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Post-Mucilage Status Of The Teleost Fish Assemblages In The Sea Of Marmara, Mustafa Sari, Uğur Karadurmuş
Post-Mucilage Status Of The Teleost Fish Assemblages In The Sea Of Marmara, Mustafa Sari, Uğur Karadurmuş
Turkish Journal of Zoology
A frightening mucilage event occurred in the Sea of Marmara (SoM) from November 2020 to July 2021, leaving devastating effects on maritime industries, fishing activities and the benthic ecosystem. The mucilage led to intense fish mortalities, particularly affecting species like smelt, anchovy, and picarel, with severe consequences for benthic ecosystems and various marine species. This study aims to analyze the possible long-term effects of the recent mucilage disaster on species diversity and biomass by assessing the current status of teleost fish assemblages in the SoM. The data set is based on bottom trawl surveys carried out at 52 points at …
Occlusal Surface Variations In Genetically-Identified Specimens Of The Genus Apodemus (Mammalia: Rodentia) Distributed In The Northern Anatolia Region And Three Turkish Islands: Gökçeada, Marmara Island And Bozcaada, Duygu Korkmaz, Engin Selvi̇, Nuri Yi̇ği̇t, Ercüment Çolak
Occlusal Surface Variations In Genetically-Identified Specimens Of The Genus Apodemus (Mammalia: Rodentia) Distributed In The Northern Anatolia Region And Three Turkish Islands: Gökçeada, Marmara Island And Bozcaada, Duygu Korkmaz, Engin Selvi̇, Nuri Yi̇ği̇t, Ercüment Çolak
Turkish Journal of Zoology
A total of 134 Apodemus samples, whose genetic diagnoses had been previously conducted, were morphologically examined from 39 localities in Northern Anatolia, Thrace, Gökçeada, Bozcaada and the Marmara Island. The variation boundaries of dental variations in the distribution areas of five Apodemus species (Apodemus flavicollis, Apodemus witherbyi, Apodemus sylvaticus, Apodemus uralensis, Apodemus mystacinus) included in the research were determined. The defining morphological characters of Apodemus species, which have a complex taxonomic status, and their variations according to regions were identified using samples that had undergone genetic diagnoses. It was determined whether geographical barriers such as the Marmara Sea, the Bosphorus …
The Common Wall Lizard Podarcis Muralis (Reptilia: Lacertidae) Shows Diverse Food Preferences And Intraspecific Difference: A Study Case From Bulgaria, Emiliya Vacheva, Borislav Naumov
The Common Wall Lizard Podarcis Muralis (Reptilia: Lacertidae) Shows Diverse Food Preferences And Intraspecific Difference: A Study Case From Bulgaria, Emiliya Vacheva, Borislav Naumov
Turkish Journal of Zoology
The Common wall lizard (Podarcis muralis) has the largest range among the genus Podarcis. Although there are a number of studies on its diet, data on regional level remains insufficient, particularly from a purely ecological perspective. We investigated 194 individual faecal samples of P. muralis obtained from two localities in western Bulgaria with the aim of clarifying the composition of the trophic spectrum of the species, as well as the intra-population characteristics in terms of age and sex. In one study site we compared the realized trophic niche (prey items from the faecal pellets) with the fundamental (invertebrates collected via …
Sexual Size Dimorphism Of Darevskia Schaekeli (Sauria: Lacertidae), Seyyed Saeed Hosseinian Yousefkhani, Saeed Morvari
Sexual Size Dimorphism Of Darevskia Schaekeli (Sauria: Lacertidae), Seyyed Saeed Hosseinian Yousefkhani, Saeed Morvari
Turkish Journal of Zoology
Sexual dimorphism has been established as one of the important evolutionary results in the process of sexual selection between males and females of different species. Distinct morphological features between males and females can also be seen in reptiles. Lizards of the genus Darevskia show sexual dimorphism, as Darevskia schaekeli was studied as an example. The morphological traits investigated between males and females of this species showed that head length, trunk length, length of forelimbs and hindlimbs as well as the number of femoral pores are more in males than in females. All these morphological traits, which were more in males …
