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Ubiquitin-Specific Protease 7 Downregulation Suppresses Breast Cancer In Vitro, Taha Bartu Hayal, Ayşegül Doğan, Hati̇ce Burcu Şi̇şli̇, Bi̇nnur Kiratli, Fi̇kretti̇n Şahi̇n
Ubiquitin-Specific Protease 7 Downregulation Suppresses Breast Cancer In Vitro, Taha Bartu Hayal, Ayşegül Doğan, Hati̇ce Burcu Şi̇şli̇, Bi̇nnur Kiratli, Fi̇kretti̇n Şahi̇n
Turkish Journal of Biology
Because breast cancer is complicated at the pathological, histological, clinical, and molecular levels, identification of new genetic targets against carcinogenic pathways is required to generate clinically relevant treatment options. In the current study, ubiquitinspecific protease 7 (USP7), which regulates various cellular pathways including Mdm2, p53, and NFκB, was selected as a potential gene editing strategy for breast cancer in vitro. Anticancer activity of USP7 gene suppression has been evaluated through cell proliferation, gene expression, cell cycle, sphere dissemination, and cell migration analysis. Here, siRNA and shRNA strategies and an allosteric small-molecule inhibitor of USP7 were used to define potential anticancer …
Akt-Mediated Phosphorylation Of Twist1 Is Essential For Breast Cancer Cell Metastasis, Mustafa Gökhan Ertosun, Suray Pehli̇vanoğlu, Sayra Di̇lmaç, Gamze Tanriöver, Osman Ni̇dai̇ Özeş
Akt-Mediated Phosphorylation Of Twist1 Is Essential For Breast Cancer Cell Metastasis, Mustafa Gökhan Ertosun, Suray Pehli̇vanoğlu, Sayra Di̇lmaç, Gamze Tanriöver, Osman Ni̇dai̇ Özeş
Turkish Journal of Biology
Previously, it was shown that human TWIST1 (basic helix-loop-helix (b-HLH) is phosphorylated by Akt kinase at S42, T121, and S123. To show in vivo effect of these phosphorylations, we created mouse TWIST1 expression vector and converted the codons of S42, T125, and S127 to unphosphorylatable alanine and phosphorylation mimicking Glutamic acid. We hypothesized that alanine mutants would inhibit the metastatic ability of 4T1 cells while glutamic acid mutants would convert nonmetastatic 67NR cells into metastatic phenotype. To confirm this hypothesis, we created metastatic 4T1 and nonmetastatic 67NR cells expressing alanine mutants and glutamic acid mutants mouse TWIST1, respectively. Then, we …
Simultaneous Production Of Alpha And Beta Amylase Enzymes Using Separate Gene Bearing Recombinant Vectors In The Same Escherichia Coli Cells, Di̇lek Özcan Yardim, Hi̇kmet Murat Si̇pahi̇oğlu
Simultaneous Production Of Alpha And Beta Amylase Enzymes Using Separate Gene Bearing Recombinant Vectors In The Same Escherichia Coli Cells, Di̇lek Özcan Yardim, Hi̇kmet Murat Si̇pahi̇oğlu
Turkish Journal of Biology
The present study describes the simultaneous expression of thermostable industrial alpha (α) and beta (ß) amylase enzymes that have been used widely in starch industry. Genomic DNA of Bacillus stearothermophilus DSM 22 strain for α amylase and, Thermoanaerobacterium (Clostridium) thermosulfurogenes DSM 2229 strain for ß amylase were used as gene sources. Both genes were ligated into pETDuet-1 expression vector separately and resulting recombinant vectors were transformed into Escherichia coli BL21 competent cells by electroporation. The cells were first transformed by pETDuet-1/ αAmy recombinant plasmid, then the competent cells carrying this plasmid were prepared for the transformation of pETDuet-1/ ßAmy plasmid. …
Prediction, Isolation, Overexpression And Antifungal Activity Analysis Of Medicago Truncatula Var. Truncatula Putative Thaumatin Like Proteins (Tlp-1, -2, -3, -4 And -5), Maryam Saeidi, Reza Zareie
Prediction, Isolation, Overexpression And Antifungal Activity Analysis Of Medicago Truncatula Var. Truncatula Putative Thaumatin Like Proteins (Tlp-1, -2, -3, -4 And -5), Maryam Saeidi, Reza Zareie
Turkish Journal of Biology
