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Polymeric Nanoparticle-Based Electrochemical Sensor For The Detection Of Ca 125, Ceren Türkcan, Si̇nan Akgöl
Polymeric Nanoparticle-Based Electrochemical Sensor For The Detection Of Ca 125, Ceren Türkcan, Si̇nan Akgöl
Turkish Journal of Chemistry
In this paper, Cys-graft-p(HEMA) nanomaterials and a new electrochemical method were developed for determination of CA 125. Cys-graft-p(HEMA) nanomaterials were synthesized with emulsion polymerization method and modified with grafting procedure. It was determined that Cys-graft-p(HEMA) nanomaterials had 50 nm dimension and spherical morphology, and per gram polymeric material contained 0.011 mmol L-cysteine. Electrode surface was prepared step by step for electrochemical analysis with optimization process. Linear determination range was determined as 5-400 U/mL (R= 0.9935). Detection limit (LOD) was calculated as 1.87 U/mL, and quantification limit (LOQ) was determined as 5.62 U/mL. The fabricated sensor system showed good repeatability, accuracy, …
Carbon Quantum Dots And Chitosan-Based Heterogeneous Silver Catalyst For Reduction Of Nitroaromatic Compounds, Farah Sami̇r Sali̇m, İdri̇s Sargin, Gülşi̇n Arslan
Carbon Quantum Dots And Chitosan-Based Heterogeneous Silver Catalyst For Reduction Of Nitroaromatic Compounds, Farah Sami̇r Sali̇m, İdri̇s Sargin, Gülşi̇n Arslan
Turkish Journal of Chemistry
Chitosan plays a crucial role in catalysis, environmental remediation, and sustainable chemistry as a renewable and cationic polysaccharide. Chitosan-based metal catalysts are used in a broad range of chemical transformations. In the study, carbon quantum dots (CQDs) were derived from Momordica charantia fruits by microwave irradiation following a green chemistry approach. Three catalysts were designed: Ag(0)-chitosan, Ag(0)-chitosan-M. charantia fruit powder, and Ag(0)-chitosan-CQDs. The catalyst supports were prepared by stabilizing CQDs or M. charantia powder within the polymeric matrix of chitosan beads. Metallic silver particles were anchored onto glutaraldehyde cross-linked chitosan beads from the aqueous solution of silver nitrate. The …
Synthesis Optimization Of Zro2 Nanostructures For Photocatalytic Applications, Fi̇li̇z Boran, Merve Okutan
Synthesis Optimization Of Zro2 Nanostructures For Photocatalytic Applications, Fi̇li̇z Boran, Merve Okutan
Turkish Journal of Chemistry
This study aims to optimize the synthesis of semiconductor zirconia (ZrO2) nanoparticles for future photocatalytic applications in degradation of pollutants in wastewater under ultraviolet (UV) light. The synthesis procedure of ZrO2 nanoparticles was optimized by examining the effects of synthesis methods (ultrasound-assisted, hydrothermal method in an autoclave and conventional precipitation), reaction time (2, 6, 10, and 18 h), ambient pH (3, 7, 10, 13), and surfactant type (anionic, cationic, and non-ionic), on the particle size and crystal phase of the nanomaterial. The characterization of the synthesized samples was performed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray …
In Vitro Tyrosinase Inhibitory, Dna Interaction Studies, And Lc?Hrms Analysis Of Ficus Carica Leaves, Güli̇n Renda, Burak Barut, Rümeysa Ceren, Enes Aydin
In Vitro Tyrosinase Inhibitory, Dna Interaction Studies, And Lc?Hrms Analysis Of Ficus Carica Leaves, Güli̇n Renda, Burak Barut, Rümeysa Ceren, Enes Aydin
Turkish Journal of Chemistry
