Digital Commons Network^™

Low-Dose Versus Standard-Dose Tissue Plasminogen Activator In Acute Ischemic Stroke In Asian Populations: A Meta-Analysis., Meng-Dong Liu, Wei-Dong Ning, Ren-Cong Wang, Wei Chen, Yang Yang, Yan Lin, Da-Hai Hu, Wayne Bond Lau, Yan Qu

Department of Emergency Medicine Faculty Papers

Recent studies have investigated the most efficacious dose of intravenous tissue plasminogen activator (IV-tPA) for acute ischemic stroke (AIS) patients. There remains no definitive consensus concerning the superior efficacious IV-tPA dose (standard- vs. low-dose), prompting us to perform a meta-analysis comparing the efficacy and safety profile of standard- versus low-dose IV-tPA.We identified relevant studies pertaining to the specific aim of our meta-analysis by searching PubMed and EMBASE (January 1990-September 2015) Either a fixed- or random-effects model was employed (dependent upon data heterogeneity) to analyze the efficacy and safety outcome.Ten cohort studies involving 4389 sum patients were included in the meta-analysis. …

Confirmatory Factor Analysis And Invariance Testing Between Blacks And Whites Of The Multidimensional Health Locus Of Control Scale., Marianna Lanoue, Abby Harvey, Dawn B. Mautner, Bon Ku, Kevin Scott

Department of Family & Community Medicine Faculty Papers

The factor structure of the Multidimensional Health Locus of Control scale remains in question. Additionally, research on health belief differences between Black and White respondents suggests that the Multidimensional Health Locus of Control scale may not be invariant. We reviewed the literature regarding the latent variable structure of the Multidimensional Health Locus of Control scale, used confirmatory factor analysis to confirm the three-factor structure of the Multidimensional Health Locus of Control, and analyzed between-group differences in the Multidimensional Health Locus of Control structure and means across Black and White respondents. Our results indicate differences in means and structure, indicating more …

Fibronectin Signals Through Integrin Α5Β1 To Regulate Cardiovascular Development In A Cell Type-Specific Manner., Dongying Chen, Xia Wang, Dong Liang, Julie Gordon, Ashok Mittal, Nancy Manley, Karl Degenhardt, Sophie Astrof

Department of Medicine Faculty Papers

Fibronectin (Fn1) is an evolutionarily conserved extracellular matrix glycoprotein essential for embryonic development. Global deletion of Fn1 leads to mid-gestation lethality from cardiovascular defects. However, severe morphogenetic defects that occur early in embryogenesis in these embryos precluded assigning a direct role for Fn1 in cardiovascular development. We noticed that Fn1 is expressed in strikingly non-uniform patterns during mouse embryogenesis, and that its expression is particularly enriched in the pharyngeal region corresponding with the pharyngeal arches 3, 4, and 6. This region bears a special importance for the developing cardiovascular system, and we hypothesized that the localized enrichment of Fn1 in …

Emerging Immunopharmacological Targets In Multiple Sclerosis., Mojtaba Farjam, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami

Department of Neurology Faculty Papers

Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the major pathogenic mechanism of MS involves myelin-reactive T cell activation in the periphery and migration into the CNS, which subsequently triggers an inflammatory cascade that leads to demyelination and axonal damage. Virtually all MS medications now in use target the immune system and prevent tissue damage by modulating neuroinflammatory processes. Although current therapies such as commonly prescribed disease-modifying medications decrease the relapse rate …

Prevalence Of Health-Related Quality Of Life (Hrqol) In Asian Americans, Hee-Soon Juon, Phd, Frederic Kim, Ms, Seon Yoon Chung, Msn, Sunmin Lee, Scd

Department of Medical Oncology Posters

Objectives

To report the prevalence of Health Related Quality of Life (HRQOL) in foreign-born Asian Americans (AA) and to compare this with the general AA from 2010 BRFSS data.

To examine the influential factors associated with HRQOL-4 including English proficiency, perceived racial discrimination, smoking, alcohol use, and sociodemographics.

