Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Alabama at Birmingham

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 6871 - 6900 of 36199

Full-Text Articles in Entire DC Network

Validation Of 2-Methylethcathinone, 3-Methylethcathinone, And 4-Methylethcathinone, Tara Federico Jan 2021

Validation Of 2-Methylethcathinone, 3-Methylethcathinone, And 4-Methylethcathinone, Tara Federico

All ETDs from UAB

Novel psychoactive substances (NPS), also known as designer drugs or legal highs, have been gaining popularity since their emergence in the early 1980s. These manufactured drugs are based on the structure of already popularized drugs, with small structural changes creating new analogues of the drugs. Such is the case for constitutional isomers 2-methylethcathinone (2-MEC), 3-methlyethcathinone (3-MEC), and 4-methlyethcathinone (4-MEC), which differ in only the position of a methyl group on the benzene ring.The ability to separate and differentiate between isomers is an important issue in forensic drug chemistry and toxicology sections, especially if the isomers have different legal statuses. Techniques …

Go to article

Cognitive Progression And Care Patterns In All-Cause Dementia By Prior Cancer Diagnosis, Mackenzie Elisha Fowler Jan 2021

Cognitive Progression And Care Patterns In All-Cause Dementia By Prior Cancer Diagnosis, Mackenzie Elisha Fowler

All ETDs from UAB

Cancer and dementia are common aging-related diseases. Cancer and itstreatments are associated with cognitive impairment referred to as cancer-related cognitive impairment (CRCI). Dementias demonstrate similar impairment. Only one study has examined the longitudinal association between cancer and dementia. This dissertation goes beyond limitations of the prior study and has three aims: 1.) to evaluate dementia progression by prior cancer diagnosis, 2.) to evaluate progression of all-cause dementia by cancer treatments, and 3.) to evaluate patterns and predictors of care among dementia patients by cancer history. This study uses EHR data to evaluate cognitive progression by cancer history /cancer treatment characteristics, …

Go to article

“Her Feeling Had Come Too Late”: Emotion And Time In Virginia Woolf’S Modernism, Madison Frost Jan 2021

“Her Feeling Had Come Too Late”: Emotion And Time In Virginia Woolf’S Modernism, Madison Frost

All ETDs from UAB

Mikhail Bakhtin’s idea of chronotope, or time-space, encompasses the idea that time and space cannot be separated from one another; they are intertwined. This concept of Bahktin’s is seen in Virginia Woolf’s To the Lighthouse, Mrs. Dalloway, and Orlando because of Woolf’s aim to more accurately depict the reality of modern life, something she deems necessary for modern writers in her essay “Modern Fiction.” Woolf makes use of various narrative techniques to experiment with her illustration of everyday life where she focuses heavily on the depiction of time-space through her illustration of consciousness. Woolf is able to add emotion to …

Go to article

A Power Optimized Power Low-Noise High Linearity Rf Amplifier For Iot Applications, Shaoyu Fu Jan 2021

A Power Optimized Power Low-Noise High Linearity Rf Amplifier For Iot Applications, Shaoyu Fu

All ETDs from UAB

Recently, Ultra-Wide Band (UWB) technology has gradually become the focus of research in the wireless communication field. It is regarded as one of the key technologies of the next generation wireless communication system. FCC passed the UWB commercialization specification on February 14, 2002, the world’s first, allowing the use of low-power UWB systems in the 3.1 GHz to 10.6 GHz frequency band. UWB has more bandwidth than other wireless technologies that can be used, and at the same time it won’t seriously interfere with other wireless communication systems located in the same frequency band. In terms of transmission speed, UWB …

Go to article

Evaluating The Turning Point Of Cardiovascular Health In Children With Sickle Cell Disease, Najibah Galadanci Jan 2021

Evaluating The Turning Point Of Cardiovascular Health In Children With Sickle Cell Disease, Najibah Galadanci

All ETDs from UAB

Cardiopulmonary disorders, including pulmonary hypertension, chronic lung disease, diastolic dysfunction and congestive heart failure, are among the most common complications in sickle cell disease (SCD). Many of these complications are identified in adulthood when patients develop irreversible clinical symptoms. General improvement in healthcare and disease management is allowing more children with SCD to reach adulthood, leading to the growing interest in preventing disease-specific complications to improve morbidity and mortality rates. Although cardiac abnormalities are common, it is unknown when cardiac dysfunction appears in the course of SCD.This dissertation utilized the Dissemination and Implementation of Stroke Prevention Looking at the Care …