Turkey is the world?s leading producer of figs, a typical Mediterranean fruit. The fig, Ficus carica L. (Moraceae), has been widely cultivated since ancient times due to the nutritional value of its fruits. It was aimed to investigate the phytochemical characterization and biological properties of F. carica leaf extracts in order to determine their potential for use in the treatment of various diseases. F. carica leaves were extracted in 70% methanol at 40 °C under reflux. To obtain extracts of different polarities, the crude extract was fractionated with n-hexane, dichloromethane, and n-butanol. Phenolic content was determined using liquid chromatography?high resolution …
New Pyrimidine-N-Ss-D-Glucosides: Synthesis, Biological Evaluation, And Molecular Docking Investigations, Nuran Kahri̇man, Kivanç Peker, Vi̇ldan Serdaroğlu, Ali̇ Aydin, Burçi̇n Türkmenoğlu, Asu Usta, Nuretti̇n Yayli
New Pyrimidine-N-Ss-D-Glucosides: Synthesis, Biological Evaluation, And Molecular Docking Investigations, Nuran Kahri̇man, Kivanç Peker, Vi̇ldan Serdaroğlu, Ali̇ Aydin, Burçi̇n Türkmenoğlu, Asu Usta, Nuretti̇n Yayli
Turkish Journal of Chemistry
In this study, syntheses of new pyrimidine-coupled N-ß-glucosides and tetra-O-acetyl derivatives were carried out. All glycoconjugates were investigated in comparison with known chemotherapeutic agents in terms of their antimicrobial and anticancer functions and DNA/protein binding affinities. Spectral data showed that all glycoside derivatives were obtained by diastereoselectivity as ß-anomers. Both tested groups exhibited strong antiproliferative activity (2.29?66.84 ?g/mL), but some of them had sufficiently ideal % cytotoxicity values (10.01%?16.78%). And also all synthetic compounds exhibited remarkable antibacterial activity against human pathogenic bacteria. Binding of these compounds to CT-DNA resulted in significant changes in spectral properties, consistent with groove binding. Molecular …
Synthesis Of Copper Nano/Microparticles Via Thermal Decomposition And Their Conversion To Copper Oxide Film, Çağdaş Allahverdi̇
Synthesis Of Copper Nano/Microparticles Via Thermal Decomposition And Their Conversion To Copper Oxide Film, Çağdaş Allahverdi̇
Turkish Journal of Chemistry
Copper nano/microparticles were synthesized in octadecene at 290 °C by thermal decomposition method. Copper acetate monohydrate, stearic acid, and 1-octadecanol were used as copper precursor, capping and mild reducing agents, respectively, at the synthesis. Borosilicate glass substrates submerged into the reaction solution during the synthesis were coated by copper nano/ microparticles. Thermal decomposition and coating techniques were combined in this study. Copper nano/microparticles were thoroughly characterised via X-ray powder diffraction, X-ray photoelectron, Raman, and attenuated total reflectance-Fourier transform infrared spectroscopies, and scanning and transmission electron microscopies. The average minimum Feret?s diameter of these synthesized copper particles was measured as ~87 …
Theoretical Investigation Of Steric Effects On The S1 Potential Energy Surface Of O-Carborane-Anthracene Derivatives, Fahri̇ Alkan
Theoretical Investigation Of Steric Effects On The S1 Potential Energy Surface Of O-Carborane-Anthracene Derivatives, Fahri̇ Alkan
Turkish Journal of Chemistry
TDDFT scan calculations were performed for s-carborane-anthracene derivatives (o-CB-X-Ant where X=-H, -CH3, -C2H5 and tert-butyl or -tBu) in order to understand the interplay between the steric effects, S1 potential energy surface (PES) and photophysical properties. The results show that all systems exhibit three local minima on the S1 PES, which correspond to the emissive LE and TICT state, along with the nonemissive CT state respectively. In the case of the unsubstituted system (o-CB-H-Ant), and -CH3 and -C2H5 substituted cases, S1 PES is predicted to be quite flat for certain conformations indicating that it is possible for these systems to reach …
