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Evaluation Of Clinical And Laboratory Characteristics And Factors Affecting Mortality In 500 Hospitalized Covid-19 Patients: A Retrospective Study, Petek Ş. Konya, Neşe Demirtürk, Derya Korkmaz, Havva Tünay, Elif Betül Koşar
Evaluation Of Clinical And Laboratory Characteristics And Factors Affecting Mortality In 500 Hospitalized Covid-19 Patients: A Retrospective Study, Petek Ş. Konya, Neşe Demirtürk, Derya Korkmaz, Havva Tünay, Elif Betül Koşar
Saudi Medical Journal
Objectives: To evaluate the clinical and laboratory characteristics of COVID-19 patients admitted to Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey, and to determine the factors affecting mortality. Methods: A total of 500 patients who were diagnosed with COVID-19 between 19th of March and 30th of September 2020 in Afyonkarahisar Health Sciences University, Faculty of Medicine, Pandemic Service, Afyonkarahisar, Turkey, were retrospectively investigated for this study. These individuals’ prognoses, demographic, clinical, laboratory, and radiological information were examined and recorded retrospectively. Comparisons were carried out between the characteristics of patients with a prognosis of death and those who recovered. Results: Of the 500 …
Correlation Between Plasma Glutathione Peroxidase 4 And N-Acetylneuraminic Acid Levels With Clinical Risk Stratification And Prognosis Of Patients With Acute Coronary Syndrome, Miao-Nan Li, Bing-Wei Bao, Ding Si-Yu, Ji Chun-Fei, Shi Xiao-Jun, Gao Da-Sheng, Gao Qin, Wang Hong-Ju
Correlation Between Plasma Glutathione Peroxidase 4 And N-Acetylneuraminic Acid Levels With Clinical Risk Stratification And Prognosis Of Patients With Acute Coronary Syndrome, Miao-Nan Li, Bing-Wei Bao, Ding Si-Yu, Ji Chun-Fei, Shi Xiao-Jun, Gao Da-Sheng, Gao Qin, Wang Hong-Ju
Saudi Medical Journal
Objectives: To investigate the correlation between plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) with clinical risk stratification and outcomes of acute coronary syndrome (ACS) patients. Methods: Between October 2018 and July 2019, 413 patients that were scheduled for coronary angiography were enrolled in this prospective study at the First Affiliated Hospital of Bengbu Medical College, Bengbu, China. Patients were divided into control and ACS groups. Patients with ACS were divided into 3 risk levels based on their thrombolysis in myocardial infarction risk score. After discharge, ACS patients were followed for the incidence of major adverse cardiac events (MACEs). …
Prevalence Of Carbapenemase Genes Among Multidrug-Resistant Pseudomonas Aeruginosa Isolates From Tertiary Care Centers In Southern Thailand, Phanvasri Saengsuwan, Narongdet Kositpantawong, Soontara Kawila, Wichien Patugkaro, Chonticha Romyasamit
Prevalence Of Carbapenemase Genes Among Multidrug-Resistant Pseudomonas Aeruginosa Isolates From Tertiary Care Centers In Southern Thailand, Phanvasri Saengsuwan, Narongdet Kositpantawong, Soontara Kawila, Wichien Patugkaro, Chonticha Romyasamit
Saudi Medical Journal
Objectives: To assess the prevalence of carbapenemase genes among multidrug-resistant Pseudomonas aeruginosa ( P. aeruginosa ) isolates from tertiary care centers in Southern Thailand. Methods: The prevalence of carbapenemase genes in P. aeruginosa isolates collected from patients hospitalized between 2015-2017 in 2 tertiary care hospitals in Songkhla Province, Southern Thailand, was investigated. Standard laboratory procedures were followed and disk diffusion test was used for bacterial identification and susceptibility evaluations. Carbapenemase genes were detected using multiplex polymerase chain reaction (PCR) and genotyping by pulsed field gel electrophoresis. Results: Among the 289 P. aeruginosa isolates, 55% was from sputum, 19.4% was from …
Who Makes New Recommendations For Ebola Treatments, Calls For Improved Access
Who Makes New Recommendations For Ebola Treatments, Calls For Improved Access
Saudi Medical Journal
No abstract provided.
