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Comparison Of Different Integral Histogram Based Tracking Algorithms, Sriharsha Atluri Jan 2011

Comparison Of Different Integral Histogram Based Tracking Algorithms, Sriharsha Atluri

LSU Master's Theses

Object tracking is an important subject in computer vision with a wide range of applications – security and surveillance, motion-based recognition, driver assistance systems, and human-computer interaction. The proliferation of high-powered computers, the availability of high quality and inexpensive video cameras, and the increasing need for automated video analysis have generated a great deal of interest in object tracking algorithms. Tracking is usually performed in the context of high-level applications that require the location and/or shape of the object in every frame. Research is being conducted in the development of object tracking algorithms over decades and a number of approaches …

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Hydrodynamic Focusing Micropump Module With Pdms/Nickel-Particle Composite Diaphragms For Microfluidic Systems, Jeonghwan Kim Jan 2011

Hydrodynamic Focusing Micropump Module With Pdms/Nickel-Particle Composite Diaphragms For Microfluidic Systems, Jeonghwan Kim

LSU Master's Theses

In this research, a rapid prototype of multi-fluidic speed-modulating (MFSM) micropump which enables modulation of hydrodynamic focusing in micro-fluidic flow has been designed, fabricated, and characterized. The size of the entire module is 33 mm x 25 mm x 8 mm and comprises of three MFSM micropumps to achieve hydrodynamic focusing. These pumps are simultaneously operated by the same actuation source. Each micropump consists of Tesla-type valves in the bottom layer and PDMS/Ni-particle composite (PNPC) diaphragm in the middle layer. The deflection of the diaphragm is obtained by the external pneumatic force, and the permanent magnet controls the displacement resulting …

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Expression, Identification, And Bioactivity Of Recombinant Human Erythropoietin From Lmh/2a (Leghorn Male Hepatoma)Cell Line, Amanda Cecile Broussard Jan 2011

Expression, Identification, And Bioactivity Of Recombinant Human Erythropoietin From Lmh/2a (Leghorn Male Hepatoma)Cell Line, Amanda Cecile Broussard

LSU Master's Theses

Erythropoietin (EPO) is the main cytokine regulator for red blood-cell production in the human by binding to erythropoietin receptors to promote erythroid proliferation, survival and differentiation. Administration of recombinant human EPO (rhEPO) as a therapeutic has been shown to improve renal and non-renal anemia and this success has led to a high medical global demand. Chinese hamster ovary (CHO) cells, yeast, and bacteria have been used to produce rhEPO but nevertheless there is still a need for a low-cost and high quality expression system for rhEPO. LMH/2A cells, as an alternative model, were transfected with the codon optimized human EPO …

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In Vivo Evidence For The Iron-Binding Activity Of An Iron-Sulfur Cluster Assembly Protein Isca In Escherichia Coli, Wu Wang, Hao Huang, Guoqiang Tan, Fan Si, Min Liu, Aaron P. Landry, Jianxin Lu, Huangen Ding Dec 2010

In Vivo Evidence For The Iron-Binding Activity Of An Iron-Sulfur Cluster Assembly Protein Isca In Escherichia Coli, Wu Wang, Hao Huang, Guoqiang Tan, Fan Si, Min Liu, Aaron P. Landry, Jianxin Lu, Huangen Ding

Faculty Publications

IscA is a key member of the iron-sulfur cluster assembly machinery in prokaryotic and eukaryotic organisms; however, the physiological function of IscA still remains elusive. In the present paper we report the in vivo evidence demonstrating the iron-binding activity of IscA in Escherichia coli cells. Supplement of exogenous iron (1 μM) in M9 minimal medium is sufficient to maximize the iron binding in IscA expressed in E. coli cells under aerobic growth conditions. In contrast, IscU, an iron-sulfur cluster assembly scaffold protein, or CyaY, a bacterial frataxin homologue, fails to bind any iron in E. coli cells under the same …

