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Articles 61 - 90 of 698
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Infected Pulmonary Hydatid Cyst: A Challenging Diagnosis, Fahad M. Alrashed, Dayel A. Alshahrani
Infected Pulmonary Hydatid Cyst: A Challenging Diagnosis, Fahad M. Alrashed, Dayel A. Alshahrani
Saudi Medical Journal
ABSTRACT Echinococcosis is a parasitic infection that is distributed worldwide. Its clinical presentation depends on the size and location of the cyst. A 7-year-old was found with a superimposed infected pulmonary hydatid cyst that was initially misdiagnosed as complicated pneumonia. Our case underscores the challenges of diagnosing and managing echinococcosis, emphasizes the need for a high index of suspicion, and describes the disease’s ability to mimic other clinical entities.
Human Papillomavirus Prevalence And Dynamics: Insights From A 5-Year Population-Based Study In Jeddah, Kingdom Of Saudi Arabia, Khalid H. Sait, Nisreen M. Anfinan, Hesham K. Sait, Hussain A. Basalamah
Human Papillomavirus Prevalence And Dynamics: Insights From A 5-Year Population-Based Study In Jeddah, Kingdom Of Saudi Arabia, Khalid H. Sait, Nisreen M. Anfinan, Hesham K. Sait, Hussain A. Basalamah
Saudi Medical Journal
Objectives: To estimate the prevalence and dynamics of human papillomavirus (HPV) infection, over a 5-year period, among Saudi women. Methods: A 2-phase, population-based study combining cross-sectional and cohort designs was carried out with 5360 ever-married women aged 30–65 from Jeddah, Saudi Arabia, between 2013 and 2018. Participants were enrolled in a designated screening program and screened using the hybrid capture 2 HPV test. Women testing positive for HPV were followed up after one year to estimate the HPV clearance rate, while those testing negative had a follow-up after 5 years to assess new HPV infections. Factors associated with HPV positivity …
Statin Use And Clinical Outcomes In Hospitalized Covid-19 Patients: A Retrospective Analysis In Riyadh, Saudi Arabia, Khalid S. Alshaalan, Rahaf F. Alkahtani, Renad F. Althobaiti, Rana A. Aldhahi, Fatimah Z. Rebh, Sarah S. Algezlan, Salma M. Alanazi, Shawg S. Alrumaih, Basma A. Alturki, Abdullah S. Alahmadi, Raneem A. Alanazi, Othman M. Alshabanah
Statin Use And Clinical Outcomes In Hospitalized Covid-19 Patients: A Retrospective Analysis In Riyadh, Saudi Arabia, Khalid S. Alshaalan, Rahaf F. Alkahtani, Renad F. Althobaiti, Rana A. Aldhahi, Fatimah Z. Rebh, Sarah S. Algezlan, Salma M. Alanazi, Shawg S. Alrumaih, Basma A. Alturki, Abdullah S. Alahmadi, Raneem A. Alanazi, Othman M. Alshabanah
Saudi Medical Journal
Objectives: To investigate the relationship between statin use and coronavirus disease-19 (COVID-19) severity. Methods: This was a retrospective study of adult patients with confirmed COVID-19 who were hospitalized at Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia. The study was carried out from July - September 2020. Antecedent statin use was evaluated using medication information available in the electronic medical records. Results: In this retrospective study, we collected data from 689 patients hospitalized with COVID-19. Among the patients, 56.2% of them were non-Saudi and 67.3% were males. The mean age of the patients was 53.7 years. The most common comorbidities …
Epidemiology Of Tuberculosis In Saudi Arabia Following The Implementation Of End Tuberculosis Strategy: Analysis Of The Surveillance Data 2015-2019, Maha M. Alawi, Haleema A. Alserehi, Ahmed O. Ali, Abeer M. Albalawi, Mashael K. Alanizi, Fatima M. Nabet, Modhi A. Alkamaly, Abdullah M. Assiri, Hani Jokhdar, Mohammed O. Qutub, Moahmmed A. Khoja, Esam I. Azhar, Wael A. Taskandi, Annes A. Sindi, Muhammad Yasir
