Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Physical Sciences and Mathematics (7711)
- Life Sciences (5833)
- Medicine and Health Sciences (4678)
- Medical Sciences (3344)
- Computer Engineering (2852)
-
- Computer Sciences (2852)
- Electrical and Computer Engineering (2852)
- Engineering (2852)
- Animal Sciences (2532)
- Mathematics (1969)
- Chemistry (1528)
- Veterinary Medicine (1334)
- Agriculture (1249)
- Forest Sciences (1249)
- Zoology (1198)
- Botany (1048)
- Plant Sciences (1048)
- Biology (1004)
- Earth Sciences (763)
- Physics (599)
- Keyword
-
- Turkey (586)
- Taxonomy (199)
- COVID-19 (155)
- Oxidative stress (136)
- New species (125)
-
- New records (105)
- Apoptosis (96)
- Morphology (88)
- Inflammation (86)
- Children (85)
- Classification (85)
- Deep learning (85)
- Iran (85)
- Antioxidant (81)
- Machine learning (80)
- Breast cancer (79)
- New record (78)
- Phylogeny (75)
- Biodiversity (72)
- Rat (71)
- Optimization (68)
- Genetic diversity (66)
- Distribution (64)
- Mortality (64)
- Cytotoxicity (63)
- Fauna (60)
- Genetic algorithm (60)
- Cancer (58)
- Gene expression (58)
- SARS-CoV-2 (55)
- Publication Year
Articles 1081 - 1110 of 18793
Full-Text Articles in Entire DC Network
Molecular Phylogeny And Population Structure Of Eurygaster Integriceps (Hemiptera: Scutelleridae) In The Southeastern Anatolia Region Of Türkiye, Mehmet Sali̇h Özgökçe, Merve Doğaç, Hi̇lmi̇ Kara
Molecular Phylogeny And Population Structure Of Eurygaster Integriceps (Hemiptera: Scutelleridae) In The Southeastern Anatolia Region Of Türkiye, Mehmet Sali̇h Özgökçe, Merve Doğaç, Hi̇lmi̇ Kara
Turkish Journal of Zoology
The aim of this study was to determine the identity and distribution of the sunn pest Eurygaster spp. and to quantify the population density in wheat fields across Southeastern Anatolia, Türkiye. A total of 309 samples were collected from 76 fields in 54 districts across all provinces within the study region, where wheat production is intensive. A combination of morphological and molecular techniques was employed to identify the collected specimens. Morphological identification was based on male genitalia, and PCR amplification of the COI mitochondrial gene region was used for DNA barcoding. Both morphological and molecular analyses confirmed that all collected …
Protein Composition Of The Foam Nest Of Rhacophorus Reinwardtii (Schlegel, 1840) (Anura: Rhacophoridae), With Notes On Breeding Sites Characteristics And Biomedical Applications, Muhammad Asyraf Rijalullah, Nia Kurniawan, Nia Kurnianingsih
Protein Composition Of The Foam Nest Of Rhacophorus Reinwardtii (Schlegel, 1840) (Anura: Rhacophoridae), With Notes On Breeding Sites Characteristics And Biomedical Applications, Muhammad Asyraf Rijalullah, Nia Kurniawan, Nia Kurnianingsih
Turkish Journal of Zoology
Rhacophorus reinwardtii is endemic to Java Island and is currently experiencing a population decline. Therefore, the sustainability of its offspring is important to prevent species extinction. Foam nest as a biosurfactant structure plays a crucial role as egg protection through major protein components function. However, studies on the functional proteins of rhacophoridae foam nests are limited. Thus, this study aims to uncover the protein-specific components and functions of the R. reinwardtii foam nest. Additionally, the characteristics of breeding sites, including abiotic factors, were also assessed. Total protein concentration of the R. reinwardtii foam nest was determined to be 747.7 μg/mL …
Molecular Crosstalk Of Transcription Factors And Hormones In Drought Tolerance Genes In Plants, Cengi̇z Kaya
Molecular Crosstalk Of Transcription Factors And Hormones In Drought Tolerance Genes In Plants, Cengi̇z Kaya
Turkish Journal of Botany
