Digital Commons Network^™

A Joint Optimization-Based Novel Attack For Genomic Beacon Reconstruction, Kousar Saleem, Si̇nem Sav

Turkish Journal of Electrical Engineering and Computer Sciences

Genomic data sharing has become an essential component of biomedical research, enabling large-scale collaborations and accelerating discoveries in human genetics. To balance the need for accessibility with privacy concerns, several controlled-access mechanisms have been proposed, including genomic beacons. Genomic beacons answer simple presence/absence queries about specific genetic variants. However, prior work has demonstrated that beacons remain vulnerable to genome reconstruction attacks, where an adversary can recover large portions of participants’ genomes using summary statistics. Building on insights from prior reconstruction attacks, we introduce an approach that unifies SNP correlation and allele frequency alignment objectives within a single-stage joint optimization framework. …

Automated Software Size Measurement Using Multilingual Domain-Adapted Language Models, Samet Tenekeci̇, Hüseyi̇n Ünlü, Burak Keçeci̇, Muhammed Efe İnci̇r, Onur Demi̇rörs

Turkish Journal of Electrical Engineering and Computer Sciences

Software Size Measurement (SSM) is crucial for estimating required project effort as well as budget and schedule. However, many small and medium-sized companies struggle to apply objective SSM due to limited resources and lack of expertise. This often leads to inaccurate estimates and project overruns. There is a need for practical, low-resource solutions that support these tasks without requiring expert involvement. Motivated by this challenge, this study proposes an automated software size measurement approach that formulates the measurement task as supervised regression over natural language requirements, using domain-adapted transformer models. We construct large-scale Turkish and English software engineering corpora to …

Simplicity In Le-Semigroups Via Partitions Of Full Words, And Its Applications To Regularity Conditions Induced By Linear Inequalities, Nareupanat Lekkoksung

Turkish Journal of Mathematics

The concept of simplicity in le-semigroups has been used to characterize the coincidence of ideal elements and to study Khayopulu–Green’s relations. Several types of simplicities are known, including two-sided simplicity, left simplicity, right simplicity, bisimplicity, quasisimplicity, and biinterior simplicity. A natural question arises: are there further notions of simplicity for le-semigroups? If so, how are they related? By employing the notion of partition ideal elements, we observe that several potential simplicities have not yet been explored. In this paper, we introduce new forms of simplicity in le-semigroups defined via partitions of full words, and we investigate the …

A Geometric Property Characterizing The 3d-Generalized Clothoids, Pascual Lucas, José-Antonio Ortega-Yagües

Turkish Journal of Mathematics

In this paper, we study 3D-generalized clothoids, defined as curves for which there exists another distinct curve, with proportional arclength parameter, such that the Darboux lines of both curves at corresponding points are the same. We prove that these curves are those for which the ratio of torsion and curvature τ/κ is a linear rational function of the arclength. We also show that any 3D-generalized clothoid can be constructed from a rectifying curve, which is of constant curvature in the case of a 3D-clothoid.

Multiplicative Lorentz Matrix Multiplication And The Motion On Multiplicative Lorentz Plane, Osman Keçi̇li̇oğlu, İlayda Durmaz, Hali̇t Gündoğan

Turkish Journal of Mathematics

In this paper, we define the multiplicative determinant for general n×n matrices, extending previous studies that were limited to lower-dimensional cases. Additionally, we introduce a novel matrix multiplication operation based on the multiplicative Lorentz inner product and conduct a thorough investigation of its algebraic properties. Furthermore, we explore rotational and reflectional transformations in the two-dimensional multiplicative Lorentz space L^*₂, supported by illustrative examples of these geometric motions.

On Fredholm Type Integral Equations In H\"{O}Der Spaces: Existence Of Solutions, Yasemi̇n Başci, Adi̇l Misir, Süleyman Öğrekçi̇

Turkish Journal of Mathematics

In this study, we investigate the existence of solutions for a quadratic integral equation of the Fredholm type. The analysis is conducted on a finite interval bounded by two arbitrary constants, where the unknown function is associated with a prescribed kernel and two operators satisfying specific regularity and boundedness conditions. The methodological framework of this work is built upon the classical Schauder fixed point theorem, complemented by the structural properties of Hölder spaces. The results obtained not only encompass but also extend several previous contributions in the literature, as the discussion is carried out within a generalized setting over the …

