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Assessing Diabetes Risk Among Hispanic Populations: Development And Validation Of A Risk Score Using Readily Available Information, Lucia Juarez Jan 2019

Assessing Diabetes Risk Among Hispanic Populations: Development And Validation Of A Risk Score Using Readily Available Information, Lucia Juarez

All ETDs from UAB

Background: Diabetes prevalence is increasing worldwide affecting vulnerable popula-tions, in particular Hispanics living in the United States (U.S.). The burden of diabetes and its complications can be reduced by identifying those at high risk and routing them to treatment and intensive behavioral interventions. Aim: The aim of this study is to develop and validate a simple score to identify undiag-nosed diabetes among Hispanics living in the U.S. Methods: A representative sample of Hispanics living in the U.S. was used to develop and validate the score. Logistic regression was used to identify significant risk factors and model coefficients were used to …

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St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty Jan 2019

St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty

All ETDs from UAB

ST6Gal-I adds α2-6 sialic acids to select N-glycosylated cell surface receptors, thereby modulating receptor function and intracellular signaling. ST6Gal-I is upregulated in various carcinomas and confers cancer stem cell (CSC) properties evidenced by tumorspheroid growth, chemoresistance and tumor initiating potential. In pancreatic ductal adenocarcinoma (PDAC), ST6Gal-I conferred gemcitabine resistance by abrogating DNA damage and altering expression levels of gemcitabine metabolism genes. Further, ST6Gal-I promoted resistance to chronic gemcitabine treatment. Additionally, metastatic clones of a PDAC cell line had increased ST6Gal-I expression and ST6Gal-I knockdown enhanced gemcitabine sensitivity. To investigate the physiological consequences of ST6Gal-I in PDAC, murine models were used. …

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Modeling Resilience In Resetttled Syrian Refugees With Disabilities Living In The United States, Nicholas Ryan Sherwood Jan 2019

Modeling Resilience In Resetttled Syrian Refugees With Disabilities Living In The United States, Nicholas Ryan Sherwood

All ETDs from UAB

Since 2011, the ongoing conflict in Syria displaces millions of individuals, many of whom have resettled across foreign borders. The US currently hosts 21,000 Syrian refugees, and of these, approximately 5,000 have at least one type of disability. This thesis asks of these individuals: given your experience as a person with a disability who has survived state-sanctioned violence and navigated forced migration, what have been your greatest sources of strength and resilience? Utilizing systems theory and a transdisciplinary approach, this thesis examines how three forms of identity promote community, interpersonal, and intrapersonal resilience within the target population.

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Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson Jan 2019

Unintentional Childhood Injuries In Rural Uganda: The Role Of Sibling Supervision And The Potential For Behavior Change Through Classroom-Based Instruction, Marissa Swanson

All ETDs from UAB

Objective: Unintentional childhood injury is a significant global health burden particularly in low and middle income countries (LMIC). Effective supervision can reduce risk of injury to supervisees. Frequently, older siblings assist in supervising younger siblings, but may not be as effective as adult caregivers at preventing supervisee injury. The current investigation had three primary objectives: 1) Assess Ugandan adult caregivers’ self-reported expectations for children to provide sibling supervision; 2) Assess sixth-grade students’ self-reported experiences providing supervision; 3) Determine whether students’ supervision knowledge and skill improve through participation in the Super Siblings program, a novel classroom-based, culturally-adapted intervention. Methods: Adult caregivers …

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Transition Into Adulthood: Cannabis Use And Mental Health, Katie Mcintyre Jan 2019

Transition Into Adulthood: Cannabis Use And Mental Health, Katie Mcintyre

All ETDs from UAB

The US is currently experiencing sweeping changes in the legal status of cannabis, the most common illicit drug used in America. Due to its classification as a Schedule I substance we know very little about how cannabis use impacts mental health since illicit drugs are not legally allowed to be researched in a laboratory setting. The current research on cannabis use (CU) and mental health (MH) is expansive and conflicting. One side of the debate suggests CU in adolescence has a direct effect on MH, the other side suggests CU could be an indirect coping mechanism of poor MH. One …

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A Crown Of Autopsies, D Gilson Jan 2019

A Crown Of Autopsies, D Gilson

Birmingham Poetry Review

pp. 121-126

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Classic Findings May Not Be Typical: A Rare Case Of Cutaneous Larva Migrans, Andrei Lojek, Erin Britt, Ali Hassoun Jan 2019

Classic Findings May Not Be Typical: A Rare Case Of Cutaneous Larva Migrans, Andrei Lojek, Erin Britt, Ali Hassoun

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Non-Operative Management Of Leaking Thoracic Aortic Aneurysms, Charles Reeder, Jeremy Johnson, Shivani Malhotra Jan 2019

Non-Operative Management Of Leaking Thoracic Aortic Aneurysms, Charles Reeder, Jeremy Johnson, Shivani Malhotra

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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An Unusual Consequence Of Alcoholism And Recurrent Pancreatitis, Mrudula Thiriveedi, Suresh Karne, Parekha Yedla Jan 2019

