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Histochemistry Of Glandular Trichomes And The Structure Of Selected Organs Ofborago Officinalis L., Miroslawa Chwil, Andrzej Borowy
Histochemistry Of Glandular Trichomes And The Structure Of Selected Organs Ofborago Officinalis L., Miroslawa Chwil, Andrzej Borowy
Turkish Journal of Botany
In Poland, Borago officinalis is a cultivated plant or a segetal weed. It is a medicinal, cosmetic, melliferous, ornamental, and edible species. Its leaves, herb, flowers, and seeds are a source of bioactive compounds. Given the high concentration of essential fatty acids, borage is used in many branches of industry. The aim of this study was to examine the structure of trichomes and to carry out histochemical labeling of selected groups of biologically active compounds contained in secretory cells. Anatomical traits of leaves, stems, and pedicels were investigated using bright-field light, fluorescence, and scanning electron microscopy. Characteristic features of the …
Bioinformatics Prediction And Annotation Of Cherry (Prunus Avium L.) Micrornas And Their Targeted Proteins, Iftekhar Ahmed Baloch, Muhammad Younas Khan Barozai, Muhammad Din
Bioinformatics Prediction And Annotation Of Cherry (Prunus Avium L.) Micrornas And Their Targeted Proteins, Iftekhar Ahmed Baloch, Muhammad Younas Khan Barozai, Muhammad Din
Turkish Journal of Botany
MicroRNAs (miRNAs) are important noncoding regulatory RNAs. They are expressed endogenously and are 18-26 nucleotides in length. These small molecules are conserved evolutionarily within the same kingdom and their conserved nature becomes an important logical tool for the quest of conserved miRNAs in other species by homology search using bioinformatics tools. Cherry (Prunus avium L.) is one of the important and nutritious species of the family Rosaceae, mainly distributed in temperate climate. This research is an attempt to identify and characterize conserved miRNAs in cherry from express sequence tags (ESTs). Bioinformatics analysis of cherry ESTs resulted in the identification of …
Diversity And Functional Traits Of Spontaneous Plant Species In Algerian Rangelands Rehabilitated With Prickly Pear (Opuntia Ficus-Indica L.) Plantations, Souad Neffar, Taha Menasria, Haroun Chenchouni
Diversity And Functional Traits Of Spontaneous Plant Species In Algerian Rangelands Rehabilitated With Prickly Pear (Opuntia Ficus-Indica L.) Plantations, Souad Neffar, Taha Menasria, Haroun Chenchouni
Turkish Journal of Botany
The prickly pear (Opuntia ficus-indica L. Miller) is a xerophytic cactus species widely cultivated in arid and semiarid regions worldwide and used in rehabilitation programs of rangelands in Algeria since 1990. This study analyzed the diversity and functional traits of plant species established in prickly pear plantations growing under arid and semiarid climates. A 3-year plant assessment (2008-2010) was carried out using ecological descriptors (abundance, species richness, diversity indices, disturbance index, and Jaccard index) and plant functional traits (life forms, chorological types, dispersal types, Grime's, Noy-Meir's strategies, and morphological types). The results revealed 36 and 31 species in arid and …
Systematics Value Of Micromorphological And Palynological Characters In Stenocephalum Sch.Bip. (Vernonieae, Asteraceae), Maria Betiana Angulo, Laura Chalup, Massimiliano Dematteis
Systematics Value Of Micromorphological And Palynological Characters In Stenocephalum Sch.Bip. (Vernonieae, Asteraceae), Maria Betiana Angulo, Laura Chalup, Massimiliano Dematteis
Turkish Journal of Botany
Micromorphological and palynological characters of all Stenocephalum Sch.Bip. species (Vernonieae, Asteraceae) were analyzed to evaluate their reliability as taxonomic markers at generic level and discussed in relation to other genera of the subtribe Lepidaploinae. Characters such as pubescence of corollas and cypselae showed glandular and nonglandular trichomes allowing differentiation among related species. Apical appendages without glandular trichomes, caudate anthers, and carpopodium structure are common characteristics among Stenocephalum species. With the exceptions of S. megapotamicum and S. tragiaefolium, almost all species of the genus showed style bases without basal nodes for the first time. Crystals on the fruits wall were also …
