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The Efficacy Of Ventral Pallidum- Deep Brain Stimulation In Rat Models Of Epilepsy, Fu Yee Chua

Biological Sciences

Antiepileptic drugs have been a primary option for patients with epilepsy worldwide, however, about one-third of patients do not respond to pharmacotherapy. For these individuals, resective surgery can be performed but seizures are still reported in some cases. With that in mind, neuromodulation or deep brain stimulation (DBS) is a plausible alternative to provide seizure freedom for refractory individuals. Vagus nerve stimulation (VNS), anterior thalamus DBS and responsive neurostimulation (RNS) are FDA approved as neuromodulatory approaches for epilepsy. They reduce and delay seizures but do not prevent or abolish seizures. In the previous study, the Shin lab showed that DBS …

Social Connectedness And Eating Disorder Symptomatology, Nicole Nunez

Psychology

Eating disorders are a well-known and well-documented issue with known deleterious effects on one’s health. Because of this fact, it is important to identify protective factors against the development and/or maintenance of eating disorders. Social support has been identified as a factor that can play a role in recovery from eating disorders. While the importance of social support has been broadly examined in research, social connectedness specifically has been explored less explicitly. Social connectedness involves feelings of belonging, identification with others, and healthy social interaction. This study sought to assess the role of social connectedness in eating disorder symptomatology. We …

Bayesian Analysis In Adult Skeletal Age-At-Death Estimation, With Additional Consideration Of Pathological Variables, Jessica L. Campbell

Legacy Theses & Dissertations (2009 - 2024)

A common task bioarchaeologists face is to estimate age-at-death in populations that have no corresponding documentation. This poses many challenges, the first of which is that age-at-death is highly variable within and among populations and can be further confounded by genetic and environmental influences, as well as other components of the biological profile. Estimating age-at-death in a historic sample can be even more challenging due to missing age indicators or taphonomic changes that obscure the features. Bayesian Analysis offers the potential to mitigate these challenges and to estimate age-at-death with lower degrees of uncertainty and higher probabilities of increased accuracy …

Of Donuts And Promo : In Silico Approaches To Identification Of Transcriptional Regulators Of Salivary Acinar Differentiation, Connor Cillian Duffy

Legacy Theses & Dissertations (2009 - 2024)

The salivary gland is an organ often taken for granted by most people. However, its proper function is essential for several everyday activities, such as speaking, swallowing, and tasting. As such, impaired salivary gland function, such as that caused by Sjögren’s Syndrome or radiotherapy for head and neck cancers, can lead to a significantly reduced quality of life. The cells that produce saliva in salivary glands are known as acinar cells, which arise from proacinar cells generated during embryonic development. As such, in studying the promoter regions of proacinar and acinar genes, it may be possible to identify common transcription …

Saliva As A Diagnostic Biological Fluid And The Human Salivary Proteome, Jessica Ghassan Emsies

Legacy Theses & Dissertations (2009 - 2024)

Saliva is a unique biologic fluid that contains a varying spectrum of proteins, nucleic acids, electrolytes, and hormones.31 It is an exocrine secretion of the salivary glands which is hypotonic in nature with a pH of 7.2-7.4.31 Saliva plays an important role in the oral cavity.33 It lubricates, hydrates, and bathes the oral cavity, therefore, aiding speech and mastication.33 Saliva forms a barrier on the teeth, protects against demineralization, and aids in remineralization.33 Saliva is required for chewing and food bolus preparation, it contains enzymes necessary for digestion, and mediates the sense of taste.33 It also helps wound healing and …

Migration, Resettlement, And Transition In The Aftermath Of The Maya Collapse : A Case Study Of A Terminal Classic Maya Community In Northern Belize, Josalyn M. Ferguson

Legacy Theses & Dissertations (2009 - 2024)

While there is consensus that the processes of decline and abandonment at many sites associated with the Terminal Classic Maya “collapse” (A.D. 750-1050) included the movement of peoples across the Maya lowlands, there has been little focused archaeological research on the resettlement and regeneration of these migrant groups. The movement of peoples across the Maya landscape was partially encouraged by a declining and ever increasingly taxed environment, as well as a revolution in exchange systems, with a notable increase in entrepreneurialism across the Maya subarea. This more integrated economic system focused on a wider range of commodities that served to …

