Digital Commons Network^™

Safety And Synergy Of Finerenone And Empagliflozin In Lowering Blood Pressure, Rajiv Agarwal, Ricardo Correa-Rotter, Sankar D Navaneethan, Hiddo J L Heerspink, Matthew R Weir, Janet B Mcgill, Amy K Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Charlie Scott, Li Li, Meike Brinker, Csaba P Kovesdy, Jennifer B Green, Johannes F E Mann

Faculty, Staff and Students Publications

Background: This secondary analysis of the CONFIDENCE (combination effect of fInerenone and empagliflozin in participants with chronic kidney disease and type 2 diabetes using a UACR endpoint) trial (REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05254002) assessed systolic blood pressure (SBP) changes with empagliflozin/finerenone combination therapy versus monotherapy in people with chronic kidney disease and type 2 diabetes across baseline SBP categories. We assessed SBP response predictors and whether early (day 30) SBP changes mediate urinary albumin-to-creatinine ratio reductions.

Methods: Participants (n=800) were stratified by baseline SBP (< 130 mm Hg; ≥130 mm Hg). Outcomes included SBP response (≥10 mm Hg reduction from baseline at day 180) and longitudinal SBP changes, analyzed by linear mixed-effects models and logistic regression. Causal mediation analysis, a secondary exploratory analysis, evaluated the effect of day 30 SBP change on day 180 urinary albumin-to-creatinine ratio reduction.

Results: At baseline, 532 (66%) participants had SBP ≥130 mm Hg; 268 (34%) …

Histone Deacetylase Enzyme Activity Is Not The Universal Anticancer Target Of Hdac Inhibitors, Chaitra Rai, Hang Ruan, Xue Li, Wenbo Li, Hyun-Hwan Jeong, Chengchuang Song, Panpan Liu, Yingjie Chang, Hao Fang, Udhaya Kumar S, Yuxiang Sun, M James You, Dongyin Guan, Zhandong Liu, Leng Han, Xuben Hou, Zheng Sun

Faculty, Staff and Students Publications

Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, our unbiased bioinformatics analyses found that, for most cancer types, expression levels or genetic variants of histone deacetylase (HDACs) do not consistently correlate with carcinogenesis, do not predict cancer patient survival, and do not associate with cellular responses to HDIs. Whole-genome CRISPR library screens did not identify HDACs as genes affecting cellular responses to HDIs. Overexpression of dominant-negative Class I HDACs causes similar protein hyperacetylation …

Growth In Early Infancy Drives Optimal Brain Functional Connectivity Which Predicts Cognitive Flexibility In Later Childhood, Chiara Bulgarelli, Anna Blasi, Samantha Mccann, Bosiljka Milosavljevic, Giulia Ghillia, Ebrima Mbye, Ebou Touray, Tijan Fadera, Lena Acolatse, Sophie E Moore, Sarah Lloyd-Fox, Clare E Elwell, Adam T Eggebrecht, Bright Study Team

2020-Current year OA Pubs

Functional brain network organisation, measured by functional connectivity (FC), reflects key neurodevelopmental processes for healthy development. Early exposure to adversity, for example undernutrition, affects neurodevelopment, observable via disrupted FC, and leads to poorer outcomes from preschool age onwards. We assessed longitudinally the impact of early growth trajectories on developmental FC in a rural Gambian population from age 5-24 months. To investigate how these early trajectories relate to later childhood outcomes, we assessed cognitive flexibility at 3-5 years. We observed that early physical growth before the fifth month of life drove optimal developmental trajectories of FC that in turn predicted cognitive …

Entre La Lucha: Familismo And Well-Being Of Latino Immigrant Families Navigating Manual Labor And Anti-Immigrant Sentiment, Faviola Robles Saenz

Dissertations and Theses

The United States' history of treatment toward Latino immigrants has been shaped by anti-immigrant sentiment and exploitative labor practices, creating psychological violence that harms their families' well-being. Although previous research has examined anti-immigrant sentiment, labor conditions, and familismo among Latinos, these areas are often studied in isolation, with limited attention to their intersections and how they are experienced across generations. Informed by history, prior research, and my lived experiences, this study qualitatively explored the intersections of anti-immigrant sentiment and parents' manual labor to understand how these contexts shape familismo and well-being among Latino immigrant families. This work was grounded in …

