Digital Commons Network^™

Suppression Of Progranulin Expression Inhibits Bladder Cancer Growth And Sensitizes Cancer Cells To Cisplatin., Simone Buraschi, Shi-Qiong Xu, Manuela Stefanello, Igor Moskalev, Alaide Morcavallo, Marco Genua, Ryuta Tanimoto, Ruth Birbe, Stephen C. Peiper, Leonard G. Gomella, Antonino Belfiore, Peter C. Black, Renato V. Iozzo, Andrea Morrione

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth. Progranulin also induces F-actin remodeling by interacting with the F-actin binding protein drebrin. In addition, progranulin is overexpressed in invasive bladder cancer compared to normal tissue controls, suggesting that progranulin might play a key role in driving the transition to the invasive phenotype of urothelial cancer. However, it is not established whether targeting progranulin could have therapeutic effects on bladder cancer. In this study, we stably depleted urothelial …

Franklin Delano Roosevelt: The Diagnosis Of Poliomyelitis Revisited., John F. Ditunno, Jr, Bruce E. Becker, Gerald J. Herbison

Department of Rehabilitation Medicine Faculty Papers

Revisiting the ailments of famous historical persons in light of contemporary medical understanding has become a common academic hobby. Public discussion of Franklin Delano Roosevelt's (FDR) diagnosis of poliomyelitis after his sudden onset of paralysis in 1921 has received just such a revisitation. Recently, this 2003 historical analysis has been referenced widely on the Internet and in biographies, raising speculation that his actual diagnosis should have been Guillain-Barré Syndrome, a noncontagious disease of the peripheral nervous system rather than poliomyelitis. The authors of that 2003 analysis used a statistical analysis of his case by selectively choosing some of his reported …

Parental And Staff Perspectives Of Nicu Research Procedures., Christina Freibott, Ursula Guillen, Amy Mackley, Robert Locke

Department of Medicine Faculty Papers

BACKGROUND: There are limited data on parental perception of infant participation in minimal risk and minor increase above minimal risk research focusing on the NICU population. The study objective was to assess parental and NICU staff perceptions concerning minimal risk and minor increase above minimal risk in the NICU setting.

METHODS: Parents of infants and NICU staff were presented with a combination of 4 infant scenarios and 5 hypothetical research procedures. These assessed participants' willingness to allow their infant to participate in research and their attitude towards obligation to assist future children. Linear and hierarchal linear models analyzed the association …

Stand Tall, Don’T Fall: A Systematic Review On The Effectiveness Of Tai Chi For Improving Balance In Healthy Older Adults, Miya Cho, Ots, Moira Frain, Ots, Courtney Monk, Ots, Caitlin O'Neill, Ots, Kathryn Ricciardi, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives:

•Identify and describe the need for effective balance related interventions among the healthy older adult population

• Recognize occupational therapy’s role in improving balance to decrease risk of falls

• Discuss the effectiveness of Tai Chi as an intervention for improving balance within this population

PICO

• Is Tai Chi an effective intervention for improving balance in the healthy older adult population?

Presentation: 40:55

Handout at bottom of page.

Reframe The Pain: A Systematic Review Of Occupational Therapy Interventions To Promote Quality Of Life For Adults With Fibromyalgia, Alyssa Armstrong, Ots, Jonathan Forkin, Ots, Emma Jablonski, Ots, Shelby Moyer, Ots, Suzanne Sager, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives:

1. Define clinical presentation and three common characteristics of fibromyalgia (FMS) as it impacts quality of life (QOL).

2. Recognize the importance of an occupational therapy (OT) approach as an alternative to current practice methods.

3. Identify at least three effective EBP interventions within the scope of OT to address quality of life for individuals with FMS.

PICO:

What is the evidence to support the effectiveness of interventions within the scope of OT on improving quality of life for adults diagnosed with fibromyalgia?

Presentation: 43:56

Handout with references at bottom of page.