The Killing Magnetic Curves In The Anti-De Sitter Space H31, Uğur Dursun

Turkish Journal of Mathematics

In this paper, we study space-like, time-like and light-like Killing magnetic curves derived from Killing magnetic vector fields of the anti-de Sitter space H³₁ by using the half-space model H³₁ of H³₁. We find the first integrals of the system of nonlinear differential equations that describe the Killing magnetic curves corresponding to some Killing vector fields of H³₁, and then we give some particular solutions to obtain space-like, time-like and light-like magnetic curves of H³₁. Also, we calculate the curvature and torsion of some space-like and time-like …

A Non-Newtonian Approach To Screw Motion And Dual Numbers, Esra Parlak, Zehra Özdemi̇r

Turkish Journal of Mathematics

In this paper, we define multiplicative dual numbers, multiplicative dual vectors, scalars, and vector products associated with the multiplicative dual numbers. We give the base elements of multiplicative dual elliptic quaternions and their operational properties. We explain the rotation and translation motions in multiplicative dual elliptical quaternions. We provide the matrix representations of the screw motion using multiplicative dual elliptical quaternions. Thanks to these multiplicative dual elliptical quaternions, we explain the screw motion along with rotation and translation with theorems and proofs. We visualize this screw motion with mathematical programs by applying screw-ruled surfaces.

Cover And Contents

Turkish Journal of Mathematics

No abstract provided.

Examining The Effect Of Different Polycarbonate Greenhouse Cover Materials On Tomato Yield And Plant Development With Thermal Imaging, Candan Korkmaz, Nefi̇se Yasemi̇n Tezcan

Turkish Journal of Agriculture and Forestry

In this study, the effects of different polycarbonate (PC) greenhouse covering materials on the environmental microclimateand plant growth were examined using three research greenhouses. Two types of PC covering materials were tested: the first greenhousewas covered with UV-additive PC (UV PC), the second greenhouse with UV+Infrared (IR) additive PC (UV+IR PC), and the third(control) greenhouse had UV-additive PC on the sidewalls and polyethylene (PE) covering material (UV PC+PE) on the roof. Themeasured fundamental parameters included total radiation transmittance, photosynthetically active radiation (PAR) transmittance,temperature, and relative humidity. Plant development was monitored and leaf temperatures were measured using a thermal camera atvarious …

Bioactive Profile And Mineral Composition Of Fruit Extracts From Four Wild Hawthorn (Crataegus Spp.) Species, Özlem Çakir, Kübra Çinar Topçu, Abdurrahman Sefali, İshak Bayyi̇ği̇t, Gülçe İlhan, Jyoti̇ Singh

Turkish Journal of Agriculture and Forestry

This study compared the antioxidant capacity, total phenolic content (TPC), phenolic composition, lipid oxidation level, andmineral profiles of extracts obtained from four wild hawthorn species (Crataegus tanacetifolia, C. orientalis subsp. orientalis, C. orientalissubsp. szovitsii, and C. monogyna) collected from northeastern Türkiye. Significant interspecific variations were observed in DPPH,FRAP, and CUPRAC assays. While C. monogyna had the highest reducing capacity and TPC, C. orientalis subsp. szovitsii had the highestDPPH activity. Ultra-high performance liquid chromatography coupled to tandem mass spectrometry analysis showed that catechin,epicatechin, chlorogenic acid, and quinic acid were the major phenolics, and were particularly abundant in C. monogyna. Despitehaving a …

Functional Characteristics Of Ice Creams Enriched With Aronia Melanocarpa And Sambucus Nigra L. Extracts, Murat Emre Terzi̇oğlu, Emi̇ne Maci̇t