New Records And Rare Taxa For The Freshwater Algae Of Turkeyfrom The Tatar Dam Reservoir (Elazığ), Memet Varol, Saul Blanco, Kenan Alpaslan, Gökhan Karakaya
New Records And Rare Taxa For The Freshwater Algae Of Turkeyfrom The Tatar Dam Reservoir (Elazığ), Memet Varol, Saul Blanco, Kenan Alpaslan, Gökhan Karakaya
Turkish Journal of Botany
Recently, the number of algological studies in Turkish inland waters has increased remarkably. However, taxonomic and floristic studies on algae in the Euphrates basin are still scarce. This study contributes new information to the knowledge of the Turkish freshwater algal flora. Phytoplankton samples were collected from the Tatar Dam Reservoir in the Euphrates Basin between January 2016 and December 2016. Two taxa were recorded for first time and 14 rare taxa for the freshwater algae of Turkey were identified in this study. The new records belong to the phylum Bacillariophyta, whereas taxa considered as rare belong to the phyla Chlorophyta, …
New Cytological, Morphological, And Chorological Data On Prospero Seisumsianum(Ruk?Ans & Zetterl.) Yıldırım (Asparagaceae) From The Zagros Area, Sami Youssef, Ahmed Mahmood, Manuel Cartereau, Errol Vela
New Cytological, Morphological, And Chorological Data On Prospero Seisumsianum(Ruk?Ans & Zetterl.) Yıldırım (Asparagaceae) From The Zagros Area, Sami Youssef, Ahmed Mahmood, Manuel Cartereau, Errol Vela
Turkish Journal of Botany
Prospero seisumsianum (Ruk?ans & Zetterl.) Yıldırım, a species recently described in southeastern Turkey, was recorded for the first time in the flora of Iraq based on samples collected from the Amadya and Duhok areas (northern Iraq). Our contribution here will be to find out more about its description, cytology, and chorology. The specimen collected from the Mesopotamian dry plain differs slightly from those collected from the mountainous Zagros forest area, but converges after a cultivation period. Both are treated here as P. seisumsianum and have the same genome size (2C = 8.77 ± 0.24 pg) corresponding to a diploid level. …
Seed Structure And Its Taxonomic Implications For Genus Thlaspi Sensu Lato Sectionsnomisma, Thlaspi, And Pterotropis (Brassicaceae), Mehmet Cengi̇z Karai̇smai̇loğlu, Osman Erol
Seed Structure And Its Taxonomic Implications For Genus Thlaspi Sensu Lato Sectionsnomisma, Thlaspi, And Pterotropis (Brassicaceae), Mehmet Cengi̇z Karai̇smai̇loğlu, Osman Erol
Turkish Journal of Botany
We studied morphological and anatomical characteristics of seeds of 22 taxa in the sections Nomisma, Thlaspi, and Pterotropis of Thlaspi sensu lato from Turkey and the significance of these characters in a taxonomical context. The results show that the taxa differ from each other in terms of seed shape and color. The seed size ranges from 1.25 mm to 2.99 mm in length and from 0.66 mm to 2.16 mm in width, Thlaspi rosulare and T. tatianae having the largest and T. annuum having the smallest seeds. The seed surface ornamentation is classified into nine types: reticulate-areolate, scalariform, reticulate, reticulate-foveate, …
Two New Malagasy Species Of Genus Piper L. (Piperaceae), Piper Malgassicum And Piper Tsarasotrae, And Their Phylogenetic Position, Enrico Palchetti, Stefano Biricolti, Massimo Gori, Giulia Rota Nodari, Nicola Gandolfi, Alessio Papini
Two New Malagasy Species Of Genus Piper L. (Piperaceae), Piper Malgassicum And Piper Tsarasotrae, And Their Phylogenetic Position, Enrico Palchetti, Stefano Biricolti, Massimo Gori, Giulia Rota Nodari, Nicola Gandolfi, Alessio Papini
Turkish Journal of Botany
Here we describe two new species of genus Piper L. from Madagascar: Piper malgassicum and Piper tsarasotrae, the species names referring to the currently known distribution areas. These two species contribute, at least in part, to the production of local voatsiperifery pepper, probably mixed together with P. borbonense, and are therefore economically relevant as spices. We used a selected set of characters (those more easily observable on herbarium samples) for principal component analysis to assess the relative distance between the species, including the analysis of the autochthonous species of Piper known from Africa and Madagascar. In order to check the …