Assessing Population Size And Survival Rate Of Pelophylax Bedriagae Caralitanus, In A Well-Protected Nature Park In Türkiye, Ayfer Şirin, Akın Kiraç, Gürçay Kıvanç Akyildiz, Eyup Başkale
Assessing Population Size And Survival Rate Of Pelophylax Bedriagae Caralitanus, In A Well-Protected Nature Park In Türkiye, Ayfer Şirin, Akın Kiraç, Gürçay Kıvanç Akyildiz, Eyup Başkale
Turkish Journal of Zoology
Estimating population trends provides valuable information for conservation biologists. Although there are many methods for estimating demographic rates, capture-mark-recapture (CMR) methods are known to be the most realistic method that can provide detailed data on individuals and populations, including the achievement of conservation goals. This study focused on determining the population trend of Pelophylax bedriagae caralitanus, Beyşehir frog using the CMR method in a protected area during the 2011 - 2019 breeding seasons. Our CMR data led to the selection of a model-considering constant survival rates, capture/recapture probabilities, and year-specific immigration/emigration patterns [Φ(··) y'(t) y''(t) p(··) = c(··) N(t)]-as the …
Elastic Strips Along Isotropic Curves In Complex 3-Spaces, Dae Won Yoon, Zühal Küçükarslan Yüzbaşi
Elastic Strips Along Isotropic Curves In Complex 3-Spaces, Dae Won Yoon, Zühal Küçükarslan Yüzbaşi
Turkish Journal of Mathematics
In this paper, we define the ruled surface in terms of the Darboux vector field of an isotropic curve in a complex 3-space, and we study the ruled surface as an elastic strip along the isotropic curve. First of all, we show that elastic strips along isotropic curves that serve critical points of the modified Sadowsky functional are characterized by three Euler-Lagrange equations. As a result, we give two conservation laws to characterize elastic strips of isotropic curves in complex 3-space and explain an isotropic helix in terms of the force vector. Finally, we give some examples to illustrate elastic …
A Study Of The Scattering Analysis Of The Multiplicative Sturm-Liouville Problem, Güler Başak Öznur, Güher Gülçehre Özbey, Yelda Aygar Küçükevci̇li̇oğlu, Rabia Aktaş Karaman
A Study Of The Scattering Analysis Of The Multiplicative Sturm-Liouville Problem, Güler Başak Öznur, Güher Gülçehre Özbey, Yelda Aygar Küçükevci̇li̇oğlu, Rabia Aktaş Karaman
Turkish Journal of Mathematics
The main purpose of this study is to examine the scattering analysis of a multiplicative Sturm-Liouville boundary value problem. Firstly, we find the Jost solution of this problem and give the Jost function to construct the scattering function of the problem. Secondly, we obtain asymptotic equations for Jost solution and investigate some properties of the Jost function. Moreover, we present other solutions of the problem by giving the relations between these solutions and Jost solution. Finally, we define the scattering function of this problem by using the Jost function and examine the basic properties of the scattering function.
Dynamics Of Compositions Of Some Lotka–Volterra Mappings Operating In A Two-Dimensional Simplex, Dilfuza Eshmamatova, Farrukh Yusupov
Dynamics Of Compositions Of Some Lotka–Volterra Mappings Operating In A Two-Dimensional Simplex, Dilfuza Eshmamatova, Farrukh Yusupov
Turkish Journal of Mathematics
In a number of applied problems (immunology, epidemiology, virology, etc.), there is a need to study the dynamics of the trajectories of the compositions of the Lotka–Volterra mappings. In this paper, some variants of these compositions are considered, in particular, the dynamics of the trajectories of the compositions of the Lotka–Volterra mappings acting in a two-dimensional simplex, with transitive tournaments, which can be applied in the study of these processes. Cards of fixed points are constructed for compositions and the characters of fixed points are studied.