Exosome-Mediated Long Noncoding Rna (Lncrna) Part1 Suppresses Malignant Progression Of Oral Squamous Cell Carcinoma Via Mir-17-5p/Socs6 Axis, Yuheng Du, Yanjie Shuai, Hongling Wang, Huisheng Li, Yajing Li
Exosome-Mediated Long Noncoding Rna (Lncrna) Part1 Suppresses Malignant Progression Of Oral Squamous Cell Carcinoma Via Mir-17-5p/Socs6 Axis, Yuheng Du, Yanjie Shuai, Hongling Wang, Huisheng Li, Yajing Li
Turkish Journal of Medical Sciences
Background/aim: Exosomes derived from oral squamous cell carcinoma (OSCC) could modulate OSCC development. This study aimed to explore effects of exosome-mediated lncRNA PART1 on OSCC cells. Materials and methods: This study was performed in Tianjin Medical University Cancer Institute from February 2021 to March 2022. Bioinformatic analysis was performed on the public database GEPIA (http://gepia.cancer-pku.cn/). Exosomes isolated from cell lines squamous cell carcinoma 9 (SCC9) and Centre Antoine Lacassagne-27 (CAL27) were identified by transmission electron microscope and western blot. Exosome-mediated lncRNA PART1, microRNA-17-5p(miR-17-5p) and suppressor of cytokine signaling 6(SOCS6) RNA expressions were assessed by quantitative reverse transcription polymerase chain reaction …
Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar
Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar
Turkish Journal of Medical Sciences
Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has …
Investigation Of Igf-1, Igf-Bp3 And Igf-Bp5 Levels In Umbilical Cord Blood Of Infants With Developmental Dysplasia Of The Hip, Esra Demi̇rel, Eyüp Şenocak, Gamze Nur Ci̇mi̇lli̇ Şenocak, Ali̇ Şahi̇n, Berri̇n Göktuğ Kadioğlu, Özlem Gündüz
Investigation Of Igf-1, Igf-Bp3 And Igf-Bp5 Levels In Umbilical Cord Blood Of Infants With Developmental Dysplasia Of The Hip, Esra Demi̇rel, Eyüp Şenocak, Gamze Nur Ci̇mi̇lli̇ Şenocak, Ali̇ Şahi̇n, Berri̇n Göktuğ Kadioğlu, Özlem Gündüz
Turkish Journal of Medical Sciences
Background/aim: IGF-1 (insulin-like growth factor-1) is an important regulator of bone formation. Its deficiency has been associated with fetal growth disorders and hip dysplasia. The aim of this study was to evaluate whether IGF-1, IGF-BP3 (insulin like growth factorbinding protein 3), and IGF-BP5 levels in the umbilical cord blood can be predictive for early diagnosis of DDH. Materials and methods: Umbilical cord blood samples were collected from 860 mothers with pregnancies at high risk for DDH between October 2020 and January 2021. Mothers at 37-42 weeks of gestation, with risk factors for DDH, who delivered healthy infants were included. Blood …
What Is The Impact Of Inflammasome Mechanisms On Male Infertility?, Eser Ördek, Bülent Kati, İsmai̇l Koyuncu, Mehmet Demi̇r, İsmai̇l Yağmur, Eyyup Sabri̇ Peli̇t, Hali̇l Çi̇ftçi̇, Ercan Yeni̇
What Is The Impact Of Inflammasome Mechanisms On Male Infertility?, Eser Ördek, Bülent Kati, İsmai̇l Koyuncu, Mehmet Demi̇r, İsmai̇l Yağmur, Eyyup Sabri̇ Peli̇t, Hali̇l Çi̇ftçi̇, Ercan Yeni̇
Turkish Journal of Medical Sciences
Background/aim: Mechanisms to explain inflammation in male infertility of unknown cause are still being investigated. The inflammasome is a key regulator of innate immunity in the inflammatory response to infections. Our study aims to investigate the effects of varicocele on infertility, its relationship with antioxidant and inflammasome mechanisms, and how it could be guided in azoospermic or nonazoospermic patients. Materials and methods: A cross-sectional cohort study was conducted at the department of urology in our university hospital. Eightyeight randomly selected men aged 20-45 admitted to our hospital because of infertility between September 2019 and July 2020 were included in the …
