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The Effect Of Putrescine On Dna Methylation On Cabbage Plant Under Salt Stress Conditions, Emi̇ne Orhan, Furkan Uzundumlu, Esma Yi̇ği̇der, Murat Aydin
The Effect Of Putrescine On Dna Methylation On Cabbage Plant Under Salt Stress Conditions, Emi̇ne Orhan, Furkan Uzundumlu, Esma Yi̇ği̇der, Murat Aydin
Turkish Journal of Agriculture and Forestry
Although studies on tolerance to abiotic stress conditions in cabbage species and varieties have been carried out, these studies have generally been conducted in field and greenhouse pot experiments. In such studies, morphological measurements and evaluations have been made. However, there are deficiencies in physiological and molecular detection studies. Therefore, this study focused on detecting any DNA methylation change in the genome of cabbage seedlings when NaCl (salt stress) in combination with putrescine (Put) was applied. Different concentrations of NaCl and Put were applied to white head cabbage (Brassica oleraceae L. cv Yalova-F1). Germination rate, root length, shoot length, seedling …
Screening Of Factors Affecting Somatic Callusing And Embryo Induction In Allium Cepa L.Through Plackett?Burman Methodology, Kourosh Keighobadi, Maryam Golabadi, Mahdi Khozaei, Abdol Majid Rezai
Screening Of Factors Affecting Somatic Callusing And Embryo Induction In Allium Cepa L.Through Plackett?Burman Methodology, Kourosh Keighobadi, Maryam Golabadi, Mahdi Khozaei, Abdol Majid Rezai
Turkish Journal of Agriculture and Forestry
Induction of embryonic callus through available asexual explant culture is applied in the protection and maintenance of cytoplasmic-male sterility and in the maintenance of other lines of onion (Allium cepa L.). Usage of the Plackett?Burman (PB) experimental design has been suggested as a screening method for many variables that influence the desired induction. In order to overcome limitations of standard experimental designs and prioritization of media culture components, a systematic investigation was carried out using the PB design. In this investigation, the effects of different factors such as 2,4-D, putrescine, carbohydrate sources (maltose, sorbitol, and sucrose), silver nitrate, glutamine, and …
Identification Of Genetic Diversity Among Mutant Lemon And Mandarin Varieties Usingdifferent Molecular Markers, Görkem Sülü, Yildiz Kaçar, İlknur Polat, Aytül Ki̇tapci, Ertuğrul Turgutoğlu, Özhan Şi̇mşek, Gül Satar
Identification Of Genetic Diversity Among Mutant Lemon And Mandarin Varieties Usingdifferent Molecular Markers, Görkem Sülü, Yildiz Kaçar, İlknur Polat, Aytül Ki̇tapci, Ertuğrul Turgutoğlu, Özhan Şi̇mşek, Gül Satar
Turkish Journal of Agriculture and Forestry
Mandarin (Citrus reticulate Blanco) and lemon (C.limon L.) are among the most cultivated Citrus species in the world. Among different approaches, gamma radiation is widely used to induce mutations in citrus breeding studies. Gamma radiation causes DNA damage, randomly inducing several mutations in the genome. Molecular techniquesarewidely used to detect such induced mutations and genetic diversity in plants.In this study, simple sequence repeats (SSR), inter-simple sequence repeat (ISSR) and single-strand conformation polymorphism (SSCP) markers were used to detectthe induced mutations andgenetic diversityin someirradiated mandarin and lemon genotypes in comparison with standard citrus varieties. The irradiated genotypes used in this study …
Dna Fingerprinting And Genetic Diversity Analysis Of World Quinoa Germplasm Usingipbs-Retrotransposon Marker System, Muzaffer Barut, Muhammad Azhar Nadeem, Tolga Karaköy, Faheem Shahzad Baloch
Dna Fingerprinting And Genetic Diversity Analysis Of World Quinoa Germplasm Usingipbs-Retrotransposon Marker System, Muzaffer Barut, Muhammad Azhar Nadeem, Tolga Karaköy, Faheem Shahzad Baloch