Water deficit is a critical challenge to global agricultural productivity and food security, which is exacerbated by climate change and increasing water scarcity. To withstand drought stress, plants employ a variety of molecular strategies driven by complex regulatory networks. This review examines the central role of transcription factors (TFs) as master regulators that activate drought responsive genes, which in turn mediate key adaptive processes such as osmoregulation, antioxidative defense, and membrane stability. A distinctive aspect of this review is its focus on the dynamic interplay between TFs and hormonal signaling pathways, including abscisic acid, ethylene, salicylic acid, and jasmonic acid. …
Natural Microbial Consortium Construction Strategy From Rhizospheric Agricultural Soils To Improve Wheat (Triticum Durum Desf.) Seedling Growth, Ni̇da Arslan, Mi̇ne Gül Şeker, Özlem Akkaya, Yelda Özden Çi̇ftçi̇
Natural Microbial Consortium Construction Strategy From Rhizospheric Agricultural Soils To Improve Wheat (Triticum Durum Desf.) Seedling Growth, Ni̇da Arslan, Mi̇ne Gül Şeker, Özlem Akkaya, Yelda Özden Çi̇ftçi̇
Turkish Journal of Botany
Microbial consortia of compatible microorganisms play a key role in enhancing agricultural sustainability by optimizing nutrient uptake by promoting plant growth more effectively. This study aimed to identify local isolates with the most effective plant growth-promoting (PGP) properties and to form a consortium of isolates showing the optimal synergistic effect between plant and bacterial components to improve the growth of wheat plants. For this purpose, 48 isolates identified from 145 isolates were screened for their PGP activities. According to the results, 16S rRNA gene sequencing was performed to identify the six isolates exhibiting the most promising activity. Different consortium groups …
Taxonomic Revision Of Korean Salix Section Subviminales Based On Comparative Morphology And Complete Plastome Analysis, Young Moon Kim, Shukherdorj Baasanmunkh, Nudkhuu Nyamgerel, Won Seok Lee, Dong Chan Son, In Kyu Park, Bom Bi Jin, Hyo Sig Won, Hyeok Jae Choi
Taxonomic Revision Of Korean Salix Section Subviminales Based On Comparative Morphology And Complete Plastome Analysis, Young Moon Kim, Shukherdorj Baasanmunkh, Nudkhuu Nyamgerel, Won Seok Lee, Dong Chan Son, In Kyu Park, Bom Bi Jin, Hyo Sig Won, Hyeok Jae Choi
Turkish Journal of Botany
Salix section Subviminales, including only three species, is endemic to East Asia. In this study, we revised three species, S. gracilistyla, S. graciliglans, and S. blinii in Korea based on their plastomes and extensive morphological analyses to provide a comprehensive understanding of their taxonomic relationships. Based on our findings, we identified the morphological characteristics of S. blinii endemic to Korea, including its small size and distinct leaf shapes, which are well distinguished from both S. gracilistyla and S. graciliglans. Most of the morphological characteristics of S. gracilistyla and S. graciliglans overlapped, particularly leaf shape, floral structure, and growth habits. Next, …
A New Species From Türkiye: Erigeron Akaydinii (Asteraceae), Batikan Günal, Gürkan Semi̇z, Sultan Akyol
A New Species From Türkiye: Erigeron Akaydinii (Asteraceae), Batikan Günal, Gürkan Semi̇z, Sultan Akyol
Turkish Journal of Botany
Erigeron akaydinii Günal & Semiz sp. nov., belonging to the Trimorpha Cass. (DC) section (Asteraceae), is described as a new species from Uludağ Mountain (Bursa, Türkiye). This study examines the diagnostic traits of E. akaydinii and related species, including morphological, palynological, and molecular analyses. Notes on the ecology, distribution, and conservation status of the new species are also provided, along with a diagnostic key for relevant taxa.
