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Clinical, Radiographic, And Histomorphometric Outcomes Following Ridge Preservation Using Leukocyte- And Platelet-Rich Fibrin (L-Prf) And Freeze-Dried Bone Allograft (Fdba) Layered Technique: A Prospective, Randomized Clinical Trial, Geisy Galviz
All ETDs from UAB
Objective: The present randomized controlled clinical trial aims to evaluate clinically, radiographic, and histologically the efficacy of L-PRF in combination with FDBA either in a homogeneous mixture or using a layered technique in improving quantity and quality of new vital bone formation and alveolar ridge dimensional stability in comparison to LPRF alone for ridge preservation after tooth extraction. Materials and Methods: Twentythree patients successfully completed the study. They were randomized to receive either L-PRF/FDBA layered technique (LAY), L-PRF/FDBA homogeneous mixture (MIX), or L-PRF alone. After minimally traumatic tooth extraction, direct clinical assessment and a Cone-Beam Computed Tomography (CBCT) scan were …
How Trans Students Encounter Cisgenderism In Higher Education At The Intersection Of Location And Region: A Critical Discourse Analysis Of Trans Students' Experiences In Understudied Cities In The Southeast, Cortney Johnson
All ETDs from UAB
Despite evidence showing the resilience and success of many Transgender students in higher education and the increasing prevalence of supportive campus policies, this is an emergent population with growing, varying, and diverse needs that are often not met by institutions and practitioners. The Southeast is a unique place for the LGBTQ+ community that has been understudied, and although the experiences of Trans students and how cisgenderism impacts them has been captured more broadly, this study is focused on the experiences of Trans students at urban institutions in the Southeast. Using Critical Discourse Analysis as a methodology and Critical Trans Politics …
Implications Of Day-To-Day Oulsatility Index Change And Corticosteroid Use In Pediatric Traumatic Brain Injury, Jeremy D. Jordan
Implications Of Day-To-Day Oulsatility Index Change And Corticosteroid Use In Pediatric Traumatic Brain Injury, Jeremy D. Jordan
All ETDs from UAB
A traumatic brain injury (TBI) is a disruption of the normal function and structure of the brain after a direct or indirect injury. In children, TBI continues to be a significant cause of mortality resulting in the death of over 20 children per day in the United States (Reuter-Rice et al., 2015). Additionally, children who survive TBI have increased rates developmental delay, physical disabilities, neurologic impairment, and mental health disorders (Barlow et al., 2005). A TBI occurs in two phases. The primary injury is the physical insult to the brain that occurs at the time of the injury. The secondary …
Transcriptional Regulation And Islet Transplantation Advantages Of Brown Adipose Tissue, Jessica D. Kepple
Transcriptional Regulation And Islet Transplantation Advantages Of Brown Adipose Tissue, Jessica D. Kepple
All ETDs from UAB
Metabolic disease encompasses various disorders, including obesity and diabetes, that negatively impact glucose and lipid homeostasis and increase the risk of co-morbidities. Adipose tissue, which regulates whole-body energy balance and acts as a specialized endocrine tissue, is negatively affected by obesity and diabetes. Brown adipose tissue (BAT) functions to dissipate excess energy as heat and therefore is an attractive target against metabolic disease. To develop more effective therapeutic strategies, BAT physiology and genetic regulatory mechanisms need to be better understood. This dissertation highlights studies seeking to illuminate novel transcriptional regulation and islet transplantation applications of BAT. We investigated the requirement …
De Novo Generation Of Cardiomyocytes For Regenerative Medicine Treatment, Yawen Tang
De Novo Generation Of Cardiomyocytes For Regenerative Medicine Treatment, Yawen Tang
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Cardiovascular disease, till now, is still the leading cause of death in the United States. As a consequences of heart attack event, cardiomyocytes death is an irreversible process accompanied with scar formation and loss of heart function. As mammalian cardiomyocytes exit cell cycle shortly after birth, with no replacement of the necrotic cardiomyocytes, the damages caused by heart attack often progress into more severe symptoms such as heart failure. To replenish damaged cardiomyocytes (CMs), many therapies, such as differentiate the induced pluripotent stem cells (iPSCs) into cardiomyocytes and direct reprogram fibroblasts into CMs, have been developed. During this dissertation study, …
Glycolytic Myeloid Cells Protect The Host In Tuberculosis, Hayden Thomas Pacl
