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University of Alabama at Birmingham

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Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth Jan 2017

Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth

All ETDs from UAB

A. fumigatus is one of the most common fungal isolates with clinical disorders ranging from mild to severe. The development of Aspergillus-induced allergic and invasive fungal infections is a major health concern in several patient populations. IL-1 family members have been shown to play critical roles in host defense against A. fumigatus. IL-33, an IL-1 family member widely study in allergic and inflammatory diseases, was induced upon acute exposure to A. fumigatus. IL-33 receptor knockout mice, (Il1rl1-/-), demonstrated lower lung fungal burden in the presence of enhanced IL-1α, IL-1β, IL-6, IL-17A, IL-22, and PGE2 production. Administration of IL-33 to normal …


Bioactive Materials: Ion Release, Flexural Strength, Secondary Caries Depth And Elemental Analysis Of Surrounding Tooth Structure, Prajakta Shreeram Kulkarni Jan 2017

Bioactive Materials: Ion Release, Flexural Strength, Secondary Caries Depth And Elemental Analysis Of Surrounding Tooth Structure, Prajakta Shreeram Kulkarni

All ETDs from UAB

ABSTRACT Objectives: Bioactive materials release calcium, phosphate, and fluoride which may increase tooth remineralization. But limited data is available demonstrating the superiority of bioactive or ion releasing materials compared to fluoride or no ion releasing materials. The aims of the present study are to measure and compare the calcium, fluoride, and phosphate ion release at different pH, flexural strength and caries protecting ability of the materials including the ion uptake of surrounding tooth structure. Methods: Activa, Cention N, Fuji LC II and Filtek Supreme Ultra were the restorative materials tested. Firstly, the fluoride and calcium release of these materials was …


Uncovering The Role Of Common Gamma-Chain Cytokines In Aspergillus Fumigatus Associated Diseases, Kristen Marie Reeder Jan 2017

Uncovering The Role Of Common Gamma-Chain Cytokines In Aspergillus Fumigatus Associated Diseases, Kristen Marie Reeder

All ETDs from UAB

Fungal pathogens contribute to a wide range of diseases that are largely dependent on the host’s immune state. In the case of immune suppression, Aspergillus fumigatus is the causative agent of invasive aspergillosis. Furthermore, asthmatics sensitized to fungi such as Aspergillus fumigatus are reported to have more severe asthma. We have previously described a role for IL-22 in mouse models of invasive aspergillosis and fungal asthma. IL-22 was found to play a protective role in invasive aspergillosis, while it was found to play an immunopathogenic role in asthma. Here we describe the cell sources of IL-22 in both models. We …


Evaluation Of Peripheral And Mucosal T Cell Phenotypes Of Chlamydia-Infected Women, Brian Makori Omwena Ogendi Jan 2017

Evaluation Of Peripheral And Mucosal T Cell Phenotypes Of Chlamydia-Infected Women, Brian Makori Omwena Ogendi

All ETDs from UAB

Chlamydia trachomatis (CT) infection is the most prevalent bacterial sexually transmitted infection worldwide and women are disproportionately affected due to its reproductive complications. T cell phenotypes present during CT infection have been well characterized in the murine model, but remain to be elucidated in humans. Therefore, studies aimed at increasing our understanding of T cell phenotypes in CT-infected humans were the focus of this dissertation. The first chapter of this dissertation reviews various aspects of chlamydial infection while in the second chapter aims to address the influence of CT infection on T cell phenotypes. We first compared differences in peripheral …


Uab Emergency Docs Take Teaching Skills To Kenya, Staff Dec 2016

Uab Emergency Docs Take Teaching Skills To Kenya, Staff

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No abstract provided.


Uab Celebrates World Aids Day 2016 And 30 Years Of Research In The Clinical Trials Network, Alicia Rohan Nov 2016

Uab Celebrates World Aids Day 2016 And 30 Years Of Research In The Clinical Trials Network, Alicia Rohan

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No abstract provided.


International Hiv Symposium Comes To Birmingham, Staff Nov 2016

International Hiv Symposium Comes To Birmingham, Staff

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No abstract provided.


Uab Professor Honored With Prestigious Award And Grant By Ronald Mcdonald House Charities, Staff Nov 2016

Uab Professor Honored With Prestigious Award And Grant By Ronald Mcdonald House Charities, Staff

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No abstract provided.


Health Services Foundation Awards $1.5 Million In General Endowment Fund Grants, Kendra Carter Nov 2016

Health Services Foundation Awards $1.5 Million In General Endowment Fund Grants, Kendra Carter

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No abstract provided.