Pathogenesis-related proteins (PR-proteins) are induced in response to environmental stresses such as osmotic and drought stress, wounding, microbial infections and treatment with specific plant hormones and elicitors. These proteins are classified into several groups (PR-1 through PR-17) based on their amino acid sequence and biochemical functions. The present study focuses on prediction, isolation, over-expression and analysis of the antifungal activities of the thaumatin-like proteins (i.e. PR-5) in the model legume M. truncatula var. truncatula. Analysis of M. truncatula genome sequence, available freely on the NCBI website, indicated the presence of at least 15 PR-5 Open Reading Frames (ORFs), 5 of …
The Effects Of Harvesting Time On The Physicochemical Components Of Aronia Berry, Sevgi̇ Poyraz Engi̇n, Cevri̇ye Mert
The Effects Of Harvesting Time On The Physicochemical Components Of Aronia Berry, Sevgi̇ Poyraz Engi̇n, Cevri̇ye Mert
Turkish Journal of Agriculture and Forestry
The aim of this work was to compare 'Nero' and 'Viking' aronia cultivars and to determine the optimum harvest dates of each cultivar for various utilizations. For this purpose, we characterized the changes in both aronia cultivars' physicochemical components over their harvest period and identified the correlations between them. Mean berry weight, dry matter, soluble solid content, antioxidant activity, and anthocyanin content of berries of both cultivars increased until the second and third weeks of September. They then began decreasing gradually, whereas total phenol content and condensed tannins kept increasing until 27 October. It was observed that berries of 'Nero' …
Variety Differences In Garlic Volatile Sulfur Compounds, By Application Of Selected Ion Flow Tube Mass Spectrometry (Sift-Ms) With Chemometrics, Gülşah Özcan Si̇ni̇r, Sheryl Ann Barringer
Variety Differences In Garlic Volatile Sulfur Compounds, By Application Of Selected Ion Flow Tube Mass Spectrometry (Sift-Ms) With Chemometrics, Gülşah Özcan Si̇ni̇r, Sheryl Ann Barringer
Turkish Journal of Agriculture and Forestry
Garlic releases a strong odor after tissue disruption by chewing or other mechanical effects. This odor is strongly associated with the volatile sulfur compounds that can be used for the characterization of garlic. In this study, different varieties of garlic were examined for their volatile sulfur compound concentration, which may be used for purposes of quality control as well as for authentication and classification of garlic varieties. 2- or 3-vinyl-4H-1, 2- or 3-dithiin, allicin, allyl mercaptan, allyl methyl disulfide, allyl methyl sulfide, allyl methyl tetrasulfide, allyl methyl thiosulfide, allyl methyl trisulfide, diallyl disulfide, diallyl sulfide, diallyl tetrasulfide, diallyl trisulfide, dimethyl …
Genetic Diversity Of Pinto And Fresh Bean (Phaseolus Vulgaris L.) Germplasm Collected From Erzincan Province Of Turkey By Inter-Primer Binding Site (Ipbs) Retrotransposon Markers, Hali̇l İbrahi̇m Öztürk, Ati̇lla Dursun, Arash Hosseinpour, Kami̇l Hali̇loğlu
Genetic Diversity Of Pinto And Fresh Bean (Phaseolus Vulgaris L.) Germplasm Collected From Erzincan Province Of Turkey By Inter-Primer Binding Site (Ipbs) Retrotransposon Markers, Hali̇l İbrahi̇m Öztürk, Ati̇lla Dursun, Arash Hosseinpour, Kami̇l Hali̇loğlu
Turkish Journal of Agriculture and Forestry
In this study, genetic diversity among 71 bean genotypes (41 pinto beans and 30 fresh bean genotypes) and 4 commercial cultivars (Aleyna, Gina, Perolar, and Serra) commonly grown at Erzincan province in Turkey were investigated. The iPBS (inter-primer binding site) markers were used to investigate the genetic diversity of the genotypes. Polymorphism ratio was identified as 100% in all primers. Twenty-seven primers were studied and number of alleles in primers varied between 13?69 (with an average value of 37.14). According to cluster analysis based on iPBS data, genotypes were divided into 2 groups. Polymorphic information content (PIC) values varied between …
