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Articles 781 - 810 of 1601
Full-Text Articles in Entire DC Network
Uab Schools Again Ranked In Top 10 By U.S. News & World Report, Jim Bakken
Uab Schools Again Ranked In Top 10 By U.S. News & World Report, Jim Bakken
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No abstract provided.
New Opportunities Arise For Research Travel To Africa, Greg Williams
New Opportunities Arise For Research Travel To Africa, Greg Williams
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No abstract provided.
New Opportunities Arise For Uab Research Travel To Africa, Jim Bakken
New Opportunities Arise For Uab Research Travel To Africa, Jim Bakken
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No abstract provided.
Anupam Agarwal Chosen As Interim Dean, Senior Vp Of Uab School Of Medicine, Jim Bakken
Anupam Agarwal Chosen As Interim Dean, Senior Vp Of Uab School Of Medicine, Jim Bakken
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No abstract provided.
Microbiology's Mestecky Leads This Years Honorees For Service Awards Recognition, Tyler Greer
Microbiology's Mestecky Leads This Years Honorees For Service Awards Recognition, Tyler Greer
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No abstract provided.
Uab Awards $1.4 Million In Research Grants To Faculty, Jim Bakken
Uab Awards $1.4 Million In Research Grants To Faculty, Jim Bakken
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No abstract provided.
Inquiro 7 (Complete Issue), Inquiro Staff
Inquiro 7 (Complete Issue), Inquiro Staff
Inquiro (undergraduate research journal)
No abstract provided.
The Last Stand: A Synthetic Compound Treatment For Tuberculosis, Harsh Shah
The Last Stand: A Synthetic Compound Treatment For Tuberculosis, Harsh Shah
Inquiro (undergraduate research journal)
pp. 9-10
Science Vs. Pseudoscience, Grace Nix
Straight Through The Middle: Notes From My Journey, Nancy Rutland Glaub
Straight Through The Middle: Notes From My Journey, Nancy Rutland Glaub
All ETDs from UAB
This memoir is primarily a collection of creative nonfiction essays. It includes one fictional short story for adults, "Rise," and one fictional story written for children, "The Memory Keepers." The essays and stories were produced following the death of my son; they explore the process of grieving his loss and rediscovering purpose and meaning in my life through story, faith, and community.
Identification Of Staphylococcus Aureus Sortase A Inhibitors As Potential Antibacterial Agents, Bala Chandra Chenna
Identification Of Staphylococcus Aureus Sortase A Inhibitors As Potential Antibacterial Agents, Bala Chandra Chenna
All ETDs from UAB
Staphylococcus aureus (S. aureus) is the causative organism for a wide range of infectious diseases from superficial skin infections to dangerous bacteremias. Six pathogens named ESKAPE pathogens are responsible for majority of antibiotic resistant bacterial infections. MRSA is the single most prevalent ESKAPE pathogen. Many of the nosocomial MRSA strains are multi-drug resistant, and even methicillin-sensitive strains can be deadly. S. aureus has recently taken on a new role in causing an escalating number of community-acquired infections in non-hospitalized persons without predisposing risk factors. Due to the increase in the number of infections caused by multi-drug resistant S. aureus and …
Selection And Evolution Of Pneumococci In Response To Conjugate Vaccines, Christina M. Croney
Selection And Evolution Of Pneumococci In Response To Conjugate Vaccines, Christina M. Croney
All ETDs from UAB
Pneumococcal conjugate vaccines (PCVs) containing subsets of the >90 capsular polysaccharide antigens have been successful as a means of decreasing invasive and non-invasive pneumococcal disease worldwide. However, this success is limited to the specif-ic capsular serotypes against which PCVs are formulated and studies have reported the increase of nonvaccine serotypes. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the United States in 2010 for the prevention of invasive pneumococcal disease (IPD) and otitis media and was released without efficacy data. In this study we set out to 1) determine potential efficacy for invasive and noninvasive pneumococcal disease and 2) …
Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo
Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo
All ETDs from UAB
Mutations in the AP3-ß1 gene are known to cause Hermansky-Pudlak syndrome type 2 (HPS2) in humans and canine cyclic hematopoiesis (CH) in gray collie dogs. HPS2 patients have severe congenital neutropenia (SCN), and dogs have cyclic neutropenia (CN). The mechanism behind neutropenia is uncertain. Pearl mice have an AP3-ß1 mutation, but whether they actually have neutropenia has not yet been evaluated. This dissertation presents a discussion of the evaluation of neutropenia in pearl mice, hematopoietic progenitor cell mobilization defect in pearl mice and finally an evaluation of methods of dog-to-mouse xenotransplantation to establish a xenotransplant model of the dog hematopoietic …
Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston
Potential Roles Of The Immunostimulatory Signals Il-15 And Mica In Oncolytic Hsv-1 Therapy For Malignant Glioma, David Curtis Gaston
All ETDs from UAB
Malignant gliomas are the most frequently diagnosed and the most fatal primary brain tumors. Innovative therapeutic approaches are necessary to combat these devastating cancers, and oncolytic herpes simplex virus type-1 (oHSV) deleted of the γ134.5 neurovirulence gene is a promising adjunctive therapy. The primary mechanism of tumor clearance by oHSV is lytic replication specifically within malignant cells. oHSV also stimulates tumor infiltration of cytotoxic immune effector cells that can participate in tumor clearance. However, cytotoxic immune cells target oHSV as well as tumor, which may limit therapeutic efficacy. Further knowledge regarding the nature of these interactions and how the interactions …
