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Diagnostic Electrophysiology Of The Eye, Brooke Nicole Conner-Tsang
Diagnostic Electrophysiology Of The Eye, Brooke Nicole Conner-Tsang
All ETDs from UAB
Aging and age-related changes in the brain are known to parallel functional and anatomical changes in the eye, especially in certain degenerative diseases. This study explores the potential of combining ERG, specifically the Pattern Electroretinogram (PERG), which has a black and white checkerboard pattern, and OCT tests to monitor retinal ganglion cell health. We compared ERG and OCT findings from ten normal females, ages ranging from 18 to 30 years old to ascertain if ganglion cell layer volume is a reliable indicator of ganglion cell function as measured by ERG. Our results from these healthy subjects will serve as prelude …
Use Of Force By Correctional Officers: A Test Of General Strain And Scial Bond Theories, Benjamin Hixon
Use Of Force By Correctional Officers: A Test Of General Strain And Scial Bond Theories, Benjamin Hixon
All ETDs from UAB
Use of force in corrections is significantly less studied when compared to other fields, such as policing. This is a problem as unnecessary and unjustified use of force in corrections needlessly raises the violence level in correctional facilities, which endangers persons in custody and correctional officers alike. The current study examines use of force in corrections using a theoretical approach. First, Robert Agnew’s general strain theory is applied to understand use of force encounters between persons in custody and correctional officers. Second, Travis Hirschi’s social bond theory is used to investigate whether certain social bonds may relate to reductions in …
Intracerebral Hemorrhage Hospitalizations And Outcomes: Comparisons Between Institutional And National Data, Zhuobin Huang
Intracerebral Hemorrhage Hospitalizations And Outcomes: Comparisons Between Institutional And National Data, Zhuobin Huang
All ETDs from UAB
Intracerebral hemorrhage (ICH) is associated with a high risk of in-hospital mortality therefore we decided to define the effect of procedures and other risk factors on in-hospital mortality among different regions in the US. South and UAB Hospital. We used 2 datasets, the University of Alabama at Birmingham Hospital data and the National Inpatient Sample (NIS). We included 425 patients with a diagnosis of intracerebral hemorrhage over 18 years of age from the UAB Hospital stroke registry between 2016 to 2019; in NIS between 2016 to 2018, 68525 patients age 18 or above met inclusion criteria selected by International Classification …
A 15-Year Retrospective Analysis On After-Hours Dental Emergencies In A Children's Hospital Setting, Alexandra An-Yen Chen
A 15-Year Retrospective Analysis On After-Hours Dental Emergencies In A Children's Hospital Setting, Alexandra An-Yen Chen
All ETDs from UAB
Dental emergencies are one of the most common oral health complications and can exhibit a detrimental impact on a child’s physical and psychological development; additionally, it may impose economic challenges for the family. Purpose: The purpose of this study was to analyze the after-hours dental emergency visits in the past 15 years at the Children’s of Alabama (COA) Hospital Emergency Department. Methods: A retrospective chart review between January 2007 and December 2021 was conducted. Patients’ demographics, type of dental complaint, and management were evaluated for overall characteristics in the 15 years and trends in 5-year increments. The impact of the …
Correlates Of Early Adversity In Children And Adolescents: Examining The Interrelatedness Of Aggression, Post-Traumatic Stress, And Suicidal Behaviors, Elizabeth Mcrae
Correlates Of Early Adversity In Children And Adolescents: Examining The Interrelatedness Of Aggression, Post-Traumatic Stress, And Suicidal Behaviors, Elizabeth Mcrae
All ETDs from UAB
The negative outcomes associated with adverse childhood experiences, especially child maltreatment ACEs (CM-ACEs), often emerge concomitantly with these experiences and have cascading negative effects across the lifespan. For example,childhood aggression, post-traumatic stress, and suicidal behaviors have all been identified as negative sequelae of CM-ACEs. They have been associated with each other, as well, and share several common underlying mechanisms. Thus, it might be that these outcomes collectively exacerbate the risk of experiencing negative effects of CM-ACEs, yet most existing research has examined these risk factors independently. Moreover, these outcomes often emerge early in development, yet most related research has been …
Nox2-Derived Superoxide And Mda5-Dependant Responses Contribute To Autoimmune Diabetes, Samuel Isaac Blum