Turkish Journal of Agriculture and Forestry

In this study, the effects of Aronia melanocarpa and Sambucus nigra L. extracts added at different concentrations (0.5%, 1%,and 1.5%) on the physicochemical, sensory, microbiological, antioxidant capacity (DPPH• and ABTS•+ radical scavenging activity, TPC,TFC, and TAC) antidiabetic (α-amylase and α-glucosidase inhibition), and anti-Alzheimer properties (AChE inhibitory activity) of icecream were investigated. According to the statistical analysis results, extract addition did not have an effect on the total dry matter, fatand ash ratios of the ice cream samples (p > 0.05), but it had an effect on the protein ratio, viscosity, and first drip time at the level ofp < 0.05. The addition of extract positively affected the DPPH• radical scavenging activity IC50 and ABTS•+ radical scavenging activityIC50 values of the ice cream samples, and also increased the TPC, TFC, and TAC values. Indeed, a decrease in the IC50 values of DPPH•and ABTS•+ radical scavenging activities indicates an increase in antioxidant activity. The highest TPC, TFC, and TAC values weredetected in the A-1.5 sample (sample containing 1.5% A. melanocarpa extract) as 749.33 mg GA/kg, 434.70 mg QE/kg, and 290.97 mg/kg, respectively. Similarly, the highest α-amylase inhibitory activity (23.08%), the highest α-glucosidase inhibitory activity (10.41%) andthe highest AChE inhibitory activity (14.70%) were observed in the A-1.5 sample. Extract addition had no effect on microbiologicalproperties and sensory properties except texture. The results of this study showed that A. melanocarpa, S. nigra L. extracts can be usedas a natural additive with antioxidant, antidiabetic and anti-Alzheimer activities in ice cream production.

Towards The Assessment Of E-Flows: A Fish-Based Approach For The Tiber River Basin (Central Italy), Antonella Carosi, Francesca Lorenzoni, Fatemeh Zarei, Rachele Brustenga, Lucio Di Matteo, Daniela Valigi, Corrado Cencetti, Carlo Cardellini, Stefano Casadei, David Cappelletti, Massimo Lorenzoni

Turkish Journal of Zoology

Estimating ecological flows (EFs) in rivers is crucial for meeting the Water Framework  Directive (WFD) 2000/60/EC goals. To develop an EF model, it is  essential to use biological indicators to reliably record the impacts of human-induced  alterations on aquatic ecosystems. The adaptability of fish to annual flow variability  makes them a significant biological quality element (BQE). Consequently, using fish  as bioindicators is a powerful tool for assessing the impact of changes in the  hydrological regime on the natural communities within a river system. The new index  of the ecological status of fish communities (NISECI) is a methodology developed in  Italy …

Chlorella Vulgaris Measurements Using Full-Spectrum Goniometer For Optically Complex Inland Water Monitoring, Pinar Gürbüzer, Uğur Murat Leloğlu

Turkish Journal of Zoology

Rising environmental stressors, including climate change, nutrient loading, pollution,  and anthropogenic impacts, have made the continuous monitoring of lake water  quality increasingly essential. While in situ methods offer high precision, satellite-based remote sensing is essential for capturing large-scale, long-term changes and  accessing remote or extreme environments. To complement these approaches, we  developed a cost-effective in situ optical measurement system specifically designed  for optically complex inland waters. T he instrument enables detailed optical  characterization across scattering angles from 0° to 160° and wavelengths between  423 and 728 nm, covering both visible and near-infrared regions. Initial validation was  performed using monocultures of …

Changes In Metabolomics And Tissue Architectural Alterations Jointly Ameliorate Salt Mediated Injuries In Nigella Sativa L., Noreen Akhter, Ayesha Ali, Muhammad Aqeel, Muhammad Muslim Shahnaz, Saima Iqbal, Ayesha Riaz, Mohammed O. Alshahrani, Ali Noman, Noreen Khalid, Khairah M. Alwutayd Alomran, Fahad Mohamed Al-Zuibar

Turkish Journal of Agriculture and Forestry

This study evaluated plant resistance to salinity across varying salt concentrations: 0, 50, 100, 150, and 200 mM NaCl. Thestudy revealed how these salt levels affected the morphological, physiological, biochemical, and developmental characteristics of theplants. At the 50 mM NaCl treatment level, plant height dropped by 8% in comparison to the control. The shoot fresh and dry weightsof every plant subjected to different levels of salt stress decreased noticeably. At 200 mM NaCl, the plants fresh weight of root decreasedby the greatest percentage (42.8%). The total number of chlorophyll a and chlorophyll b in Nigella sativa L. was significantly lower …

Chrysin Alleviates Salt Stress By Enhancing Antioxidant Enzymes, Nutrient Balance, And Phytohormone Contents In Forage Pea, Sedat Severoğlu

Turkish Journal of Agriculture and Forestry

This study aimed to evaluate the potential protective effects of chrysin (Chr), a flavonoid compound, on growth, biochemical,hormonal, and nutrient levels in forage pea (Pisum sativum ssp. arvense L.) seedlings under NaCl-induced salt stress. The experimentwas conducted under controlled greenhouse conditions in a completely randomized design with three different concentrations of Chr(Chr0: 0 mM, Chr1: 0.1 mM, and Chr2: 0.5 mM Chr) and three levels of salt stress (S0: 0 mM, S1: 100 mM, and S2: 200 mM NaCl),resulting in nine treatment combinations (T0: Chr0S0, T1: Chr0S1, T2: Chr0S2, T3: Chr1S0, T4: Chr1S1, T5: Chr1S2, T6: Chr2S0, T7: Chr2S1, andT8: …