Turkish Journal of Agriculture and Forestry
Quinoa is an important staple food crop for millions of impoverished rural inhabitants of the Andean region. Quinoa is considered a good source of protein,vitamins, minerals, and antioxidants. This study aimed to investigate the genetic diversity and population structure of world quinoa germplasm originating from 8 countries through the iPBS-retrotransposon marker system. Molecular characterization was performed using the 11 most polymorphic primers. A total of 235 bands were recorded, of which 66.8% were polymorphic. Mean polymorphism information content (PIC) was 0.410. Various diversity indices including mean effective number of alleles (1.269), mean Shannon's information index (0.160) and gene diversity (0.247) …
Dihydroquercetin Increases The Adaptive Potential Of Wild Soybean Against Copper Sulfateand Cadmium Sulfate Toxicity, Darya Konstantinovna Chernyshuk, Lubov Yegorovna Ivachenko, Hülya Doğan, Ghulam Raza, Muhammad Amjad Ali, Kirill Sergeyevich Golokhvast, Muhammad Amjad Nawaz
Dihydroquercetin Increases The Adaptive Potential Of Wild Soybean Against Copper Sulfateand Cadmium Sulfate Toxicity, Darya Konstantinovna Chernyshuk, Lubov Yegorovna Ivachenko, Hülya Doğan, Ghulam Raza, Muhammad Amjad Ali, Kirill Sergeyevich Golokhvast, Muhammad Amjad Nawaz
Turkish Journal of Agriculture and Forestry
In this study, the mechanism of the biochemical adaptation of wild soybean to the experimentally modeled effects of cadmium sulfate and copper sulfate in approximately double permissible concentration was investigated. The extracted concentrations of cadmium and copper in the experimental soil were determined by inversion voltammetry - 1.46 and 48.25 mg/kg, respectively. Growing soybeans in soil with the addition of copper and cadmium sulfates led to an increase in the concentration of malonic dialdehyde in soybean seeds relative to control by 62% and 38%, respectively, which confirmed the strengthening of oxidative processes. There was also an increase in the specific …
Changes In The Biochemical Compounds Of Vaccinium Myrtillus, Vaccinium Vitis-Idaea, And Forest Litter Collected From Various Forest Types, Vilma Kaskoniene, Kristina Bimbiraite-Surviliene, Paulius Kaskonas, Nicola Tiso, Laima Cesoniene, Remigijus Daubaras, Audrius Sigitas Maruska
Changes In The Biochemical Compounds Of Vaccinium Myrtillus, Vaccinium Vitis-Idaea, And Forest Litter Collected From Various Forest Types, Vilma Kaskoniene, Kristina Bimbiraite-Surviliene, Paulius Kaskonas, Nicola Tiso, Laima Cesoniene, Remigijus Daubaras, Audrius Sigitas Maruska
Turkish Journal of Agriculture and Forestry
The aim of this study was to evaluate the impact of forest clear-cutting on the phenolic compounds and antiradical activity of Vaccinium myrtillus, Vaccinium vitis-idaea, and forest litter collected during the vegetation stages in 2 forests types (Pinetum vacciniosum and Pinetum vaccinio-myrtillosum). The Folin-Ciocalteu method, aluminum trichloride colorimetric assay, and 2,2-diphenyl-1- picrylhydrazyl (DPPH) test were applied to perform the total phenolic content (TPC), total flavonoid content (TFC), and antiradical activity analyses of the extracts of the underground and aboveground parts of the plants and forest litter. The TPC content varied from 35.87 to 229.76 mg/g (expressed as rutin equivalents) and …
Efficient Protoplast Isolation From Ovule-Derived Embryogenic Callus In Citrus Volkameriana, Berken Çi̇men
Efficient Protoplast Isolation From Ovule-Derived Embryogenic Callus In Citrus Volkameriana, Berken Çi̇men
Turkish Journal of Agriculture and Forestry