Background

Quality of life (QOL) represents individuals’ subjective perception of multidimensional aspects of life including physical, psychological, social and spiritual aspects.

HRQOL represents the physical and mental health domain of QOL.

Centers for Disease Control and Prevention (CDC) has been measuring HRQOL to capture people’s overall perceptions about their health; HRQOL has …

Notching Early Repolarization Pattern In Inferior Leads Increases Risk Of Ventricular Tachyarrhythmias In Patients With Acute Myocardial Infarction: A Meta-Analysis., Zhiwei Zhang, Konstantinos P Letsas, Yajuan Yang, Panagiotis Korantzopoulos, Guangping Li, Gan-Xin Yan, Tong Liu

Department of Medicine Faculty Papers

The aim of this of this meta-analysis was to examine the potential association between certain early repolarization (ER) characteristics and ventricular tachyarrhythmias (VTAs) in patients with acute myocardial infarction (AMI). We searched PubMed, Embase and Web of Science databases for records published until December 2014. Of the 658 initially identified records, 7 studies with a total of 1,565 patients (299 with ER and 1,266 without ER) were finally analyzed. Overall, patients with ER displayed a higher risk of VTAs following AMI compared to patients without ER [odds ratio (OR): 3.75, 95% CI: 2.62-5.37, p < 0.00001]. Subgroup analyses showed that the diagnosis of ER prior to AMI onset is a better predictor of VTAs (OR: 5.70, p < 0.00001) compared to those diagnosed after AMI onset (OR: 2.60, p = 0.00001). Remarkably, a notching morphology was a significant predictor of VTAs compared to slurring morphology (OR: 3.85, p = 0.002). Finally, an inferior ER location (OR: 8.85, p < 0.00001) was significantly associated with increased risk of VTAs in AMI patients. In conclusion, our meta-analysis suggests that ER pattern is associated with greater risk of VTAs in patients with AMI. A notched ER pattern located in inferior leads confers the highest risk for VTAs in AMI.

Right Ventricular Dysfunction After Resuscitation Predicts Poor Outcomes In Cardiac Arrest Patients Independent Of Left Ventricular Function., Vimal Ramjee, Anne V. Grossestreuer, Yuan Yao, Sarah M. Perman, Marion Leary, James N. Kirkpatrick, Paul R. Forfia, Daniel M. Kolansky, Benjamin S. Abella, David F. Gaieski

Department of Emergency Medicine Faculty Papers

OBJECTIVE: Determination of clinical outcomes following resuscitation from cardiac arrest remains elusive in the immediate post-arrest period. Echocardiographic assessment shortly after resuscitation has largely focused on left ventricular (LV) function. We aimed to determine whether post-arrest right ventricular (RV) dysfunction predicts worse survival and poor neurologic outcome in cardiac arrest patients, independent of LV dysfunction.

METHODS: A single-center, retrospective cohort study at a tertiary care university hospital participating in the Penn Alliance for Therapeutic Hypothermia (PATH) Registry between 2000 and 2012.

PATIENTS: 291 in- and out-of-hospital adult cardiac arrest patients at the University of Pennsylvania who had return of spontaneous …

Repression Of Esophageal Neoplasia And Inflammatory Signaling By Anti-Mir-31 Delivery In Vivo., Cristian Taccioli, Michela Garofalo, Hongping Chen, Yubao Jiang, Guidantonio Malagoli Tagliazucchi, Gianpiero Di Leva, Hansjuerg Alder, Paolo Fadda, Justin Middleton, Karl J. Smalley, Tommaso Selmi, Srivatsava Naidu, John L. Farber, Carlo M. Croce, Louise Fong

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC, the mechanism whereby Zn regulates miR-31 expression to promote ESCC is examined.