Go to article

The Role Of Visa Status And Acculturation In The Health Of Us Immigrants, Serra Sevde Hatipoglu Jan 2021

The Role Of Visa Status And Acculturation In The Health Of Us Immigrants, Serra Sevde Hatipoglu

All ETDs from UAB

Using data from the 2003 New Immigrant Survey, I examined the association between visa status and acculturation with physical, mental, and self-rated health among immigrants residing in the United States. The primary predictor variable in the study is immigrant visa status. The outcome variables of interest include physical health as any morbidity (chronic diseases), mental health as depressed (as defined by the DSM-IV) and self-rated health (poor self-rated health). Using logistic regressions, I found those with unfavorable visa statuses have worse mental, physical, self-rated health compared to the favorable visa holders. I used inverse odds ratio weighted (IORW) mediation method …

Go to article

Identifying Novel Therapeutics And Therapeutic Entry Points For The Treatment Of Duchenne Muscular Dystrophy Through Regulation Of Gene Expression, Rylie Maria Hightower Jan 2021

Identifying Novel Therapeutics And Therapeutic Entry Points For The Treatment Of Duchenne Muscular Dystrophy Through Regulation Of Gene Expression, Rylie Maria Hightower

All ETDs from UAB

My graduate research has primarily focused on genetic and epigenetic modifiers of Duchenne muscular dystrophy and understanding how those modifiers can be used as novel therapeutic entry points for treatment. A vast array of promising therapeutic strategies is being explored outside the realm of directly targeting dystrophin deficiency. This is primarily due to the lack of successful clinical trials that have demonstrated the ability to benefit a significant number of DMD patients. Here, I have expanded the field’s understanding of using the regulation of gene expression as a way to target dystrophin-deficiency associated pathology through, 1) therapeutic treatment of a …

Go to article

Undergraduate Students’ Perspectives On Mental Health Services, Resources, And Supports During Covid-19: A Qualitative Dissertation, Amy Hutson Chatham Jan 2021

Undergraduate Students’ Perspectives On Mental Health Services, Resources, And Supports During Covid-19: A Qualitative Dissertation, Amy Hutson Chatham

All ETDs from UAB

During the COVID-19 pandemic, increased isolation from supportive relationships, uncertainty about the future, fear of illness, and lack of traditional life-events took a toll on university student mental health. It is important to understand undergraduate students’ mental health needs during the COVID-19 pandemic and their desires for support from their institutions of higher education. Existing studies have documented increased rates of depression, stress, and anxiety among university undergraduates; however, these studies rarely illuminate students’ perspectives on mental health services, resources, and supports that they need during and because of the COVID-19 pandemic. This phenomenological study explored the perspectives of undergraduate …

Go to article

Local Priming Of Long-Lived Tcf1+ Memory Cd8+ T Cell Responses In The Spleen During Influenza Virus Infection By Lung Derived Migratory Dendritic Cells, Meagan Jenkins Jan 2021

Local Priming Of Long-Lived Tcf1+ Memory Cd8+ T Cell Responses In The Spleen During Influenza Virus Infection By Lung Derived Migratory Dendritic Cells, Meagan Jenkins

All ETDs from UAB

Initiation of CD8+ T cell responses to influenza virus infection requires the trafficking of activated lung-migratory dendritic cells (mDCs) from the lung into the lung-draining mediastinal LN (med-LN). As such, when mDCs are absent from the lungs or are unable to migrate into the med-LN, T cell responses are severely compromised, and the mortality rate increases in mouse models of influenza infection. Importantly, it is generally considered that mDCs die shortly after reaching the med-LN. Thus, the current paradigm suggests that priming of all subsets of influenza-specific CD8+ T cell responses by mDCs takes place solely in the med-LN. Recent …

Go to article

Man Enough: Exploring The Gendered Experiences Of High-Achieving Black Men In Higher Education, Christopher E. Jones Jan 2021

Man Enough: Exploring The Gendered Experiences Of High-Achieving Black Men In Higher Education, Christopher E. Jones

All ETDs from UAB

Research regarding Black males in higher education has become an important endeavor for colleges and universities seeking to increase their graduation rates. Much of the previous research and practices have used a deficit-based approach explaining Black males’ low levels of academic achievement as primarily the result of them being underprepared. This ignores the contributions of Black males who do excel academically while minimizing the role their racialized gender plays in their outcomes. This dissertation focuses on an anti-deficit approach by exploring how high-achieving Black college males’ perceptions of manhood and masculinity have contributed to their overall academic success. Even though …