Texture Analysis Of Multiparametric Magnetic Resonance Imaging For Differentiating Clinically Significant Prostate Cancer In The Peripheral Zone, Hali̇l Özer, Mustafa Koplay, Ahmet Baytok, Nusret Seher, Lütfi̇ Saltuk Demi̇r, Abi̇di̇n Kilinçer, Mehmet Kaynar, Serdar Göktaş
Texture Analysis Of Multiparametric Magnetic Resonance Imaging For Differentiating Clinically Significant Prostate Cancer In The Peripheral Zone, Hali̇l Özer, Mustafa Koplay, Ahmet Baytok, Nusret Seher, Lütfi̇ Saltuk Demi̇r, Abi̇di̇n Kilinçer, Mehmet Kaynar, Serdar Göktaş
Turkish Journal of Medical Sciences
Background/aim: Texture analysis (TA) provides additional tissue heterogeneity data that may assist in differentiating peripheral zone (PZ) lesions in multiparametric magnetic resonance imaging (mpMRI). This study investigates the role of magnetic resonance imaging texture analysis (MRTA) in detecting clinically significant prostate cancer (csPCa) in the PZ. Materials and methods: This retrospective study included 80 consecutive patients who had an mpMRI and a prostate biopsy for sus- pected prostate cancer. Two radiologists in consensus interpreted mpMRI and performed texture analysis based on their histopathology. The first-, second-, and higher-order texture parameters were extracted from mpMRI and were compared between groups. Univariate …
Multidrug Resistance In Pathogens Of Community-Acquired Urinary Tract Infections In Turkey: A Multicentre Prospective Observational Study, İrfan Şencan, Oğuz Karabay, Fatma Aybala Altay, Serap Süzük Yildiz, Hüsni̇ye Şi̇mşek, Meli̇h Gaffar Gözükara, Semanur Kuzi̇, Gülden Eser Karlidağ, Şafak Kaya, Gülnur Kul, Emi̇ne Türkoğlu, Büşra Ergüt Sezer, Nesi̇be Korkmaz, Si̇bel Yildiz Kaya, Merve Sefa Sayar
Multidrug Resistance In Pathogens Of Community-Acquired Urinary Tract Infections In Turkey: A Multicentre Prospective Observational Study, İrfan Şencan, Oğuz Karabay, Fatma Aybala Altay, Serap Süzük Yildiz, Hüsni̇ye Şi̇mşek, Meli̇h Gaffar Gözükara, Semanur Kuzi̇, Gülden Eser Karlidağ, Şafak Kaya, Gülnur Kul, Emi̇ne Türkoğlu, Büşra Ergüt Sezer, Nesi̇be Korkmaz, Si̇bel Yildiz Kaya, Merve Sefa Sayar
Turkish Journal of Medical Sciences
Background/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options. Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with …
Qualitative Study Of A Second Order Difference Equation, Messaoud Berkal, Juan Francisco Navarro
Qualitative Study Of A Second Order Difference Equation, Messaoud Berkal, Juan Francisco Navarro
Turkish Journal of Mathematics
In this paper, we study a second order rational difference equation. We analyze the stability of the unique positive equilibrium of the equation and prove the existence of a Neimark-Sacker bifurcation, validating our theoretical analysis via a numerical exploration of the system.
Global Existence, Asymptotic Behavior And Blow Up Of Solutions For A Kirchhoff-Type Equation With Nonlinear Boundary Delay And Source Terms, Houria Kamache, Nouri Boumaza, Billel Gheraibia
Global Existence, Asymptotic Behavior And Blow Up Of Solutions For A Kirchhoff-Type Equation With Nonlinear Boundary Delay And Source Terms, Houria Kamache, Nouri Boumaza, Billel Gheraibia
Turkish Journal of Mathematics
The main goal of this work is to study an initial boundary value problem for a Kirchhoff-type equation with nonlinear boundary delay and source terms. This paper is devoted to prove the global existence, decay, and the blow up of solutions. To the best of our knowledge, there are not results on the Kirchhoff type-equation with nonlinear boundary delay and source terms.
