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Uab Observational Study Of Zika Virus Infection During Pregnancy Begins In Brazil, Alicia Rohan Apr 2016

Uab Observational Study Of Zika Virus Infection During Pregnancy Begins In Brazil, Alicia Rohan

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No abstract provided.


Alabama Vaccine Research Clinic Recruiting For New Clinical Trial For Preventive Antibody For Hiv, Alicia Rohan Apr 2016

Alabama Vaccine Research Clinic Recruiting For New Clinical Trial For Preventive Antibody For Hiv, Alicia Rohan

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No abstract provided.


Understanding And Improving Treatment Adherence: A Research Opportunity And Patient Need, Jeff Hansen Mar 2016

Understanding And Improving Treatment Adherence: A Research Opportunity And Patient Need, Jeff Hansen

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No abstract provided.


Study At Uab Personal Health Clinic Recruiting For New Clinical Trial Looking At Prevention Of Recurrent Bacterial Vaginosis, Alicia Rohan Mar 2016

Study At Uab Personal Health Clinic Recruiting For New Clinical Trial Looking At Prevention Of Recurrent Bacterial Vaginosis, Alicia Rohan

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No abstract provided.


Understanding And Improving Treatment Adherence: A Research Opportunity And Patient Need, Jeff Hansen Mar 2016

Understanding And Improving Treatment Adherence: A Research Opportunity And Patient Need, Jeff Hansen

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No abstract provided.


New Reference For Physicians Treating Hiv Patients With Chronic Pain, Alicia Rohan Mar 2016

New Reference For Physicians Treating Hiv Patients With Chronic Pain, Alicia Rohan

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No abstract provided.


Top Hiv/Aids Researcher Recruited To Uab For Leadership Post, Staff Mar 2016

Top Hiv/Aids Researcher Recruited To Uab For Leadership Post, Staff

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No abstract provided.


Vaccine Expert Offit To Give 2016 Kennamer Distinguished Lecture In Montgomery, Uab Heersink School Of Medicine News Mar 2016

Vaccine Expert Offit To Give 2016 Kennamer Distinguished Lecture In Montgomery, Uab Heersink School Of Medicine News

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No abstract provided.


Uab Division Of Infectious Diseases Taps New Leadership, Staff Mar 2016

Uab Division Of Infectious Diseases Taps New Leadership, Staff

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No abstract provided.


Three Honored For 45 Years Service During Annual Awards, Traci Bratton Feb 2016

Three Honored For 45 Years Service During Annual Awards, Traci Bratton

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No abstract provided.


Salmonella Expert Presents At 28th Bertram Marx Lecture At Uab, Staff Feb 2016

Salmonella Expert Presents At 28th Bertram Marx Lecture At Uab, Staff

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No abstract provided.


World-Renowned Geneticist To Speak At 2016 Bertram M. Marx Lectureship, Ella Robinson Feb 2016

World-Renowned Geneticist To Speak At 2016 Bertram M. Marx Lectureship, Ella Robinson

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No abstract provided.


Researchers Studying The Effects Of New Hiv-Prevention Method In Postpartum, Lactating Women, Alicia Rohan Feb 2016

Researchers Studying The Effects Of New Hiv-Prevention Method In Postpartum, Lactating Women, Alicia Rohan

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No abstract provided.


Protect Yourself Against Infectious Disease, Here And Abroad, Traci Bratton Feb 2016

Protect Yourself Against Infectious Disease, Here And Abroad, Traci Bratton

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No abstract provided.


Zika Answers, Staff Feb 2016

Zika Answers, Staff

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No abstract provided.


Two Department Of Medicine Professors Elected To Asci, Carolyn Walsh Jan 2016

Two Department Of Medicine Professors Elected To Asci, Carolyn Walsh

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No abstract provided.


Test Question: Can Games Help Train Future Doctors And Nurses?, Staff Jan 2016

Test Question: Can Games Help Train Future Doctors And Nurses?, Staff

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No abstract provided.