Structural And Ecological Characteristics Of Mixed Broadleaved Old-Growth Forest (Biogradska Gora - Montenegro), Milic Curovic, Velibor Spalevic, Paul Sestras, Renzo Motta, Catalina Dan, Matteo Garbarino, Alessandro Vitali, Carlo Urbinati
Structural And Ecological Characteristics Of Mixed Broadleaved Old-Growth Forest (Biogradska Gora - Montenegro), Milic Curovic, Velibor Spalevic, Paul Sestras, Renzo Motta, Catalina Dan, Matteo Garbarino, Alessandro Vitali, Carlo Urbinati
Turkish Journal of Agriculture and Forestry
Biogradska Gora National Park in Montenegro is part of the Dinaric Mountains mixed forest, which belongs to the montane region of the Dinaric Alps. This paper presents some of the main structural and ecological characteristics of the mixed broadleaved old-growth forest with beech [Fagus moesiaca (Domin, Maly) Czecz.], sycamore maple (Acer pseudoplatanus L.) and European ash (Fraxinus excelsior L.) from the preserve area of the Biogradska Gora. These forest ecosystems are characterized by the high species richness and potential productivity. In the study area, 58 vascular plant species were recorded in 4 sample plots of 0.25 ha each. The average …
Fabrication And Biocompatibility Assessment Of Polypyrrole/Cobalt(Ii) Metal-Organic Frameworks Nanocomposite, Mehrnaz Mehrabani, Zeinab Ansari Asl, Farzaneh Rostamzadeh, Saeideh Jafarinejad Farsangi, Mahnaz Sadat Hashemi, Mozhgan Sheikholeslami, Zeinab Neisi
Fabrication And Biocompatibility Assessment Of Polypyrrole/Cobalt(Ii) Metal-Organic Frameworks Nanocomposite, Mehrnaz Mehrabani, Zeinab Ansari Asl, Farzaneh Rostamzadeh, Saeideh Jafarinejad Farsangi, Mahnaz Sadat Hashemi, Mozhgan Sheikholeslami, Zeinab Neisi
Turkish Journal of Chemistry
Nowadays, metal-organic frameworks (MOFs) have emerged as promising tools for different biological applications and therefore, efforts are ongoing to develop more biocompatible MOFs-based nanocomposites. We aimed to fabricate some new conductive nanocomposites of polypyrrole and cobalt-MOF with different weight percentages (PPy/x%Co-MOF)usingthesolutionmixingmethodandcharacterizethemthroughFT-IR(Fourier-transforminfrared), PXRD (powder X-ray diffraction), SEM (scanning electron microscope), and TEM (transmission electron microscope) techniques. The biocompatibility of nanocomposites was assessed by haemolytic, cytotoxic, and quantitative reverse transcription PCR (qRT-PCR) assays. FT-IR and PXRD results revealed that nanocomposites consisted of pure MOFs and PPy. Moreover, SEM results indicated their spherical morphology along with an average diameter of 190 nm. (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium …
Hosphorus-Nitrogen Compounds (Part 51): The Relationship Between Spectroscopic And Crystallographic Data Of Mono- And Di-Spirocyclophosphazene Derivatives With 4-Fluoro/Nitrophenylmethyl Pendant Arm/Arms, Aytuğ Okumuş, Gamze Elmas, Nuran Asmafi̇li̇z, Selen Bi̇lge Koçak, Zeynel Kiliç
Hosphorus-Nitrogen Compounds (Part 51): The Relationship Between Spectroscopic And Crystallographic Data Of Mono- And Di-Spirocyclophosphazene Derivatives With 4-Fluoro/Nitrophenylmethyl Pendant Arm/Arms, Aytuğ Okumuş, Gamze Elmas, Nuran Asmafi̇li̇z, Selen Bi̇lge Koçak, Zeynel Kiliç
Turkish Journal of Chemistry
A great wealth of structural information about phosphazenes can be gleaned from the combined spectroscopic and crystallographic data. When data from $^{31}$P NMR spectroscopy and X-ray crystallography are put together like pieces in a puzzle, a number of correlations can be obtained for phosphazene derivatives. A systematic study concerning the correlations among the structural parameters (e.g., $^{31}$P NMR data, endocyclic/exocyclic NPN bond angles and bond lengths) revealed some characteristics of mono- and di-spirocyclophosphazene derivatives bearing~4-fluoro/nitrophenylmethyl pendant arm/arms. These correlations include the relationship between the $\delta $P$_{spiro}$ shifts, the values of electron density transfer parameters $\Delta $(P--N), and the endocyclic and …