Epidemiology Of Tuberculosis In Saudi Arabia Following The Implementation Of End Tuberculosis Strategy: Analysis Of The Surveillance Data 2015-2019, Maha M. Alawi, Haleema A. Alserehi, Ahmed O. Ali, Abeer M. Albalawi, Mashael K. Alanizi, Fatima M. Nabet, Modhi A. Alkamaly, Abdullah M. Assiri, Hani Jokhdar, Mohammed O. Qutub, Moahmmed A. Khoja, Esam I. Azhar, Wael A. Taskandi, Annes A. Sindi, Muhammad Yasir
Saudi Medical Journal
Objectives: To analyze the evolution of tuberculosis (TB) epidemiology in Saudi Arabia in the 5 years following the implementation of the end-TB Strategy. Methods: A retrospective analysis of surveillance data, reported by the national tuberculosis control program from 2015-2019, was carried out. The annual incidence and the percentage of yearly changes were calculated and compared to the World Health Organization (WHO) milestones, which anticipate a 4-5% annual decline. Additionally, various other epidemiological indicators of TB were examined. Results: The national TB incidence declined from 10.55% per 100,000 in 2015 to 8.76% per 100,000 in 2019, aligning with the WHO’s 2019 …
Efficacy And Safety Of Glecaprevir And Pibrentasvir In Saudi Patients With Chronic Hepatitis C Virus Infection At A Major Tertiary Hospital, Ali A. Ruwayni, Eman E. Alobary, Khalid M. Alyahya
Efficacy And Safety Of Glecaprevir And Pibrentasvir In Saudi Patients With Chronic Hepatitis C Virus Infection At A Major Tertiary Hospital, Ali A. Ruwayni, Eman E. Alobary, Khalid M. Alyahya
Saudi Medical Journal
Objectives: To evaluate the effectiveness and safety of glecaprevir/pibrentasvir (GLE/PIB) in chronic hepatitis C (HCV) patients, and to assess the prescribers’ adherence to Food and Drug Administration recommendations on treatment duration. Methods: A retrospective cohort study was carried out on chronic HCV patients of ≥18 years, with or without cirrhosis, naive or experienced, and with normal kidney function or chronic kidney disease (including dialysis patients) at Prince Sultan Military Medical City in Riyadh, Saudi Arabia, between February 2020 and March 2021. The primary effectiveness end-point was the number and percentage of patients who achieved a sustained virologic response (SVR12), virologic …
War And Health Crisis In Gaza, Fahdah Alokaily
War And Health Crisis In Gaza, Fahdah Alokaily
Saudi Medical Journal
No abstract provided.
Cross-Cultural Modification Of The University Of Pennsylvania Smell Identification Test For The Saudi Arabian Population: Validation And Normative Values, Saad Alsaleh, Ahmed Alhussien, Nawaf Alsubaie, Ziyad Alajlan, Sakhar Albader, Ibrahim Alarifi, Hussain Albaharna, Ibrahim Sumaily
Cross-Cultural Modification Of The University Of Pennsylvania Smell Identification Test For The Saudi Arabian Population: Validation And Normative Values, Saad Alsaleh, Ahmed Alhussien, Nawaf Alsubaie, Ziyad Alajlan, Sakhar Albader, Ibrahim Alarifi, Hussain Albaharna, Ibrahim Sumaily
Saudi Medical Journal
Objectives: To develop a reliable version of the Saudi Arabian-University of Pennsylvania smell identification test (SA-UPSIT) and to establish normative values for both genders. Methods: This cross-sectional study was carried out on voluntarily recruited normal participants in King Saud University Medical City, Riyadh, Saudi Arabia, from April 2018 to May 2023. Culture-familiar odors were chosen and the kit was translated into Arabic for the study. The test was modified 3 times in 4 versions. Following this, a random sample was collected to carry out a re-test after 6 weeks. Results: A total of 288 subjects participated in the development of …
Developing, Translating, And Validating A Survey Instrument For Assessing Hospital Food Service Staff’S Food Safety Knowledge, Perceptions, And Practices During The Covid-19 Pandemic, Nisreen M. Abdulsalam, Hajar B. Alnomani
Developing, Translating, And Validating A Survey Instrument For Assessing Hospital Food Service Staff’S Food Safety Knowledge, Perceptions, And Practices During The Covid-19 Pandemic, Nisreen M. Abdulsalam, Hajar B. Alnomani