Wood And Leaf Remains Of Palms With Affinities To Sabal Adans., From The Middle Eocene Of Turkey, Ünal Akkemi̇k, Stanila Iamandei, Euginia Iamandei, Fi̇kret Koçbulut, Hüseyi̇n Tuncay Güner, Hakan Çeli̇k, Umut Tunç
Wood And Leaf Remains Of Palms With Affinities To Sabal Adans., From The Middle Eocene Of Turkey, Ünal Akkemi̇k, Stanila Iamandei, Euginia Iamandei, Fi̇kret Koçbulut, Hüseyi̇n Tuncay Güner, Hakan Çeli̇k, Umut Tunç
Turkish Journal of Botany
Two new fossil species based on the study of wood remains and leaf imprints from the middle Eocene Çekerek Formation (central-northern part of Turkey) are assigned to the palm family Arecaceae. Standard thin sections from the two samples of fossil wood were investigated and identified as Palmoxylon sabaloides Greguss 1969, with close xylotomical affinities to the modern genus Sabal Adans. The leaf imprints are weakly costapalmate and correspond to the genus Sabal as well. Based on the short petiole extension (costa), the leaves resemble the fossil-species Sabal lamanonis (Brongn.) Heer, 1855. This fossil-species was abundant in Paleogene strata of western …
On Chip Microfluidic Separation Of Cyclotides, Reza Didarian, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Hesam Bagheroghli, Fatma Doğan Güzel, Mohsen Farhadpour, Nasrin Lotfibakhshayesh, Hossein Hashempour, Hüseyi̇n Avci
On Chip Microfluidic Separation Of Cyclotides, Reza Didarian, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Hesam Bagheroghli, Fatma Doğan Güzel, Mohsen Farhadpour, Nasrin Lotfibakhshayesh, Hossein Hashempour, Hüseyi̇n Avci
Turkish Journal of Chemistry
Cyclotides as a cyclic peptide produced by different groups of plants have been a very attractive field of research due to their exceptional properties in biological activities and drug design applications. The importance of cyclotides as new biological activities from nature caused to attract researchers to develop new separation systems. Recent growth and development on chip-based technology for separation and bioassay especially for anticancer having sparklingly advantages comparison with common traditional methods. In this study, the microfluidic separation of Vigno 1-5 cyclotides extracted from Viola ignobilis by using polar and nonpolar forces as a liquid-liquid interaction was investigated through modified …
Promoting Antihepatocellular Carcinoma Activity Against Human Hepg2 Cells Via Pyridine Substituted Palladium Complexes: In Vitro Evaluation And Qsar Studies, Öğünç Meral, Fati̇h Mehmet Emen, Emi̇ne Kutlu, Ruken Esra Demi̇rdöğen, Nesli̇han Kaya Kinaytürk, Görkem Kismali, Şevki̇naz Doğan
Promoting Antihepatocellular Carcinoma Activity Against Human Hepg2 Cells Via Pyridine Substituted Palladium Complexes: In Vitro Evaluation And Qsar Studies, Öğünç Meral, Fati̇h Mehmet Emen, Emi̇ne Kutlu, Ruken Esra Demi̇rdöğen, Nesli̇han Kaya Kinaytürk, Görkem Kismali, Şevki̇naz Doğan
Turkish Journal of Chemistry
Bis(4-(4-nitrobenzyl)pyridine)dichloropalladium(II), [PdCl$_{2}$L$^{1}$$_{2}$], bis(2-amino-5-bromopyridine)dichloropalladium(II), [PdCl$_{2}$L$^{2}$$_{2}$], bis(2,4-dimethylpyridine)dichloropalladium(II), [PdCl$_{2}$L$^{3}$$_{2}$], bis(3,4-dimethylpyridine)dichloropalladium(II), [PdCl$_{2}$L$^{4}$$_{2}$] were prepared. The spectroscopic techniques (FT-IR and $^{1}$H-NMR, $^{13}$C-NMR) were used to characterize the compounds. Theoretical calculations were used to validate the experimental results. The LanL2DZ-based DFT/B3LYP method was used to define the most stable possible molecular structure for the complexes. Potential energy distribution analysis was performed to determine the theoretical vibration bands of the complexes. Molecular electrostatic potential maps, boundary molecular orbitals and Mulliken charge distribution were used to determine the active sites of the molecules. The interaction mechanisms between the complexes and liver cancer protein were investigated via molecular docking. …