Nox2-Derived Superoxide And Mda5-Dependant Responses Contribute To Autoimmune Diabetes, Samuel Isaac Blum
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NADPH oxidase 2 (NOX2)-derived superoxide, a precursor for many reactive oxygen species (ROS), regulates cell signaling, cellular trafficking, melanoma differentiation-associated protein 5 (MDA5) responses, and Type 1 diabetes (T1D). Previously, we demonstrated that NOX2-derived superoxide promotes chemokine synthesis, spontaneous and virus-accelerated T1D, and MDA5 responses to coxsackievirus B3 (CVB3), an associated environmental trigger for T1D. Yet, it remains unknown if ROS is necessary for diabetogenic T cell trafficking into islets or how MDA5 responses affect T1D. First, using non-obese diabetic (NOD) mice that contain an in-frame deletion within the helicase 1 domain of MDA5 (ΔHel1) or lack MDA5 expression (KO), …
Changes In Pain Intensity And Physical Activity Levels In Individuals With Acetabular Dysplasia Undergoing Periacetabular Osteotomy: A Longitudinal Cohort Study, Naif Z. Alrashdi
Changes In Pain Intensity And Physical Activity Levels In Individuals With Acetabular Dysplasia Undergoing Periacetabular Osteotomy: A Longitudinal Cohort Study, Naif Z. Alrashdi
All ETDs from UAB
Acetabular dysplasia (AD) is a condition of the hip joint that is characterized by incomplete acetabulum development leading to lack of bony coverage of the femoral head. As a result of intra-articular injury from lack of bony congruency, often, individuals with AD report hip joint instability, pain, decreased hip-related function, and are at high risk for early development of hip osteoarthritis (OA). AD is primarily affects young-to-middle-aged adults, is more common in females and those with history of a breech birth position. Periacetabular osteotomy (PAO) is the currently-recommended surgical treatment for AD that aims to reposition the acetabulum to increase …
A Pilot Mixed Methods Study Examining Factors Affecting Return To Work Among African American Stroke Survivors, Kristin D. Ashley
A Pilot Mixed Methods Study Examining Factors Affecting Return To Work Among African American Stroke Survivors, Kristin D. Ashley
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BACKGROUND: Stroke is a highly prevalent and disabling condition among African Americans. Although there is limited research regarding barriers and facilitators to return to work among stroke survivors, evidence suggests that African American stroke survivors return to work (RTW) less frequently than Caucasians. Most of the research on this topic has been conducted in European countries, leaving significant knowledge gaps on RTW among African Americans in the United States. The purpose of this study was to identify factors that affect RTW for African American stroke survivors and then build upon those results to better understand facilitators and barriers to RTW. …
The Relationship Between State Level Funding, Designated Trauma Centers, And Trauma Related Morbidity, Ginger Henry
The Relationship Between State Level Funding, Designated Trauma Centers, And Trauma Related Morbidity, Ginger Henry
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This study examined the relationship of funding and the number of designated trauma centers and age-adjusted trauma mortality across the 50 states. State level funding was defined as monies that were paid to the designated trauma hospitals in aggregate by state and by year for the years 2008 to 2017. The number of designated trauma hospitals were considered in the categories of total number of state trauma hospitals and designation levels 1 through 4. Age-adjusted mortality included the ICD-10 codes for trauma from the WISQARS database. The strategic adaptation theory was used to inform the trauma hospital manager’s need to …
Mice With Ghrh Deficiency Are Resistant To The Detrimental Health Effects Of High Fat Diet, Joseph Jablonsky
Mice With Ghrh Deficiency Are Resistant To The Detrimental Health Effects Of High Fat Diet, Joseph Jablonsky
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According to our previous study, mice with a CRISPR/Cas9 mediated deletion of the GHRH gene have decreased bodyweight, respiratory exchange ratio (RER), energy expenditure compared to wild type animals, and increased insulin sensitivity and enhanced longevity. Calorie restriction enhances lifespan and delays multiple aging related phenotypes; however it is not known how these animals respond to nutritional stressors such as high fat diet (HFD) during the aging process. We subjected 18 month old GHRH-/- male and female mice to a high fat diet to determine differences in response to HFD in aged animals. After HFD exposure, GHRH-/- mice have increased …