Saudi Medical Journal
Objectives: To develop and validate a questionnaire to assess the food safety knowledge, perceptions, and practices (KPPs) of hospital food service staff (FSS) amidst the challenges of the coronavirus disease-2019 (COVID-19) pandemic. Methods: The questionnaire was subjected to a rigorous evaluation process, which included a literature review and focus groups comprising the general public, FSS, and key experts in food service. The pilot testing highlighted its utility and determined its content validity ratio (CVR). Results: Most items received high CVR scores of 0.96, indicating excellent content validity. A subsequent pilot study involved 40 FSS. Reliability testing, using Cronbach’s alpha value …
Causes Of Sleep Disturbance In Human Immunodeficiency Virus-Infected Individuals: Is It Depression Or Obstructive Sleep Apnea?, Ayşe Ö. Mete, İlkay Karaoğlan, Kübra Koçak, Begüm Şahin, Elif Yaşamali, Ali E. Kilisli, Meral Uyar
Causes Of Sleep Disturbance In Human Immunodeficiency Virus-Infected Individuals: Is It Depression Or Obstructive Sleep Apnea?, Ayşe Ö. Mete, İlkay Karaoğlan, Kübra Koçak, Begüm Şahin, Elif Yaşamali, Ali E. Kilisli, Meral Uyar
Saudi Medical Journal
Objectives: To examine the possible association of obstructive sleep apnea (OSA) and depression on sleep quality in people living with human immunodeficiency virus (PWLHIV). Methods: Adult PWLHIV were included in this prospective, cross-sectional, case-control study. Our study was completed with 99 patients and 80 control subjects. To investigate sleep quality, the Pittsburgh Sleep Quality Scale and Stanford Sleepiness Scale were used; to determine the risk of OSA, the Berlin and STOP-BANG questionnaires were used; and to evaluate the existence and degree of depression, the Beck Depression Inventory was applied. Results: Patients had significantly higher daytime sleepiness ( p =0.002) and …
The Role Of Cross-Reactive Immunity To Emerging Coronaviruses: Implications For Novel Universal Mucosal Vaccine Design, Wael Alturaiki
The Role Of Cross-Reactive Immunity To Emerging Coronaviruses: Implications For Novel Universal Mucosal Vaccine Design, Wael Alturaiki
Saudi Medical Journal
Host immune response to coronaviruses and the role of cross-reactivity immunity among different coronaviruses are crucial for understanding and combating the continuing COVID-19 outbreak and potential subsequent pandemics. This review paper explores how previous exposure to common cold coronaviruses and more pathogenic coronaviruses may elicit a protective immune response against SARS-CoV-2 infection, and discusses the challenges posed by some variants of concern that may escape current vaccines. It also highlights the need for a mucosal universal vaccine that can induce long-term protection against current and emerging coronaviruses by leveraging cross-reactive immunity. We propose a novel mucosal universal vaccine that consists …
Outcome And Complications Of Outpatient Parenteral Therapy In Pediatric Emergency Utilizing Only Peripheral Vascular Access: A Retrospective Descriptive Study, Nasser A. Haidar, Mohammed N. Alamri, Fysel L. Manthattil, Mohammed A. Alshaof, Sharaf M. Alkuhali
Outcome And Complications Of Outpatient Parenteral Therapy In Pediatric Emergency Utilizing Only Peripheral Vascular Access: A Retrospective Descriptive Study, Nasser A. Haidar, Mohammed N. Alamri, Fysel L. Manthattil, Mohammed A. Alshaof, Sharaf M. Alkuhali
Saudi Medical Journal
Objectives: To describe the cure and complication rates of outpatient parenteral therapy (OPT) utilizing only peripheral vascular access. Methods: Using a retrospective descriptive study design, we reviewed the medical charts for children aged up to 15 years old who had been discharged from the emergency department into the care of the OPT unit from January 2018 to April 2019. The primary outcomes were cure and complication rates. Results: Out of 814,150 visits, 2,788 (0.34%), accounting for 2,126 patients, were managed in the OPT unit. The majority had 2 days of symptoms, and 26.4% had comorbidities. Most patients started the treatment …