Saving Lives By Making Pneumonia Vaccine Affordable, Jeff Hansen Oct 2016

Saving Lives By Making Pneumonia Vaccine Affordable, Jeff Hansen

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No abstract provided.


Saving Lives By Making Pneumonia Vaccine Affordable, Jeff Hansen Oct 2016

Saving Lives By Making Pneumonia Vaccine Affordable, Jeff Hansen

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No abstract provided.


Chapman Is A National Voice For Reforming 'Wasteland Of The Mind', Deb Lucas Sep 2016

Chapman Is A National Voice For Reforming 'Wasteland Of The Mind', Deb Lucas

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No abstract provided.


Serving Underrepresented Graduate Students: Uab's Neural Conference, Jeff Hansen Sep 2016

Serving Underrepresented Graduate Students: Uab's Neural Conference, Jeff Hansen

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No abstract provided.


Serving Underrepresented Graduate Students: Uab's Neural Conference, Jeff Hansen Sep 2016

Serving Underrepresented Graduate Students: Uab's Neural Conference, Jeff Hansen

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No abstract provided.


Medical Considerations For International Travel, Alicia Rohan Aug 2016

Medical Considerations For International Travel, Alicia Rohan

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No abstract provided.


Willig Named New Assistant Dean For Clinical Education, Kendra Carter Aug 2016

Willig Named New Assistant Dean For Clinical Education, Kendra Carter

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No abstract provided.


Uab Researchers Awarded $11.5 Million To Study Asymptomatic Congenital Cmv And Neonatal Hsv, Staff Jul 2016

Uab Researchers Awarded $11.5 Million To Study Asymptomatic Congenital Cmv And Neonatal Hsv, Staff

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No abstract provided.


Likelihood Of Widespread Zika Outbreak In United States Low, Alicia Rohan Jun 2016

Likelihood Of Widespread Zika Outbreak In United States Low, Alicia Rohan

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No abstract provided.


In U.S. First, Uab Physician Uses Telehealth To Replace Comprehensive Face-To-Face Visit For Home Dialysis Patient, Tyler Greer Jun 2016

In U.S. First, Uab Physician Uses Telehealth To Replace Comprehensive Face-To-Face Visit For Home Dialysis Patient, Tyler Greer

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No abstract provided.


Nih Launches $9 Million Program To Train Workers On Infectious Disease Safety, Staff Jun 2016

Nih Launches $9 Million Program To Train Workers On Infectious Disease Safety, Staff

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No abstract provided.


Uab Developing Training Program On Ebola For First Responders In Deep South, Staff Jun 2016

Uab Developing Training Program On Ebola For First Responders In Deep South, Staff

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No abstract provided.


Uab Developing Training Program On Ebola For First Responders In Deep South, Staff Jun 2016

Uab Developing Training Program On Ebola For First Responders In Deep South, Staff

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No abstract provided.


Zika, Pregnancy And Microcephaly: What You Need To Know, Alicia Rohan Jun 2016

Zika, Pregnancy And Microcephaly: What You Need To Know, Alicia Rohan

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No abstract provided.


Uab Developing Training Program On Ebola For First Responders In Deep South, Alicia Rohan Jun 2016

Uab Developing Training Program On Ebola For First Responders In Deep South, Alicia Rohan

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No abstract provided.


Teaching Metabolomics: A Uab Outreach To Researchers In Sub-Saharan Africa, Jeff Hansen May 2016

Teaching Metabolomics: A Uab Outreach To Researchers In Sub-Saharan Africa, Jeff Hansen

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No abstract provided.


Eleven Faculty Members Named Winners Of The 2016 Dean's Excellence Awards, Kendra Carter May 2016

Eleven Faculty Members Named Winners Of The 2016 Dean's Excellence Awards, Kendra Carter

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No abstract provided.


New Chemical From Antarctic Sponge Extract Kills Mrsa Biofilm, Staff May 2016

New Chemical From Antarctic Sponge Extract Kills Mrsa Biofilm, Staff

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No abstract provided.


Hiv Vaccine Design Should Adapt As Hiv Virus Mutates, Alicia Rohan May 2016

Hiv Vaccine Design Should Adapt As Hiv Virus Mutates, Alicia Rohan

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No abstract provided.


Uab Hospital Recognized For Decreasing Inappropriate Use Of Antibiotics, Alicia Rohan May 2016

Uab Hospital Recognized For Decreasing Inappropriate Use Of Antibiotics, Alicia Rohan

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No abstract provided.


Four From Uab Named To Association Of American Physicians, Staff Apr 2016

Four From Uab Named To Association Of American Physicians, Staff

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No abstract provided.