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Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt Jan 2008

Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt

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Asthma is identified by the clinical symptoms of wheezing, chest tightness, dyspnea and cough, and by the presence of airway hyperresponsiveness (AHR) to inhaled stimuli. We have reported previously that repeated bouts of moderate intensity aerobic exercise attenuate airway inflammatory responses in a mouse model of atopic asthma. Because the effects of exercise on physiological responses are dependent upon several variables, including total exercise duration, the hypothesis of the current work was that differing amounts of moderate intensity aerobic exercise exert dissimilar effects on AHR and airway inflammation. The aims to test this hypothesis included: 1) determine the effect of …

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Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He Jan 2008

Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He

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B lineage cells are major players in the adaptive immune system. Pax5 is essential for B lineage cell development and function. Pax5 controls B lineage cell developmental progression by regulating expression of many B lineage specific genes and the B lineage specific VH to DJH recombination; and the meantime, Pax5 also represses the transcription of lineage- and developmental stage- inappropriate genes to restrict the B lineage developmental pathway. It is not clear how Pax5-mediated function can be regulated to fulfill its role in different biological reactions. In this dissertation, we focused on the study of the molecular regulation of Pax5-mediated …

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Biogenesis, Trafficing, And Function Of Wild-Type And Mutant Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), Asta Jurkuvenaite Jan 2008

Biogenesis, Trafficing, And Function Of Wild-Type And Mutant Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), Asta Jurkuvenaite

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Cystic fibrosis (CF) is a genetic disease resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel that functions at the apical surface of epithelial cells and plays a critical role in mucociliary clearance. The most common mutation in the CFTR gene involves a deletion of phenylalanine at position 508 in the protein (ΔF508 CFTR). ΔF508 CFTR is recognized as misfolded in the endoplasmic reticulum (ER) and is degraded. In vitro manipulations such as culturing cells at 27°C can “rescue” ΔF508 CFTR to the plasma membrane (rΔF508 CFTR), but no pharmacological agent has produced comparable …

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Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka Jan 2008

Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka

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Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique capable of in vivo characterization of the spatial and angular dependence of free water diffusion in tissue. By studying intra- and extra-cellular water mobility, inference can be made about the surrounding medium. The non-uniform angular dependence of diffusion, known as anisotropy, is evident in fibrous tissues, which exhibit greater diffusion parallel versus perpendicular to the fiber orientation. DTI’s sensitivity to anisotropy makes it an effective tool for measuring the integrity of fibrous myelinated white matter tracts in the brain. For demyelinating diseases such as multiple sclerosis (MS), DTI has …

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The Role Of Ddx3 In Regulating Apoptosis, P53 And Snail, Mianen Sun Jan 2008

The Role Of Ddx3 In Regulating Apoptosis, P53 And Snail, Mianen Sun

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Cancer is a common disease that causes high rates of lethality. Resistance to cancer therapy is one major obstacle for producing an effective cancer treatment. Clarifying mechanisms of cancer development, such as resistance to apoptosis and metastasis, can provide important information for developing effective cancer treatment strategies. In the present study, DDX3 was demonstrated to have effects on both responses to cancer treatment and cancer development. DDX3 together with glycogen synthase kinase-3 (GSK-3) was found to impede death receptor-induced apoptosis, which is important because death receptors are activated by some cancer treatments. Additionally, DDX3 was shown to regulate two proteins …

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Mapks Regulate Nuclear Import Of Human Papillomavirus Type 11 Replicative Helicase E1, Jei-Hwa Yu Jan 2008

Mapks Regulate Nuclear Import Of Human Papillomavirus Type 11 Replicative Helicase E1, Jei-Hwa Yu

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Papillomaviruses (PV) are prevalent pathogens that infect human or animal squamous epithelia. Its genome is a double strand circular DNA of approximately 7.9 kb. It contains origin of replication (ori) and encodes early viral proteins for viral DNA amplication, and late capsid proteins for packaging viron. The viral DNA replicates as extrachromosomal nuclear plasmid in the host cell. Infections by low risk virus, such as HPV-6 and -11, can result in benign papillomas, condylomata, and low grade squamous intraepithelial dysplasias (SIL), whereas infection by high risk virus, such as HPV-16 and -18, can progress to high grade SIL, carcinoma in …