Spike-And-Slab Additive Models And Scalable Algorithms For High Dimensional Data Analysis, Boyi Guo
Spike-And-Slab Additive Models And Scalable Algorithms For High Dimensional Data Analysis, Boyi Guo
All ETDs from UAB
There are proposals that extend classical additive models (AMs) to accommodate high-dimensional data (p >> n) using group sparse regularization. However, the sparse regularization may induce excess shrinkage when estimating smooth functions, damaging predictive performance. Moreover, most of these AMs consider an “all-in-allout” approach for functional selection, rendering them difficult to answer if nonlinear effects are necessary. While some Bayesian models can address these shortcomings, model fitting can create a new challenge, scalability. In this dissertation, we propose Bayesian hierarchical additive models to address the previous shortcomings: we consider the smoothing penalty for proper shrinkage of curve interpolation via reparameterization. A …
Three Essays On Federally Qualified Health Centers: Competition, Patient-Centered Medical Home Adoption, Quality Quartiles Ranking And Financial Performance, Hani Al-Maliki
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he following three essays examine the Federally Qualified Health Center (FQHC) industry. The first essay attempts to provide a description on what constitutes a competitive environment for FQHCs located in California, the second explores the impact of FQHC market competition on Patient Centered Medical Home (PCMH) adoption, and the third essay aims to test the relationship between the adoption of PCMH and FQHCs’ performance. The first essay utilizes Porter's Five Forces model to identify competitive forces in the FQHCs environment to fill a gap in the literature. Building on the first essay, the second essay using Porter’s generic strategies explores …
A Population-Based Assessment Of Severe Maternal Morbidity Among Non-Hispanic Black Women In The United States, Lisa R. Allen
A Population-Based Assessment Of Severe Maternal Morbidity Among Non-Hispanic Black Women In The United States, Lisa R. Allen
All ETDs from UAB
Non-Hispanic Black women (Black women) are disproportionately affected by adverse maternal health outcomes as compared to women of other races. Little is known about the distribution of adverse maternal health outcomes among Black women. Using the 2014 National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality (AHRQ), a nationally representative sample of hospital discharges in the United States (U.S.) from January 1 through December 31, 2014, we examined severe maternal morbidity (SMM) experienced during delivery hospitalization among Black women. We conducted population-based, cross-sectional studies to examine the distribution of SMM prevalence; assess within-race …
A Framework For Enterprise Systems Based On Process Improvement, Abdulrahman Alharthi
A Framework For Enterprise Systems Based On Process Improvement, Abdulrahman Alharthi
All ETDs from UAB
We introduce a framework for enterprise systems based on process-centered analysis. Because technology has drastically altered many aspects of our lives, such as work, leisure, travel, government, and company interactions worldwide, companies must strategically consider the Internet of Things in order to thrive in the new economy. Tanik and Jololian offered early work in this area, and included an analysis of the T-Strategy introduced by R.T. Yeh et al. in their book “Zero-time.” Our approach builds on this decade-old work, and involves the introduction of information flow analysis to process improvement [1]. We have identified two key points: centralization and …
A Framework For Designing Blockchain Systems In A Smart City Setting, Mohammad Alhefdi
A Framework For Designing Blockchain Systems In A Smart City Setting, Mohammad Alhefdi
All ETDs from UAB
As main characteristics of successful smart cities, the high demand for increased data security and accessibility and citizen engagement mean the role of blockchain technology has begun to increase. Nonetheless, blockchain technology also faces several challenges, which have slowed its adoption. In response, this dissertation introduces a framework for designing blockchain systems in a smart city setting and considers the smart city and blockchain challenges. Researchers have proposed several smart city models that study and analyze the complexity of smart cities to improve city security, functionality, services, and smartness. The proposed information-theoretical modeling approach to generate an innovated blockchain model …
Teaching Economic Values: A Mixed Methods Study Of Kindergarten Curricula, Values, Practices, And Teachers' Perspectives In Saudi Arabia, Hanaa Abualsoud