The present study reports on the isolation of viable protoplast from ovule-derived embryogenic calli of Volkameriana (Citrus volkameriana L.), which is a rootstock in high demand for lemon production.Ovules of C. Volkameriana isolated at 3 different immature fruit stages, comprising4, 8, and 12 weeks after anthesis (WAA), were cultured on5 different media in order to produce embryogenic callus lines as a source material for protoplast isolation. EME medium (MT basal medium + 0.5 gL-1 malt extract), with the addition of phytohormones [kinetin (KIN), 2,4-dichlorophenoxyacetic acid (2,4-D) and 6-benzylaminopurine (BAP)] at different concentrations, were tested for callogenesis. According to 2-way ANOVA, …
Molecular Cytogenetic Characterization Of Common Bean (Phaseolus Vulgaris L.) Accessions, Gülsemi̇n Savaş Tuna, Gülru Yücel, Tansel Kaygisiz Aşçioğul, Duygu Ateş, Dursun Eşi̇yok, Muhammed Bahatti̇n Tanyolaç, Meti̇n Tuna
Molecular Cytogenetic Characterization Of Common Bean (Phaseolus Vulgaris L.) Accessions, Gülsemi̇n Savaş Tuna, Gülru Yücel, Tansel Kaygisiz Aşçioğul, Duygu Ateş, Dursun Eşi̇yok, Muhammed Bahatti̇n Tanyolaç, Meti̇n Tuna
Turkish Journal of Agriculture and Forestry
With an annual global production of approximately 25 million tons, the common bean (Phaseolus vulgaris L), a member of the genus Phaseolus, is one of the major protein sources used as food for humans. In this study, it was aimed to investigate the genome size of the common bean genetic resource collection (154 common bean accessions) in Turkey by flow cytometry (FCM) and determine whether geographical variables affected the genome size. In addition, the number and distribution of 5S and 45S ribosomal DNA loci were designated by performing a fluorescence in situ hybridization (FISH) analysis in some of the accessions. …
Determination Of The Chemical Composition Of Seeds, Peels, And Seedcakes From Two Genotypes Of Cape Gooseberry (Physalis Peruviana L.), Venelina Popova, Zhana Petkova, Tanya Ivanova, Magdalena Stoyanova, Nikolay Panayotov, Nadezhda Mazova, Albena Stoyanova
Determination Of The Chemical Composition Of Seeds, Peels, And Seedcakes From Two Genotypes Of Cape Gooseberry (Physalis Peruviana L.), Venelina Popova, Zhana Petkova, Tanya Ivanova, Magdalena Stoyanova, Nikolay Panayotov, Nadezhda Mazova, Albena Stoyanova
Turkish Journal of Agriculture and Forestry
Physalis peruviana L. fruit (Cape gooseberry, CG) is a rich source of phytonutrients, including vitamins, minerals, polyphenols, polyunsaturated fatty acids (FAs), phytosterols, dietetic fibers, and others. The popularity and production areas of CG have been expanding worldwide, thus producing fruit with origin-substantiated differences in their nutrient composition.This study was based on the comparative assessment of 2 genotypes of CG produced in Bulgaria (CG-P and CG-F), through analysis of the lipid fraction of different fruit elements (seeds, peels), and further examination of the extracted seedcakes. The CG seeds reasonably yielded more oil (17.0%-22.2%) than the isolated peels (2.8%-2.9%). The main FAs …
Seed Fatty Acid Compositions And Chemotaxonomy Of Wild Crambe (Brassicaceae) Taxa In Turkey, İlhan Subaşi
Seed Fatty Acid Compositions And Chemotaxonomy Of Wild Crambe (Brassicaceae) Taxa In Turkey, İlhan Subaşi
Turkish Journal of Agriculture and Forestry
Wild Crambe species have greater potential than Crambe hispanica in industry, medicine, as a vegetable, etc. A total of 53 germplasm accessions, belonging to 7 taxa, were collected from the natural flora of Turkey. The accessions consisted of C. orientalis var. orientalis (18 accessions), C. orientalis var. dasycarpa (1 accession), C. orientalis var. sulphurea (2 accessions), C.tataria var. aspera (3 accessions), C. tataria var. tataria (26 accessions), C. grandiflora (1 accession), C. orientalis var. sulphurea, and C. maritima (2 accessions). In this study, the seed fatty acid compositions and oil contents were determined, and the data were used for taxonomic …