The Flow Of The Social: Developing A Constructal Systemic Approach To The Study Of Health Inequalities, William A. Anderson
The Flow Of The Social: Developing A Constructal Systemic Approach To The Study Of Health Inequalities, William A. Anderson
All ETDs from UAB
Society is a dynamic, living system. People, groups, institutions, and cultures are intricately interconnected. Changes in one area of society create changes in other areas. Causes and results may be closely linked or separated by time and space. Sociologists readily acknowledge this dynamic reality. However, our mainstream theories and methods often fail to account for it. Even after decades of research into social inequalities in health, medical sociology still seems far away from being able to offer any definitive ideas about why such inequalities exist and persist despite efforts to alleviate them. Medical sociology (and sociology in general) is centered …
Energy Performance Evaluation Of Aac, Hulya Aybek
Energy Performance Evaluation Of Aac, Hulya Aybek
All ETDs from UAB
The U.S. building industry constitutes the largest consumer of energy (i.e., electricity, natural gas, petroleum) in the world. The building sector uses almost 41percent of the primary energy and approximately 72percent of the available electricity in the United States. As global energy-generating resources are being depleted at exponential rates, the amount of energy consumed and wasted cannot be ignored. Professionals concerned about the environment have placed a high priority on finding solutions that reduce energy consumption while maintaining occupant comfort. Sustainable design and the judicious combination of building materials comprise one solution to this problem. A future including sustainable energy …
Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty
Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty
All ETDs from UAB
Adenoviruses are the most commonly used gene therapy vector for cancer therapy clinical trials. While adenovirus has shown a great track record in a variety of cancer therapeutics it has not progressed as a vector system for the modification of T lymphocytes. One of the major roadblocks towards utilizing adenovirus for T cell therapy is the lack of coxsackie virus and adenovirus receptor on the cell surface of T cell lineages. Exploitation of alternative receptors has allowed adenovirus vectors to be utilized in a variety of cell types that native adenovirus type 5 cannot infect. Thus, retargeting adenovirus to an …
Environmental Specific Effects On Life History And Energy Metabolism Traits In A Permethrin Resistant Strain Of Anopheles Gambiae, Dennis Otali
All ETDs from UAB
Widespread use of pyrethroids for control of malaria vectors together with use in agriculture for pest control has led to an increase in emergence of populations of pyrethroid resistant phenotypes. Insecticide resistance can likely alter vector development time, reproduction, behavior, and longevity, all of which can affect the potential for disease transmission. In this study we assessed whether the genetic modifications (kdr mutation, cytochrome P450 and esterase detoxification) in a permethrin resistant strain of An. gambiae influence traits related to fitness. The performances of these traits were compared between two strains of An. gambiae, one permethrin susceptible (ASEMBO1) and the …
Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga
Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga
All ETDs from UAB
This dissertation research focuses on how variants in various host genes are associated with clearance of HPV in three longitudinal cohorts from the United States. I first examined the definition of the intermediate phenotype to cervical cancer, HPV persistence and then I incorporated this phenotype in all my three aims by examining variations in xenobiotic metabolism genes in HIV-1 negative and immune-related genes in HIV-1 positive females and how these contribute to HPV infection outcomes. Several significant variants were associated with HPV clearance for the three aims. For the first aim, in ALTS assessing functional variants within xenobiotic metabolism genes …
Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James
Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James
All ETDs from UAB
Human Immunodeficiency Virus (HIV) is one of the leading infectious diseases in the world. In spite of substantial progress in the advancement of antiretroviral therapy for HIV treatment, new infections outpace the number of infected persons initiating ART. Therefore, the prevention of HIV remains a crucial health issue. Pre-Exposure Prophylaxis, (PrEP), which involves using one or more antiretroviral agents to reduce the risk of HIV infection prior to potential exposure, has shown effectiveness at reducing HIV transmission in study volunteers with different sexual orientation around the world. The clinical pharmacology of antiretroviral drugs, specifically tenofovir (TFV) and emtricitabine (FTC), in …
Use Of Social Ecology And Mixed Methods Research To Develop An Instrument To Assess Determinants Of Hiv/Sti Risk Among A Young Adult Population, Lasonja Bonita Kennedy
Use Of Social Ecology And Mixed Methods Research To Develop An Instrument To Assess Determinants Of Hiv/Sti Risk Among A Young Adult Population, Lasonja Bonita Kennedy
All ETDs from UAB