Keeping Up With The Preemies: Early Interventions In Occupational Therapy For Children Born Premature, Jennifer Donnelly, Ots, Angela Mancini, Ots, Heidi Miller, Ots, Taylor Vile, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives:

1. Identify areas of occupational performance that may be impacted by premature birth.

2. Understand current themes of interventions for promoting development after premature birth.

3. Apply evidence-based practice to interventions for children born prematurely.

PICO:

What is the evidence to support the use of early interventions in the scope of OT to promote development in children born prematurely?

Presentation: 53:18

Lasers In Tattoo And Pigmentation Control: Role Of The Picosure(®) Laser System., Richard Torbeck, Richard Bankowski, Sarah Henize, Nazanin Saedi

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND AND OBJECTIVES: The use of picosecond lasers to remove tattoos has greatly improved due to the long-standing outcomes of nanosecond lasers, both clinically and histologically. The first aesthetic picosecond laser available for this use was the PicoSure(®) laser system (755/532 nm). Now that a vast amount of research on its use has been conducted, we performed a comprehensive review of the literature to validate the continued application of the PicoSure(®) laser system for tattoo removal.

STUDY DESIGN AND METHODS: A PubMed search was conducted using the term "picosecond" combined with "laser", "dermatology", and "laser tattoo removal".

RESULTS: A total …

Childhood Psychosocial Determinants Of Cardiovascular Health, Samuel S. Gidding, Erica D. Sood

Department of Medicine Faculty Papers

Understanding risk and protective factors that impact cardiovascular health is of utmost importance. There is ample evidence that cardiovascular health begins in childhood, tracks over time, and is subject to adverse social influences. This paper reviews key studies examining the relations of psychosocial factors in childhood to cardiovascular health in adulthood. The existing literature provides evidence for both individual and cumulative effects of childhood psychosocial factors on adult cardiovascular health across the population, although the specific mechanisms underlying these relationships are not yet fully understood. This paper also includes a discussion of evidence-based strategies for prevention and treatment of childhood …

Integrating Correctional And Community Health Care: An Innovative Approach For Clinical Learning In A Baccalaureate Nursing Program., Mary T. Bouchaud, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

PROBLEM: With an evolving focus on primary, community-based, and patient-centered care rather than acute, hospital-centric, disease-focused care, and recognition of the importance of coordinating care and managing transitions across providers and settings of care, registered nurses need to be prepared from a different and broader knowledge base and skills set. A culture change among nurse educators and administrators and in nursing education is needed to prepare competent registered nurses capable of practicing from a health promotion, disease prevention, community- and population-focused construct in caring for a population of patients who are presenting health problems and conditions that persist across decades …

Evaluating The Decision Making Process Of Pediatricians' Recommendations For First Complementary Foods In Infants, Gretchen Schmoyer

Master of Public Health Capstone Presentations

The purpose of this research study was to document the feeding guidelines from medical associations, understand what pediatricians are recommending to new mothers, and to capture the response from mothers regarding their understanding and personal practices in feeding. Previous studies have found that mothers were not following feeding recommendations by the American Academy of Pediatrics (AAP). Furthermore, the role of infant rice cereal as an early first food is currently under debate. Qualitative research was conducted through interviews with five mothers of children under 2 years, five healthcare providers in pediatric settings, and three policy experts. The Theory of Reasoned …

Advances In Allograft Monitoring After Intestinal Transplantation., Augusto Lauro, Md, Phd, Ignazio R. Marino, Md, Scd, Cal S. Matsumoto, Md

Department of Surgery Faculty Papers

PURPOSE OF REVIEW: The intestinal allograft, with an enormous lymphoid load, is a highly immunogenic organ which elicits a strong alloimmune response. In the early posttransplant period, a robust graft biopsy protocol via a temporary ileostomy is utilized for surveillance to detect rejection. In the later posttransplant period, after enteral continuity is reestablished, graft biopsies via a colonoscopy become more cumbersome. Alternative methods for intestinal allograft monitoring other than graft biopsy are of particular interest.