An Unusual Consequence Of Alcoholism And Recurrent Pancreatitis, Mrudula Thiriveedi, Suresh Karne, Parekha Yedla

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Headache: Not Just A Migraine Or Tension Headache, Sujatha Baddam, Sanjay Muttineni, Anjaneyulu Alapati Jan 2019

Headache: Not Just A Migraine Or Tension Headache, Sujatha Baddam, Sanjay Muttineni, Anjaneyulu Alapati

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Watch Your Children Grow: Learning How To Address Obesity In Underserved Populations, Meredith Lewis, Denise Surina-Baumgartner, Shivani Malhotra, Rajalakshmi Cheerla Jan 2019

Watch Your Children Grow: Learning How To Address Obesity In Underserved Populations, Meredith Lewis, Denise Surina-Baumgartner, Shivani Malhotra, Rajalakshmi Cheerla

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Recurrent Falls In A Patient With Suspected Ovarian Cancer: A Rare Case Of Lower Extremity Weakness, Noaman Ahmad, Aadil Lodhi, Ali Hassoun Jan 2019

Recurrent Falls In A Patient With Suspected Ovarian Cancer: A Rare Case Of Lower Extremity Weakness, Noaman Ahmad, Aadil Lodhi, Ali Hassoun

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Septic Knee Monoarthritisdue To Histoplasma Capsulatum After Bone Marrow Transplant In A Patient With Aplastic Anemia, Bhavyaa Bahl, Lourdes Corman Jan 2019

Septic Knee Monoarthritisdue To Histoplasma Capsulatum After Bone Marrow Transplant In A Patient With Aplastic Anemia, Bhavyaa Bahl, Lourdes Corman

UAB Huntsville Research Day - All Presentations

2019 clinical vignette poster

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Streptococcal Bacteremia In A Large Tertiary Center, Aristotle Asis, Ali Hassoun, Esmerelda Guiterrez-Asis Jan 2019

Streptococcal Bacteremia In A Large Tertiary Center, Aristotle Asis, Ali Hassoun, Esmerelda Guiterrez-Asis

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Mycotic Aneurysm, Jose Cavo, Jesse Faulk, Aristotle Asis, Farrah Ibrahim Jan 2019

Mycotic Aneurysm, Jose Cavo, Jesse Faulk, Aristotle Asis, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Better Transitional Care & Reimbursement Outcomes With Introduction Of Toc Template In Her, Kelly Diaz, Shivani Malhotra Jan 2019

Better Transitional Care & Reimbursement Outcomes With Introduction Of Toc Template In Her, Kelly Diaz, Shivani Malhotra

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Influenza 2017-2018, Rohini Ramamoorthy, Soujanya Thummathati, Bhavyaa Bahl, Ali Hassoun Jan 2019

Influenza 2017-2018, Rohini Ramamoorthy, Soujanya Thummathati, Bhavyaa Bahl, Ali Hassoun

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Rapidly Progressive Acute Respiratory Failure As Initial Presentation Of Idiopathic Pulmonary Fibrosis (Ipf), Swetha Srialluri, Mohammed Abdulhaleem, Syeda Sabeeka Batool, Farrah Ibrahim Jan 2019

Rapidly Progressive Acute Respiratory Failure As Initial Presentation Of Idiopathic Pulmonary Fibrosis (Ipf), Swetha Srialluri, Mohammed Abdulhaleem, Syeda Sabeeka Batool, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Factors Influencing Specialty Choice And Rural Family Medicine, Phillip Ingram, David Bramm, Paula Clawson, Kyle Siegrist Jan 2019

Factors Influencing Specialty Choice And Rural Family Medicine, Phillip Ingram, David Bramm, Paula Clawson, Kyle Siegrist

UAB Huntsville Research Day - All Presentations

2019 research poster

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A Curious Case Of Eosinophilia, Elizabeth Thottacherry, Ali Hassoun Jan 2019

A Curious Case Of Eosinophilia, Elizabeth Thottacherry, Ali Hassoun

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Epidemiology Of Extended-Spectrum Beta Lactamase Producing Organism Infections In A Large Tertiary Center, Aristotle Asis, Ali Hassoun, Esmerelda Guiterrez-Asis, Elizabeth Rosell-Cespedes, Claire Bourgeois Jan 2019

Epidemiology Of Extended-Spectrum Beta Lactamase Producing Organism Infections In A Large Tertiary Center, Aristotle Asis, Ali Hassoun, Esmerelda Guiterrez-Asis, Elizabeth Rosell-Cespedes, Claire Bourgeois

UAB Huntsville Research Day - All Presentations

2019 research poster

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Curriculum Development: Controlled Substance Prescribing And Diversion Prevention In A Family Medicine Residency Program, J Johnson, H Phillippe Jan 2019

Curriculum Development: Controlled Substance Prescribing And Diversion Prevention In A Family Medicine Residency Program, J Johnson, H Phillippe

UAB Huntsville Research Day - All Presentations

2019 research poster

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Using Vision Screenings To Educate Communities About Health, Meredith Lewis, Shivani Malhotra, Amanda Stisher, Bal Krishna Mainali Jan 2019