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Source Identification In Two Criminal Cases Using Phylogenetic Analysis Of Hiv-1 Dna Sequences, Diane I. Scaduto, Jeremy M. Brown, Wade C. Haaland, Derrick J. Zwickl, David M. Hillis, Michael L. Metzker Dec 2010

Source Identification In Two Criminal Cases Using Phylogenetic Analysis Of Hiv-1 Dna Sequences, Diane I. Scaduto, Jeremy M. Brown, Wade C. Haaland, Derrick J. Zwickl, David M. Hillis, Michael L. Metzker

Faculty Publications

Phylogenetic analysis has been widely used to test the a priori hypothesis of epidemiological clustering in suspected transmission chains of HIV-1. Among studies showing strong support for relatedness between HIV samples obtained from infected individuals, evidence for the direction of transmission between epidemiologically related pairs has been lacking. During transmission of HIV, a genetic bottleneck occurs, resulting in the paraphyly of source viruses with respect to those of the recipient. This paraphyly establishes the direction of transmission, from which the source can then be inferred. Here, we present methods and results from two criminal cases, State of Washington v Anthony …

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Identifying The Quantum Correlations In Light-Harvesting Complexes, Kamil Brádler, Mark M. Wilde, Sai Vinjanampathy, Dmitry B. Uskov Dec 2010

Identifying The Quantum Correlations In Light-Harvesting Complexes, Kamil Brádler, Mark M. Wilde, Sai Vinjanampathy, Dmitry B. Uskov

Faculty Publications

One of the major efforts in the quantum biological program is to subject biological systems to standard tests or measures of quantumness. These tests and measures should elucidate whether nontrivial quantum effects may be present in biological systems. Two such measures of quantum correlations are the quantum discord and the relative entropy of entanglement. Here, we show that the relative entropy of entanglement admits a simple analytic form when dynamics and accessible degrees of freedom are restricted to a zero- and single-excitation subspace. We also simulate and calculate the amount of quantum discord that is present in the Fenna-Matthews-Olson protein …

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An Analytic Model Of Neutron Ambient Dose Equivalent And Equivalent Dose For Proton Radiotherapy, Rui Zhang, Angélica Pérez-Andújar, Jonas D. Fontenot, Phillip J. Taddei, Wayne D. Newhauser Dec 2010

An Analytic Model Of Neutron Ambient Dose Equivalent And Equivalent Dose For Proton Radiotherapy, Rui Zhang, Angélica Pérez-Andújar, Jonas D. Fontenot, Phillip J. Taddei, Wayne D. Newhauser

Faculty Publications

Stray neutrons generated in passively scattered proton therapy are of concern because they increase the risk that a patient will develop a second cancer. Several investigations characterized stray neutrons in proton therapy using experimental measurements and Monte Carlo simulations, but capabilities of analytical methods to predict neutron exposures are less well developed. The goal of this study was to develop a new analytical model to calculate neutron ambient dose equivalent in air and equivalent dose in phantom based on Monte Carlo modeling of a passively scattered proton therapy unit. The accuracy of the new analytical model is superior to a …

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Estimate Of The Uncertainties In The Relative Risk Of Secondary Malignant Neoplasms Following Proton Therapy And Intensity-Modulated Photon Therapy, Jonas D. Fontenot, Charles Bloch, David Followill, Uwe Titt, Wayne D. Newhauser Dec 2010

Estimate Of The Uncertainties In The Relative Risk Of Secondary Malignant Neoplasms Following Proton Therapy And Intensity-Modulated Photon Therapy, Jonas D. Fontenot, Charles Bloch, David Followill, Uwe Titt, Wayne D. Newhauser

Faculty Publications

Theoretical calculations have shown that proton therapy can reduce the incidence of radiation-induced secondary malignant neoplasms (SMN) compared with photon therapy for patients with prostate cancer. However, the uncertainties associated with calculations of SMN risk had not been assessed. The objective of this study was to quantify the uncertainties in projected risks of secondary cancer following contemporary proton and photon radiotherapies for prostate cancer. We performed a rigorous propagation of errors and several sensitivity tests to estimate the uncertainty in the ratio of relative risk (RRR) due to the largest contributors to the uncertainty: the radiation weighting factor for neutrons, …