Relationship Between Sleep And Meal Timing With Glycemia Parameters In Individuals With Obesity Participating In A Randomized Time-Restricted Eating Study., Sirimon Reutrakul, Stacey L. Simon, Qi Wang, Emily N C Manoogian, Satchindananda Panda, Suryeon Ryu, Zan Gao, Caleb Griffiths, Erika Helgeson, Douglas G. Mashek, Niki Oldenburg, Lisa Senye Chow

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Circadian misalignment, including mistimed sleep or eating, is associated with altered glucose metabolism. The importance of eating window timing for time-restricted eating (TRE) is increasingly recognized. This secondary analysis examined associations between meal to sleep timing intervals and glycemic parameters in individuals with obesity across three dietary interventions [TRE, CR: caloric restriction, and UE: unrestricted eating]. Methods: Participants aged 18-65 years with obesity were randomized to a 12-week intervention: TRE (8 h eating window), CR (15% reduction in daily caloric intake), or UE (usual eating habits). CGM and actigraphy were assessed over two weeks at baseline and end-intervention. Mixed …

Imaging And Non-Imaging Approaches For The Diagnosis And Monitoring Of Necrotizing Enterocolitis-What Lies Ahead?, Indrani Bhattacharjee, Catalina Le Cacheux, Eric B. Ortigoza, Jonathan Dillman, Sherwin S. Chan, Alain Cuna

Manuscripts, Articles, Book Chapters and Other Papers

Necrotizing enterocolitis (NEC) remains one of the most serious gastrointestinal emergencies in preterm infants, and imaging plays a central role in diagnosis and clinical management. Historically, evaluation has relied primarily on abdominal radiography, which remains widely available and embedded in established diagnostic frameworks. However, the hallmark radiographic signs of NEC (i.e., pneumatosis intestinalis, portal venous gas, and free air) reflect relatively advanced manifestations of intestinal injury that indicate established mucosal disruption or transmural necrosis. Bowel ultrasound has increasingly complemented radiography by enabling real-time assessment of bowel wall integrity, perfusion, motility, and intra-abdominal fluid, providing physiologic information that may refine clinical …

Scaffolded Reflection And Research Assignment For Sociology 101, Sara Martucci

Open Educational Resources

Dr. Sara Martucci created these assignments as part of a funded project focused on converting more sections of high-enrollment foundational courses to use Open Educational Resources and Pedagogy.

Stress-Activated Pathways Mediate Pfas Effects On Human Placental Syncytiotrophoblast Cells., Keisuke Kozai, Kaela Varberg

Manuscripts, Articles, Book Chapters and Other Papers

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants associated with placenta-mediated pregnancy complications, including preeclampsia, fetal growth restriction, and preterm birth. The syncytiotrophoblast (STB), which forms the placental barrier at the maternal-fetal interface and is directly exposed to maternal blood, is a primary site of PFAS exposure. Although PFAS induce STB apoptosis, the upstream stress-signaling pathways involved remain poorly defined. Here, we investigated stress-responsive signaling mechanisms mediating PFAS-induced STB cell death. STB differentiated from human trophoblast stem cells were exposed to vehicle or an environmentally relevant mixture of 5 PFAS (perfluorooctanoic acid, perfluorooctanesulfonic acid, perfluorohexane sulfonate, perfluorononanoic acid, and …

Automated Physical Activity Support For Adults And Youth From Low-Income Communities: Single-Arm Pilot Study., Jordan A. Carlson, Frank T. Materia, Mallory Moon, Suryeon Ryu, Cory Yeager, Chelsea Steel, Kacee Shields, Harpreet Singh Gill, Jannette Berkley-Patton, Delwyn Catley

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Mobile health (mHealth) interventions are growing in popularity, but less research has focused on low-income families, particularly interventions integrating wearable devices with automated personalized messages.