Synthesis, Characterization And Crystal Structures Of Platinum(Ii) Saccharinate Complexes With 1,5-Cyclooctadiene, Ceyda İçsel
Synthesis, Characterization And Crystal Structures Of Platinum(Ii) Saccharinate Complexes With 1,5-Cyclooctadiene, Ceyda İçsel
Turkish Journal of Chemistry
Two new platinum(II) complexes, namely [PtCl(sac)(COD)] (1) and [Pt(sac)$_{2}$(COD)] (2) (sac $=$ saccharinate and COD $=$ 1,5-cyclooctadiene), were synthesized and characterized by elemental analysis, IR, NMR, ESI-MS spectroscopic and thermal analysis (TG/DTA) methods. The platinum(II) complexes were prepared from the reaction of [PtCl$_{2}$(COD)] with Na(sac) • 2H$_{2}$O. The addition of the sac ligand resulted in the replacement of 1 and 2 chlorido ligands in [PtCl$_{2}$(COD)] to yield 1 and 2, respectively. The structures of the complexes were determined by single crystal X-ray diffraction and showed a distorted square planar coordination geometry around platinum(II). COD acted as a $\pi $-donor ligand, …
Characterization And Kinetics Analysis Of The Thermal Decomposition Of The Humic Substance From Hazelnut Husk, Fatma Kara, Duygu Adigüzel, Ufuk Atmaca, Murat Çeli̇k, Jale Nakti̇yok
Characterization And Kinetics Analysis Of The Thermal Decomposition Of The Humic Substance From Hazelnut Husk, Fatma Kara, Duygu Adigüzel, Ufuk Atmaca, Murat Çeli̇k, Jale Nakti̇yok
Turkish Journal of Chemistry
A humic substance was obtained from hazelnut husk using an alkali extraction. The chemical and morphological structure of the humic matter was characterized via elemental analysis, Fourier transform infrared spectrometry (FTIR), nuclear magnetic resonance, Brunauer-Emmet-Teller (BET) analysis, scanning electron microscopy (SEM), and thermogravimetric-FTIR (TG-FTIR). In addition, thermal analysis measurements TG analysis-differential thermogravimetry/differential scanning calorimetry (TGA-DTG/ DSC) were performed under dynamic air conditions to better determine the origin, physical and chemical structure, and decomposition process of the humic matter. The Kissinger-Akahira-Sunose (KAS) and Flynn-Wall-Ozawa (FWO) methods were used to calculate the kinetic parameters of the high-temperature decomposition process. It was observed …
Effect Of Ph On Lipid Oxidation Of Red Onion Skin Extracts Treated With Washed Tilapia (Oreochromis Niloticus) Muscle Model Systems, Senem Güner, Yavuz Yağiz, Zeynal Topalcengi̇z, Hordur G. Kristinsson, George Baker, Paul Sarnoski, Bruce A. Welt, Amarat Simonne, Maurice M. Marshall
Effect Of Ph On Lipid Oxidation Of Red Onion Skin Extracts Treated With Washed Tilapia (Oreochromis Niloticus) Muscle Model Systems, Senem Güner, Yavuz Yağiz, Zeynal Topalcengi̇z, Hordur G. Kristinsson, George Baker, Paul Sarnoski, Bruce A. Welt, Amarat Simonne, Maurice M. Marshall
Turkish Journal of Chemistry
The aim of the study was to investigate the effect of pH on the lipid oxidation of red onion skin extracts (ROSEs) treated with washed tilapia muscle model systems (WTMS). Minced and buffered washed samples were prepared at pH 6.3 and 6.8. The WTMS were treated with2 different concentrations of red onion skin prior to storage for 5 days. Lipid oxidation was investigated via peroxide values (PVs), thiobarbituric acid reactive substances (TBARS), and the formation of volatile compounds. Fatty acid profiles of the samples were also identified. The ROSEs were able to significantly suppress the PV (~71%) and TBARS (~42%) …
Synthesis And Electrochemical Properties Of Copper(Ii), Manganese(Iii) Phthalocyanines Bearing Chalcone Groups At Peripheral Or Nonperipheral Positions, Hüseyi̇n Baş, Nuran Kahri̇man, Zekeri̇ya Biyiklioğlu
