Digital Commons Network^™

Tau Phosphorylation At Alzheimer's Disease-Related Ser356 Contributes To Tau Stabilization When Par-1/Mark Activity Is Elevated., Kanae Ando, Mikiko Oka, Yosuke Ohtake, Motoki Hayashishita, Sawako Shimizu, Shin-Ichi Hisanaga, Koichi M. Iijima

Department of Neuroscience Faculty Papers

Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer's disease (AD). AD-related phosphorylation of two tau residues, Ser262 and Ser356, by PAR-1/MARK stabilizes tau in the initial phase of mismetabolism, leading to subsequent phosphorylation events, accumulation, and toxicity. However, the relative contribution of phosphorylation at each of these sites to tau stabilization has not yet been elucidated. In a Drosophila model of human tau toxicity, we found that tau was phosphorylated at Ser262, but not at Ser356, and that blocking Ser262 phosphorylation decreased total tau levels. By contrast, when PAR-1 was co-overexpressed with tau, …

Neurogenic Fever After Acute Traumatic Spinal Cord Injury: A Qualitative Systematic Review., Katherine E. Savage, Christina V. Oleson, Gregory D. Schroeder, Gursukhman S Sidhu, Alex R. Vaccaro

Rothman Institute Papers

STUDY DESIGN: Systematic review.

OBJECTIVE: To determine the incidence, pathogenesis, and clinical outcomes related to neurogenic fevers following traumatic spinal cord injury (SCI).

METHODS: A systematic review of the literature was performed on thermodysregulation secondary to acute traumatic SCI in adult patients. A literature search was performed using PubMed (MEDLINE), Cochrane Central Register of Controlled Trials, and Scopus. Using strict inclusion and exclusion criteria, seven relevant articles were obtained.

RESULTS: The incidence of fever of all origins (both known and unknown) after SCI ranged from 22.5 to 71.7% with a mean incidence of 50.6% and a median incidence of 50.0%. …

Chemical Modification Of Extracellular Matrix By Cold Atmospheric Plasma-Generated Reactive Species Affects Chondrogenesis And Bone Formation., Peter Eisenhauer, Natalie Chernets, You Song, Danil Dobrynin, Nancy Pleshko, Marla J Steinbeck, Theresa A. Freeman

Department of Orthopaedic Surgery Faculty Papers

The goal of this study was to investigate whether cold plasma generated by dielectric barrier discharge (DBD) modifies extracellular matrices (ECM) to influence chondrogenesis and endochondral ossification. Replacement of cartilage by bone during endochondral ossification is essential in fetal skeletal development, bone growth and fracture healing. Regulation of this process by the ECM occurs through matrix remodelling, involving a variety of cell attachment molecules and growth factors, which influence cell morphology and protein expression. The commercially available ECM, Matrigel, was treated with microsecond or nanosecond pulsed (μsp or nsp, respectively) DBD frequencies conditions at the equivalent frequencies (1 kHz) or …

Pain Management After Outpatient Anterior Cruciate Ligament Reconstruction: A Systematic Review Of Randomized Controlled Trials., Eric S. Secrist, Kevin B. Freedman, Michael G. Ciccotti, Donald W. Mazur, Sommer Hammoud

Rothman Institute Papers

BACKGROUND: Effective pain management after anterior cruciate ligament (ACL) reconstruction improves patient satisfaction and function.

PURPOSE: To collect and evaluate the available evidence from randomized controlled trials (RCTs) on pain control after ACL reconstruction.

STUDY DESIGN: Systematic review.

METHODS: A systematic literature review was performed using PubMed, Medline, Google Scholar, UpToDate, Cochrane Reviews, CINAHL, and Scopus following PRISMA guidelines (July 2014). Only RCTs comparing a method of postoperative pain control to another method or placebo were included.

RESULTS: A total of 77 RCTs met inclusion criteria: 14 on regional nerve blocks, 21 on intra-articular injections, 4 on intramuscular/intravenous injections, 12 …

Recurrent Violent Injury: Magnitude, Risk Factors, And Opportunities For Intervention From A Statewide Analysis., Elinore Kaufman, Kristin L. Rising, Md, Ms, Douglas J. Wiebe, David J. Ebler, Marie L. Crandall, M. Kit Delgado

Department of Emergency Medicine Faculty Papers

INTRODUCTION: Although preventing recurrent violent injury is an important component of a public health approach to interpersonal violence and a common focus of violence intervention programs, the true incidence of recurrent violent injury is unknown. Prior studies have reported recurrence rates from 0.8% to 44%, and risk factors for recurrence are not well established.