Investigation Of The Effects Of Pesticides On 'Jonagold' Apple (Malus X Domestica) Polyphenol Oxidase Enzyme Activity, Cengi̇z Çesko, Sami̇ Gashi̇, Gülnur Arabaci, Hati̇ce Palüzar, Berat Durmi̇shi̇, Era Bruçi̇, Fjolla Vllasali̇u, Nedi̇m Özdemi̇r
Investigation Of The Effects Of Pesticides On 'Jonagold' Apple (Malus X Domestica) Polyphenol Oxidase Enzyme Activity, Cengi̇z Çesko, Sami̇ Gashi̇, Gülnur Arabaci, Hati̇ce Palüzar, Berat Durmi̇shi̇, Era Bruçi̇, Fjolla Vllasali̇u, Nedi̇m Özdemi̇r
Turkish Journal of Agriculture and Forestry
this study, the effects of a number of commonly used pesticides on the activity of the polyphenol oxidase (PPO) enzyme from pesticide-free and pesticide-applied 'Jonagold' apples were comparatively evaluated. Substrates 4-methylcatechol, pyrocatechol, pyrogallol and L-tyrosine were used to determine the substrate specificity of the PPO enzyme obtained from apple. According to the results, on the contrary, PPO enzyme from 'Jonagold' apple did not show any activity against L-tyrosine substrate which is a monophenolic substrate, the enzyme had high affinity against 4-methylcatechol, pyrocatechol and pyrogallol which are di and tri phenolic substrates. Km values of PPO enzyme obtained from pesticide-free …
Chemical Composition, Biological Activities, And Surface Tension Properties Of Melissa Officinalis L. Essential Oil, Özgür Çelebi̇, Hafize Fidan, Ivan Iliev, Nadezhda Petkova, Ivayla Dincheva, Vanya Gandova, Stanko Stankov, Albena Stoyanova
Chemical Composition, Biological Activities, And Surface Tension Properties Of Melissa Officinalis L. Essential Oil, Özgür Çelebi̇, Hafize Fidan, Ivan Iliev, Nadezhda Petkova, Ivayla Dincheva, Vanya Gandova, Stanko Stankov, Albena Stoyanova
Turkish Journal of Agriculture and Forestry
Lemon balm (Melissa officinalis L.) is a plant of the family Lamiaceae. The present study aimed to determine the chemical composition of the lemon balm essential oil grown in Northeastern Bulgaria, to perform a comparative analysis of its antimicrobial activity with that of citral, and to determine its surface tension properties. The main compounds of the essential oil (concentration above 3%) were: ß-caryophyllene (20.45%), geranial (19.74%), neral (15.81%), germacrene D (11.50%), (R)-(+)-citronellal (3.07%), and geranyl acetate (3.04%). The antibacterial activity of the essential oil was weak against the tested gram-negative and gram-positive bacteria. Exceptions were observed for Listeria monocytogenes …
Determination Of Some Quality Properties And Antimicrobial Activities Of Kombucha Tea Prepared With Different Berries, Oktay Tomar
Determination Of Some Quality Properties And Antimicrobial Activities Of Kombucha Tea Prepared With Different Berries, Oktay Tomar
Turkish Journal of Agriculture and Forestry
Kombucha is a slightly sweet, acidic, carbonated, fermented beverage obtained by fermenting sugared tea (Camellia sinesis) with symbiotic bacteria. In the present study, kombucha was produced from black tea (Camellia sinensis), black grape (Vitis labrusca), black mulberry (Morus nigra), and rosehip (Rosa canina) fruits. Its physicochemical, microbiological, sensory properties and antimicrobial effects were investigated. During the fermentation, pH, Brix (%), viscosity, total antioxidant, and phenolic substance values decreased (p < 0.05). Total aerobic mesophilic bacteria (TAMB) and yeast/mold, Lactococcus/Streptococcus counts decreased, while the osmophilic yeast, acetic acid, and lactic acid bacterial counts increased (p < 0.05). The samples produced using black mulberry had the highest antibacterial activity (26.58 mm zone diameter), lowest minimum inhibitory concentration (MIC) (0.012 mg·L$^{-1}$), and minimum bactericidal concentration (MBC) (0.008 mg·L$^{-1}$) on Staphylococcus aureus. The highest …
