Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Alabama at Birmingham

Discipline
Keyword
Publication Year
Publication
Publication Type

Articles 2491 - 2520 of 14457

Full-Text Articles in Entire DC Network

Alzheimer Disease Special Care Units And Nursing Homes' Organizational Performance, Giovanna Pilonieta Ortiz Jan 2022

Alzheimer Disease Special Care Units And Nursing Homes' Organizational Performance, Giovanna Pilonieta Ortiz

All ETDs from UAB

Alzheimer’s disease special care units (AD SCUs) have been adopted to provide specialized care for people with dementia in nursing homes. However, the effects of environmental and organizational factors on AD SCUs adoption by nursing homes and their influence on nursing homes' organizational performance remains unclear. Guided by Resource Dependence Theory, Donabedian’s Structure-Process-Outcome (SPO) framework and the Resource-Based View of Firms perspective, the purpose of the three papers included in this dissertation was to provide empirical evidence of the contextual and organizational factors that influence AD SCUs adoption among nursing homes and how the adoption of AD SCUs impact nursing …

Go to article

The Influence Of Sleep Duration And Sleep Efficiency On Abdominal Adiposity And Blood Pressure In Adolescents Ages 16 To 18 Who Participated In The Cleveland Children's Sleep And Health Study: A Secondary Data Analysis, Shameka Rodgers Phillips Jan 2022

The Influence Of Sleep Duration And Sleep Efficiency On Abdominal Adiposity And Blood Pressure In Adolescents Ages 16 To 18 Who Participated In The Cleveland Children's Sleep And Health Study: A Secondary Data Analysis, Shameka Rodgers Phillips

All ETDs from UAB

Introduction: Abdominal adiposity and blood pressure (BP) are two major modifiable risk factors for cardiovascular disease (CVD), the leading cause of death in the world. The impact of abdominal adiposity and BP on health, particularly CVD, begins in childhood. Older adolescents tend to have the highest prevalence of abdominal adiposity and BP in the pediatric population. Despite interventions like diet and exercise, the prevalence of excess abdominal adiposity and elevated BP continues to increase during late adolescence. Evidence suggests that sleep duration and sleep efficiency impact abdominal adiposity and BP in adults and the pediatric population, but limited studies have …

Go to article

Applying Pet Imaging To Cancer Immunotherapy To Improve Clinical Outcomes, Kirsten M. Reeves Jan 2022

Applying Pet Imaging To Cancer Immunotherapy To Improve Clinical Outcomes, Kirsten M. Reeves

All ETDs from UAB

The use of biomarkers has significantly enhanced patient outcome by improving diagnosis, personalizing therapy, and monitoring therapeutic response yet most cancers remain non-responsive. Thus, there is a need to better understand the underlying biological mechanisms and tumor microenvironment to enhance therapeutic efficacy. Molecular imaging, including magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) are used to assess response during oncology therapy. Molecular imaging can also provide a noninvasive approach to accurately quantify biomarkers correlated with the tumor microenvironment, including glucose metabolism and hypoxia. 18F-Fluoromisonidazole (18F-FMISO) hypoxia targeted cellular uptake has been shown to correlate with negative …

Go to article

Non-Mean Ambulatory Blood Pressure Monitoring Parameters And Left Ventricular Hypertrophy: Analysis Of Pooled Population- And Community-Based Studies, Swati Sakhuja Jan 2022

Non-Mean Ambulatory Blood Pressure Monitoring Parameters And Left Ventricular Hypertrophy: Analysis Of Pooled Population- And Community-Based Studies, Swati Sakhuja

All ETDs from UAB

High mean blood pressure (BP) on ambulatory BP monitoring (ABPM) is a strong risk factor for left ventricular hypertrophy (LVH), an early manifestation of hypertension-related cardiovascular disease (CVD). Typically, 48-72 systolic and diastolic BP (SBP and DBP) readings are obtained on a 24-hour ABPM recording. The large number of readings from ABPM allows for the estimation of parameters beyond mean BP that capture level and fluctuation in BP over 24-hours, which may be useful for identifying individuals at high risk for CVD. The measures of BP level other than mean BP obtained from ABPM recording include BP load (percentage of …

Go to article

Modeling Local Heat-Exposure Vulnerability And Canopy-Level Thermal Comfort In Different Urban-Vegetation Morphology, Samain Sabrin Jan 2022

Modeling Local Heat-Exposure Vulnerability And Canopy-Level Thermal Comfort In Different Urban-Vegetation Morphology, Samain Sabrin