Glycolytic Myeloid Cells Protect The Host In Tuberculosis, Hayden Thomas Pacl
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Despite curative treatment, tuberculosis remains a leading cause of death around the world. As such, there is great interest in novel therapeutic approaches to treat this disease. One such approach aims to enhance the efficacy of host immune cells in responding to the pathogen, Mycobacterium tuberculosis—so called host-directed therapies. The metabolism of immune cells has been a central focus in the search for hostdirected therapies, and the role of glycolysis in myeloid cells, in particular, has received much attention. However, the role of glycolysis in myeloid cells in the context of tuberculosis has not yet been made clear. Here we …
Analysing The Contribution Of Snare-Dependent Exocytosis From Astrocytes To Huntinton's Disease Pathogenesis Using The Bachd Mouse Model, Annesha C. King
Analysing The Contribution Of Snare-Dependent Exocytosis From Astrocytes To Huntinton's Disease Pathogenesis Using The Bachd Mouse Model, Annesha C. King
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Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. Multiple studies have indicated the importance of mutant huntingtin (mHTT) in astrocytes to HD pathogenesis. Increased extracellular glutamate levels were observed after evoking SNARE-dependent exocytosis from cultured mHTT expressing astrocytes. To determine whether astrocytic SNARE-dependent exocytosis contributed to behavioral and neuropathological changes in vivo, we crossed BACHD mice to dominant negative SNARE (dnSNARE) mice and analyzed behavioral and neuropathological phenotypes. First, we found that reduc-ing astrocytic SNARE-dependent exocytosis had differential effects on the psychiatric-like and motor phenotypes observed in BACHD mice where …
The Assessment Of Neuro-Mechanics Of Inspiratory Muscles During Mechanical Ventilation, Hassan Y. Abunurah
The Assessment Of Neuro-Mechanics Of Inspiratory Muscles During Mechanical Ventilation, Hassan Y. Abunurah
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The decline in inspiratory muscles function for patients undergoing mechanical ventilation may further extend the duration of mechanical ventilation leading to lethal complications. Thus, the assessment of neuro-mechanics of inspiratory muscles may help us understand the pathophysiology for mechanical ventilation failure to avoid its complications. In this dissertation, we assessed the characteristics of inspiratory neuromechanics under different conditions. This dissertation is reported in three different papers. In the first paper, we sought to assess the quality of the available literate that used surface EMG of extra-diaphragmatic muscles during invasive mechanical ventilation. We demonstrated that the use of sEMG of extra-diaphragmatic …
From Classrooms To Polluted Communities: Scientific Inquiry In Birmingham, Alabama And Beyond, Sarah Jeanne Adkins-Jablonsky
From Classrooms To Polluted Communities: Scientific Inquiry In Birmingham, Alabama And Beyond, Sarah Jeanne Adkins-Jablonsky
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Nearly half of all U.S. students who declare science majors in college do not graduate with science degrees within six years. Improvements in science outcomes are linked with active-learning pedagogies such as Course-based Undergraduate Research Experiences (CUREs). However, despite the need for education reform particularly in Alabama, active-learning interventions are severely understudied in Alabama universities. Chapter 1 describes novel CUREs at four colleges in Birmingham, AL: The University of Alabama at Birmingham (UAB); Jefferson State Community College (JSCC), Samford University (SU), and Birmingham Southern College (BSC). Chapter 2 shows how an agar art CURE, The Art of Microbiology, impacts student …
Joint Specificity Of Stretch-Shortening Cycle Potentiation, Marzouq Khalaf Almutairi
Joint Specificity Of Stretch-Shortening Cycle Potentiation, Marzouq Khalaf Almutairi
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The stretch-shortening cycle (SSC) is a well-known phenomenon to enhance an individual’s muscular performance, and it is an area of active focus of research scientists for decades. However, it is not known whether SSC potentiation is a joint-specific event and shows a joint-specific temporal behavior. It is also unclear if constraints of joint and movement specificity of SSC potentiation can be captured via isokinetic dynamometer. Therefore, the purposes of this dissertation were to examine joint specificity of SSC potentiation via isokinetic dynamometer and kinetic-kinematic analysis of jump test performance and investigate joint-specific temporal behavior of SSC potentiation. My first study …
Effectiveness Of A University Employee Assistance Program Using The Workplace Outcome Suite And Client Satisfaction Survey, Josephine Jackson Banks