RECENT FINDINGS: Biomarkers and diagnostic tools, such as granzyme B, perforin, fecal calprotectin, citrulline, donor-specific antibody, and zoom video endoscopy have all been studied for …

Scitech News Volume 70, No. 1 (2016)

Sci-Tech News

Columns and Reports

From the Editor 3

SciTech News Call for Articles 3

Assistant Editor wanted 4

Division News

Science-Technology Division 5

Chemistry Division 7

Engineering Division 12

Aerospace Section of the Engineering Division 13

Call for Nominations & Applications

Sparks Award for Professional Development11

Reviews

Sci-Tech Book News Reviews 15

Design Of Barrier Coatings On Kink-Resistant Peripheral Nerve Conduits., Basak Acan Clements, Jared Bushman, N. Sanjeeva Murthy, Mindy Ezra, Christopher M. Pastore, Joachim Kohn

Kanbar College Faculty Papers

Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of the conduit. This problem can be controlled by the application of secondary barrier coatings. Using a critical size defect in a rat sciatic nerve model, the importance of controlling the porosity of the nerve conduit walls was explored. Braided conduits without barrier coatings …

Locomotor Training In The Pediatric Spinal Cord Injury Population: A Systematic Review Of The Literature, Katelin Gorski, Spt, Kelsey Harbold, Spt, Katelyn Haverstick, Spt, Emily Schultz, Spt, Stephanie E. Shealy, Ms, Spt, Laura Krisa, Phd

Department of Physical Therapy Capstone Posters

Purpose:

The aim of this review was to investigate the effects of locomotor training on pediatric SCI and develop recommendations for pediatric LT guidelines.

The Effect Of Night Splints In The Treatment Of Plantar Fasciitis: A Systematic Literature Review, Kelly Boatwright, Spt, Thomas Hutchinson, Spt, Alyssa Saurman, Spt, Ernesto Méndez, Spt, Christopher Wanyo, Spt, Paul Howard, Pt, Dpt, Phd, Ocs, Faaompt

Department of Physical Therapy Capstone Posters

Objective:

To investigate the use of night splints for the treatment of plantar fasciitis and the current evidence regarding their ability to affect symptoms associated with plantar fasciitis.

The Most Effective And Efficient Bedside Exam For The Dizzy Patient In The Acute Care Setting: A Systematic Review Of The Literature, Alexandra Davis, Spt, Katierae Hunsicker, Spt, Cathy Lee, Spt, Megan Shultz, Spt, Janette Scardillo, Pt, Dpt, Cbis

Department of Physical Therapy Capstone Posters

Purpose:

The purpose of this systematic review of the literature (SRL) is to evaluate the effectiveness and efficiency of vestibular bedside tests for patients with complaints of dizziness and vertigo in the acute care setting. This includes differentiating between a central and peripheral disorder, as well as diagnosing peripheral disorders within the scope of physical therapy practice

Does High-Intensity Exercise Better Improve Ambulation In The Population With Chronic Stroke, As Compared To Standard Care?: A Systematic Review Of The Literature, Caitlin Caruso, Spt, Courtney Comstock, Spt, Ashley Mckenna, Spt, Samantha Nixon, Spt, Ashley Wonneberger, Spt, Christine M. Tyrell, Pt, Phd, Ncs

Department of Physical Therapy Capstone Posters

Purpose:

To assess the effectiveness of high-intensity exercise on the improvement of gait deficits in survivors of chronic stroke as compared to standard care.

Application Of Dual Task Performance In Pediatrics And Adults With Traumatic Brain Injury: A Systematic Review, Lauren Bilski, Kathleen Clancy, Victoria Dean, Danielle Melfi, Kristin Reardon, Louis N. Hunter, Pt, Dpt

Department of Physical Therapy Capstone Posters

Purpose:

The aim of this systematic review of the literature is to investigate the application of cognitive and motor dual task paradigms in the physical therapy management of moderate to severe TBI population across the lifespan in physical therapy practice.