A Novel Algorithm For The Virtual Screening Of Extensive Small Molecule Libraries Against Ercc1/Xpf Protein-Protein Interaction For The Identification Of Therapeutic Resistance-Bypassing Small Anticancer Molecules, Salma Ghazy, Lalehan Oktay, Serdar Durdagi
A Novel Algorithm For The Virtual Screening Of Extensive Small Molecule Libraries Against Ercc1/Xpf Protein-Protein Interaction For The Identification Of Therapeutic Resistance-Bypassing Small Anticancer Molecules, Salma Ghazy, Lalehan Oktay, Serdar Durdagi
Turkish Journal of Biology
Background and aim:Cancer cell’s innate chemotherapeutic resistance continues to be an obstacle in molecular oncology. This theory is firmly tied to the cancer cells’ integral DNA repair mechanisms continuously neutralizing the effects of chemotherapy. Amidst these mechanisms, the nuclear excision repair pathway is crucial in renovating DNA lesions prompted by agents like Cisplatin. The ERCC1/XPF complex stands center-stage as a structure specific endonuclease in this repair pathway. Targeting the ERCC1/XPF dimerization brings forth a strategy to augment chemotherapy by eschewing the resistance mechanism integral to cancer cells. This study tracks and identifies small anticancer molecules, with ERCC1/XPF inhibiting potential, within …
Circ-Mettl15 Stimulates The Aggressive Behaviors Of Papillary Thyroid Cancer Cells By Coordinating The Mir-200c-3p/Xiap Axis, Yuhao Huang, Xinyu Zeng, Yanling Cai, Yan Yang, Yujie Zhang, Yiqi Ma, Suping Li
Circ-Mettl15 Stimulates The Aggressive Behaviors Of Papillary Thyroid Cancer Cells By Coordinating The Mir-200c-3p/Xiap Axis, Yuhao Huang, Xinyu Zeng, Yanling Cai, Yan Yang, Yujie Zhang, Yiqi Ma, Suping Li
Turkish Journal of Biology
Background and objective: Thyroid cancer is the most common malignant tumor in the endocrine system. Papillary thyroid carcinoma (PTC) accounts for the vast majority of cases in this cancer. Recently, the vital role of circular RNA (circRNA) has been acknowledged in various cancers. However, to date, few studies have examined the roles of circRNAs in PTC. Therefore, this research aimed at exploring the function and mechanism of circ-methyltransferase-like 15 (METTL15) in PTC cells.Methods: First, quantitative measurements of circ-METTL15, miR-200c-3p, and X-linked inhibitor of apoptosis protein (XIAP) in PTC cells were completed with reverse transcription-quantitative polymerase chain reaction or Western blot …
Mir-770-5p-Induced Cellular Switch To Sensitize Trastuzumab Resistant Breast Cancer Cells Targeting Her2/Egfr/Igf1r Bidirectional Crosstalk, Senem Noyan, Bala Gür Dedeoğlu
Mir-770-5p-Induced Cellular Switch To Sensitize Trastuzumab Resistant Breast Cancer Cells Targeting Her2/Egfr/Igf1r Bidirectional Crosstalk, Senem Noyan, Bala Gür Dedeoğlu
Turkish Journal of Biology
Background/aim: Studies highlighted the bidirectional crosstalk between the HER family members in breast cancer as resistance mechanism to anti-HER agents. Cross-signaling between HER2/EGFR and ER/IGF1R could play role in the development of resistance to therapeutics hence stimulating cell growth. To overcome this resistance, combined therapies targeting both pathways simultaneously have been proposed as an effective strategy. The involvement of miRNAs in resistance of targeted therapies like trastuzumab was demonstrated in recent studies. Hence the regulation of miRNAs in resistance state could reverse the cell behaviour to drugs. Previously we found that overexpression of miR-770-5p downregulated AKT and ERK expression through …
Non-Small Cell Lung Cancer Treatment: Current Status Of Drug Repurposing And Nanoparticle-Based Drug Delivery Systems, Tugba Gul Inci, Serap Acar, Di̇lek Balik
Non-Small Cell Lung Cancer Treatment: Current Status Of Drug Repurposing And Nanoparticle-Based Drug Delivery Systems, Tugba Gul Inci, Serap Acar, Di̇lek Balik
Turkish Journal of Biology
Drug repurposing is the strategy of drug utilization for a treatment option other than the intended indications and has increased over the past decades, especially within cancer nanomedicine. Cancer nanomedicine has been facilitated through nanoparticle-based (NP-based) delivery systems which can combat NSCLC via recent advances in nanotechnology and apply its benefits to existing drugs. An effective therapeutic solution could be gained via repurposing and accelerated via NP-based drug delivery systems. This review aims to present an overview of NSCLC treatments with a special focus on drug repurposing with details of clinical study advances and NP-based drug delivery systems for NSCLC. …