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Assessment Of Targeting Accuracy Of A Low-Energy Stereotactic Radiosurgery Treatment For Age-Related Macular Degeneration, Phillip J. Taddei, Erik Chell, Steven Hansen, Michael Gertner, Wayne D. Newhauser Dec 2010

Assessment Of Targeting Accuracy Of A Low-Energy Stereotactic Radiosurgery Treatment For Age-Related Macular Degeneration, Phillip J. Taddei, Erik Chell, Steven Hansen, Michael Gertner, Wayne D. Newhauser

Faculty Publications

Age-related macular degeneration (AMD), a leading cause of blindness in the United States, is a neovascular disease that may be controlled with radiation therapy. Early patient outcomes of external beam radiotherapy, however, have been mixed. Recently, a novel multimodality treatment was developed, comprising external beam radiotherapy and concomitant treatment with a vascular endothelial growth factor inhibitor. The radiotherapy arm is performed by stereotactic radiosurgery, delivering a 16 Gy dose in the macula (clinical target volume, CTV) using three external low-energy x-ray fields while adequately sparing normal tissues. The purpose of our study was to test the sensitivity of the delivery …

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Adjustment Of The Lateral And Longitudinal Size Of Scanned Proton Beam Spots Using A Pre-Absorber To Optimize Penumbrae And Delivery Efficiency, Uwe Titt, Dragan Mirkovic, Gabriel O. Sawakuchi, Luis A. Perles, Wayne D. Newhauser, Phillip J. Taddei, Radhe Mohan Dec 2010

Adjustment Of The Lateral And Longitudinal Size Of Scanned Proton Beam Spots Using A Pre-Absorber To Optimize Penumbrae And Delivery Efficiency, Uwe Titt, Dragan Mirkovic, Gabriel O. Sawakuchi, Luis A. Perles, Wayne D. Newhauser, Phillip J. Taddei, Radhe Mohan

Faculty Publications

In scanned-beam proton therapy, the beam spot properties, such as the lateral and longitudinal size and the minimum achievable range, are influenced by beam optics, scattering media and drift spaces in the treatment unit. Currently available spot scanning systems offer fewoptions for adjusting these properties. We investigated a method for adjusting the lateral and longitudinal spot size that utilizes downstream plastic pre-absorbers located near a water phantom. The spot size adjustment was characterized usingMonte Carlo simulations of a modified commercial scanned-beam treatment head. Our results revealed that the pre-absorbers can be used to reduce the lateral full width at half …

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Methodology For Determining Doses To In-Field, Out-Of-Field And Partially In-Field Organs For Late Effects Studies In Photon Radiotherapy, Rebecca M. Howell, Sarah B. Scarboro, Phillip J. Taddei, Sunil Krishnan, Stephen F. Kry, Wayne D. Newhauser Dec 2010

Methodology For Determining Doses To In-Field, Out-Of-Field And Partially In-Field Organs For Late Effects Studies In Photon Radiotherapy, Rebecca M. Howell, Sarah B. Scarboro, Phillip J. Taddei, Sunil Krishnan, Stephen F. Kry, Wayne D. Newhauser

Faculty Publications

An important but little examined aspect of radiation dosimetry studies involving organs outside the treatment field is how to assess dose to organs that are partially within a treatment field; this question is particularly important for studies intended to measure total absorbed dose in order to predict the risk of radiogenic late effects, such as second cancers. The purpose of this investigation was therefore to establish a method to categorize organs as in-field, out-of-field or partially in-field that would be applicable to both conventional and modern radiotherapy techniques. In this study, we defined guidelines to categorize the organs based on …

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Risk Of Second Malignant Neoplasm Following Proton Versus Intensity-Modulated Photon Radiotherapies For Hepatocellular Carcinoma, Phillip J. Taddei, Rebecca M. Howell, Sunil Krishnan, Sarah B. Scarboro, Dragan Mirkovic, Wayne D. Newhauser Dec 2010