All ETDs from UAB

Globally, most cities experience Urban Heat Islands (UHIs) phenomena which increase the heat accumulation rate within city areas compared to the suburban and rural areas. In addition, poor air quality results in a higher prevalence of heat-related mortalities-morbidities and acute respiratory diseases. Vulnerability to UHIs impacts and air pollution varying in neighborhood scale is a function of factors including temperature pattern, the concentration of major air pollutants, land surface characteristics, socioeconomic factors, vulnerable age groups, and people's susceptibility to heat and pollution. Therefore, identifying vulnerability becomes crucial to adapt to changing climate and plan for mitigation strategies. Chapter one proposes …

Go to article

The Identification And Phenotypic Characterization Of Circulating Flagellin Antigen-Specific Cd4+ T Cells In Crohn's Disease Patients, Nadine N. Morgan Jan 2022

The Identification And Phenotypic Characterization Of Circulating Flagellin Antigen-Specific Cd4+ T Cells In Crohn's Disease Patients, Nadine N. Morgan

All ETDs from UAB

The incidence of inflammatory bowel diseases (IBD) is increasing worldwide. Crohn’s disease (CD) and Ulcerative colitis (UC), the two main subtypes of IBD, are chronic intestinal conditions driven by CD4+ T-cell inflammatory responses to commensal antigen. Both conditions are incurable, and medical treatments involve drugs that require long-term usage but have limited efficacy and significant side effects. To develop therapies targeting the antigen-reactive T cells involved in sustaining these conditions, we must first gain knowledge concerning the microbial antigen-reactive T cell phenotypes and functionality in health and disease. To investigate the phenotypic and functional characteristics of the flagellin-reactive T cell …

Go to article

Disease And Diet-Induced Disruption Of Effector T Cell Homeostasis, Patrick Axel Molina Jan 2022

Disease And Diet-Induced Disruption Of Effector T Cell Homeostasis, Patrick Axel Molina

All ETDs from UAB

Homeostatic departure is a central feature across all diseases and disease processes. Currently, the average individual in the US consumes an inordinate quantity of salt. However, it is unclear if only individuals that have proven blood pressure elevation with an acute load of salt should be wary. Here we demonstrate, alongside a growing body of science, that the canonical definition of salt-sensitivity is insufficient. We show that salt-resistant mice demonstrate salt-sensitivity in non-blood pressure focused phenomena, such as the acute activation of CD4+ T cells to mobilize and induce a defective effector cytokine program with high salt. We demonstrate that …

Go to article

Influencing Factors Of Child Pedestrian Safety In Parking Lots And Residential Streets, Jenni Liveoak Jan 2022

Influencing Factors Of Child Pedestrian Safety In Parking Lots And Residential Streets, Jenni Liveoak

All ETDs from UAB

There is ample data from epidemiological sources that suggest pedestrian risks to young children are a dire public health concern. However, there is very little scientific evidence to adequately understand this concern. Two observational studies revealed potential risks to young pedestrians in non-intersection locations. Both studies unobtrusively observed children between 2-10 years of age and an accompanying adult. First, 124 adult/child dyads were observed crossing from a parked vehicle to the building entrance of six local YMCA locations. Results of this study indicate that adult supervision was inadequate with over 67% of children observed to be unsupervised in the parking …

Go to article

Tissue Engineered Cardiac Muscle Patches With Human Pluripotent Stem Cells Enhance The Repairing Efficacy Of Infarcted Cardiac Muscle In Mouse Model, Xi Lou Jan 2022

Tissue Engineered Cardiac Muscle Patches With Human Pluripotent Stem Cells Enhance The Repairing Efficacy Of Infarcted Cardiac Muscle In Mouse Model, Xi Lou

All ETDs from UAB

Myocardial infarction (MI) remains one of the major contributors to heart failure, which can lead to death, and there has been a lack of effective treatments so far. Human pluripotent stem cells (hPSCs) have been found to be an encouraging candidate for MI treatment. But it is facing challenge of low engraftment, limited integration of transplanted cells with host myocardium. To enhance the therapeutic efficacy of stem cell therapy of MI treatment, two approaches have been explored: 1)The first approach was to overexpress N-cadherin (CDH2), a cell-cell adhesion molecule, in human induced pluripotent stem cell-derived cardiomyocytes (CDH2-hiPSC-CMs), and examine its …

Go to article

Investigation Of Zinc Aluminate As A Refractory Material, Somnath Mandal Jan 2022