Effects Of Gamma Irradiation On Antioxidant Enzyme Activities In Black Carrot Callus Under Drought Stress, Damla Turan Büyükdi̇nç, Di̇lruba Tabay Sümbül, Sheikh Mansoor

Turkish Journal of Agriculture and Forestry

Daucus carota L. (carrot) is a commercially significant root vegetable widely cultivated in temperate regions for its edible taproot and valued for its high nutritional content. This study aimed to investigate the effects of drought stress on callus tissues of the Hatay black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) genotype and to determine the impact of different gamma radiation doses on antioxidant enzyme activities. Black carrot callus tissues were exposed to gamma irradiation at doses of 0, 7, 8, and 9 Gy to evaluate their responses to drought stress. Antioxidant enzyme activities, including superoxide dismutase (SOD), …

Production Of The Antitumor Compound Deoxyharringtonine By Suspension-Culturedcells Of Cephalotaxus Hainanensis, Liang Wang, Muhammad Mubashar Zafar, Chongyu Wu, Zhiqiang Xiong, Jingyi Sun, Huapeng Sun, Hanqing Cong, Xuefei Jiang, Mahmoud F. Seleiman, Fei Qiao, Peter Nick

Turkish Journal of Agriculture and Forestry

Plant cell fermentation can be a sustainable biotechnological alternative to the wild collection of medicinal plants. As aparadigm, we explored the potential of using the highly endangered endemic tree Cephalotaxus hainanensis, which accumulatescephalotaxine esters—potent anticancer compounds. We successfully established a suspension cell line able to convert cephalotaxineinto its esters, including deoxyharringtonine, harringtonine, isoharringtonine and homoharringtonine at a remarkable maximalconversion rate of up to 86%, when supplemented with L-homoleucine, a precursor for the side chains of these esters. Furthermore, byadding elicitors, we were able to enhance the yield significantly beyond the values expected from the complete conversion of the addedcephalotaxine. In …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Influence Of Plasticizer Type On The Structure And Drug Release Characteristics Of Lm-Pectin Hydrogels, Banu Kocaağa, Fatma Seni̇ha Güner

Turkish Journal of Chemistry

This study investigated the effects of different plasticizers—castor oil (CO), polyvinylpyrrolidone (PVP), and polyethylene glycol (PEG) with varying molecular weights (MWs)—on the structure and drug-release performance of low-methoxyl pectin (LM-pectin) hydrogels. Theophylline was used as a model drug to evaluate release behavior under physiologically relevant conditions. The incorporation of plasticizers modulated polymer–polymer interactions, swelling behavior, and thermal properties, thereby affecting drug-release kinetics. CO, a hydrophobic triglyceride, created microdomain-induced diffusion pathways; PVP, containing water-affinitive lactam units, facilitated moisture-driven plasticization; and PEG (MW 400/1000/1500), with hydroxyl-terminated chains, established hydrogen bonds with pectin. Structural analyses (FTIR and DSC) revealed that CO disrupted pectin …

Antioxidant Potential Of Sulfenimides In Waste Walnut Oil Biodiesel: Kinetic Stability, Phosphomolybdenum Activity, And Reducing Power Capacity, Nalan Türköz Karakullukçu, Hasan Yakan, Volkan Murat Yilmaz, Hali̇t Muğlu, Semi̇ha Yeni̇gün, Hali̇l Kütük

Turkish Journal of Chemistry

This study investigated the influence of synthetic sulfenimides on biodiesel–diesel fuel blends. Three previously synthesized sulfenimide derivatives were structurally characterized using spectroscopic techniques. We evaluated their antioxidant properties through phosphomolybdenum activity and reducing power capacity assays. The tested fuel samples were designated as D100, B10D90, B10D90_AA (ascorbic acid), B10D90_3, B10D90_2, and B10D90_1. The effect of adding 2000 ppm of the additive was measured using an Oxifast instrument following the ASTM D7545 standard, and the results were compared to those of the chemical antioxidant ascorbic acid. Inhibition time values were derived from the oxidation stability results. The starting temperatures for crystallization …