Risk Of Second Malignant Neoplasm Following Proton Versus Intensity-Modulated Photon Radiotherapies For Hepatocellular Carcinoma, Phillip J. Taddei, Rebecca M. Howell, Sunil Krishnan, Sarah B. Scarboro, Dragan Mirkovic, Wayne D. Newhauser

Faculty Publications

Hepatocellular carcinoma (HCC), the sixthmost common cancer in theworld, is a global health concern. Radiotherapy for HCC is uncommon, largely because of the likelihood of radiation-induced liver disease, an acute side effect that is often fatal. Proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT)may offer HCC patients a better option for treating the diseased liver tissue while largely sparing the surrounding tissues, especially the nontumor liver. However, even advanced radiotherapies carry a risk of late effects, including second malignant neoplasms (SMNs). It is unclear whether PBT or IMRT confers less risk of an SMN than the other. The purpose …

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Predicted Risks Of Second Malignant Neoplasm Incidence And Mortality Due To Secondary Neutrons In A Girl And Boy Receiving Proton Craniospinal Irradiation, Phillip J. Taddei, Anita Mahajan, Dragan Mirkovic, Rui Zhang, Annelise Giebeler, David Kornguth, Mark Harvey, Shiao Woo, Wayne D. Newhauser Dec 2010

Predicted Risks Of Second Malignant Neoplasm Incidence And Mortality Due To Secondary Neutrons In A Girl And Boy Receiving Proton Craniospinal Irradiation, Phillip J. Taddei, Anita Mahajan, Dragan Mirkovic, Rui Zhang, Annelise Giebeler, David Kornguth, Mark Harvey, Shiao Woo, Wayne D. Newhauser

Faculty Publications

The purpose of this study was to compare the predicted risks of second malignant neoplasm (SMN) incidence and mortality from secondary neutrons for a 9-year-old girl and a 10-year-old boy who received proton craniospinal irradiation (CSI). SMN incidence and mortality from neutrons were predicted from equivalent doses to radiosensitive organs for cranial, spinal and intracranial boost fields. Therapeutic proton absorbed dose and equivalent dose from neutrons were calculated using Monte Carlo simulations. Risks of SMN incidence and mortality in most organs and tissues were predicted by applying risks models from the National Research Council of the National Academies to the …

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Cross-Reactivity Virtual Profiling Of The Human Kinome By X-React Kin: A Chemical Systems Biology Approach, Michal Brylinski, Jeffrey Skolnick Dec 2010

Cross-Reactivity Virtual Profiling Of The Human Kinome By X-React Kin: A Chemical Systems Biology Approach, Michal Brylinski, Jeffrey Skolnick

Faculty Publications

Many drug candidates fail in clinical development due to their insufficient selectivity that may cause undesired side effects. Therefore, modern drug discovery is routinely supported by computational techniques, which can identify alternate molecular targets with a significant potential for cross-reactivity. In particular, the development of highly selective kinase inhibitors is complicated by the strong conservation of the ATP-binding site across the kinase family. In this paper, we describe X-ReactKIN, a new machine learning approach that extends the modeling and virtual screening of individual protein kinases to a system level in order to construct a cross-reactivity virtual profile for the human …

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Location, Location, Location: Compartmentalization Of Early Events In Leukotriene Biosynthesis (Journal Of Biological Chemistry (2010) 285, (25109-25114)), Marcia E. Newcomer, Nathaniel C. Gilbert Dec 2010

Location, Location, Location: Compartmentalization Of Early Events In Leukotriene Biosynthesis (Journal Of Biological Chemistry (2010) 285, (25109-25114)), Marcia E. Newcomer, Nathaniel C. Gilbert

Faculty Publications

No abstract provided.

