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Three Uab Campus Buildings Received Abc Alabama Chapter Awards, Staff Jan 2019

Three Uab Campus Buildings Received Abc Alabama Chapter Awards, Staff

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No abstract provided.


Three Uab Campus Buildings Received Abc Alabama Chapter Awards, Alicia Rohan Jan 2019

Three Uab Campus Buildings Received Abc Alabama Chapter Awards, Alicia Rohan

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No abstract provided.


Obesity Surgery Leads To Emergence Of New Microbial Strains In The Human Fecal Community, Jeff Hansen Jan 2019

Obesity Surgery Leads To Emergence Of New Microbial Strains In The Human Fecal Community, Jeff Hansen

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No abstract provided.


Nurse Practitioner Residency To Improve Access To Mental Health Care For Children, Staff Jan 2019

Nurse Practitioner Residency To Improve Access To Mental Health Care For Children, Staff

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No abstract provided.


O'Neal Comprehensive Cancer Center At Uab Presents Artblink Gala 2019, Staff Jan 2019

O'Neal Comprehensive Cancer Center At Uab Presents Artblink Gala 2019, Staff

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No abstract provided.


Uab Earns Women's Choice Award "Best Hospital" Designation For Five Areas, Staff Jan 2019

Uab Earns Women's Choice Award "Best Hospital" Designation For Five Areas, Staff

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No abstract provided.


Does Your Insurance Card Matter When You Have A Heart Attack?, Adam Pope Jan 2019

Does Your Insurance Card Matter When You Have A Heart Attack?, Adam Pope

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No abstract provided.


Jack Honored For Contributions To Caribbean American Culture In Birmingham, Haley Herfurth Jan 2019

Jack Honored For Contributions To Caribbean American Culture In Birmingham, Haley Herfurth

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No abstract provided.


Impact Of Age On Romantic Relationships, Desire For Romance To Be Focus Of Jan. 4 Lecture, Staff Jan 2019

Impact Of Age On Romantic Relationships, Desire For Romance To Be Focus Of Jan. 4 Lecture, Staff

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No abstract provided.


Diary Of Our Fatal Illness, Susannah B. Mintz Jan 2019

Diary Of Our Fatal Illness, Susannah B. Mintz

Birmingham Poetry Review

pp. 257-265


Uab Magazine - Summer 2019, University Of Alabama At Birmingham Jan 2019

Uab Magazine - Summer 2019, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.


The Forgotten Liberal Years: George Wallace's Time As An Alabama State Representative, William Winner Jan 2019

The Forgotten Liberal Years: George Wallace's Time As An Alabama State Representative, William Winner

Vulcan Historical Review

pp. 13-21


Uab Magazine - Fall 2019/Winter 2020, University Of Alabama At Birmingham Jan 2019

Uab Magazine - Fall 2019/Winter 2020, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.


Vulcan Historical Review 23 (Complete Issue), Vulcan Historical Review Staff Jan 2019

Vulcan Historical Review 23 (Complete Issue), Vulcan Historical Review Staff

Vulcan Historical Review

No abstract provided.


Section 4: Sustainability & Design, Ectc Coordinating Committee Jan 2019

Section 4: Sustainability & Design, Ectc Coordinating Committee

Early Career Technical Journal (ECTJ)

Proceedings of the 19th Annual Early Career Technical Conference, November 2-3, 2019. School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama; pp. 76-95


Exploring Methodology For Development Of Sustainable Construction Management Processes In Puerto Rico, Magdelena Krstanoski, Rafael Melendez Jan 2019

Exploring Methodology For Development Of Sustainable Construction Management Processes In Puerto Rico, Magdelena Krstanoski, Rafael Melendez

Early Career Technical Journal (ECTJ)

Section 4: Sustainability & Design; pp. 78-83


Laws Of The Land: An Expedited Survey Of African American History And Legal Implications Of Slavery Through 1865, Kendra Bell Jan 2019

Laws Of The Land: An Expedited Survey Of African American History And Legal Implications Of Slavery Through 1865, Kendra Bell

Vulcan Historical Review

pp. 62-74


Avondale: A Neighborhood In Transition, Laura King Jan 2019

Avondale: A Neighborhood In Transition, Laura King

Vulcan Historical Review

pp. 44-54


A Structure Based Approach For Defining Ligand Interaction Requirements With Atp-Binding Cassette Proteins, Christina A. Le Jan 2019

A Structure Based Approach For Defining Ligand Interaction Requirements With Atp-Binding Cassette Proteins, Christina A. Le