Ecological Assessment Of Lentic Ecosystems In Ceyhan River Basin Using Phytoplankton Indices, Abuzer Çelekli̇, Emi̇ne Yonca Gümüş, Tolga Çeti̇n
Ecological Assessment Of Lentic Ecosystems In Ceyhan River Basin Using Phytoplankton Indices, Abuzer Çelekli̇, Emi̇ne Yonca Gümüş, Tolga Çeti̇n
Turkish Journal of Botany
Increasing exploitation of water resources has led to declining water quality in aquatic environments. Freshwater ecosystems face various environmental pressures, such as the impacts of climate change and intensifying land-use practices. This study aimed to assess the ecological preferences of phytoplankton communities and determine the ecological status (ES) of several reservoirs and lakes in Ceyhan River Basin across different seasons. A canonical correspondence analysis was conducted to understand the associations between phytoplankton assemblages and stressors in freshwater ecosystems, revealing a strong correlation of 97%. The factors that most influenced the distribution of phytoplankton species were electrical conductivity (EC), temperature, total …
Genome-Wide Association Of Gene Regions Controlling Selenium And Magnesium Accumulation In Walnuts (Juglans Regia L.), İrem Büyükalgan, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş
Genome-Wide Association Of Gene Regions Controlling Selenium And Magnesium Accumulation In Walnuts (Juglans Regia L.), İrem Büyükalgan, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş
Turkish Journal of Botany
Walnut (Juglans regia L.) is one of the most economically important species. It is of great importance to the food industry due to its nutritional value, and high content of many beneficial components such as macro and microelements. In the current study, the aim was to determine markers of single nucleotide polymorphism (SNP) associated with the gene(s) controlling the accumulation of Selenium (Se) and Magnesium (Mg) in walnuts. Se and Mg concentrations were measured in 154 genotypes of Juglans regia in 2021 and 2022. A total of 16,473 SNP markers were used for association mapping to analyze the marker-trait associations. …
A New Coralloid Arecoid Palm Root Mat From The Deccan Intertrappean Beds Of India And Its Significance, Sanchita Kumar, Robert Spicer, Mahasin Ali Khan
A New Coralloid Arecoid Palm Root Mat From The Deccan Intertrappean Beds Of India And Its Significance, Sanchita Kumar, Robert Spicer, Mahasin Ali Khan
Turkish Journal of Botany
A new fossil-species of coralloid palm root mat under the organ genus Rhizopalmoxylon is reported from the latest Maastrichtian (Late Cretaceous) to earliest Danian (Early Palaeocene) sediments (c. 66–65Ma) of the Deccan Intertrappean Beds of Madhya Pradesh, Central India. The significant anatomical attributes, specifically an exodermis comprising 2–4 layered parenchymatous cells; a 5–8 layered homogeneous outer cortex, a highly lacunate inner cortex central diffuse layer of aerenchyma with well-developed radially elongated cells arranged in 2–4 rows, and a stele consisting of radial and exarch vascular bundles with proto and metaxylem strands reveal its close resemblance to root mats of extant …
Complete Genome Analyses Of A Novel Narlivirus Identified In The Ectomycorrhizal Fungus Amanita Vidua, Ilgaz Akata, Eda Kumru, Gülce Edi̇ş, Ertuğrul Kaya, Ergi̇n Şahi̇n
Complete Genome Analyses Of A Novel Narlivirus Identified In The Ectomycorrhizal Fungus Amanita Vidua, Ilgaz Akata, Eda Kumru, Gülce Edi̇ş, Ertuğrul Kaya, Ergi̇n Şahi̇n
Turkish Journal of Botany