Investigation Of Zinc Aluminate As A Refractory Material, Somnath Mandal

All ETDs from UAB

As used chrome-based refractories may contain toxic Cr6+, the chrome-free phas-es qandilite (Mg2TiO4) and zinc aluminate (ZnAl2O4, gahnite) are being considered which are known to enhance thermomechanical properties and slag corrosion resistance. The pore generation and deleterious expansion during in situ Mg2TiO4 and ZnAl2O4 for-mation can limit their amount in a refractory composition. Hence, preformed, dense ag-gregates are desirable. Dilatometric studies revealed that when dead burned magnesia (DBM) is combined with industrial anatase instead of rutile, it expanded less (1% versus 7.2%) and the reaction occurred earlier (965℃ compared to 1120℃). The anatase-based qandilite aggregate had 0% porosity and a …

Go to article

Regulation Of Stromal Cells Through Inflammatory Signalling, Victoria Matkins Jan 2022

Regulation Of Stromal Cells Through Inflammatory Signalling, Victoria Matkins

All ETDs from UAB

The bone marrow is a complex organization of hematopoietic and nonhematopoietic cells that form niches to maintain systemic homeostasis during stress and disease. Stromal cells are non-hematopoietic cells first proposed in 1978 in the bone marrow to be essential for hematopoietic stem cells (HSC). Since then, mesenchymal stromal cells (MSC) have been shown to be critical for the HSC self-renewal, retention, and differentiation through chemokines, cytokines, and adhesion molecules. However, like HSCs, MSCs are multipotent progenitors that differentiate into osteoblasts, adipocytes, and chondrocytes to from tissues of the skeletal, endocrine, and connective systems. These multipotent progenitors are tightly regulated in …

Go to article

Power And Sample Size Calculations For Linear Mixed Models Of Longitudinal Data Using The Kenward-Roger Adjusted Wald Test, Tarrant Oliver Mcpherson Jan 2022

Power And Sample Size Calculations For Linear Mixed Models Of Longitudinal Data Using The Kenward-Roger Adjusted Wald Test, Tarrant Oliver Mcpherson

All ETDs from UAB

The linear mixed model has become a popular technique for the analysis of longitudinal data, but Wald test statistics of fixed effects for these models frequently lack well defined distributions. A common approach to this problem uses the Kenward-Roger adjustment, which attempts to approximate the distribution of the Wald statistic by matching its moments obtained via Taylor expansion to those of an F distribution. However, this approach only matches moments obtained under the null hypothesis of no effect and cannot currently be used to approximate the distribution of the test statistic under some alternative hypothesis. This limitation prevents a straightforward …

Go to article

Role Of Electrophysiological Markers In Cognition In Parkinson's Disease, Adeel A. Memon Jan 2022

Role Of Electrophysiological Markers In Cognition In Parkinson's Disease, Adeel A. Memon

All ETDs from UAB

Parkinson's disease (PD) is more than a movement disorder, and non-motor symptoms, including cognitive deficits and sleep disorders, present early and adversely affect the quality of life of a person with Parkinson's disease (PwP). Unfortunately, no pharmacological therapies slow or halt the progression of cognitive decline in PD. A substantial obstacle to developing effective cognitive therapies is the heterogeneous cognitive profile in PD, as well as a lack of a reliable biomarker of cognitive impairment. Moreover, the ideal biomarker would be generalizable, widely accessible, easily measured, non-invasive, and, ideally, modifiable. Unfortunately, thus far, proposed markers of cognitive deficits often include …

Go to article

Exploring The Relationship Between Chronic Stressors And Protective Factors And Preterm Risk In An African American Pregnant Population, Megan Mileski Jan 2022

Exploring The Relationship Between Chronic Stressors And Protective Factors And Preterm Risk In An African American Pregnant Population, Megan Mileski

All ETDs from UAB

BACKGROUND: In the United States, infant mortality is a serious public health issue, particularly for the African American (AA) population. Despite ample research investigating explanations for the significantly higher infant mortality rate (IMR) for AA infants in the United States, the reason for the racial disparity remains unknown. Reports suggest that chronic, life-course stressors may increase risk of preterm birth (PTB), the leading contributor to the high IMR for AA infants. Adverse childhood experiences and perceived racial discrimination, experienced over the life course, have the potential to increase a stress response in AA women, leading to PTB. Psychosocial resources may …

Go to article

Roles Of Chemokine Receptors In T Cell Accmulation In Omental Tumors, Mingyong Liu Jan 2022