The Prevalence Of Multiple Drug Resistant Urinary Tract Infections: A Single-Centered, Observational Retrospective Study In King Abdulaziz Specialized Hospital, Taif, Saudi Arabia, Faisal K. Alhomayani, Naif M. Alazwari, Mohammed S. Alshhrani, Ali S. Alkhudaydi, Abdullah S. Basaba, Tariq M. Alharthi, Muhanad M. Alghamdi, Abdulaziz S. Aljuaid, Nasser M. Alosimi, Abdulmajeed M. Alqethami
The Prevalence Of Multiple Drug Resistant Urinary Tract Infections: A Single-Centered, Observational Retrospective Study In King Abdulaziz Specialized Hospital, Taif, Saudi Arabia, Faisal K. Alhomayani, Naif M. Alazwari, Mohammed S. Alshhrani, Ali S. Alkhudaydi, Abdullah S. Basaba, Tariq M. Alharthi, Muhanad M. Alghamdi, Abdulaziz S. Aljuaid, Nasser M. Alosimi, Abdulmajeed M. Alqethami
Saudi Medical Journal
Objectives: To determine the prevalence and patterns of antibiotic resistance, risk factors, and appropriate empiric therapy for multidrug-resistant Enterococcus (MDRE) urinary tract infections (UTIs) at King Abdulaziz Specialist Hospital (KAASH), Taif, Saudi Arabia. Methods: All patients attending KAASH with MDRE UTIs between January 2018 and December 2020 were enrolled in the study. After ethical approval, data were analyzed. Results: The most common causative organisms were Gram-negative and anaerobes, and the most sensitive antibiotics were ciprofloxacin and ceftriaxone. Conclusion: Based on our analyses, regular culture and sensitivity should be made routine to gather information regarding susceptibility patterns, thereby reducing drug resistance …
False-Positive Xpert® Xpress Sars-Cov-2 Assay In An Emergency Room And Trauma Center: A Retrospective Chart Review Study, Hyerim Kim, Soeun Jeon, Sun Hack Lee, Hyun-Su Ri, Hyeon-Jeong Lee, Jeong-Min Hong, Sung In Paek
False-Positive Xpert® Xpress Sars-Cov-2 Assay In An Emergency Room And Trauma Center: A Retrospective Chart Review Study, Hyerim Kim, Soeun Jeon, Sun Hack Lee, Hyun-Su Ri, Hyeon-Jeong Lee, Jeong-Min Hong, Sung In Paek
Saudi Medical Journal
Objectives: To review reports false-positive Xpert results in an emergency room and trauma center. Methods: Patients’ data with false-positive Xpert results from November 2020 to February 2022 at Pusan National University Hospital, Busan, Republic of Korea, were extracted from the electronic medical records. Results: The positive predictive value of Xpert was 40%. Of the 12 patients with false-positive results, 5 (41.7%) were re-positives (such as, patients recovered from coronavirus disease-19 [COVID-19]), and 4 (33.3%) had head or facial trauma. Two out of 4 head or facial trauma cases had documented sample contamination with blood. Conclusion: We found a high incidence …
Evaluation Of Hematological Parameters And Thrombocytopenia Following Pfizer-Biontech (Bnt162b2) Sars-Cov-2 Vaccination, Abdullah Algaissi, Edrous Alamer, Mohammed Jeraiby, Abeer Alomaish, Omer Elrhima, Sultan Qumayi, Naaif A. Qasir, Halima Areeshi, Asma Masmali, Abdulaziz Alhazmi
Evaluation Of Hematological Parameters And Thrombocytopenia Following Pfizer-Biontech (Bnt162b2) Sars-Cov-2 Vaccination, Abdullah Algaissi, Edrous Alamer, Mohammed Jeraiby, Abeer Alomaish, Omer Elrhima, Sultan Qumayi, Naaif A. Qasir, Halima Areeshi, Asma Masmali, Abdulaziz Alhazmi
Saudi Medical Journal
Objectives: To evaluate hematological parameters and thrombotic profiles of healthy individuals who received Pfizer-BioNTech (BNT162b2) vaccines in Saudi Arabia. Methods: Hematological parameters and the incidence of anti-platelet factor-4 (anti/PF-4) antibodies were evaluated in 40 participants who were eligible for COVID-19 vaccination in Saudi Arabia (above 18 years old) at Jazan University Hospital. These parameters were assessed at 2 different timepoints; at day 0 (the day of receiving the first dose of Pfizer- BioNTech (BNT162b2) and prior to vaccination) and 14-21 days after receiving the vaccine. Results: Among the participants, 38 (80%) were men, while 12 (20%) were women, with a …
The Trends Of Cancer Patients’ Perceptions On The Causes And Risk Factors Of Cancer Over Time, Abdul Rahman Jazieh, Mohammad Alkaiyat, Khadega A. Abuelgasim, Husam Ardah
The Trends Of Cancer Patients’ Perceptions On The Causes And Risk Factors Of Cancer Over Time, Abdul Rahman Jazieh, Mohammad Alkaiyat, Khadega A. Abuelgasim, Husam Ardah
Saudi Medical Journal