The widespread utilisation of deep sequencing has dramatically enhanced and revolutionised our understanding of virus diversity, particularly in complex environments such as soil and biological samples. This research explored mycovirus sequence analyses in the ectomycorrhizal fungus Amanita vidua, utilising deep sequencing alongside total double-stranded RNA (dsRNA) extractions. Our investigation unveiled a unique member of the proposed family, Narliviridae, designated as Amanita vidua narlivirus 1 (AvNV1), in an A. vidua specimen. AvNV1, classified under Amabiliviricetes, possesses a distinct genome structure and sequence attributes. T horough analyses indicated that AvNV1 exhibits sequence similarities with other mycoviruses from the proposed family Narliviridae and …
Unveiling The Physical Interaction Between Gsnor1 And Trx-H Isoforms, Anika Tabassum, Gary J. Loake
Unveiling The Physical Interaction Between Gsnor1 And Trx-H Isoforms, Anika Tabassum, Gary J. Loake
Turkish Journal of Botany
This study aims to investigate any possible interaction between two highly conserved regulators of cellular SNO levels: S-nitrosoglutathione reductase (GSNOR1) and thioredoxin (TRX). These two enzymes control global S-nitrosylation levels and thus impact the cellular redox state during immune responses. A mutant line (Δtrx1trx2sfa1) of Saccharomyces cerevisiae MaV203 strain was generated to explore this possibility rather than using a classical strain. We identified and characterized the physical interaction between GSNOR1 and Arabidopsis cytosolic h isoforms in a yeast two-hybrid screen. Out of the seven TRX isoforms, AtGSNOR1 displayed a high interaction with AtTRXh3, AtTRXh4, and AtTRXh5 (AtTRXh5>AtTRXh4 & AtTRXh3). …
Pointwise Slant Riemannian Maps From Almost Contact Metric Manifolds With Horizontal Reeb Vector Field ˆΞ, Ramazan Demi̇r, Cumali̇ Yildirim
Pointwise Slant Riemannian Maps From Almost Contact Metric Manifolds With Horizontal Reeb Vector Field ˆΞ, Ramazan Demi̇r, Cumali̇ Yildirim
Turkish Journal of Mathematics
This paper introduces the notion of pointwise slant Riemannian maps, which extend the concept of slant submanifolds, pointwise slant submanifolds, slant submersions, pointwise slant submersions, and slant Riemannian maps. These maps are defined from almost contact metric manifolds to Riemannian manifolds with horizontal Reeb vektor field . Furthermore, we present examples and investigate the fundamental properties of such maps. Also we explore the geometry of the foliations induced by pointwise slant Riemannian maps and establish decomposition theorems related to their existence.
On The Invariant Integration Of A Vector In Some Problems In Mechanics, Saad Bin Mansoor
On The Invariant Integration Of A Vector In Some Problems In Mechanics, Saad Bin Mansoor
Turkish Journal of Mathematics
Invariant integration of vectors and tensors over manifolds was introduced around fifty years ago by V.N. Folomeshkin, though the concept appears to not have attracted much attention among researchers. Although it is a sophisticated concept, the operation of the invariant integration of vectors is actually required to correctly solve some problems in mechanics. Two such problems are discussed in the present exposition, in the context of a two-dimensional Euclidean space covered by a polar coordinate system. The notion of invariant integration becomes necessary when the space is described without any reference to a Cartesian coordinate system.
On Cesàro And Abel-Poisson Means Of Hexagonal Fourier Series, Ali̇ Güven
On Cesàro And Abel-Poisson Means Of Hexagonal Fourier Series, Ali̇ Güven
Turkish Journal of Mathematics
Approximation properties of Ces`aro and Abel-Poisson means of hexagonal Fourier series are studied. The degree of approximation by these means of hexagonal Fourier series of functions, which are continuous and periodic with respect to the hexagon lattice, is estimated in terms of modulus of continuity of functions.