Globally, 340 million people are affected by HIV/AIDS. Approximately 50,000 are newly infected within the United States each year with HIV. One in five of those infected is unaware of his/her status. Young adults are particularly impacted by the disease; 39% of new HIV infections are diagnosed in individuals between the ages of 13 and 29. To comprehensively examine the independent and interrelated determinants of HIV/STI risks among young adults, the researcher developed, validated, and psychometrically examined a self-report instrument guided by constructs from the Social Ecological Model (SEM). Development and validation of the content within the survey was conducted …
The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos
The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos
All ETDs from UAB
Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30%, and 10% of CM survivors have permanent neurological sequelae. Since inflammation is a central pathophysiological tenet of CM, we began examining the role of the complement system in pathogenesis of experimental cerebral malaria (ECM) using Plasmodium berghei ANKA (PbA) model. Previous studies using this model indicated that mice naturally deficient in complement component C5 were protected from cerebral complications, and wild type mice treated with anti-C5aR antibody were also protected. To determine the protective mechanism of naturally-C5 deficient mice, …
Tuberculosis Screening And Treatment Outcomes In Zambia, Jennifer Harris
Tuberculosis Screening And Treatment Outcomes In Zambia, Jennifer Harris
All ETDs from UAB
Zambia is a country in Southern Africa with dual HIV and tuberculosis (TB) epidemics. The annual TB incidence is 444/100,000 and 64% of TB patients are co-infected with HIV. Accurate screening and diagnosis for TB is challenging since it often presents with non-specific signs and symptoms and the available diagnostics are neither sensitive nor specific. Papers one and two of this dissertation focus on the derivation of TB screening rules to more accurately identify high-risk persons in two Zambian populations: inmates and HIV clinic patients. Among inmates, being HIV positive and having a body mass index < 18.5 most strongly predicted HIV disease. Chest pain was also strongly associated, but this may have been a chance finding. For HIV clinic patients, we developed four rules with increasing complexity of clinical tools used for screening. Sensitivity was very high with all rules; the addition of vital signs and pulmonary exam findings to symptom-based screening rules greatly increased the rules' specificity. Furthermore, a rule incorporating pulmonary exam findings performed similarly to a rule with chest radiography suggesting pulmonary exam may be an inexpensive alternative to x-ray. The final paper looks at TB incidence, mortality and intermediate clinical outcomes in a cohort of HIV clinic patients with and without TB during their first 12 months of HIV care. TB incidence was very high during this time period, despite thorough screening at baseline. Mortality was elevated in both culture-confirmed and clinically-diagnosed TB patients, with much of the elevated risk concentrated in TB patients who had culture-confirmed but clinically-unapparent disease. Looking at intermediate outcomes among patients who started anti-retroviral therapy, the change in CD4 cell count was similar for patients with and without TB. TB patients started off with lower mean body weights and hemoglobin concentrations but also showed greater increases over 12 months, thus `catching up' with the TB-negative patients. If these findings are replicable in other cohorts they could have substantial impact on TB screening and diagnostic procedures in resource limited, high burden countries like Zambia.
Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah
Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah
All ETDs from UAB
Fc receptors provide an interface between humoral immunity and cellular immunity by binding to the Fc portion of immunoglobulin and mediating effector functions. Cells expressing Fc receptors play a major role in immune complex clearance via phagocytosis, leading to a context dependent pro- or anti-inflammatory environment. Signaling by multi-chain Fc receptor complexes, including FcgRI, FcgRIII, FceRI and FcaRI is mediated by the ITAM-containing common FceRIg (g-chain) subunit. However, despite the use of a common g-chain, different Fc receptor complexes elicit specific cellular programs, suggesting additional layers of regulation of tyrosine based signaling by g-chain. We hypothesized that the unique g-chain …
Research Team Sets Sights On New Era In Neuroprotection, Greg Williams
Research Team Sets Sights On New Era In Neuroprotection, Greg Williams
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No abstract provided.
September 7, 2012 Ereporter, University Of Alabama At Birmingham
September 7, 2012 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
With No West Nile Vaccine In Sight, Self-Protection Is Key, Jim Bakken
With No West Nile Vaccine In Sight, Self-Protection Is Key, Jim Bakken
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No abstract provided.
August 31, 2012 Ereporter, University Of Alabama At Birmingham
August 31, 2012 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Whitley Receives Inaugural Nih Award, Jim Bakken
Whitley Receives Inaugural Nih Award, Jim Bakken
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No abstract provided.
Uab Award Honors Achievement In Statistical Sciences, Staff
Uab Award Honors Achievement In Statistical Sciences, Staff
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No abstract provided.