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Mechanism Of Fiber Assembly: Treatment Of Aβ Peptide Aggregation With A Coarse-Grained United-Residue Force Field, Ana Rojas, Adam Liwo, Dana Browne, Harold A. Scheraga Dec 2010

Mechanism Of Fiber Assembly: Treatment Of Aβ Peptide Aggregation With A Coarse-Grained United-Residue Force Field, Ana Rojas, Adam Liwo, Dana Browne, Harold A. Scheraga

Faculty Publications

The growth mechanism of β-amyloid (Aβ) peptide fibrils was studied by a physics-based coarse-grained united-residue model and molecular dynamics (MD) simulations. To identify the mechanism of monomer addition to an Aβ1-40 fibril, we placed an unstructured monomer at a distance of 20 Å from a fibril template and allowed it to interact freely with the latter. The monomer was not biased towards fibril conformation by either the force field or the MD algorithm. With the use of a coarse-grained model with replica-exchange molecular dynamics, a longer timescale was accessible, making it possible to observe how the monomers probe different binding …

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Reproductive Status Regulates Expression Of Sex Steroid And Gnrh Receptors In The Olfactory Bulb, Karen P. Maruska, Russell D. Fernald Dec 2010

Reproductive Status Regulates Expression Of Sex Steroid And Gnrh Receptors In The Olfactory Bulb, Karen P. Maruska, Russell D. Fernald

Faculty Publications

Neuromodulators including gonadotropin-releasing hormone (GnRH) and sex steroids help integrate an animal's internal physiological state with incoming external cues, and can have profound effects on the processing of behaviorally relevant information, particularly from the olfactory system. While GnRH and steroid receptors are present in olfactory processing regions across vertebrates, little is known about whether their expression levels change with internal physiological state or external social cues. We used qRT-PCR to measure mRNA levels of two GnRH receptors (GnRH-R1, GnRH-R2), five sex steroid receptors (estrogen receptors: ERα, ERβa, ERβb; androgen receptors: ARα, ARβ), and aromatase in the olfactory bulb of the …

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A Membrane Protein/Signaling Protein Interaction Network For Arabidopsis Version Ampv2, Sylvie Lalonde, Antoinette Sero, Réjane Pratelli, Guillaume Pilot, Jin Chen, Maria I. Sardi, Saman A. Parsa, Do Young Kim, Biswa R. Acharya, Erica V. Stein, Heng Chen Hu, Florent Villiers, Kouji Takeda, Yingzhen Yang, Yong S. Han, Rainer Schwacke, William Chiang, Naohiro Kato, Dominique Loqué, Sarah M. Assmann, June M. Kwak, Julian I. Schroeder, Seung Y. Rhee, Wolf B. Frommer Dec 2010

A Membrane Protein/Signaling Protein Interaction Network For Arabidopsis Version Ampv2, Sylvie Lalonde, Antoinette Sero, Réjane Pratelli, Guillaume Pilot, Jin Chen, Maria I. Sardi, Saman A. Parsa, Do Young Kim, Biswa R. Acharya, Erica V. Stein, Heng Chen Hu, Florent Villiers, Kouji Takeda, Yingzhen Yang, Yong S. Han, Rainer Schwacke, William Chiang, Naohiro Kato, Dominique Loqué, Sarah M. Assmann, June M. Kwak, Julian I. Schroeder, Seung Y. Rhee, Wolf B. Frommer

Faculty Publications

Interactions between membrane proteins and the soluble fraction are essential for signal transduction and for regulating nutrient transport. To gain insights into the membrane-based interactome, 3,852 open reading frames (ORFs) out of a target list of 8,383 representing membrane and signaling proteins from Arabidopsis thaliana were cloned into a Gatewaycompatible vector. The mating-based split ubiquitin system was used to screen for potential protein-protein interactions (pPPIs) among 490 Arabidopsis ORFs. A binary robotic screen between 142 receptor-like kinases (RLKs), 72 transporters, 57 soluble protein kinases and phosphatases, 40 glycosyltransferases, 95 proteins of various functions, and 89 proteins with unknown function detected …

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Faculty Senate Newsletter, Holiday 2010, Louisiana State University And Agricultural & Mechanical College Dec 2010