The Concept Of T-Basis And Vector-Valued Hardy Classes, Bilal Bilalov, Sabina Rahib Sadigova
The Concept Of T-Basis And Vector-Valued Hardy Classes, Bilal Bilalov, Sabina Rahib Sadigova
Turkish Journal of Mathematics
This paper introduces the concept of a t-basis generated by some bilinear mapping t(·;·). It is considered the vector-valued class Lp(X) := Lp(J; X), 1 ≤ p < +∞, where J = [−π, π] and X is a Banach space with the UMD property, and it is proven that the classical system of exponents {eint}n∈ℤ forms a t-basis for Lp(X), 1 < p < +∞. Using this fact, the Hardy vector classes nHp±(X), 1 < p < +∞, different from the classical ones, are defined, and an equivalent definition of these classes is given and some of their properties are studied. In addition, the concept of t-Riesz property of a system of exponentials is introduced in Lp(X), 1 < p < +∞, and it is proved that this system has the t-Riesz property. A new method is given for establishing the Plemelj–Sokhotski formulas for X-valued Cauchy type integrals when X has the UMD property. An abstract analogue of the “1/4-Kadets” theorem is obtained for …
On The Images Of N-Ellipses Under The Möbius Transformations, Ni̇hal Özgür
On The Images Of N-Ellipses Under The Möbius Transformations, Ni̇hal Özgür
Turkish Journal of Mathematics
In this paper, we examine the images of n-ellipses under the Möbius transformations (linear fractional transformations) for n ≥ 3. As a result of this investigation, we present a new and generalized version (called n-generalized Apollonius circle) of the concept of an Apollonius circle in the plane.
On Cr-Structures On The Null Tangent Bundle, Mohamed Tahar Kadaoui Abbassi, Cornelia-Livia Bejan, Khadija Boulagouaz
On Cr-Structures On The Null Tangent Bundle, Mohamed Tahar Kadaoui Abbassi, Cornelia-Livia Bejan, Khadija Boulagouaz
Turkish Journal of Mathematics
The null tangent bundle of an indefinite pseudo-Riemannian manifold is a lightlike hypersurface of the tangent bundle which inherits a CR-structure from the almost Hermitian structure defined by Oproiu on the tangent bundle. We investigate the properties of this structure in relation to the choice of the screen distribution and the geometry of the base manifold.
Discrete Dirac Equations, Bilender Paşaoğlu Allahverdiev, Hüseyi̇n Tuna
Discrete Dirac Equations, Bilender Paşaoğlu Allahverdiev, Hüseyi̇n Tuna
Turkish Journal of Mathematics
In this paper, regular discrete Dirac systems are considered. Some fundamental properties are studied concerning self-adjointness, orthogonality of eigenfunctions, and eigenfunction expansions.
Lancret-Type Results For A New Family Of Curves In Minkowski 3-Space, Héctor Guerrero Mora, Willy Sierra
Lancret-Type Results For A New Family Of Curves In Minkowski 3-Space, Héctor Guerrero Mora, Willy Sierra
Turkish Journal of Mathematics
In this article, using the concept of a Killing vector field along a curve, we extend certain results concerning a family of curves—previously studied in three-dimensional Euclidean space—to the setting of three-dimensional Minkowski space. Depending on the causal character of the curve, we derive Lancret-type results that establish the necessary and sufficient conditions for the existence of this family in three-dimensional Minkowski space. We determine the intrinsic equation of this family in three cases: (i) when the curve is nonnull with a nonnull acceleration vector, (ii) when the curve is spacelike with a null acceleration vector, and (iii) when the …
Geometry Of Conformally Flat Harmonic Nearly Trans-Sasakian Manifolds, Aligadzhi Rabadanovich Rustanov, Svetlana Vladimirovna Kharitonova
Geometry Of Conformally Flat Harmonic Nearly Trans-Sasakian Manifolds, Aligadzhi Rabadanovich Rustanov, Svetlana Vladimirovna Kharitonova
Turkish Journal of Mathematics
Conformally flat harmonic nearly trans-Sasakian manifolds are studied. In the space of adjoint G-structure, components of the Weyl tensor of the conformal curvature are calculated, identities for this tensor are found, and also some conformal invariants of harmonic nearly trans-Sasakian manifold are provided. An exhaustive description of the class W1 of such manifolds is obtained. It is proved that this class is locally equivalent to the product of a complex Euclidean space and a real line. Complete local characteristic of harmonic nearly trans-Sasakian manifolds of the class W6, which are Einstein manifolds, is obtained. Full classification of conformally flat harmonic …