The Role Of Rock Signaling On Salivary Gland Organoid Formation, Matthew Koslow

Legacy Theses & Dissertations (2009 - 2024)

Salivary glands are crucial organs that are responsible for secreting saliva which is important for the breakdown of carbohydrates, providing lubrication of the mouth, and maintenance of oral health. Patients diagnosed with Sjögren's Syndrome or receiving treatment for head and neck cancer, can permanently lose salivary gland function, which is referred to as salivary hypofunction. As a result, these patients develop Xerostomia, or the feeling of dry mouth, and suffer from an overall decreased quality of life. To combat the negative effects of salivary hypofunction, stem cell therapy is an attractive option, as implantation of specific cell populations can rescue …

Accumulation And Spatial Distribution Of Lead And Other Trace Elements In Keratinized Tissues : Investigations Based On Analytical Atomic Spectrometry, Mina W. Tehrani

Legacy Theses & Dissertations (2009 - 2024)

Human biomonitoring for toxic metals such as lead (Pb) provides information about absorbed dose from all exposure routes, and is critical for identifying exposed individuals and assessing health risks. Blood Pb and bone Pb are the primary validated biomarkers for assessing short-term and historical Pb exposures, respectively, while non-traditional matrices, including keratinized tissues, can provide complementary exposure information. Hard keratinized tissues – including hair, nails, hooves, and horns – grow incrementally, potentially preserving chemical exposure histories over a span of days to years. Analytical limitations and poor interlaboratory reproducibility, however, have led to debate around the use of human nails …

Examining The Influence Of Technology Affordances Of Fitness Trackers And Health Psychographic Factors On Physical Activity, Xin Zhou

Legacy Theses & Dissertations (2009 - 2024)

Fitness trackers have immense potential to improve individuals’ health behaviors and health outcomes. Studies in disciplines such as public health, communication technology and information systems, have examined factors that can predict use of fitness trackers and their influence on health-related behaviors. However, not much is known about (1) which element(s) of fitness trackers affect individuals’ health behaviors, and (2) the psychological mechanism that guides the relationships between individuals’ health-related beliefs and use of fitness trackers on physical activity behaviors. Guided by the Motivational Technology Model (MTM) and Self-Determination Theory (SDT), this dissertation examined the influence of technology affordances (i.e., customization, …

University At Albany Stars Report, University At Albany, State University Of New York

STARS reports

Gold Rating: STARS Version 2.1

The Sustainability Tracking, Assessment & Rating System (STARS®) is a transparent, self-reporting framework for colleges and universities to gauge relative progress toward sustainability. STARS was developed by AASHE with broad participation from the higher education community.

STARS is designed to:

• Provide a framework for understanding sustainability in all sectors of higher education.

• Enable meaningful comparisons over time and across institutions using a common set of measurements developed with broad participation from the campus sustainability community.

• Create incentives for continual improvement toward sustainability.

• Facilitate information sharing about higher education sustainability practices and …

Copyright, Digitization, & Rfid

JLAMS

No abstract provided.

Effects Of Zinc On Cognition, Anthony Piche

Biological Sciences

Insulin resistance is the defining symptom of type 2 diabetes and a key risk factor for Alzheimer’s disease. Work from our lab and others has shown that insulin is a key component of brain pathways mediating cognition; specifically, mechanisms that transduce hippocampal memory processing. In the hippocampus, insulin regulates glucose metabolism through translocation of the glucose transporter GluT4 and modulates several other molecular cascades. Studies where insulin is studied as a cognitive modulator have generally used a formulation that contains zinc to stabilize insulin. However, zinc itself modulates molecular signaling pathways including AKT and GSK3β, which are both downstream of …

Fgf2-Dependent Mesenchyme And Laminin-111 Are Niche Factors In Salivary Gland Organoids, Zeinab F. Hosseini, Deirdre A. Nelson, Nicholas Moskwa, Lauren M. Sfakis, James Castracane, Melinda Larsen