METHODS: To inhibit in vivo esophageal miR-31 overexpression in Zn-deficient rats (n = 12-20 per group), locked nucleic acid-modified anti-miR-31 oligonucleotides were administered over five weeks. miR-31 expression was determined by northern blotting, quantitative polymerase chain reaction, and in situ hybridization. Physiological miR-31 targets were identified by microarray analysis and verified by luciferase reporter …

High Prevalence Of Obesity And Female Gender Among Patients With Concomitant Tibialis Posterior Tendonitis And Plantar Fasciitis., Christopher W. Reb, Faith A. Schick, Homyar N. Karanjia, Joseph N. Daniel

Rothman Institute Papers

UNLABELLED: The link between increased body weight and hindfoot complaints is largely based on correlation to single foot pathology. We retrospectively reviewed 6879 patients with tibialis posterior tendonitis (TPT), plantar fasciitis (PF), or both. Among patients with either TPT or PF, 1 in 11 (9%) had both. We then compared age, gender, and body mass index among these groups. Patients with both diagnoses were neither statistically older nor more obese than patients with single diagnoses. However, they were statistically more female. Given the overall high prevalence of obesity in the study population, we feel these data support the link between …

Effect Of Mycophenolate Mofetil On The White Blood Cell Count And The Frequency Of Infection In Systemic Lupus Erythematosus., Ananta Subedi, Laurence S. Magder, Michelle Petri

Department of Medicine Faculty Papers

Leukopenia is a common manifestation of SLE. Addition of immunosuppressive therapy in a SLE patient who is already leukopenic is a clinical concern. It could worsen leukopenia, increase the risk of infection, or both. The aim of this study was to analyze the immediate effect of mycophenolate mofetil on the white blood cell count and the rate of infection in SLE patients. Two hundred and forty-four patients within the Hopkins Lupus Cohort who were newly started on mycophenolate mofetil were included in the study. The white blood cell count and interval infection history on the day mycophenolate mofetil was started …

Stella Jedrziewski Wawrynovic, Genevieve Jedrziewski Williams, Kelsey Duinkerken

Jefferson Nursing Oral Histories

This oral history was completed with Genevieve (Jenny) Williams about her older sister Stella Jedrziewski Wawrynovic, a 1940 graduate of Jefferson's Nursing Training School.

Stella Jedrziewski Wawrynovic was born in Osceola Mills, Pennsylvania to Polish immigrants. Her parents championed the importance of education for all of their children, and so when the oldest daughter Stella graduated from high school in 1936 she moved to Philadelphia to pursue a nursing degree at Jefferson's Nursing School. She began her career at Jefferson before joining the Army during WWII to work as a nurse. After the war she returned to Jefferson, where she …

Nurses Alumni Association Bulletin, Fall 2015, Susan Albrecht Curcio, Aileen Ishuin Macmillan, Ruth Huff Iuliano

Nursing Alumni Bulletins

2014 – 2015 Meeting Dates Calendar

2015 Annual Luncheon & Meeting Notice

Officers, Committee Chairs, Satellite and Volunteers

2015 President’s Message

Treasurer’s Financial Report

Resume of Minutes

Alumni Office News

Committee Reports

• Social
• Relief Trust Fund
• Satellite–Harrisburg Satellite Area
• Scholarship
• Nominating
• Bulletin
• By Laws

Jefferson Alumni Relations

125th Anniversary

Annual Giving Contributors

Janet C. Hindson Award

• Janet C. Hindson 2015 Award winner

News About Our Graduates

History of the Cap

Pearls of Wisdom

Happy Birthday – To Be 80 or More

Annual Luncheon

• 50th Anniversary Class List for 1965 – 2015 Luncheon
• 2015 Luncheon Attendees
• 50th Anniversary Class List for …

Scitech News Volume 69, No. 4

Sci-Tech News

Table of Contents:

Columns and Reports

From the Editor 5

SciTech News Call for Articles 5

Division News

Science-Technology Division 6

Preliminary Results from SciTech Survey 15

Chemistry Division 18

Membership Survey Report 19

Appendix: Summary of DCHE 2015 Membership Survey Result 20

Engineering Division 42

Engineering Division Executive Board Election Results 44

Aerospace Section of the Engineering Division 45

Call for Nominations & Applications

Engineering Division: First call - 2016 award nominations & applications 43

Reviews Sci-Tech Book News Reviews 46

Advertisements Annual Reviews 3

CRC Press 4

Perceived Barriers To Infection Prevention And Control For Nursing Home Certified Nursing Assistants: A Qualitative Study., Jasmine Travers, Carolyn T A Herzig, Monika Pogorzelska-Maziarz, Eileen Carter, Catherine C Cohen, Patricia K Semeraro, Ragnhildur I Bjarnadottir, Patricia W Stone

College of Nursing Faculty Papers & Presentations

Healthcare-associated infections, while preventable, result in increased morbidity and mortality in nursing home (NH) residents. Frontline personnel, such as certified nursing assistants (CNAs), are crucial to successful implementation of infection prevention and control (IPC) practices. The purpose of this study was to explore barriers to implementing and maintaining IPC practices for NH CNAs as well as to describe strategies used to overcome these barriers. We conducted a multi-site qualitative study of NH personnel important to infection control. Audio-recorded interviews were transcribed verbatim and transcripts were analyzed using conventional content analysis. Five key themes emerged as perceived barriers to effective IPC …

Reach For The Stars: Improving Upper Extremity Function After Spinal Cord Injury, Carlisle Bland, Ots, Molly Bucciero, Ots, Shelby Hankins, Ots, Blair Krevitz, Ots, Nicole Matyas, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1.) Describe how cervical spinal cord injury affects UE functioning necessary for activities of daily living.

2.) Describe occupational therapy interventions used to increase UE functioning in cervical SCI.

3.) Discuss how current evidence supports implementing occupational therapy interventions into clinical practice for individuals with cervical SCI, in order to maximize independence in activities of daily living.

PICO: What is the evidence supporting occupational therapy interventions to increase upper extremity function in order to improve ADL performance following Cervical Spinal Cord Injury?

Presentation: 42 minutes

Early Mobilization In The Intensive Care Unit (Icu): A Systematic Review, Lara Belasco, Ots, Shannon Dixon, Ots, Nina Pesce, Ots, Jennifer Wong, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Learning Objectives:

At the conclusion of the session, the learner will be able to:

1. Explain early mobilization techniques in the Intensive Care Unit (ICU)

2. Identify the role of occupational therapy in the ICU

3. Discuss the implications of early mobilization interventions for adults in the ICU

Clinical Question:

What are the effects of early mobilization on ADL performance for adults in the ICU?

Presentation: 42 minutes

A World Of Opportunities: Community Reintegration For Individuals With Brain Injury, Francine Gebbia, Ots, Amy Miller, Ots, Marianella Sanchez, Ots, Erica Serviolo, Ots, David Turoff, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

● Define community reintegration within the scope of occupational therapy

● Explain the importance of community reintegration for adults with a brain injury

● Discuss the effectiveness of occupational therapy interventions used to promote community reintegration

for adults with a brain injury

PICO:

What is the effectiveness of occupational therapy interventions in community reintegration for individuals with brain injury?

Presentation: 53 minutes

Making It Work: Individuals With Autism Spectrum Disorder And Adaptations For Successful Employment, Kelsey Curran, Julia Huntington, Amanda Siefert, Kristina Slog, Meagan Stromer, Kristina Toussaint

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1. Discuss barriers to achieving successful postsecondary employment outcomes for individuals with Autism Spectrum Disorder.

2. Identify and describe evidence for adaptations that support individuals in post-secondary employment.

3. Interpret the clinical implications of the presented findings for occupational therapists, clinicians, educators, and researchers.

PICO: For individuals with Autism Spectrum Disorder (ASD), what adaptations effectively support postsecondary employment and/or job specific skills?