OBJECTIVE: We tested a preliminary wearable-integrated mHealth intervention with initial personalization elements among adults and youth from low-income urban communities, focusing on feasibility, acceptability, and preliminary evidence of physical activity behavior.

METHODS: Participants were 83 adults and 31 youth recruited through community health events held in low-income urban communities. Using a single-arm pre-post design, participants were enrolled into a 7-week beta-version mHealth intervention that integrated a Garmin activity monitor with automated text messages. Messages …

Evaluating Chest-Worn Light Logger Adherence: Development And Application Of A Wear/Non-Wear Model, Carlyn Patterson Gentile, Adah Thomas, Ryan Shah, Blanca Marquez De Prado, Nichelle Raj, Christina Szperka, Geoffrey Aguirre

Student Papers, Posters & Projects

Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to (1) develop methodology for differentiating adherent versus non-adherent use, and (2) define differences in lighting intensity in indoor and outdoor environments, to improve data reliability in future clinical studies using this technology. Four testers used a 10-channel chest worn light logging device under different conditions of wear and non-wear (experiment 1), and another tester made measurements with the light logger across a variety of …

‘Wala Kaming Alam Sa Stroke Care’ (We Don’T Know Anything About Stroke Care): Experiences Of Care Providers Delivering Stroke Rehabilitation Care In The Philippines, Fiona Leggat, Sarah Ann Buckingham, Aira Patrice Rueda Ong, Bridie Kent, Nena Marie Santos, Annah Teves, Vergil Boac, Paula Melizza Valera, Elda Anota, Maria Mercedes Barba, Myrna Estrada, Neil Bryan Pita, Alyssa Dar Juan, Lorraine Faeldon, Fiona Jones

School of Nursing and Midwifery

BackgroundIn the Philippines, rising stroke prevalence and healthcare inequalities present a concerning outlook. While acute stroke care is prioritised, rehabilitation remains undervalued. The experiences of healthcare providers who deliver stroke support are also under-researched.Objective(s)Our study aimed to explore the experiences and needs of care providers across multiple regions of the Philippines to inform the development of stroke support initiatives and programmes.MethodsForming part of the Tulong, Ugnayan ng Lingap At gabaY (TULAY) project, a qualitative descriptive design involving semi-structured interviews was used. Care providers with professional or voluntary community healthcare service delivery roles were recruited. Data were analysed using reflexive thematic …

Panel Discussion: Recognizing Research Data In Tenure & Promotion: Turning Policy Principles Into Practice, John Chodacki, Kristi Holmes, Sean Mooney, Su Nee Goh

FORCE 2026

Despite growing attention to open science and data sharing, most institutional reporting processes as well as assessment guidelines (e.g. for tenure and promotion) still fail to recognize research data as a first-class scholarly output. This gap hinders progress in open data practices and efforts to make research outputs more open, reusable, and reproducible.

This session builds on the work of the Implementing Data Evaluation in Academia initiative, which has developed a maturity model for data evaluation at institutions, template policy language for data recognition, and case studies from early-adopter universities. The panel will bring perspectives from institutions at varying stages …

Asian Open Research Data And Its Potential For Ai: Bridging The Digital Divide Through Strategic Data Sharing, Mark Hahnel, Simon Porter

FORCE 2026

The growing momentum for open research data in Asia intersects with global advances in artificial intelligence (AI). Open data policies and infrastructures are increasingly recognized as critical enablers of research equity, reproducibility, and innovation. This talk examines the current state of open academic data, highlights economic and scientific arguments for its adoption, and explores the transformative potential of Asian open data ecosystems in powering AI-driven discovery. Drawing on global examples such as the Protein Data Bank and emerging health datasets, the discussion positions Asian institutions to leverage open strategies that simultaneously meet compliance mandates, enhance visibility, and accelerate breakthroughs in …

Controversy Associated With Red-Light Traffic Cameras, Alan D. Smith, Anna Abdulmanova

Atlantic Marketing Association Proceedings

No abstract provided.