Nampt, Il-6, And Vaspin Gene Expressions And Serum Protein Levels In Type 2 Diabetes Mellitus And Related Complication, Süheyla Pınar Çelik, Damla Nur Parıltı, Leyla Açık, Mehmet Muhittin Yalçın, İlhan Yetkin, Eldeniz Yunusov
Nampt, Il-6, And Vaspin Gene Expressions And Serum Protein Levels In Type 2 Diabetes Mellitus And Related Complication, Süheyla Pınar Çelik, Damla Nur Parıltı, Leyla Açık, Mehmet Muhittin Yalçın, İlhan Yetkin, Eldeniz Yunusov
Turkish Journal of Biology
Type 2 diabetes (T2DM) is the most common type of diabetes and occurs due to insufficient insulin secretion or inability to use existing insulin and the effects of environmental factors. Although there are many studies on the pathophysiology of T2DM, the mechanisms playing a role in the pathogenesis of insulin resistance and pancreatic beta-cell dysfunction have not been fully elucidated. Some adipokines secreted from adipose tissue, which are the primary regulators of insulin resistance, affect immune and inflammatory functions. Altered adipokine profiles have been observed in obesity and T2DM, leading to severe metabolic risks and changes in insulin sensitivity. This …
Improving The Water Solubility Of Cannabidiol Using A Peptide Carrier, Melek Parlak Khalily
Improving The Water Solubility Of Cannabidiol Using A Peptide Carrier, Melek Parlak Khalily
Turkish Journal of Chemistry
Cannabidiol (CBD), nonpsychotropic cannabinoid found in Cannabis sativa, is a very promising drug candidate offering many differential effects such as sedative, antiinflammatory, antioxidant, and neuroprotective properties. Nevertheless, the therapeutic use of CBD is hindered by its lack of water solubility and relatively low bioavailability. Various carriers have been used to address the solubility issues of CBD and other highly lipophilic drugs so far. However, self-assembled peptide nanostructures as carrier have not been used to improve the water solubility of CBD yet. In this study, a self-assembling peptide micelle was demonstrated to be an effective vehicle for encapsulation of CBD and …
Computational Drug Repurposing Effort For Identifying Novel Hits For The Treatment Of Diseases Such As Endometriosis, Uterine Fibroids, And Prostate Cancer, Ahmet Buğra Ortaakarsu, Hi̇lal Medetali̇beyoğlu
Computational Drug Repurposing Effort For Identifying Novel Hits For The Treatment Of Diseases Such As Endometriosis, Uterine Fibroids, And Prostate Cancer, Ahmet Buğra Ortaakarsu, Hi̇lal Medetali̇beyoğlu
Turkish Journal of Chemistry
This research aimed to identify potential drug compounds from the ZINC15 molecule database that could effectively treat GnRH1R-related diseases. The study utilized molecular docking and molecular dynamics methods to achieve this goal, which is crucial in drug repurposing research. The virtual screening process involved analyzing known drug compounds using molecular docking. Additionally, molecular dynamics simulations and MM-GBSA were employed to evaluate the stability of the complexes and determine the interactions between the compounds and protein structure. As a result, this study provides significant insights for treating diseases such as endometriosis, uterine fibroids, and prostate cancer related to GnRH1R. The study …
Supramolecular Solvent-Based-Vortex-Assisted-Dispersive Liquid Liquid Microextraction Of Sudan Black B In Food Samples Prior To Spectrophotometric Detection, Fi̇gen Erek, Mustafa Tüzen
Supramolecular Solvent-Based-Vortex-Assisted-Dispersive Liquid Liquid Microextraction Of Sudan Black B In Food Samples Prior To Spectrophotometric Detection, Fi̇gen Erek, Mustafa Tüzen
Turkish Journal of Chemistry
A new, simple and rapid spectrophotometric method was developed for determination of Sudan Black B in food products by supramolecular solvent-based-vortex-assisted-dispersive liquid liquid microextraction (SUPRAS-VA-DLLME). Extraction solvent type, volume of solvent, pH, volume of THF, centrifugation time, vortex time, and sample volume were investigated as optimization parameters of the developed method. Under the optimum conditions, limit of detection and limit of quantification, preconcentration factor and enhancement factor of the developed method were calculated to be 9.01 µg L–1, 29.73 µg L–1, 20, and 55, respectively. The developed microextraction method was successfully applied to food samples for the determination of Sudan …
