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Efficient Entrapment Of Kluyveromyces Marxianus Dbkkuy-103 In Polyvinyl Alcohol Hydrogel For Ethanol Production From Sweet Sorghum Juice, Kanchana Nonthasen, Weera Piyatheerawong, Pornthap Thanonkeo
Efficient Entrapment Of Kluyveromyces Marxianus Dbkkuy-103 In Polyvinyl Alcohol Hydrogel For Ethanol Production From Sweet Sorghum Juice, Kanchana Nonthasen, Weera Piyatheerawong, Pornthap Thanonkeo
Turkish Journal of Biology
The aim of this investigation was to optimize immobilization conditions to entrap Kluyveromyces marxianus DBKKUY-103 during ethanol fermentation from sweet sorghum juice using a response surface methodology. The effects and interactions of variables involved in cell entrapment using polyvinyl alcohol and sodium alginate were studied through a fractional factorial design. The results suggested that the primary variables involved in cell entrapment that significantly affected ethanol fermentation were sodium sulfate concentration, polyvinyl alcohol, and sodium alginate contents (P < 0.01). Subsequently, these variables were optimized for the preparation of cell entrapment based on response surface methodology and using central composite design. The results indicate that cell entrapment can achieve an ethanol concentration of 81.56 g L^{-1} under the following optimal conditions: bead gel diameter of 4.0 mm, calcium chloride concentration of 0.3 M, polyvinyl alcohol content of 10.09% (w v^{-1}), sodium alginate content of 3.39% (w v^{-1}), and sodium sulfate concentration of 0.44 M. Furthermore, statistical analysis of the model reveals that it adequately fit the experimental data (P < 0.01, R^2 = 0.9879). Therefore, this model can be used to efficiently prepare entrapped cells for ethanol production.
Activity Of Antioxidant Enzymes In The Liver Of Wild Boars (Sus Scrofa) From A Selenium-Deficient Area Depending On Sex, Age, And Season Of The Year, Dorota Jankowiak, Renata Pilarczyk, Radoslaw Drozd, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Gabriela Wysocka, Izabella Rzad, Arleta Drozd, Jaroslaw Kuba
Activity Of Antioxidant Enzymes In The Liver Of Wild Boars (Sus Scrofa) From A Selenium-Deficient Area Depending On Sex, Age, And Season Of The Year, Dorota Jankowiak, Renata Pilarczyk, Radoslaw Drozd, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Gabriela Wysocka, Izabella Rzad, Arleta Drozd, Jaroslaw Kuba
Turkish Journal of Biology
The aim of this study was to compare the activity of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and total and selenium-dependent glutathione peroxidase (total GSH-Px and Se-GSH-Px) in the liver of wild boars (Sus scrofa) selected from a selenium-deficient area with respect to season of the year, sex, and age. Only season had a significant effect on liver Se content. Liver selenium concentration in the wild boars was highest in spring (0.292 µg/g wet weight) and lowest in winter (0.185 µg/g wet weight) (P < 0.05). The highest mean activity of total GSH-Px, Se-GSH-Px, and CAT (404.0, 309.9, and 1170.0 U/mg protein, respectively) was found in the spring season, and the respective highest mean activity of SOD was found during autumn (31.5 U/mg protein). Females showed markedly higher mean activities of total GSH-Px (388.2 and 314.7 U/mg protein) and CAT (1151.0 and 765.8 U/mg protein) compared to males. In comparison to other groups of animals, those aged between 1 and 1.5 years were characterized by higher mean activity of total GSH-Px and Se-GSH-Px, and those over 2 years of age showed higher activity of CAT and SOD. The analysis showed that the strongest oxidative stress and the greatest risk of peroxidative damage to the liver occurred during the winter.
