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Protect Yourself Against Infectious Disease, Here And Abroad, Traci Bratton Aug 2014

Protect Yourself Against Infectious Disease, Here And Abroad, Traci Bratton

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No abstract provided.


Missed Clinic Visits Predictor Of Mortality In Hiv, Staff Aug 2014

Missed Clinic Visits Predictor Of Mortality In Hiv, Staff

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No abstract provided.


10 Essential Facts About Ebola, Staff Aug 2014

10 Essential Facts About Ebola, Staff

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No abstract provided.


Reminder For Adults: Immunizations Are Still Needed And Can Be Lifesaving, Jim Bakken Jul 2014

Reminder For Adults: Immunizations Are Still Needed And Can Be Lifesaving, Jim Bakken

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No abstract provided.


Pappas Among First Academics To Conduct Clinical Research At Nih, Uab Heersink School Of Medicine News Apr 2014

Pappas Among First Academics To Conduct Clinical Research At Nih, Uab Heersink School Of Medicine News

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No abstract provided.


April 29, 2014 Ereporter, University Of Alabama At Birmingham Apr 2014

April 29, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Pappas Among First Academics To Conduct Clinical Research At Nih, Reporter Staff Apr 2014

Pappas Among First Academics To Conduct Clinical Research At Nih, Reporter Staff

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No abstract provided.


Uab's Saag To Be Recognized Nationally For Efforts To Combat Hiv/Aids, Jim Bakken Mar 2014

Uab's Saag To Be Recognized Nationally For Efforts To Combat Hiv/Aids, Jim Bakken

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No abstract provided.


Effects Of Hiv May Impact Driving Abilities Of Middle-Age And Older Adults, Tyler Greer Mar 2014

Effects Of Hiv May Impact Driving Abilities Of Middle-Age And Older Adults, Tyler Greer

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No abstract provided.


Renowned Hiv Pioneer Writes Book About Treating Aids Since Its Beginning, And The "Dysfunctional" U.S. Health Care System, Jim Bakken Feb 2014

Renowned Hiv Pioneer Writes Book About Treating Aids Since Its Beginning, And The "Dysfunctional" U.S. Health Care System, Jim Bakken

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No abstract provided.


Shealy Among Six Honored For 40 Years Of Service To Uab, Natalie Wade Feb 2014

Shealy Among Six Honored For 40 Years Of Service To Uab, Natalie Wade

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No abstract provided.


February 18, 2014 Ereporter, University Of Alabama At Birmingham Feb 2014

February 18, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


February 11, 2014 Ereporter, University Of Alabama At Birmingham Feb 2014

February 11, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


New 'Living Document' Provides Real-Time Hepatitis C Treatment Guidance, Jim Bakken Feb 2014

New 'Living Document' Provides Real-Time Hepatitis C Treatment Guidance, Jim Bakken

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No abstract provided.


Uab Study Describes Continued Inappropriate Antibiotic Use In Ers, Alicia Rohan Jan 2014

Uab Study Describes Continued Inappropriate Antibiotic Use In Ers, Alicia Rohan

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No abstract provided.


January 14, 2014 Ereporter, University Of Alabama At Birmingham Jan 2014

January 14, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Uab Magazine - Fall 2014, University Of Alabama At Birmingham Jan 2014

Uab Magazine - Fall 2014, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.


Isolation And Characterization Of Ltdan, A Novel Phage Infecting Acinetobacter Guillouiae, Emil Kurian, Jessica Maya, Katrina Sahawneh, Sarah Swalley, Edwin Tsay, Beth Tuttle, Neha Udayakumar, Justin Wimberly, Tiffany Colburn, Jordan Gallardo, Alex Johnson, Sean Mcmahon, Brenna Nye, Brooke Pruitt, Surabhi Rao, Sarahanne Davidson, Denise Monti Jan 2014

Isolation And Characterization Of Ltdan, A Novel Phage Infecting Acinetobacter Guillouiae, Emil Kurian, Jessica Maya, Katrina Sahawneh, Sarah Swalley, Edwin Tsay, Beth Tuttle, Neha Udayakumar, Justin Wimberly, Tiffany Colburn, Jordan Gallardo, Alex Johnson, Sean Mcmahon, Brenna Nye, Brooke Pruitt, Surabhi Rao, Sarahanne Davidson, Denise Monti

Inquiro (undergraduate research journal)

pp. 27-31


Detection Of Scardovia Genus From Oral Samples In Children Using Real-Time Quantitative Polymerase Chain Reaction, Jungyi Alexis Liu Jan 2014

Detection Of Scardovia Genus From Oral Samples In Children Using Real-Time Quantitative Polymerase Chain Reaction, Jungyi Alexis Liu