Objectives: To evaluate patients’ perceptions on the causes and outcomes of cancer and the changes observed over a decade (2006-2016) at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Methods: Patients diagnosed with cancer and treated at King Abdulaziz Medical City, Riyadh, Saudi Arabia, were enrolled in a cross-sectional study. The patients were enrolled in 2 cohorts: cohort 1 from 2006-2008 and cohort 2 from 2016-2018. The trends of the perceptions related to the causes and outcomes of cancer were compared between the 2 cohorts. Results: In total, 1416 patients were enrolled in the 2 cohorts: cohort 1 included 464 patients …
Immune Complex-Mediated Glomerulonephritis Post Covid-19 Vaccination In A Patient With Concomitant Brucellosis, Saad Al Bakr, Mufaddal A. Alaithan
Immune Complex-Mediated Glomerulonephritis Post Covid-19 Vaccination In A Patient With Concomitant Brucellosis, Saad Al Bakr, Mufaddal A. Alaithan
Saudi Medical Journal
COVID vaccinations have been an important step in controlling the COVID-19 pandemic. Despite the fact they were generally safe and effective, a few case reports of renal disorders have been published following COVID vaccines. We report a 29-year-old man with history of Chronic Kidney Disease who presented to our center with flank pain after receiving AstraZeneca COVID vaccine. He also had history of raw milk ingestion. His initial investigations showed high creatinine with high level of proteinuria. A renal biopsy was consistent with immune complex-mediated glomerulonephritis on top of renal fibrosis. His brucella serology also showed high titer. He was …
Apgar Values Lower Than 7 Associated With Mortality In Premature Newborns: A Retrospective Study, Nayeri Reyes-Saavedra, Patricia C. Castelán-Villagrana, Ivette Mata-Maqueda, Juan C. Solís-Sáinz
Apgar Values Lower Than 7 Associated With Mortality In Premature Newborns: A Retrospective Study, Nayeri Reyes-Saavedra, Patricia C. Castelán-Villagrana, Ivette Mata-Maqueda, Juan C. Solís-Sáinz
Saudi Medical Journal
Objectives: To determine the risk factors associated with mortality in premature newborns (PNB). Methods: An observational, descriptive, and retrospective study, carried out at the General Hospital of San Juan del Rio, Queretaro, Mexico. The medical records of PNB admitted to the Neonatal Intensive Care Unit from January until December 2018 were studied. Results: A total of 136 PNB were included (74 males and 62 females) of whom 16 (11.7%) died (9 males and 7 females). A correlation was observed between gestational age and birth weight with Apgar values at 1 and 5 minutes (r=0.37, p <0.001). A lower birth weight was found in premature infants with infectious diseases, as well as a lower gestational age in relation to respiratory diseases ( p <0.0001). The PNB with Apgar values lower than 7 points at 1 and 5 minutes were more likely to die ( p <0.0001). The PNB with very low birth weight (1-1.49 kg), with less than 28 weeks of gestation, and with infectious pathology showed more probabilities of dying ( p <0.05). Conclusion: Apgar values lower than 7 points in the PNB are associated with the presence of infectious diseases and mortality. Likewise, a lower gestational age represents a lower birth weight, with a higher risk for respiratory and infectious diseases, and consequently an elevated mortality.
Emphasizing The Link Between Blood Types In Multi-Ethnic Disparities And Covid-19 Infection In Makkah, Saudi Arabia, Wesam A. Nasif, Abeer S.E. Ali, Asim A. Khogeer, Mohammed H. Mukhtar, Mohamed M. Noureldein, Ahmed Y. Shebly, Shumukh H. Alqahtani, Yahya A. Alnashri, Ghaidaa E. Khouj, Ziyad I. Gadah, Mohammad A. Althubiti
Emphasizing The Link Between Blood Types In Multi-Ethnic Disparities And Covid-19 Infection In Makkah, Saudi Arabia, Wesam A. Nasif, Abeer S.E. Ali, Asim A. Khogeer, Mohammed H. Mukhtar, Mohamed M. Noureldein, Ahmed Y. Shebly, Shumukh H. Alqahtani, Yahya A. Alnashri, Ghaidaa E. Khouj, Ziyad I. Gadah, Mohammad A. Althubiti
Saudi Medical Journal
Objectives: To analyze the impact and distribution of blood groups in different ethnicities and the extent of susceptibility to infection with COVID-19 in Makkah, Saudi Arabia. Methods: A retrospective study was performed on 4,609 COVID-19 patients from five ethnic groups to assess the impact and distribution of different blood types and susceptibility to COVID-19 infection. The study was carried out between November 2020 and June 2021 in the College of Medicine, Umm Al-Qura University in collaboration with the General Directorate of Health Affairs, Makkah, Saudi Arabia. Results: Blood group (A, B, and O) distributions in 2,617 COVID-19 patients with local …
