Digital Commons Network^™

An Automation Framework Based On System Api To Improve The Execution Time And Reduce Test Flakiness, Tejaswini Subhash Chilke

All ETDs from UAB

Software Testing is an important activity in the software development life cycle. Software Testing is a process that ensures the quality of the software under development by evaluating whether it matches the requirement specifications provided by stakeholders and is defect-free. Software testing methodologies have evolved with the shift in the development models. Over the years new development model namely Agile is getting popular which practices a short release cycle typical of two to three weeks. The agile methodology requires a continuous cycle of coding and testing, thus reduced the time for elaborated testing. In addition to that modern software are …

Sialylation As A Novel Mechanism Of Radiation Resistance In Rectal Cancer, Mary Smithson

All ETDs from UAB

Locally advanced rectal cancer is treated with chemoradiotherapy followed by surgery. Most patients do not have a complete response to chemoradiotherapy, and the resistance mechanisms are poorly understood. We investigated the role of ST6GAL-1 in therapeutic resistance. ST6GAL-1 is a sialytransferase that adds the negatively charged sugar, sialic acid (Sia), to cell surface proteins in the Golgi altering their function. We hypothesized that ST6GAL-1 mediates resistance to chemoradiation in rectal cancer by inhibiting apoptosis. Patient derived xenograft (PDX) and organoid models of rectal cancer as well as rectal cancer cell lines SW837 and SW620 were assessed for ST6GAL-1 protein with …

Maxillary And Mandibular Expansion Treatment With Invisalign First: A Retrospective Study Of Virtual Prediction Versus Clinical Outcomes, Laura Constanza Rey Londono

All ETDs from UAB

Introduction: The purpose of this retrospective study is to evaluate the maxillary and mandibular expansion achieved with Invisalign First (Align Technology, San Jose, CA) in growing children. Methods: Clinical stereolithography (STL) models of 32 patients in the mixed dentition stage, treated with the Invisalign First, were extracted from the ClinCheck software and analyzed in Dolphin imaging (version 11.95 Premium, Chatsworth, Calif) at three timepoints: T1 (initial records), T2 (virtual outcome prediction), and T3 (achieved outcome). The recorded measurements included: upper and lower primary intercanine and permanent intermolar width, upper and lower primary intercanine and permanent intermolar gingival width, upper arch …

A History Of New Deal Archaeology In Alabama: Labor And Science In Economic Reform, Caleb Ross Butz

All ETDs from UAB

This thesis is a history of New Deal archaeology within the state of Alabama. It was designed to facilitate research with New Deal-era collections by providing a comprehensive contextual background. This thesis explores the relationship between the Works Progress Administration (WPA) laborers and the archaeological institutions of the period within the context of the Great Depression and the social democratic reforms of the New Deal. Labor, labor-time, and logistical information were gathered from the WPA Quarterly Progress Reports prepared by David L. DeJarnette from 1936 to 1942. An inventory of over 130 archaeological sites was compiled based on field reports …

An Analysis Of Preterm Birth Related To Sars-Cov-2 Infection By Race, Madeleine B. Mcgwin

All ETDs from UAB

Research investigating the association between pregnant women with COVID-19 infection and adverse birth outcomes, including preterm birth, having been contradicting. Individual differences between study populations, e.g., racial composition, may explain some of these inconsistencies. The aim of the present study is to determine if the association between SARS-CoV-2 infection and pre-term birth varies according to race. A cross-sectional study was conducted using data from the Vizient Clinical Data Base/Research Manager (CDB/RM). The study participants were women who gave birth in one of the Vizient facilities between March 2020 and January 2021. A positive COVID-19 test status was the primary exposure …

The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan

All ETDs from UAB

CD38 is a multifunctional protein that is expressed in many immune cells, modulating NAD metabolism, inflammation and oxidative stress. Recent studies suggest that CD38 is also implicated in tumor immunosuppression. However, the role of CD38 in anti-tumor immunity and tumor immune evasion, and mechanisms involved, are still unclear. We hypothesized that CD38 expression by immune cells constricts T cell-mediated anti-tumor immune responses and promotes tumor cell immune evasion. We investigated whether mice lacking CD38 (CD38-/-) had impaired tumor growth in subcutaneous, intraperitoneal and intravenous syngeneic tumor models. CD38-/- mice showed no difference in subcutaneous B16 melanoma tumor growth and pulmonary …

Disparities, Telemedicine, And Covid-19: Rhetorical Approaches To Health And Medicine For Positive Behavior Change In Older African American Women, Audrey S. Wrenn

All ETDs from UAB

Overlapping exigencies experienced during the COVID-19 pandemic illustrate the need for adaptable and flexible public health responses that include cultural perspectives and lived experiences of specific groups. The rhetoric surrounding COVID-19 has proven to be multifocal because of the social and environmental experiences occurring simultaneously. Americans experienced periods of civil unrest, unequitable health care, overall lifestyle changes, and an immediate shift to telehealth use as the pandemic unfolded. This research examines telehealth engagement during the pandemic among African American (AA) women ages 75 and older to indicate the benefits and challenges to patient care in a virtual environment and from …

Experience-Dependent Plasticitiy Of Functional Connectivity In Human Visual Cortex Following Central Vision Loss, Leland Lanelle Fleming

