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Articles 29281 - 29310 of 36199
Full-Text Articles in Entire DC Network
Numerical And Experimental Study Of Three Imaging Advancements In Phase Contrast Magnetic Resonance Imaging, Longchuan Li
Numerical And Experimental Study Of Three Imaging Advancements In Phase Contrast Magnetic Resonance Imaging, Longchuan Li
All ETDs from UAB
This study aimed at the numerical simulation of three imaging options in phase contrast magnetic resonance (PC-MR), developed jointly at University of Alabama at Birmingham and Allegheny Research Institute. The three methods were: 1) Fragmented Regional Interpolation Segmentation for K-space (FRISK); 2) Enhanced Temporal Resolution (ETR) technique; and 3) Self Reference (SR) PC-MR. The three methods were tested on various physiologic platforms and the data accuracy and acquisition time savings processed by these methods were directly compared to those processed by conventional (CON) PC-MR. Computational fluid dynamics (CFD) data of: a) two-chamber orifice flow model simulating valvular regurgitation, b) a …
Joining Of Aluminum And Long Fiber Thermoplastic (Lft) Composites, Rahul R. Kulkarni
Joining Of Aluminum And Long Fiber Thermoplastic (Lft) Composites, Rahul R. Kulkarni
All ETDs from UAB
Metal/polymer joints are used in variety of areas: aerospace, automotive, prosthetic devices, electronic packaging, etc. The present study involves a tailcone, which is currently made of aluminum and a new design will involve a joint between aluminum and long fiber thermoplastic (LFT) composite. The new tailcones were processed by insert molding, also called as extrusion-compression molding. Finite element (FE) models were used to obtain a temperature profile during cooling of tailcone from processing and to estimate thermal stresses generated. Experimental verification of the temperature profile was obtained by IR thermography. It was observed that the LFT part of the tailcone …
A Model Transformation Approach To Automated Model Evolution, Yuehua Lin
A Model Transformation Approach To Automated Model Evolution, Yuehua Lin
All ETDs from UAB
It is well-known that the inherent complex nature of software systems adds to the challenges of software development. The most notable techniques for addressing the complexity of software development are based on the principles of abstraction, problem decomposition, separation of concerns and automation. As an emerging paradigm for developing complex software, Model-Driven Engineering (MDE) realizes these principles by raising the specification of software to models, which are at a higher level of abstraction than source code. As models are elevated to first-class artifacts within the software development lifecycle, there is an increasing need for frequent model evolution to explore design …
Teaching Reading Using Informational Texts In Third Grade Classrooms: A Case Study In An Urban School District, Dimple J. Martin
Teaching Reading Using Informational Texts In Third Grade Classrooms: A Case Study In An Urban School District, Dimple J. Martin
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The purpose of these multiple descriptive case studies was to describe and analyze the perspectives of three third grade classroom teachers and two third grade reading coaches regarding the use of informational texts and their influence on reading instruction. The research design involved interviews, and observations using a sample composed of three third grade classroom teachers and two third grade reading coaches in five urban, public elementary schools in the Southeastern United States. The aim of this research was to portray a vivid description of the reading episodes in third grade classrooms. The key findings from the study were that …
Kainate Receptor Modulation Of Synaptic Transmission In Neocortex, Seena S. Mathew
Kainate Receptor Modulation Of Synaptic Transmission In Neocortex, Seena S. Mathew
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The actions of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) are tightly regulated to ensure effective information processing as well as prevention of excess excitatory activity, which can lead to seizures and neurological disorders such as epilepsy. Drugs which enhance the effects of GABA are used as anesthetics, sedatives and anticonvulsants. Using whole-cell patch clamp recordings from neocortical neurons, we examined the mechanisms of GABAergic modulation that occur when kainate receptors (KARs) are activated. First, we address a novel signaling mechanism for the KAR-mediated facilitation of GABAergic synaptic transmission. Our first observation involved the presence of presynaptic KARs located on the …
Primer Selection Of E. Coli Trna Lys,3 By Human Immunodeficiency Virus Type-1, Anna Mcculley