Childhood Nephrolithiasis And Nephrocalcinosis Caused By Metabolic Diseases And Renal Tubulopathy: A Retrospective Study From 2 Tertiary Centers, Jameela A. Kari, Mohamed A. Shalaby, Faiza A. Qari, Amr S. Albanna, Khalid A. Alhasan
Childhood Nephrolithiasis And Nephrocalcinosis Caused By Metabolic Diseases And Renal Tubulopathy: A Retrospective Study From 2 Tertiary Centers, Jameela A. Kari, Mohamed A. Shalaby, Faiza A. Qari, Amr S. Albanna, Khalid A. Alhasan
Saudi Medical Journal
Objectives: To study childhood nephrolithiasis and nephrocalcinosis caused by metabolic disorders, distal renal tubular acidosis (dRTA), and familial hypomagnesemia, hypercalciuria, and nephrocalcinosis (FHHNC). Methods: We retrospectively evaluated 86 children presented over 10 years (2011-2021), with nephrolithiasis (89%) and nephrocalcinosis (11%) caused by metabolic disorders (62%), FHHNC (21%), and dRTA (17%). Results: The mean age at discovery was 72.7 months. The underlying metabolic etiologies included hyperoxaluria (38%), cystinuria (32%), hypercalciuria (24%), and hyperuricosuria (6%). Genetic testing was carried out for 23 patients. Hyperoxaluria was typically treated medically (75%). However, the majority progressed to end-stage kidney disease (ESKD). Most children with cystinuria, …
Emotional Responses And Coping Strategies Of Medical Students During The Covid-19 Pandemic, Sayyada Ifrah Naaz, Rana M. Hussein, Hiba B. Khan, Mohamed M. Hussein, Shoukat A. Arain
Emotional Responses And Coping Strategies Of Medical Students During The Covid-19 Pandemic, Sayyada Ifrah Naaz, Rana M. Hussein, Hiba B. Khan, Mohamed M. Hussein, Shoukat A. Arain
Saudi Medical Journal
Objectives: To assess the emotional responses and coping strategies of medical students during the lockdown and social distancing measures implemented during the coronavirus disease -19 (COVID-19) pandemic. Methods: This cross‑sectional study is based on data collected from undergraduate medical students at the College of Medicine, Alfaisal University Riyadh, Saudi Arabia, during the fall semester of academic year 2020-2021. All the participants completed a self-administered online questionnaire consisting of 3 parts: demographic information, emotional response scale, and 14-item, adapted brief coping orientation to problems experienced inventory to determine the use of avoidant or approach coping strategies. Coping and emotional response scores …
Bacteria Profiles And Risk Factors For Proven Early-Onset Sepsis In Preterm Neonates, Jingwen Hu, Xiaosong Qin
Bacteria Profiles And Risk Factors For Proven Early-Onset Sepsis In Preterm Neonates, Jingwen Hu, Xiaosong Qin
Saudi Medical Journal
Objectives: To fill this gap in the literature and establish a prediction model. Methods: This retrospective study was conducted in a Neonatal Intensive Care Unit between April 2018 and April 2019. Sixty-five sepsis cases were clinically diagnosed with early-onset neonatal sepsis (EONS) and confirmed by bacterial culture, and 91 newborns were enrolled as control. Multivariate analysis was used to analyze the data, and the predictive efficiency of the prediction model was verified using the Hosmer-Lemeshow goodness-of-fit test and receiver operating characteristic (ROC) curve. Results: There were differences in multiple gestation birth, cesarean section, gestational age, birth weight, Apgar scores at …
Skin And Soft Tissue Infections In Hospitalized Cancer Patients: A Retrospective Study, Huda M. Al-Mutairi, Oluwaseun Egunsola, Afaf Almutairi, Salha M. Al-Dossary, Rana S. Alshammasi, Dalal S. Al-Dossari, Sheraz Ali
Skin And Soft Tissue Infections In Hospitalized Cancer Patients: A Retrospective Study, Huda M. Al-Mutairi, Oluwaseun Egunsola, Afaf Almutairi, Salha M. Al-Dossary, Rana S. Alshammasi, Dalal S. Al-Dossari, Sheraz Ali
Saudi Medical Journal
Objectives: To assess the clinical and epidemiological characteristics of hospitalized cancer patients with skin and soft-tissue infections (SSTIs). Methods: An observational retrospective study was conducted between March 2016 and December 2020 at the Oncology Department of King Saudi Medical City, Riyadh, Saudi Arabia. Patients with complicated and uncomplicated SSTIs were included. Results: A total of 204 cancer patients with SSTIs were evaluated. The incidence of SSTIs was 1.67% (204/12,203). Breast cancer (39%) was the most common solid tumor in all patients with SSTIs. Exit site infection (n=84, 41.2%) was the most common SSTI in cancer patients, followed by wound infection …