All ETDs from UAB

The human brain is shaped by a dynamic interplay between innate factors and life experiences. Neuroscience has long grappled with understanding this relationship, particularly with regard to how changes in experience impact the brain during adulthood. This question is especially important in the context of macular degeneration, a disease that causes significant visual impairment and drastically alters day-to-day visual experiences for individuals afflicted by the disease. Specifically, people with macular degeneration lose the ability to use vision in the center of the visual field, the region of the retina with the highest spatial resolution. Subsequently, these individuals must rely on …

The Impact Of Blimp1 On Etreg Stability And The Tumor Microenvironment, Michael Dixon

All ETDs from UAB

CD4+ Foxp3+ regulatory T (Treg) cells are responsible for maintaining immunological homeostasis and self-tolerance through the regulation of immune responses against foreign and self-antigens, and they comprise both central Treg and effector Treg (eTreg) subsets. Because of their ability to suppress potent immune responses, eTreg cells expressing the transcription factor Blimp1 are frequently recruited to the tumor microenvironment (TME) to suppress anti-tumor responses by tumor infiltrating effector cells. Here, we demonstrate in murine transplantable tumor models that Blimp1 is required for intratumoral eTreg stability and that loss of Blimp1 by intratumoral eTreg cells results in their reduced suppressive activity and …

Challenges For Nurse Anesthetists Re-Entering Practice Following Substance Use Disorder Treatment, T'Anya Marye Carter

All ETDs from UAB

Substance use disorder (SUD) is a persistent, relapsing condition that is present in approximately 10% of anesthesia providers, who, compared to other healthcare providers, face a greater risk of developing an SUD by virtue of constant access to medications. The ability of Certified Registered Nurse Anesthetists (CRNAs) to obtain employment or maintain employment after treatment for SUD treatment is not well documented. CRNAs in recovery from SUD in the United States experience challenges when attempting to return to work following treatment for SUD for reasons yet to be identified. The purpose of this qualitative multiple-case study was to explore the …

How Inflammation, High-Density Lipoproteins, And Genes Affect The Relationship Between Apol1 And Kidney Outcomes, Ninad S. Chaudhary

All ETDs from UAB

Over the past decade, the discovery of novel genetic loci on chromosome 22q, apolipoprotein-L1 (APOL1), has given insights into the racial differences in kidney outcomes at the population level. APOL1 risk alleles are unique to African ancestry and confer increased susceptibility to end-stage kidney disease (ESKD) especially among individuals without diabetes. However, the diseases do not occur in all who inherit these alleles. Current efforts are driven towards identifying the factors that can interact with APOL1 in the development of kidney diseases. This dissertation investigated whether the association between APOL1 and kidney outcomes is affected by inflammatory markers (AIM1), high-density …

Uab National Alumni Society House Dedicated, 2011, Uab Archives

Images of the Month from UAB Archives

Image ID: A2018-13P

UAB National Alumni Society House Dedicated, 2011

Diagnostic And Treatment Dilemma In Patient With Bleeding Varices And Portal Vein Thrombosis, Melissa Ruck, Nessy Abraham-Phillip

UAB Huntsville Research Day - All Presentations

2021 oral presentation

Darley-Usmar Named Senior Associate Dean For Research Compliance And Administration, Jessica Martindale

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No abstract provided.

Lahti Named Chair Of The Department Of Psychiatry And Behavioral Neurobiology, Alicia Rohan

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No abstract provided.

Sustained Cellular Immune Dysregulation In Individuals Recovering From Covid-19, Jeff Hansen

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No abstract provided.

Sustained Cellular Immune Dysregulation In Individuals Recovering From Sars-Cov-2 Infection, Mary Ashley Canevaro

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No abstract provided.

Uab Earns Women's Choice Award "Best Hospital" Designation For Six Areas, Alicia Rohan

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No abstract provided.

Lahti Named Chair Of The Department Of Psychiatry And Behavioral Neurobiology, Jessica Martindale

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No abstract provided.

Rudraraju Leads Team To Second Place In Aha Covid-19 Challenge, Adam Pope

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No abstract provided.

A Safe Holiday Connection, Alicia Rohan

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No abstract provided.

O'Neal Cancer Center's Office Of Community Outreach And Engagement Celebrates 25 Years Of Service, Staff

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No abstract provided.

Uab's 1917 Clinic Officially Relocates To Lakeview District, Alicia Rohan

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No abstract provided.

Uab Student Selected For Prestigious Gilman Scholarship, Staff

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No abstract provided.

Uab Awarded $48.3 Million Nasa Cold Stowage Ii Contract, Alicia Rohan

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No abstract provided.

Potential Preventative Treatment Demonstrated For Crohn's Disease, Jeff Hansen

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No abstract provided.

Learn Relevant Terminology For The Covid-19 Vaccine Rollout, Haley Herfurth

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No abstract provided.

Legendary Musician Greg Phillinganes Will Be A Uab Jemison Visiting Professor In 2021, Shannon Thomason

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No abstract provided.

Debunking The Myths About The Covid-19 Vaccine, Staff

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No abstract provided.

Vaccines Bring New Holiday Cheer To Uab's Medical Campus, Haley Herfurth

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No abstract provided.