2-[(3-Aminoalkyl-(Alkaryl-,Aryl-))-1 H-1,2,4-Triazol-5-Yl]Anilines: Synthesis And Anticonvulsant Activity, Yulya Martynenko, Galina Berest, Nina Bukhtiayrova, Igor Belenichev, Oleksiy Voskoboinik, Sergiy Kovalenko
2-[(3-Aminoalkyl-(Alkaryl-,Aryl-))-1 H-1,2,4-Triazol-5-Yl]Anilines: Synthesis And Anticonvulsant Activity, Yulya Martynenko, Galina Berest, Nina Bukhtiayrova, Igor Belenichev, Oleksiy Voskoboinik, Sergiy Kovalenko
Turkish Journal of Chemistry
The presented work is devoted to the development of synthesis methods for novel 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1$H$-1,2,4-triazolo]anilines. Abovementioned compounds were obtained via hydrazinolysis (Ing-Manske procedure) and acid hydrolysis of corresponding $N$-acylated {([1,2,4]triazolo[1,5-$c$]quinazolin-2-yl)alkyl-(alkaryl-, aryl-)} amines. The regioselectivity of hydrazinolysis and hydrolysis were established. The features of spectral characteristics were studied and discussed. Characteristic patterns of protons signals splitting in $^{1}$H NMR of the synthesized compounds were established. The effect of the synthesized compounds on the pentylenetetrazol seizures was studied. It was found that according to some indicators, anticonvulsant activity of 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1$H$-1,2,4-triazolo]anilines superior or comparable with effect of the reference drug "Lamotrigine". It …
New Sandwich-Type Polymeric Potassium-Dicyanoargentate(I) Complex: Synthesis, Characterization And Enzymatic Activity, Nesri̇n Korkmaz
New Sandwich-Type Polymeric Potassium-Dicyanoargentate(I) Complex: Synthesis, Characterization And Enzymatic Activity, Nesri̇n Korkmaz
Turkish Journal of Chemistry
Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)-based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated. When the infrared (IR) spectrum of the complex is examined, the OH vibration peak resulting from H$_{2}$O molecules in the structure at 3948-3337 cm$^{-1}$ and at 2138 cm$^{-1}$, along with a CN peak coordinated …
Evolutionary Analyses Of Phylum Chaetognatha Based On Mitochondrial Cytochromeoxidase I Gene, Sam Peter, Manojkumar Bhaskaran Nair, Devika Pillai
Evolutionary Analyses Of Phylum Chaetognatha Based On Mitochondrial Cytochromeoxidase I Gene, Sam Peter, Manojkumar Bhaskaran Nair, Devika Pillai
Turkish Journal of Zoology
Chaetognaths (arrow worms) are an enigmatic group of transparent planktonic invertebrates and play an important role in the marine food web. Their morphological and developmental features have raised extensive debates since the discovery of the phylum in the 18th century. Uncertainty in the phylogenetic placement of certain chaetognath species still exists and is puzzling many scientists who have tried to clarify this task. Studies using a portion of both small subunit ribosomal ribonucleic acid (SSU rRNA) and large subunit ribosomal ribonucleic acid (LSU rRNA) genes when integrated with conventional taxonomy were contributed to resolve taxonomical issues in this group. Here …
The Occurrence Of Xanthochroism In The Thinlip Grey Mullet, Chelon Ramada(Teleostei: Mugilidae), From The Aegean Sea, Sencer Akalin, Zafer Tosunoğlu
The Occurrence Of Xanthochroism In The Thinlip Grey Mullet, Chelon Ramada(Teleostei: Mugilidae), From The Aegean Sea, Sencer Akalin, Zafer Tosunoğlu
Turkish Journal of Zoology
In this study, the first case of aberrant coloration, namely xanthochroism or xanthism, in the thinlip grey mullet, Chelon ramada (Teleostei: Mugilidae), was reported. The specimen was caught by a purse seiner in November 2019, in İzmir Bay, in the Aegean Sea, and was a female, with mature ovaries, which indicated that it had been in spawning migration or activity on the sampling date.
