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Mitochondrial Genetics And Cellular Metabolism Regulate Tumorigenicity And Metastatic Potential, Kyle Paul Feeley Jan 2014

Mitochondrial Genetics And Cellular Metabolism Regulate Tumorigenicity And Metastatic Potential, Kyle Paul Feeley

All ETDs from UAB

Current paradigms of carcinogenic risk suggest that genetic, hormonal, and environmental factors combine to influence an individual's predilection for breast cancer and related metastatic tumor formation. The genetic component, in particular, has become the focus of many emergent studies. A renewed focus on cancer metabolism and the Warburg effect has similarly cast a spotlight on the role, if any, of the mitochondrion in directing disease progression. Analysis of the direct contribution of mitochondrial DNA on tumorigenicity is made possible through the use of mitochondrial-nuclear exchange (MNX) mice in which nuclei from normal FVB mice (the background strain of the tg: …


Exploring Novel System Biology Approaches To Understand The Molecular Mechanisms Of Immune Responses, Cassandra Camille Garbutt Jan 2014

Exploring Novel System Biology Approaches To Understand The Molecular Mechanisms Of Immune Responses, Cassandra Camille Garbutt

All ETDs from UAB

nesting behavior on sex ratios and survival of eggs and hatchlings. The results indicate


The Role Of Human Ficolin-2 During Invasive Pneumococcal Disease, Allison Marie Brady Jan 2014

The Role Of Human Ficolin-2 During Invasive Pneumococcal Disease, Allison Marie Brady

All ETDs from UAB

Streptococcus pneumoniae (pneumococcus) is a significant human pathogen that typically resides in the nasopharynx of humans. The major virulence factor of pneumococcus is its capsular polysaccharide, of which it can express over 90 unique serotypes. However, there is great disparity in which serotypes colonize or cause disease, though the reason for these differences are not well understood. Serotype 11A is one such serotype that frequently colonizes the nasopharynx of children, but rarely causes disease. Interestingly, serotype 11E, a variant of 11A, varies only in the O-acetylation of a galactose residue in its polysaccharide repeating unit. This difference in structure is …


The Role Of The Developing Microbiome In Mucosal Defense Of The Neonatal Gut, Emily G. Blosser Jan 2014

The Role Of The Developing Microbiome In Mucosal Defense Of The Neonatal Gut, Emily G. Blosser

All ETDs from UAB

Neonatal late-onset sepsis is invasive infection occurring after the first 48 hours of life, and one of the leading causes of death among preterm infants in the United States and abroad. Infections with Gram-negative bacteria, such as Klebsiella pneumonia, occurring when bacteria translocate across premature gut epithelium into the bloodstream, can be particularly severe. Preterm infants in the neonatal intensive care unit undergo intense antibiotic regimens due to high risk of infection. Paradoxically, prolonged exposure of preterm infants to empiric antibiotic therapy early in the hospital stay is associated with increased risk of intestinal infection and death after adjustment for …


A Mixed Methods Study Of Health Literacy And Its Role In Hpv Vaccine Uptake Among College Students, Michelle Sharonda Williams Jan 2014

A Mixed Methods Study Of Health Literacy And Its Role In Hpv Vaccine Uptake Among College Students, Michelle Sharonda Williams

All ETDs from UAB

Health literacy includes the ability to understand and process written and spoken health information, and numbers and calculations related to health information. Low health literacy is associated with negative health outcomes, and poor patient-provider communication. In order to advance health literacy research, there is a need to assess health literacy comprehensively and to develop an understanding of how health literacy impacts people at various stages of their lives. A sequential explanatory mixed methods study was conducted to assess college students' health literacy. During the quantitative phase, the Short Test of Functional Health Literacy in Adults (S-TOFHLA), the Newest Vital Sign …


The Multifaceted Role Of Neutrophils In Hiv-1-Infection, Nathan Bowers Jan 2014

The Multifaceted Role Of Neutrophils In Hiv-1-Infection, Nathan Bowers

All ETDs from UAB

In recent years, a new appreciation of the role of neutrophils in regulating the immune system has emerged. Neutrophils are the most abundant leukocyte population and are traditionally recognized as essential effector cells of the innate immune system in the host defense against invading organisms. Neutrophils play a critical role in controlling bacterial and fungal infections by multiple mechanisms including phagocytosis, degranulation, and formation of neutrophil extracellular traps (NETs). Neutrophils have been shown to play important roles in viral pathogenesis, a knowledge gap exists in our understanding of the function of neutrophils in individuals infected with human immunodeficiency virus-1 (HIV-1). …


Newly Identified Immune Receptor May Activate B Cells In Autoimmunity, Greg Williams Dec 2013

Newly Identified Immune Receptor May Activate B Cells In Autoimmunity, Greg Williams

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No abstract provided.