Synthesis And Electrochemical Properties Of Copper(Ii), Manganese(Iii) Phthalocyanines Bearing Chalcone Groups At Peripheral Or Nonperipheral Positions, Hüseyi̇n Baş, Nuran Kahri̇man, Zekeri̇ya Biyiklioğlu
Turkish Journal of Chemistry
In this study, new chalcone compound 1, new phthalonitrile derivatives 2 and 3, new copper(II), manganese(III) phthalocyanines bearing chalcone groups at peripheral or nonperipheral positions were synthesized. Electrochemistry of tetra-(4- {(2E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoyl}phenoxy) substituted Co(II)Pc and Mn(III)Pcs were studied with cyclic voltammetry (CV) to determine the redox properties of the phthalocyanines. According to the results, while the CuPcs 2a and 3a showed two Pc based reduction reactions and one Pc based oxidation reaction, MnPcs 2b and 3b gave two metal-based reduction reactions. All the redox processes are shifted toward positive potentials as a result of the increased electron-withdrawing ability of the trifluoromethyl …
Mitochondrial Genome Sequencing And Phylogenetic Analysis Of Cynodon Dactylon × Cynodon Transvaalensis, Shilian Huang, Yancai Shi, Miao Chen
Mitochondrial Genome Sequencing And Phylogenetic Analysis Of Cynodon Dactylon × Cynodon Transvaalensis, Shilian Huang, Yancai Shi, Miao Chen
Turkish Journal of Botany
Cynodon dactylon × Cynodon transvaalensis is one of the most important turfgrasses. Sequencing the C. dactylon × C. transvaalensis mitochondrial genome can help us learn more about its genomic composition and allow further study of the population genetics, taxonomy, and evolutionary biology of Poaceae plants and other related species. Here the C. dactylon × C. transvaalensis mitochondrial genome was sequenced using Illumina HiSeq combined with PacBio sequencing technology, and the map of the mitochondrial genome was constructed after de novo assembly and annotation. The C. dactylon × C. transvaalensis mitochondrial genome has 366,612 bp and contains 53 genes, including 31 …
Genetic Diversity Of The Critically Endangered Ferula Sinkiangensis K.M.Shen (Apiaceae) And The Implications For Conservation, Wenjun Li, Zhihao Su, Lei Yang, Qiumei Cao, Ying Feng
Genetic Diversity Of The Critically Endangered Ferula Sinkiangensis K.M.Shen (Apiaceae) And The Implications For Conservation, Wenjun Li, Zhihao Su, Lei Yang, Qiumei Cao, Ying Feng
Turkish Journal of Botany
Research on the genetic diversity and structures of endangered plant species with small population sizes is a prerequisite for developing reasonable conservation strategies. Ferula sinkiangensis K.M.Shen is a critically endangered herbaceous perennial and monocarpic medical plant growing in semiarid steppe ecosystems with a small population size within the Yili Valley in Xinjiang, China. Unfortunately, the lack of genetic information has limited our ability to initiate effective conservation strategies for the species. In this study, 14 polymorphic microsatellite primers of F. sinkiangensis were developed and characterized using Illumina HiSeq paired-end reads from genomic DNA. Primers were used to assess the genetic …
Termitomyces Sheikhupurensis Sp. Nov. (Lyophyllaceae, Agaricales) From Pakistan, Evidence From Morphology And Dna Sequences Data, Aiman Izhar, Abdul Nasir Khalid, Hira Bashir
Termitomyces Sheikhupurensis Sp. Nov. (Lyophyllaceae, Agaricales) From Pakistan, Evidence From Morphology And Dna Sequences Data, Aiman Izhar, Abdul Nasir Khalid, Hira Bashir
Turkish Journal of Botany
A new symbiotic species from genus Termitomyces, is proposed here supported by morphological features and molecular evidence. The species is characterized by an annual growth, pileus with velar remnants, ruptured margins, pubescent stipe with short pseudorhiza, basidia varying in wall thickness, polymorphic cheilo- and pleurocystidia as well as two types of pileipellis hyphae. Sequences of nr ITS and LSU regions of newly reported species nested as a separate taxon in both phylogenetic analyses of current study.