METHODS: We used a statewide, all-payer database to perform a retrospective cohort study of emergency department visits for injury due to interpersonal violence in Florida, following up patients injured in 2010 for recurrence through 2012. We assessed risk factors for recurrence with multivariable logistic regression and …

Polypharmacy And Potentially Inappropriate Medication Use In Geriatric Oncology., Manvi Sharma, Kah Poh Loh, Ginah Nightingale Pharmd, Bcop, Supriya G. Mohile, Holly M. Holmes

College of Pharmacy Faculty Papers

Polypharmacy is a highly prevalent problem in older persons, and is challenging to assess and improve due to variations in definitions of the problem and the heterogeneous methods of medication review and reduction. The purpose of this review is to summarize evidence regarding the prevalence and impact of polypharmacy in geriatric oncology patients and to provide recommendations for assessment and management. Polypharmacy has somewhat variably been incorporated into geriatric assessment studies in geriatric oncology, and polypharmacy has not been consistently evaluated as a predictor of negative outcomes in patients with cancer. Once screened, interventions for polypharmacy are even more uncertain. …

Therapeutic Interventions For The Treatment Of Infants Exposed To Drugs And Alcohol In Utero, Faigie Bier, Ots, Elizabeth Fenn, Ots, Angela Kochobay, Ots, Katie Moran, Ots, Kavita Naik, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus (Complete): Children and Youth

Learning Objectives (Provide 3 learning objectives):

At the conclusion of the session, the learner will be able to:

1. Identify areas of occupational performance that are affected when an infant is born with Neonatal Abstinence Syndrome or Fetal Alcohol Spectrum Disorder.
2. Recognize the importance of therapeutic interventions in promoting healthy development and participation of infants within the scope of practice for occupational therapy.
3. Apply evidence-based occupational therapy interventions for infants with Neonatal Abstinence Syndrome (NAS) or Fetal Alcohol Spectrum Disorders (FASD).

Abstract:

In the United States, approximately 0.2-1.5 per 1,000 infants are …

Losing A Limb, Regaining Independence: A Systematic Review Of Occupational Therapy Interventions For Lower Extremity Amputations, Davis Berzins, Ots, Jennifer Cohen, Ots, Jamie A. Frank, Ots, Gabrielle Kirk, Ots, Jennifer Mitchell, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus:

Rehab, Disability & Participation

Learning Objectives:

1. Describe lower extremity residual limb care interventions within the scope of occupational therapy
2. Explain the prevalence of individuals who sustain a lower extremity amputation and understand the impact on the U.S. health-care system
3. Identify lower extremity residual limb care interventions to maximize occupational performance

Abstract:

The purpose of this presentation is to report findings of a systematic review regarding residual limb care interventions supporting increased occupational performance in adults post lower extremity amputation. A systematic review was completed utilizing PubMed, CINHAL, and OTseeker. Inclusion criteria included articles with a sample of adults …

Can I Have Your Attention? (And Keep It): Interventions To Improve Executive Function Skills In Children Post-Traumatic Brain Injury, Brianna Clee, Ots, Brianna Fecondo, Ots, Sara Johnson, Ots, Catherine Misczak, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Children and Youth

Secondary Focus: Rehab, Disability, & Participation

Learning Objectives:

*Objective 1: Identify and recognize the clinical need of the pediatric traumatic brain injury population in regards to OT practice.

*Objective 2: Interpret presented findings to identify 2-3 of the most effective interventions for desired outcomes for this population.

*Objective 3: Differentiate opportunities and barriers to implementing effective executive functioning interventions in current occupational therapy practice.