Using Vision Screenings To Educate Communities About Health, Meredith Lewis, Shivani Malhotra, Amanda Stisher, Bal Krishna Mainali

UAB Huntsville Research Day - All Presentations

2019 research poster

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Interprofessionaldebate Activity As A Method Of Literature Evaluation: A Two-Year Analysis, Tayler Steuber, Haley Phillippe, Brad Wright, Miranda Andrus Jan 2019

Interprofessionaldebate Activity As A Method Of Literature Evaluation: A Two-Year Analysis, Tayler Steuber, Haley Phillippe, Brad Wright, Miranda Andrus

UAB Huntsville Research Day - All Presentations

2019 research poster

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Geographic Proximity To Healthy Food Not Associated With Increased Prevalence Of Cardiovascular Risk Factors In Stroke Patients, Alan D. Howard, Chigozirim Izeogu, Adeniyi J. Idigo, Michael J. Lyerly Jan 2019

Geographic Proximity To Healthy Food Not Associated With Increased Prevalence Of Cardiovascular Risk Factors In Stroke Patients, Alan D. Howard, Chigozirim Izeogu, Adeniyi J. Idigo, Michael J. Lyerly

UAB Huntsville Research Day - All Presentations

2019 research poster

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A Tumor That Would Not Be Flushed, Luke Bailey, Parekha Yedla Jan 2019

A Tumor That Would Not Be Flushed, Luke Bailey, Parekha Yedla

UAB Huntsville Research Day - All Presentations

2019 oral presentation

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Biopsychosocial Correlates Of Pain In Youth With Eosinophilic Esophagitis: A Comparison To Other Pediatric Patients, Mary Kenna Lynch Jan 2019

Biopsychosocial Correlates Of Pain In Youth With Eosinophilic Esophagitis: A Comparison To Other Pediatric Patients, Mary Kenna Lynch

All ETDs from UAB

EoE is a chronic, clinico-pathological, esophageal disease with symptoms that include dysphagia, reflux, vomiting, feeding aversion, and epigastric pain. Diagnosis requires clinical symptom presentation and histologic findings of eosinophil-predominant inflammation of the esophagus. While the pediatric patient’s epigastric pain is predictive of their quality of life, little is known about their pain experience. Through two studies, the pain experience, sleep quality, and internalizing symptoms of youth with Eosinophilic Esophagitis (EoE) have been examined. Through individually evaluating each of these factors as well as testing their relations with each other, the model proposed by Lynch and colleagues (2015) to understand the …

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Healthcare Cybersecurity: Building A Cyber Vulnerability Profile For U.S. Hospitals, Gemini O. Majkowski Jan 2019

Healthcare Cybersecurity: Building A Cyber Vulnerability Profile For U.S. Hospitals, Gemini O. Majkowski

All ETDs from UAB

Digital transformation in healthcare has offered exponential advances in capabilities and efficiencies improving access, quality of care, chronic disease management, public health surveillance, and population health. However, the speed of change left security lagging, exposing cyber vulnerabilities that cost the U.S. $6.2 billion dollars annually, at an average cost of $2.2 million dollars, and 3,128 records breached per incident. Despite significant investments to close the gap on cyber vulnerabilities, cybersecurity remains a critical issue. Little research has been done to build a cyber vulnerability profile for U.S. hospitals. In this study, U.S. hospitals with reportable breach and without reportable breach …

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An Investigation Of Histocompatibility Testing And Mhc Class I In Xenotransplantation, Gregory Ryan Martens Jan 2019

An Investigation Of Histocompatibility Testing And Mhc Class I In Xenotransplantation, Gregory Ryan Martens

All ETDs from UAB

In the United States, hundreds of thousands of patients suffer from end-stage organ failure or terminal diseases without the option of a life-saving transplant because of severe organ shortages. Xenotransplantation offers a possible solution by using genetically engineered pigs as organ donors. Application of pig-to-human organ transplantation has been limited by antibody-mediated rejection (AMR), but recent genetic engineering advances have eliminated pig glycan xenoantigens and dramatically reduced antibody binding. In human-to-human transplantation, allotransplantation, AMR is prevented by pretransplant screening donors and recipients. The major histocompatibility complex (MHC), class I and II, are primary targets for antibodies and may also bind …

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Appropriately Timed Epigenetic Manipulation With Histone Deacetylase Inhibitors As A Platform Approach To Tumor Immunotherapy, Tyler Mccaw Jan 2019

Appropriately Timed Epigenetic Manipulation With Histone Deacetylase Inhibitors As A Platform Approach To Tumor Immunotherapy, Tyler Mccaw

All ETDs from UAB

In contrast to chemotherapy and radiotherapy, immunotherapy is able to respond in proportion to tumor burden and continue to evolve in parallel with the tumor mass and metastatic sites. In this way, immune-based cancer therapies are a living drug and hold enormous potential. In this work, we enforce expression of MHCII on a murine breast cancer model to study how changes in tumor biology can drive improved T cell-mediated responses. We next use histone deacetylase inhibitors to manipulate the microenvironment through a more clinically relevant, therapeutic approach. Herein, improvements in tumor control were driven by CD8 T cells and IFNγ, …

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