Sensitive And Accurate Determination Of Oil-Soluble And Water-Soluble Organosulfur Compounds In Garlic Matrix Using Reversed Phase-High Performance Liquid Chromatography, Ümmügülsüm Polat Korkunç, Buse Tuğba Zaman, Sezgi̇n Bakirdere, Emine Karakuş
Sensitive And Accurate Determination Of Oil-Soluble And Water-Soluble Organosulfur Compounds In Garlic Matrix Using Reversed Phase-High Performance Liquid Chromatography, Ümmügülsüm Polat Korkunç, Buse Tuğba Zaman, Sezgi̇n Bakirdere, Emine Karakuş
Turkish Journal of Chemistry
Garlic is in the family Liliaceae and has many different constituents such as organic sulfur compounds, amino acids, carbohydrates, minerals, and vitamins. In this work, a simple, sensitive, and accurate analytical method was developed for the determination of selected organosulfur compounds (OSCs) in garlic bulbs using reversed phase-high performance liquid chromatography (RP-HPLC). Oil-soluble and water-soluble OSCs were extracted from the garlic samples via acetonitrile and deionized water, respectively. The OSCs were separated on a Phenomenex C18 (250 mm, 4 mm, 5mm) column and the monitoring was performed with a UV detector at 220 nm. An isocratic mobile phase comprising of …
Preparation Of Cholesterol-Imprinted Polymer For Selective Adsorption Of Cholesterol From Gastrointestinal Mimicking Solution, Veyi̇s Karakoç, Erol Erçağ
Preparation Of Cholesterol-Imprinted Polymer For Selective Adsorption Of Cholesterol From Gastrointestinal Mimicking Solution, Veyi̇s Karakoç, Erol Erçağ
Turkish Journal of Chemistry
The purpose of this study is to synthesize a highly selective adsorbent to remove cholesterol, one of the most important causes of cardiovascular diseases, from the intestinal mimic solution (IMS). For this purpose, cholesterol imprinted polymers were synthesized by suspension polymerization method using the molecular imprinting technique. In the first step, the functional monomer MATyr with hydrophobic character was synthesized. Then, the cholesterol-MATyr monomer precomplex was formed and the polymerization process was carried out by adding cross-linkers with the comonomer HEMA. The synthesized polymer poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-tyrosine methylester) poly(HEMA–MATyr) was characterized by FTIR and SEM. The cholesterol adsorbing behavior of the …
Performance Test Of Zn-Astaxanthin Complex-Sensitized Solar Cell: Effect Of Light Intensity On Open-Circuit Voltage And Short-Circuit Current Values, Septiani Septiani, Winda Rahmalia, Thamrin Usman
Performance Test Of Zn-Astaxanthin Complex-Sensitized Solar Cell: Effect Of Light Intensity On Open-Circuit Voltage And Short-Circuit Current Values, Septiani Septiani, Winda Rahmalia, Thamrin Usman
Turkish Journal of Chemistry
The sensitizer is one of the most essential dye-sensitized solar cell (DSSC) components. In the present research, a Zn-astaxanthin complex was investigated as a sensitizer, compared to pure astaxanthin. The complex with a 1:1 mole ratio between astaxanthin and Zn2+ was synthesized in a reflux reactor at 37–60 °C. The product was analyzed using Proton Nuclear Resonance (1H-NMR), which indicates the presence of chelate formation between Zn2+ with two atoms of oxygen on the terminal cyclohexane ring of astaxanthin. The interaction of sensitizers (astaxanthin and Zn-astaxanthin) on the photoelectrode surface in this study was analyzed using a Fourier Transform Infra-Red …
Evaluation Of P(Hema-Co-Nipam) Hydrogels For Removal Of Methylene Blue From Aqueous Solution:Isotherm, Kinetic, And Thermodynamic Studies, Hayri̇ye Mi̇ne Antep, Müni̇re Nalan Demi̇r, Cevher Gündoğdu Hizliateş, Si̇mge Öztürk, Eli̇f Esen
Evaluation Of P(Hema-Co-Nipam) Hydrogels For Removal Of Methylene Blue From Aqueous Solution:Isotherm, Kinetic, And Thermodynamic Studies, Hayri̇ye Mi̇ne Antep, Müni̇re Nalan Demi̇r, Cevher Gündoğdu Hizliateş, Si̇mge Öztürk, Eli̇f Esen
Turkish Journal of Chemistry