Abstract:

Traumatic brain injuries are a frequent source of disability within the pediatric population with estimates of 500:100,00 children in America experiencing an injury each year (Anderson et al., 2012). …

Occupational Therapy Interventions For Activities Of Daily Living In Adults With Osteoarthritis, Amanda Gilroy, Ots, Anna Guthrie, Ots, Tierney Guido, Ots, Maura Iacobucci, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Productive Aging

Learning Objectives:

At the end of this presentation, participants will be able to:

1. Describe the clinical presentation of osteoarthritis and three ways it impacts Activities of Daily Living (ADL) performance
2. Recognize the value of an Occupational Therapy intervention in addition to surgical and pharmacological interventions for osteoarthritis
3. Identify at least three current evidence based practice interventions for improving ADL performance for people with osteoarthritis

Abstract:

Currently, 30.8 million Americans have diagnoses of osteoarthritis (OA) and the number of individuals with arthritis is projected to increase to 78 million by 2040 (CDC, 2016). Health care costs for …

Fall Prevention Interventions For Community-Dwelling Older Adults, Monica Heacock, Ots, Erin Kelly, Ots, June Park, Ots, Alex Muscella, Ots, Tony Thierolf, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Productive Aging

Learning Objectives:

At the conclusion of the session, the learner will be able to: 1. Recognize the impact of falls on community-dwelling older adults

2. Describe ways to include fall prevention interventions into current clinical practice

3. Discuss benefits of preventative interventions in regards to current healthcare trends

Abstract: According to the Centers for Disease Control and Prevention (CDC), older adults (65+ years) are the largest growing population in the United States which comprises 14.5% of the total population (CDC, 2015). This population is estimated to almost double by 2030 to approximately 71 million Americans over …

Occupational Therapy In Preventative Care: Promoting Cardiovascular Health In Underserved Women, David Goldstein, Ots, Rachel Marlow, Ots, Katherine Nelson, Ots, Megan Smith, Ots, Phoi Truong, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus:

☝ Health & Wellness

Level of session: intermediate, mixed audience

Learning Objectives:

By the conclusion of this presentation, participants will:

Describe how health disparities affect underserved women

Identify evidence supporting the inclusion of occupational therapy in preventative care practice

Discuss occupational therapy’s role in preventative care as it relates to cardiovascular health and wellness

Abstract:

Heart disease causes one in three deaths each year in women (AHA, 2012). Increasing healthcare costs disproportionately affect women with low incomes and those from diverse backgrounds (CHUW, 2012). For underserved women, lack of insurance, education and variations in culture may compromise …

You’Ve Got Time: Occupational Therapy’S Role In The Juvenile Justice System, Monica Dasgupta, Ots, Jenna Hannan, Ots, Helena Riekena, Ots, Samantha Susson, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Children and Youth

Learning Objectives:

1. State one economic and two population health implications of juvenile incarceration in the United States.
2. Identify two occupation-based interventions implemented in the juvenile justice system.
3. Recognize two areas of opportunity for occupational therapy intervention in the juvenile justice system to promote occupational justice and reduce recidivism.

Abstract:

This is an introductory level presentation for occupational therapists (OTs), occupational therapy assistants, and students intended to provide insight to areas of opportunity for OT intervention to reduce recidivism in the juvenile justice system. A systematic review of the literature was conducted to answer the …

The 2015 American-British-Canadian Traveling Fellows Report., Alpesh A. Patel, Robert H. Brophy, Rajiv Gandhi, Hue H. Luu, Kishore Mulpuri, Suken A Shah, Sanjeev Kakar

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

Mitochondrial Akt Regulation Of Hypoxic Tumor Reprogramming., Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, Dario C. Altieri

Department of Cancer Biology Faculty Papers

Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms are not completely understood. Using a phosphoproteomics screen, we now show that active Akt accumulates in the mitochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex. In turn, this pathway switches tumor metabolism toward glycolysis, antagonizes apoptosis and autophagy, dampens oxidative stress, and maintains tumor cell proliferation in the face of severe hypoxia. Mitochondrial Akt-PDK1 signaling correlates with unfavorable prognostic markers and shorter survival in glioma patients and may provide an "actionable" therapeutic target in cancer.