New Contributions To The Turkish Ascomycota, Abdullah Kaya, Yasi̇n Uzun
New Contributions To The Turkish Ascomycota, Abdullah Kaya, Yasi̇n Uzun
Turkish Journal of Botany
Nine discomycete and one sordariomycete (Ascomycota) species are reported for the first time from Turkey. The genera Coccomyces, Kompsoscypha, Pseudopithyella, Strobiloscypha, and Lasiosphaeris have not been reported before in the country. Anthracobia, Plicaria, Sclerotinia, and Pithya species are new records added to the previous knowledge. Macro- and micromorphological descriptions and illustrations for each new taxon are provided.
Gamma Irradiation Enhancement Of Biofilm Production In Bacillus Amyloliquifaciensand Effect Of Mutants' Inoculation On Apx1 Expression In Salt-Stressed Egyptian Barley, Reda Gaafar, Wedad Kasim, Rania Abou-Ali, Mohamed Omar, Heba Hewait
Gamma Irradiation Enhancement Of Biofilm Production In Bacillus Amyloliquifaciensand Effect Of Mutants' Inoculation On Apx1 Expression In Salt-Stressed Egyptian Barley, Reda Gaafar, Wedad Kasim, Rania Abou-Ali, Mohamed Omar, Heba Hewait
Turkish Journal of Botany
Gamma rays are known to induce random mutations, which are used to enhance the production of biofilms in bacteria. Therefore, to improve the activity of biofilm formation in wild Bacillus amyloliquefaciens (HM6), this bacterial strain was mutated using five doses of gamma irradiation. Sixteen mutants and their wild strain B. amyloliquefaciens (HM6) were tested for biofilm formation under two different (250 and 350 mM) NaCl concentrations. Only six mutants exhibited a significant increase in biofilm formation under 350 mM NaCl. Inoculation of salt-stressed Giza123 barley seedlings with the two mutants (M1 and M7), which showed distinguishable rep-PCR patterns, and their …
Analysis Of Airborne Pollen Of Gümüşhane Province In Northeastern Turkey And Its Relationship With Meteorological Parameters, Yavuz Türkmen, Tali̇p Çeter, Nur Münevver Pinar
Analysis Of Airborne Pollen Of Gümüşhane Province In Northeastern Turkey And Its Relationship With Meteorological Parameters, Yavuz Türkmen, Tali̇p Çeter, Nur Münevver Pinar
Turkish Journal of Botany
Knowledge of the types of atmospheric pollen and their concentrations in a particular area is critical for evaluating air quality and allergen exposure. This study was carried out to determine the pollen diversity and daily, monthly, and annual concentrations in Gümüşhane, whose relationships were then sought with the meteorological factors in the atmosphere of Gümüşhane. For this purpose, an aerobiological study was carried out with Hirst (Burkard) type pollen traps in the Gümüşhane city center between August 2010 and July 2012. Sampling and analysis of the pollens followed the method described by the Spanish Aerobiological Network. The duration of the …
Moscow Digital Herbarium, An Online Open Access Contribution To The Flora Of Turkey,With A Special Reference To The Type Specimens, Alexey P. Seregin, Dmitry F. Lyskov, Ksenia V. Dudova
Moscow Digital Herbarium, An Online Open Access Contribution To The Flora Of Turkey,With A Special Reference To The Type Specimens, Alexey P. Seregin, Dmitry F. Lyskov, Ksenia V. Dudova
Turkish Journal of Botany
Massive imaging of herbarium collections is performed only in a few countries, leading to disproportions in geographical coverage of the world's flora across virtual herbaria. The Moscow University Herbarium (MW) digitised all Asian collections in 2016-2017 and published them online at https://plant.depo.msu.ru/, including 3283 specimens from Turkey. These collections include important historical gatherings by P.E. Boissier, C. Haussknecht, and T. Kotschy and recent collections by the Moscow University staff members. Currently, MW holds 331 type specimens of 285 taxa described from Anatolia-19 holotypes, 47 isotypes, 48 isolectotypes, and 203 syntypes.