In this study, a novel adsorbent material, poly (2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide) (p(HEMA-co-NIPAM) hydrogel, was synthesized for the purpose of removing methylene blue (MB) from aqueous media. The synthesis of hydrogel was carefully conducted, and its properties were thoroughly examined using techniques such as Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The adsorption experiments conducted revealed a remarkable affinity of p(HEMA-co-NIPAM) hydrogel towards MB. The highest adsorption was observed when 0.05 g of the adsorbent were utilized, with optimal conditions at a pH of 6.0 and a temperature of 15 °C. This underscores the importance of …
Transdermal Delivery System To Release Phthalocyanine Photosensitizers For The Potential Treatment Of Skin Cancer With Pdt, Meryem Çamur Demi̇r, Fatma Kurşun Baysak, Caner Yahya Boyar, Ali̇han Toksoy, Fati̇h Algi
Transdermal Delivery System To Release Phthalocyanine Photosensitizers For The Potential Treatment Of Skin Cancer With Pdt, Meryem Çamur Demi̇r, Fatma Kurşun Baysak, Caner Yahya Boyar, Ali̇han Toksoy, Fati̇h Algi
Turkish Journal of Chemistry
This research aims to examine the transdermal release of water-soluble indium and zinc metallo phthalocyanine (InPc and ZnPc) compounds from the poly(vinyl alcohol) (PVA) membrane and the cytotoxicity effect of these Pcs on normal mouse fibroblasts (L929 fibroblast) and human melanoma (SK-MEL-30) cells. For this purpose, the effects of temperature, pH, drug concentration and membrane thickness on transdermal release were investigated in order to obtain the optimum transdermal release profile by preparing PVA membranes with different thicknesses and crosslinked by heat treatment. Optimum drug release was found to be 85.36% using 6 µm thick PVA membrane at 37 ± 0.5 …
Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya
Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya
Turkish Journal of Medical Sciences
Background/aim: Obesity is a chronic metabolic disease involving dysregulation of fat metabolism that affects 13% of the world’s population. Obesity has been linked to dyslipidemia with a lot of complication, including stroke, chronic kidney disease, fatty liver disease, and so on. One of the natural resources that have several potential effects including anticholesterol, antiobesity, and antidyslipidemia is the butterfly pea (Clitoria ternatea/CT). CT’s petal has been found to contain high levels of anthocyanins and tannins that can inhibit the biosynthesis of cholesterol and lipid. This study aims to investigate the antiobesity and antidyslipidemic effects of Clitoria ternatea extract (CTE).Materials and …
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
Turkish Journal of Medical Sciences
Background/aim: In practice, waiting 2–3 weeks for interpolation flaps pedicle division result in certain morbidities and discomfort for patient. The division time of flap pedicle depends on neovascularization from the recipient bed and includes wound healing stages. We aimed to investigate the effect of recombinant human epidermal growth factor (rhEGF) on the flap viability during early pedicle division.Materials and methods: Thirty-six rats were allocated to two main groups as control and study. A cranial based flap measuring 5 × 5 cm was elevated from the back, including all layers of the skin. While the cranial half of the defect was …
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Turkish Journal of Medical Sciences
Background/aim: There is no specific marker that can be applied to determine the severity of Behçet’s disease. The aim of this study is to investigate the potential of C-reactive protein (CRP)/albumin (CAR) ratio as a tool for assessing the severity of Behçet’s disease.Materials and methods: A retrospective crosssectional study was conducted by examining hospital archives. The CRP and albumin levels of Behçet’s disease patients who presented to our dermatology clinic over a three-year period from February 2020 to February 2022 were included, along with the identical laboratory parameters in the control group. The CAR ratio was calculated and statistically compared …