Clostridioides (Clostridium) Difficile: A Silent Nosocomial Pathogen, Ibrahim A. Al-Zahrani
Clostridioides (Clostridium) Difficile: A Silent Nosocomial Pathogen, Ibrahim A. Al-Zahrani
Saudi Medical Journal
Clostridioides difficile (C. difficile) infection is still a threat to many healthcare settings worldwide. Clostridioides difficile epidemiology has changed over the last 20 years, largely due to the emergence of hypervirulent and antimicrobial-resistant C. difficile strains. The excessive use of antimicrobials, the absence of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this pressing health issue. The prudent use of antimicrobials, particularly broad-spectrum agents, and simple infection control measures, such as hand hygiene, can significantly reduce C. difficile infection rates. Moreover, the early detection of these infections and understanding their epidemiological behavior using accurate laboratory …
Covid-19 Vaccine In Hemodialysis Patients: Time For A Boost, Waleed H. Mahallawi
Covid-19 Vaccine In Hemodialysis Patients: Time For A Boost, Waleed H. Mahallawi
Saudi Medical Journal
Objectives: To evaluate anti-spike immunoglobulin G (IgG) antibody levels of hemodialysis patients and correlate them with the patients’ demographic data and to evaluate these patients’ need for a coronavirus disease-19 (COVID-19) vaccine booster. Methods: A cross-sectional multi-center study carried out at King Abdulaziz Kidney Center, Hasan Tahir Hemodialysis Center, and Hayat Organization Hemodialysis Center in Al-Madinah Al-Munawarah, Saudi Arabia. Patients (n=167) who received a minimum single dose of COVID-19 vaccine were recruited. The samples were collected between March 2022 and January 2023. Anti-spike IgG antibody levels were measured using enzyme-linked immunosorbent assays. Results: A significantly higher proportion of patients who …
Joint Statement By Unicef Executive Director And Who Director-General On The Occasion Of World Breastfeeding Week
Saudi Medical Journal
No abstract provided.
Acinetobacter Baumannii: A Multidrug-Resistant Pathogen, Has Emerged In Saudi Arabia, Jehad A. Aldali
Acinetobacter Baumannii: A Multidrug-Resistant Pathogen, Has Emerged In Saudi Arabia, Jehad A. Aldali
Saudi Medical Journal
A significant opportunistic pathogen, Acinetobacter baumannii ( A. baumannii ) has evolved mechanisms of resistance to a wide variety of antimicrobials, including carbapenems. In this article, we assessed the prevalence, risk factors, antimicrobial sensitivity, and resistance mechanisms among A. baumannii in several locations in Saudi Arabia. Hospital-acquired infections caused by A. baumannii were prevalent in the country due to a variety of reasons, such as the high number of critically ill patients, the frequency of gastrointestinal colonization, and the widespread use of antimicrobial medications. There has been an increase in the frequency of A. baumannii strains that are resistant to …
The Usability Of Neopterin In Determining Disease Course In Covid-19, Duru Mıstanoglu Ozatag, Pınar Korkmaz, Havva Keskin, Havva Koçak
The Usability Of Neopterin In Determining Disease Course In Covid-19, Duru Mıstanoglu Ozatag, Pınar Korkmaz, Havva Keskin, Havva Koçak
Saudi Medical Journal
Objectives: To investigate the usability of neopterin in demonstrating the progression of COVID-19. As a result of uncontrolled activation of COVID-19 monocytes and macrophages, IFN gamma increases and the resulting inflammatory response causes organ damage. IFN released from T cells causes an increase in gamma neopterin levels. Therefore, measurement of neopterin levels can be used to indicate immune system activation and disease progression. Methods: The study was carried out prospectively in two different centers. The patients were divided into two groups (mild-moderate and severe) and clinical, laboratory, imaging findings and neopterin levels at hospitalization were compared. Results: 100 patients were …