The Epidemiology And Incidence Of Dengue In Makkah, Saudi Arabia, During 2017-2019, Sami Melebari, Rowaida Bakri, Abdul Hafiz, Fadel Qabbani, Asim Khogeer, Ismail Alharthi, Sultan Alhazmi, Yehya Almalki, Rasha Bulkhi, Razaz Gammash, Ashwaq Hakim, Ahmed Alkhyami, Mohamed Bazaid, Thanaa Mohammad
The Epidemiology And Incidence Of Dengue In Makkah, Saudi Arabia, During 2017-2019, Sami Melebari, Rowaida Bakri, Abdul Hafiz, Fadel Qabbani, Asim Khogeer, Ismail Alharthi, Sultan Alhazmi, Yehya Almalki, Rasha Bulkhi, Razaz Gammash, Ashwaq Hakim, Ahmed Alkhyami, Mohamed Bazaid, Thanaa Mohammad
Saudi Medical Journal
Objectives: To study the epidemiology of dengue incidence and understand the dynamics of dengue transmission in Makkah, Kingdom of Saudi Arabia (KSA), between 2017-2019. Methods: This is a cross-sectional study. Health and demographic data was obtained for all confirmed dengue cases in Makkah, KSA, in the years 2017-2019 from the Vector-Borne and Zoonotic Diseases Administration (VBZDA) in Makkah and the Makkah Regional Laboratory, KSA. In addition, entomological data about Aedes density was obtained from the VBZDA. Descriptive epidemiological methods were used to determine the occurrence and distribution of dengue cases. Results: Laboratory-confirmed dengue cases were higher in 2019 as compared …
Sars-Cov-2 Seroprevalence Among Healthcare Workers From A Tertiary Care Center In Riyadh, Saudi Arabia, Abeer M. Albaadani, Eid A. Alsufyani, Mohamed I. Mursi, Mohamed H. Haris, Kiran K. Kalam, Nisreen M. Alsherbeeni, Ahmed M. Al-Rumaihi, Souad M. Alateah, Medina A. Ahmed, Moayad M. Alqurashi
Sars-Cov-2 Seroprevalence Among Healthcare Workers From A Tertiary Care Center In Riyadh, Saudi Arabia, Abeer M. Albaadani, Eid A. Alsufyani, Mohamed I. Mursi, Mohamed H. Haris, Kiran K. Kalam, Nisreen M. Alsherbeeni, Ahmed M. Al-Rumaihi, Souad M. Alateah, Medina A. Ahmed, Moayad M. Alqurashi
Saudi Medical Journal
Objectives: To calculate the seroprevalence of asymptomatic healthcare workers (HCWs) in our institution. Methods: We conducted a cross-sectional study among asymptomatic HCWs in a large hospital during the peak of the pandemic (from July to August 2020 and followed them up until February 2021) in Riyadh, Saudi Arabia. We collected the data in a Microsoft Word document after collecting a single serum sample for detection of antibodies from each participant then we compared the results statically in Microsoft Excel tables. Results: We enrolled 188 participants and measured their IgG antibodies from venous blood samples using CLIA. Six (3.2%) had positive …
Predictive Value Of Platelet To Lymphocyte Ratio And Neutrophil To Lymphocyte Ratio In Evaluating Both Lung Involvement And Severity Of Patients With Coronavirus Disease 2019, Yusuf Aksu, Ali U. Uslu, Gülten Tarhan, Mustafa Karagülle
Predictive Value Of Platelet To Lymphocyte Ratio And Neutrophil To Lymphocyte Ratio In Evaluating Both Lung Involvement And Severity Of Patients With Coronavirus Disease 2019, Yusuf Aksu, Ali U. Uslu, Gülten Tarhan, Mustafa Karagülle
Saudi Medical Journal
Objectives: To investigate the relationship of the neutrophil lymphocyte ratio (NLR) and the platelet lymphocyte ratio (PLR) with lung involvement and total lung severity score (TLSS) in computed tomography (CT) of patients with coronavirus disease -19 (COVID-19) and to evaluate their clinical usability. Methods: Basic laboratory, clinical features and imaging data of patients was obtained by examining the file and archive records of our hospital. According to the findings of lung CT scan at the time of diagnosis among COVID-19 patients, 2 groups were formed. Results: The NLR was 2.22±11.15 and the PLR was 142.77±387.10 in patients with COVID-19 pneumonia. …
Outcomes Of Tracheostomy In Covid-19 Patients In National Guard Health Affairs, Riyadh, Saudi Arabia, Salwa Alhumaid, Mohammed A. Elkrim, Yazeed A. Aloqaili, Ghada A. Alsowailmi, Fahad A. Alobaid, Abdulaziz A. Alsalem, Mohammed A. Alqabasani, Yaseen M. Arabi, Hasan M. Aldorzi
Outcomes Of Tracheostomy In Covid-19 Patients In National Guard Health Affairs, Riyadh, Saudi Arabia, Salwa Alhumaid, Mohammed A. Elkrim, Yazeed A. Aloqaili, Ghada A. Alsowailmi, Fahad A. Alobaid, Abdulaziz A. Alsalem, Mohammed A. Alqabasani, Yaseen M. Arabi, Hasan M. Aldorzi
Saudi Medical Journal