Biological Sciences Faculty Scholarship

Epithelial progenitor cells are dependent upon a complex 3D niche to promote their proliferation and differentiation during development, which can be recapitulated in organoids. The specific requirements of the niche remain unclear for many cell types, including the proacinar cells that give rise to secretory acinar epithelial cells that produce saliva. Here, using ex vivo cultures of E16 primary mouse submandibular salivary gland epithelial cell clusters, we investigated the requirement for mesenchymal cells and other factors in producing salivary organoids in culture. Native E16 salivary mesenchyme, but not NIH3T3 cells or mesenchymal cell conditioned medium, supported robust protein expression of …

How Single-Payer Stacks Up: Evaluating Different Models Of Universal Health Coverage On Cost, Access And Quality,, Ashley Fox, Roland Poirier

Public Administration and Policy Faculty Scholarship

Described as “universal prepayment,” the national health insurance (or single-payer) model of universal health coverage is increasingly promoted by international actors as a means of raising revenue for health care and improving social risk protection in low- and middle-income countries. Likewise, in the United States, the recent failed efforts to repeal and replace the Affordable Care Act have renewed debate about where to go next with health reform and arguably opened the door for a singlepayer, Medicare-for-All plan, an alternative once considered politically infeasible. Policy debates about single-payer or national health insurance in the United States and abroad have relied …

The Influence Of Submandibular Salivary Gland Mesenchyme On The Proacinar Epithelial Cell Phenotype, Zeinab Farajallah Hosseini

Legacy Theses & Dissertations (2009 - 2024)

Current treatments for patients suffering from salivary hypofunction are insufficient and there is clinical need for regenerating the damaged tissue and restoring function of the gland. Reconstruction of 3D architecture is essential for stimulating secretory differentiation of epithelial progenitor cells in the salivary gland, which involves input from extracellular matrix and basement membrane as well as heterotypic cell interactions. However, the specific requirements for differentiation of secretory progenitor cells in salivary glands remain unclear. To determine what mechanisms and factors are required to promote proacinar differentiation, we isolated primary epithelial cells from embryonic day 16 (E16) submandibular salivary gland (SMG) …

Nutrition Transition, Trace Elements In Nails, And Blood Pressure Along The Interoceanic Highway, Madre De Dios, Peru, Stacy M. Pettigrew

Legacy Theses & Dissertations (2009 - 2024)

The paving of the Interoceanic Highway (IOH) brought rapid development to the Madre de Dios (MDD) region in the Peruvian Amazon. Development brings concerns of toxic trace element exposures, and road development has been a major driver of the transition from traditional to calorie-dense processed ‘Western’ diets in lower and middle-income countries. Investigacion de Migracion, Ambiente, y Salud (IMAS) (Investigation of Migration, the Environment, and Health) is the first analysis of health, diet, and integrated toxic trace elements in nails in the region. In 2014 we collected household surveys from 310 households in 46 communities along the IOH and nails …

Factors Associated With Candida Albicans Dissemination Via The Intestinal Mucosa, Emily Rochac Argueta

Legacy Theses & Dissertations (2009 - 2024)

A murine model that established GI colonization of Candida albicans and eventual dissemination was identified to be lacking by Koh and others. Koh’s model specifically employed a tailored combination of neutropenia, intestinal damage, and microbiome dysbiosis that would allow C. albicans to gain an opportunistic advantage. His model provided new opportunities to study the details of C. albicans pathogenesis with a focus on the innate immune mechanisms responsible for controlling C. albicans within the intestinal mucosa. The long-term goal of this research project was to specifically study the factors associated with Candida albicans dissemination via the intestinal mucosa. The model …

Psychological Reactance Theory And Marijuana Craving, Melissa Nicole Slavin

Legacy Theses & Dissertations (2009 - 2024)