Hybrid Organic Molecules As Antiinammatory Agents; A Review Of Structuralfeatures And Biological Activity, Noor Ul Amin Mohsin, Matloob Ahmad
Hybrid Organic Molecules As Antiinammatory Agents; A Review Of Structuralfeatures And Biological Activity, Noor Ul Amin Mohsin, Matloob Ahmad
Turkish Journal of Chemistry
Nonsteroidal antiin ammatory drugs (NSAIDs) are widely used for the treatment of pain and in ammation. Some undesirable effects are linked with NSAIDs such as the gastrointestinal tract (GIT) toxicity and cardiovascular disturbances. At present the preparation of a hybrid molecular technique is being used to produce new analgesic and antiin ammatory molecules. Attachment of NSAIDs with nitric oxide and hydrogen sulfide releasing molecules produced some gastroprotective agents with improved analgesic and antiinflammatory activities. Combination of NSAIDs with different biologically active 5-membered, 6-membered, and condensed heterocyclic rings has also led to the formation of some potent molecules. Some of these …
Facile Synthesis Of Heteroaryl Substituted -Lactams From Nitrovinyl Arenes, Seda Çinar, Canan Ünaleroğlu
Facile Synthesis Of Heteroaryl Substituted -Lactams From Nitrovinyl Arenes, Seda Çinar, Canan Ünaleroğlu
Turkish Journal of Chemistry
Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted γ-lactams in good to high yields under mild reaction conditions.
Synthesis And Antioxidant, Aggregation, And Electronic Properties Of6-Tert-Butyl-1,4-Benzodioxine Substituted Phthalocyanines, Mehmet Sali̇h Ağirtaş, Beyza Cabi̇r, Selçuk Gümüş, Sadi̇n Özdemi̇r, Abdurrahman Dündar
Synthesis And Antioxidant, Aggregation, And Electronic Properties Of6-Tert-Butyl-1,4-Benzodioxine Substituted Phthalocyanines, Mehmet Sali̇h Ağirtaş, Beyza Cabi̇r, Selçuk Gümüş, Sadi̇n Özdemi̇r, Abdurrahman Dündar
Turkish Journal of Chemistry
As a starting material, 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile was prepared by the reac- tion of 4-tert-butylcatechol with 4,5-dichlorophthalonitrile. Metallophthalocyanine complexes 4-7 were obtained by cyclotetramerization of 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile. All compounds were characterized by elemental analysis and other spectroscopic methods (IR, UV/Vis, and $^{1}$H NMR). Phthalocyanine compounds remained nonaggregated in tetrahydrofuran at the studied concentration ranges. Metallophthalocyanines 4-7 were tested for their antioxidant activities. The antioxidant activity processes included evaluation of radical-scavenging activity, chelat- ing activity, and reducing power. These compounds were compared to standard antioxidant ascorbic acid. The electronic data of the new compounds were obtained by computational …
Biological Study On Novel Coumarinyl 1,3,4-Oxadiazoles, Maja Molnar, Ana Amic, Valentina Pavic, Tihomir Kovac, Marija Kovac, Elizabeta Has-Schön
Biological Study On Novel Coumarinyl 1,3,4-Oxadiazoles, Maja Molnar, Ana Amic, Valentina Pavic, Tihomir Kovac, Marija Kovac, Elizabeta Has-Schön
Turkish Journal of Chemistry
Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures confirmed by mass and $^{1}$H and $^{13}$C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, anta atoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)- 2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,4-phenylene diacetate showed significant antioxidant and antibacterial activity on B. subtilis. 4-(3-Acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,2-phenylene diacetate was found to possess excellent antifungal and antia atoxigenic activity.