Go to article

On The Security And Usability Of New Paradigms Of Web Authentication, Mohammed Jubur Jan 2021

On The Security And Usability Of New Paradigms Of Web Authentication, Mohammed Jubur

All ETDs from UAB

Passwords are widely used by web services to authenticate their users. Unfortunately, passwords suffer from several well-documented security and usability issues. The two of the main techniques to address password problems are password managers and two-factor authentication (2FA), which form the central focus of this dissertation work. In particular, we explore the security and usability of newly proposed and emerging forms of password managers and 2FA systems. We first investigate a “store-less” online password manager that can prevent the leakage of the passwords from the password manager service itself. We also design and evaluate a new 2FA scheme that offers …

Go to article

Viral Load Is Not A Predictor For Hearing Loss In Children With Congenital Cytomegalovirus Infection, Nazia Kabani Jan 2021

Viral Load Is Not A Predictor For Hearing Loss In Children With Congenital Cytomegalovirus Infection, Nazia Kabani

All ETDs from UAB

Background: Congenital cytomegalovirus (cCMV) infection is a leading non-genetic cause of sensorineural hearing loss (SNHL) in children. Most infants (~90%) with cCMV have no clinical abnormalities at birth (asymptomatic cCMV), but 10-15% of these children develop SNHL. Due to lack of biomarkers, it is currently not possible to identify asymptomatic infants at-risk for hearing loss.Objective: To determine whether newborn viral load (VL) levels are predictive of hearing loss in children with asymptomatic cCMV. Methods: As part of the NIDCD CHIMES study, newborns at seven U.S. medical centers were screened for CMV by saliva PCR and enrolled in a follow-up study …

Go to article

A Lean Six Sigma Evaluation And Cost Analysis Of Alabama’S Oral Fluid Roadside Screening And Confirmation Testing Program, Minjee Kim Jan 2021

A Lean Six Sigma Evaluation And Cost Analysis Of Alabama’S Oral Fluid Roadside Screening And Confirmation Testing Program, Minjee Kim

All ETDs from UAB

In recent years, oral fluid has emerged as a vital biological specimen for driving under the influence of drug (DUI/D) cases among toxicology laboratories. Oral fluid possesses numerous advantages. The collection process is non-invasive, rapid, and simple compared to other traditional biological specimen, such as blood or urine. Due to its simplicity of collection, oral fluid can be collected proximate to the actual time of driving, traffic stop, or crash. Oral fluid as a biological specimen is also able to capture active parent drugs of recent use, especially for drugs that were administered orally. However, because oral fluid testing program …

Go to article

Heads Or Tails? Structural Studies Of Host Interaction And Molecular Piracy In Bacteriophages, James Lewis Kizziah Jan 2021

Heads Or Tails? Structural Studies Of Host Interaction And Molecular Piracy In Bacteriophages, James Lewis Kizziah

All ETDs from UAB

Staphylococcus aureus is an opportunistic human pathogen dependent mainly on bacteriophages (phages) for dissemination of the virulence factors that contribute to its pathogenicity. Most phages have double-stranded DNA (dsDNA) genomes which are packaged into protein capsids attached to tails of varying morphology to form their complete virion structures. S. aureus pathogenicity islands (SaPIs) are highly specialized mobile genetic elements that encode various virulence factors and have been named molecular pirates for their ability to parasitize certain helper phages. SaPI1 is capable of hijacking virions constructed by the helper phage 80α, partly by altering the size of the capsid to only …

Go to article

Inducible T Cell Costimulator Stabilizes Regulatory T Cell Phenotype And Controls Host-Microbiota Interactions To Reduce Susceptibility To Intestinal Inflammation, Ashley Elizabeth Landuyt Jan 2021

Inducible T Cell Costimulator Stabilizes Regulatory T Cell Phenotype And Controls Host-Microbiota Interactions To Reduce Susceptibility To Intestinal Inflammation, Ashley Elizabeth Landuyt

All ETDs from UAB

Genome wide association studies (GWAS) have identified a loss-of-function mutation in the gene encoding inducible T cell costimulator ligand (ICOSL) as correlating with inflammatory bowel disease (IBD). The reason for this association was largely unknown. ICOS signals have been implicated in controlling the dynamics of regulatory T (Treg) cells, which are essential to intestinal homeostasis. Compared to WT mice, ICOS-deficient mice possessed fewer Treg cells in the colonic lamina propria (cLP). The deficit in ICOS-deficient Treg cell numbers was attributable to preferential loss of Foxp3 expression. Bisulfite sequencing revealed that ICOS-deficient Treg cells did not demethylate conserved noncoding sequence 2 …