Progression Of Electrophysiological Impairments In Diabetic Cardiomyopathy And Intervention Using Enicostemma Axillare, Victor Arokia Doss, Dharaniyambigai Kuberapandian
Progression Of Electrophysiological Impairments In Diabetic Cardiomyopathy And Intervention Using Enicostemma Axillare, Victor Arokia Doss, Dharaniyambigai Kuberapandian
Turkish Journal of Biology
Earlier studies widely reported advanced ventricular impairments only at the later stages of diabetic cardiomyopathy (DCM). The present study aimed to understand the duration-based early to late stages of cardiac electrophysiological impairments using electrocardiography (ECG) and intervention using Enicostema axillare subsp. littorale. The experimental rats were streptozotocin (SZ)-induced diabetic rats that were administered E. axillare formulations as follows: (1) normal; (2) SZ - 40 mg/kg, single, i.p.); (3) SZ + insulin (2 U/day) + losartan (10 mg/kg); (4) SZ + insulin + losartan + E. axillare decoction (2 mL/day); (5) SZ + E. axillare decoction; (6) SZ + E. axillare …
A Tetracycline-Inducible Split Turboid System For Specific Biotinylation And Identification Of Nuclear Proteins From Hek293t Cells, Mehmet Sarihan, Fatma Zehra Özen, Murat Kasap, Gürler Akpinar
A Tetracycline-Inducible Split Turboid System For Specific Biotinylation And Identification Of Nuclear Proteins From Hek293t Cells, Mehmet Sarihan, Fatma Zehra Özen, Murat Kasap, Gürler Akpinar
Turkish Journal of Biology
Background/aim: To overcome the limitations of conventional organelle isolation methods including low purity, low yield, sample degradation, scalability and the need for multiple centrifugation steps, an improved nuclear protein enrichment approach was developed using the modified Split TurboID biotin ligase enzyme.
Materials and methods: A construct was created in which the N-terminal domain of TurboID, fused to the FK506-binding protein (FKBP) was targeted to the nucleus. This construct was incorporated into a tetracycline-inducible gene expression vector. Similarly, the C-terminal domain of TurboID was fused to the rapamycin-binding domain of mTOR (FRB) and directed to the nucleus. This construct …
Apigenin Attenuates Ischemia–Reperfusion-Induced Pulmonary Ferroptosis And Fibrosis By Activating The Nrf2/Ho-1/Gpx4 Axis In Mice, Liang Zhang, Haojie Li, Shichen Xu, Hao Wen, Chaoxiao Yu
Apigenin Attenuates Ischemia–Reperfusion-Induced Pulmonary Ferroptosis And Fibrosis By Activating The Nrf2/Ho-1/Gpx4 Axis In Mice, Liang Zhang, Haojie Li, Shichen Xu, Hao Wen, Chaoxiao Yu
Turkish Journal of Biology
Background/aim: Acute lung injury (ALI) is a major cause of morbidity and mortality after lung ischemia-reperfusion injury (LIRI). In recent years, pulmonary ferroptosis and its associated fibrosis have been recognized as important causes of LIRI. The purpose of this study is to investigate apigenin (APG) as a potential therapeutic target for treating LIRI-induced pulmonary ferroptosis and fibrosis.
Materials and methods: A rat model of LIRI was established and the rats were randomly divided into three groups, a sham group, a LIRI group, and an APG group. The pathological changes of the lung tissue were evaluated using hematoxylin-eosin staining and …
Prooxidant Effect Of Uric Acid On Human Leukocytic Dna: An In Vitro And Ex Vivo Study, Yim Tong Savio Szeto, Vincy Sze Wing Li, Yuen Lam Pon
Prooxidant Effect Of Uric Acid On Human Leukocytic Dna: An In Vitro And Ex Vivo Study, Yim Tong Savio Szeto, Vincy Sze Wing Li, Yuen Lam Pon
Turkish Journal of Biology
Background/aim: Uric acid is a major contributor to the total antioxidant capacity of human plasma. However, this endogenous substance’s antioxidant and prooxidant properties have not yet been reported.
Conclusion: In this study, the comet assay was employed in vitro to determine the effect of uric acid on DNA damage in human lymphocytes and leukocytic DNA damage in hyperuricemia patients with and without renal failure.