Microsatellites For Genetic And Taxonomic Research On Thyme (Thymus L.), Mehmet Karaca, Ayşe Gül İnce, Adnan Aydin, Safi̇naz Y. Elmasulu, Kenan Turgut
Microsatellites For Genetic And Taxonomic Research On Thyme (Thymus L.), Mehmet Karaca, Ayşe Gül İnce, Adnan Aydin, Safi̇naz Y. Elmasulu, Kenan Turgut
Turkish Journal of Biology
Microsatellites are considered the marker of choice in modern research. However, there is no application of microsatellites in the research on the genus Thymus due to the scarcity of specific primer pairs. Using in silico data of several genera in the family Lamiaceae, 23 microsatellite primer pairs (LT) were developed and evaluated in 48 samples representing 9 species and subspecies of the genus Thymus. Codominant and multiallelic LT microsatellite markers were not only useful in the determination of genetic structure and variation within and between the species but also were powerful taxonomic aids in the molecular phylogeny of Thymus L. …
A New Entomopathogenic Nematode Species From Turkey, Steinernema Websteri (Rhabditida: Steinernematidae), And Its Virulence, Ci̇han Gökçe, Zeynep Erbaş, Hüseyi̇n Yilmaz, Zi̇hni̇ Demi̇rbağ, İsmai̇l Demi̇r
A New Entomopathogenic Nematode Species From Turkey, Steinernema Websteri (Rhabditida: Steinernematidae), And Its Virulence, Ci̇han Gökçe, Zeynep Erbaş, Hüseyi̇n Yilmaz, Zi̇hni̇ Demi̇rbağ, İsmai̇l Demi̇r
Turkish Journal of Biology
Entomopathogenic nematodes were isolated from a population of larvae of the cutworm Agrotis segetum Denis & Schiffermüller, 1775 (Lepidoptera: Noctuidae) collected from the Black Sea region of Turkey in 2009 using White traps. The isolated nematodes were identified as Steinernema websteri based on morphological and molecular properties. Steinernema websteri was also found for the first time in Turkey and in A. segetum larvae. The efficacy of isolates was tested on A. segetum larvae in plastic boxes. Different concentrations of nematodes (100, 300, and 500 infective juveniles (IJs) g^{-1} of dry sand) at 23 ± 1 °C were used. The obtained …
A New Method For Segmentation Of Microscopic Images On Activated Sludge, Hali̇me Boztoprak, Yüksel Özbay
A New Method For Segmentation Of Microscopic Images On Activated Sludge, Hali̇me Boztoprak, Yüksel Özbay
Turkish Journal of Electrical Engineering and Computer Sciences
Activated sludge samples were taken from the Konya Wastewater Treatment Plant. Two hundred images for each sample were captured by a systematic examination of the slides. Segmentation of microscopic images is a challenging process due to lack of focus. Therefore, adjustment of the focus is required for every movement of the mobile stage. Because the mobile stage does not have the z axis, the focus cannot be adjusted. A new method that uses automatic segmentation of the captured images is developed for solving this problem. The proposed method is not dependent on image content, has minimal computation complexity, and is …
Dynamic Behavior Of A Second-Order Nonlinearrational Difference Equation, Yacine Halim, Nouressadat Touafek, Yasi̇n Yazlik
Dynamic Behavior Of A Second-Order Nonlinearrational Difference Equation, Yacine Halim, Nouressadat Touafek, Yasi̇n Yazlik
Turkish Journal of Mathematics
This paper deals with the global attractivity of positive solutions of the second-order nonlinear difference equation \begin{equation*} x_{n+1}=\frac{ax_{n}^{k}+b\displaystyle\sum_{j=1}^{k-1}x_{n}^{j}x_{n-1}^{k-j}+cx_{n-1} ^{k}}{Ax_{n}^{k}+B\displaystyle\sum_{j=1}^{k-1}x_{n}^{j}x_{n-1}^{k-j}+Cx_{n-1}^{k}},\ k=3,4,...,\,n=0,1,...,\label{eq1} \end{equation*} where the parameters $a$, $b$, $c$, $A$, $B$, $C$ and the initial values $x_{0}$, $x_{-1}$ are arbitrary positive real numbers.
