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Impact Of Ivermectin On Nerve Regeneration Following Sciatic Injury In Mice: The Consequences Of Dietary High Fructose, Ezgi̇ Deni̇z Arikan, Barişcan Çi̇men, Ayşe Ece Gezen Yilmaz, Eli̇f Akaydin, Berkay Alpay, Deni̇z Eki̇n Erbaş, Erblina Nikshiqi, Sevda Müftüoğlu, Yildirim Sara

Turkish Journal of Medical Sciences

Background/aimPeripheral nerve injuries (PNI) are debilitating disorders affecting predominantly the younger generation, often leading to significant disabilities. Current treatment strategies are inadequate in addressing the complex nature of these injuries. Peripheral nerve healing and functional recovery are crucial components of both pathophysiology and therapeutic approach. High fructose corn syrup (HFCS) is a frequently used sweetener in several beverages and foods. And it is associated with several metabolic disturbances including insulin resistance and may impair nerve healing. This study investigates the therapeutic role of ivermectin on nerve regeneration following sciatic nerve injury and evaluates motor and sensorial functions together with histopathological …

Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan

Turkish Journal of Medical Sciences

Background/aimCinnamon spice is obtained by drying the tree bark of the Cinnamomum Schaeff genus. Cinnamomum genus belongs to the Lauraceae family and there are approximately 250 different species around the world. The most common species in the market are Cinnamomum verum J. S. Presl, C. cassia (L.) J. Presl, C. burmannii (Nees & T. Nees) Blume and C. loureiroi Nees. Cinnamon and its by-products are used for many years for their antidiabetic effect. In this research, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to conclude whether they are safe to …

Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to investigate the genotype-phenotype correlation in Sanfilippo type B patients in terms of bone formation/resorption parameters, and to determine the release/inhibition of biomarkers accompanying osteoporosis.Materials and Methods: Plasma levels of Osteoprotegerin, Matrix metalloproteinases (MMP2, MMP9), TIMP-1, TIMP-2, BALP, Cathepsin K, and TRACP-5b were examined by ELISA method in MPS IIIB patients. At the same time, mutations in the NAGLU gene causing this disease were detected by whole exome sequencing, and their correlation with biochemical parameters was investigated.Results: Based on the enzyme analysis results, MMP-9, TIMP1, TIMP-2, and MMP-2 were significantly high, while Cathepsin-K …

Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha

Turkish Journal of Medical Sciences

Background/Aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses.

Materials and Methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion, and the effects of estradiol and ascorbic acid on nephrotoxicity were evaluated. After 4 weeks …

Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş

Turkish Journal of Medical Sciences

No abstract provided.

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Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Pharmacokinetics Of Liposomal Levamisole After Oral, Intramuscular, And Subcutaneousadministration In Sheep, Hasan Susar, İzzet Karahan

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine the pharmacokinetics of free and liposomal levamisole in sheep following single oral (O),intramuscular (IM), and subcutaneous (SC) administrations at a dose of 7.5 mg/kg. The study developed a levamisole liposome andinvestigated relevant parameters: particle size, zeta potential, polydispersity index, encapsulation efficiency, pH, and morphology. TheBangham method, a thin-film hydration technique, was employed to prepare the liposomal levamisole. Blood samples were collectedby jugular venipuncture in heparinized tubes immediately before each free and liposomal levamisole treatment and at 2.5, 5, 10, 15,30, 60, 90, 120, 240, 360, and 480 min and 12, 16, and 24 h after …

Chemical Composition And Larvicidal Toxicity Of Ricinus Communis L. (Euphorbiaceae) Extracts Against Larvae Of Thaumetopoea Pityocampa (Denis & Schiffermüller, 1775) (Lepidoptera: Notodontidae), Memi̇ş Kesdek, Şaban Kordali, Selçuk Küçükaydin