Assessment Beyond Transactions: Measuring Library Impact In Knowledge Synthesis And Research Support, Shameem Nilofar Maideen

FORCE 2026

As newer forms of research assessment emerge that move away from narrow bibliometric indicators toward holistic evaluation of scholarly contributions, academic libraries face both an opportunity and a challenge to articulate their value beyond transactional metrics. Traditional library assessments such as circulation statistics, database logins, and reference transactions fail to capture libraries' increasingly sophisticated roles in knowledge synthesis, research integrity support, and fostering interdisciplinary collaboration.

This session explores emerging and possible assessment methodologies that align library evaluation with broader research assessment reform movements. Through examples from Singapore Management University Libraries' transformation toward knowledge partnership models and an analysis of innovative …

Diamond Open Access Journals In India: Status, Sustainability And Challenges, Mallikarjun Dora, Kanagasabai K, Raj Kishor Kampa

FORCE 2026

Open-access publishing has transformed scholarly communication in recent decades. The share of OA articles between 2014 and 2024 increased by 26%, from a modest 14% in 2014 to 40% in 2024. OA journals have evolved over time and exist in various models based on funding mechanisms, including the Gold, Green, Hybrid, and Diamond models. While OA publishing emerged in response to scientific inequality, middle- and low-income countries face the barrier of high Article Processing Charges (APC), which hinder them from publishing in those journals (Alperin, 2022). The Article Processing Charges are part of the Gold and Hybrid OA models, where …

Oxa: An Open Exchange Architecture For Modular And Computational Scientific Content, Nokome Bentley, Rowan Cockett, Tracy Teal

FORCE 2026

Scientific communication remains bound by legacy formats designed for print, even as research itself has become computational, collaborative, and continuous. The Open Exchange Architecture (OXA, https://oxa.dev), is a community-driven schema and specification for representing scientific documents as structured, interoperable JSON. Developed in collaboration/participation with projects such as Jupyter, MyST, Stencila, Curvenote, Posit (Quarto), openRxiv, PLOS, eLife, Octopus, Creative Common, and the Continuous Science Foundation, OXA defines typed, linkable nodes (text, math, code, figures, metadata) that together form a shared “bedrock” for interoperable, modular, machine-readable, and executable research.

OXA allows for the exchange of scientific content across authoring environments (MyST …

Landscapes Of Exclusion: Mapping Racial Boundaries And Environmental Burdens, Monique A. Baxter

2026 Symposium

Inspired by the author’s work with the mapping team for the Eastern Washington University Racial Covenants Project, this project uses additional GIS layers to reveal the enduring imprint of historic racial exclusion on today’s urban landscape. Spokane, Washington’s landscape, like many urban areas across the country, bears the imprint of racial exclusion through mechanisms such as restrictive covenants and redlining. This project examines how racial covenants and red lining layers relate to current brownfield and superfund sites to shape Spokane’s long-term environmental injustice. Using digitized property records, historic zoning maps, and GIS spatial analysis, this project demonstrates that historically red …

[2026 Honorable Mention] Chumash Heritage National Marine Sanctuary, Daylyn R. Reese

Ethnic Studies Research Paper Award

This research offers unique insights into the creation and development of the Chumash Heritage National Marine Sanctuary (N.M.S.) with a focus on indigenous populations’ roles (primarily Chumash and Costanoan). In this episode, I analyze what makes this NMS different from every NMS precluding it, how it recognizes a new goal in conservation (thrivability), and the areas in which improvements still must be made to authentically include and honor indigenous voices.