All ETDs from UAB

Streptococcus mutans (Sm) and Streptococcus sobrinus (Ss) , are considered the major bacterium associated with dental caries. However, recent findings identify Scardovia species (Sc) is associated with early childhood caries, with or without the presence of Sm or Ss. This IRB approved study quantified the presence of Sm and Sc in saliva by real-time quantitative PCR (qPCR) in relation to caries. Saliva samples were collected from 72 preschool children in a high-caries risk community in rural Alabama. SYBR Green-based qPCR using extracted DNA and primers specific for Sm, Ss, Sc and total bacteria determined the copy number (CN/ml). Twenty two …


Ecology And Physiology Of Antarctic Macrophytes Under The Influence Of Abiotic And Biotic Stressors., Kathryn M. Schoenrock Jan 2014

Ecology And Physiology Of Antarctic Macrophytes Under The Influence Of Abiotic And Biotic Stressors., Kathryn M. Schoenrock

All ETDs from UAB

The physiology of many species of Antarctic marine algae was evaluated under a variety of biotic and abiotic factors found or predicted for the western Antarctic Peninsula. The potential biological stressors, filamentous algal endophytes, had few effects on their macrophyte host's physiology which may be the cause for their persistence in this marine community. Adversely impacted hosts include Pachymenia sp. and Iridaea cordata. In areas of high endophyte infection Pachymenia sp. was significantly less resistant to forces that could penetrate their thalli. Maximum quantum yield near endophyte infection was significantly lower in I. cordata. Endophyte abundance is significantly lower in …


Urbanization And Land-Use Change In Puerto Maldonado, Peru: Categorizing The Landscape Using High-Resolution Satellite Imagery For Potential Use In Public Health Research, Laura Brianna Gast Jan 2014

Urbanization And Land-Use Change In Puerto Maldonado, Peru: Categorizing The Landscape Using High-Resolution Satellite Imagery For Potential Use In Public Health Research, Laura Brianna Gast

All ETDs from UAB

Environmental change, especially rapid urbanization, has measurable effects on human health. Over 70 percent of the global population is expected to live in urban areas by 2025, and at least 1 in 3 of these individuals will live in extreme poverty. Living in a slum or shantytown exposes individuals to health and safety risks including inadequate sanitation, lack of access to clean water, air pollution, violence, over-crowding and risk of infectious disease. Remote sensing technologies are an effective tool for detection and prediction of areas with significant land use change, which enables identification of populations with the highest risk of …


A Spatiotemporal Model For Repeated Imaging Data, Brandon George Jan 2014

A Spatiotemporal Model For Repeated Imaging Data, Brandon George

All ETDs from UAB

Longitudinal imaging studies have increased in popularity as clinical researchers seek to investigate how phenomena within the body change over time. Analysis of data from these studies is complicated by correlation between repeated measures over time and different locations in the body. To address this problem we propose the use of a linear model with a separable parametric correlation structure. This model considers spatial and temporal correlation independently and incorporates the correlation using parametric functions that have the potential to be much more efficient than an unstructured approach. Our model also has the ability to control for time- and space-varying …


Development And Testing Of The Primary Care Homeless Organizational Assessment Tool (Pc-Hoat) To Evaluate Primary Care Services For The Homeless, Jocelyn Louise Steward Jan 2014

Development And Testing Of The Primary Care Homeless Organizational Assessment Tool (Pc-Hoat) To Evaluate Primary Care Services For The Homeless, Jocelyn Louise Steward

All ETDs from UAB

The purpose of this dissertation is to develop and test an organizational assessment tool that can used to evaluate primary care services for the homeless. The research evaluates the importance, feasibility, reliability, and validity of organizational processes and structures of primary care services for the homeless. The final product is the validated Primary Care Homeless Organizational Assessment Tool (PC-HOAT). This tool provides stakeholders with information regarding the organizational structures and processes associated with greater quality of primary care for the homeless. This tool will help managers better understand their organization's strengths and weaknesses, guide discussions regarding operations, and provide information …


Hormonal Contraceptives Alter The Immune Function And Structural Integrity Of The Female Genital Tract: Implications For Hiv-1 Infection, Katherine Gisella Michel Jan 2014

Hormonal Contraceptives Alter The Immune Function And Structural Integrity Of The Female Genital Tract: Implications For Hiv-1 Infection, Katherine Gisella Michel

All ETDs from UAB

The potential effect of hormonal contraception on HIV-1 acquisition and transmission represents an important public health issue. Several observational studies have suggested an association between the use of hormonal contraception, in particular injectable depot medroxyprogesterone acetate (DMPA), and an increased risk of HIV-1 acquisition and transmission. To delineate the biological mechanisms behind this phenomenon, we have recruited healthy, HIV-negative women using either DMPA, NuvaRing, or combined oral contraceptives for a vaginal biopsy and cervicovaginal lavage (CVL). Analysis of the functional capacity of circulating plasmacytoid dendritic cells (pDCs), distribution of vaginal immune cell populations, and systemic and genital levels of immune …