All ETDs from UAB

Membrane proteins belonging to the ATP-Binding Cassette (ABC) superfamily are responsible for transporting substrates into or out of cells. ABC transporters, such as P-glycoprotein (Pgp/ABCB1) defend cells by the active efflux of many chemically diverse cytotoxic compounds. The ABC protein, CFTR/ABCC7, is a passive chloride ion channel that provides fluid homeostasis. Pgp and CFTR of are high clinical interest since mutations in CFTR can result in Cystic Fibrosis (CF) and upregulation of Pgp in tumor cells can result in multidrug resistance (MDR). There has been a major effort to develop clinical drugs to treat CF by either repairing defects in …


The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed Jan 2019

The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed

All ETDs from UAB

About 1 in 8 women will be diagnosed with breast cancer at some time in their lives, and more than 40,000 women will die due to breast cancer this year. Women do not die from localized breast cancer cases but from metastatic, or Stage IV, breast cancer (MBC). Over 150,000 women are currently living with MBC, and treatments focus on length and quality of life considering there is no cure. Triple-negative breast cancers (TNBC) do not respond to targeted therapies as they are lacking estrogen receptor alpha (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). They …


Bmp2-Derived Molecules For Increasing Osteoinductivity Of Bone Grafts To Enhance Bone Regeneration, Andrew Scott Curry Jan 2019

Bmp2-Derived Molecules For Increasing Osteoinductivity Of Bone Grafts To Enhance Bone Regeneration, Andrew Scott Curry

All ETDs from UAB

The “gold standard” of bone grafting materials is autograft. Unfortunately, autogenous bone must first be harvested from the patient, leading to complications such as donor site morbidity. Because of this, many surgeons rely on non-autogenous bone grafting materials. While these grafts are more available than autogenous bone, they require extensive processing which significantly reduces their osteoinductivity. Therefore, there is substantial interest in finding ways to add osteoinductive molecules to these grafts. Previously, our lab has focused on utilizing molecules derived from bone morphogenetic protein 2 (BMP2) with an attached hydroxyapatite-binding domain (polyglutamate) to anchor them onto bone grafting materials. Previous …


Integration Of Yeast Phenomics And Cancer Pharmacogenomics To Model Precision Medicine, Sean Santos Jan 2019

Integration Of Yeast Phenomics And Cancer Pharmacogenomics To Model Precision Medicine, Sean Santos

All ETDs from UAB

Precision medicine aims to optimize disease treatment by considering the differential influence of functional genetic variation on phenotypic outcomes and therapeutic efficacy. However, current precision medicine paradigms lack consideration of the abundance of genetic interaction and ensuing complexity of phenotypes, thus thwarting resolution of gene-drug interaction at a systems level and ‘precise’ predictions for most patients. Yeast phenomics enables quantitative, high-resolution experimental modeling of gene-drug interaction phenotypes at a systems level by measuring growth curves for the ~6000 yeast knockout/knockdown library strains, which can guide a more global resolution of disease and treatment complexity at the organism level. We postulate …


High Efficiency, Fast Dynamic Response Sc Dc-Dc Converter For Battery Management System, Ruikuan Lu Jan 2019

High Efficiency, Fast Dynamic Response Sc Dc-Dc Converter For Battery Management System, Ruikuan Lu

All ETDs from UAB

Batteries have always been considered as one of the important, reliable, light-weight, and ubiquitous energy sources in our daily lives. As battery technology has progressed, different types of battery controlling, monitoring, and supervising technologies are also being rapidly developed. Most of the modern portable electronic devices are battery-powered (lithium-ion batteries, solar cells, fuel cells, etc.). The charging and discharging of the batteries are normally based on DC-DC converter. Form converter structure, the switches and capacitors based converter without inductive components is widely applied. In addition, the switched-capacitor (SC) converters are typically integrated with a monolithic integrated circuit, the low-cost and …


Low-Cost Smart Adaptation Of Acoustic For Blood Clot Monitoring System, Hanzhi Teng Jan 2019

Low-Cost Smart Adaptation Of Acoustic For Blood Clot Monitoring System, Hanzhi Teng

All ETDs from UAB

The patented vascular access is critical for successful hemodialysis. Patients with renal failure undergoing dialysis have increased the risk of acute arteriovenous fistula (AVF) and graft (AVG) thrombosis, placing them with severe morbidity, mortality, and financial burden. In most cases, dialysis vascular access thrombosis leading to non-functional AVG/AVF occurs in a non-health environment and is usually not detected until the patient is seen at the next dialysis appointment. This leads to the loss of opportunities for early identification and timely intervention. Studies have shown that, the results of treatment are poor in patients who have undergone thrombectomy after coagulation, and …