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Potential Iatrogenic Effects On Enamel Treated With A Light Cured Flouride Releasing Filled Resin, Henry G. Griggs Jan 2008

Potential Iatrogenic Effects On Enamel Treated With A Light Cured Flouride Releasing Filled Resin, Henry G. Griggs

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White spot lesions have long been a problem in fixed appliance orthodontic treatment. Various methods of prevention have been used in the past, most requiring patient compliance. The use of non-compliant orthodontic sealants to form a barrier on the facial surface of the tooth has been attempted in the past with limited success due mainly to the inability of composite resins to fully polymerize. Pro Seal(Reliance Orthodontic Products, Inc, Itasca, IL) is new product which claims to fully polymerize and provide protection from white spot lesions during orthodontic treatment. In vitro studies support this claim. The side effects of acid …

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The Use Of Modeling Tools In The Analysis Of Functional Requirements, Gopi Kamadia Jan 2008

The Use Of Modeling Tools In The Analysis Of Functional Requirements, Gopi Kamadia

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The thesis offers an Object-Oriented analysis methodology to investigate the functional requirements of software systems with modeling technologies, such as Unified Modeling Language (UML) and Systems Modeling Language (SysML). The main focus of the analysis is to discover objects and describe them in the problem domain. The thesis also proposes a validation process for the requirements stage of the development life cycle with an Acclaro Design For Six Sigma (DFSS) approach. A software development experiment is carried out with a case study of a threedimensional graphics game. The game is first implemented without following any sound analysis process and then …

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Electrospun Tri-Layer Micro/Nano-Fibrous Scaffold For Vascular Tissue Engineering, Xing Zhang Jan 2008

Electrospun Tri-Layer Micro/Nano-Fibrous Scaffold For Vascular Tissue Engineering, Xing Zhang

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No abstract provided.

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Awareness Of Functional Difficulties In Mild Cognitive Impairment: Relation To Cognitive Variables And Mood, Ozioma C. Okonkwo Jan 2008

Awareness Of Functional Difficulties In Mild Cognitive Impairment: Relation To Cognitive Variables And Mood, Ozioma C. Okonkwo

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No abstract provided.

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Indicators Of Self-Rated Driving Ability Among A Community-Based Sample Of Older Adults, Michelle Lynn Ackerman Jan 2008

Indicators Of Self-Rated Driving Ability Among A Community-Based Sample Of Older Adults, Michelle Lynn Ackerman

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No abstract provided.

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The Adaptive Immune System Of Sea Lamprey, Matthew N. Alder Jan 2008

The Adaptive Immune System Of Sea Lamprey, Matthew N. Alder

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No abstract provided.

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Factors Influencing The Use Of Outcome Measures In Physical Therapy Practice, Frances M. Wedge Jan 2008

Factors Influencing The Use Of Outcome Measures In Physical Therapy Practice, Frances M. Wedge

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No abstract provided.

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Microarray Data Analysis For Snp Effects And Inferring Alternative Splicing, Lang Chen Jan 2008

Microarray Data Analysis For Snp Effects And Inferring Alternative Splicing, Lang Chen

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No abstract provided.

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Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai Jan 2008

Effects Of Hexosamine Biosynthesis On An In Vitro Model Of Cardiacischemia, Voraratt Champattanachai

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Increased levels of protein O-linked-N-acetylglucosamine (O-GlcNAc) have been correlated with increased cell survival following stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, improved the tolerance of isolated neonatal rat ventricular myocytes (NRVMs) to ischemia/reperfusion (I/R) injury. NRVMs were exposed to hypoxic medium for 4 hours, followed by oxygenated complete medium for 16 hours. Acute treatment with 5 mM glucosamine showed an increase in viability and decreased both necrosis and apoptosis following I/R. Glucosamine increased O-GlcNAc levels maximally at 2 hours and went …