Prevalence Of Extended-Spectrum Β-Lactamase And Carbapenem-Resistant Klebsiella Pneumoniae In Clinical Samples, Amela Dedeić Ljubović, Ðana Granov, Erna Husić, Džemilja Gačanović, Jasmina Halković, Azra Čamdžić Lab.Ing, Šejla Kotorić Keser, Svjetlana Loga Zec
Prevalence Of Extended-Spectrum Β-Lactamase And Carbapenem-Resistant Klebsiella Pneumoniae In Clinical Samples, Amela Dedeić Ljubović, Ðana Granov, Erna Husić, Džemilja Gačanović, Jasmina Halković, Azra Čamdžić Lab.Ing, Šejla Kotorić Keser, Svjetlana Loga Zec
Saudi Medical Journal
Objectives: To assess the prevalence of these resistant strains in the overall isolates of Klebsiella pneumoniae ( K. pneumoniae ) in hospital settings. Methods: This retrospective study was conducted from November 2020 to November 2021. The identification and antibiotic susceptibility testing were performed using standard laboratory methods according to the EUCAST standards. The detection of ESBL and carbapenemase production was performed using phenotypic methods such as E-test, combined-disk test with various inhibitors (ROSCO Diagnostica A/S), chromogenic medium for the detection of ESBL/carbapenemase-producing Enterobacteriaceae (CPE) isolates, and the VITEK 2 Compact system (BioMerieux). Results: 944 isolates of K. pneumoniae were detected …
Women And Girls Bear Brunt Of Water And Sanitation Crisis – New Unicef-Who Report
Women And Girls Bear Brunt Of Water And Sanitation Crisis – New Unicef-Who Report
Saudi Medical Journal
No abstract provided.
Using The ‘4ps’ Social Marketing Strategy To Overcome Vaccination Hesitancy: Covid-19 Vaccine Coverage In A Chinese College As An Example, Baojia Zheng, Jiao Yan, Xiaoqing Wang, Yuxin Tang, Yali Xiang
Using The ‘4ps’ Social Marketing Strategy To Overcome Vaccination Hesitancy: Covid-19 Vaccine Coverage In A Chinese College As An Example, Baojia Zheng, Jiao Yan, Xiaoqing Wang, Yuxin Tang, Yali Xiang
Saudi Medical Journal
Objectives: To explore the role of the ‘4Ps’ social marketing strategy on vaccine hesitancy and its impact on public vaccine coverage. The ‘4Ps’ strategy (place, price, product and promotion) is a social marketing tool that had addressed many public issues and vaccinations. Methods: This study was a retrospective before-after study. A total of 10795 people were enrolled. The routine COVID-19 immunization method was used for the first vaccination doses from 23 March to 11 April, 2021. Then we carried out a ‘4Ps’ social marketing strategy for vaccination from 12 April to 1 May 2021. The vaccine hesitancy and the coverage …
Assessment Of Sharps Penetrating Injury, Mucosal Exposure And Compliance With Standard Precautions Of Health Workers At A University Hospital In Turkey, Hıdır Sarı, Saim Dayan, Hüsna Balkan, Yeliz Çiçek, Mehmet Özel
Assessment Of Sharps Penetrating Injury, Mucosal Exposure And Compliance With Standard Precautions Of Health Workers At A University Hospital In Turkey, Hıdır Sarı, Saim Dayan, Hüsna Balkan, Yeliz Çiçek, Mehmet Özel
Saudi Medical Journal
Objectives: To evaluate the compliance with standard precautions in healthcare workers who experienced a sharps penetrating injury or mucosal exposure using the compliance with Standard Precautions Scale, Turkish version. Methods: This descriptive cross-sectional study was conducted in a tertiary hospital. The occupational health and safety unit records of healthcare workers who were injured by a sharps penetrating injury or experienced mucosal exposure between January 2018 and July 2020 were examined. Compliance with the Standard Precautions Scale was assessed by having participants answer a questionnaire. Results: Of the 100 participants, 59% were men. Of all healthcare workers in the university hospital, …