Grace Spena, Grace Spena, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Grace Spena grew up with an interest in health sciences, first wanting to be a medical laboratory technologist and later a registered nurse after attending an open house on nursing at Saint Agnes Hospital, where she volunteered as a teenager. Upon completing her education in 1971 from the Jefferson Diploma School of Nursing, Ms. Spena began her career as a Staff Nurse in the Surgical ICU at Jefferson Hospital. She then went to Medical College of Pennsylvania, working as a Staff Nurse in the combined Medical/Surgical ICU and later as the Head Nurse of the 3 West Medical/Surgical unit. After …

Reducing Gastrointestinal Anastomotic Leak Rates: Review Of Challenges And Solutions, Benjamin Philllips

Department of Surgery Faculty Papers

Various techniques and interventions have been developed in an effort to obviate gastrointestinal anastomotic leaks. This review is intended to delineate potential modifications that can be made to reduce the risk of anastomotic leaks following gastrointestinal surgery. It may also serve to aid in identifying patients who are at increased risk of anastomotic leak. Modifiable risk factors for leak discussed include malnutrition, smoking, steroid use, bowel preparation, chemotherapy, duration of surgery, use of pressors, intravenous fluid administration, blood transfusion, and surgical anastomotic technique. Based upon literature review, operative techniques should include minimizing operative time, reducing ischemia, and utilizing stapled anastomoses. …

Feedback: Helping Learners Grow, Nina Mingioni, Md, Tasha Kouvatsos, Md

Medical Education Teaching Tools

Learning Objectives

1. Understand the role of feedback in medical education
2. Learn several models for delivering feedback
3. Develop list of go-to activities that would prompt feedback delivery
4. Practice feedback delivery skills

Program In Faculty Development 2016-2017

Program in Faculty Development

Welcome to a new academic year and to opportunities to improve your skills as an educator, scholar and leader in the academic health professions! This booklet will provide you with information about the TJU Faculty Development Program for the 2013–2014 academic year including course listings, registration information, and general program information. This booklet features two “At-a-glance” outlines of the faculty development programs: a course outline for each of the three faculty development program focus areas (education, research/scholarship, and professional development and leadership) and a month-by-month calendar of activities. Detailed program information for each focus area follows. The faculty development programs …

Feminist Fissures: Navigating Conflict In Mentoring Relationships, Kathryn Gindlesparger, Holly Ryan

College of Humanities and Sciences Faculty Papers

Scholarship in rhetoric and composition has richly addressed the role of feminist mentoring and how a feminist perspective of mentoring might work across various mentoring configurations. However, there is little feminist rhetorical scholarship that discusses the transition from a graduate mentoring group to a faculty mentoring group. This case study examines how one group navigated the change from graduate mentors to faculty mentors, revealing how unarticulated conflict lead to the end of the relationships. In unpacking this narrative, this article argues that feminist mentoring scholarship has not done enough to openly discuss the role of conflict in mentoring. Lacking scholarship …

Desigining An Executive Leadership Institute, John Pourdehnad, Phd, Larry Starr, Phd

School of Continuing and Professional Studies Faculty Papers

This report is the result of a combined effort between Greater Philadelphia Senior Executive Group (GPSEG) and the Doctor of Management in Strategic Leadership (DSL) Program at Thomas Jefferson University (TJU). The objective is to utilize a four phase method, informed by systems thinking and design methodology, to successfully define, design, and develop workshops/educational experiences for leaders wherein they identify, gain, or enhance the necessary capabilities needed for not only today’s but tomorrow’s complex and dynamic business environment within our global knowledge economy. Key stakeholders were identified and invited to participate in a design workshop on April 14, 2016 at …