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The Relationship Of Medical Homeness To The Quality Of Life Of Mothers Of Children With And Without Special Health Care Needs, Cynthia G. Cortes Jan 2008

The Relationship Of Medical Homeness To The Quality Of Life Of Mothers Of Children With And Without Special Health Care Needs, Cynthia G. Cortes

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A cross-sectional study was conducted to investigate the relationship of child, family, and medical home status to quality of life for mothers of children with and without special health care needs. Mothers of children with (n=100) and without (n=80) special health care needs, completed a questionnaire at a children’s hospital in the southeastern United States focusing on the child, family, and medical home and maternal quality of life. Standardized instruments were used to measure quality of life (SF-36) and social support (Social Support Questionnaire). Non-standardized instruments used in other research were incorporated into the maternal questionnaire. Logistic and linear regression …

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Structural And Functional Properties Of Human Αa-Crystallin, Jose Mauro Chaves Jan 2008

Structural And Functional Properties Of Human Αa-Crystallin, Jose Mauro Chaves

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The three specific aims of the project were: (1) compare effects of deamidation alone (i.e., αA-N101D, αA-N123D, αA-N101/123D), truncation alone (αA-NT mutant [deletion of residue no. 1-63], or αA-CT mutant [deletion of residue no. 140-173]), or both truncation plus deamidation on structural and functional properties of human lens αA-crystallin; (2) identify components of complexes in the water soluble-high molecular weight (WS-HMW) proteins of normal aging and cataractous human lenses; and (3) determine interactions among WT-αA, αA-NT and αA-CT crystallin species with filensin and phakinin (beaded filament proteins) in vitro. The comparative structural and functional differences between αA-deamidated and/or truncated mutants …

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Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace Jan 2008

Microbial Biofilm Attachment To Caenorhabditis Elegans, Kevin Drace

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The closely related bacterial species Xenorhabdus nematophila, Yersinia pestis and Y. pseudotuberculosis make biofilms capable of adhering to the head of the model nematode Caenorhabditis elegans. Y. pestis uses biofilms to block the digestive tract of its vector, the flea, in order to enhance its efficiency of transmission. I investigated the role of biofilms in X. nematophila and found that, like its Yersinia sp. counterparts, production of biofilm requires a four-gene operon: hmsHFRS. X. nematophila is an insect pathogen and an obligate symbiont of the nematode Steinernema carpocapsae. However, an X. nematophila hmsH mutant that failed to make biofilms on …

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Phenomenological Study: What Are Pre-Kindergarten Teachers' Lived Experiences With Children Identified With Conduct Disorder, Oppositional Defiance Disorder, And Attention-Deficit Hyperactivity Disorder In The Southeastern United States?, Danna Benefield Jones Jan 2008

Phenomenological Study: What Are Pre-Kindergarten Teachers' Lived Experiences With Children Identified With Conduct Disorder, Oppositional Defiance Disorder, And Attention-Deficit Hyperactivity Disorder In The Southeastern United States?, Danna Benefield Jones

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To date, a vast amount of research has been conducted on disruptive behavior dis-orders such as conduct disorder (CD), oppositional defiance disorder (ODD), and atten-tion deficit hyperactivity disorder (ADHD. However, a paucity of research exists in spe-cific areas such as how teachers’ handle students diagnosed with these disorders. The cur-rent situation in pre-kindergarten may undermine the ability of these students to succeed in the school system. This is seen in the fact that a large number of these students are removed from pre-kindergarten programs across the United States (Webster-Stratton, Reid, & Hammond, 2004). Understanding pre-kindergarten teachers’ lived experiences in handling …

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Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak Jan 2008

Role Of The Gm/Gn Glycoprotein Complex In The Final Assembly And Egress Of The Human Cytomegalovirus (Hcmv), Magdalena Anna Krzyzaniak