Go to article

Japonisme And Modernity In Thirty-Six Views Of The Eiffel Tower By Henri Riviere, Yen-Hua Liu Jan 2021

Japonisme And Modernity In Thirty-Six Views Of The Eiffel Tower By Henri Riviere, Yen-Hua Liu

All ETDs from UAB

This thesis examines the intersection of Japonisme and modernity in Henri Rivière’s lithographic album, Thirty-Six Views of the Eiffel Tower (1902). While paying homage to Hokusai’s Thirty-Six Views of Mount Fuji, Rivière represents thirty-six lithographs of modernized Paris. Rivière’s concept of modernity in the album goes beyond simply depicting the modern cityscape with the recently-built Eiffel Tower. His choice of lithography, usage of photographs, and innovative visual strategies indicate that the album is also a representation of modern life in the last decade of the nineteenth century.Modernity in this album operates on multiple levels. In addition to embodying changing fashions …

Go to article

Mucus Matters: Mucociliary Physiology In Chronic Lung Diseases, Jacelyn Emily Peabody Lever Jan 2021

Mucus Matters: Mucociliary Physiology In Chronic Lung Diseases, Jacelyn Emily Peabody Lever

All ETDs from UAB

The mucociliary escalator is an innate defense mechanism in the lung comprised of the ciliated, pseudostratified epithelium that lines the conducting airways and the mucus that sits atop the cilia. Mucus traps inhaled particulate matter/pathogens, and the cilia brush works in concert to propel the mucin gel proximally. Therefore, proper mucociliary physiology is critical to maintaining lung health. A metachronal wave propagated across the epithelium can occur when the phase of the ciliary stroke is shifted in time relative to its neighbors. Metachrony has been hypothesized to help overcome the viscoelastic forces required for the propulsion of mucus. Still, its …

Go to article

Japonisme And Modernity In Thirty-Six Views Of The Eiffel Tower By Henri Riviere, Yen-Hua Liu Jan 2021

Japonisme And Modernity In Thirty-Six Views Of The Eiffel Tower By Henri Riviere, Yen-Hua Liu

All ETDs from UAB

This thesis examines the intersection of Japonisme and modernity in Henri Rivière’s lithographic album, Thirty-Six Views of the Eiffel Tower (1902). While paying homage to Hokusai’s Thirty-Six Views of Mount Fuji, Rivière represents thirty-six lithographs of modernized Paris. Rivière’s concept of modernity in the album goes beyond simply depicting the modern cityscape with the recently-built Eiffel Tower. His choice of lithography, usage of photographs, and innovative visual strategies indicate that the album is also a representation of modern life in the last decade of the nineteenth century. Modernity in this album operates on multiple levels. In addition to embodying changing …

Go to article

Investigating Pathological Features Of Tdp-43 In Neurodegeneration, Joshua Mathew Marcus Jan 2021

Investigating Pathological Features Of Tdp-43 In Neurodegeneration, Joshua Mathew Marcus

All ETDs from UAB

Transactivation response element (TAR) DNA binding protein of 43 kDa (TDP-43) is an essential RNA-binding protein required for coordinating multiple aspects of RNA metabolism. TDP-43 is multifunctional in both nuclear and cytoplasmic cellular compartments and shuttling in and out of the nucleus is an integral part of TDP-43 function. Nuclear depletion and cytoplasmic accumulation of TDP-43, aggregation of TDP-43 within inclusion bodies in the cytoplasm, and aberrant post-translational modifications and truncation of TDP-43 are all common pathological features of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). Localization of TDP-43 is connected to essential …

Go to article

Omics Discovery For Cardiometabolic Traits In African Americans, Bre Ashanti Minniefield Jan 2021

Omics Discovery For Cardiometabolic Traits In African Americans, Bre Ashanti Minniefield

All ETDs from UAB

Research shows African Americans are more likely to suffer from a chronic disease compared to other American populations. Due to the fact that African Americans are extremely underrepresented within human health research, the potential biological causes of the racial/ethnic differences are not well understood. Some of these health differences may be due to genomic variations within either the mitochondrial genome, nuclear genome, or both. To aid the revolution of inclusive human health research, we examined genomic factors related to cardiometabolic diseases in African Americans.African Americans have the highest prevalence of hypertension compared to all other American populations. With the majority …