Psychological Reactance Theory (Brehm, 1966) asserts that people experience reactance (a retaliatory motivational state characterized by negative affect and resistant attitudes) when they perceive their autonomy is threatened. Reactance may lead to “boomerang effects”, where the individual is drawn toward the restricted object or behavior. Anti-marijuana (MJ) messages designed to discourage use might heighten reactance and inadvertently lead to greater craving for MJ and stronger intentions to use. The current online experiment determined that a message discouraging use of MJ evoked greater reactance in student and community member participants than a harm-reduction message. Additionally, reactance was associated with participants’ indirect …

Differentiation Of Potential False Positives From Human Saliva Using Raman Spectroscopy For Forensic Purposes, Selina Casadei

Legacy Theses & Dissertations (2009 - 2024)

Traces of body fluids can be found at a crime scene. Being able to identify and differentiate the body fluids while preserving DNA is fundamentally important for forensic applications. Saliva is an important body fluid that can be found on bite marks, cigarette butts, and more, being an excellent source for DNA extraction. Current tests for saliva and other body fluids are destructive and body fluid specific, and are prone to false positives. Our laboratory has developed a universal method for identification of all main body fluids; saliva, semen, sweat, peripheral blood, and vaginal fluid, using Raman spectroscopy combined with …

Changes In Body Fatness Among Mohawk Youth From 1979 To 1996-2000, Danielle Maria Garry

Anthropology

The research question is: Have the Mohawk people been affected by the obesity epidemic that has occurred in this country and globally? My research compares the data on height, weight, and skinfold thicknesses collected from 1979 by Dr. Susan Pfeiffer from Native American youth (10 to 15 years of age) of the Akwesasne tribe, located at St. Regis, with similar data collected by Gallo and Schell, from 1996-2000. I performed t-tests to compare the same measurements from the two studies. There is a significant difference in weight, triceps skinfolds, and subscapular skinfolds in all male age groups except for age …

Hiv In New York City: An Overview Of Cultural And Social Factors Contributing To An Individual's Decision To Disclose Their Disease Status, Lindsey Riback

Public Health Undergraduate Program

will examine what effect cultural norms surrounding race and sexual orientation, as well as four specific social factors (alcohol use during sex, injection drug use, social support and the importance of religion) have on whether an HIV positive individual, specifically an urban homosexual male, chooses to disclose their disease status. This paper will discuss those cultural norms and social factors through the AIDS Risk Reduction Model, available literature, and the data collected by the National Institute of Mental Health for the Positive Connections intervention trial. The data for this paper were pulled from the larger study, and only the 171 …

Culturally And Linguistically-Adapted School Systems: A Study Of Promising Practices In Odds-Beating Elementary Schools, Kristen Campbell Wilcox, Karen Gregory, Fang Yu

Educational Policy & Leadership Faculty Scholarship

This multiple case study investigated characteristics of six elementary schools in New York State with statistically significant better performance outcomes among their English language learner (ELL) students. Through documentary evidence, classroom observations, and interviews with students, teachers, and administrators, a system-wide approach to adaptations that benefit ELL students was identified. These adaptations were evident in: (a) school cultures that embrace ideals of equity of opportunity and celebrate diversity; (b) school climates that evoke a sense of safety and welcome; and (c) processes and practices that support advocacy for ELLs and their families. While the schools shared these common characteristics, educators …

Factors Associated With Successful Completion Of A Transitional Living Program For Homeless And Former Foster Youth, Megan Brophy-Mclean

Legacy Theses & Dissertations (2009 - 2024)

Transitional and Independent Living programs exist to help prepare homeless, at-risk and foster youth to live independently in the community as adults at an age earlier than expected from more privileged youth. The challenges they face often result in poor outcomes such as ongoing homelessness, substance abuse problems, low levels of education, and high levels of unemployment. Because the stakes are so high for these youth, it is imperative that the programs designed to help them are able to meet their needs by having them remain in the program until they are competent to live independently. This study attempts to …

Inequality In Access To Dental And Vision Care : Examining The Role Of Income And Insurance, Wahida Ferdousi

Legacy Theses & Dissertations (2009 - 2024)

This dissertation explores inequality in access to dental and vision care. It includes three chapters.