The Synthesis Of New Oxindoles As Analogs Of Natural Product 3,3$^\Prime $-Bis(Indolyl)Oxindole And In Vitro Evaluation Of The Enzyme Activity Of G6pd And 6pgd, Si̇nan Bayindir, Adnan Ayna, Yusuf Temel, Mehmet Çi̇ftci̇
The Synthesis Of New Oxindoles As Analogs Of Natural Product 3,3$^\Prime $-Bis(Indolyl)Oxindole And In Vitro Evaluation Of The Enzyme Activity Of G6pd And 6pgd, Si̇nan Bayindir, Adnan Ayna, Yusuf Temel, Mehmet Çi̇ftci̇
Turkish Journal of Chemistry
Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new oxindoles with reaction of 4,7-dihydro-1$H$-indole (2) and isatin (4) were synthesized as analogs of natural product 3,3$^\prime $-bis(indolyl)oxindole. The biological properties of the compounds obtained during this study were also studied, showing that compounds 5, 7, and 12 inhibited the activity of G6PD with an IC$_{50}$ of 99 $\mu $M, 231 $\mu $M, and 304 $\mu $M respectively. The activity of rat …
Development Of A Molecularly Imprinted Polymer-Based Electrochemical Sensor For Tyrosinase, Aysu Yarman
Development Of A Molecularly Imprinted Polymer-Based Electrochemical Sensor For Tyrosinase, Aysu Yarman
Turkish Journal of Chemistry
For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from mushrooms, which has a high homology to the human enzyme. The template was removed either by treatment with proteinase K or by alkaline treatment. The measuring signal was generated either by measuring the formation of a product by the target enzyme or by evaluation of the permeability of the redox marker ferricyanide. The o-phenylenediamine-based MIP sensor has a linear measuring range up to 50 nM of tyrosinase with a …
Protein Ion-Exchange Chromatography On A Biomacromolecule-Immobilized Monolithic Cryogel, Ahmet Eren Özkan, Idris Guven, Orhan Gezici
Protein Ion-Exchange Chromatography On A Biomacromolecule-Immobilized Monolithic Cryogel, Ahmet Eren Özkan, Idris Guven, Orhan Gezici
Turkish Journal of Chemistry
An efficient and inexpensive monolithic stationary phase (PHEMA-HA) has been prepared through an easy process comprising addition of humic acid (HA) to a mixture of 2-hydroxyethyl methacrylate (HEMA) and N,N'-methylenebisacrylamide (MBAAm) and subsequent radical-polymerization at -20 $^{\circ}$C. The prepared monolithic material was characterized in terms of various techniques and methods such as elemental analysis, FTIR spectroscopy, scanning electron microscopy, mercury porosimetry, hydrolytic stability tests, pH$_{pzc}$ measurements, water-holding capacity, and water permeability. The amount of HA incorporated into the structure was calculated as 45 mg/g from the elemental analysis results. The study was conceptualized on the basis of protein ion-exchange chromatography, …
Nickel(Ii)-Pph$_{3}$ Complexes With Ons And Onn Chelating Thiosemicarbazones: Synthesis And Inhibition Potential On Influenza A Viruses, Şükri̇ye Güveli̇, Kadi̇r Turan, Bahri̇ Ülküseven
Nickel(Ii)-Pph$_{3}$ Complexes With Ons And Onn Chelating Thiosemicarbazones: Synthesis And Inhibition Potential On Influenza A Viruses, Şükri̇ye Güveli̇, Kadi̇r Turan, Bahri̇ Ülküseven
Turkish Journal of Chemistry
Tetra-coordinated nickel(II) complexes of two ONS (1, \2) and seven ONN (3a-3g) chelating 2-hydroxy-3-methoxy-benzaldehyde thiosemicarbazones were synthesized. The dibasic ligands and complexes bearing PPh$_{3}$ as a coligand were characterized by means of analytical and spectroscopic data. Cytotoxic activities of the ligands and nickel(II) complexes were determined using the MTT assay in vitro against MDCK cells, and then all the compounds were tested on influenza virus replication by plaque assays. The compounds showed GI$_{50}$ values varying from concentrations of 15.9 up to 161.8 $\mu$ g/mL for MDCK cells. The plaque assays indicated that one ONS (1) and two ONN (3c and …
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Turkish Journal of Chemistry
The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4$H$-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.