Primer Selection Of E. Coli Trna Lys,3 By Human Immunodeficiency Virus Type-1, Anna Mcculley
All ETDs from UAB
Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS). HIV replication includes the notable process of reverse transcription, a conversion of RNA to DNA. Reverse transcription is initiated from a primer by a viral enzyme, reverse transcriptase. The primer, tRNALys,3, is selected from the cytoplasm of an infected cell, annealed via the 3’ terminal 18-nucleotides to the viral primer binding site (PBS), and used in a subsequent infection. The mechanism of primer selection has not been determined although numerous studies have been performed. This has been hampered by the challenge of tRNALys,3 manipulation in the cell and …
Sperm Production And Vitellogenesis As Biomarkers Of Endocrine Disruption In The Male Western Mosquitofish, Gambusia Affinis, Paul D. Melvin
Sperm Production And Vitellogenesis As Biomarkers Of Endocrine Disruption In The Male Western Mosquitofish, Gambusia Affinis, Paul D. Melvin
All ETDs from UAB
Estrogenic compounds of anthropogenic origin enter the environment from several different sources, including domestic wastewater and agricultural runoff. Natural estrogens, synthetic estrogens, and estrogen breakdown products have been identified in wastewater treatment plant (WWTP) effluents. These compounds have direct and indirect effects on the endocrine systems of organisms living in the receiving waters. Male mosquitofish (Gambusia affinis) have been suggested as model bioindicator organisms for endocrine disruption by estrogenic compounds for a variety of reasons, including their hardiness, broad environmental tolerances (including temperature, salinity, and dissolved oxygen), widespread geographical distribution, and ease of use in the laboratory. We examined two …
Directing Akt And Gsk3ss: Molecular Insights Into Cell Signaling And Survival, Gordon P. Meares
Directing Akt And Gsk3ss: Molecular Insights Into Cell Signaling And Survival, Gordon P. Meares
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Proper regulation of survival signaling is critical for all organisms. One important signaling cascade involved in the coordinated effort to control signals influencing cell fate is the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) signaling cascade. Following activation by growth factors the PI3K-Akt pathway promotes cell survival and, cell death is facilitated following inhibition of Akt. Many factors influence the function of the Akt-GSK3β signaling dyad, including phosphorylation, protein complex formation and subcellular localization. Previous work had demonstrated that the 90kDa heat shock protein, HSP90, directly binds and stabilizes Akt. Furthermore, several heat shock proteins including HSP90 and HSP105 can …
Mirror, Mirror: A Phenomenological Study Of The Role Of Reflection In Teaching In Elementary School, Amy Ferguson Morgan
Mirror, Mirror: A Phenomenological Study Of The Role Of Reflection In Teaching In Elementary School, Amy Ferguson Morgan
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In this era of increasing accountability in education, teachers are being asked to move away from the role of intuitive guide to being a more deliberate reflective practitioner. The need exists to understand the experience of reflection and its meaning from the perspective of practicing teachers. Existing studies describe an effective teacher as one who reflects upon her/his teaching. However, they do not illuminate the perspective of teachers to assist other teachers in knowing how to reflect effectively. Guided by works of Dewey (1909/1933) and Schon (1983, 1987), this phenomenological study explored the reflective experiences of practicing teachers in order …
Multiple Roles: Benefits Or Strain? An Examination Of The Effects Of Work And Mothering On Health Lifestyle Behaviors For Women Living With Hiv/Aids, Mercy W. Mwaria
Multiple Roles: Benefits Or Strain? An Examination Of The Effects Of Work And Mothering On Health Lifestyle Behaviors For Women Living With Hiv/Aids, Mercy W. Mwaria
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Does occupying multiple roles cause strain or does it lead to health lifestyle practices for women living with HIV/AIDS? Previous research has established a relationship between multiple role occupation and physical and mental wellbeing for women. Health lifestyle modifications for persons living with HIV/AIDS benefit health by slowing down disease progression and enhancing the body’s tolerance to drug therapies. This study extends these findings to a specific population of women living with HIV/AIDS and examines health lifestyle outcomes for this population. Using data from the HIV Cost and Services Utilization Study (HCSUS), the study draws on a subsample of women …