The History Of Forensic Science In The State Of New York, Elke Hof-Kenyon

Legacy Theses & Dissertations (2009 - 2024)

This dissertation delineates the process and advancements in professionalizing the police departments and the development of forensic science in New York. Furthermore, as a preliminary and exploratory study it examines the evolution and changes of forensic science within the growth and expansion of a New York county police department. The relationship between police and forensic science was complex; for example, the impetus for the police to adopt a particular forensic methodology varied. At times, the development of forensic methodologies necessitated a further step in professionalizing the police departments. Other times, law enforcement sought new forensic inventions, or the improvement of …

Novel Approaches To Mitigating Bacterial Biofilm Formation And Intercellular Communication, Stephen Kasper

Legacy Theses & Dissertations (2009 - 2024)

Long thought of as solitary single-cell organisms, it is now widely accepted that bacteria can act and cooperate as social organisms. Phenomena such as biofilm formation and quorum sensing (QS) are two intimately intertwined cooperative behaviors that significantly contribute to the pathogenesis of many bacteria. Biofilms are surface associated communities of bacteria encased in a secreted extracellular matrix, which provides several advantages over an individualized lifestyle, such as increased protection from antimicrobial agents as well as enhanced opportunity for the exchange of genetic material. Bacterial QS is a system of population-based communication through the production, sensing, and response to chemical …

A Study Of Sociolinguistic Variation In A Small Community : Puerto Rican Spanish In Amsterdam, New York, Zahir Mumin

Legacy Theses & Dissertations (2009 - 2024)

The objective of the current study is to contribute to the larger body of sociophonetic variation research by describing and analyzing Spanish as spoken in a small Puerto Rican community in the US. First, I describe phonological and morphosyntactic features of Spanish as used by four different groups of Puerto Rican informants in Amsterdam, New York based on the duration of time that they have lived on the Island of Puerto Rico. Previous research on Puerto Rican Spanish in the US has focused particularly on final /s/ deletion (Poplack, 1980b, 1980c), final liquid production of /l/ and /ɾ/ (Ramos-Pellicia, 2007), …

Child Abuse In The Archaeological Context, Nicole Marie Popielarz

Legacy Theses & Dissertations (2009 - 2024)

Children have been a widely ignored subject in archaeology so it follows that child abuse has not been studied in detail in the archaeological context. This paper combines both forensic anthropology studies and Bioarchaeological studies to see if child abuse is a modern phenomenon. Signs of both non-accidental trauma and neglect have been documented by authors in the archaeological record. The purpose of this paper will be to describe signs of both nonaccidental trauma and neglect. Then examples in archaeological studies will be reviewed. The future of the study of abuse in the archaeological context is also discussed at some …

Understanding Trait-Turnover Relationships : An Examination Of The Utility Of Holland's Congruence Theory And The Riasec Typology, Sarah Rebecca Strahan

Legacy Theses & Dissertations (2009 - 2024)

The goal of the current study is to improve our understanding of the relationship between personality and employee turnover. Research is reviewed to demonstrate that after decades of research we still know very little about the role of personality in turnover. As a result, many researchers have called for new approaches to improve our understanding of the relationship between personality and turnover (Griffeth, Hom, & Gaertner, 2000; Hom & Griffeth, 1995; Russell, 2013). One approach that has received little attention is examining whether job context matters –that is, do the traits that predict employee turnover depend on the particular job. …

Sources, Pathways, And Distribution Of Bisphenol A Diglycidyl Ether (Badge) And Its Derivatives In The Environment, Jingchuan Xue

Legacy Theses & Dissertations (2009 - 2024)

BADGE (bisphenol A diglycidyl ether) based epoxy resins have been used in a variety of applications since the 1940s. However, limited studies are available about the occurrence of BADGE and its derivatives (BADGEs) in the environment. The aims of this thesis were to determine the concentrations of BADGE and its derivatives in dental sealants and textile products from the U.S. to characterize the sources of these substances. Furthermore, concentrations of BADGEs in samples from various stages of waste water treatment plants (WWTPs) in the U.S. were also determined to investigate the environmental pathway and fate of these substances. BADGEs were …