Turkish Journal of Agriculture and Forestry

In this study, the toxicities of extracts obtained from the seeds and leaves of castor bean (Ricinus communis L.) (Euphorbiaceae) plant against five larval stages of the pine processionary moth (PPM) (Thaumetopoea pityocampa (Denis & Schiffermüller, 1775) (Lepidoptera: Notodontidae)) were investigated under laboratory conditions. Petroleum ether, acetone, and methanol extracts were prepared at various concentrations (0.25, 0.5, and 1 mg/mL) and sprayed on each larval stage. Each test was performed with three replications and two repetitions. Sterile water + ethanol was used as a negative control and the commercial chemical Kormilin 25 WP (25% diflubenzuron) was used as a positive …

Phytochemical Analysis And In Vitro And In Vivo Pharmacological Activities Of Cordia Myxa Extracts, Tatheer Fatima, Mirza Imran Shahzad, Adnan Noor Shah, Zhang Yi, Bushra Gillani, Iqra Hussain, Adina Gillani, Zeli̇ha Çi̇ftçi̇, Marcello Locatelli, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary

Turkish Journal of Agriculture and Forestry

Cordia myxa is found in tropical regions of Pakistan, where it is commonly known as lasura. This study aimed to assess the preliminary results of phytochemical analysis and the pharmacological activities of C. myxa. After pulverizing the fresh plant, extracts were prepared using different solvents, including aqueous, methanol, ethanol, dichloromethane, ethyl acetate, and n-hexane extracts. These extracts were examined for total phenolic contents using standard biochemical tests and high performance liquid chromatography with a photodiode array. In further evaluations, antioxidant, antibacterial, antiviral, hen’s egg test on chorioallantoic membrane (HETCAM) assay, antipyretic, antiinflammatory, and antidiabetic activities were monitored. Using ferric reducing …

Exploring Genetic Diversity: The Inheritance Of Protein And Mineral Contents In Dwarf Common Beans, Ercan Ceyhan, Ayşegül Korkmaz, Amjad Ali̇, Serdar Karadaş, Mustafa Harmankaya, Duran Şi̇mşek, Tolga Karaköy

Turkish Journal of Agriculture and Forestry

Beans are a vital plant-based protein, containing essential minerals that are necessary for human health. Their protein and mineral compositions vary due to factors including cultivar or variety, growth conditions, and processing methods. Global deficiencies in protein and minerals necessitate fortification, supplementation, and dietary diversification. The present study focuses on common bean (Phaseolus vulgaris) cultivars, aiming to understand their genetic variation and inheritance of protein and mineral contents. Five dwarf common bean cultivars (Lida, Beyzade, Ribera, Albeni, and Garrafol) were used in a full-diallel hybridization method and the experiment was conducted in Konya, Türkiye. The diallel analysis assessed both general …

Nutritional And Microbiological Properties Of Cheese With Dried Elderberry And Red Grape Pomace, Andreea Dodan, Romina Alina Marc, Crina Carmen Mureşan, Carmen Rodica Pop, Delia Michiu, Miuța Rafila Filip, Roxana Nicoleta Rațu, Florina Stoica, Ioana Cristina Crivei, Alina Narcisa Postolache, Melinda Kovacs, Rodica Maria Sima, Mircea Valentin Muntean

Turkish Journal of Agriculture and Forestry

This study aimed to explore the use of grape byproducts such as red grape pomace and elderberry, in the form of bioactive powders to obtain three-month old cheese assortments. Grape pomace powder (GPP) and elderberry fruit powder (EFP) contain antioxidant components such as phenols, anthocyanins and flavonoids, and compounds characterized by high bioactivity. This study investigated not only the potential of incorporating different percentages (1%, 2%, and 3%) of GPP and EFP in cheese, to increase its nutritional value, but also the changes that occur during the 2 months of ripening. The results indicated that the incorporation of GPP and …

Effects Of Pericarp Removal And Different Germination Conditions On Seed Germination And Saline-Alkali Tolerance Of Amorpha Fruticosa, Zhan-Wu Gao, Yong-Guang Mu, Feng Chen, Li-Jie He, Xin-Ning Li, Jia-Tong Li, Ke-Jia Ding, Yan-Hui Cu, Chun-Sheng Mu, Adnan Rasheed

