Connelly Jan 2025

The Evolutionary Ecology Of Reproductive System Variation In Haploid-Diploid Freshwater Red Macroalgae, Sarah Connelly

All ETDs from UAB

Reproductive systems describe the relative rates of sexual versus asexual reproduction and selfing versus outcrossing, governing the transmission of genetic diversity between generations and shaping evolutionary responses to environmental change. Though sex has inherent costs, it contributes to the reproductive system for most eukaryotes, generating incredible life cycle diversity. Life cycles are expected to be correlated with different reproductive systems. Diploid life cycles should be associated with outcrossing, whereas life cycles with a long-lived haploid phase are hypothesized to be associated with selfing and asexual reproduction. To test this hypothesis, we used ten polymorphic microsatellite loci to genotype 311 gametophytes …

Go to article

Targeted Exon Skipping Of Nf1 Exon 52 As A Mutation Specific Therapeutic For Neurofibromatosis Type 1, Cameron Lee Church Jan 2025

Targeted Exon Skipping Of Nf1 Exon 52 As A Mutation Specific Therapeutic For Neurofibromatosis Type 1, Cameron Lee Church

All ETDs from UAB

Modification of pre-mRNA splicing using antisense oligonucleotides (ASOs) can be used to skip one or more exons carrying pathogenic DNA sequence variants. Our previ-ously published data indicates NF1 exon 52 is a good target for exon skipping as a cDNA screen indicates an NF1 isoform lacking exon 52 maintains both high neurofi-bromin expression and the ability to suppress Ras activity. To develop an exon skipping approach, we designed antisense phosphorodiamidate morpholino oligomers (PMOs) to skip exon 52. Our lead PMO has a low IC50 of 45nM and is able to restore NF1 expres-sion and Ras-suppression in a cell line with …

Go to article

The Role Of The Executive Control Network In Social Functioning In Autism, Mckayla Kurtz Jan 2025

The Role Of The Executive Control Network In Social Functioning In Autism, Mckayla Kurtz

All ETDs from UAB

Social functioning difficulties are often seen in autism and impact one’s ability to engage in meaningful social interactions and to maintain social relationships. Emerging research suggests that executive function (EF) impairments may underlie these social challenges, though the neural mechanisms involved remain unclear. The current study aimed to investigate the relationship between the functional connectivity of the executive control network (ECN) and social functioning in autistic children using resting-state functional MRI (rsfMRI) data. Resting-state fMRI data was obtained from 95 autistic participants (ages 5-13 years) from the publicly available Autism Brain Imaging Data Exchange II (ABIDE-II) database. Data were preprocessed …

Go to article

Meibomian Gland Secretion And Ocular Surface Characteristics In A Young Adult Population, Zachary Reynard Jan 2025

Meibomian Gland Secretion And Ocular Surface Characteristics In A Young Adult Population, Zachary Reynard

All ETDs from UAB

BACKGROUND: Meibomian Gland Dysfunction (MGD) is a primary contributing factor in up to 86% of all dry eye disease. A common metric for assessing MGD is the Meibomian Gland Score (MGS), a summative scale which incorporates meibum expressibility and quality. Three deficiencies exist within the literature on MGD: 1) most research has been performed on an older population; 2) diagnostic criteria are variable across studies and 3) few studies have tracked changes over time. OBJECTIVES: 1) Evaluate the prevalence of MGD and dry eye disease in a population of young adults in an academic program; 2) establish characteristic values for …

Go to article

Single Nucleus Multiomics Reveals The Drought-Driven Gene Regulatory Atlas In Arabidopsis, Jinbao Liu Jan 2025

Single Nucleus Multiomics Reveals The Drought-Driven Gene Regulatory Atlas In Arabidopsis, Jinbao Liu

All ETDs from UAB

The regulation of gene expression in plant responses to drought has been thoroughly in-vestigated in previous studies. Despite this, a detailed understanding of the cell type-specific regulatory mechanisms, encompassing multi-layered biological processes, is lack-ing. In this study, we report the use of single nucleus multiomic analysis in Arabidopsis seedlings in response to drought stress. Our single-nuclei RNA (snRNA) analysis deline-ated 14 distinct clusters representing major root and shoot cell types and discovered new cell type-specific drought markers. Integration of snRNA with single-nuclei ATAC (snATAC) data in leaf epidermis, root endodermis, and guard cells revealed accessible chromatin regions (ACRs)-linked genes predominantly …