Archiving In Advance Of Mission Completion, Molly Stothert-Maurer

Journal of Western Archives

This paper presents a detailed case study of the born-digital archiving efforts associated with the National Aeronautics and Space Administration's Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer (OSIRIS-REx) Asteroid Sample Return Mission at the University of Arizona Libraries Special Collections. From the perspective of an archivist, the project exemplifies the integration of digital archiving into an active scientific mission, conducted in collaboration with multiple departments across the university. By preserving mission-critical content, including project management documents, social media interactions, and web content, this initiative serves as a model for resource light digital products utilizing batch descriptive techniques. The paper …

Enhancing Digital Literacy Programmes For Advanced Search Skills Of Adult Public Library Patrons, Santel Smit Ms., Nikiwe G. Momoti Dr

Urban Library Journal

Digital literacy enables individuals to confidently engage with electronic devices and digital resources. While many adults use these tools to search for information, some still lack the essential skills to do so effectively. This pragmatic paper investigates the basic digital literacy skills of adult patrons at Adriaanse Public Library in Cape Town. Framed by SCONUL Seven Pillars of Information Literacy through a Digital Literacy “lens”, we employed a sequential mixed-methods approach, combining quantitative pre- and post-tests with qualitative interviews among 30 purposively selected participants. Quantitative data was analyzed statistically while thematic analysis was used for qualitative data. The findings revealed …

Current Status Of Anthelmintic Resistance In Meat Goats: A Comparative Efficacy Study Of Albendazole And Fenbendazole In Maha Sarakham, Thailand, Minta Pipatsakulpak, Usanisa Boonum, Kotchakorn Roongruang, Benjawan Sae-Chue, Sukanya Leethongdee, Songsak Chumpawadee, Nattaya Watwiengkam, Pongphol Pongthaisong

The Thai Journal of Veterinary Medicine

Anthelmintic resistance in gastrointestinal nematodes threatens sustainable goat production globally. While resistance is well-documented in many regions, data from Thailand remain limited. This study determined the prevalence of gastrointestinal nematodes and assessed the efficacy of albendazole and fenbendazole in meat goats in Maha Sarakham province, northeastern Thailand. A two-stage cross-sectional study was conducted on 10 meat goat farms between August 2021 and March 2022. In Stage 1, fecal samples from 150 goats were examined using simple flotation and sedimentation techniques to identify parasite morphology. In Stage 2, the McMaster technique was employed to quantify fecal egg counts (FEC). Twenty-six goats …

The Reluctance Of Physical Education Teachers To Teach In Special Education Schools From The Perspective Of Physical Education Students: Causes And Solutions, Noor T. Abu Sneneh, Rafi H. Asfour Dr., Tariq G. Raja Dr.

International Journal for Research in Education

This study aimed to examine why physical education teachers are reluctant to teach in special education schools from the perspective of physical education students at Birzet University. It also sought to explore possible solutions to this issue. A mixed-methods approach (quantitative and qualitative) was used, with a random sample of 110 physical education students (both male and female) and a purposive sample of five faculty members from the Department of Physical Education. Data were collected through questionnaires and interviews and analyzed using appropriate statistical and qualitative methods. The results showed that the level of reluctance among physical education teachers to …

Parenting Styles And Their Relationship To Cyberbullying Exposure Among High School Students: The Mediating Role Of Self-Confidence, Hesham F. Gadelrab Prof., Afnan H. Al-Muqate, Fatemah A. Al-Kandari

International Journal for Research in Education

This study examined the relationships among parenting styles, self-confidence, and cyberbullying exposure among high school students in Kuwait. It also explored differences in these variables by gender, grade level, and academic specialization, as well as the mediating role of self-confidence in the relationship between parenting styles and cyberbullying exposure. The study employed a descriptive correlational design and included 302 male and female students enrolled in the 11th and 12th grades across both science and literature tracks. Data were collected using the Self-Confidence Scale (Sanabani & Al-Tariq, 2020), the Parenting Styles Scale (Zugheer, 2007), and the Cyberbullying Scale (Hussein, 2018). The …

Intent Driven Network Aware Artificial Intelligence (Ai) Routing System With Distributed Ai Agents Using Multi-Layer Network Infrastructure, Jason Robert Ruben