Turkish Journal of Botany

In this paper, neutral salt NaCl and basic salt Na2CO3 were used to simulate salt stress and alkali stress respectively, and the effects of salt stress and alkali stress on seed germination and growth changes in natural saline-alkali soil were studied, in order to provide theoretical basis for making full use of plant resources and improving production efficiency. The fruit peel of Amorpha fruticosa contains a lot of lipids, which has a significant effect on seed germination. Under salt stress, removal of pericarp significantly increased germination rate, germination potential and germination index (P< 0.05), and significantly shortened germination time of seeds (p< 0.05), which accelerated the establishment of seedlings, reduced the stress time during germination, and advanced the transition from heterotrophic to autotrophic, accumulating more anions and organic solutes to adapt to salt stress. Therefore, when planting in neutral salt soil, it can be used to remove the peel for sowing to improve the planting effect. However, under alkali stress, the growth is inhibited by the absorption of a large amount of Na+ and high pH value, so it is not suitable for removing the peel for sowing. Different germination conditions had significant effects on seed germination. The length and biomass of radicle and germ in sand culture were significantly higher than those in paper culture (P< 0.05). Under the condition of sand culture, the concentration of the treatment solution can be well maintained, which is conducive to fixing the seedlings and reducing the interference of other mineral elements. Therefore, sand culture method is recommended for seed germination experiments under stress, especially for plants with developed roots.

Impact Of Anoxygenic Phototrophic Bacteria On The Growth Of Arabidopsis Thaliana Under Salt Stress, Behi̇ye Nur Aksoy, Hamza Ettadili, Caner Vural

Turkish Journal of Botany

The effect of a microbial mixture containing anoxygenic phototrophic bacteria (APB) on the growth of Arabidopsis thaliana ecotype Col-0 under salt stress was investigated. To induce salt stress, 150 mM NaCl was applied to A. thaliana. Four treatments were employed to assess the impact of APB: (1) control plants, (2) plants inoculated with a mixture of enriched photosynthetic bacteria, (3) plants inoculated with a mixture of enriched photosynthetic bacteria and irrigated with 150 mM NaCl solution, and (4) plants irrigated with 150 mM NaCl solution. The analysis demonstrated that the inoculated plants exhibited increased leaf formation and leafsize. Furthermore, an …

Acetylcholine Treatments Enhance Growth, Photosynthesis Efficiency And Stress Resilience In Maize Seedlings Exposed To Arsenic, Büşra Arikan-Abdulveli

Turkish Journal of Botany

Arsenic (As) is a widespread and highly toxic metalloid that adversely affects plant health, leading to reduced yields, impaired photosynthesis, and compromised root structures. Although acetylcholine (ACh), a neurotransmitter implicated in plant growth and stress responses, has shown potential in mitigating heavy metal stress, its effects on As stress in maize (Zea mays L.) remain largely unexplored. This study investigated the impact of ACh treatments on maize seedlings exposed to As stress (100 µM), focusing on physiological responses, growth rates, photosynthesis, and the antioxidant system. Our findings revealed that ACh treatments conferred differential protective effects against As stress. The lowest …

A Study Of The Dormant Period Of Thaumetopoea Pityocampa (Lepidoptera: Notodontidae) In Bulgaria, Gergana Zaeмdzhikova, Md Habibur Rahman Salman

Turkish Journal of Zoology

The pine processionary moth (PPM), Thaumetopoea pityocampa (Denis et Schiffermuller), is a significant pest affecting conifer forests in the Mediterranean region. This study investigated the diapause mechanisms and survival strategies of PPM in summer and winter feeding populations in Bulgaria. The research was conducted from February to April 2021 at five pine plantation sites known for T. pityocampa activity in southwest Bulgaria. Herein, 1224 specimens were collected across different developmental stages. The sampled populations included those exhibiting typical winter feeding as well as atypical summer feeding. Morphological assessments and monitoring of the development of the individuals were conducted under controlled …