Blue Dye Degradation In An Aqueous Medium By A Combined Photocatalytic Andbacterial Biodegradation Process, Gabriela Perez Osorio, Flor Del Rocio Hernandez Gomez, Janette Arriola Morales, Maribel Castillo Morales, Jose Carlos Mendoza Hernandez
Blue Dye Degradation In An Aqueous Medium By A Combined Photocatalytic Andbacterial Biodegradation Process, Gabriela Perez Osorio, Flor Del Rocio Hernandez Gomez, Janette Arriola Morales, Maribel Castillo Morales, Jose Carlos Mendoza Hernandez
Turkish Journal of Chemistry
This paper aimed at implementing a treatment system for polluted water with textile dyes, starting with a photocatalytic decomposition process using sunlight as a source of energy and continuing with a bacterial biodegradation process, in order to reach degradation percentages higher than those obtained using only one of the processes mentioned above. When water treatment with the dye in the combined system was over, an acute ecotoxicity test was performed to make sure that toxic metabolites were not produced due to biodegradation. Solophenyl Blue azoic dye, and Erionyl Blue and Terasil Blue anthraquinone dye-colored solutions were treated with the Pd/Al$_{80}$ …
Selective Modifications At The Different Positions Of Cyclodextrins: A Review Of Strategies, Jia Yue Liu, Xiao Zhang, Bingren Tian
Selective Modifications At The Different Positions Of Cyclodextrins: A Review Of Strategies, Jia Yue Liu, Xiao Zhang, Bingren Tian
Turkish Journal of Chemistry
Cyclodextrins (CDs) are natural, nontoxic, and biodegradable macrocyclic oligosaccharides. As supramolecular hosts, CDs have numerous applications in many aspects. However, nonsubstituted CDs have the disadvantages of solubility, unspecific recognition sites, and weak interactions with guest molecules. Therefore, new CD-based derivatives are successfully designed, synthesized, and widely used in various fields. This contribution outlines the research progress in CD derivatives. In particular, this review emphasizes the synthesis and application of CDs modified through functionalization in definite positions, random substitution, and reconstruction of the skeleton. At the end of this review, a summary and future directions are presented.
Bioreduction: The Biological Activity, Characterization, And Synthesis Of Silver Nanoparticles, Nesri̇n Korkmaz
Bioreduction: The Biological Activity, Characterization, And Synthesis Of Silver Nanoparticles, Nesri̇n Korkmaz
Turkish Journal of Chemistry
Today, nanoparticles are effectively used in different areas. Initially, physical and chemical methods were used in the synthesis of nanoparticles. Biosynthesis (green synthesis) has emerged as an alternative to overcome the toxic effects of chemically synthesized nanoparticles. In this study, green synthesis of silver nanoparticles (AgNPs) with the leaf extract of Anthurium andraeanum was performed. UV-Vis spectrophotometry, scanning transmission electron microscopy, and XRD were applied to characterize the biosynthesized nanoparticles. As a result of the characterization, the spectra showed that a spectrum at a wavelength of about 419 nm and a spherical size of 38 nm nanoparticles was formed. Antibacterial …
The Single Nucleotide Ss-Arrestin2 Variant, A248t, Resembles Dynamical Properties Of Activated Arrestin, Özge Şensoy
The Single Nucleotide Ss-Arrestin2 Variant, A248t, Resembles Dynamical Properties Of Activated Arrestin, Özge Şensoy
Turkish Journal of Chemistry
ß-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in the field of GPCR-mediated pharmacology. However, impact of these mutations on function of these variants has remained elusive. In this study, structural and dynamical properties of one of ß-arrestin2 (arrestin 3) variants, A248T, which has been identified in some cancer tissue samples, were investigated via molecular dynamics simulations. The results showed that the variant underwent structural rearrangements which are seen in crystal structures of active arrestin. Specifically, the "short helix" unravels …