Go to article

Alternative Splicing Of Anxa7 Dictates Receptor Tyrosine Kinase Fates In Glioblastoma, Sindhu Nair Jan 2021

Alternative Splicing Of Anxa7 Dictates Receptor Tyrosine Kinase Fates In Glioblastoma, Sindhu Nair

All ETDs from UAB

Alternative splicing (AS) is a tightly regulated process essential for lineage specification in complex tissues like the brain. Dysregulated splicing in glioblastoma (GBM) is a mechanism exploited by tumor cells to retain or splice out exons consequently rewiring isoform-specific protein interactions to sustain tumor phenotypes. Receptor tyrosine kinases (RTK) amplifications are frequent events in GBM driving tumor growth and progression and are key targets for chemotherapy. However, RTK targeting in GBM has achieved limited success predominantly due to adaptive mechanisms of resistance in a constantly evolving tumor microenvironment. Clonal populations and crosstalk between RTKs sustain heterogeneity within a tumor leading …

Go to article

The Effects Of Implantoplasty On Implant Design Characteristics And Mechanical Strength, Peter Nasseh Jan 2021

The Effects Of Implantoplasty On Implant Design Characteristics And Mechanical Strength, Peter Nasseh

All ETDs from UAB

Implantoplasty is defined as the mechanical removal of the implant threads and the macroscopically rough implant surface. Clinical outcomes such as probing depth and bleed-ing on probing measurements were shown to improve significantly after implantoplasty and peri-implant bone stability was achieved in the majority of the cases.This in-vitro study aims to investigate the effects of implantoplasty on the implant’s maximum compressing force and the type of failure that occurred on different implant sys-tems with different sizes, materials, collar designs and prosthetic connections. A total of 132 screw-shaped titanium implants from different manufacturers (Bi-oHorizons, Zimmer Biomet, and Nobel Biocare) and different …

Go to article

Pride In Policing: Perspectives Of Lgbtq Police Officers, Tyler Nixon Jan 2021

Pride In Policing: Perspectives Of Lgbtq Police Officers, Tyler Nixon

All ETDs from UAB

Most research studying diversity in policing has focused on women and people of color as the target groups to be recruited and hired. Few scholars have examined the topic of Lesbi-an, Gay, Bisexual, Transgender, Queer/Questioning, Intersex, and Asexual (also known as LGBTQ+) individuals in law enforcement, resulting in a lack of awareness of their poten-tial benefits for the profession. Moreover, the few existing studies in this area tend to doc-ument the negative workplace experiences of openly gay officers, particularly with respect to their interactions with colleagues. While it is important to understand the challenges faced by nontraditional race and gender …

Go to article

High-Pressure Phase Diagram Of Ferromagnetic Superconductor Eu(Fe0.75ru0.25)2as2, Zachary Taylor Nix Jan 2021

High-Pressure Phase Diagram Of Ferromagnetic Superconductor Eu(Fe0.75ru0.25)2as2, Zachary Taylor Nix

All ETDs from UAB

Eu(Fe0.75Ru0.25)2As2 is an intriguing system with unusual coexistence of superconductivity (TC≈23 K) and ferromagnetism (Tm≈20 K) and provides a unique platform to study of the nature of such coexistence. To establish a microscopic magnetic phase diagram of the recent doped 122-type ferromagnetic superconductor Eu(Fe0.75Ru0.25)2As2, time-resolved synchrotron Mössbauer experiments in 151Eu have been performed on a single crystalline sample under hydrostatic pressure and low temperatures. Upon compression, the magnetic ordering temperature first increases sharply from 20 K at ambient pressure to 53 K at 10 GPa. With further compression, the magnetic ordering temperature decreases and the magnetic order is fully suppressed …

Go to article

Effectiveness Of Maxillary Molar Intrusion With The Invisalign System For Correction Of Anterior Open Bites, Logan Icenhour Jan 2021

Effectiveness Of Maxillary Molar Intrusion With The Invisalign System For Correction Of Anterior Open Bites, Logan Icenhour

All ETDs from UAB

Objective: The purpose of this study is twofold: To assess the amount of molar intrusion that can be predictably be achieved with clear aligners (Invisalign, Align Technology, Santa Clara, CA, USA) and to quantitatively document the dental and skeletal changes resulting from anterior open bite correction. Methods: This retrospective case-series study analyzed lateral cephalograms of 23 adult anterior open bite patients treated with Invisalign. Pre-treatment (IN) and post-treatment (FN) cephalograms were traced to determine changes as a result of treatment. 13 different variables were measured, 6 angular and 7 linear. All patients were treated consecutively by a single, experienced Invisalign …