Effectiveness Of A University Employee Assistance Program Using The Workplace Outcome Suite And Client Satisfaction Survey, Josephine Jackson Banks
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Background: Gallup (2013) reported that 30% of the U.S. workforce was not engaged in their work which means they were not reaching their full potential or productivity level. For organizations, lost productivity due to absenteeism or less than ideal performance at work impacts company performance and bottom line. Employee assistance programs are a resource to help increase employee health, productivity, and satisfaction through counseling interventions. Methods: Data were collected by a large urban university EAP over a 20-month period. The analysis was limited to EAP clients over the age of 18. A total of 866 subjects participated in this study, …
External Apical Root Resorption In Asian Orthodontic Patients In Alabama, Najd Aswad
External Apical Root Resorption In Asian Orthodontic Patients In Alabama, Najd Aswad
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The main goals of orthodontic treatment are to achieve a harmonious dentalocclusion and enhance the patient’s dentofacial appearance. External Apical Root Resorption (EARR) is a side effect of orthodontic treatment1. It results in the permanent loss of tooth structure from the root apex2. EARR is a multifactorial condition which includes patient related and treatment related risk factors. Patient-related factors include genetics, severity of malocclusion, tooth-root morphology, systemic factors, density of alveolar bone, root proximity to cortical bone, previous exposure to trauma, patient age and sex. Orthodontic treatment related risk factors include treatment duration, amount of force and mechanics used, direction …
Socioeconomic Status In Adolescence And Dna Methylation In Young Adulthood, Malcolm Barker-Kamps
Socioeconomic Status In Adolescence And Dna Methylation In Young Adulthood, Malcolm Barker-Kamps
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Children from low socioeconomic status (SES) families are at a greater risk of negative health outcomes in adulthood, in part from chronic stress. The chronic stress of these experiences may become biologically embedded through DNA methylation in stress-related genes. However, the effects of specific SES dimensions during childhood or adolescence on later epigenetic profiles in adulthood are not well understood. The present study examined the roles of two objective SES dimensions and two subjective SES dimensions experienced in early adolescence in DNA methylation in young adulthood. The analyses focused on two genes, NR3C1 and SLC6A4, because their methylation has been …
Beyond Apoptosis: Insight Into The Complex Intracellular Networks That Govern Cell Fate, Hayley Neal Widden
Beyond Apoptosis: Insight Into The Complex Intracellular Networks That Govern Cell Fate, Hayley Neal Widden
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The determination of cell fate is a dynamic process regulated by hundreds of proteins that converge into complex cell signaling pathways. Upon irreparable intracellular stress, a cell undergoes programmed cell death, a process known as intrinsic apoptosis. Apoptosis is regulated by the Bcl-2 family, a class of proteins that act either as pro-survival or pro-death signaling molecules. Due to the oncogenic upregulation of pro- survival Bcl-2 family proteins across human cancer cell types, a novel class of small molecule inhibitors called ‘BH3-mimetics’ have emerged as promising anti-cancer therapeutics currently under clinical investigation. Here, we highlight the crosstalk between anti-apoptotic Bcl-2 …
Importance Of The Zebrafish Model For Understanding Nutrition, Michael Britt Williams
Importance Of The Zebrafish Model For Understanding Nutrition, Michael Britt Williams
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The common zebrafish Danio rerio is a useful model for human health. Effective utilization of this model required development of husbandry and reproductive protocols as well as genomic sequencing and creation of relevant molecular techniques. However, the dietary needs of the species remain woefully under investigated. At this time no chemically-defined open source diets are available to the zebrafish research community. Consequently, those labs utilizing the zebrafish model rely on commercial diets that may not provide adequate nutrition and lack consistency needed for rigorous and reproducible research. The first focus of these studies was to examine the current state of …
Miniaturization Of The Network Analyzer As An Interface Circuit For Wearable Resonance-Based Sensors, Fan Wu
Miniaturization Of The Network Analyzer As An Interface Circuit For Wearable Resonance-Based Sensors, Fan Wu