Phylogenetic And Biogeographical History Confirm The Anatolian Origin Of Bornmuellera (Brassicaceae) And Clade Divergence Between Anatolia And The Balkans In The Plio-Pleistocene Transition, Bariş Özüdoğru, Klaus Mummenhoff
Phylogenetic And Biogeographical History Confirm The Anatolian Origin Of Bornmuellera (Brassicaceae) And Clade Divergence Between Anatolia And The Balkans In The Plio-Pleistocene Transition, Bariş Özüdoğru, Klaus Mummenhoff
Turkish Journal of Botany
Understanding disjunct distribution patterns in the Balkan Peninsula and Anatolia is important in order to reconstruct robust biogeographical hypotheses. This is instrumental in understanding the recolonization patterns of Europe during the Quaternary glaciation/interglaciation periods and the potential role of Anatolia as a refugium. Unfortunately, only a few studies have been conducted to uncover such processes. Here, we used all eight species of the genus Bornmuellera (Brassicaceae) with a scattered distribution in the Balkans and Anatolia to reconstruct its biogeographic history. We applied nuclear internal transcribed spacer (ITS) and plastid trnL-F regions and showed that 1) Bornmuellera is monophyletic and, 2) …
Evaluation Of Recombinant Human Vascular Endothelial Growth Factor Vegf121-Loaded Poly-L-Lactide Microparticles As A Controlled Release Delivery System, Sunil Abraham, Srinivasa Prasad Rangaswamy, Amutha Chinnaiah
Evaluation Of Recombinant Human Vascular Endothelial Growth Factor Vegf121-Loaded Poly-L-Lactide Microparticles As A Controlled Release Delivery System, Sunil Abraham, Srinivasa Prasad Rangaswamy, Amutha Chinnaiah
Turkish Journal of Biology
Vascular endothelial growth factor A (VEGF-A) is an important growth factor that plays a major role in angiogenesis. With different isoforms distributed in various tissues, the shortest isoform of VEGF-A is VEGF121, one of the physiologically functional variants next to VEGF165. It is well known that VEGF has a shorter half-life, and the stability of the protein must be considered in therapeutic aspects. Poly-l-lactide (PLA) microparticles can release the encapsulated protein in a sustained release mode. In this study, the VEGF121 gene was cloned and expressed in a prokaryotic expression system (Escherichia coli). The recombinant VEGF121 was encapsulated with PLA …
Oncogenic And Tumor Suppressor Function Of Meis And Associated Factors, Bi̇rkan Gi̇rgi̇n, Medi̇ne Karadağ Alpaslan, Fati̇h Kocabaş
Oncogenic And Tumor Suppressor Function Of Meis And Associated Factors, Bi̇rkan Gi̇rgi̇n, Medi̇ne Karadağ Alpaslan, Fati̇h Kocabaş
Turkish Journal of Biology
MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated in various cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in …
Signature Changes In The Expressions Of Protein-Coding Genes, Lncrnas, And Repeat Elements In Early And Late Cellular Senescence, Gökhan Karakülah, Ci̇hangi̇r Yandim
Signature Changes In The Expressions Of Protein-Coding Genes, Lncrnas, And Repeat Elements In Early And Late Cellular Senescence, Gökhan Karakülah, Ci̇hangi̇r Yandim
Turkish Journal of Biology
Replicative cellular senescence is the main cause of aging. It is important to note that early senescence is linked to tissue regeneration, whereas late senescence is known to trigger a chronically inflammatory phenotype. Despite the presence of various genome-wide studies, there is a lack of information on distinguishing early and late senescent phenotypes at the transcriptome level. Particularly, the changes in the noncoding RNA portion of the aging cell have not been fully elucidated. By utilising RNA sequencing data of fibroblasts, hereby, we are not only reporting changes in gene expression profiles and relevant biological processes in the early and …
Ptdins(4,5)P2 And Ptdins(3,4,5)P3 Dynamics During Focal Adhesions Assembly And Disassembly In A Cancer Cell Line, Dhurgham Alfahad, Salem Alharethi, Bandar Alharbi, Khatab Mawlood, Philip Dash