Systematic Review And Pooled Analysis Of Randomized Controlled Trials In Countries Of The Gulf Cooperation Council (Gcc): Methods And Quality Assessment, Khalid S. Alraddadi, Fayzah H. Al-Adwani, Rajaa M. Al-Raddadi, Sultan H. Alamri, Iman K. Ramadan, Ahmad A. Mirza
Systematic Review And Pooled Analysis Of Randomized Controlled Trials In Countries Of The Gulf Cooperation Council (Gcc): Methods And Quality Assessment, Khalid S. Alraddadi, Fayzah H. Al-Adwani, Rajaa M. Al-Raddadi, Sultan H. Alamri, Iman K. Ramadan, Ahmad A. Mirza
Saudi Medical Journal
Objectives: To describe variations in characteristics of randomized controlled trials conducted in the Gulf Cooperation Council (GCC) countries, and critically appraising the quality of design, conduct and analysis of the trials. Methods: We carried out a systematically comprehensive electronic search of articles published between 1990 and 2018 and indexed in several databases: i) MEDLINE/PubMed, ii) EMBASE, iii) Cochrane Central Register of Controlled Trials (CENTRAL), iv) ClinicalTrials.gov, and v) World Health Organization International Clinical Trials Registry Platform. We summarized the overall risk of bias present in all analyzed studies using the Cochrane Collaboration risk of bias tool (CCRBT). Results: A remarkable …
Comment On: Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Nour Al-Mozain, Maha A. Badawi, Mohammad A. Alfhili
Comment On: Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Nour Al-Mozain, Maha A. Badawi, Mohammad A. Alfhili
Saudi Medical Journal
No abstract provided.
Early Recognition Of Pulmonary Complications Of Sickle Cell Disease, Rayyan M. Almusally
Early Recognition Of Pulmonary Complications Of Sickle Cell Disease, Rayyan M. Almusally
Saudi Medical Journal
Sickle cell disease (SCD) is an inherited hematological disorder with multiple-organ involvement. The pulmonary complications of SCD are associated with significant morbidity and mortality. This article presents an important review of acute and chronic pulmonary complications, including acute chest syndrome, pneumonia, pulmonary thromboembolism, pulmonary fat embolism, chronic sickle cell lung disease, and pulmonary hypertension, in patients with SCD. Bronchial asthma and obstructive sleep apnea in relation to SCD are discussed in this article. Early recognition of pulmonary complications leads to early therapeutic interventions and improvement of the overall treatment outcome.
Clinical Manifestations Of Covid-19 Versus Other Upper Respiratory Tract Infections In Pediatric Patients, Manar M. Alzahrani, Abdulaziz K. Alaraifi, Lama H. Aldosari, Leen O. Hijazi, Fahad A. Alsaab
Clinical Manifestations Of Covid-19 Versus Other Upper Respiratory Tract Infections In Pediatric Patients, Manar M. Alzahrani, Abdulaziz K. Alaraifi, Lama H. Aldosari, Leen O. Hijazi, Fahad A. Alsaab
Saudi Medical Journal
Objectives: To explore the differences between COVID-19 and upper respiratory tract infections (URTI) in the pediatric population, emphasizing smell and taste disturbances. Methods: A case-control study included 468 patients, 234 with COVID-19 (cases) and 234 with URTI (controls) at a tertiary hospital, Riyadh, Saudi Arabia, from 2020-2021. Patients with bacterial URTI, lower tract respiratory infections, and speech or developmental delays were excluded. Statistical analysis was carried out using Statistical Analysis System, 9.2 version. A p -value of ≤0.05 was considered significant. Results: The male-to-female ratio was almost equal, with a mean age of 9.90±2.34. Multivariable logistic regression analysis showed that …