Roles Of Chemokine Receptors In T Cell Accmulation In Omental Tumors, Mingyong Liu

All ETDs from UAB

The omentum is an adipose tissue in the peritoneal cavity that contains immune aggregates termed milky spots. Functionally similar to conventional lymphoid tissues, these specialized leukocyte clusters harbor effector and suppressor cells, mount immune responses to antigens, and sustain peritoneal homeostasis. However, the pre-existing leukocytes fail to protect the tissue from tumor colonization. In fact, the omentum is frequently involved in peritoneal metastasis, during which the balance between effector and suppressor immune cells is compromised with the latter gaining dominance. Regulatory T cells (Tregs) represent a major immunosuppressive population in the omentum and rapidly accumulate after tumor implantation. The increased …

Go to article

Elucidating Pgc-1Α And Errγ Gene Regulation In Neurons, Kathlene Lanphear Joyce Jan 2022

Elucidating Pgc-1Α And Errγ Gene Regulation In Neurons, Kathlene Lanphear Joyce

All ETDs from UAB

Neuronal energy production is critical to the function of the entire central nervous system. Without enough ATP, neurons are not able to maintain their synaptic structure or activity, leading to a circuit-wide dysregulation, affecting movement and memory. The main process for ATP production in neurons is oxidative phosphorylation, which is supported by several proteins encoded by nuclear DNA. Transcription of nuclear DNA is regulated by DNA-binding transcription factors and co-activators which recruit other members of the transcription initiation complex to induce gene expression. While important basally, during neurodegenerative diseases such as Parkinson’s Disease, the transcription of these genes is altered …

Go to article

Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman Jan 2022

Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman

All ETDs from UAB

Introduction: Chlamydia is the most common bacterial sexually transmitted infection (STI) worldwide and it disproportionally affects young people and those living in the Southern United States. If left untreated chlamydia infections can lead to complications such as infertility and pelvic inflammatory disease. Currently, chlamydia vaccines are being development. A successful chlamydia immunization program would require adolescents to be vaccinated before engagement in sexual activity and would require parental approval and recommendations from healthcare providers. Therefore, this project aims to explore parent and healthcare provider opinions about chlamydia vaccines to identify potential barriers and facilitators to uptake. Because the COVID-19 pandemic …

Go to article

Characterizing The Role Of Tissue-Specific Retinol Dehydrogenases, Kelli Rae Goggans Jan 2022

Characterizing The Role Of Tissue-Specific Retinol Dehydrogenases, Kelli Rae Goggans

All ETDs from UAB

The bioactive form of vitamin A, retinoic acid is essential for development, cellular differentiation, epigenetic modifications, the immune system, and a variety of other processes due to its ability to regulate over 500 genes through activation of nuclear receptors. While many studies have focused on characterizing the biosynthesis and signaling of retinoic acid in embryogenesis, few have focused on adult tissues. Recent research has identified a novel retinol dehydrogenase, retinol dehydrogenase epidermal 2 (RDHE2), and shown RDHE2 is a potent, physiologically relevant retinol dehydrogenase in Xenopus. The work in this dissertation characterizes RDHE2 in mammalian models. We identify a paralog …

Go to article

Shifting The Narrative: Resources Promoting Positive Parenting Independent Of Abuse Risk, Samantha Gonzalez Jan 2022

Shifting The Narrative: Resources Promoting Positive Parenting Independent Of Abuse Risk, Samantha Gonzalez

All ETDs from UAB

Parenting is exceptionally influential during the first few years of children’s lives as this stage represents a sensitive developmental period. Quality of parenting is particularly important and the current empirical focus on prediction of at-risk parenting does not capture the full picture of what contributes to children’s and families’ well-being. Greater understanding of maternal and paternal positive parenting and its contributors—including a focus on potential protective factors to serve as resources—is essential to move family science more reliably toward a model of prevention of adverse outcomes rather than solely intervention. Furthermore, the field continues to be dominated by self-report methods …

Go to article

Transcriptional Regulation Of Metabolism And Synaptic Function In Neurons, Stephanie N. Fox Jan 2022

Transcriptional Regulation Of Metabolism And Synaptic Function In Neurons, Stephanie N. Fox