Cogstate Computerized Memory Tests In Patients With Brain Metastases: Secondary Endpoint Results Of Nrg Oncology Rtog 0933., Chip Caine, Snehal Deshmukh, Vinai Gondi, Minesh Mehta, Wolfgang Tomé, Benjamin W. Corn, Andrew Kanner, Howard Rowley, Vijayananda Kundapur, Albert Denittis, Jeffrey Noah Greenspoon, Andre A. Konski, Glenn S. Bauman, Adam Raben, Wenyin Shi, Merideth Wendland, Lisa Kachnic

Department of Radiation Oncology Faculty Papers

Whole brain radiotherapy (WBRT) is associated with memory dysfunction. As part of NRG Oncology RTOG 0933, a phase II study of WBRT for brain metastases that conformally avoided the hippocampal stem cell compartment (HA-WBRT), memory was assessed pre- and post-HA-WBRT using both traditional and computerized memory tests. We examined whether the computerized tests yielded similar findings and might serve as possible alternatives for assessment of memory in multi-institution clinical trials. Adult patients with brain metastases received HA-WBRT to 30 Gy in ten fractions and completed Hopkins Verbal Learning Test-Revised (HVLT-R), CogState International Shopping List Test (ISLT) and One Card Learning …

Surgical Intensivist And Global Critical Care: Is There A Role?, Jana B.A. Macleod, Orlando C. Kirton, Linda L. Maerz

Abington Jefferson Health Papers

No abstract provided.

Karen Jordan, Karen Jordan, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Born and raised in Philadelphia, Karen Jordan was a member of the civil rights movement in Philadelphia during the 1960s, first becoming involved with the fight to desegregate Girard College. After a semester at Cheyney University Ms. Jordan took time away from school before deciding to study nursing. She enrolled in the Jefferson Diploma Nursing program in 1973 and graduated in 1976. She would later go on to also receive her Bachelor’s in Nursing Science, also from Thomas Jefferson University. Ms. Jordan has spent her long career at Jefferson working as a medical-surgical, oncology, and neonatal nurse. In her free …

Mary Woltemate Stec, Mary Woltemate Stec, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Dr. Stec began her nursing career in 1973 as a graduate of Jefferson’s Nursing Diploma School. She would go on to receive her BS in Nursing from the University of Pennsylvania, her MSN from Gwynedd Mercy College, and her PhD in Nursing from Widener University. Dr. Stec has spent the majority of her career as a nursing educator, including as an instructor at Thomas Jefferson University Hospital School of Nursing, Gwynedd Mercy College, and Abington Memorial Hospital Dixon School of Nursing. She is now an Assistant Professor at Temple University. She is also a Certified Nurse Educator, an Evaluator for …

African American Graduates Of Jefferson Medical College: The First Hundred Years, F. Michael Angelo

Posters: Jefferson History

Beginnings…

The story of early African American physicians begins in 18th century Philadelphia with James Derham who is recognized as the first black allopathic (regular, non-sectarian) medical doctor. The first medical school in the U.S. to admit an African American was Rush Medical College in Chicago that awarded, in 1847, David J. Peck his degree. Dr. Peck came to the “Quaker City” to set up his practice the same year that the A.M.A. was formed, also here in Philadelphia. In 1877, Jefferson doctors protested the seating of the delegates from Howard University, the nation’s most important black medical school, in …

Latin Heritage Month. Carlos Juan Finlay: Outrageous, Courageous And Correct, Dorothy E. Berenbrok

Posters: Jefferson History

In 1855, a modest Cuban physician named Carlos Juan Finlay graduated from Jefferson Medical College. He was among JMC’s first dozen Hispanic graduates, initially signing the registrar’s log as “Charles”. He left Philadelphia at the age of 22 to begin private practice. Preceptor and close friend S. Weir Mitchell, among others, urged Finlay to work among the burgeoning Spanishspeaking population in New York City, but he returned to Cuba and set up practice in Matanzas, a town near Havana. He took a binocular microscope with him, similar to one used byMitchell, which would serve him well for many years.

During …