Ptdins(4,5)P2 And Ptdins(3,4,5)P3 Dynamics During Focal Adhesions Assembly And Disassembly In A Cancer Cell Line, Dhurgham Alfahad, Salem Alharethi, Bandar Alharbi, Khatab Mawlood, Philip Dash
Turkish Journal of Biology
Focal adhesions (FAs) are large assemblies of proteins that mediate intracellular signals between the cytoskeleton and the extracellular matrix (ECM). The turnover of FA proteins plays a critical regulatory role in cancer cell migration. Plasma membrane lipids locally generated or broken down by different inositide kinases and phosphatase enzymes to activate and recruit proteins to specific regions in the plasma membrane. Presently, little attention has been given to the use of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) fluorescent biosensors in order to determine the spatiotemporal organisation of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 within and around or during assembly and disassembly of …
Sex Effect On The Correlation Of Immunoglobulin G Glycosylation With Rheumatoid Arthritis Disease Activity, Altan Ercan
Sex Effect On The Correlation Of Immunoglobulin G Glycosylation With Rheumatoid Arthritis Disease Activity, Altan Ercan
Turkish Journal of Biology
Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects females more than males with a presence of autoantibodies. Immunoglobulin G (IgG) produced by adaptive arm has 2 functional domains, Fc and Fab. The Fc domain binds Fc gamma receptors and C1q proteins of the innate arm. Therefore, the IgG Fc domain serves as a bridge between the innate and adaptive arms and is regulated by an evolutionarily conserved N-glycosylation with variable structures. These glycans are classified as agalactosylated G0, monogalactosylated G1, and digalactosylated G2, which are further modified by core-fucosylation (F) and bisecting N-acetylglucosamine (B) moieties such as G0F …
The Methanolic Extract Of Garcinia Atroviridis (Mega) Reduces Body Weight And Food Intake, And Improves Lipid Profiles By Altering The Lipid Metabolism: A Rat Model, Wai Feng Lim, Suriati Mohd Nasir, Lay Kek Teh, Richard Johari James, Mohd Hafidz Mohd Izhar, Mohd Zaki Salleh
The Methanolic Extract Of Garcinia Atroviridis (Mega) Reduces Body Weight And Food Intake, And Improves Lipid Profiles By Altering The Lipid Metabolism: A Rat Model, Wai Feng Lim, Suriati Mohd Nasir, Lay Kek Teh, Richard Johari James, Mohd Hafidz Mohd Izhar, Mohd Zaki Salleh
Turkish Journal of Biology
Garcinia species are widely used for their slimming effects via increased fat burning and suppression of satiety. However, scientific evidence for the biological effects of Garcinia atroviridis (GA) is lacking. We investigated the phytochemical composition, safety profiles, and antioxidant and antiobesity effects of methanolic extracts of Garcinia atroviridis (MeGa) in obese female rats. Repeated dose toxicity studies were conducted according to the OECD guidelines. Upon sacrifice, haematological, biochemical, lipid profile, and serum-based metabolomics analyses were performed to evaluate metabolic expression changes and their related pathways. MeGa contains several phytochemical groups and GA fruit acids. MeGa was found to be nontoxic …
Expression Of Soluble, Active, Fluorescently Tagged Hephaestin In Cos And Cho Cell Lines, Eli̇f Si̇bel Aslan, Kenneth N. White, Basharut A. Syed, Kaila S. Srai, Robert W. Evans
Expression Of Soluble, Active, Fluorescently Tagged Hephaestin In Cos And Cho Cell Lines, Eli̇f Si̇bel Aslan, Kenneth N. White, Basharut A. Syed, Kaila S. Srai, Robert W. Evans
Turkish Journal of Biology
Hephaestin (Hp) is a trans-membrane protein, which plays a critical role in intestinal iron absorption. Hp was originally identified as the gene responsible for the phenotype of sex-linked anaemia in the sla mouse. The mutation in the sla protein causes accumulation of dietary iron in duodenal cells, causing severe microcytic hypochromic anaemia. Although mucosal uptake of dietary iron is normal, export from the duodenum is inhibited. Hp is homologous to ceruloplasmin (Cp), a member of the family of multi copper ferroxidases (MCFs) and possesses ferroxidase activity that facilitates iron release from the duodenum and load onto the serum iron transport …