Newly Identified Immune Receptor May Activate B Cells In Autoimmunity, Jim Bakken Dec 2013

Newly Identified Immune Receptor May Activate B Cells In Autoimmunity, Jim Bakken

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No abstract provided.


Faculty Become Students To Learn Simulation Training, Clinton Colmenares Dec 2013

Faculty Become Students To Learn Simulation Training, Clinton Colmenares

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No abstract provided.


Geisler Takes Leadership Role In Physician-Scientist Training, Kendra Carter Dec 2013

Geisler Takes Leadership Role In Physician-Scientist Training, Kendra Carter

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No abstract provided.


December 6, 2013 Ereporter, University Of Alabama At Birmingham Dec 2013

December 6, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Uab Commencement Scheduled For Dec. 14, Staff Dec 2013

Uab Commencement Scheduled For Dec. 14, Staff

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No abstract provided.


October 18, 2013 Ereporter, University Of Alabama At Birmingham Oct 2013

October 18, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Infection Blocks Trash Removal To Cause Ulcers, Cancer, Greg Williams Sep 2013

Infection Blocks Trash Removal To Cause Ulcers, Cancer, Greg Williams

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No abstract provided.


Hiv Expertise Helps To Fight Rise Of Hepatitis C, Uab Medicine Magazine Aug 2013

Hiv Expertise Helps To Fight Rise Of Hepatitis C, Uab Medicine Magazine

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No abstract provided.


August 23, 2013 Ereporter, University Of Alabama At Birmingham Aug 2013

August 23, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Schwebke Receives Award For Achievement In Std Research, Reporter Staff Aug 2013

Schwebke Receives Award For Achievement In Std Research, Reporter Staff

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No abstract provided.


Schwebke Receives Award For Achievement In Std Research, Jim Bakken Aug 2013

Schwebke Receives Award For Achievement In Std Research, Jim Bakken

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No abstract provided.


Social Causes Of Diseases Receive Grant Support, Clinton Colmenares Aug 2013

Social Causes Of Diseases Receive Grant Support, Clinton Colmenares

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No abstract provided.


Goepfert To Chair National Study Section, Reporter Staff Jul 2013

Goepfert To Chair National Study Section, Reporter Staff

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No abstract provided.


Whitley Serving On Nih Committee, Reporter Staff Jul 2013

Whitley Serving On Nih Committee, Reporter Staff

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No abstract provided.


Uab School Of Dentistry Operates Only Retirement Community Dental Clinic In State, Jim Bakken Jul 2013

Uab School Of Dentistry Operates Only Retirement Community Dental Clinic In State, Jim Bakken

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No abstract provided.


Is A Common Food Fungus Worsening The Aids Epidemic?, Jim Bakken Jul 2013

Is A Common Food Fungus Worsening The Aids Epidemic?, Jim Bakken

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No abstract provided.


Is A Common Food Fungus Worsening The Aids Epidemic?, Reporter Staff Jul 2013

Is A Common Food Fungus Worsening The Aids Epidemic?, Reporter Staff

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No abstract provided.


Endowed Support Fund In Infectious Diseases Established, Jim Bakken Jun 2013

Endowed Support Fund In Infectious Diseases Established, Jim Bakken

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No abstract provided.


Immune Defenses Amplify Parkinson's Disease Damage, Greg Williams Jun 2013

Immune Defenses Amplify Parkinson's Disease Damage, Greg Williams

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No abstract provided.


Improving Veteran Care Through Research, Clinton Colmenares May 2013

Improving Veteran Care Through Research, Clinton Colmenares

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No abstract provided.


Engage To Inspire, Anupam Agarwal Md Apr 2013

Engage To Inspire, Anupam Agarwal Md

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No abstract provided.


March 15, 2013 Ereporter, University Of Alabama At Birmingham Mar 2013

March 15, 2013 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Primary Care Ranks In Top 10 By U.S. News & World Report, Uab Heersink School Of Medicine News Mar 2013

Primary Care Ranks In Top 10 By U.S. News & World Report, Uab Heersink School Of Medicine News

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No abstract provided.