Defensive Publications Series

A network-aware artificial intelligence (AI) control fabric is proposed herein for a system that bridges AI engineering and network engineering by using existing enterprise network infrastructure as the foundation of an intelligent, governed AI delivery fabric. The system dynamically routes AI agent workloads across distributed compute clusters based on intent classification, real-time network telemetry, policy constraints, wide area network (WAN) conditions, and compute availability. By treating the network as an active, programmable participant in each AI routing decision, the system provides a unified control plane for selecting appropriate AI agents, applying network policies, monitoring path health, and improving decisions through …

Public Interest In Salons And Spas With Islamic Nuances, Assyifa F. Adzani, Boike J. Anshory, Alifia W. Izzati, Pengiran Dr Hajah Norkhairiah Binti Pengiran Haji Hashim

Nusantara Halal Journal

This research is motivated by the increasing demand for women to be able to undergo beauty treatments safely and comfortably. In recent years, the salon and spa industry has played quite an important role in Indonesia. Caring for and beautifying oneself has become part of a person's lifestyle, especially in urban areas, including Muslim women. Generally, salons and spas are open to male and female customers. Still, in countries where most of the population is Muslim, many Muslim women want a room or area for those who wear hijabs to receive treatments at salons and spas freely. Muslimah salon is …

Concise And Informative Article Titled The Influence Of Islamic Modern Life On People's Visits To Places Of Reflexology, Andrea Angeline Hidayat, Boike Janus Anshory, Oktavianus Nangoy

Nusantara Halal Journal

Reflexology is a treatment that attempts to recover a body that is worn out, uncomfortable, or ill. Numerous health issues are emerging due to the modern lifestyle we presently live. The body could get physically and psychologically exhausted from daily activities, workplace physical activity, and other stressful situations. Muscle stiffness may happen from job responsibilities that are unmoved and lack movement. Activities that require a lot of muscle and body movement increase the risk of injuries to the body, including strains and sprains. Accuracy and focus during working or doing routine duties might be affected by mental tiredness. Modern life …

Exploring The Halal Perspectives On Animal Excrement And Its Renewable Energy Products, Ahmad Munjin Nasikh, Nur Faizin, Eli Hendrik Sanjaya, Achmad Sultoni, Cecep Soleh Kurniawan

Nusantara Halal Journal

Energy consumption continues to increase following the escalation of economic growth worldwide. The U.S. Energy Information Administration predicts global energy consumption will increase by 50% from 2018 to 2050, with the highest increase in Asia. But up to recently, coal and oil are still the primary sources of energy. Thus, a novel and renewable alternative energy is a necessity. Biomass is one of the most abundant renewable energy sources that come from various sources. However, the Muslim world population feels the need for an answer to the halal status of this energy source. This paper examines Islamic classical and modern …

Establishment Of Age-Specific Reference Intervals For Ca 19-9 And Cea: A Retrospective Analysis Of The Saudi Population, Abrar Ashi, Shmoukh Alghuraibi

The Journal of King Abdulaziz University: Science

Introduction: Accurate interpretation of serum marker measurements is essential in clinical laboratory practice. Carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are widely used biomarkers, yet their serum concentrations may be influenced by demographic and non-malignant factors. This study aimed to establish age- and gender-stratified reference intervals (RIs) for a Saudi population and quantify the impact of these local limits on diagnostic specificity and stewardship.

Methods: We retrospectively analysed 1,567 adult laboratory results (aged 15–100) from nationwide diagnostic centres. This study followed the CLSI EP28-A3c guidelines for the indirect estimation of reference intervals. Statistical analysis included Kruskal–Wallis and Mann–Whitney …

Integration Of Endemic Economic Cereal And Legume Crops In Jazan, Saudi Arabia Based On Pathogenic Fungi As A Taxonomic Study, A. El-Shabasy

The Journal of King Abdulaziz University: Science

This review evaluates the relation between fungal disease of the most important economic plants at Jazan region, Saudi Arabia and phylogenetic plant taxonomic values. This study provides the full information on the status of fungal diseases with comparative analysis among different species related to the same families. The review highlights on environmental impacts on fungal disease dispersion, virulence and pathogenicity besides the plant morphological characters. It refers to the adaptation of plants at their habitats as well as the status of fungal biodiversity among studied plant species.