Faculty Senate Newsletter, Holiday 2010, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from the President: Those who watch the operations of the administration from the outside are easily tempted to regard the basis of administrative action as the will to power or a taste for conspiracy or a lust for publicity. To be sure, all these passions flow through the administrative nervous system. The inside experience of the academic approximation of power, however, reveals a far different prime directive: fear. Readers of Shakespeare’s tragedies and history plays know the story all too well: a person with formidable talents who may or may not be suited to rule a domain and who …

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The Contribution Of Wildlife To Sustainable Natural Resource Utilization In Namibia: A Review, Diana L.Schalkwyk Van Schalkwyk, Kenneth W. Mcmillin, R. Corli Witthuhn, Louw C. Hoffman Dec 2010

The Contribution Of Wildlife To Sustainable Natural Resource Utilization In Namibia: A Review, Diana L.Schalkwyk Van Schalkwyk, Kenneth W. Mcmillin, R. Corli Witthuhn, Louw C. Hoffman

Faculty Publications

Namibia is the driest country in sub-Saharan Africa, but well known for its richness in species and sustainable natural resource utilization. The Namibian farming sector consists mainly of extensive farming systems. Cattle production contributes 54% of the livestock sector's production output, followed by sheep and goats (25%), hides and skins (9%), and other forms of agricultural production (12%). Namibia's freehold farmers have obtained ownership rights over land and livestock since the early 1900s; commercial rights over wildlife and plants were given to freehold farmers in 1967 and to communal farmers in 1996. Natural resource-based production systems then overtook agricultural production …

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Bb0250 Of Borrelia Burgdorferi Is A Conserved And Essential Inner Membrane Protein Required For Cell Division, Fang Ting Liang, Qilong Xu, Rakesh Sikdar, Ying Xiao, James S. Cox, William T. Doerrler Dec 2010

Bb0250 Of Borrelia Burgdorferi Is A Conserved And Essential Inner Membrane Protein Required For Cell Division, Fang Ting Liang, Qilong Xu, Rakesh Sikdar, Ying Xiao, James S. Cox, William T. Doerrler

Faculty Publications

The gene bb0250 of Borrelia burgdorferi is a homolog of the dedA family, encoding integral inner membrane proteins that are present in nearly all species of bacteria. To date, no precise function has been attributed to any dedA gene. Unlike many bacterial species, such as Escherichia coli, which has eight dedA genes, B. burgdorferi possesses only one, annotated bb0250, providing a unique opportunity to investigate the functions of the dedA family. Here, we show that bb0250 is able to restore normal growth and cell division to a temperature-sensitive E. coli mutant with simultaneous deletions of two dedA genes, yqjA and …

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Does Pyrogenicity Protect Burning Plants?, Paul R. Gagnon, Heather A. Passmore, William J. Platt, Jonathan A. Myers, C. E.Timothy Paine, Kyle E. Harms Dec 2010

Does Pyrogenicity Protect Burning Plants?, Paul R. Gagnon, Heather A. Passmore, William J. Platt, Jonathan A. Myers, C. E.Timothy Paine, Kyle E. Harms

Faculty Publications

Pyrogenic plants dominate many fire-prone ecosystems. Their prevalence suggests some advantage to their enhanced flammability, but researchers have had difficulty tying pyrogenicity to individual-level advantages. Based on our review, we propose that enhanced flammability in fire-prone ecosystems should protect the belowground organs and nearby propagules of certain individual plants during fires. We base this hypothesis on five points: (1) organs and propagules by which many fire-adapted plants survive fires are vulnerable to elevated soil temperatures during fires; (2) the degree to which burning plant fuels heat the soil depends mainly on residence times of fires and on fuel location relative …

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Functional Traits And The Growth-Mortality Trade-Off In Tropical Trees, S. Joseph Wright, Kaoru Kitajima, Nathan J.B. Kraft, Peter B. Reich, Ian J. Wright, Daniel E. Bunker, Richard Condit, James W. Dalling, Stuart J. Davies, Sandra Díaz, Bettina M.J. Engelbrecht, Kyle E. Harms, Stephen P. Hubbell, Christian O. Marks, Maria C. Ruiz-Jaen, Cristina M. Salvador, Amy E. Zanne Dec 2010