Synthesis And Biological Evaluation Of Novel Chalcones Bearing Morpholine Moiety As Antiproliferative Agents, Bedri̇ye Seda Kurşun Aktar, Emi̇ne Elçi̇n Oruç-Emre, İbrahi̇m Demi̇rtaş, Ayşe Şahi̇n Yağlioğlu, Ayşegül Karaküçük İyi̇doğan, Çağlar Güler, Şevki̇ Adem
Synthesis And Biological Evaluation Of Novel Chalcones Bearing Morpholine Moiety As Antiproliferative Agents, Bedri̇ye Seda Kurşun Aktar, Emi̇ne Elçi̇n Oruç-Emre, İbrahi̇m Demi̇rtaş, Ayşe Şahi̇n Yağlioğlu, Ayşegül Karaküçük İyi̇doğan, Çağlar Güler, Şevki̇ Adem
Turkish Journal of Chemistry
In this research, a new series of ($E)$-3-(4-substitutedphenyl)-1-(4'-morpholinophenyl)prop-2-en-1-one derivatives 1-7 was synthesized, aiming to develop effective antiproliferative agents. The antiproliferative activities of compounds 1-7 were examined against HeLa and C6 cell lines at eight different concentrations using the BrdU ELISA assay. The activity results were compared with reference anticancer drug 5-fluorouracil (5-FU). Compound 1 had almost the same antiproliferative activity as 5-FU. Compounds 1-7 were found to have greater effects against the C6 cell line than the HeLa cell line. These compounds were also tested in order to determine their effects on enzyme activities. Compounds 2 and 3 exhibited strong …
Multiwall Carbon Nanotube Paste Electrode As A Sensor For Sensitive Determination Of Deferasirox In The Presence Of Uric Acid: Application For The Analysis Of Pharmaceutical And Biological Samples, Golnaz Parvizi Fard, Reza Emamali Sabzi
Multiwall Carbon Nanotube Paste Electrode As A Sensor For Sensitive Determination Of Deferasirox In The Presence Of Uric Acid: Application For The Analysis Of Pharmaceutical And Biological Samples, Golnaz Parvizi Fard, Reza Emamali Sabzi
Turkish Journal of Chemistry
In this work, the electrochemical oxidation of deferasirox at a multiwall carbon nanotube paste electrode (MWCNTPE) was described. The electrochemical behavior of deferasirox was studied using cyclic voltammetry and chronoamperometry techniques and parameters such as charge transfer coefficient ($\alpha )$, the number of electrons involved in the rate-determining step ($n_{a})$, and diffusion coefficient ($D)$ were calculated. The capability of the electrode for the determination of deferasirox at low concentrations was investigated using the differential pulse voltammetry technique. It was found that the calibration graph of deferasirox was linear in the concentration range of 0.16-16.5 $\mu $M and its detection limit …
Biological Evaluation And Synthesis Of New Pyrimidine-2(1h)-Ol/-Thiol Derivatives Derived From Chalcones Using The Solid Phase Microwave Method, Seda Fandakli, Nuran Kahri̇man, Tayyi̇be Beyza Yücel, Şengül Alpay Karaoğlu, Nuretti̇n Yayli
Biological Evaluation And Synthesis Of New Pyrimidine-2(1h)-Ol/-Thiol Derivatives Derived From Chalcones Using The Solid Phase Microwave Method, Seda Fandakli, Nuran Kahri̇man, Tayyi̇be Beyza Yücel, Şengül Alpay Karaoğlu, Nuretti̇n Yayli
Turkish Journal of Chemistry
Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20-34) and 4,6-diarylpyri\-midine-2(1H)-thiol derivatives (35-44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1-one compounds (1-19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20-44) were evaluated with regard to their $\alpha $-glucosidase activity. However, only compounds 22-25, 27,31,34, 35,37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC$_{50}$ values of the active compounds ranged between 2.36 and 13.34 $\mu $M. The 25 new compounds were also screened for their in vitro pancreatic lipase activity and compounds 20-27and 35-39 were found to be active. Of …
Recent Advances In Organ-On-A-Chip Technologies And Future Challenges: A Review, Hüseyi̇n Avci, Fatma Doğan Güzel, Sali̇m Erol, Ali̇ Akpek
Recent Advances In Organ-On-A-Chip Technologies And Future Challenges: A Review, Hüseyi̇n Avci, Fatma Doğan Güzel, Sali̇m Erol, Ali̇ Akpek
Turkish Journal of Chemistry
The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of `organ-on-a-chip' systems. Organ-on-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development. Only about 1 out of 10,000 compounds is processed in clinical trials for final approval. As being the first example of its kind, …
Schiff Base Of Isoniazid And Ketoprofen: Synthesis, X-Ray Crystallographic, Spectroscopic, Antioxidant, And Computational Studies, Naima Rehman, Muhammad Khalid, Moazzam Hussain Bhatti, Uzma Yunus, Ataualpa Albert Carmo Braga, Faiz Ahmed, Syed Muddassir Ali Mashhadi, Muhammad Nawaz Tahir
Schiff Base Of Isoniazid And Ketoprofen: Synthesis, X-Ray Crystallographic, Spectroscopic, Antioxidant, And Computational Studies, Naima Rehman, Muhammad Khalid, Moazzam Hussain Bhatti, Uzma Yunus, Ataualpa Albert Carmo Braga, Faiz Ahmed, Syed Muddassir Ali Mashhadi, Muhammad Nawaz Tahir
Turkish Journal of Chemistry
Ketoprofen and isoniazid together are a potential combination of a nonsteroidal antiinflammatory drug and an antitubercular medicine to treat tuberculosis and associated symptoms like fever and fatigue. The Schiff base of isoniazid with ketoprofen is synthesized in this research. Infrared spectroscopy (IR) and X-ray diffraction (XRD) analysis of the crystal packing proved the formation of the Schiff base and the existence of N-H$\cdot \cdot \cdot $O hydrogen bonds between the hydrogen-bonded dimer of the Schiff base. The complete geometrical optimization of the monomer and hydrogen-bonded dimer of the Schiff base is performed utilizing M06-2X/6-31G(d,p) level theory and compared with the …
$S$-Substituted Derivatives Of 1,2,4-Triazol-3-Thiol As New Drug Candidates For Type Ii Diabetes, Aziz Ur Rehman, Khadija Nafeesa, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Syed Adnan Ali Shah, Muhammad Ashraf, Muhammad Arif Lodhi, Farman Ali Khan, Bakht Jahan
$S$-Substituted Derivatives Of 1,2,4-Triazol-3-Thiol As New Drug Candidates For Type Ii Diabetes, Aziz Ur Rehman, Khadija Nafeesa, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Syed Adnan Ali Shah, Muhammad Ashraf, Muhammad Arif Lodhi, Farman Ali Khan, Bakht Jahan
Turkish Journal of Chemistry