Azithromycin Safe, Effective Treatment For Chlamydia, Staff Jan 2016

Azithromycin Safe, Effective Treatment For Chlamydia, Staff

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No abstract provided.


Uab Magazine - Fall 2016, University Of Alabama At Birmingham Jan 2016

Uab Magazine - Fall 2016, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.


Germline Restriction Of B Cell Receptor Repertoire Influences Antigenic Epitope Recognition And Primary Antibody Deficiency Pathogenesis, Yuge Wang Jan 2016

Germline Restriction Of B Cell Receptor Repertoire Influences Antigenic Epitope Recognition And Primary Antibody Deficiency Pathogenesis, Yuge Wang

All ETDs from UAB

Part I. Mouse Studies Complementarity determining region 3 of the immunoglobulin (Ig) H chain (CDR-H3) lies at the center of the antigen binding site where it often plays a decisive role in antigen recognition and binding. Amino acids encoded by the diversity (DH) gene segment are the main component of CDR-H3. Each DH has the potential to rearrange into one of six DH reading frames (RFs), each of which exhibits a characteristic amino acid hydrophobicity signature that has been conserved among jawed vertebrates by natural selection. A preference for use of RF1 promotes the incorporation of tyrosine into CDR-H3 while …


Regulation Of Vibrio Cholerae Biofilm Formation By H-Ns Repression And Anti-Repression, Julio Cesar Ayala-Figueredo Jan 2016

Regulation Of Vibrio Cholerae Biofilm Formation By H-Ns Repression And Anti-Repression, Julio Cesar Ayala-Figueredo

All ETDs from UAB

The diarrheal disease cholera is caused by the Gram-negative and motile bacterium Vibrio cholerae of serogroups O1 and O139. V. cholerae can switch between planktonic (motile) and sessile (biofilm) lifestyles. Biofilms are sessile communities encased in a self-produced extracellular matrix mainly composed of exopolysaccharide, proteins and extracellular DNA. Biofilm formation enhances the capacity of V. cholerae to persist in environmental waters and increases its infectivity. The bacterial second messenger cyclic diguanylic acid (c-di-GMP) regulates the transition between motile and biofilm lifestyles in V. cholerae. At low cell density, two c-di-GMP receptors, the LuxR-type regulator VpsT and the NtrC-type regulator VpsR …


Fcrl5 Counter-Regulates Natural And T Cell-Independent Immunoglobulin Production By Innate-Like B Cells, Eugene John Becker Jan 2016

Fcrl5 Counter-Regulates Natural And T Cell-Independent Immunoglobulin Production By Innate-Like B Cells, Eugene John Becker

All ETDs from UAB

At homeostasis and during the initial phases of primary responses to pathogens, humoral host defense is chiefly coordinated by specialized B cells known as splenic marginal zone (MZ) and body cavity-derived B-1 B cells. These front line immune mediators are termed “innate like” due to their ability to secrete broadly-reactive natural antibodies and respond rapidly to antigens in a T cell-independent manner. The production of natural antibodies possessing specificities for self-antigens allows clearance of cellular debris, maintenance of homeostasis and protection from infections that can also predispose the host to immunological disease. However, how the functions of these specialized cells …


Targeting The Tumor-Promoting Microenvironment With Inhibitors Of Pro-Hgf Activation, Benjamin Yaw Owusu Jan 2016

Targeting The Tumor-Promoting Microenvironment With Inhibitors Of Pro-Hgf Activation, Benjamin Yaw Owusu

All ETDs from UAB

The tumor microenvironment plays a key role in tumor progression and therapeutic resistance. Hepatocyte growth factor (HGF), commonly expressed by cancer-associated fibroblasts, mediates signaling via its receptor, MET, and promotes survival, proliferation, migration and invasion of cancer cells. In addition, HGF dependence has emerged as a hallmark of therapeutic resistance. HGF is secreted as an inactive precursor, pro-HGF, which requires proteolytic cleavage and processing to form the mature, active HGF. This is the rate-limiting step in the HGF/MET signaling pathway and it is achieved by one of the serine proteases, matriptase, hepsin and HGF activator (HGFA). At Southern Research, we …