Methods:

• Developed a PICO question, identified databases, search terms, and inclusion and exclusion criteria

• Systematically searched databases using Scopus, ERIC (Ovid), & CINAHL and screened articles by title, abstract and full-text

•23 final …

Adiporon, The First Orally Active Adiponectin Receptor Activator, Attenuates Postischemic Myocardial Apoptosis Through Both Ampk-Mediated And Ampk-Independent Signalings., Yanqing Zhang, Jianli Zhao, Rui Li, Wayne Bond Lau, Yue-Xing Yuan, Bin Liang, Rong Li, Er-He Gao, Walter J. Koch, Xin-Liang Ma, Ya-Jing Wang

Department of Emergency Medicine Faculty Papers

Adiponectin (APN) is a cardioprotective molecule. Its reduction in diabetes exacerbates myocardial ischemia/reperfusion (MI/R) injury. Although APN administration in animals attenuates MI/R injury, multiple factors limit its clinical application. The current study investigated whether AdipoRon, the first orally active molecule that binds APN receptors, may protect the heart against MI/R injury, and if so, to delineate the involved mechanisms. Wild-type (WT), APN knockout (APN-KO), and cardiomyocyte specific-AMPK dominant negative (AMPK-DN) mice were treated with vehicle or AdipoRon (50 mg/kg, 10 min prior to MI) and subjected to MI/R (30 min/3-24 h). Compared with vehicle, oral administration of AdipoRon to WT …

Annual Report Fall 2014-Summer 2015: The Design, Implementation, & Assessment Of Nexus Learning Hubs, Jeffrey Ashley, Susan Frosten, Marion Roydhouse, Sally Dankner, Shannon Gahagan

Annual Reports & Administrative Documents

Executive Summary

Literature suggests that active and collaborative pedagogies, as compared to traditional lecturing, may enhance student engagement, motivation, retention, learning, and achievement. While Philadelphia University’s faculty members have embraced these Nexus Learning pedagogies that facilitate active and collaborative learning, the built environment of our traditional classrooms, and their associated technologies, have often limited the effectiveness. Philadelphia University began an initiative aiming to radically transform existing traditional learning spaces into intentionally designed learning environments that aim to minimize the physical and technological limitations of some of our traditional classrooms and maximize the beneficial evidence-based approaches of active, collaborative, real world …

Jefferson Digital Commons Quarterly Report: April-June 2015, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Jefferson Digital Commons Reports

This quarterly report includes:

• 10,000th Asset
• Pennsylvania Research Commons
• Faculty Day presentations
• Variety of new assets in the JDC
• Inside Out literary journal
• What people are saying about the JDC

Strategies For Searching The Internet For Orthopedic Surgeons: Tips And Tricks, Fatih Küçükdurmaz, Md, Terry Whipple, Md, Murat Bozkurt, Md, Daniel G. Kipnis, Msi

Academic Commons and Scott Memorial Library Staff Papers and Presentations

Internet provides access to large amounts of information quickly, provides a flexible learning platform, and is easily accessible from anywhere, especially with new technologies. Web-based search engines and bibliographic databases, have already become part of a doctor's everyday life. However, even well-published researchers often fail to appreciate the background knowledge required to conduct a good literature search on the internet. Using the right techniques can improve the ability to search for relevant information This chapter briefly outlines the internet as an information resources such as Google, Google Scholar, PubMed, Cochrane for orthopedic surgeons. Also the subsequent sections of the chapter …

Understanding Infection Prevention And Control In Nursing Homes: A Qualitative Study., Patricia W. Stone, Carolyn T.A. Herzig, Monika Pogorzelska-Maziarz, Eileen Carter, Ragnhildur I. Bjarnadottir, Patricia K. Semeraro, Catherine C. Cohen, Jasmine Travers, Steven Schweon