Go to article

The Development Of A Valid And Reliable Survey To Assess Sexual And Reproductive Health Knowledge, Practices, Beliefs, And Risk For Abuse In Adults With Spina Bifida, Betsy Hopson Jan 2025

The Development Of A Valid And Reliable Survey To Assess Sexual And Reproductive Health Knowledge, Practices, Beliefs, And Risk For Abuse In Adults With Spina Bifida, Betsy Hopson

All ETDs from UAB

Adults with spina bifida (SB) face significant sexual and reproductive health (SRH) challenges, including knowledge gaps, limited access to services, and increased vulnerability to abuse. Sexual health is critical for this population, as most now live into adulthood. By age 20, many individuals with SB are sexually active, and over 90% express a desire for sexual activity. However, only 5% have discussed SRH with a healthcare provider, leading to sexual dysfunction, low contraception use, and inadequate SRH knowledge. Despite guidelines from the Spina Bifida Association (SBA) advocating for patient-centered SRH communication, healthcare providers’ lack of training and discomfort in having …

Go to article

Scalable Resonance-Based Multi-Coil Inductive Links For Wireless Power Transmission And Passive Sensing In Biomedical Applications, Reepa Saha Jan 2025

Scalable Resonance-Based Multi-Coil Inductive Links For Wireless Power Transmission And Passive Sensing In Biomedical Applications, Reepa Saha

All ETDs from UAB

Type 2 Diabetes (T2D) has become a major health crisis, affecting up to 95% of the 38.4 million diabetes cases in the United States and costing approximately $327 billion annually. Current treatments mainly focus on symptom management rather than reversing the disease. However, clinical observations suggest a promising link between certain stomach surgeries, such as the removal of the upper stomach, and diabetes reversal within a year. This raises the possibility of anatomical changes influencing diabetes outcomes, though the underlying neural mechanisms remain unclear. This dissertation is organized into three interconnected research segments, each contributing to a platform that deepens …

Go to article

Controlled By Disorder: Modifications To An Unstructured C-Terminal Region Alter Srsf1'S Intramolecular Interactions And Tendency To Phase Separate, Talia Fargason Jan 2025

Controlled By Disorder: Modifications To An Unstructured C-Terminal Region Alter Srsf1'S Intramolecular Interactions And Tendency To Phase Separate, Talia Fargason

All ETDs from UAB

The protein Serine-Arginine-rich Splicing Factor 1 (SRSF1) is essential in multiple stages of the mRNA lifecycle, including alternative splicing, nonsense-mediated decay, and nuclear export. SRSF1’s dysfunction is linked to cancers, viral evasion, and developmental disorders. Its function depends on interactions between structured and unstructured regions, modulated by phosphorylation. However, the unstructured regions, while critical for regulation, contribute to protein insolubility, hindering full-length studies. Prior to the work presented here, structural studies of SRSF1 were limited to analysis of its isolated domains. This dissertation develops new techniques to characterize SRSF1, focusing on its intermolecular interactions driving phase separation and intramolecular interactions …

Go to article

Diurnal Function And Expression Of Aquaporins In The Mouse Kidney, Phi Hung Nguyen Jan 2025

Diurnal Function And Expression Of Aquaporins In The Mouse Kidney, Phi Hung Nguyen

All ETDs from UAB

Aquaporins (AQPs) are a family of proteins that play a major role in maintaining water homeostasis. Aquaporin 2 (AQP2) and aquaporin 3 (AQP3) are expressed in the collecting duct and regulated by the antidiuretic hormone arginine vasopressin (AVP) through the AVPR2 receptor. It is well known that biological circadian rhythms are critical for maintaining homeostasis. In both humans and rodents, the kidneys exhibit time-of-day-dependent changes in function. We hypothesized that there is a diurnal pattern in urine and/or plasma osmolality, and that this may reflect changes in kidney aquaporins in mice. Male and female C57BL/6J mice (10-11 weeks old) were …