Genome-Wide Identification Of Chiari Malformation Type I Associated Candidate Genes And Chromosomal Variations, Ti̇muçi̇n Avşar, Şeyma Çaliş, Baran Yilmaz, Gülden Demi̇rci̇ Otluoğlu, Can Holyavki̇n, Türker Kiliç
Genome-Wide Identification Of Chiari Malformation Type I Associated Candidate Genes And Chromosomal Variations, Ti̇muçi̇n Avşar, Şeyma Çaliş, Baran Yilmaz, Gülden Demi̇rci̇ Otluoğlu, Can Holyavki̇n, Türker Kiliç
Turkish Journal of Biology
Chiari malformation type I (CMI) is a brain malformation that is characterized by herniation of the cerebellum into the spinal canal. Chiari malformation type I is highly heterogeneous; therefore, an accurate explanation of the pathogenesis of the disease is often not possible. Although some studies showed the role of genetics in CMI, the involvement of genetic variations in CMI pathogenesis has not been thoroughly elucidated. Therefore, in the current study we aim to reveal CMI-associated genomic variations in familial cases. Four CMI patients and 7 unaffected healthy members of two distinct families were analyzed. A microarray analysis of the affected …
Applying Stable Isotopes Of Carbon (Δ$^{13}$C) And Nitrogen (Δ$^{15}$N) To Examine The Role Ofpikeperch (Sander Lucioperca Linnaeus, 1758) In Structuring The Food Web Oflake Eğirdir (Central Anatolia), Turkey, Meral Apaydin Yağci, Şenol Akin, Ahmet Alp, Abdulkadi̇r Yağci, Mehmet Cesur, Rahmi̇ Uysal, Fuat Bi̇lgi̇n, Vedat Yegen
Applying Stable Isotopes Of Carbon (Δ$^{13}$C) And Nitrogen (Δ$^{15}$N) To Examine The Role Ofpikeperch (Sander Lucioperca Linnaeus, 1758) In Structuring The Food Web Oflake Eğirdir (Central Anatolia), Turkey, Meral Apaydin Yağci, Şenol Akin, Ahmet Alp, Abdulkadi̇r Yağci, Mehmet Cesur, Rahmi̇ Uysal, Fuat Bi̇lgi̇n, Vedat Yegen
Turkish Journal of Zoology
The aim of this study was to examine the role of pikeperch (Sander lucioperca L., 1758) in structuring the seasonal food web of Lake Eğirdir using carbon (δ$^{13}$C) and nitrogen (δ$^{15}$N) stable isotopes. The samples for stable isotopes were collected during the spring and autumn seasons. Sander lucioperca, as expected, was determined as a top predator with a substantially higher trophic position during both seasons (3.96, spring, δ$^{15}$N (mean ± SE = 13.09 ± 0.17) and δ$^{13}$C (mean ± SE = -17.23 ± 0.19) (4.10, autumn, δ$^{15}$N (mean ± SE = 14.14 ± 0.19) and δ$^{13}$C (mean ± SE = …
Insecticidal Effect Of Diatomaceous Earth And Dolomite Powder Against Corn Weevilsitophilus Zeamais Motschulsky, 1855 (Coleoptera: Curculionidae), Alyssa Cristina Oliveira Freitas, Adriana Aparecida Sinopólis Gigliolli, Ronaldo Roberto Tait Caleffe Caleffe, Helio Conte
Insecticidal Effect Of Diatomaceous Earth And Dolomite Powder Against Corn Weevilsitophilus Zeamais Motschulsky, 1855 (Coleoptera: Curculionidae), Alyssa Cristina Oliveira Freitas, Adriana Aparecida Sinopólis Gigliolli, Ronaldo Roberto Tait Caleffe Caleffe, Helio Conte
Turkish Journal of Zoology
Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae) which develops inside the grain, is an aggressive pest of stored grains. Here, we evaluated the efficiency of diatomaceous earth (DE), Diatomita CI/325 CX, and dolomite (DOL), Dolomita Dr. Kanyo, against S. zeamais reared on corn under laboratory conditions and observed external alterations on treated insects using scanning electron microscopy (SEM). Insects treated with both DE and DOL were impregnated with particles on the body surface, and they showed 100% mortality after 10 days of exposure. Damages caused by inert dusts may have contributed to dehydration and desiccation, consequently, leading insects to death. Thus, …