All ETDs from UAB

Mitochondrial dysfunction, transcriptional dysregulation, and protein aggregation are all unifying features of neurodegenerative disorders, including Parkinson’s Disease. Parkinson’s Disease is a debilitating movement disorder with no known cure, leading sci-entists to explore the underlying etiological contributors to neuronal dysfunction and loss to devise strategies for neuroprotection. Estrogen-related receptor gamma (ERRγ) is a member of a family of transcription factors which regulate the expression of mitochondrial genes. To determine whether ERRγ modulation can provide insight into transcriptional and mitochondrial dysfunction with neurodegeneration, the experiments in this thesis project determined 1) the importance of transcription of mitochondrial genes in disease as regu-lated …

Go to article

Epigenetic Regulation Of Gene Expression In Temporal Lobe Epilepsy, Rebecca Mary Hauser Jan 2022

Epigenetic Regulation Of Gene Expression In Temporal Lobe Epilepsy, Rebecca Mary Hauser

All ETDs from UAB

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and is characterized by seizures originating from the temporal lobe of the brain. A frequent seizure focus in TLE is the hippocampus, a structure located within the temporal lobe crucial for its role in memory formation. Seizures are an excess of synchronous excitation in the brain caused by a surplus of excitatory neurotransmission and a lack of sufficient inhibitory transmission. Coordinating the process of neuronal transmission is differential expression of genes likely resulting in an increase or decrease in proteins responsible for neural signaling such as neurotransmitters, ion …

Go to article

Oxygen Cost Of Walking And Its Correlates In Multiple Sclerosis, Brenda Jeng Jan 2022

Oxygen Cost Of Walking And Its Correlates In Multiple Sclerosis, Brenda Jeng

All ETDs from UAB

Multiple sclerosis (MS) is a chronic, neurological disease characterized by demyelination and transection of axons as well as loss of neurons in the central nervous system that may result in poor walking efficiency, indicated by an increase in the oxygen cost of walking (Cw). The Cw is defined as the amount of oxygen consumed per kilogram of body weight per unit distance walked and reflects disability-related gait abnormalities and manifestations and its interaction with the environment. This dissertation involved four research projects. The first project provided an overview of existing research on the Cw in MS and established a research …

Go to article

Il-2-Mediated Stat3 Activation Controls Effector T Regulatory Cell Development, Emma C. Dean Jan 2022

Il-2-Mediated Stat3 Activation Controls Effector T Regulatory Cell Development, Emma C. Dean

All ETDs from UAB

Heterogeneity in phenotype and function of Treg cells is becoming increasingly appreciated, especially in the context of creating potent Treg cell–based therapeutics in the treatment of inflammatory bowel disease. One of the barriers to developing such therapeutics is the limited understanding of the signals that play a role in the development of Treg cell subsets. Here, we found STAT3 signaling to be enriched in induced IL-10 competent Treg (iTreg) cells in the colon. Through the development of a new in vitro system, we found that STAT3 was required for proper development of IL-10 competent iTreg cells and that IL-2 regulated …

Go to article

Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer Jan 2022

Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer

All ETDs from UAB

Osteoarthritis (OA) is a debilitating, inflammatory, joint degeneration disorder, and is the most common form of arthritis. Individuals reaching end-stage OA often pursue elective total hip/knee arthroplasty (THA/TKA) to relieve pain and improve mobility and quality of life. However, approximately one third of THA/TKA patients suffer long-term mobility impairments following surgery, likely in part due to an inability to repair the damaged muscle surrounding the diseased joint. Mechanisms driving this impaired recovery remain poorly understood, therefore it is prudent to interrogate the molecular signatures in skeletal muscle at the time of surgery to provide candidate markers that may improve upon …

Go to article

Examining Urban Teachers' Perceptions And Practices Of Family Literacy Partnerships In Schools, Homes, And Communities: A Case Study, Andrea M. Dailey Jan 2022

Examining Urban Teachers' Perceptions And Practices Of Family Literacy Partnerships In Schools, Homes, And Communities: A Case Study, Andrea M. Dailey

All ETDs from UAB

This qualitative case study examined urban teachers' perceptions and experiences of family literacy practices and partnerships in urban schools, homes, and communities during remote learning. Research shows that collaboration among schools, families, and communities can help improve overall educational outcomes and literacy development of children from linguistic and low socioeconomic backgrounds (Curry et al., 2016; Henderson & Mapp, 2002; Taylor, 1989). However, there is limited research on family literacy practices and partnerships in urban settings during remote learning. Therefore, this research explores family literacy practices and partnerships between schools, families, and communities in urban environments to help improve students' literacy …

Go to article

Molecular And Cellular Mechanisms Of Resistance Training-Induced Skeletal Muscle Hypertrophic Response Heterogeneity In Older Adults, Margaret Bell Jan 2022