Go to article

Mammonc-Db: A Proteo-Genomic Platform For Comprehensive Breast Cancer Data Analysis, Integration And Visualization, Santhosh Kumar Karthikeyan Jan 2025

Mammonc-Db: A Proteo-Genomic Platform For Comprehensive Breast Cancer Data Analysis, Integration And Visualization, Santhosh Kumar Karthikeyan

All ETDs from UAB

ABSTRACT In 2024, breast cancer (BCa) emerged as the most prevalent cancer among women, accounting for 15% of fatalities in the United States. BCa is a multifaceted disease characterized by various molecular alterations associated with tumor initiation, progression, and metastasis. Clinically, different treatments such as endocrine therapy, chemotherapy, and anti-HER2 therapy are employed based on the molecular subtypes of breast cancer. Despite initial treatment responses, some cases experience recurrence due to therapy resistance. The application of next-generation sequencing techniques and data analysis has significantly enhanced our understanding of BCa biology, including its initiation and progression. By exploring BCa multi-omics data, …

Go to article

Evaluating The Financial Strain Of Pediatric Firearm Injuries On Children’S Hospitals: The Moderating Effects Of State Firearm Legislation And Geographic Setting, Perry Ann Reed Jan 2025

Evaluating The Financial Strain Of Pediatric Firearm Injuries On Children’S Hospitals: The Moderating Effects Of State Firearm Legislation And Geographic Setting, Perry Ann Reed

All ETDs from UAB

This thesis evaluates the financial strain of pediatric firearm injuries on children’s hospitals, with a focus on the moderating effects of geographic setting and state firearm legislation. The purpose of the research is to investigate how the stringency of state firearm laws influences the financial impact of such injuries and to examine how the association between gun law stringency and pediatric injuries differs between rural and urban hospital settings. The study employs a multi-level regression analysis, utilizing data from children’s hospitals across different geographic locations. The results provide partial support for the hypotheses. Contrary to expectations, pediatric firearm injuries did …

Go to article

Elucidating The Role Of The Secondary Coordination Sphere In Tuning Reactivity Of Synthetic Heme Superoxide Complexes And Other Biologically Relevant Intermediates, Garrett B. Tolbert Jan 2025

Elucidating The Role Of The Secondary Coordination Sphere In Tuning Reactivity Of Synthetic Heme Superoxide Complexes And Other Biologically Relevant Intermediates, Garrett B. Tolbert

All ETDs from UAB

Tryptophan catabolizing human heme-dioxyganase enzymes have been linked to a multitude of disease conditions; therefore, understanding the mechanistic details of their function is of great interest to facilitate the design of effective inhibitors for therapeutic applications. Synthetic model systems have demonstrated dioxygenation of indole moieties, elucidating key mechanistic details of the overall reaction. However, the contrastingly low reactivity of the synthetic heme-superoxide intermediates compared to those of dioxygenase enzymes necessitates the revaluation of these models with direct relevance to their biological mode of action. Herein, we report detailed mechanistic studies on the reactivity of model porphyrin systems with installed non-covalent …

Go to article

Predictors Of Everyday Function Among Older Adults Using Data From The Active Clinical Trial., Deborah Awusuah Dadson Jan 2025

Predictors Of Everyday Function Among Older Adults Using Data From The Active Clinical Trial., Deborah Awusuah Dadson

All ETDs from UAB

The nature of the lifespan causes a decrease in the bodily functioning of people as they age which affects the ability to engage in activities of daily living (ADLs) and instrumental activities of daily living (IADLs), mostly amongst older adults. A reduction in the individual’s abilities combined with environmental changes can lead to functional decline impacting everyday function. The aim of this study was to examine the association between visual, cognitive and physical factors with everyday function (IADL/ADL) among older adults and assess whether social determinants of health (SDoH) measures moderate the associations of vision, cognitive and physical function with …

Go to article

Parental Monitoring, Peer Connectedness, And Potential Exposure To Stis In Adolescents Using The Youth And Risk Behavior Survey (Yrbs) Of 2021, Allyson L. Pullen Jan 2025