Functional Traits And The Growth-Mortality Trade-Off In Tropical Trees, S. Joseph Wright, Kaoru Kitajima, Nathan J.B. Kraft, Peter B. Reich, Ian J. Wright, Daniel E. Bunker, Richard Condit, James W. Dalling, Stuart J. Davies, Sandra Díaz, Bettina M.J. Engelbrecht, Kyle E. Harms, Stephen P. Hubbell, Christian O. Marks, Maria C. Ruiz-Jaen, Cristina M. Salvador, Amy E. Zanne

Faculty Publications

A trade-off between growth and mortality rates characterizes tree species in closed canopy forests. This trade-off is maintained by inherent differences among species and spatial variation in light availability caused by canopy-opening disturbances. We evaluated conditions under which the trade-off is expressed and relationships with four key functional traits for 103 tree species from Barro Colorado Island, Panama. The trade-off is strongest for saplings for growth rates of the fastest growing individuals and mortality rates of the slowest growing individuals (r2 = 0.69), intermediate for saplings for average growth rates and overall mortality rates (r 2=0.46), and much weaker for …

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Molecular Mechanisms Of Ligand-Mediated Attenuation Of Dna Binding By Marr Family Transcriptional Regulators, Inoka C. Perera, Anne Grove Dec 2010

Molecular Mechanisms Of Ligand-Mediated Attenuation Of Dna Binding By Marr Family Transcriptional Regulators, Inoka C. Perera, Anne Grove

Faculty Publications

Bacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group of transcriptional regulators that includes both repressors and activators, and the conventional mode of regulation entails a genetic locus in which the MarR homolog and a gene under its regulation are encoded divergently; binding of the MarR homolog to the intergenic region typically represses transcription of both genes, while binding of a specific ligand to the transcription factor results …

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Accurate Quantification Of Seasonal Rainfall And Associated Climate-Wildfire Relationships, Matthew G. Slocum, William J. Platt, Brian Beckage, Steve L. Orzell, Wayne Taylor Dec 2010

Accurate Quantification Of Seasonal Rainfall And Associated Climate-Wildfire Relationships, Matthew G. Slocum, William J. Platt, Brian Beckage, Steve L. Orzell, Wayne Taylor

Faculty Publications

Wildfires are often governed by rapid changes in seasonal rainfall. Therefore, measuring seasonal rainfall on a temporally finescale should facilitate the prediction of wildfire regimes. To explore this hypothesis, daily rainfall data over a 58-yr period (1950-2007) in south-central Florida were transformed into cumulative rainfall anomalies (CRAs). This transformation allowed precise estimation of onset dates and durations of the dry and wet seasons, as well as a number of other variables characterizing seasonal rainfall. These variables were compared with parameters that describe ENSO and a wildfire regimeinthe region (at the Avon Park Air Force Range). Onset dates and durations were …

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Colony Breeding System Influences Cuticular Bacterial Load Of Formosan Subterranean Termite (Isoptera: Rhinotermitidae) Workers, Claudia Husseneder, Dawn M. Simms, Gabriel K. Aluko, Jennifer Delatte Dec 2010

Colony Breeding System Influences Cuticular Bacterial Load Of Formosan Subterranean Termite (Isoptera: Rhinotermitidae) Workers, Claudia Husseneder, Dawn M. Simms, Gabriel K. Aluko, Jennifer Delatte

Faculty Publications

The goal of this study was to test whether the breeding system and/or the degree of inbreeding of field colonies of the Formosan subterranean termite, Coptotermes formosanus, Shiraki (Isoptera: Rhinotermitidae) influences bacterial load on the cuticle of foraging workers. We enumerated bacterial load on the cuticle of groups of workers foraging in 20 inground monitoring stations surrounding the French Market in New Orleans, LA, and identified bacteria species using 16S rRNA gene sequencing. We used microsatellite genotyping to assign the 20 worker groups to seven simple family colonies (headed by a single pair of reproductives) and four extended family colonies …

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2-(2-Chloropyridin-3-Yl)-N-Ethyl-4-Methyl-1,3-Oxazole-5-Carboxamide, Guiqiu Yang, Jiakuang Liang, Haibo Yu, Bin Li Dec 2010

2-(2-Chloropyridin-3-Yl)-N-Ethyl-4-Methyl-1,3-Oxazole-5-Carboxamide, Guiqiu Yang, Jiakuang Liang, Haibo Yu, Bin Li

Faculty Publications

In the title compound, C12H12ClN3O 2, the dihedral angle between the aromatic rings is 8.42 (10)°. In the crystal, molecules are linked by N - H⋯O hydrogen bonds, generating C(4) chains propagating in [001].