Clinical, Laboratory, And Chest Radiographic Characteristics Of Covid-19 Associated Severe Pediatric Pneumonia. A Retrospective Study, Ali A. Asseri, Saleh M. Al-Qahtani, Mohammed A. Algathradi, Ibrahim A. Alzaydani, Ahmed A. Al-Jarie, Ibrahim A. Al-Benhassan, Ibrahim A. Alhelali, Mona S. Alassiri, Ali A. Alrmelawi, Abdelwahid S. Ali
Clinical, Laboratory, And Chest Radiographic Characteristics Of Covid-19 Associated Severe Pediatric Pneumonia. A Retrospective Study, Ali A. Asseri, Saleh M. Al-Qahtani, Mohammed A. Algathradi, Ibrahim A. Alzaydani, Ahmed A. Al-Jarie, Ibrahim A. Al-Benhassan, Ibrahim A. Alhelali, Mona S. Alassiri, Ali A. Alrmelawi, Abdelwahid S. Ali
Saudi Medical Journal
Objectives: To evaluate the demographics, clinical presentation, laboratory data, chest radiographs, and outcomes of pediatric patients with critical coronavirus disease 2019 (COVID-19). Methods: This retrospective study included 34 children who were diagnosed with severe COVID-19 pneumonia between August 2020 and July 2021. Severe pneumonia was defined as fever, respiratory distress (tachypnea, chest retractions, and hypoxia [oxygen saturation <90% in room air]), and obvious infiltrations on chest radiography. Results: Ages of the patients ranged from newborns to 12 years old, with a median of 24 months (interquartile range: 12-72 months). Preschool-aged children were the most common age group (44%). Levels of inflammatory markers (C-reactive protein, ferritin, and procalcitonin) were elevated in most patients. A total of 13 patients developed severe acute respiratory distress syndrome (ARDS), while 4 developed multiorgan failure. Despite receiving supportive therapy, 2 (5.9%) patients died due to severe septic shock and multiorgan failure. One deceased patient was born prematurely at 30 weeks, while the other had chronic granulomatous disease. Conclusion: This study described a single-center cohort of pediatric patients with severe COVID-19 pneumonia. In this cohort, children with cardiopulmonary comorbidities and ARDS had a high mortality and long-term morbidity, as observed in other pediatric studies.
Meningitis Post-Cochlear Implant And Role Of Vaccination, Ghadah A. Alanazi, Aumniyat S. Alrashidi, Khalid S. Alqarni, Saeed A. Al Khozym, Saad Alenzi
Meningitis Post-Cochlear Implant And Role Of Vaccination, Ghadah A. Alanazi, Aumniyat S. Alrashidi, Khalid S. Alqarni, Saeed A. Al Khozym, Saad Alenzi
Saudi Medical Journal
Objectives: To investigate the incidence, risk factors, and management of meningitis in cochlear implant (CI)users. Methods: A systematic review was carried out using PubMed, Scopus, Web of Science, and Cochrane Central Register. Articles were considered relevant if reported any data on incidence, clinical presentations, the role of vaccination, management, and outcomes of meningitis after CI. Results: A total of 32 studies including 27358 patients were included, and meningitis was reported in only 202 cases. Meningitis occurred in the period ranging from 1 day to 72 months after CI. A total of 55 patients received the pneumococcal vaccine, while 20 patients …
Identification Of Human Immunodeficiency Virus -1 E Protein-Targeting Lead Compounds By Pharmacophore Based Screening, Mazen M. Almehmadi, Alaa A. Shafie, Mamdouh Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem A. Almalki, Ahad Amer Alsaiari, Amal Adnan Ashour
Identification Of Human Immunodeficiency Virus -1 E Protein-Targeting Lead Compounds By Pharmacophore Based Screening, Mazen M. Almehmadi, Alaa A. Shafie, Mamdouh Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem A. Almalki, Ahad Amer Alsaiari, Amal Adnan Ashour
Saudi Medical Journal