Racial And Gender Differences In The Relationship Between Adverse Childhood Experience And Chronic Health Conditions In Adulthood, Jalal Uddin Jan 2019

Racial And Gender Differences In The Relationship Between Adverse Childhood Experience And Chronic Health Conditions In Adulthood, Jalal Uddin

All ETDs from UAB

A growing body of studies highlights that many adult diseases and health disparities in late-life are rooted in childhood adversities. However, there is little research that examines how social stratification processes structure the inequality in early-life stress exposure, and the effects of stress exposure on health outcomes may vary based on the intersections of social stratification categories. Drawing on an integrated framework of the life course stress process and intersectionality theory, this study examines the patterns in childhood adverse experiences (ACEs) by race/ethnicity and gender and how race/ethnicity, gender, and adult socioeconomic status (SES) combine to modify the effects of …


Quantifications Of Theranostic Polymer-Based Particles For Image-Guided Drug Delivery, Sithira Ratnayaka Jan 2019

Quantifications Of Theranostic Polymer-Based Particles For Image-Guided Drug Delivery, Sithira Ratnayaka

All ETDs from UAB

Modern medicine employs many drugs in its disease treatment methods. This is because they provide the best permanent solutions to complicated ailments. However the usefulness of these drugs is mitigated by several factors, namely that of specific release. Common drug delivery mechanisms lack the specificity needed to ensure that release is limited to the diseased area, which can lead to unnecessary side effects. By utilizing medical imaging, both drug delivery devices and physiology can be observed by physicians, which can greatly increase the specificity of drug delivery. Specifically, utilizing a very inert medical imaging modality, such as ultrasound, guarantees minimum …


O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman Jan 2019

O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman

All ETDs from UAB

Post translational modification of proteins plays a crucial role in regulating their function, and the role of one such modification, termed O-GlcNAcylation, is understudied. O-GlcNAcylation involves the dynamic cycle of adding and removing an O-linked N-acetylglucosamine (O-GlcNAc) by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which are highly expressed in the hippocampus. Enzymes that catalyze O-GlcNAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize to synaptosomes. We have shown that acute and selective increase in O-GlcNAcylation of AMPAR GluA2 subunits underlies expression of a novel form of LTD at CA3-CA1 synapses (O-GlcNAc LTD), as well …


Temporomandibular Joint Function After Orthognathic Surgery, Aikaterini Kleopatra Aslanidou Jan 2019

Temporomandibular Joint Function After Orthognathic Surgery, Aikaterini Kleopatra Aslanidou

All ETDs from UAB

Orthognathic surgery has 3 basic goals: function, esthetics and stability. The relationship between orthognathic surgery and temporomandibular joint function remains highly controversial. Regarding the functional changes and range of mandibular movements after surgery, mandibular hypomobility and other signs and symptoms of joint dysfunction are associated with orthognathic surgery in the literature. The aim of this study is to evaluate the function of the temporomandibular joints at lest 6 months after orthognathic surgery and compare them with non-surgical subjects. The null hypothesis is that there is no difference in subjective symptoms reported by the subjects and clinical evaluation of the range …


Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black Jan 2019

Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black

All ETDs from UAB

The kidneys are complex, multi-faceted organs that are responsible for regulatory processes, such as fluid homeostasis, hormone production, blood pressure regulation, and systemic toxin removal. Sudden disruption of these processes by acute kidney injury (AKI) causes rapid decline in renal function as well as significant morbidity and mortality. AKI is a significant clinical concern, affecting up to 13.3 million people globally each year and has the propensity to progress to chronic kidney disease (CKD), though the mechanism remains undefined. One reason for this is due to the lack of understanding of models used to study both AKI and CKD, hindering …


Dental Dimensions In Non-Syndromic Patients With Unilateral Cleft Palate, Blake Boleware Jan 2019

Dental Dimensions In Non-Syndromic Patients With Unilateral Cleft Palate, Blake Boleware

All ETDs from UAB

Objective: The main objective of this study is to determine if any difference in tooth size exists between the maxillary quadrants in non-syndromic patients with unilateral cleft palate using cone beam computed tomography. By understanding the effects of cleft palate on tooth morphology, the multidisciplinary team of specialists involved with the care and treatment of a patient with cleft lip/palate can better understand the intricacies of necessary therapy. This understanding can, in turn, be used for proper planning of desired treatments which can increase the chance of successful achievement of desired outcomes. Materials and Methods: CBCT volumes for 18 patients …