Mutation Analysis Of 6 Spinocerebellar Ataxia (Sca) Types In Patients From Southern Turkey, Perçi̇n Pazarci, Hali̇l Kasap, Ayşe Fi̇li̇z Koç, Şaki̇r Altunbaşak, Mehmet Ali̇ Erkoç
Mutation Analysis Of 6 Spinocerebellar Ataxia (Sca) Types In Patients From Southern Turkey, Perçi̇n Pazarci, Hali̇l Kasap, Ayşe Fi̇li̇z Koç, Şaki̇r Altunbaşak, Mehmet Ali̇ Erkoç
Turkish Journal of Medical Sciences
Background/aim: Spinocerebellar ataxias (SCAs) are complex clinical and genetically heterogeneous, mostly autosomal dominant neurodegenerative diseases. At present, more than 30 hereditary SCA types have been associated with different gene mutations. In this study, the frequency distribution of the 6 SCA types 1, 2, 3, 6, 7, and 17 in the Turkish population was investigated with respect to clinical features. Materials and methods: 159 patients who received a diagnosis of SCA and 42 healthy controls from Adana, Mersin, Gaziantep, Hatay, and Osmaniye provinces were included in the study. DNA samples were isolated from 2 mL blood samples and the number of …
Paclitaxel-Loaded Niosomes For Intravenous Administration: Pharmacokineticsand Tissue Distribution In Rats, Zerri̇n Sezgi̇n Bayindir, Arzu Beşi̇kci̇, Ni̇lüfer Yüksel
Paclitaxel-Loaded Niosomes For Intravenous Administration: Pharmacokineticsand Tissue Distribution In Rats, Zerri̇n Sezgi̇n Bayindir, Arzu Beşi̇kci̇, Ni̇lüfer Yüksel
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. Materials and methods: Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for paclitaxel determination in rat plasma and tissues. Results: The area under the curve value of the niosome-recipient group (3.22 ± 0.255 μg h/mL) was significantly higher compared to that of the Taxol group (0.725 ± 0.163 μg h/mL). The mean residence time and the elimination …
Comparison Of Thiopental And Ketamine+Xylazine Anesthesia Inischemia/Reperfusion-Induced Arrhythmias In Rats, Ersöz Gonca
Comparison Of Thiopental And Ketamine+Xylazine Anesthesia Inischemia/Reperfusion-Induced Arrhythmias In Rats, Ersöz Gonca
Turkish Journal of Medical Sciences
Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the …
Bioimpedance For Assessing Volume Status In Children With Nephrotic Syndrome, Kadri̇ye Özdemi̇r, Makbule Sevgi̇ Mi̇r, Ni̇da Di̇nçel, Si̇bel Bozabali, İpek Kaplan Bulut, Ebru Yilmaz, Betül Sözeri̇
Bioimpedance For Assessing Volume Status In Children With Nephrotic Syndrome, Kadri̇ye Özdemi̇r, Makbule Sevgi̇ Mi̇r, Ni̇da Di̇nçel, Si̇bel Bozabali, İpek Kaplan Bulut, Ebru Yilmaz, Betül Sözeri̇
Turkish Journal of Medical Sciences
Background/aim: The effectiveness of assessing volume load via bioimpedance in pediatric patients with nephrotic syndrome (NS) was investigated. Materials and methods: Patients with NS (n = 34) were compared with healthy controls (n = 20). The inferior vena cava index and inferior vena cava collapsibility index (IVCCI) scores were determined for all subjects. Bioimpedance measurements were used to directly determine volume load. Clinical findings, relative fluid load, and echocardiographic measurements were determined and compared with bioimpedance in calculating volume load. Results: The sensitivity and specificity of bioimpedance in determining volume load were found to be 65% and 90%, respectively. IVCCI …
Prevention Of Methotrexate-Induced Nephrotoxicity By Concomitantadministration Of Garlic Aqueous Extract In Rat, Walaa Ahmed, Amr Zaki, Taghred Nabil
Prevention Of Methotrexate-Induced Nephrotoxicity By Concomitantadministration Of Garlic Aqueous Extract In Rat, Walaa Ahmed, Amr Zaki, Taghred Nabil
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX) has been widely used for treatment of cancer and rheumatoid arthritis, but its use has been limited by its nephrotoxicity. This study was carried out to determine whether garlic exerts a protective effect against MTX-induced nephrotoxicity. Materials and methods: Nephrotoxicity was induced in rats after a single i.p. injection of MTX (20 mg/kg). Garlic extract (1 mL/100 g b.w.) was given orally for 7 days before and after MTX administration. Serum samples were collected to evaluate urea, creatinine, sodium, phosphorous, potassium, and calcium. Reduced glutathione, catalase, adenosine deaminase, nitric oxide, and malondialdehyde were measured in renal tissue. …