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Readout interface circuits are the essential part of all sensor units. Miniaturing such circuits is a challenging design issue for the future of the Internet of Things, wearable and implantable biomedical devices, sensors for harsh environments, etc. For developing wireless telemetry sensors, Vector Network Analyzer (VNA) is a powerful measurement instrument that can measure scattering parameters (S-Parameters) of single and dual-port networks, as well as Y- and Z-parameters. However, VNAs are expensive and bulky and cannot be carried around, and therefore, they can’t be used as a sensor interface. This thesis aims to design, develop, and implement a miniaturized data …
Facilitating The Transfer Of Cognitive Training To Real-World Functioning: The Transfer Package For Post-Stroke Cognitive Impairment, Jason Alexander Blake
Facilitating The Transfer Of Cognitive Training To Real-World Functioning: The Transfer Package For Post-Stroke Cognitive Impairment, Jason Alexander Blake
All ETDs from UAB
Multiple cognitive training approaches for cognitive impairment following acquired brain injury have been found to improve cognitive functioning in the laboratory setting. However, current studies suffer from a lack of focus on the transfer of improved cognitive functioning from the laboratory setting to a patient’s everyday life. This case series addresses this lack of treatment transfer using a collection of behavioral techniques known as the Transfer Package. The Transfer Package works alongside clinical and in-laboratory training of functional cognitive impairments to improve an individual’s real-world functioning and independence after injury. This cognitive training case series utilizes this Transfer Package in …
Beliefs And Intentions Of Anesthesia Physicians Toward Providing Culturally Competent Care To Transgender Patients, Erin Elizabeth Blanchard
Beliefs And Intentions Of Anesthesia Physicians Toward Providing Culturally Competent Care To Transgender Patients, Erin Elizabeth Blanchard
All ETDs from UAB
Purpose: Transgender patients face healthcare discrimination, resulting in a delay or avoidance in seeking care and increased negative health outcomes. The presence of cultural competence in patient-provider interactions has been shown to increase trust and satisfaction, resulting in better health outcomes. However, physicians receive little to no training on how to interact with transgender patients in a culturally competent manner. Anesthesia physicians often have no prior relationship with their patients and have very limited time for patient interaction before delivering care. This is why it is essential that anesthesia physicians possess the knowledge and skills to treat all types of …
Social Inclusion Among People With Mobility Limitations In The Global South, Shane Burns
Social Inclusion Among People With Mobility Limitations In The Global South, Shane Burns
All ETDs from UAB
An estimated 15% of the world’s population have a disability—roughly 80% of whom live in the Global South. People with disabilities experience profound social disparities that affect their quality of life and social inclusion. Due to the array of cultural perspectives and institutional capacities around the globe, provision of disability rights can come with its challenges. In many cultural contexts, people have moral beliefs about disability that result in shame. More medicalized beliefs toward disability are often the result of medical infrastructure that offers goods and services. Using a framework that arrays these moral and medical dimensions, I theorized that …
The Relationship Between Anosgnosia For Hemiplegia After Stroke And Fall Events In The Acute Inpatient Stroke Rehabilitation Population, Elizabeth Mosley Byrd
The Relationship Between Anosgnosia For Hemiplegia After Stroke And Fall Events In The Acute Inpatient Stroke Rehabilitation Population, Elizabeth Mosley Byrd
All ETDs from UAB
Background/Significance: Inpatient falls on acute stroke rehabilitation units remains a significant issue that negatively affects healthcare costs and causes physical and psychological injury. Prevelance of falls in the stroke rehabilitation population may be due to the presence of anosognosia for hemiplegia (AHP), which is as an unawareness of physical disability. Though the link between AHP and falls has been suggested in the literature, a formal investigation has not been conducted to address the relationship between the variables. Purpose: To explore the association between the presence of anosognosia for hemiplegia after stroke and patient fall events while admitted to an acute …
How Legitimate Companies Are Being Used For Sales For Illicit Online Products, Amanda Cetnarowski
How Legitimate Companies Are Being Used For Sales For Illicit Online Products, Amanda Cetnarowski