Glycosyltransferases Involved In The Glycosylation Of Serine-Rich Glycoproteins From Streptococci, Fan Zhu Jan 2016

Glycosyltransferases Involved In The Glycosylation Of Serine-Rich Glycoproteins From Streptococci, Fan Zhu

All ETDs from UAB

Serine - rich repeat glycoproteins (SRRPs) play important roles in mediating bac-terial attachment to a variety of host and microbial surfaces. They have been im-plicated in the development of tissue infections such as pneumonia, infective en-docarditis, meningitis and oral infectious diseases. Streptococcus parasanguinis, one of the commensal streptococci present in the oral cavity, utilizes its fimbriae to mediate the initial attachment to the tooth pellicle. Fap1 (Fimbriae-associated-protein 1), the first identified SRRP, is the subunit of the fimbriae which utilizes proteins encoded by an 11-gene cluster (gly-gtf3-dGT1-galT2 and secY2-gap1-gap2-gap3-secA2-gtf1-gtf2) to mediate its glycosylation and secretion. The key enzymes responsible for …


Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia Jan 2016

Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia

All ETDs from UAB

program pilot study randomly assigned 100 women, aged 19 to 25 to two groups. One


The Roles Of Il-21 And Il-10 In Cellular And Humoral Immune Responses, Yuan Tian Jan 2016

The Roles Of Il-21 And Il-10 In Cellular And Humoral Immune Responses, Yuan Tian

All ETDs from UAB

values, it may be more appropriate to use CH


Molecular Analysis Of Streptococcus Mutans Genetic Diversity For The Epidemiological Study Of Oral Disease, Stephanie Stahlbuhk Momeni Jan 2016

Molecular Analysis Of Streptococcus Mutans Genetic Diversity For The Epidemiological Study Of Oral Disease, Stephanie Stahlbuhk Momeni

All ETDs from UAB

Dental caries is chronic global infectious disease. Streptococcus mutans are most frequently associated with dental caries. The goal of this work is to use molecular genotyping methods to investigate the genetic diversity and evidence for transmission of S. mutans for the epidemiological study of dental caries. It was first necessary to validate methods proposed in this study including choice of selective media, choice of multilocus sequence typing (MLST) scheme, and the frequency of clonality. Analysis included 13,906 S. mutans isolates obtained from oral samples collected from children and their household members in an 8-year longitudinal epidemiological study. Two genotyping methods …


Dietary Patterns, Insulin Resistance, And Cognitive Outcomes In A Cohort Of Black And White Americans, Keith Pearson Jan 2016

Dietary Patterns, Insulin Resistance, And Cognitive Outcomes In A Cohort Of Black And White Americans, Keith Pearson

All ETDs from UAB

As life expectancy continues to increase and the number of elderly Americans rises, public health initiatives are seeking to identify modifiable risk factors to preserve cognitive function and increase quality of life in advanced ages. The primary objective of this dissertation was to investigate dietary patterns, carbohydrate consumption, and insulin resistance as modifiable risk factors that may contribute to the development of cognitive impairment and cognitive decline. Three separate studies were performed in the REasons for Geographic And Racial Differences in Stroke study, a prospective cohort containing 30,239 black and white participants. Cognitive impairment was defined using the Six-Item Screener. …


Uab Study Confirms Efficacy Of Major Chlamydia Drug, Alicia Rohan Dec 2015

Uab Study Confirms Efficacy Of Major Chlamydia Drug, Alicia Rohan

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No abstract provided.


Deadly Candidiasis Must Be Addressed Swiftly To Help Vulnerable Patients, Staff Dec 2015

Deadly Candidiasis Must Be Addressed Swiftly To Help Vulnerable Patients, Staff

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No abstract provided.