Parental Monitoring, Peer Connectedness, And Potential Exposure To Stis In Adolescents Using The Youth And Risk Behavior Survey (Yrbs) Of 2021, Allyson L. Pullen

All ETDs from UAB

Background: Adolescents are significantly affected by sexually transmitted infections (STIs), a public health challenge linked to high-risk sexual behaviors, including early sexual initiation, unprotected intercourse, multiple partners, and substance use. Protective factors such as parental monitoring and peer connectedness have demonstrated the potential to reduce adolescent risky behaviors. This study aims to examine the relationship between parental monitoring, peer connectedness, and potential exposure to STIs in high school students. Methods: This study analyzed data from the 2021 Youth Risk Behavior Survey (YRBS), focusing on potential STI exposure, parental monitoring, and peer connectedness among U.S. high school students. Potential STI exposure …

Go to article

Shear Bond Strength Of A Composite Resin To 3d-Printed Resins With Various Designed Surface Texture: An In-Vitro Study, Venkata Sruthi Surabathula Jan 2025

Shear Bond Strength Of A Composite Resin To 3d-Printed Resins With Various Designed Surface Texture: An In-Vitro Study, Venkata Sruthi Surabathula

All ETDs from UAB

Background: Three-dimensional (3D) printing has revolutionized dentistry by enabling the fabrication of interim restorations that protect prepared teeth and maintain aesthetics and function during prosthesis creation. These interim shells often require relining with composite resins for precise fitting and enhanced durability, relying on achieving a strong shear bond strength (SBS) between the 3D-printed shell and the composite resin. Surface roughness and texture are critical factors that create micro-mechanical retention sites, enhancing SBS by increasing surface area and improving adhesive properties through techniques like air-abrasion. Research into novel surface textures mimicking natural dentinal tubules aims to further boost bond strength, comparing …

Go to article

Increasing The Knowledge, Awareness, And Readiness To Change Of Cultural Sensitivity Among Public Health College Students, Margaret Enlow Jan 2025

Increasing The Knowledge, Awareness, And Readiness To Change Of Cultural Sensitivity Among Public Health College Students, Margaret Enlow

All ETDs from UAB

This research examined if a lecture-based intervention increased the DEI knowledge, awareness, and readiness to change in undergraduate public health students. Topics included a systematic review of DEI activities in undergraduate public health classrooms/academic programs, determining reliability of an adapted tool to measure knowledge, awareness, and readiness to change, and statistical analyses of pre- and post-data to determine knowledge, awareness, and readiness to change after students participated in the lecture-based intervention. The systematic review identified a gap in the literature regarding public health DEI education in the classroom. Through additional analyses, themes of DEI were identified in previous publications that …

Go to article

Point-Of-Care Portable Perfusion Phantom For Accurate Dce-Mri Measurement, Martin Dawson Holland Jan 2025

Point-Of-Care Portable Perfusion Phantom For Accurate Dce-Mri Measurement, Martin Dawson Holland

All ETDs from UAB

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) monitors the temporal changes in contrast agent concentration within human tissues to assess the pharmacokinetic parameters of that tissue. Traditionally, these scans are evaluated qualitatively, but quantitative DCE-MRI (qDCE) may improve patient care by enabling more objective and accurate data analysis. One significant challenge hindering the broader adoption of qDCE is the variability of data across different MRI machines. Each manufacturer employs unique hardware and software configurations, leading to inconsistencies in quantifying the contrast agent concentration in tissues and, consequently, the pharmacokinetic parameters. Even using the same scanner, measurements can drift due to hardware …

Go to article

Association Of Hospitals’ Organizational Characteristics And Market Factors Offering Integrative Medicine Services To Adult Cancer Patients, Sanober Ajani Jan 2025

Association Of Hospitals’ Organizational Characteristics And Market Factors Offering Integrative Medicine Services To Adult Cancer Patients, Sanober Ajani