All ETDs from UAB
The opioid epidemic began in the early 1990s due to the misuse and misinformation of pharmaceutical opioids. Since then, the increase in opioid use ranging from hydrocodone to fentanyl has become a world-wide issue. Over time, opioid use has evolved in many ways with three major waves of opioid use beginning with oxycodone, moving to heroin, and finally to fentanyl. Usage of online platforms and forums to sell and buy illicit opioids has increased significantly due to easier internet capabilities and social media platforms. A total of 1,946 illicit online opioid sell sites were found in this study to show …
Hyperphosphatemia Contributes To Functional Iron Deficiency And Skeletal Muscle Wasting, Brian Anthony Czaya
Hyperphosphatemia Contributes To Functional Iron Deficiency And Skeletal Muscle Wasting, Brian Anthony Czaya
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Chronic kidney disease (CKD) is a global health threat that increases risk of death, which is credible to both impaired renal function and a multitude of CKD- associated comorbidities such as systemic inflammation, anemia and skeletal muscle dys- function. A distinctive feature of CKD is the dysregulation of mineral metabolism, where excess serum levels of phosphate (hyperphosphatemia) and of fibroblast growth factor 23 (FGF23) are not only viewed as biomarkers for disease severity but also exert deleterious effects towards various CKD-associated pathologies. Elevated levels of FGF23 can lead to the activation of FGF receptor 4 (FGFR4) in cell types that …
Examining The Pathophysiology Through Which Violence Exposure Varies With Functional Brain Connectivity And The Psychophysiological Response To Stress, Heather Elizabeth Dark
Examining The Pathophysiology Through Which Violence Exposure Varies With Functional Brain Connectivity And The Psychophysiological Response To Stress, Heather Elizabeth Dark
All ETDs from UAB
Violence exposure during childhood and adolescence is associated with susceptibility to internalizing disorders such as depression and anxiety. The relationship between childhood violence exposure and internalizing disorders may be explained by changes in brain function. For example, childhood maltreatment, including violence exposure, is associated with changes in brain regions that are important for emotion regulation. Reciprocal connections among these brain regions are important for healthy responses to stress. Thus, examining how childhood violence exposure varies with acute stress-induced changes in functional brain connectivity and psychophysiological stress responses may elucidate how childhood violence exposure may contribute to susceptibility to internalizing disorders. …
Targeting Oncogenic Microrna In Lung Cancer, Mackenzie Lauren Davenport
Targeting Oncogenic Microrna In Lung Cancer, Mackenzie Lauren Davenport
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Lung cancer is the leading cause of cancer-related death both in the United Statesand the world. While several genetic drivers of lung cancer have been identified, major improvements in patient outcome are lacking, highlighting the need to further understand the genetic and molecular mechanisms of this disease. The microRNA miR-31 has been implicated in oncogenesis in a variety of cancer types, and prior data from our laboratory has shown it to be overexpressed in human lung adenocarcinoma tumors compared to normal lung, high miR-31 levels correlate with decreased patient survival, and overexpression of miR-31 alone in the mouse lung epithelium …
Upregulation Of Somatostatin Receptor 2 In Neuroendocrine Tumors Using Histone Deacetylase Inhibitors, Rachael Elizabeth Guenter
Upregulation Of Somatostatin Receptor 2 In Neuroendocrine Tumors Using Histone Deacetylase Inhibitors, Rachael Elizabeth Guenter
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Neuroendocrine cancer is complex disease of the diffuse neuroendocrine system. Neuroendocrine tumors (NETs) can arise throughout the body, including the lungs and pancreas. These tumors are phenotypically and genetically heterogeneous, making accurate diagnoses difficult with current imaging standards. New diagnostic options, coupled with a better understanding of neuroendocrine cancer etiology, is urgent and necessary to provide patients with better futures. Many NETs overexpress somatostatin receptor 2 (SSTR2) on their cellular surfaces, making patients eligible for [68Ga]-DOTATATE PET/CT imaging and SSTR2-based therapies. However, patients that lack sufficient SSTR2 overexpression cannot benefit from SSTR2-targeted imaging or therapeutic options. We found that histone …
Evidence For A Bioelectrical Marker Of Insulin Resistance In Premenopausal Women: Membrane Capacitance, Valene E Garr Barry