College of Nursing Faculty Papers & Presentations

Infections have been identified as a priority issue in nursing homes (NHs). We conducted a qualitative study purposively sampling 10 NHs across the country where 6-8 employees were recruited (N = 73). Semi-structured, open-ended guides were used to conduct in-depth interviews. Data were audiotaped, transcribed and a content analysis was performed. Five themes emerged: 'Residents' Needs', 'Roles and Training' 'Using Infection Data,' 'External Resources' and 'Focus on Hand Hygiene.' Infection prevention was a priority in the NHs visited. While all sites had hand hygiene programs, other recommended areas were not a focus and many sites were not aware of available …

Treatment For Inclusion Body Myositis, Michael R. Rose, Katherine Jones, Kevin Leong, Maggie C. Walter, James Miller, Marinos Dalakas, Ruth Brassington, Robert Griggs

Department of Neurology Faculty Papers

Background Inclusion body myositis (IBM) is a late-onset inflammatory muscle disease (myopathy) associated with progressive proximal and distal limb muscle atrophy and weakness. Treatment options have attempted to target inflammatory and atrophic features of this condition (for example with immunosuppressive and immunomodulating drugs, anabolic steroids, and antioxidant treatments), although as yet there is no known effective treatment for reversing or minimising the progression of inclusion body myositis. In this review we have considered the benefits, adverse effects, and costs of treatment in targeting cardinal effects of the condition, namely muscle atrophy, weakness, and functional impairment. Objectives To assess the effects …

An Adapted Mindfulness-Based Stress Reduction Program For Elders In A Continuing Care Retirement Community: Quantitative And Qualitative Results From A Pilot Randomized Controlled Trial., Aleeze Sattar Moss, Phd, Diane K. Reibel, Jeffrey M Greeson, Anjali Thapar, Rebecca Bubb, Jacqueline Salmon, Andrew B. Newberg, Md

Marcus Institute of Integrative Health Faculty Papers

The purpose of this study was to test the feasibility and effectiveness of an adapted 8-week Mindfulness-Based Stress Reduction (MBSR) program for elders in a continuing care community. This mixed-methods study used both quantitative and qualitative measures. A randomized waitlist control design was used for the quantitative aspect of the study. Thirty-nine elderly were randomized to MBSR (n = 20) or a waitlist control group (n = 19), mean age was 82 years. Both groups completed pre-post measures of health-related quality of life, acceptance and psychological flexibility, facets of mindfulness, self-compassion, and psychological distress. A subset of MBSR participants completed …

Depression Among Asian-American Adults In The Community: Systematic Review And Meta-Analysis., Hee Jun Kim, Eunmi Park, Carla L Storr, Katherine Tran, Hee-Soon Juon

Department of Medical Oncology Faculty Papers

OBJECTIVES: In this systematic review, we provide an overview of the literature on depression among Asian-Americans and explore the possible variations in depression prevalence estimates by methodological and demographic factors.

METHODS: Six databases were used to identify studies reporting a prevalence estimate for depression in Asian-American adults in non-clinical settings. Meta-analysis was used to calculate pooled estimates of rates of depression by assessment type. Statistical heterogeneity was assessed for subgroup analyses by gender, age, ethnicity, and other participant characteristics.

RESULTS: A total of 58 studies met the review criteria (n = 21.731 Asian-American adults). Heterogeneity across the studies was considerably …

2015 Commencement For Sidney Kimmel Medical College, Jefferson Graduate School Of Biomedical Sciences, And Jefferson School Of Population Health

Sidney Kimmel Medical College Commencements

No abstract provided.

2015 Commencement For Sidney Kimmel Medical College, Jefferson Graduate School Of Biomedical Sciences, And Jefferson School Of Population Health

Jefferson College of Biomedical Sciences Commencement

No abstract provided.

2015 Commencement For Sidney Kimmel Medical College, Jefferson Graduate School Of Biomedical Sciences, And Jefferson School Of Population Health

Jefferson College of Population Health Commencement

No abstract provided.

2015 Commencement For Jefferson School Of Health Professions, Jefferson School Of Pharmacy, And Jefferson School Of Nursing

Jefferson College of Health Professions and Jefferson College of Pharmacy

No abstract provided.