All ETDs from UAB

Integrative medicine (IM) plays an important role in cancer symptom management by providing patients with a range of non-pharmacological options to help manage the physical and emotional symptoms associated with cancer and its treatment. More patients are seeking IM services due in part to a more holistic or patient-centered approach to cancer care, alleviating side effects from cancer treatments, improving quality of life, and enhancing cancer treatment effectiveness. Although the demand for IM services is increasing, there is a gap in our knowledge regarding which cancer hospitals are providing IM programs and what services are offered within these programs. Therefore, …

Go to article

Social Dominance And Cortical Neuronal Synchrony In Male Mecp2 Knockout Mice, Cesar Andres Acevedo Triana Jan 2025

Social Dominance And Cortical Neuronal Synchrony In Male Mecp2 Knockout Mice, Cesar Andres Acevedo Triana

All ETDs from UAB

Social behaviors are critical for the survival of individuals, and their dysfunction is common in several neuropsychiatric and neurodevelopmental disorders including autism, where impaired sociability is one of the core diagnostic symptoms and compromises the interpretation of social cues, with an apparent lack of interest in others. Among the neurodevel opmental disorders associated with autism, Rett syndrome (RTT) is a disorder predominantly affecting females and caused by spontaneous loss-of-function mutations in the X-linked MECP2 gene, which encodes the transcriptional regulator MeCP2 that regulates many critical genes. RTT individuals have impaired motor, cognitive, and social abilities most of which are recapitulated …

Go to article

Influence Of Socio-Demographic Factors And Environmental Justice Issues On Vulnerable Populations Exposed To Pollution, Aishwarya Kaushal Jan 2025

Influence Of Socio-Demographic Factors And Environmental Justice Issues On Vulnerable Populations Exposed To Pollution, Aishwarya Kaushal

All ETDs from UAB

As climate change intensifies environmental hazards and pollution impacts across the U.S., Alabama’s socio-demographically diverse regions face unique and disproportionate vulnerabilities. This dissertation investigates the intersection of socio-demographic factors, environmental justice, and the disproportionate impact of pollution and flood risks on vulnerable populations in Alabama. The first study assesses the role of elevation and socio-economic factors in influencing susceptibility to flooding in Jefferson County, revealing that low-income and minority groups are more likely to reside in high-risk flood zones. A detailed spatial analysis using 2D flood modeling identifies neighborhoods with high flood exposure, emphasizing the racial and economic disparities that …

Go to article

Exploring Nutritional Needs In Spinal Cord Injury: Dietitian Perspectives, Bowel Health, And Dietary Recommendations, Ayse Gul Zengul Jan 2025

Exploring Nutritional Needs In Spinal Cord Injury: Dietitian Perspectives, Bowel Health, And Dietary Recommendations, Ayse Gul Zengul

All ETDs from UAB

Spinal cord injury (SCI) is a global condition affecting millions of people and leading to life-altering health complications. It profoundly alters body composition and metabolic rate, which need to be addressed with SCI-specific nutritional strategies. Muscle atrophy, fat accumulation, and decreased energy expenditure often lead to secondary health complications such as chronic diseases and SCI-related health problems, including pressure injuries and bowel dysfunction. Although nutrition plays a critical role in SCI management, our understanding of specific dietary needs for this population remains incomplete. This dissertation aims to comprehensively investigate the nutritional challenges and needs of individuals with SCI, ultimately developing …

Go to article

Elucidating The Impact Of Ribosome Biogenesis On Breast Cancer, Amr Rafat Elhamamsy Jan 2025

Elucidating The Impact Of Ribosome Biogenesis On Breast Cancer, Amr Rafat Elhamamsy

All ETDs from UAB

Ribosome biogenesis, a complex and multi-step process that occurs predominantly in the nucleolus, plays a critical role in cellular function by mediating protein synthesis through the assembly of ribosomal RNAs (rRNAs) and ribosomal proteins into functional ribosomes. In cancer, dysregulation of this process is linked to the development of specialized ribosomes (onco-ribosomes) that support oncogenic translation programs, enhancing tumor progression and therapeutic resistance. This dissertation explores the interplay between ribosome biogenesis and cancer, focusing particularly on the role of RNA Polymerase I (RNA Pol I) activity under hypoxic conditions and rRNA modifications in breast cancer. My first study elucidates the …

Go to article

First Prev Next Last