The Expression Profile Of Aquaporin 1 In Rat Myocardium After Severe Burns, Wanli Li, Longying Zha, Zhiqing Li, Yuesheng Huang, Yiping Zhou
The Expression Profile Of Aquaporin 1 In Rat Myocardium After Severe Burns, Wanli Li, Longying Zha, Zhiqing Li, Yuesheng Huang, Yiping Zhou
Turkish Journal of Medical Sciences
Background/aim: To investigate the myocardial expression profile of aquaporin 1 (AQP1) in rats after severe burns. Materials and methods: Ninety healthy male adult Wistar rats were randomly assigned to the following treatments: sham operation (control group, n = 6), immediate fluid resuscitation treatment post scalding (IF group, n = 42), and delayed fluid resuscitation treatment after scalding (DF group, n = 42). At 3, 6, 12, 24, 48, 72, and 120 h after scalding, myocardial water contents were assayed and AQP1 expressions were detected by real-time polymerase chain reaction and western blot. The AQP levels in the myocardium at 12 …
Diagnostic And Prognostic Value Of Procalcitonin And Strem-1 Levels In Sepsis*, Hali̇m Bayram, Özlem Tünger, Melek Çi̇vi̇, Müni̇p Hakan Yüceyar, Cevval Ulman, Gönül Di̇nç Horasan, Çi̇ğdem Banu Çeti̇n
Diagnostic And Prognostic Value Of Procalcitonin And Strem-1 Levels In Sepsis*, Hali̇m Bayram, Özlem Tünger, Melek Çi̇vi̇, Müni̇p Hakan Yüceyar, Cevval Ulman, Gönül Di̇nç Horasan, Çi̇ğdem Banu Çeti̇n
Turkish Journal of Medical Sciences
Background/aim: Sepsis is still a major cause of morbidity and mortality despite the improvements in diagnosis and treatment. The aim of this study was to investigate the values of procalcitonin and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the differential diagnosis of patients with sepsis and noninfectious systemic inflammatory response syndrome (NI-SIRS) and measure their importance in the prognosis of patients with sepsis. Materials and methods: This prospective study included 41 NI-SIRS and 33 sepsis patients hospitalized in Celal Bayar University Hospital, Manisa, Turkey. Blood samples were taken from NI-SIRS patients on days 0 and 3 and from …
Correlation Between Antibiotic Resistance And Virulence Ofpseudomonas Aeruginosa Clinical Isolates, Fatma Ibrahim Sonbol, Maha Abd El Fattah Khalil, Abdelfattah Badr Mohamed, Sameh Samir Ali
Correlation Between Antibiotic Resistance And Virulence Ofpseudomonas Aeruginosa Clinical Isolates, Fatma Ibrahim Sonbol, Maha Abd El Fattah Khalil, Abdelfattah Badr Mohamed, Sameh Samir Ali
Turkish Journal of Medical Sciences
Background/aim: Virulent Pseudomonas aeruginosa is frequently life-threatening and often challenging to treat, and the emergence of multidrug-resistant isolates presents a critical problem for patients. The aim of the study was concerned with molecular analysis of the virulence factors and antimicrobial resistance profile of multidrug-resistant P. aeruginosa (MDRPA). Materials and methods: Out of 44 MDRPA isolates, 12 isolates representing different resistance profiles and sources of samples were selected for further molecular studies. Polymerase chain reaction (PCR) approaches were applied to identify the genes implicated in antimicrobial resistance or virulence factors in the selected MDRPA isolates. Results: Multidrug-resistance (pstS), ß-lactamase (IMP7, IMP10, …
Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş
Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg-1 day-1) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA …
In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün
In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün
Turkish Journal of Medical Sciences
Background/aim: Currently, the provision of blood products largely depends on walking blood banks and limited amounts of stored blood with short shelf lives. We aimed to compare the efficacy of erythrocyte concentrate (ECs) by pre- and postfreezing in vitro tests. Materials and methods: In our study, 10 ECs were glycerolized, frozen, thawed, and then deglycerolized using the Naval Blood Research Laboratory method. In addition to using the standard tests, ATP and 2,3-DPG levels and the viability of erythrocytes were also determined. Results: The prefreezing mean viability rates of erythrocytes changed from 89.7 ± 13.7% to 98.6 ± 1.8% after thawing …
Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi
Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to compare the cellular properties of endometrial tissues from fertile patients and patients having at least 3 previous in vitro fertilization failures, during the implantation window. The ultrastructural evaluation of the endometrium in the implantation window may shed light on the complexity of the implantation failure paradigm. Materials and methods: The study involved 23 women, 14 infertile with a clinical diagnosis of repeated implantation failure (RIF) and 9 fertile, defined as the control group. Endometrial samples were examined by transmission electron microscopy (TEM). Results: In the control group, secretory vacuoles and cytoplasmic projections …
Suspension Of Arthroderma And Trichophyton Species In Rpmi-1640medium Provided Long-Term Viability At Room Temperature, Çağri Ergi̇n, Mehmet Maci̇t İlki̇t
Suspension Of Arthroderma And Trichophyton Species In Rpmi-1640medium Provided Long-Term Viability At Room Temperature, Çağri Ergi̇n, Mehmet Maci̇t İlki̇t
Turkish Journal of Medical Sciences
No abstract provided.
Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer
Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer
Turkish Journal of Medical Sciences
Background/aim: Propolis is a bee product with antioxidative, antimutagenic, and other beneficial properties, and it is used as a natural drug. It is rich in polyphenolic compounds. Its composition varies depending on the particular geographical region. Oxidative stress is caused by an imbalanced free radical production and antioxidant system. The effects of flavonoids on the expression of DNA repair enzymes have been examined previously; however, no study has investigated the effects of propolis. This study investigated the effects of ethanolic extracts of Turkish propolis (EEP) on the expression of DNA repair enzymes. Materials and methods: The effects of EEP and …
Evaluation Of Gcf Mmp-1, Mmp-8, Tgf-Ss1, Pdgf-Ab, And Vegf Levels In Periodontally Healthy Smokers, Gülni̇hal Eren, Hati̇ce Oya Türkoğlu, Hari̇ka Atmaca, Fatma Gül Ati̇lla
Evaluation Of Gcf Mmp-1, Mmp-8, Tgf-Ss1, Pdgf-Ab, And Vegf Levels In Periodontally Healthy Smokers, Gülni̇hal Eren, Hati̇ce Oya Türkoğlu, Hari̇ka Atmaca, Fatma Gül Ati̇lla
Turkish Journal of Medical Sciences
Background/aim: The effect of smoking on inflammatory biomarkers in gingival crevicular fluid (GCF) is well established in the presence of periodontal inflammation. However, it is not clear if smoking has an influence on matrix metalloproteinase (MMP) and growth factor levels in the GCF of periodontally healthy subjects. The aim of this study was to investigate GCF levels of MMP-1, MMP-8, transforming growth factor (TGF)-ß1, platelet-derived growth factor (PDGF)-AB, and vascular endothelial growth factor (VEGF) in smoking versus nonsmoking periodontally healthy subjects. Materials and methods: Thirty-two periodontally healthy subjects were included in this study. Probing depths, bleeding on probing, and plaque …
A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi
A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi
Turkish Journal of Medical Sciences
Background/aim: House flies (Musca domestica) are of major public health concern in areas with poor sanitation and hygiene conditions. Biological control through the use of parasitoids and pathogens is one of the alternatives to the use of chemical pesticides for control of insects of public health importance. Materials and methods: The effects of the delta endotoxin of Bacillus thuringiensis on house fly larval mortality were studied. Gel filtration and SDS-PAGE methods were used for separation and purification of proteins. Delta endotoxin was incubated with larvae in concentrations of 0.43 mg/mL and 0.27 mg/mL in bioassay tests. Results: The results of …