Testing And Optimizing Methodologies For Microplastic Extractions From Owl Pellets, Merve Seyfe, Meli̇ke Seyfe, Tolga Kankiliç, Ülkü Ni̇han Tavşanoğlu

Turkish Journal of Zoology

Microplastic pollution is a pressing global environmental concern, potentially threatening ecosystems and entering the food chain. Owls, as nocturnal carnivorous birds, are at significant risk of ingesting microplastics due to their diverse foraging habits. This study aimed to identify the most suitable procedure for extracting microplastics from owl pellets, focusing on efficiency, functionality, and cost and ensuring the extraction of both prey and microplastics without damage. Experiments were conducted on pellets from long-eared owl (Asio otus) collected from three different habitats in Ankara, Türkiye. The extraction of microplastics was then tested using various treatments (n = 25), involving different durations, …

The Effects Of Active Substances Of Clinically Important Drugs On The Survival, Development, And Some Adult Traits Of Drosophila Melanogaster Meigen (Diptera: Drosophilidae), Gökçe Üstündağ, Kemal Büyükgüzel, Ender Büyükgüzel

Turkish Journal of Zoology

Drosophila melanogaster Meigen (Diptera: Drosophilidae) was used as a model organism and fed on an artificial diet with different clinically important drugs under laboratory conditions. The effects of fluconazole, acyclovir, and piperazine on the survivorship, development, adult longevity, fecundity, and hatching rate of the insect were investigated. The results showed that the highest concentration of fluconazole (1250 mg/L) significantly decreased both the rate of larvae reaching the 3rd instar and the rate of pupation from 93.00 ± 2.95% to 11.00 ± 2.59% (χ2 = 134.696; df = 1; p = 0.0001). The highest concentration of acyclovir (200 mg/L) significantly reduced …

Differentiation Of Mullus Barbatus And Mullus Surmuletus (Perciformes, Mullidae) From Turkish Waters Of The Mediterranean Sea Using Otolith Shape Analyses, Semra Saygin

Turkish Journal of Zoology

Red mullet (Mullus barbatus) and surmullet (Mullus surmuletus) are valuable components of the commercial fishery industry in the Mediterranean Sea in Türkiye. To date, morphological and genetic characteristics have been used to distinguish these species. This study aimed to determine whether it was possible to distinguish between the two species using the morphometric features of their sagittal otoliths. Sagittal otoliths were subjected to elliptic Fourier analysis, wavelet analysis, and analysis of otolith shape indices for 117 specimens from the Mediterranean Sea coast of Türkiye (Mullus barbatus: 53 individuals; Mullus surmuletus: 64 individuals). Overall, canonical discriminant analysis (CDA) demonstrated strong discrimination …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Characterization Of The Biofilm-Forming Ability And Certain Virulence Characters Ofaeromonas Spp. Isolates From Rainbow Trout, Türker Çelebi̇, Ertan Emek Onuk, Esra Demi̇rbaş, Gökçen Di̇nç

Turkish Journal of Veterinary & Animal Sciences

Aeromonas spp., commonly found in the aquatic environment, cause infections in both fish and humans. Their pathogenicitydepends on various virulence factors and ability to form biofilm. The current study aimed to determine the biofilm-forming capabilitiesand certain virulence characteristics of 25 Aeromonas spp. isolates obtained from rainbow trout in Türkiye. The biofilm-forming abilitiesof isolates were investigated comparatively using Congo red agar (CRA), the tube method (TM), and tissue culture plates (TCPs).Potential virulence factors, including hemolytic activity, gelatinase production, serine protease activity, DNase activity, and motility,were evaluated using phenotypic tests. Additionally, the distribution of four known virulence genes, namely aerA, exu, fla, …

Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol

Turkish Journal of Veterinary & Animal Sciences

Organic acids (OAs) and essential oils (EOs) have several positive effects on the gut microbiota of broilers. In this study, weaimed to determine the efficacy of a blend of protected OAs and EOs [P(OA+EO)] on the growth performance and cecal microbiota ofbroiler chickens. A total of 160 Ross 308 broiler chickens, including 80 male and 80 female birds, all 1 day old, were randomly distributedbetween the control group (basal diet) and the treatment group [basal diet + 300 g/t P(OA+EO)] according to an 8-pen arrangementwith 4 replicates of 20 birds. Body weight (BW), body weight gain (BWG), feed consumption (FC), …