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HCMV consists of a dsDNA genome enclosed by, an icosahedral capsid surrounded by a layer of tegument proteins; the virion structure is enclosed in a lipid envelope rich in virus expressed glycoproteins. The HCMV envelope contains an incompletely defined number of glycoproteins. The glycoprotein M (gM) and glycoprotein N (gN) form a gM/gN protein complex which is the most abundant protein component of the HCMV envelope. Recent studies have indicated that deletion of the viral gene encoding either gM or gN is lethal for HCMV. The gM C-terminal cytoplasmic tail (gM-CT) revealed an acidic cluster and a tyrosine-based trafficking motifs. …

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Punctal Occlusion Impact On Tear Film Immuno-Regulatory Proteins Measured By Cytometric Bead-Based Assay, Martin W. Lafrance Jan 2008

Punctal Occlusion Impact On Tear Film Immuno-Regulatory Proteins Measured By Cytometric Bead-Based Assay, Martin W. Lafrance

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PURPOSE: This study compares vendor reagents used for cytometric bead-based assay (CBA) of cytokines in human tears and validates a protocol for use in evaluating punctal occlusion, a treatment for keratoconjunctivitis sicca. It has been proposed that punctal occlusion may alter tear cytokine concentrations based on the facts that: (1) tear clearance, a measure of the balance between tear production and elimination, declines following occlusion and (2) reduced tear clearance and increased levels of pro-inflammatory tear cytokines are correlated in dry eye patients. This study compares tear clearance values and the level of 24 tear cytokines measured by CBA following …

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Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee Jan 2008

Transcriptional Regulation Of Cd40 And Class Ii Mhc Molecules In Macrophages And Microglia By Statins, Sun Jung Lee

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Microglia/macrophages are the main intrinsic immune effector cells and the first cell types that respond to a variety of CNS injures. They have important functions including secretion of cytokines/chemokines and antigen presentation, thereby regulating immune responses. Interferon-γ (IFN-γ) is a cytokine involved in many aspects of the immune response, and activates microglia/macrophages to express cell surface antigens such as class II MHC, and co-stimulatory molecules such as CD40. CD40 and class II MHC molecules play a critical role in immune reactivity such as antigen presentation and subsequent T cell activation. However, aberrant CD40 and class II MHC expression have been …

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The Induction Of First Year And Transferring Elementary School Teachers: A Multiple Case Study, Patricia L. Lequier Jan 2008

The Induction Of First Year And Transferring Elementary School Teachers: A Multiple Case Study, Patricia L. Lequier

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This qualitative, multiple case study explored the experiences of elementary teachers and principals participating in school induction processes. The staggering rates at which new teachers are leaving the profession, coupled with high rates of teacher attrition, teacher retirements, and increases in student enrollment formed the impetus for this study. These factors have collectively contributed to the nation’s crucial demand for close to two million teachers. In an effort to increase the retention rate of new teachers, schools across the nation have implemented teacher induction processes. Teacher induction processes focus on providing support for teachers in their transition from their roles …

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Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li Jan 2008

Interim Monitoring Efficacy, Safety And Futility In Phase Iii Clinical Trials, Qing Li

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Phase III trials often have both efficacy and safety outcomes. Sometimes the safety outcomes are closely associated with the efficacy outcomes. We sought to find a statistical method to treat both efficacy and safety outcomes as bivariate primary outcomes and set up stopping rules at interim stages based on the following criteria: (1) greater safety; (2) greater efficacy; (3) futility. We first examined the internal pilot design to adjust sample size for clinical trials with a bivariate response (efficacy and safety). Three nuisance parameters (two variances and correlation) need to be considered when doing sample size recalculation for the internal …

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The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra Jan 2008

The Au-Rich Element Mrna Decay-Promoting Activity Of Brf1 Is Regulated By Mitogen-Activated Protein Kinase Activated Protein Kinase 2, Sushmit Maitra

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Regulated mRNA decay is a highly important process for the tight control of gene expression. Inherently unstable mRNAs contain AU-rich elements (AREs) in the 3’ untranslated regions that direct rapid mRNA decay by interaction with decay-promoting ARE-binding proteins (ARE-BPs). The decay of ARE-containing mRNAs is regulated by signaling pathways, which are believed to directly target ARE-BPs. Here, we show that BRF1 involved in ARE-mediated mRNA decay (AMD) is phosphorylated by MAPK-activated protein kinase 2, MK2. In vitro kinase assays using different BRF1 fragments suggest that MK2 phosphorylates BRF1 at four distinct sites, S54, S92, S203, and an unidentified site at …