Molecular And Cellular Mechanisms Of Resistance Training-Induced Skeletal Muscle Hypertrophic Response Heterogeneity In Older Adults, Margaret Bell

All ETDs from UAB

Sarcopenia is a decrease in skeletal muscle (SKM) mass occurring with age. This disease is natural, so it is important to increase SKM mass to counteract. This need is seen in diseases leading to muscle atrophy (i.e., insulin resistance and diabetes). The most efficient way to promote SKM hypertrophy is resistance exercise training (RT), however there is high response heterogeneity. To investigate SKM heterogeneity and maximizing SKM hypertrophy, we conducted a double-blind two-site placebo controlled clinical trial: “Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)”. Here participants > 65 years underwent RT for 14 weeks. Measurements of SKM mass …

Go to article

The Role Of Mitochondrial Genetic Background In Cellular Function, Response To Cell Stress And Disease Susceptability, Jamelle A. Brown Jan 2022

The Role Of Mitochondrial Genetic Background In Cellular Function, Response To Cell Stress And Disease Susceptability, Jamelle A. Brown

All ETDs from UAB

There is a differential susceptibility associated with several diseases including cardiovascular disease (CVD) and hypertension, with Blacks being more likely to develop these conditions. Blacks are also more likely to die from these diseases. To explain the genetic etiology underlying CVD pathogenesis, the primary focus has been on nuclear genetics-environmental interactions, whereas the contribution of mitochondrial genetics is less explored. Therefore, we sought to determine whether differences exist in cellular function and response to cell stress in healthy and diseased individuals with distinct mitochondrial genetic backgrounds. To determine this, we sought first to develop a technique to detect and quantify …

Go to article

Evaluation And Revision Of The Practice Environment Scale Of The Nursing Work Index For Acute Care Hospital Staff Nurses, Caitlin Marley Campbell Jan 2022

Evaluation And Revision Of The Practice Environment Scale Of The Nursing Work Index For Acute Care Hospital Staff Nurses, Caitlin Marley Campbell

All ETDs from UAB

The Practice Environment Scale of the Nursing Work Index (PES-NWI) is the most frequently used instrument for measuring the nursing work environment. The original PES-NWI obtained its items directly from the parent instrument, the Nursing Work Index, which was developed in the 1980s. However, potential value change among younger generations and vast historical, social, and technological transformations in the way healthcare is provided may have led to different factors that compose a favorable work environment for nurses working today. The purpose of this dissertation was to evaluate and revise the PES-NWI for use in today’s nursing workforce. To accomplish this …

Go to article

History Of Allergy, Atopy, Infectious And Autoimmune Disease And Risk Of Multiple Myeloma, Tony B. Zbysinski Jan 2022

History Of Allergy, Atopy, Infectious And Autoimmune Disease And Risk Of Multiple Myeloma, Tony B. Zbysinski

All ETDs from UAB

Multiple Myeloma (MM) is a plasma cell malignancy, which is defined in part by antibodies and complexes of immunoglobulin (Ig) heavy and light chains (IgH and IgL). Previous associations of immune-stimulating conditions such as allergic, autoimmune, and infectious conditions and the risk of multiple myeloma (MM) are inconsistent. However, these studies were conducted in populations of European ancestry, leaving the possibility that these conditions may contribute to the excess risk of plasma cell proliferative disorders observed among Black Americans. Therefore, we assessed MGUS, a precursor condition to myeloma, and MM risk related to a history of allergy, atopy, infections and …

Go to article

Epigenetic Regulation By O-Glcnac Alters Anti-Fibrotic Gene Expression In Ipf Fibroblasts, Qiuming Wu Jan 2022

Epigenetic Regulation By O-Glcnac Alters Anti-Fibrotic Gene Expression In Ipf Fibroblasts, Qiuming Wu

All ETDs from UAB

Idiopathic pulmonary fibrosis (IPF) is an age-related chronic disease with a me-dian survival period of 3-4 years [1]. Although FDA has approved two drugs that may slow the disease process, there is no effective treatment [2]. IPF is characterized by the excessive deposition of collagen, which leads to deformation of alveolar structure, loss of lung function, and ultimately death [3]. Anti-fibrotic genes such as cyclooxygenase-2 (COX-2) and Heme Oxygenase 1 (HMOX-1) are usually suppressed in the pathogenesis of IPF [4-6], while the mechanisms responsible for the repression of anti-fibrotic genes in IPF are incompletely understood. More evidence has shown that …

Go to article

First Prev Next Last