Comparative Computational Study Of Sulfur-Donor Additives For Stabilization Of Fapbi3 Perovskites, Ilnar Nurgaliev, Akbarxon Hamzayev, Murad Marasulov, Zavkiddin Julliev, Akhmad Oblakulov, Nigmat Ashurov

Turkish Journal of Chemistry

A multiscale computational investigation integrating density functional theory (DFT) and molecular dynamics (MD) simulations was conducted to elucidate the mechanisms through which sulfur-containing donor molecules stabilize the photoactive α-phase of formamidinium lead iodide (FAPbI3) perovskites. The binding energetics, charge-transfer behavior, and hydrogen-bonding interactions of thiourea (TU), thiosemicarbazide (TSC), thiocyanate (SCN–), and diethyldithiocarbamate (DTC) were systematically analyzed. DFT results revealed pronounced Pb–S coordination and multidentate hydrogenbonding, with binding energies following the trend SCN–>TSC>DTC>TU. Thermodynamic analysis demonstrated that these additives lower the Gibbs free energy difference, thereby stabilizing the black α-phase, with TSC, TU, and to a lesser extent …

Zoledronic Acid-Loaded Hap–Sio2–Camoo4:Eu3+ With Luminescent Properties As A Novel Drug Delivery System, Emi̇ne Kutlu, Muhammad Asim Ali, Fati̇h Mehmet Emen, Canan Vejselova Sezer, Hati̇ce Mehtap Kutlu

Turkish Journal of Chemistry

CaMoO4:Eu3+-functionalized hydroxyapatite–silica (HAp–SiO2–CaMoO4:Eu3+) core–shell nanocomposites were synthesized for the first time and evaluated as a multifunctional drug delivery and imaging platform. HAp–SiO2 nanocomposites were prepared via a hydrothermal route and subsequently functionalized with a luminescent CaMoO4:Eu3+ shell using the Pechini sol–gel method. Structural analyses confirmed the successful coexistence of HAp, SiO2, and CaMoO4:Eu3+ phases, while electron microscopy revealed spherical core–shell morphologies. Dynamic light scattering measurements showed average hydrodynamic particle sizes of approximately 1085 nm for HAp–SiO2 and 1427 nm for HAp–SiO2–CaMoO4:Eu3+ nanocomposites, indicating particle clustering in aqueous media, which is consistent with the low surface charge of the particles. The …

Development And Optimization Of A Novel Spectroscopic Method To Monitor Crystallization Behavior Of Bcs-Ii Drug, Uditi Handa, Anuj Malik, Kumar Guarve

Turkish Journal of Chemistry

This study investigated the crystallization behavior of dextromethorphan hydrobromide, a class II drug, to improve understanding of its supersaturation potential and formulation design. Conventional methods often lack the sensitivity or scalability needed for accurate detection of early nucleation events. To overcome these limitations, a novel process tracks real-time absorbance below turbidity levels to detect early molecular aggregation and phase separation. Crystallization kinetics of the drug was assessed at concentrations of 0.1, 0.2, and 0.3 mg/mL using three analytical techniques, namely, isothermal crystallization (baseline), ultraviolet (UV) absorbance (turbidity monitoring, UV-TM), and an optimized UV absorbance graphical method (UV-GM) (novel process). Induction …

Efficient Electrocatalytic Activity Of A Fe-Mof Based Cathode Catalyst In Pemfcs, Susmita Singh, Tanya Nishad, Debasmita Paul, Sumi Ganguly, Soumyabrata Goswami

Turkish Journal of Chemistry

Advancements in cost-effective and efficient alternative energy sources are critical for socioeconomic development. In this study, Iron-based metal–organic framework (Fe-MOF) electrocatalyst was fabricated using an Fe salt and ligand. Several surface characterization methods, including Fourier Transform-Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), and X-ray diffraction (XRD), were used to characterize the electrocatalyst. Additionally, using Chronoamperometry (CA), Electrochemical Impedance Spectroscopy (EIS), Linear Sweep Voltammetry (LSV), and Cyclic Voltammetry (CV), the electrocatalytic behaviour in a cathodic reaction in PEMFCs is investigated. The study showed the material’s exceptional chemical or surface stability, and great surface morphology of the material that facilitated the cathodic …