Objectives: To evaluate coronavirus disease 2019 (COVID-19) patient tracheostomy outcomes. Methods: All COVID-19 patients at the National Guard Hospital, Riyadh, Saudi Arabia, were retrospectively recruited. Those who had tracheostomies between April and December 2020 were included. Results: The population was 45 patients, of which 30 (66.7%) were males, 15 (33.3%) were females and the mean age was 66.76±12.74 years. The tracheostomy indications were anticipated prolonged weaning in 40 (88.9%) and failed extubation in 5 (11.1%) of the patients. The mean intubation to tracheostomy duration was 20.62±7.21 days. Mortalities were high, with most attributed to COVID-19. Mortality and a pre-tracheostomy C-reactive …
Synonymous And Non-Synonymous Polymorphisms In Toll-Like Receptor 2 (Tlr2) Gene Among Complicated Measles Cases At A Tertiary Care Hospital, Peshawar, Pakistan, Muhammad Ilyas, Sumera Afzal, Saad Alghamdi, Muhammad Khurram
Synonymous And Non-Synonymous Polymorphisms In Toll-Like Receptor 2 (Tlr2) Gene Among Complicated Measles Cases At A Tertiary Care Hospital, Peshawar, Pakistan, Muhammad Ilyas, Sumera Afzal, Saad Alghamdi, Muhammad Khurram
Saudi Medical Journal
Objectives: To detect single nucleotide polymorphism in toll-like receptor 2 (TLR2) gene in complicated cases of measles, in order to understand the genetic basis of complex human immune responses against measles complications. Methods: A total of 100 children consisted of 50 measles complicated cases while rest were gender matched disease-free individuals who served as controls for this study. Patient demographic data and clinical information were recorded on a separate pre-designed model form. All exonic regions of TLR2 gene of the patients and control samples were amplified through polymerase chain reaction. Various in-silico mutation verification tools like protein variation effect analyzer, …
Risk Factor For 31-Day Unplanned Readmission To Hospital In Patients With Pulmonary Tuberculosis In China, Jing Cao, Shengpeng Liu, Juhua Huang
Risk Factor For 31-Day Unplanned Readmission To Hospital In Patients With Pulmonary Tuberculosis In China, Jing Cao, Shengpeng Liu, Juhua Huang
Saudi Medical Journal
Objectives: To evaluate risk factors associated with 31-day unplanned readmission(s) for pulmonary tuberculosis (TB) in China. Methods: This retrospective study enrolled patients (age, >14 years) with pulmonary TB who experienced 31-day unplanned readmissions to a specialized hospital for TB between January 2018 and December 2019. For each confirmed readmission, 2 control subjects were randomly selected from among patients with pulmonary TB but did not experience an unplanned readmission within 31 days. Results: A total of 402 pulmonary TB patients (5.9%) experienced unplanned readmission within 31 days after discharge. In univariate analysis, readmission was associated with gender, age, insurance coverage, residing …
The Impact Of Emergency Antibiotic Administration Time On Patients With Sepsis, Saqer M. Althunayyan, Mohammed A. Aljanoubi, Sultan M. Alghadeer, Musab Z. Alharthi, Raied N. Alotaibi, Abdullah M. Mubarak, Abdulaziz M. Almutary
The Impact Of Emergency Antibiotic Administration Time On Patients With Sepsis, Saqer M. Althunayyan, Mohammed A. Aljanoubi, Sultan M. Alghadeer, Musab Z. Alharthi, Raied N. Alotaibi, Abdullah M. Mubarak, Abdulaziz M. Almutary
Saudi Medical Journal
Objectives: To assess the mortality benefits of timely antibiotic treatment of adults present at the emergency department with sepsis and compare one-hour administration and 3-hour administration starting from the time of triage. Methods: In this retrospective study, we used secondary data analysis to investigate the utility of the National Early Warning Score as a predictor of mortality in sepsis patients between July 2018 and June 2019, at the Emergency Department, King Saud Medical City, Riyadh, Saudi Arabia. The patients were grouped into 2 based on the time interval from triage to the first antibiotic administration: the immediate group received antibiotics …
The Outcome Of Prevention Of Mother-To-Child Transmission Of Hiv Infection At King Abdulaziz University Hospital, Western Region Of Saudi Arabia: A Descriptive Study, Elaf H. Ahmed, Mayar A. Shafei, Leena S. Alsubhi, Noora A. Zarban, Bashair A. Al-Zahrani, Mohammed Shaikhomer
The Outcome Of Prevention Of Mother-To-Child Transmission Of Hiv Infection At King Abdulaziz University Hospital, Western Region Of Saudi Arabia: A Descriptive Study, Elaf H. Ahmed, Mayar A. Shafei, Leena S. Alsubhi, Noora A. Zarban, Bashair A. Al-Zahrani, Mohammed Shaikhomer
Saudi Medical Journal