Results: DNA damage in lymphocytes occurred at uric acid concentrations of ≥600 μM. Adding catalase to the uric acid solution diminished the damaging effect, indicating that hydrogen peroxide mediated the prooxidant activity. Moreover, …
Intrinsic Apoptotic Effect Of Anatolian Honeybee (Apis Mellifera Anatoliaca) Venom Promoted With Mesoporous Silica Nanocarriers, Batuhan Orman, Ayli̇n Koç, Di̇dem Şen Karaman, Ayşe Nalbantsoy
Intrinsic Apoptotic Effect Of Anatolian Honeybee (Apis Mellifera Anatoliaca) Venom Promoted With Mesoporous Silica Nanocarriers, Batuhan Orman, Ayli̇n Koç, Di̇dem Şen Karaman, Ayşe Nalbantsoy
Turkish Journal of Biology
Background/aim: The use of bee products or treatment with bees, as a complement to conventional medicine is attracting considerable attention in cancer research. Although discoveries related to the potential anticancer effects of bee venom are increasing, the unstable nature of venom biomolecules remains a limiting factor for their usage. In this study, we employed mesoporous silica nanocarriers (MSNs) to provide precise dosing and prevent carriers from biomolecule degradation thanks to the outstanding loading capacity provided by the pores, excellent chemical and biological robustness, and ability to improve bioavailability.
Materials and methods: MSNs were synthesized and physicochemical characterizations were …
Resveratrol Modulates Triosephosphate Isomerase And Mineralization In Osteosarcoma Cells: Potential Target For Novel Therapeutic Strategies, Gonca Tuna, Si̇bel Çinar Asa, Eli̇f Ertürk, Yaren Yildiz, Ferda Ari
Resveratrol Modulates Triosephosphate Isomerase And Mineralization In Osteosarcoma Cells: Potential Target For Novel Therapeutic Strategies, Gonca Tuna, Si̇bel Çinar Asa, Eli̇f Ertürk, Yaren Yildiz, Ferda Ari
Turkish Journal of Biology
Background/aim: Osteosarcoma, a primary malignant bone tumor, is challenging to treat due to its aggressive nature and limited therapies. Resveratrol (RES), a natural polyphenol, has potential anticancer properties. Hence, we investigated RES’s impact on osteosarcoma cells, focusing on triosephosphate isomerase (TPI) and related mechanisms.
Materials and methods: RES was applied to osteosarcoma (SaOS-2) and healthy fetal osteoblast (hFOB 1.19) cells for 48 h, and cell viability was measured by SRB assay. The mode of cell death was examined using Hoechst 33342/annexin V/propidium iodide. TPI and methylglyoxal (MG) enzyme levels were determined by ELISA. The effect of RES on …
N-Cadherin Mimetic Hydrogels Drive Superior Regenerative And Paracrine Responses In 3d Cultures Of Adipose-Derived Mesenchymal Stem Cells, Demet Kaçaroğlu, Alper Murat Ulaşli, Aybüke Di̇denur Sak, Seher Yaylaci
N-Cadherin Mimetic Hydrogels Drive Superior Regenerative And Paracrine Responses In 3d Cultures Of Adipose-Derived Mesenchymal Stem Cells, Demet Kaçaroğlu, Alper Murat Ulaşli, Aybüke Di̇denur Sak, Seher Yaylaci
Turkish Journal of Biology
Background: Cadherin-based biomaterials play a pivotal role in influencing the fate of mesenchymal stem cells (MSC). Enhancing the adhesion of adipose tissue-derived MSCs has been shown to augment their paracrine effects while N-cadherin biomaterials have been suggested to regulate the paracrine effects of MSCs via specific growth factors although the precise mechanisms underlying this regulation remain insufficiently understood. This study aims to compare the effects of a 3D N-cadherin mimetic environment on cell viability, apoptosis, extracellular matrix regulation, and growth factor expression with those observed in traditional 2D and 3D spheroid cultures. Additionally, the study seeks to evaluate the …