Effects Of Ionophore And Yeast Addition To The Diet On Starch Digestion And Rumen Andblood Parameters In Sheep With Subacute Rumen Acidosis, Şevket Evci̇, Mehmet Aki̇f Karsli, Mehmet Demi̇rci̇, Gökhan Şen

Turkish Journal of Veterinary & Animal Sciences

This study aimed to investigate the prevention of acidosis in ruminants, which causes yield and financial losses, and toevaluate the effects of feed additives on starch digestion. Four male Bafra yearling lambs with cannulated rumens were used in a 60-daystudy. Each lamb underwent 10 days of adaptation to a ration and 5 days of sampling for four different rations including a control ration(CR), monensin ration (MR), Saccharomyces cerevisiae ration (SR), and a ration with the combination of monensin and Saccharomycescerevisiae (MSR). The experiment followed a 4 × 4 Latin-square design. Dry matter intake and digestion rates were recorded as 2404 …

The Cumulative Effect Of Ellagic Acid And Carnosic Acid Attenuates Oxidative Events During Diabetic Wound Healing: In Different Applications And On Different Days, Eli̇f Naz Gürsoy, Kanuni̇ Barbaros Balabanli, Fatma Nur Tuğcu Demi̇röz, Şule Coşkun Cevher

Turkish Journal of Biology

Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds Ellagic acid and Carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats.Materials and methods: In this study, diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment. Ellagic acid and Carnosic acid combination were applied topically and oral gavage to the full-thickness excisional wounds of all animals except the control group. We investigated oxidative events by malondialdehyde, glutathione, nitric oxide, protein carbonyl, collagen spectrophotometrically, …

Cannabinoid Receptor Ligands Modulate Fibrosis And Inflammation In Idiopathicpulmonary Fibrosis: A Preliminary Study, Sevi̇l Köse, Seli̇n Önen, Merve Gi̇zer, Esi̇n Boduroğlu, Uğur Gönüllü, Petek Korkusuz

Turkish Journal of Biology

Background/aim: There is no specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF). Therefore, new anti-inflammatory therapeutic strategies are needed. Cannabinoids (CBs) that are known for their inflammation-modulating and anti-fibrotic effects may be potential medication candidates for the treatment of IPF. Our aim is to evaluate the inflammation-modulating and anti-fibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide (LPS) stimulated human lung healthy fibroblast, epithelial cells, IPF fibroblast cells and monocytes.Materials and methods: We detected CBRs in the human lung healthy (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry (FC). We …

Development Of An Immunodiagnostic Assay For The Detection Of Sugarcane Mosaic Virus, Hafiz Muhammad Khalid, Najam Us Sahar Sadaf Zaidi, Naeem Rashid, Muhammad Tahir

Turkish Journal of Biology

Background/Aim: Sugarcane mosaic virus (SCMV; genus Potyvirus and family Potyviridae), poses a significant threat to global sugarcane cultivars, including those in Pakistan. The aim of this study was to develop a rapid and effective diagnostic tool for detection of SCMV, enabling timely implementation of control measures to mitigate potential yield losses.Materials and Methods: The study focused on the in silico analysis; physicochemical properties, immunogenicity and subcellular localization of the SCMV coat protein (CP). The SCMV coat protein (CP) gene was synthesized, cloned and expressed in Escherichia coli. The recombinant fusion coat protein (rFCP-SCMV) was purified and used to generate polyclonal …

Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n

Turkish Journal of Biology

Background: Melanoma arises from the uncontrolled multiplication of melanocytes, posing an escalating global health concern. Despite early detection and surgical removal being crucial, metastatic melanoma poses treatment challenges, with limited options like chemotherapy and immunotherapy. All-trans retinoic acid (ATRA), a natural metabolite of vitamin A, has shown promise in melanoma treatment by inducing differentiation, apoptosis, growth arrest, and immune modulation. However, ATRA treatment alone can lead to resistance and relapse. Sphingomyelin (SM) also plays a role in inhibiting melanoma progression by apoptotic cell death.Objective: This study investigated combinational anticancer effects of ATRA and SM on in vitro B16F10 melanoma cells.Method: …

Organ-On-A-Chip Platforms For Drug Development, Cellular Toxicity Assessment, And Disease Modelling, Muhammad Maaz Khurram, Göktürk Ci̇nel, Özlem Yeşi̇l Çeli̇ktaş, Erdal Bedi̇r

Turkish Journal of Biology

Organ-on-a-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to mimic organ structures onto microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions at a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that recapitulate organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to portray their versatility in investigating drug safety, efficacy, and toxicity. We also reflect upon the potential of OoCs to effectively demonstrate disease models for probable novel therapeutics, …

Mechanistic Insights Into Cardiac Regeneration And Protection Through Meis Inhibition, Aynura Mammadova, Gali̇p Servet Aslan, Li Mo, Qifang Wu, Sebastian Clauss, Fati̇h Kocabaş

Turkish Journal of Biology

MEIS1, a member of the TALE-type homeobox gene family, has emerged as a pivotal regulator of cardiomyocyte cell cycle arrest and represents a promising therapeutic target. Our study reveals that inhibition of MEIS1 using two novel small molecules, MEISi-1 and MEISi-2, significantly enhances neonatal cardiomyocyte proliferation and cytokinesis. Specifically, MEISi-1 and MEISi-2 increased the proportion of proliferating cardiomyocytes (Ph3+TnnT cells) upto 4.5 fold and the percentage of cytokinetic cardiomyocytes (AuroraB+TnnT cells) by 2 fold, compared to untreated controls. MEIS1 inhibition resulted in a notable downregulation of MEIS1 target genes and cyclin-dependent kinase inhibitors, demonstrating its effect on key regulatory pathways. …

Chelidonic Acid Abrogates Oxidative Stress And Memory Dysfunction In Experimental Aging Rats, Feri̇de Ni̇hal Si̇nan, Emel Serdaroğlu Kaşikçi, Burcu Çevreli̇

Turkish Journal of Biology

Background/aim: In an aging model established in male Wistar albino rats via the administration of D-galactose (D-gal), the aim of this study was to examine the effects of chelidonic acid on cognitive functioning and the levels of glutathione (GSH), malondialdehyde (MDA), Total antioxidant status (TAS), and brain-derived neurotrophic factor (BDNF).Materials and methods: Thirty-two Wistar albino (three month old) male rats (n = 8) were used. Group 1: Control (C), Group 2: Chelidonic acid (CA) (2 mg/kg oral gavage), Group 3: D-galactose (D-gal) (150 mg/kg, s.c.), Group 4: D-gal (150 mg/kg) + CA (2 mg/kg) (DC). Following an overnight fast, the …

Functional Characterization Of Haloarchaeal Udp-Glucose 4-Epimerase And 3-Hydroxybutyryl-Coa Dehydrogenase Genes In Nicotiana Tabacum, Çi̇ğdem Otur, Sezer Okay, Aslihan Kurt Kizildoğan

Turkish Journal of Botany

The objective of the studyAbiotic stress poses a significant threat to plant survival. In response to the challenging conditions, plants have evolved various resistance mechanisms. Recently, genetic strategies have become increasingly prevalent in efforts to enhance abiotic stress tolerance and develop stress-resistant plant varieties. In this study, we employed heterologous expression of two metabolism-related haloarchaeal genes in the Nicotiana tabacum genome to improve its mechanism for salt and drought tolerance.Experimental procedure(s)The U2642 and CL165 genes encoding 3-hydroxybutyryl-CoA dehydrogenase and UDP-glucose 4-epimerase, respectively, were subcloned into the pIPKb004 vector under the control of Cauliflower mosaic virus 35S (CaMV35S) promoter using the …