Objectives: To describe the effectiveness of HIV guidelines in prevention of mother-to-child transmission (PMTCT). Methods: A retrospective review from January 2009 to December 2018 at the King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia. The main outcome measures were characteristics of HIV-exposed patients and transmission rate. Results: A total of 18 HIV-positive mothers and their 26 infants were included. The mean age of mothers at delivery was 31.69 years, and 50% were under 30 years old. All mothers received lifelong ART, except one who was not diagnosed until the 27th week of gestation. Among the mothers, 83% complied …
Early Infection In Post-Autologous Hematopoietic Stem Cell Transplant Patients: Princess Noorah Oncology Center Experience, Roaa S. Gassas, Ahmed N. Absi, Abdulrahman A. Alghamdi, Ahmed S. Alsaeed, Sameer M. Alamoudi, Ihab Y. Hemaidi, Majed D. Alahmadi, Walaa A. Rajkhan, Mannar M. Khalil, Saleem K. Dadah, Ahmed S. Higazi, Amani S. Ahmed
Early Infection In Post-Autologous Hematopoietic Stem Cell Transplant Patients: Princess Noorah Oncology Center Experience, Roaa S. Gassas, Ahmed N. Absi, Abdulrahman A. Alghamdi, Ahmed S. Alsaeed, Sameer M. Alamoudi, Ihab Y. Hemaidi, Majed D. Alahmadi, Walaa A. Rajkhan, Mannar M. Khalil, Saleem K. Dadah, Ahmed S. Higazi, Amani S. Ahmed
Saudi Medical Journal
Objectives: To assess local epidemiology and risk factors for bacterial, fungal, and viral infections among the autologous bone marrow transplant population. Methods: This study is a retrospective correlational cohort design comprising 150 adult patients who underwent autologous transplants at Princess Noorah Oncology Center, Jeddah, Saudi Arabia between 2014 and 2020. Results: The study findings indicate that bacterial infection prevalence differed significantly across the different disease status pre-salvage as patients with the relapsed disease were more likely to have bacterial infections. The median of engraftment days differed significantly between those who had a bacterial infection and those who did not. Interestingly, …
Serostatus Of Igg Antibody Against Mumps Virus In Adult Population Of Al Madinah Al Munawarah, Saudi Arabia, Waleed H. Mahallawi, Mohiadeen M. Kurdi, Nadir A. Ibrahim
Serostatus Of Igg Antibody Against Mumps Virus In Adult Population Of Al Madinah Al Munawarah, Saudi Arabia, Waleed H. Mahallawi, Mohiadeen M. Kurdi, Nadir A. Ibrahim
Saudi Medical Journal
Objectives: To determine the frequency and distribution of mumps-specific IgG antibodies among the healthy adult Saudi population in Al Madinah Al Munawarah, Saudi Arabia, where mandatory vaccination against measles-mumps-rubella (MMR) has been implemented for 30 years. Methods: Qualitative and quantitative indirect enzyme-linked immunosorbent assay was performed to determine the mumps IgG antibody levels in sera collected from 429 individuals, including 224 men and 205 women. Participants were stratified into 3 age groups according to vaccination history (<20, 21-30, and >31 years). Results: The overall seroprevalence of mumps antibodies in our population was 79.0%. The highest proportion of individuals with IgG antibody seropositivity, …
Risk Factors And Predictors That Influence Sars-Cov-2 Igg Positivity: A Cross-Sectional Study Of Blood Donors In Riyadh, Saudi Arabia, Mohammed F. Alosaimi, Abdulkarim Alhetheel, Khalid A. Aleisa, Abdullah A. Altwerki, Njoud M. Alenezy, Ebtisam M. Almutairi, Leen O. Alothaim, Khalid M. Alayed, Mohammed A. Almazyad, Turki A. Binmoammar, Fahdah A. Alshobaili, Fatimah S. Al-Shahrani, Sarah Alsubaie, Rana M. Hasanato
Risk Factors And Predictors That Influence Sars-Cov-2 Igg Positivity: A Cross-Sectional Study Of Blood Donors In Riyadh, Saudi Arabia, Mohammed F. Alosaimi, Abdulkarim Alhetheel, Khalid A. Aleisa, Abdullah A. Altwerki, Njoud M. Alenezy, Ebtisam M. Almutairi, Leen O. Alothaim, Khalid M. Alayed, Mohammed A. Almazyad, Turki A. Binmoammar, Fahdah A. Alshobaili, Fatimah S. Al-Shahrani, Sarah Alsubaie, Rana M. Hasanato
Saudi Medical Journal
Objectives: To study the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after pandemic’s peak and before the vaccine enrollment in Riyadh, Saudi Arabia and further explore predictors for SARS-CoV-2 positivity. Methods: A cross-sectional study of 515 blood donors from November 22 to December 17, 2020 was conducted at King Saud University Medical City, Riyadh, Saudi Arabia to look at SARS-CoV-2 immunoglobulin G (IgG) positivity. The participants were asked questions about their demographic characteristics, past SARS-CoV-2 infection, SARS-CoV-2-related symptoms and exposures. Results: The seroprevalence in our study was 12.2% (n=63/515). Being a non-citizen was associated with significantly higher seroprevalence …