Teaching Economic Values: A Mixed Methods Study Of Kindergarten Curricula, Values, Practices, And Teachers' Perspectives In Saudi Arabia, Hanaa Abualsoud
All ETDs from UAB
The primary purpose of this study was to investigate Saudi teachers' practices in developing economic values for kindergarten children, in Eastern region (Qatif city). The researcher also looked at teachers' awareness of Saudi Vision 2030 educational goals. The research was conducted using a convergent mixed methods design. In the quantitative strand, data was collected from 263 teachers using questionnaires. Data was collected from seven knowledgeable teachers using semi-structured interviews in the qualitative strand. The qualitative and quantitative data were analyzed independently through content analysis for the qualitative data and a Google Forms for quantitative data. Results from both strands were …
Teacher Perception, Experience, And Attitudes On Student Achievement In A Title I High School In Central Alabama, Marvin Augusta Carter
Teacher Perception, Experience, And Attitudes On Student Achievement In A Title I High School In Central Alabama, Marvin Augusta Carter
All ETDs from UAB
The purpose of this study was to share the lived experiences of teachers regarding how they supported student achievement in a Title I high school. After almost 60 years of Title I initiatives, the achievement gap between students in poverty and other more affluent students has not changed in any statistically significant manner (Jimenez-Castellanos, 2010). Due to the lack of academic growth for students in Title I schools as compared to students in non-Title I schools, parents, policymakers, and other stakeholders have increased pressure on educators and educational researchers to identify student achievement barriers and implement the use of effective …
The Relationship Between Nurse And Therapy Staffing Levels And The Medicare Patient-Driven Payment Model Reimbursement During The Covid-19 Pandemic, Roland T. Shapley
The Relationship Between Nurse And Therapy Staffing Levels And The Medicare Patient-Driven Payment Model Reimbursement During The Covid-19 Pandemic, Roland T. Shapley
All ETDs from UAB
The Patient Driven Payment Model (PDPM) brought about a paradigm shift in the way skilled nursing facilities are reimbursed, by linking complexity of care to beneficiary need, expanding case-mix adjusted components by including a non-therapy ancillary and speech language pathology component, and limiting the volume of therapy services provided. The COVID-19 pandemic wreaked havoc upon the nursing home industry that gave rise to high patient and staff infections and fatalities, declining occupancy rates, and nursing shortages, compelling the Department of Health and Human Services to provide $4.9 billion in CARES Funding to skilled nursing facilities (SNFs). Using Payroll Based Journal, …
Shared Savings Bonus In Mssp And Its Association With Length Of Participation, Terry D. Knight
Shared Savings Bonus In Mssp And Its Association With Length Of Participation, Terry D. Knight
All ETDs from UAB
Accountable Care Organizations (ACOs) are integrated groups of providers responsible for reducing cost and improving quality for a group of individuals. Medicare began using these organizations in 2012, after the passage of the Affordable Care Act (ACA), to move away from traditional fee-for-service reimbursement. This alternative payment model is the Medicare Shared Savings Program (MSSP). MSSP affords ACOs the opportunity to receive a portion of the savings they achieve if specific cost targets and quality benchmarks are met. Length of participation time in the alternative payment model may increase the ACOs’ ability to achieve savings. The analysis of MSSP savings …
Applying The Hospitalist Model Of Care To Cardiovascular Acute Care Delivery, Ginger K. Biesbrock
Applying The Hospitalist Model Of Care To Cardiovascular Acute Care Delivery, Ginger K. Biesbrock
All ETDs from UAB
The hospitalist model for managing patients in the hospital setting has been in existence for over 20 years. The hospitalist model for non-specialty care has been found to improve the efficiency of care, maintain quality of care, and support a higher degree of guideline adherence. However, there has been little research focusing on the use of the hospitalist model for specialty care. As cardiovascular programs have begun to adopt the hospitalist model, many are asking if this model is more effective than the traditional model. The main concern is the potential disruption to the patient-physician relationship that occurs with the …
The Impact Of The Covid-19 Pandemic On College Students With Disabilities Or Pre-Existing Conditions: A Qualitative Dissertation, Caro Celestine Holmes Wolfner