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The Physical And Mental Health Of Spouse Caregivers In Dementia: Finding Meaning As A Mediator Of Burden, Susan M. Mclennon Jan 2008

The Physical And Mental Health Of Spouse Caregivers In Dementia: Finding Meaning As A Mediator Of Burden, Susan M. Mclennon

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The purpose of this study was to examine the effect of caregiver burden on the physical and mental health of caregivers of spouses with dementia and to determine if finding meaning through caregiving mediated the relationship between burden and health. This was a cross-sectional, correlational study in a convenience sample of 84 community-residing spouse caregivers of adults with dementia recruited from North- Central Florida. Measures included the Zarit Burden Interview, the Finding Meaning through Caregiving Scale, and the Medical Outcomes Short Form-36, version 2. Data analyses consisted of descriptive, correlational, and standard multiple regression statistical methods. The sample consisted of …

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Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore Jan 2008

Modulation Of Transforming Growth Factor (Tgf)-Ss1 And Its Implications In Breast Cancer Metastasis, Lakisha Dionne Moore

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Overexpresssion of transforming growth factor (TGF)-β has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers including carcinoma of the breast. Thus, targeted downregulation of TGF-β1 expression in breast cancer in situ and determination of its implications potentially could provide new treatment approaches for disease management. siRNA constructs targeting TGF-β1 were validated and used to develop clonal derivatives of the MDA-MB-435 metastatic breast cancer cell line. Inhibition of TGF-β1 expression in MDA-MB-435 cells showed decrease in migration and invasion in vitro with an increase in proliferation. In vivo analysis indicated a 90% decrease …

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The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore Jan 2008

The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore

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In the nervous system, PI 3-kinase has been implicated in neuronal differentiation. My studies have focused on a candidate neuronal PI 3-kinase target centaurin alpha-1, which binds PtdIns(3,4,5)P3, and is an Arf6 GAP. Centaurin alpha-1 is localized in dendrites, dendritic spines and synapses, and is required for neuronal differentiation and spine morphogenesis. In dissociated neuronal cultures, expression of centaurin alpha-1 enhances dendritic branching, and increases dendritic filopodia, lamellipodia and spine-like protrusions. Expression of centaurin alpha-1 GAP inactive mutant or knocking down centaurin alpha-1 levels using siRNA leads to inhibition of dendritic outgrowth and branching. Manipulations of centaurin alpha-1 also disrupt …

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Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols Jan 2008

Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols

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Overweight and obesity in school-aged children have become a major health issue. With overweight and obesity, children have increased risk of developing elevated blood pressure readings, glucose levels, and cortisol. Trait anger and patterns of anger expression have been shown to contribute to the elevations of blood pressure, glucose and cortisol in normoweight children and overweight adolescents. However, little research has been done with overweight school-aged children. The purpose of this study was to examine the relationships among trait anger and each of the patterns of anger expression (anger-suppression, anger-out, and anger-reflection/control) and blood pressure, glucose, and cortisol in overweight …

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Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo Jan 2008

Investigation Of Lipoteichoic Acid Structure And Function To Establish Its Role In Gram-Positive Bacterial Infections, Ho Seong Seo

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Lipoteichoic acid (LTA) is an essential bacterial membrane polysaccharide (cell wall component) that is linked to a glycerol backbone with two acyl chains. Since an antibody to LTA has been shown to protect from Gr+ bacterial infections or colonization, and the mutant Gr+ bacteria which produce less amount of LTA have less pathogenic than WT, LTA may be an important role in Gr+ bacterial infection and inflammation. The currently accepted structure of pneumococcal LTA has the pentameric repeating unit bound to the lipid anchor {Glc(β1��3)AATGal(β1��3)Glc(α1��3)-acyl2Gro}. Unlike the lipid anchor of other Gr+ bacterial LTA, this pneumococcal LTA lipid anchor has …

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