Structural Implications Of P22 Bacteriophage Coat Protein A-Domain Modifications, David Samuel Morris Jan 2014

Structural Implications Of P22 Bacteriophage Coat Protein A-Domain Modifications, David Samuel Morris

All ETDs from UAB

Modification of virus capsids as target-specific delivery devices has become highly popularized in recent years and P22 bacteriophage has been proposed as a potential candidate for development of a targeting drug delivery system. As a proof of concept for our system, we hypothesized that the A-domain of P22 coat protein could be utilized to alter the binding affinity of virus-like procapsids for biological targets. Addition of acidic residues to the A-domain revealed that this could be accomplished through the quarternary localization of charged residues in three-dimensional space without interrogating procapsid assembly. Further manipulations implemented in vivo were performed to examine …


Characterization Of Glycosylation-Associated Protein, Gap2, Required For The Biogenesis Of Streptococcus Parasanguinis Fimbriae-Associated Protein, Fap1, Haley Echlin Jan 2014

Characterization Of Glycosylation-Associated Protein, Gap2, Required For The Biogenesis Of Streptococcus Parasanguinis Fimbriae-Associated Protein, Fap1, Haley Echlin

All ETDs from UAB

Streptococcal species possess a multitude of adhesins that facilitate adherence to a wide range of substrates; this is the first step necessary for the development of disease. Streptococcus parasanguinis is a primary colonizer of the oral cavity and adheres to the tooth surface using long fimbriae, which are composed of Fap1, a serine-rich repeat glycoprotein (SRRP). SRRPs are conserved in many Gram-positive bacteria and play a role in bacterial adhesion, fimbrial formation, biofilm formation, and bacterial pathogenesis. Although SRRPs play such an important role, the exact mechanism of their biogenesis remains a mystery. For Fap1, an eleven gene cluster is …


Innate Immune Defense Against The Fungal Pathogen Aspergillus Fumigatus, Melissa Ann Gessner Jan 2014

Innate Immune Defense Against The Fungal Pathogen Aspergillus Fumigatus, Melissa Ann Gessner

All ETDs from UAB

The opportunistic fungal pathogen Aspergillus fumigatus is a ubiquitous mold that causes severe, invasive life-threatening infections in patients that are severely immunocompromised. Major risk factors include neutropenia, neutrophil dysfunction and immunosuppressive therapies. Recently, however, rising incidences of colonizing A. fumigatus have been reported in patients without classical risk factors. We sought out to elucidate non-classical pre-disposing conditions that may render a lung environment susceptible to fungal colonization as well as mechanisms involved in immune defense against the invading fungal pathogen. Further defining a role for Dectin-1 in an Aspergillus fumigatus infection, we demonstrated a critical role for Dectin-1 dependent interleukin-22 …


Using Mce4 Sirna Molecular Beacons For Detection And Eradication Of Mycobacterial Infection In Macrophages, Remo George Jan 2014

Using Mce4 Sirna Molecular Beacons For Detection And Eradication Of Mycobacterial Infection In Macrophages, Remo George

All ETDs from UAB

temperatures. The third chapter represents the most comprehensive evaluation to date of


Assessing The Active Kinome Of Influenza Virus Infected A549 Cells, Colm Atkins Jan 2014

Assessing The Active Kinome Of Influenza Virus Infected A549 Cells, Colm Atkins

All ETDs from UAB

Influenza A Virus is a respiratory pathogen of the family Orthomyxoviridae and causes significant worldwide morbidity and mortality during seasonal epidemics and periodic pandemics. As with all viruses, influenza's limited coding capacity requires the use of host proteins and processes in its replication and release cycle. Phosphorylation, mediated by cellular kinases and phosphatases, represents a significant mechanism of post-translational modification of cellular products, and is responsible for regulating the activi-ty, lifespan and localization of many lipids and proteins in host-cells. Several cellular kinases have been associated with various steps of the Influenza lifecycle, including PKC-ßII (viral entry), PKR (host defense), …


Cutting Effectiveness Of Diamond Burs On Dental Zirconia., Ching-Kai Lin Jan 2014

Cutting Effectiveness Of Diamond Burs On Dental Zirconia., Ching-Kai Lin

All ETDs from UAB

Monolithic zirconia restorations are popular but removing these crowns is difficult. The purpose of the study is to measure and compare the cutting effectiveness of 10 types of diamond burs through monolithic sintered zirconia. Ten types of diamond burs (n=8) were compared for the cutting effectiveness in Zirconia (CERCON; DeguDent) using a high speed computer controlled cutting device with water spray (5.45L/min). The turbine used to cut the blocks rotated at 150,000 rpm and with the burs at a depth of 2mm into the zirconia during cutting. A 100 gm load was applied during cutting for each bur which made …