The Impact Of The Covid-19 Pandemic On College Students With Disabilities Or Pre-Existing Conditions: A Qualitative Dissertation, Caro Celestine Holmes Wolfner
All ETDs from UAB
The COVID-19 pandemic continues to have a global and multifaceted impact on public health. The onset of the pandemic has resulted in widespread campus closures and transitions from in-person classes to online learning, further exacerbating the mental health crisis brought about by the pandemic. The effects of federal and state regulations have influenced the psychological well-being and mental health of many, more notably for college students with disabilities or pre-existing conditions. However, COVID-19 research on college students with disabilities or pre-existing conditions is limited and mostly international, thus it is of great importance to address these limitations. This phenomenological study …
Analysing The Structural Dynamics Of Retinoid X Receptor Using Hydrogen Deuterium Exchange Mass Spectrometry, Nathalia Melo
Analysing The Structural Dynamics Of Retinoid X Receptor Using Hydrogen Deuterium Exchange Mass Spectrometry, Nathalia Melo
All ETDs from UAB
Nuclear receptors (NR) are ligand-activated transcription factors that are targets for drug discovery due to their ability to directly modulate gene expression. There are 48 NRs and approximately half of them require heterodimerization with retinoid X receptor (RXR) to function. Targretin (bexarotene) is an FDA-approved RXR specific (rexinoid) currently used to treat Cutaneous T-cell Lymphoma (CTCL); however, it causes hyperlipidemia toxicities. A functionally similar rexinoid developed at UAB, 9-cis-UAB30 (UAB30), is non-toxic and weak agonist in the liver. While UAB30 shows promise as a low toxicity chemopreventative drug, the mechanism of UAB30 action at the molecular level is poorly understood. …
Elucidating The Role Of Stat4 In Cd4 T Cell Mediated Pathogenicity, Ashlyn E. Anderson
Elucidating The Role Of Stat4 In Cd4 T Cell Mediated Pathogenicity, Ashlyn E. Anderson
All ETDs from UAB
While the exact cause of many autoimmune diseases is currently unknown, many genetic factors are associated with increased disease susceptibility such as single nucleotide polymorphisms in the STAT4 gene locus. Signal Transducer and Activator of Transcription 4 (STAT4) is critical for the development and function of Th1 cells; however, many Th1 associated molecules are dispensable for CD4 mediated inflammation such as IFNγ, T-bet, and IL-12Rβ2, suggesting that STAT4 may function outside of the Th1 cell lineage. Importantly, Stat4 has recently been correlated with an inflammatory Th17 cell phenotype. Using a murine model of neuroinflammation, we illustrate that Th17 intrinsic STAT4 …
Behavioral, Environmental, Social, Psychosocial, And Physiological Factors That Impact The Relationship Between Chronic Lung Disease Status And Susceptibility To Electronic Cigarette Use Or Actual Electronic Cigarette Use, Mohammed M. Alqahtani
All ETDs from UAB
There is surge increase in e-cigarettes among adult vulnerable population such as individuals with chronic lung disease (CLD). Currently, there is a lack of understanding of the factors that may lead to the increase use of e-cigarettes or susceptibility of ecigarette use among individuals who have a history of CLD. Thus, it is crucial to recognize the characteristics of the individuals with CLD and adults without CLD who are susceptible to using e-cigarettes because this may pave the way for the prevention and reduction of tobacco use by identifying the different factors and eventually targeting the related risk factors. In …
Factors Influencing Balance And Muscle Tone In Adults With Attention-Deficit/Hyperactivity Disorder, Mansour M. Alotaibi
Factors Influencing Balance And Muscle Tone In Adults With Attention-Deficit/Hyperactivity Disorder, Mansour M. Alotaibi
All ETDs from UAB
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental condition prevalent in children globally and continues to persist into adulthood. Executive function (EF) impairments are core ADHD deficits, specifically response inhibition, and believed to drive ADHD symptoms. Psychostimulant medications (PS) is the first line treatment to manage ADHD symptoms. Overall, individuals with ADHD are at greater risk of falls and physical injuries compared to healthy individuals. Perhaps adults with ADHD balance impairments are secondary to ankle plantarflexor (PF) spasticity. Using psychostimulant medications (PS) improves PF spasticity and postural control in children with ADHD, but the effects on adults with ADHD are unclear. Furthermore, …
Role Of Dietary Compounds On Modulation Of Epigenetic Mechanisms And Gut Microbiota In Prevention Of Breast Cancer, Manvi Sharma