Comparison Of The Mars And Xgboost Algorithms For Predicting Body Weight In Kalahari Red Goats, Louis Thobela Tyasi, Cem Tirink, Kwena Mokoena, Hasan Önder, Uğur Şen, Demet Çanga Boğa, Tolga Tolun, İsmai̇l Gök, Yüksel Aksoy, Lütfi̇ Bayyurt, Ömer Faruk Yilmaz

Turkish Journal of Veterinary & Animal Sciences

Estimating goat body weight from morphometric traits is essential for growth monitoring, health management, and welfare. Accurate weight informs nutrition, clinical interventions, and mating decisions. In this study, the MARS and XGBoost algorithms were used to estimate the live weight of Kalahari Red goats based on body measurements. A dataset containing body length (BL), birth type (single, twin, or triplet), withers height (WH), rump height (RH), and heart girth (HG) information for 200 goats was used in the training and testing of the models. The performances of the models were evaluated with the goodness-of-fit criteria. XGBoost showed a performance of …

Human Bone Marrow-Mesenchymal Stem Cells Differentiation Into Brain-Like Endothelial Cells, Yomna Soliman, Güli̇n Baran, Nur Mustafaoğlu

Turkish Journal of Biology

Background/aim: Brain microvascular endothelial cells (BMECs), which constitute the blood–brain barrier (BBB), are essential for maintaining central nervous system homeostasis. Like BMECs, multipotent mesenchymal stem cells (MSCs) originate from the mesodermal lineage. Thus, MSCs may serve as a direct and efficient cellular source for BMEC-like differentiation. Notably, differentiation of human induced pluripotent stem cells (hiPSCs) into BMECs typically involves a 2-step protocol: inducing mesodermal commitment followed by endothelial specification. In contrast, direct differentiation from MSCs could bypass the initial mesodermal induction step, offering a streamlined alternative. This study tested a novel strategy for differentiating MSCs into brain-like endothelial cells (BLECs), …

Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar

Turkish Journal of Biology

Background/aim: Pyrazole derivatives are of growing interest due to their diverse pharmacological activities. However, their biological activity is often highly sensitive to subtle structural modifications. Existing quantitative structure–activity relationships (QSAR) approaches frequently fail to capture the conformational flexibility and nonlinear structure–activity relationships (SAR) of such heterocyclic scaffolds, creating a gap in the accurate prediction of their biological profiles. Therefore, there is a strong need for more robust and predictive computational frameworks. This study addresses this gap by integrating four-dimensional (4D)-QSAR descriptors with hybrid machine learning (ML) techniques to improve predictive accuracy and provide a more reliable tool for structure-based drug …

Quenching-Based Electrochemiluminescence Detection Of Chlorpyrifos Using A Portable Sensor Platform, Emre Dokuzparmak

Turkish Journal of Biology

Background/aim: Chlorpyrifos (CPF) is an organophosphate pesticide extensively used in agriculture, posing significant threats to human health due to its neurotoxic effects. Its presence in food products has raised considerable public health concerns, necessitating the development of rapid, sensitive, and reliable detection methods. This study aims to design and validate an electrochemiluminescence (ECL) sensor platform operating via a quenching-based mechanism to enable ultrasensitive detection of CPF in food matrices.

Materials and methods: The sensing strategy exploits the coreactant mechanism between 2-(dibutylamino)ethanol (DBAE) and [Ru(bpy)₃]²+ (tris(2,2′-bipyridyl)ruthenium(II)), wherein CPF suppresses the ECL emission by interfering with the excited-state electron transfer pathway. The …

Investigation Of Antimicrobial Synergism Of Actinomycin Derivatives From Streptomyces Parvus 35m1 Against Escherichia Coli Atcc 25922, Özge Can, Mustafa Ünver Kurt, Meli̇s Küçüksolak, Ataç Uzel, Erdal Bedi̇r

Turkish Journal of Biology

Background/aim: Limited drug development and increased antibiotic tolerance among Gram-negative bacteria have led researchers to consider combination therapy. Actinomycin derivatives, particularly actinomycin D, exhibit a wide range of bioactivities, including antibacterial effects. However, actinomycin D is less effective against Gram-negative pathogens. Therefore, it is essential to demonstrate the synergy of actinomycin D and its derivatives with clinically known antibiotics against Escherichia coli ATCC 25922 and investigate the effects on cellular morphology.

Materials and methods: Streptomyces parvus 35M1 isolated from coastal sediment in İzmir/Türkiye was identified via genome sequencing. Large-scale (30 L) fermentation followed by chromatographic purification yielded compounds 1 (actinomycin …