The therapeutic applications of 1,2,4-triazoles motivated us to synthesize some new derivatives. Two series of $S$-substituted derivatives (8a-8j, 12a-12i) of 5-$\{$1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl$\}$-4-phenyl-4$H$-1,2,4-triazol-3-thiol (6) have been synthesized and evaluated for their biological potential. Using 4-chlorobenzene sulfonyl chloride (1) and ethyl piperidine-3-carboxylate (2), ethyl 1-[(4-chlorophenyl)sulfonyl]piperidine-3-carboxylate (3) was synthesized and converted into 3,4,5-trisubstituted 1,2,4-triazole (6) through formation of the corresponding carbohydrazide (4) and hydrazinecarbothioamide (5). Compound 6 was transformed into 8a-8j by alkyl halides (7a-7j) and into 12a-12i by $N$-aralkyl/aryl-2-bromoacetamides (11a-11i) in an aprotic solvent. The electrophiles, 11a-11i, were synthesized by gearing up $N$-substituted aralkyl/aryl amines (10a-10i) with 2-bromoacetyl bromide (9) under dynamic pH …
Synthesis Of Some Ketones Via Nano-Nickel Oxide Catalyzed Acylation Of Arylzinc Reagents; Strategy Involving The Use Of Mixed (Methyl)(Aryl)Zincs, Özgen Ömür Pekel, Ender Erdi̇k, Meli̇ke Kalkan
Synthesis Of Some Ketones Via Nano-Nickel Oxide Catalyzed Acylation Of Arylzinc Reagents; Strategy Involving The Use Of Mixed (Methyl)(Aryl)Zincs, Özgen Ömür Pekel, Ender Erdi̇k, Meli̇ke Kalkan
Turkish Journal of Chemistry
Nano-NiO catalyzed acylation of mixed (methyl)(aryl)zincs with aromatic acyl halides in THF at room temperature provides a new facile route for aryl-aroyl coupling. Among NiCl$_{2}$.L$_{2}$ and NiCl$_{2}$.L (L = monodentate and bidentate phosphine ligand) catalysts, the lower catalyst loading of NiCl$_{2}$ (dppf) may seem attractive; however, nano-NiO, being the lowest cost catalyst, is more favorable for aroylation of (methyl)(aryl)zincs. This procedure also provides a supplement to Cu and Pd catalyzed acylation of diorganozincs.
Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators, İsmai̇l Kayaği̇l, Ayşe Gül Mutlu, Ülkü Bayhan, İnanç Yilmaz, Şeref Demi̇rayak
Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators, İsmai̇l Kayaği̇l, Ayşe Gül Mutlu, Ülkü Bayhan, İnanç Yilmaz, Şeref Demi̇rayak
Turkish Journal of Chemistry
Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to give the thiazole derivatives (1, 2). The two ethyl thiazole-carboxylate derivatives (1, 2) thus obtained were treated with sodium hydroxide solution and ethanol and converted to carboxylic acids (3, 4). The carboxylic acid derivatives (3, 4) were reacted with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine derivatives (5, 6) were obtained. These two derivatives (5, 6) were converted into two chloroacetamidothiadiazole derivatives (7, 8) by reaction with …
Synthesis, Solvatochromism, And Biological Activity Of Novel Azo Dyes Bearing 2-Pyridone And Benzimidazole Moieties, Dusan Mijin, Biljana Bozic Nedeljkovic, Bojan Bozic, Ilijana Kovrlija, Jelena Ladarevic, Gordana Uscumlic
Synthesis, Solvatochromism, And Biological Activity Of Novel Azo Dyes Bearing 2-Pyridone And Benzimidazole Moieties, Dusan Mijin, Biljana Bozic Nedeljkovic, Bojan Bozic, Ilijana Kovrlija, Jelena Ladarevic, Gordana Uscumlic
Turkish Journal of Chemistry
New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and $^{1}$H and $^{13}$C NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed. An MTT (3,4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test was performed to prove the biocompatibility of the investigated dyes. The investigated dyes exhibited satisfying antiproliferative activities against both tumor cell lines, MDA-MB-231 …