Cryogenic X-Ray Crystallographic Studies Of Biomacromolecules At Turkish Light Source "Turkish Delight", Necati̇ Atalay, Enver Kami̇l Akcan, Mehmet Gül, Esra Ayan, Ebru Destan, Fatma Betül Ertem Kuzucu, Nuretti̇n Tokay, Bariş Çakilkaya, Zeli̇ş Nergi̇z, Gözde Karakadioğlu Usta, Abdullah Kepceoğlu, İlki̇n Yapici, Bi̇lge Tosun, Ni̇lüfer Baldir, Günseli̇ Yildirim, J Austin Johnson, Ömür Güven, Alaleh Shafiei, Nazli Eylül Arslan, Merve Yilmaz, Cahi̇ne Kulakman, Seyi̇de Seda Paydos, Seynep Sena Çi̇nal, Kardelen Şabanoğlu, Ayşegül Pazarçevi̇ren, Ayşenur Yilmaz, Başak Canbay, Bengi̇su Aşçi, Esra Kartal, Serra Tavli, Mehmet Çaliseki̇, Günce Göç, Ari̇f Mermer, Gamze Yeşi̇lay, Sevde Altuntaş, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Şaban Teki̇n, Hali̇li̇brahi̇m Çi̇ftçi̇, Serdar Durdaği, Gi̇zem Di̇nler Doğanay, Ezgi̇ Karaca, Burcu Kaplan Türköz, Burak Veli̇ Kabasakal, Ahmet Kati, Hasan Demi̇rci̇
Cryogenic X-Ray Crystallographic Studies Of Biomacromolecules At Turkish Light Source "Turkish Delight", Necati̇ Atalay, Enver Kami̇l Akcan, Mehmet Gül, Esra Ayan, Ebru Destan, Fatma Betül Ertem Kuzucu, Nuretti̇n Tokay, Bariş Çakilkaya, Zeli̇ş Nergi̇z, Gözde Karakadioğlu Usta, Abdullah Kepceoğlu, İlki̇n Yapici, Bi̇lge Tosun, Ni̇lüfer Baldir, Günseli̇ Yildirim, J Austin Johnson, Ömür Güven, Alaleh Shafiei, Nazli Eylül Arslan, Merve Yilmaz, Cahi̇ne Kulakman, Seyi̇de Seda Paydos, Seynep Sena Çi̇nal, Kardelen Şabanoğlu, Ayşegül Pazarçevi̇ren, Ayşenur Yilmaz, Başak Canbay, Bengi̇su Aşçi, Esra Kartal, Serra Tavli, Mehmet Çaliseki̇, Günce Göç, Ari̇f Mermer, Gamze Yeşi̇lay, Sevde Altuntaş, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Şaban Teki̇n, Hali̇li̇brahi̇m Çi̇ftçi̇, Serdar Durdaği, Gi̇zem Di̇nler Doğanay, Ezgi̇ Karaca, Burcu Kaplan Türköz, Burak Veli̇ Kabasakal, Ahmet Kati, Hasan Demi̇rci̇
Turkish Journal of Biology
X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g., proteins, nucleic acids, protein complexes, protein-nucleic acid complexes, or large biological compartments). Since its inception, single-crystal cryocrystallography has never been performed in Türkiye due to the lack of a single-crystal X-ray diffractometer. The X-ray diffraction facility recently established at the University of Health Sciences, İstanbul, Türkiye will enable Turkish and international researchers to easily perform high-resolution structural analysis of biomacromolecules from single crystals. Here, we describe the technical and …
Sdf-1 Induces Directional Chemotaxis Of Endogenous Bmscs At The Intervertebral Fusion Site And Promotes Osteogenic Differentiation By Regulating Wnt/Ss-Catenin In The Bone Marrow Chimera Spinal Intervertebral Fusion Mouse Model, Qiwen Zhang, Ning Liang, Bin He, Siyou Wu, Depeng Wen, Xiaoyong Tang, Xiongcheng Shen
Sdf-1 Induces Directional Chemotaxis Of Endogenous Bmscs At The Intervertebral Fusion Site And Promotes Osteogenic Differentiation By Regulating Wnt/Ss-Catenin In The Bone Marrow Chimera Spinal Intervertebral Fusion Mouse Model, Qiwen Zhang, Ning Liang, Bin He, Siyou Wu, Depeng Wen, Xiaoyong Tang, Xiongcheng Shen
Turkish Journal of Biology
Clinical observations show that the current spinal fusion with internal fixation has a nonfusion rate of 5%-35%; however, methods to promote spinal fusion are limited. This study aimed to investigate the role of SDF-1-induced directional chemotaxis of BMSCs in bone marrow chimera spinal intervertebral fusion mouse model. BMSCs were isolated from bone marrow and identified by detecting CD44/CD34 positive cells. BMSCs (GFP-BMSCs) were labeled with GFP for tracking in vivo. Mice were inoculated with GFP-BMSCs to construct bone marrow chimera spinal intervertebral fusion model, which were divided into BM-SIF model, BM-SIF+SDF-1, BM-SIF+SDF-1-Anta group. The callus area of intervertebral fusion site …
Hydroquinidine Displays A Significant Anti-Carcinogenic Activity In Breast And Ovarian Cancer Cells Via Inhibiting Cell-Cycle And Stimulating Apoptosis, Mervenur Yavuz, Betül Şahi̇n, Ahmet Tarik Baykal, Turan Demi̇rcan