Retinal Pigment Epithelial Cells And The Insulin-Like Growth Factor System In Proliferative Vitreoretinopathy, Sudipto Mukherjee
Retinal Pigment Epithelial Cells And The Insulin-Like Growth Factor System In Proliferative Vitreoretinopathy, Sudipto Mukherjee
All ETDs from UAB
The goal of this study was to determine the influence, if any, of the insulin-like growth factors (IGFs) on retinal pigment epithelial (RPE) cell tractional force generation and the contributions of vitreous insulin-like growth factor binding proteins (IGFBPs) towards control of IGF activity. Another objective was to evaluate RPE cells as a potential source of all six high-affinity IGFBPs and to determine if IGFBP biosynthesis is modulated in concert with phenotype changes and growth factor stimuli known to be present in disease. RPE generate tractional forces in response to IGF-I and -II with IGF-I being the more potent stimulus. Differential …
Delayed Childbearing, Pregnancy Spacing And Impact On Subsequent Pregnancy Outcomes: Missouri Resident Mothers 1978-1997, Sarah K. Nabukera
Delayed Childbearing, Pregnancy Spacing And Impact On Subsequent Pregnancy Outcomes: Missouri Resident Mothers 1978-1997, Sarah K. Nabukera
All ETDs from UAB
Introduction The main objective of the study was to examine reproductive health issues among women delaying initiation of childbearing until age 30 or older. Specifically, it examined pregnancy spacing patterns, relationship between pregnancy spacing and subsequent perinatal outcomes as well as racial differences in spacing and adverse perinatal outcomes. Methods A retrospective cohort study was conducted using the Missouri maternally linked live birth, fetal death and infant death files 1978-1997. The study sample was limited to mothers residing in Missouri during the study period, having first pregnancy at age 20-50 years, as well as a subsequent second pregnancy. Final study …
Qospl: A Quality Of Service-Driven Software Product Line Engineering Framework For Design And Analysis Of Component-Based Distributed Real-Time And Embedded Systems, Shih-Hsi Liu
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Software complexity may be reduced and productivity may be increased by the synergy of Component-Based Software Engineering and Software Product Line En- gineering. The synergistic techniques decrease complexity by uplifting software ar- tifacts to a higher abstraction level, namely the component level, and de¯ning the interfaces, interactions, and contexts of such artifacts for composing software systems. Such synergistic techniques also facilitate productivity increase by promoting feature reusability, leveraging component replacement and o®ering selectivity among prod- uct variants. When applied to Distributed Real-time and Embedded (DRE) systems, however, these technologies must ful¯ll such systems' time-critical missions and nu- merous functional and …
The Function Of Hiv-1 A-Loop On Primer Selection, Na Ni
The Function Of Hiv-1 A-Loop On Primer Selection, Na Ni
All ETDs from UAB
Reverse transcription is the hallmark of retroviruses, such as HIV-1. A cellular tRNA bound to the primer binding site region (PBS) is used for initiation of reverse transcription. HIV-1 specially selects tRNALys3 as primer, although changing the PBS can force HIV-1 to use alternative tRNAs as a primer. However, HIV-1 reverts back to use tRNALys3 following in vitro replication. The A-loop, located upstream of PBS, interacts with the anti-codon of primer tRNA. The inclusion of A-loop modification has been shown to stabilize the utilization of some alternative tRNAs. The studies in this dissertation focus on further defining the role of …
Association Between The Exposure To Aflatoxin And Micronutrient Status Of Hiv Infected Adults In Ghana, Francis Ayodele Obuseh
Association Between The Exposure To Aflatoxin And Micronutrient Status Of Hiv Infected Adults In Ghana, Francis Ayodele Obuseh
All ETDs from UAB
Aflatoxins, found naturally in some foods are toxic metabolites of some Aspergillus species.They constitute the most potent hepatocarcinogens known and are also mutagenic and hepatotoxic. The preponderance of evidence indicates that aflatoxin is the major cause of hepatocellular cancer. In studies conducted in Africa, food-borne aflatoxin exposure is common (Oyelami et al. 1996; Egal et al. 2005). There is a critical need for additional information on health outcomes associated with exposure to aflatoxin in humans, especially in developing countries with a higher degree of malnutrition and likelihood of HIV infections. We sought to test the hypothesis that aflatoxin B1 and …
Temperament, Sensation-Seeking, Sleep Patterns, And Alcohol Use During A Competitive Athletic Season: Predicting Injuries In College Athletes, Zachary H. Osborn