Go to article

Financial Performance Of Participating Hospitals In Accountable Care Organizations, Abdulrhman Alzhrani Jan 2021

Financial Performance Of Participating Hospitals In Accountable Care Organizations, Abdulrhman Alzhrani

All ETDs from UAB

The study examines the influence of accountable care organizations ACO participation on hospital financial performance. It poses two research questions: 1) how does ACO participation influence hospital financial performance? 2) How do organizational factors- hospital size, electronic health records (EHR) utilization, and ambulatory services- moderate the relationship between hospital ACO participation and financial performance? The study used longitudinal sample of general and surgical hospitals operating in United States from 2009 to 2017. The data were obtained from several sources including American Hospital Association (AHA), AHA survey of care system and payment, hospital cost reports, AHA information technology and Area Health …

Go to article

The Effects Of Pubertal Timing On Psychosocial Outcomes In Adulthood, Marlon Goering Jan 2021

The Effects Of Pubertal Timing On Psychosocial Outcomes In Adulthood, Marlon Goering

All ETDs from UAB

Pubertal timing has been shown to be an important predictor of adolescents’ engagement in delinquent activities, development of depressive symptoms, and academic success. Less understood is whether early or off-time pubertal timing put adolescents at risk for detrimental outcomes. Additionally, little is known about whether the effects of pubertal timing dissipate during adolescence or persist into adulthood and what underlying mechanisms may explain any persisting effects and whether these effects vary by sex. The present study aimed to answer these questions in an understudied population of predominantly African American males and females, focusing on peer deviance and school connectedness as …

Go to article

Examining The Viability Of Native American Stickball As A Comprehensive Indigenous Peace System, Edison Doyle Pearce Jan 2021

Examining The Viability Of Native American Stickball As A Comprehensive Indigenous Peace System, Edison Doyle Pearce

All ETDs from UAB

This study examines the viability of Native American stickball as a comprehensive peace system developed for the primary purpose of ameliorating hostilities, preventing war, and creating a landscape of peace. Originating as early as the 12th century, Native American stickball is recognized as the oldest field sport in North America. More than a game, stickball is steeped in symbolism and comprised of rich oral histories, elements of fictive kinship alliances, religious connotations, and other prosocial mechanisms designed to create and maintain peace. To determine how the interplay between these various components is adaptive through time, a three-phase research model was …

Go to article

An Airway Analysis Of Patients Diagnosed With Juvenile Idiopathic Arthritis Compared To A Control Group, Matt Gibson Jan 2021

An Airway Analysis Of Patients Diagnosed With Juvenile Idiopathic Arthritis Compared To A Control Group, Matt Gibson

All ETDs from UAB

Introduction: The temporomandibular joint (TMJ) is affected in 30-45%% of Juvenile Idiopathic Arthritis (JIA) patients, with all JIA subtypes at risk for TMJ involvement. JIA patients with TMJ involvement may present with altered craniofacial morphology, including micrognathia, mandibular retrognathia, a hyperdivergent mandibular plane angle, and skeletal anterior open bite. These features are also commonly present and associated with non-JIA pediatric patients with obstructive sleep apnea (OSA). Materials and Methods: The study comprised of a group of 32 JIA patients and a group of 32 healthy control subjects. CBCT images were taken for all patients and were imported into Dolphin Imaging …

Go to article

Risk Of Coronary Heart Disease In Blood Of Marrow Transplant Survivors, Radhika Gangaraju Jan 2021

Risk Of Coronary Heart Disease In Blood Of Marrow Transplant Survivors, Radhika Gangaraju

All ETDs from UAB

Background: Blood or marrow transplant (BMT) recipients are vulnerable to accelerated atherosclerosis due to prior exposure to chemotherapy and radiation, and consequent long-term cardiovascular morbidity, such as coronary heart disease (CHD). A comprehensive evaluation of the risk of late-occurring CHD in adult BMT survivors and the associated risk factors has not been performed. Patients and Methods: Using the Blood or Marrow Transplant Survivor Study (BMTSS), we analyzed the incidence and risk factors for CHD in patients who underwent BMT between 1974 and 2014, and survived ≥2 years. The risk of CHD was examined in BMT survivors as compared to 1,131 …

Go to article

First Prev Next Last