Hydroquinidine Displays A Significant Anti-Carcinogenic Activity In Breast And Ovarian Cancer Cells Via Inhibiting Cell-Cycle And Stimulating Apoptosis, Mervenur Yavuz, Betül Şahi̇n, Ahmet Tarik Baykal, Turan Demi̇rcan
Turkish Journal of Biology
Breast and ovarian cancers are women's most commonly diagnosed cancers. Seeking an efficient anticarcinogenic compound is still a top priority regarding the aggressiveness of these cancers and the limited benefit of current therapies. Hydroquinidine (HQ) is a natural alkaloid used in arrhythmia and Brugada syndrome. As an ion channel blocker, HQ exhibits its activity by altering ion gradient and membrane potential. Considering the growing evidence of ion channel blockers' antineoplastic potential, we were prompted to test HQ's effect on breast and ovarian cancers. MCF-7 and SKOV-3 cell lines were used to inspect how HQ acts on survival, clonogenicity, migration, tumorigenicity, …
Rpi-1 (Human Dcdc2) Displays Functional Redundancy With Nephronophthisis 4 In Regulating Cilia Biogenesis In C. Elegans, Oktay İsmai̇l Kaplan
Rpi-1 (Human Dcdc2) Displays Functional Redundancy With Nephronophthisis 4 In Regulating Cilia Biogenesis In C. Elegans, Oktay İsmai̇l Kaplan
Turkish Journal of Biology
Projecting from most cell surfaces, cilia serve as important hubs for sensory and signaling processes and have been linked to a variety of human disorders, including Bardet-Biedl Syndrome (BBS), Meckel-Gruber Syndrome (MKS), Nephronophthisis (NPHP), and Joubert Syndrome, and these diseases are collectively known as a ciliopathy. DCDC2 is a ciliopathy protein that localizes to cilia; nevertheless, our understanding of the role of DCDC2 in cilia is still limited. We employed C. elegans to investigate the function of C. elegans RPI-1, a Caenorhabditis elegans ortholog of human DCDC2, in cilia and found that C. elegans RPI-1 localizes to the entire ciliary …
Astragaloside Iv Improves Renal Function And Alleviates Renal Damage And Inflammation In Rats With Chronic Glomerulonephritis, Dong Zhang, Zongying Li, Yuan Gao, Hailing Sun
Astragaloside Iv Improves Renal Function And Alleviates Renal Damage And Inflammation In Rats With Chronic Glomerulonephritis, Dong Zhang, Zongying Li, Yuan Gao, Hailing Sun
Turkish Journal of Biology
From Astragalus membranaceus (Fisch.) Bge.var. mongholicus (Bge.) Hsiao, astragaloside IV (AS-IV), a saponin can be purified and is considered traditional Chinese medicine. The purpose of this study was to evaluate the AS-IV-mediated mechanism on chronic glomerulonephritis (CGN). A cationic bovine serum albumin-induced CGN rat model was established and 10, 15, or 20 mg/kg of AS-IV was administered to measure renal function and inflammatory infiltration. Influences of AS-IV on proliferation, cell cycle, and inflammation of LPS-induced rat mesangial cells (RMCs) were determined. The results demonstrated that AS-IV alleviated renal dysfunction, renal lesions, and inflammation in CGN rats. AS-IV prolonged the G0-G1 …
A Ph-Responsive Shell-Sheddable Polymeric Nanoparticles As The Photodynamic Drug Carrier: Synthesis, Characterization, And In Vitro Studies, Jing Lu
Turkish Journal of Biology
Shell-sheddable nanoparticles, composed of amphiphilic blockpolymers, have emerged as an attractive vehicle for the site-specific delivery of therapeutic agents. In this study, pH-responsive sheddable copolymers bearing an orthoester linker were synthesized via the ring-opening polymerization between γ-benzyl-L-glutamate N-carboxyanhydride and orthoester-bearing poly (ethylene glycol) macroinitiator (PEG-pH-NH2). The obtained poly (ethylene glycol)-b-poly(γ-benzyl-L-glutamate) (PEG-PBLG) could form stable nanoparticles in aqueous solutions due to the amphiphilic nature of the block copolymers. The PEG-PBLG-based nanoparticle exhibited good stability in physiological conditions (pH 7.4), whereas the nanoparticle was disassembled under acidic conditions (pH 5.0). The nanoparticles could encapsulate a photosensitizer, protophorphyrin IX …