The Core Of Care Management: The Role Of Authentic Relationships In Caring For Patients With Frequent Hospitalizations., Charlotte Grinberg, Margaret Hawthorne, Marianna Lanoue, Jeffrey Brenner, Dawn B Mautner

Department of Family & Community Medicine Faculty Papers

In the movement to improve the health of patients with multiple chronic conditions and vulnerabilities, while reducing the need for hospitalizations, care management programs have garnered wide attention and support. The qualitative data presented in this paper sheds new light on key components of successful chronic care management programs. By going beyond a task- and temporal-based framework, this analysis identifies and defines the importance of "authentic healing relationships" in driving individual and systemic change. Drawing on the voices of 30 former clients of the Camden Coalition of Healthcare Providers, the investigators use qualitative methods to identify and elaborate the core …

Leadership In Design And Construction Education And Practice, Michael Asada, Al Bradley, Guy Thigpen, John Pourdehnad, Phd, Tom Guggino, Dominick Volini, Phd, Kimberlee Douglas, Barbara Klinkhammer, Larry Starr, Phd

School of Continuing and Professional Studies Faculty Papers

It has been conveyed that inspiration and creativity are the greatest strengths of architects. Those who possess them often demonstrate innovation and ability to transform diverse, often contradictory, information into a cohesive design. Yet, having architectural and design talent may suggest to some that they also have a broader skill set. Among the competencies that do not necessarily co-exist with inspiration and creativity are those associated with managing or leading a complex project or organization.

Leadership and many of the administrative and project management competencies needed to operate in the modern complex environment of the Architecture profession are largely absent …

Statins And Exercise Training Response In Heart Failure Patients: Insights From Hf-Action., Jacob P. Kelly, Allison Dunning, Phillip J. Schulte, Mona Fiuzat, Eric S. Leifer, Jerome L. Fleg, Lawton S. Cooper, Steven J. Keteyian, Dalane W. Kitzman, Ileana L. Pina, William E. Kraus, David J. Whellan, Christopher M. O'Connor, Robert J. Mentz

Division of Cardiology Faculty Papers

OBJECTIVES: The aim of this study was to assess for a treatment interaction between statin use and exercise training (ET) response.

BACKGROUND: Recent data suggest that statins may attenuate ET response, but limited data exist in patients with heart failure (HF).

METHODS: HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) was a randomized trial of 2,331 patients with chronic HF with ejection fraction ≤35% who were randomized to usual care with or without ET. We evaluated whether there was a treatment interaction between statins and ET response for the change in quality of life and aerobic capacity …

Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Supplemented Through 2015, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21^st century. In short, yes. While Index …

Bibliography Of Secondary Sources On The History Of Dermatology, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21^st century. In short, yes. While Index …

Bibliography Of Secondary Sources On The History Of Dermatology Iii. Books, Monographs, And Chapters In English Supplemented Through 2015, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp (Uk, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21^st century. In short, yes. While Index …

Annual Report 2015-2016, Jeffrey Ashley

Annual Reports & Administrative Documents

No abstract provided.

Barriers And Facilitators To Cervical Cancer Screening Among Iraqi Refugees Resettled In Philadelphia: A Qualitative Analysis Of Patient And Provider Perceptions, Colleen Payton, Mph, Ches, Laura Parente, Md, Dalea Al-Hawarri, Md, Philip Manasseh, Mph, Kevin Scott, Md, Marc Altshuler, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Oral presentation at the 6^th Annual North American Refugee Health Conference, Niagara Falls, New York.

Research Questions:

1. What is the prevalence of cervical cancer and cervical cancer screening among recently resettled refugees seen at Jefferson's Center for Refugee Health?

2. Are patient-and provider-identified barriers to cervical cancer screening at CRH consistent with those identified in previous research efforts?

3. What are patient-and provider identified facilitators to cervical cancer screening for Iraqi refugee women?

Hepatocellular Carcinoma After Locoregional Therapy: Magnetic Resonance Imaging Findings In Falsely Negative Exams., David Becker-Weidman, Jesse M. Civan, Sandeep P. Deshmukh, Christopher G. Roth, Steven K. Herrine, Laurence Parker, Donald G. Mitchell

Division of Gastroenterology and Hepatology Faculty Papers

AIM: To elucidate causes for false negative magnetic resonance imaging (MRI) exams by identifying imaging characteristics that predict viable hepatocellular carcinoma (HCC) in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.

METHODS: This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy. All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrent tumor. Retrospectively, 2 …

Illness Cognitions And Coping Self-Efficacy In Depression Among Persons With Low Vision., Bonnie A Sturrock, Jing Xie, Edith E Holloway, Mark Hegel, Robin J. Casten, David Mellor, Eva Fenwick, Gwyneth Rees

Department of Psychiatry and Human Behavior Faculty Papers

PURPOSE: To investigate the mediating role of coping self-efficacy (CSE) between two types of illness cognitions (i.e., acceptance and helplessness) and depressive symptoms in persons with low vision.