Design Of An Amphiphilic Hyperbranched Core/Shell-Type Polymeric Nanocarrier Platform For Drug Delivery, Ayça Bal Öztürk, Nesri̇n Oğuz, Hande Tekarslan Şahi̇n, Serkan Emi̇k, Emi̇ne Alarçi̇n
Design Of An Amphiphilic Hyperbranched Core/Shell-Type Polymeric Nanocarrier Platform For Drug Delivery, Ayça Bal Öztürk, Nesri̇n Oğuz, Hande Tekarslan Şahi̇n, Serkan Emi̇k, Emi̇ne Alarçi̇n
Turkish Journal of Chemistry
An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-bpoly(ε-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, $^{1}$H NMR, $^{13}$C NMR, and GPC analysis. Monodisperse HPAE-PCL-bMPEG nanoparticles with dimensions of
Arene Diazonium Saccharin Intermediates: A Greener And Cost-Effective Alternative Method For The Preparation Of Aryl Iodide, Lia Zaharani, Nader Ghaffari Khaligh, Zohreh Shahnavaz, Mohd Rafie Johan
Arene Diazonium Saccharin Intermediates: A Greener And Cost-Effective Alternative Method For The Preparation Of Aryl Iodide, Lia Zaharani, Nader Ghaffari Khaligh, Zohreh Shahnavaz, Mohd Rafie Johan
Turkish Journal of Chemistry
In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps …
An Anthracene Based Fluorescent Probe For The Selective And Sensitive Detection Of Chromium (Iii) Ions In An Aqueous Medium And Its Practical Application, Erman Karakuş
Turkish Journal of Chemistry
An anthracene based fluorescent probe, integrated with thiophene moiety, exhibited selective and sensitive detection of chromium (III) ions over other metal ions. Its synthesis was achieved by simple mixing of two commercially available compounds, 2-aminoanthracene, and 2-thiophenecarboxaldehyde, in onestep without the needed complex purification process. The probe molecule (ANT-Th) offered exceptional features such as "turn-on" fluorescence response, low detection limit (0.4 μM), and fast response time (< 1 min) via C$=$N bond hydrolysis. Also, a simple test paper system was developed for the rapid detection of chromium (III) ions with the naked eye.
Modeling And Optimization Of Simultaneous Degradation Of Rhodamine B And Acid Red 14 Binary Solution By Homogeneous Fenton Reaction: A Chemometrics Approach, Nasrin Aliasgharlou, Morteza Bahram, Pezhman Zolfaghari, Naiemeh Mohseni
Modeling And Optimization Of Simultaneous Degradation Of Rhodamine B And Acid Red 14 Binary Solution By Homogeneous Fenton Reaction: A Chemometrics Approach, Nasrin Aliasgharlou, Morteza Bahram, Pezhman Zolfaghari, Naiemeh Mohseni
Turkish Journal of Chemistry
This study aimed to propose a mathematical method to investigate and optimize the simultaneous elimination process of multiple organic pollutants using the Fenton process. Hence, the treatment of rhodamine B (RB) and acid red 14 (AR14) dyes in their binary solution was studied. Multivariate curve resolution alternating least square (MCR-ALS), a novel chemometric method, was applied along with correlation constraints to resolute the UV-Vis spectrophotometric data, enabling quantification of investigated dyes despite a high spectral overlapping. Response surface methodology was adopted to assess the model and optimize individual and interactive effects of three independent factors (Fe$^{2+}$, H$_{2}$O$_{2}$ and initial pH) …
Network Dynamics Reconstruction From Data, Deni̇z Eroğlu
Network Dynamics Reconstruction From Data, Deni̇z Eroğlu
Turkish Journal of Physics