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Variation In The Checkpoint Kinase 2 Gene Is Associated With Type 2 Diabetes In Multiple Populations, Kari E. North, Nora Franceschini, Christy L. Avery, Lisa Baird, Mariaelisa Graff, Mark Leppert, Jay H. Chung, Jinghui Zhang, Craig Hanis, Eric Boerwinkle, Kelly A. Volcik, Megan L. Grove, Thomas H. Mosley, Charles Gu, Gerardo Heiss, James S. Pankow, David J. Couper, Christie M. Ballantyne, W. H. Linda Kao, Alan B. Weder, Richard S. Cooper, Georg B. Ehret, Ashley A. O'Connor, Aravinda Chakravarti, Steven C. Hunt Dec 2010

Variation In The Checkpoint Kinase 2 Gene Is Associated With Type 2 Diabetes In Multiple Populations, Kari E. North, Nora Franceschini, Christy L. Avery, Lisa Baird, Mariaelisa Graff, Mark Leppert, Jay H. Chung, Jinghui Zhang, Craig Hanis, Eric Boerwinkle, Kelly A. Volcik, Megan L. Grove, Thomas H. Mosley, Charles Gu, Gerardo Heiss, James S. Pankow, David J. Couper, Christie M. Ballantyne, W. H. Linda Kao, Alan B. Weder, Richard S. Cooper, Georg B. Ehret, Ashley A. O'Connor, Aravinda Chakravarti, Steven C. Hunt

Faculty Publications

Identification and characterization of the genetic variants underlying type 2 diabetes susceptibility can provide important understanding of the etiology and pathogenesis of type 2 diabetes. We previously identified strong evidence of linkage for type 2 diabetes on chromosome 22 among 3,383 Hypertension Genetic Epidemiology Network (HyperGEN) participants from 1,124 families. The checkpoint 2 (CHEK2) gene, an important mediator of cellular responses to DNA damage, is located 0.22 Mb from this linkage peak. In this study, we tested the hypothesis that the CHEK2 gene contains one or more polymorphic variants that are associated with type 2 diabetes in HyperGEN individuals. In …

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Interrogating Local Population Structure For Fine Mapping In Genome-Wide Association Studies, Huaizhen Qin, Nathan Morris, Sun J. Kang, Mingyao Li, Bamidele Tayo, Helen Lyon, Joel Hirschhorn, Richard S. Cooper, Xiaofeng Zhu Dec 2010

Interrogating Local Population Structure For Fine Mapping In Genome-Wide Association Studies, Huaizhen Qin, Nathan Morris, Sun J. Kang, Mingyao Li, Bamidele Tayo, Helen Lyon, Joel Hirschhorn, Richard S. Cooper, Xiaofeng Zhu

Faculty Publications

Motivation: Adjustment for population structure is necessary to avoid bias in genetic association studies of susceptibility variants for complex diseases. Population structure may differ from one genomic region to another due to the variability of individual ancestry associated with migration, random genetic drift or natural selection. Current association methods for correcting population stratification usually involve adjustment of global ancestry between study subjects.Results: We suggest interrogating local population structure for fine mapping to more accurately locate true casual genes by better adjusting the confounding effect due to local ancestry. By extensive simulations on genome-wide datasets, we show that adjusting global ancestry …

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The Deda Protein Family In Selected Bacterial Species, James Cox Dec 2010

The Deda Protein Family In Selected Bacterial Species, James Cox

Honors Capstones

No abstract provided.

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