Temperament, Sensation-Seeking, Sleep Patterns, And Alcohol Use During A Competitive Athletic Season: Predicting Injuries In College Athletes, Zachary H. Osborn
All ETDs from UAB
Temperament, sensation-seeking, general personality variables, sleep patterns, and alcohol use have all been shown to be related to injuries in both community-based and athlete samples. However, these variables have not been studied in concert with one another to examine how they might interact to predict injuries. One-hundred and seventy-eight athletes (both football and soccer) completed pre-season alcohol use and sleep pattern questionnaires, as well as personality measures. The results indicated that playing football predicted more total injuries. No other personality, sleep, or alcohol use variables were predictive of injuries or injury related variables. Analyses also indicated that football players suffered …
Regulation Of Vertebrate Gastrulation By Erbb Signaling, Shuyi Nie
Regulation Of Vertebrate Gastrulation By Erbb Signaling, Shuyi Nie
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ErbB receptor tyrosine kinases have long been implicated in cancer formation and progression by regulating cell division, migration, and survival. ErbBs are also essential in multiple processes during invertebrate development; however, their activities during vertebrate embryogenesis are not well understood. For functional characterization of ErbB signaling during vertebrate development, frog model Xenopus laevis was used in our studies. The expression pattern and the general activities of ErbB receptors during early frog development were first analyzed and results shown that ErbBs regulate gastrulation, somite organization and head patterning. As gastrulation is the first major morphogenetic event in vertebrate development, I focused …
Surveying The Chromosomal Supercoiling Levels In Rapidly Growing Wild Type And Gyrase Mutant Strains Of Salmonella Enterica Serovar Typhimurium With Γδ Resolvase-Mediated Recombination Assay, Zhenhua Pang
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A gyrase mutant strain (gyrB652) has severe growth defect at 42°C. The survival at high temperature is dependent on DNA repair proteins. The purified mutant gyrase was assayed for supercoiling acitivity and quinolone-induced DNA cleavage activity. The results suggested that the mutant enzyme is not temperature-sensitive, but has slower kinetics than the wild type gyrase. The DNA supercoiling levels at multiple chromosomal loci in exponential phase cells were monitored with γδ resolvase-mediated recombination assay. The wild type cells showed homogenous supercoiling levels throughout most of the chromosome. But the superhelicity at dif locus was significantly lower than the other loci. …
An Investigation Of The Impact On Student Achievement Of The Mobile Math Initiative In Three High Poverty Schools In A Single School District, Jeanne D. Payne
An Investigation Of The Impact On Student Achievement Of The Mobile Math Initiative In Three High Poverty Schools In A Single School District, Jeanne D. Payne
All ETDs from UAB
Teachers must increase effectiveness of teaching to prepare quantitatively literate students. The study’s purpose was to determine the effectiveness of the Mobile Math Initiative (MMI) in three high poverty schools. Changes in achievement of 89 students over 3 years were examined using the Stanford 10 (SAT 10) Procedures and Problem Solving subtests and the Alabama Reading and Mathematics Test (ARMT) Math subtest. Independent variables were (a) ethnic background, (b) gender, (c) socioeconomic status, (d) level of English proficiency, (e) level of special education needed, and (f) school student attended. Data were analyzed with the SPSS (Version 15.0) software using factorial …
Insulin Dynamics In African Americans And European Americans: Mechanistic Aspects, And Association With Inflammation, Radhika P. Phadke
Insulin Dynamics In African Americans And European Americans: Mechanistic Aspects, And Association With Inflammation, Radhika P. Phadke
All ETDs from UAB
Identification and characterization of ethnic differences in insulin dynamics, insulin sensitivity (SI), and inflammation may shed light on the greater risk for type 2 diabetes in African Americans (AA), relative to European Americans (EA). Ideally, such studies should take into account the potential confounding roles of adiposity, fat distribution, genetic background, and socioeconomic status (SES). The objectives of this study were, 1) to evaluate ethnic differences in insulin dynamics in AA and EA children and adults using robust measures of insulin secretion and clearance; 2) to identify the contributions of genetic admixture and SES to insulin dynamics; 3) to examine …
Genetic And Epigenetic Modulation Of Telomerase Activity In Development And Disease, Sharla Marion Ostein Phipps