METHODS: This was a single-group, cross-sectional study. Patients with visual acuity < 6/12 in the better eye and at least minimal depressive symptoms (≥5 on the Patient Health Questionnaire-9 [PHQ-9]) were recruited from vision rehabilitation services and participated in telephone-administered structured interviews at one time point. Measures were the PHQ-9, CSE Scale, and Illness Cognition Questionnaire. Structural equation modeling (SEM) devised the causal flow of illness cognitions and their observed indirect effects on depressive symptoms via the CSE mediators: problem focused, emotion focused, and social support.

RESULTS: The study comprised 163 patients (mean age 62 years; 61% female), most with age-related macular degeneration (26%) and moderate vision impairment (44%, <6/18-6/60). Structural equation modeling indices indicated a perfect fit (χ2 < 0.001, P = 1.00), accounting for 55% of the variance in depressive symptoms. Lower levels of acceptance and higher levels of helplessness illness cognitions were associated with lower self-efficacy in problem-focused coping (β = 0.38, P < 0.001, β = -0.28, P < 0.01, respectively), which in turn was associated with greater depressive symptom severity (β = -0.54, P < 0.001).

CONCLUSIONS: Lack of acceptance and greater helplessness relating to low vision led to a lack of perceived capability to engage in problem-focused coping, which in turn promoted depressive symptoms. Third-wave cognitive-behavioral treatments that focus on acceptance may be …

Scitech News Volume 70, No. 2 (2016)

Sci-Tech News

Table of Contents:

Columns and Reports From the Editor 3

Division News

Science-Technology Division 4

New Members 6

Chemistry Division 7

New Members11

Engineering Division 12

Aerospace Section of the Engineering Division 17

Reviews

Sci-Tech Book News Reviews 19

Literature Review On Hospital Costs For Patients Undergoing Colectomy, Brian P.H. Chen, Scm, Hang Cheng, Martha Romney, Rn, Ms, Jd, Mph, Carine Chia-Wen Hsiao

College of Population Health Posters

Objective:

This study aims to identify the range of direct hospital costs associated with a minimally invasive or open colectomy procedure across different countries.

Poster presented at 2016 ISPOR conference in Washington DC.

Literature Review On Hospital Costs For Patients Undergoing Hysterectomy, Brian P.H. Chen, Scm, Pharmd, Hang Cheng, Martha Romney, Rn, Ms, Jd, Mph, Carine Chia-Wen Hsiao

College of Population Health Posters

Objective:

This study aims to identify the range of direct hospital costs associated with a minimally invasive or abdonimal hysterectomy procedure across different countries.

Poster presented at 2016 ISPOR conference in Washington DC.

Student Group Activity

Office of Diversity & Inclusion Initiatives Newsletter

Descriptions of the following Student Groups:

• Student National Medical Association
• JeffLGBTQ
• Jewish Student Association
• Jefferson Muslim Society
• Latino Medical Students Association
• Medical Spanish Translator Program
• Diversity Council
• Asian Pacific American Medical Students Association
• Diversity and Inclusion Student Advisory Board

Adiponectin Ameliorates The Apoptotic Effects Of Paraquat On Alveolar Type Ⅱ Cells Via Improvements In Mitochondrial Function., Yarong He, Liqun Zou, Yaxiong Zhou, Hai Hu, Rong Yao, Yaowen Jiang, Wayne Bond Lau, Tun Yuan, Wen Huang, Zhi Zeng, Yu Cao

Department of Emergency Medicine Faculty Papers

Previous studies have demonstrated that excessive reactive oxygen/nitrogen species (ROS/RNS)‑induced apoptosis is an important feature of the injury to the lung epithelium in paraquat (PQ) poisoning. However the precise mechanisms of PQ‑induced dysfunction of the mitochondria, where ROS/RNS are predominantly produced, remain to be fully elucidated. Whether globular adiponectin (gAd), a potent molecule protective to mitochondria, regulates the mitochondrial function of alveolar type II cells to reduce PQ‑induced ROS/RNS production remains to be investigated. The current study aimed to investigate the precise mechanisms of PQ poisoning in the mitochondria of alveolar type II cells, and to elucidate the role of …