Serum And Urine Interferon-Inducible Protein 10, Galectin-9, And Siglec-1 As Biomarkers Of Disease Activity In Systemic Lupus Erythematosus, Şafak Mi̇ri̇oğlu, Suzan Çinar, Ömer Uludağ, Erdem Gürel, Sibel Varelci̇, Yasemin Özlük, Işın Kiliçaslan, Yasemin Yalçinkaya, Halil Yazici, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Serum And Urine Interferon-Inducible Protein 10, Galectin-9, And Siglec-1 As Biomarkers Of Disease Activity In Systemic Lupus Erythematosus, Şafak Mi̇ri̇oğlu, Suzan Çinar, Ömer Uludağ, Erdem Gürel, Sibel Varelci̇, Yasemin Özlük, Işın Kiliçaslan, Yasemin Yalçinkaya, Halil Yazici, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Turkish Journal of Medical Sciences
Background/aim: In this prospective study, we aimed to investigate the association of serum (s) and urine (u) IP-10, galectin-9, and SIGLEC-1 with disease activity in patients with systemic lupus erythematosus (SLE).Materials and methods: Sixty-three patients with active SLE (31 renal, 32 extrarenal) were included. Thirty patients with inactive SLE (15 renal, 15 extrarenal), 17 with renal active AAV, and 32 healthy volunteers were selected as control groups. Serum and urine IP-10, galectin-9, and SIGLEC-1 were tested using ELISA.Results: Levels of sIP-10 (p = 0.046), uIP-10 (p < 0.001), sGalectin-9 (p = 0.03), and uSIGLEC-1 (p = 0.006) were significantly higher in active SLE group compared to the inactive SLE; however, no differences were detected in the comparison of uGalectin-9 (p = 0.18) and sSIGLEC-1 (p = 0.69) between two groups. None of the biomarkers discriminated patients with active renal SLE from active extrarenal SLE. ROC analyses revealed an AUC of 0.63 (0.52–0.73) for sIP-10, 0.78 (0.68–0.86) for uIP-10, 0.64 (0.53–0.74) for sGalectin-9, and 0.68 (0.57–0.77) for uSIGLEC-1 in discriminating disease activity in SLE, which did not outperform C3 (0.75, 0.64–0.84) and C4 (0.72, 0.61–0.82). sIP-10 (p = 0.001), uIP-10 (p = 0.042), and uGalectin-9 (p = 0.009) were significantly increased in patients with active renal SLE compared to active renal AAV. sGalectin-9 (p < 0.001) and sIP-10 levels (p = 0.06) were decreased after 8 (5–22.5) months of treatment.Conclusion: sIP-10, uIP-10, sGalectin-9, and uSIGLEC-1 reflect global disease activity in SLE but do not outperform C3 and C4. sIP-10 and uIP-10 may be specific for active SLE compared to active AAV. sIP-10 and sGalectin-9 might be valuable in monitoring response after treatment.
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: There is limited information on the pathologic changes in the small airways among obese and nonobese patients with obstructive sleep apnea syndrome (OSAS). Impulse oscillometry (IOS) measures airway resistance and reactance independently of patient effort. This study aimed to compare airway resistance in small airways using IOS between obese and nonobese patients with OSAS.Materials and methods: In this real-life cross-sectional study, demographic information was collected from obese and nonobese subjects diagnosed with moderate and severe OSAS without any other underlying diseases. Spirometry and IOS measurements were conducted, and the values of both groups were statistically analyzed.Results: The nonobese group …
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Turkish Journal of Veterinary & Animal Sciences
Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy …
Effect And Mechanisms Of Conifer And Broadleaf Mixtures On The Soil Characteristics In Limestone Mountains, Xueping Zhang, Yuhua Ma, Songling Fu, Jingjing Qian, Qi Zhu, Chun Feng, Zihao Li, Wenhao Zhu, Han Chen
Effect And Mechanisms Of Conifer And Broadleaf Mixtures On The Soil Characteristics In Limestone Mountains, Xueping Zhang, Yuhua Ma, Songling Fu, Jingjing Qian, Qi Zhu, Chun Feng, Zihao Li, Wenhao Zhu, Han Chen
Turkish Journal of Agriculture and Forestry
In the restoration process of limestone mountain ecosystem, the interaction mechanism, between vegetation and soil are the core scientific issues for a better understanding of ecological restoration and ecosystem stability. Based on this, four types of 30 year old artificial forest communities with different coniferous and broad-leaved mixed ratios (0-20 %, 20 - 50 %, 50 – 80 %, 80 – 100 %) in typical limestone mountainous areas of the northern subtropical region are used as research objects to measure understory vegetation diversity, litter, and fine root characteristics. The impact of different mixing ratios on understory vegetation restoration and soil …