Genetic And Epigenetic Modulation Of Telomerase Activity In Development And Disease, Sharla Marion Ostein Phipps
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The end replication problem of linear chromosomes leads to the erosion of telomeric DNA with each cell division. A mechanism to counteract telomeric attrition involves the activity of the specialized ribonucleoprotein telomerase. Expression of the catalytic subunit of telomerase, hTERT, is tightly regulated and this regulation is achieved through both genetic and epigenetic mechanisms. Activators such as c- MYC and SP1 and repressors such as MAD1, Menin, and p53 mediate hTERT transcription. Epigenetic control mediated by DNA methylation and histone modifications such as methylation and acetylation can reversibly and potently regulate telomerase activity. Not only is there synergism between the …
Enterprise Configuration Management In A Service-Oriented Architecture Environment Delivering It Services, Robert E. Raygan
Enterprise Configuration Management In A Service-Oriented Architecture Environment Delivering It Services, Robert E. Raygan
All ETDs from UAB
Information Technology (IT) is a collaboration environment for business and engineering. The past decade has seen a reduction in business understanding of engineering principles because of the lack of trained engineers working in IT, while businesses have become increasingly dependent upon new and complex technologies. These new technologies, often still evolving, are system-of-systems environments and present significant challenges to early implementers. Service-Oriented Architecture (SOA) is one such system-of-systems that pushes the discipline of Software Configuration Management (SCM) beyond traditionally defined bounds. Evolving standards associated with SOA and the nature of SOA contribute to these challenges of governance and management: loose …
Trafficking Of Hantaviral Nucleocapsid Proteins, Harish N. Ramanathan
Trafficking Of Hantaviral Nucleocapsid Proteins, Harish N. Ramanathan
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Hantaviruses are enveloped, negative-sense RNA viruses belonging to genus Hantavirus, within the family Bunyaviridae. Hantaviruses include many serious human pathogens and are classified as Old and New World based on the geographic distribution of rodent reservoirs and their ability to in induce distinct illnesses in humans. Currently there are no reservoirs known for hantaviruses other than the rodents. Human transmission of hantaviruses occurs via inhalation of aerosolized rodent excreta leading to hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Hantavirus genome consists of small (S), medium (M) and large (L) segments that encode nucleocapsid (N) protein, two …
The Role Of Complement In Experimental Autoimmune Uveitis, Russell W. Read
The Role Of Complement In Experimental Autoimmune Uveitis, Russell W. Read
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The complement system has been increasingly implicated in the pathophysiology of autoimmune disease. Complement expression in the normal human eye had not been previously completely defined. We performed immunohistochemical studies for membrane complement proteins in normal human retina to provide a baseline for future studies. We found expression of the anaphylatoxin receptors, CD55, and CD59 in the inner retina and CD46 in a polarized fashion on the retinal pigment epithelium. Previous studies in uveitis have shown activated fragments of complement in human eyes with uveitis and animal models have shown an effect on disease by complement depletion with cobra venom …
Development And Initial Validation Of A Self-Efficacy Scale For Use With Registered Dietitians Working With Overweight Youth, Christopher M. Reinold
Development And Initial Validation Of A Self-Efficacy Scale For Use With Registered Dietitians Working With Overweight Youth, Christopher M. Reinold
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This study developed and validated the Youth-Directed Obesity Counseling Self-efficacy (Y-DOCS) Scale to evaluate the self-efficacy of registered dietitians (RDs) working with childhood overweight. The specific purpose of this study was to create an evaluation instrument that can measure the effectiveness of continuing education (CE) that provides behavioral counseling training. Two research questions guided this investigation into measuring the self-efficacy of RD’s: (a) Is the Y-DOCS scale for dietitians a reliable instrument for assessing self-efficacy among dietitians who receive training? (b) Is the Y-DOCS scale for dietitians a valid instrument for assessing self-efficacy among dietitians who receive training? The population …
Pathogenesis And Therapeutic Potential Of Plasmacytoid Dendritic Cells In Siv/Shiv-Infected Macaques, R Keith Reeves