We consider the problem of recovering the model of a complex network of interacting dynamical units from time series of observations. We focus on typical networks which exhibit heterogeneous degrees, i.e. where the number of connections varies widely across the network, and the coupling strength for a single interaction is small. In these networks, the behavior of each unit varies according to their connectivity. Under these mild assumptions, our method provides an effective network reconstruction of the network dynamics. The method is robust to a certain size of noise and only requires relatively short time series on the state variable …
Joint Modeling Of Rayleigh Wave Dispersion And H/V Spectral Ratio Using Pareto-Basedmultiobjective Particle Swarm Optimization, Ersi̇n Büyük, Ekrem Zor, Abdullah Karaman
Joint Modeling Of Rayleigh Wave Dispersion And H/V Spectral Ratio Using Pareto-Basedmultiobjective Particle Swarm Optimization, Ersi̇n Büyük, Ekrem Zor, Abdullah Karaman
Turkish Journal of Earth Sciences
Estimating the shear wave velocity and thickness of geologic units in a sedimentary structure is important for quantifying the local site effect caused by an earthquake. Inversion of the Rayleigh wave dispersion alone is sensitive to the absolute average shear wave velocity, while the H/V spectral ratio is sensitive to velocity contrasts. The solution of these models in a joint system using conventional inversion techniques suffers from difficulties while evaluating partial derivatives, dependencies to the initial model that is sometimes difficult to estimate, and trapping at a local minimum. Herein, a joint model using the Pareto optimality technique with multiobjective …
Coculture Model Of Blood-Brain Barrier On Electrospun Nanofibers, Mustafa Görkem Özyurt, Ece Bayir, Şule Doğan, Şükrü Öztürk, Ayli̇n Şendemi̇r
Coculture Model Of Blood-Brain Barrier On Electrospun Nanofibers, Mustafa Görkem Özyurt, Ece Bayir, Şule Doğan, Şükrü Öztürk, Ayli̇n Şendemi̇r
Turkish Journal of Biology
The blood-brain barrier (BBB) is a control mechanism that limits the diffusion of many substances to the central nervous system (CNS). In this study, we designed an in-vitro 3-dimensional BBB system to obtain a fast and reliable model to mimic drug delivery characteristics of the CNS. A support membrane of polycaprolactone nanofiber surfaces was prepared using electrospinning. After confirming the fiber morphology and size, endothelial cells (HUVEC) and glial cells were cultured on either side of this membrane. The model's similarity to in vivo physiology was tested with a home-designed transmembrane resistance (TR) device, with positive and negative control molecules. …
Poly (I:C)- And Doxorubicin-Loaded Magnetic Dendrimeric Nanoparticles Affect The Apoptosis-Related Gene Expressions In Mcf-7 Cells, Rouhollah Khodadust, Aktan Alpsoy, Gözde Ünsoy, Ufuk Gündüz
Poly (I:C)- And Doxorubicin-Loaded Magnetic Dendrimeric Nanoparticles Affect The Apoptosis-Related Gene Expressions In Mcf-7 Cells, Rouhollah Khodadust, Aktan Alpsoy, Gözde Ünsoy, Ufuk Gündüz
Turkish Journal of Biology
Use of nanoparticles as drug carrier vectors has great potential to circumvent the limitations associated with chemotherapy, including drug resistance and destructive side effects. For this purpose, magnetic generation 4 dendrimeric nanoparticles were prepared to carry chemotherapeutic agent doxorubicin (G:4-DOX) and immune modulator polyinosinic:polycytidylic acid [Poly(I:C)]. As previously reported, DOX and Poly(I:C) was loaded onto G4 nanoparticles (PIC-G4-DOX). Cellular internalization study using confocal microscopy demonstrated high levels of cellular internalization of PIC-G4-DOX nanoparticles by MCF-7 cells. This resulted in higher efficacy of PIC-G4-DOX nanoparticles in killing MCF-7 breast cancer cells. Alteration in the expression levels of selected genes was determined …