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Turkish Journal of Medical Sciences
Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods: The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results: The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ …
Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Turkish Journal of Medical Sciences
Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL …
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Turkish Journal of Medical Sciences
Background/aim: Biofilm on urinary catheters results in persistent infections that are resistant to antibiotics. In this study, phytochemicals were assessed as alternative antimicrobials in preventing and inactivating E. coli biofilm on urinary catheters. Materials and methods: Biofilm prevention was tested using catheter fragments inoculated with E. coli and treated with trans-cinnamaldehyde, p-coumaric, and ferulic acids (0%, 0.1%, 0.25%, and 0.5%) for 0, 1, 3, and 5 days. Inactivation of E. coli biofilm with the same agents at concentrations of 0%, 1%, 1.25%, or 1.5% used for 0, 1, 3, or 5 days was also evaluated. Results: All used concentrations of …
Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇
Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇
Turkish Journal of Medical Sciences
Background/aim: To evaluate the periocular changes due to topical bimatoprost and latanoprost use and to investigate their effects on the lacrimal drainage system. Materials and methods: All participants (69 eyes of 43 patients, 52 eyes of 26 controls) were classified into three groups: bimatoprost (0.03%) users, latanoprost (0.005%) users, and healthy controls. Each patient was examined before prostaglandin therapy, and then at the first, third, sixth, and twelfth month of therapy. Palpebral fissure height, upper eyelid crease, and levator function were measured, and lacrimal system drainage irrigation was performed. Periocular hyperpigmentation and upper eyelid sulcus were also examined. Results: No …
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 …
Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi
Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi
Turkish Journal of Medical Sciences
Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in patients with dementia and to verify whether TNGFR can be used as a biomarker of dementia. Materials and methods: Twelve patients with dementia and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected …
A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci
A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic …
Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz
Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz
Turkish Journal of Medical Sciences
Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity. Materials and methods: Twenty-four Sprague-Dawley rats were divided equally into 3 experimental groups: sham group, APAP group, and APAP + 3-AB group. In the experimental treatment groups APAP was administered orally at 1 g/kg and, in the APAP + 3-AB group, 3-AB was administered intraperitoneally at a dose of 20 mg/kg exactly 1 …
Polymorphism Characteristics Of Hiv-1 Gp120 And 5 Hypervariable Regions, Neng Yao, Chunxia Zhang, Qi Liu, Jun Liu, Chiyu Zhang
Polymorphism Characteristics Of Hiv-1 Gp120 And 5 Hypervariable Regions, Neng Yao, Chunxia Zhang, Qi Liu, Jun Liu, Chiyu Zhang
Turkish Journal of Medical Sciences
To investigate polymorphism characteristics of HIV-1 gp120 and its 5 hypervariable regions. Materials and methods: Length polymorphism, potential number of N-linked glycosylation sites (PNGSs), and sequence characteristics of nearly all available global gp120 and its 5 hypervariable regions from HIV-1 subtypes A, B, C, D, G, and H were analyzed. Results: We found that the majority of HIV-1 gp120s have 496-515 amino acids and 21-30 PNGSs, suggesting that a gp120 with this length might be a good virus candidate for vaccine development. Among 5 hypervariable regions, the V3 regions had the lowest levels of length polymorphism and heterogeneity and less …