Pathogenesis And Therapeutic Potential Of Plasmacytoid Dendritic Cells In Siv/Shiv-Infected Macaques, R Keith Reeves
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Plasmacytoid dendritic cells (pDCs) are among the first responders during acute viral infections and are the primary producers of IFN-α, a cytokine known to inhibit viral replication and to activate natural killer (NK) cells. In HIV patients pDCs are decreased in number, are dysfunctional, and can harbor HIV-1 proviruses. However, since the time of transmission is usually unknown, pDC-virus interactions immediately after exposure to HIV remain unclear. Using the SIV/SHIV-macaque model, we showed that an acute and sustained loss of blood pDCs occurred during SIVmac239 infections, and when compared to those from naïve controls, pDCs were also significantly reduced in …
In Vivo Imaging Studies In Animal Models Of Myocardial Infarction With And Without Cell Injections, Balazs Ruzsics
In Vivo Imaging Studies In Animal Models Of Myocardial Infarction With And Without Cell Injections, Balazs Ruzsics
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After prolonged myocardial ischemia, myocardial infarction occurs. Several tissue changes are associated with myocardial infarction and iron labeled cell injections. In the present thesis our major aim was to develop methods to monitor these tissue changes with MRI and MDCT. In the first chapter we used transendocardial injection to deliver iron labeled allogen skeletal myoblasts one week after myocardial infarction. Our goal was to identify the cells and/or injection sites in the myocardium. We used our new Tissue Characterization Mapping method to delineate tissue edema and hemorrhage in the myocardium. The T2 weighted signal intensity enhancement, T2w SIE region was …
Factors Influencing The Adoption Of Administrative Innovations, Tom J. Sanders
Factors Influencing The Adoption Of Administrative Innovations, Tom J. Sanders
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The purpose of this dissertation was to investigate the influence of selected environmental and organizational factors on the adoption of administrative innovations in order to better understand strategic adaptation by organizations. General systems theory, various organizational theories, strategic adaptation and management theories, and adoption and diffusion of innovation literature were used to develop a theoretical framework to address four primary and sixteen secondary hypotheses. The administrative innovation used for this study was the magnet hospital concept for enhancing attraction and retention of registered nurses in order to address a persistent workforce shortage in U.S. hospitals. Secondary data related to U.S. …
Processing, Characterizati On And Modeling Of Carbon Nanofiber Modified Carbo N/Carbon Composites, Francis J. Samalot Rivera
Processing, Characterizati On And Modeling Of Carbon Nanofiber Modified Carbo N/Carbon Composites, Francis J. Samalot Rivera
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Carbon/Carbon (C/C) composites are used in high temperature applications because they exhibit excellent thermomechanical properties. There are several challenges associated with the processing of C/C composites that include long cycle times, formation of closed porosity within fabric woven architecture and carbonization induced cracks that can lead to reduction of mechanical properties. This work addresses various innovative approaches to reduce processing uncertainties and thereby improve thermomechanical properties of C/C by using vapor grown carbon nanofibers (VGCNFs) in conjunction with carbon fabric and precursor phenolic matrix. The different aspects of the proposed research contribute to understanding of the translation of VGCNFs properties …
Caste As A Determinant Of Utilization Of Maternal And Neonatal Healthcare Services In Maitha, Uttar Pradesh, India, Ekta Saroha
Caste As A Determinant Of Utilization Of Maternal And Neonatal Healthcare Services In Maitha, Uttar Pradesh, India, Ekta Saroha
All ETDs from UAB
Caste among Hindus in India is a non-modifiable socio-demographic characteristic, often the basis of segregation and discrimination. Despite the provision of subsidized maternal and child healthcare services, utilization in rural Uttar Pradesh (UP), India is poor. Studies showed that upper caste (UC) women were more likely to utilize healthcare services than the lower caste (LC) women but this association is inadequately researched. We explored whether caste was a determinant of utilization of maternal healthcare (MH) and neonatal healthcare (NH) services among rural Hindu women and neonates in Maitha, UP, India. Data from the ‘Morbidity and Performance Assessment’ study for 482 …