Evidence For A Bioelectrical Marker Of Insulin Resistance In Premenopausal Women: Membrane Capacitance, Valene E Garr Barry
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Insulin resistance (IR) is associated with poor metabolic and reproductive outcomes among premenopausal women. Early identification of women with IR might mitigate these outcomes. However, clinically suitable methods to identify women with IR are unavailable due to high cost, high patient burden, or limited reliability. The objective was to examine a bioimpedance-based approach to identifying women with IR using membrane capacitance (CM). CM is a measure of cell membrane health and function, which is independently associated with IR and may be a suitable predictor. We validated the association of CM with IR and established the clinical utility of CM as …
Investigating Saudi Preschool Teachers’ Beliefs Toward Emergent Literacy Skills And Practices: A Mixed Methods Study, Fatimah Hafiz
Investigating Saudi Preschool Teachers’ Beliefs Toward Emergent Literacy Skills And Practices: A Mixed Methods Study, Fatimah Hafiz
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The current study aimed to investigate Saudi preschool teachers' beliefs about emergent literacy skills and practices. To this end, an explanatory, sequential mixed methods research design was adopted. The study involved two phases. The first involved a Q methodology approach to answer the overarching questions, "What are Saudi preschool teachers' beliefs about emergent literacy skills and practices?" and "What are the emergent literacy skills and practices that preschool teachers in Saudi Arabia consider most important for children's literacy development?" Thirty participants ranked forty statements in a quasi-normal distribution that ranged from the most important to most unimportant in relation to …
An Exploration Of The Manifestation Of Parentification Among Young Carers Of Persons With Huntington’S Disease, Bailey Hendricks
An Exploration Of The Manifestation Of Parentification Among Young Carers Of Persons With Huntington’S Disease, Bailey Hendricks
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Due to the progressive deterioration of motor, cognitive, and psychological function experienced by individuals diagnosed with Huntington’s disease, there is the potential for children in the home to adopt a caregiving role. These young carers typically serve as informal, secondary caregivers, providing multifaceted, extended care without any lessening of typical family, home, or school/work-related responsibilities. In time, this role may result in parentification, a type of role reversal with both positive and negative outcomes for the child. A secondary analysis of qualitative data of the experiences of children who have a parent with Huntington’s disease was conducted. Transcripts of qualitative …
Predictors Of Subjective And Objective Everyday Functioning In Middle-Aged And Older Adults With Hiv, Alexandra Elaine Jacob
Predictors Of Subjective And Objective Everyday Functioning In Middle-Aged And Older Adults With Hiv, Alexandra Elaine Jacob
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People with HIV (PWH) are at an increased risk for everyday functionalimpairment, especially as they age. The purpose of this study was: (1) to identify factors associated with subjective and objective instrumental activities of daily living (IADL) difficulty in PWH and (2) to identify factors associated with awareness of functional capacity. This cross-sectional study included 261 PWH. Participants completed a comprehensive neurobehavioral assessment, including self-report and performance-based measures of everyday functioning. Hierarchical multiple regressions were performed to identify health, psychological, and cognitive factors that contribute to subjective and objective evaluation of everyday functioning. We also examined factors that predicted a …
Rural And Urban Differences In Vegetable And Fruit Consumption Among Older Cancer Survivors In The Deep South: An Exploratory Cross-Sectional Study, Harleen Kaur
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Background: Rural Americans have poorer overall health and physical functioning than their urban counterparts. A varied diet, rich in vegetable and fruit (V&F) consumption may improve health; however, little is known about rural-urban differences in V&F consumption, especially in older cancer survivors. Objective: To assess differences in V&F consumption among older cancer survivors residing in urban- and rural-designated areas, and explore whether differences exist by sex, race, and cancer type. Design: This was a cross-sectional secondary analysis. Participants/setting: Screening data from the Harvest for Health trial was obtained on 731 Medicare-eligible cancer survivors across Alabama. Main outcome measures: V&F consumption …