Hspx-Mediated Survival Pathways Of Pathogenic Mycobacteria, Fahad Alhusain
Hspx-Mediated Survival Pathways Of Pathogenic Mycobacteria, Fahad Alhusain
Saudi Medical Journal
Objectives: To optimize an enzyme-linked immunosorbent assay (ELISA) for measuring the HspX protein (α-crystallin) levels and then evaluate its correlation with the accumulation of lipid bodies in Mycobacterium bovis ( M. bovis) during hypoxia and exposure to nitric oxide. Methods: This study was conducted at Prince Sultan Military Medical City, Riyadh, Saudi Arabia between 2016 and 2017. We first optimized ELISA conditions for the detection of HspX. The optimization protocol focused on minimizing concentrations of the capture antibody, detection antibody, and conjugated secondary antibody, and determining the minimum detection limit of the antigen, HspX. Bacteria were grown either in shaking …
Prevalence Of Primary Anti-Tuberculosis Drug Resistance At The Tertiary Center In Saudi Arabia And Associated Risk Factors, Mohammed S. Al-Shahrani, Majed I. Hakami, Mahmoud A. Younis, Hanan A. Fan, Mohammed A. Jeraiby, Yasser Alraey
Prevalence Of Primary Anti-Tuberculosis Drug Resistance At The Tertiary Center In Saudi Arabia And Associated Risk Factors, Mohammed S. Al-Shahrani, Majed I. Hakami, Mahmoud A. Younis, Hanan A. Fan, Mohammed A. Jeraiby, Yasser Alraey
Saudi Medical Journal
Objectives: To estimate the prevalence mono-resistant tuberculosis (MR-TB) and multidrug resistant TB (MDR-TB), and evaluate the risk factors associated with the drug-resistant tuberculosis (DR-TB). Methods: A descriptive, retrospective study was applied, utilizing the TB patients’ medical records at King Fahd Armed Forces Hospital (KFAFH), Jeddah, Saudi Arabia. The records of patients notified between 2000 and 2018 were reviewed and culture positive cases for Mycobacterium tuberculosis species were included. Moreover, the risk factors included were age, gender, smoking history, renal disease, liver disease, hyperbilirubinemia, diabetes mellitus, and human immunodeficiency virus (HIV). Results: Nine hundred and one cases in entirety were involved …
The Impact Of The Coronavirus (Covid-19) Pandemic On The Development Of Obsessive-Compulsive Symptoms In Saudi Arabia, Deemah A. Alateeq, Haneen N. Almughera, Tharaa N. Almughera, Raghad F. Alfedeah, Taeef S. Nasser, Khozama A. Alaraj
The Impact Of The Coronavirus (Covid-19) Pandemic On The Development Of Obsessive-Compulsive Symptoms In Saudi Arabia, Deemah A. Alateeq, Haneen N. Almughera, Tharaa N. Almughera, Raghad F. Alfedeah, Taeef S. Nasser, Khozama A. Alaraj
Saudi Medical Journal
Objectives: To explore the impact of the COVID-19 pandemic on the development of obsessive-compulsive disorder (OCD) symptoms and its correlation with the level of perceived stress among the Saudi population. Methods: In July 2020, a cross-sectional survey of 2909 participants in Saudi Arabia during the outbreak was conducted to collect data related to sociodemographic characteristics and scores on the Brief Obsessive-Compulsive Scale (BOCS) and Perceived Stress Scale (PSS). Results: Most participants were female (73.9%) with a university level of education or higher (81%). The prevalence of new-onset obsessions was 57.8%, compulsions 45.9%, and moderate/high perceived stress 72.4%. New-onset dirt, germs, …
Kawasaki Disease In An Infant After Administration Of Hexavalent Vaccine, Meshal Z. Almeshary, Saud A. Alanazi, Khalid M. Almoosa, Rolan K. Bassrawi
Kawasaki Disease In An Infant After Administration Of Hexavalent Vaccine, Meshal Z. Almeshary, Saud A. Alanazi, Khalid M. Almoosa, Rolan K. Bassrawi
Saudi Medical Journal
Kawasaki disease is a vascular disorder of unknown etiology that affects children. Kawasaki disease mainly involves medium-sized blood vessels and may cause cardiovascular complications, particularly coronary artery aneurysms. Concern has been raised against various types of vaccines becoming potential risk factors for Kawasaki disease. Here, we describe a case of a 4-month-old Saudi infant who presented with incomplete Kawasaki disease a few hours after receiving his hexavalent vaccine and there was a significant dilatation of all coronary arteries. Although a relationship between vaccinations and Kawasaki disease has been suggested, there is no strong evidence of an increased risk or causal …