Objectives: To identify potential compounds by seeking the knowledge of molecular interactions between human immunodeficiency virus (HIV) glycoprotein (gp) 120 protein and anti-HIV drug (BMS-488043). Methods: This study is a computational structure-based drug design study, carried out at University of Taif, Saudi Arabia and African Genome Centre (AGC), Mohammed VI Polytechnic University, Benguerir, Morocco from January 2021 to March 2022. Initially, using the docked structure of gp120 with BMS-488043, a structure-based pharmacophore model was created. The generated model was utilized for virtual screening of the ZINC and ChemBridge database in order to identify hit compounds. To further assess the time-dependent …
Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Jawaher Alsughayyir, Yasser Almalki, Imtinan Alburayk, Mohrah Alalshaik, Ibrahim Aljoni, Mona Kandel, Mohammad A. Alfhili, Abdulmajeed A. Alabdullateef
Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Jawaher Alsughayyir, Yasser Almalki, Imtinan Alburayk, Mohrah Alalshaik, Ibrahim Aljoni, Mona Kandel, Mohammad A. Alfhili, Abdulmajeed A. Alabdullateef
Saudi Medical Journal
Objectives: To establish a nationwide epidemiological profile of transfusion-transmittable infection (TTI) markers among seemingly healthy blood donors to update policies required to ensure blood safety. Methods: A nationwide, cross-sectional study was designed to examine donor demographics and TTI prevalence during 2020 using data provided by the Ministry of Health, Saudi Arabia. Results: Collectively, a total of 375,218 whole blood units were donated, of which 32,758 (8.7%) were excluded due to TTI-related risk. The exclusion was based on a positive nucleic acid amplification test (NAT) or seroreactivity to hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), human …
Evaluate The Side Effect Associated With Covid-19 Vaccine On Adolescents In Riyadh, Saudi Arabia: A Cross-Section Study, Jehad A. Aldali, Fahad T. Alotaibi, Glowi A. Alasiri, Renad A. Almesned, Aroob M. Alromih, Afnan M. Almohandes, Shahad F. Alsenidi
Evaluate The Side Effect Associated With Covid-19 Vaccine On Adolescents In Riyadh, Saudi Arabia: A Cross-Section Study, Jehad A. Aldali, Fahad T. Alotaibi, Glowi A. Alasiri, Renad A. Almesned, Aroob M. Alromih, Afnan M. Almohandes, Shahad F. Alsenidi
Saudi Medical Journal
Objectives: To investigate the side effects of Pizer- BioNTech mRNA (BNT162b2) and Spikevax (mRNA- 1273) Coronavirus disease 2019 (COVID-19) vaccines on adolescents in Riyadh, Saudi Arabia. Methods: A cross-sectional study using an online questionnaire was carried out among COVID-19 vaccine adolescent recipients in Riyadh, Saudi Arabia. After receiving at least one dose of each vaccine, general and demographic data were collected, and vaccine-related side effects were evaluated. Results: The final sample consisted of 604 participants with a majority age group of 16-17 years old. Approximately 89.1% of the study participants were female. Most participants reported pain at the injection site …
Antibacterial And Anti-Biofilm Activity Of Plumbagin Against Multi-Drug Resistant Clinical Bacterial Isolates, Mohammad A. Alfhili, Irfan Ahmad, Yasser Alraey, Abdulaziz Alangari, Taha Alqahtani, Ayed A. Dera
Antibacterial And Anti-Biofilm Activity Of Plumbagin Against Multi-Drug Resistant Clinical Bacterial Isolates, Mohammad A. Alfhili, Irfan Ahmad, Yasser Alraey, Abdulaziz Alangari, Taha Alqahtani, Ayed A. Dera
Saudi Medical Journal
Objectives: To evaluate the antibacterial activity of plumbagin (PGN) against multidrug resistance (MDR) clinical isolates. Methods: This study was carried out at the Department of Clinical Lab Sciences, King Khalid University from October 6, 2021 to December 14, 2021. We investigated the antibacterial and anti-virulence activity of PGN against MDR Gram-negative ( Escherichia coli , Klebsiella pneumoniae , Salmonella Typhi , and Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus [S. aureus] , Staphylococcus saprophyticus [S. saprophyticus] , Streptococcus pyogenes , and Enterococcus faecalis ) clinical bacterial isolates. Agar well diffusion, microdilution assay, colony count method, biofilm formation, and time-kill …