Role Of Dietary Compounds On Modulation Of Epigenetic Mechanisms And Gut Microbiota In Prevention Of Breast Cancer, Manvi Sharma
All ETDs from UAB
Breast cancer is the second leading causes of mortality among women living in the United States, representing a major public health issue. The current chemoprevention therapies can result into various adverse effects. Therefore, the use of dietary bioactive compounds has been of great interest due to their safer, non-toxic and efficacious properties. Sulforaphane (SFN) is an isothiocyanate found in various cruciferous vegetables such as broccoli sprouts (BSp) and green-tea polyphenols (GTPs) contain a major polyphenol, (-)-epigallocatechin-3-gallate (EGCG). These compounds have been shown to exhibit several anticancer properties especially as an epigenetic modifier. We investigated the efficacy of BSp or GTPs …
Bacterial Community Structures And Species Delimitation Of Five-Armed Luidia In The Northern Gulf Of Mexico, Michelle D. Shilling
Bacterial Community Structures And Species Delimitation Of Five-Armed Luidia In The Northern Gulf Of Mexico, Michelle D. Shilling
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Luidia spp. (Family Luidiidae) are important predators in the benthic food web and are abundant in near-shore, shallow soft-bottom habitats throughout the northern Gulf of Mexico. Climate change-related environmental changes, such as ocean warming and acidification, are rapidly intensifying in this region and can have consequences for species diversity as well as individual sea star health through modification of host-associated bacterial communities. Our knowledge of sea star-associated bacterial community structure and dynamics is limited and conflicting genetic evidence has called into question the accuracy of species delimitation of five-armed Luidia in the northern GOM. The primary purpose of this dissertation …
Molecular Mechanism And Impact Of Sox2 Regulation By The Transforming Growth Factor-Ss Members In Ovarian Cancer Survival And Metastasis, Zainab Shonibare
Molecular Mechanism And Impact Of Sox2 Regulation By The Transforming Growth Factor-Ss Members In Ovarian Cancer Survival And Metastasis, Zainab Shonibare
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Ovarian cancer is the second most common and deadliest cancer of the female reproductive system affecting women in the United States and worldwide. The poor survival outcome seen in ovarian cancer is attributed to the subtleness of its early-stage symptoms, resulting in a majority of patients at initial diagnosis presenting with an advanced-stage disease with metastasis to other parts of the body. Hence, there is an urgent need to better understand the molecular etiology of metastasis to help develop effective therapeutic options and improve clinical outcomes in ovarian cancer patients. Ovarian cancer, an intra-abdominal cancer, most preferably undergoes metastasis via …
Filtration And Adsorption Performance Of Activated Carbon Fiber: Applications For Respiratory Protection, Margaret C. Summers
Filtration And Adsorption Performance Of Activated Carbon Fiber: Applications For Respiratory Protection, Margaret C. Summers
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Activated Carbon Fiber (ACF) is an adsorbent material that can be used to re-move volatile organic compounds (VOCs) from the air. Unlike granular adsorbents that are currently used in organic vapor respirators, ACF is a self-supporting fiber structure that can be tailored into non-woven forms and can potentially be used to support particu-late filtration. While ACF-containing respirators first appear in patent literature in the 1980s, the use of ACF in respiratory protection has not been widely considered in the PPE market in the intervening years. To develop the concept of an ACF-containing N95 that offers particulate filtration in addition to …
Promoting The Safe Mobility Of Young Adults With Autism Spectrum Disorder, Austin M. Svancara
Promoting The Safe Mobility Of Young Adults With Autism Spectrum Disorder, Austin M. Svancara
All ETDs from UAB
Having access to adequate transportation is important for employment, healthcare, and community involvement needs. Unfortunately, the transportation needs of many individuals with autism spectrum disorder (ASD) are currently not being met. Despite having the capability to achieve licensure, a significant portion of high functioning individuals with ASD are delaying licensure or not getting their driver’s license at all. High functioning individuals with ASD are likely to have the capacity to operate a motor vehicle safely, supporting the proposition that there are existing barriers to licensure beyond the contributing role of ASD traits. This dissertation examined the perceived driving styles and …