Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (1691)
- Physical Sciences and Mathematics (1260)
- Social and Behavioral Sciences (790)
- Engineering (704)
- Chemistry (415)
-
- Arts and Humanities (369)
- Environmental Sciences (330)
- Biology (311)
- Oceanography and Atmospheric Sciences and Meteorology (264)
- Medicine and Health Sciences (262)
- Agriculture (260)
- Ecology and Evolutionary Biology (236)
- Psychology (226)
- Plant Sciences (212)
- Animal Sciences (192)
- Education (182)
- Civil and Environmental Engineering (175)
- Entomology (170)
- Genetics and Genomics (153)
- Veterinary Medicine (138)
- Chemical Engineering (131)
- Mechanical Engineering (117)
- Sociology (112)
- Population Biology (109)
- Earth Sciences (105)
- Biochemistry, Biophysics, and Structural Biology (95)
- Communication (87)
- Anthropology (83)
- Electrical and Computer Engineering (83)
- Oceanography (79)
- Keyword
-
- Biology (855)
- Agriculture (364)
- Chemistry (222)
- Education (182)
- Microbiology (135)
-
- Psychology (131)
- Zoology (131)
- Entomology (110)
- Botany (107)
- Louisiana (107)
- Engineering (106)
- Ecology (97)
- General (92)
- Obesity (87)
- Climate change (84)
- Genetics (79)
- Animal physiology (78)
- Biochemistry (69)
- Clinical (64)
- Agronomy (63)
- Molecular (61)
- Evolution (57)
- Phylogeny (57)
- Gulf of Mexico (55)
- Food science and technology (54)
- Inflammation (54)
- Literature (54)
- Rice (54)
- Biological control (52)
- Ecology; Biology (49)
- Publication Year
- Publication
-
- Faculty Publications (5097)
- LSU Doctoral Dissertations (2400)
- LSU Historical Dissertations and Theses (2274)
- LSU Master's Theses (2121)
- Honors Capstones (510)
-
- Division of Basic Science Faculty Publications (220)
- Clinical Research Faculty Publications (180)
- Louisiana Agriculture (129)
- Occasional Papers of the Museum of Natural Science, Louisiana State University (94)
- LSU Agricultural Experiment Station Reports (89)
- Population and Public Health Science Faculty Publications (83)
- LSU General Catalog (47)
- 1650-1850: Ideas, Aesthetics, and Inquiries in the Early Modern Era (41)
- Gumbo Yearbook (31)
- Distinguished Undergraduate Researcher Program (26)
- Civil War Book Review (25)
- LSU Faculty Senate Publications (25)
- Communications on Stochastic Analysis (20)
- Taboo: The Journal of Culture and Education (17)
- LSU AgCenter Bulletins (16)
- College of Science Patents (15)
- Research Matters & RNR Newsletters (14)
- 2026 LSU Symposium on Control, Learning, and Intelligent Systems (12)
- Research Magazine (12)
- Components (10)
- Publications (10)
- Student Senate Enrolled Legislation (9)
- College of Engineering Patents (8)
- Horticulture Hints (7)
- Journal of Stochastic Analysis (7)
- Publication Type
- File Type
Articles 451 - 480 of 13611
Full-Text Articles in Entire DC Network
Deep Learning-Based Geomorphic Feature Identification In Dredge Pit Marine Environment, Wenqiang Zhang, Xiaobing Chen, Xiangwei Zhou, Jianhua Chen, Jianguo Yuan, Taibiao Zhao, Kehui Xu
Deep Learning-Based Geomorphic Feature Identification In Dredge Pit Marine Environment, Wenqiang Zhang, Xiaobing Chen, Xiangwei Zhou, Jianhua Chen, Jianguo Yuan, Taibiao Zhao, Kehui Xu
Faculty Publications
Deep learning methods paired with sidescan sonar (SSS) are commonly used in underwater search-and-rescue operations for drowning victims, wrecks, and airplanes. However, these techniques are primarily used to detect mine-like objects and are rarely applied to identifying features in dynamic dredge pit environments. In this study, we present a Sandy Point dredge pit (SPDP) dataset, in which high-resolution SSS data were collected from the west flank of the Mississippi bird-foot delta on the Louisiana inner shelf. This dataset contains a total of 385 SSS images. We then introduce a new Effective Geomorphology Classification model (EGC). Through ablation studies, we analyze …
The Effect Of Season On Neuroendocrine Interactions In The Mare, Victoria N. Bailey
The Effect Of Season On Neuroendocrine Interactions In The Mare, Victoria N. Bailey
LSU Doctoral Dissertations
Reproductive seasonality in the mare involves various neuroendocrine modulations, and a series of experiments were conducted to investigate the anatomical and physiological roles of some of these seasonal modulators. The first experiment incorporated kisspeptin-10 (Kp10) into a treatment with estradiol benzoate (EB) and sulpiride, aiming to induce early cyclicity in seasonally anovulatory mares. Incorporation of Kp10 resulted in more mares ovulating earlier compared to mares receiving EB-sulpiride. Although plasma prolactin increased in both groups, concentrations were notably higher in Kp10-treated mares. Therefore, the subsequent experiment explored the anatomical interaction of kisspeptin and prolactin, aiming to determine whether kisspeptin may regulate …
Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu
Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu
Division of Basic Science Faculty Publications
Declined memory is a hallmark of Alzheimer’s disease (AD). Experiments in rodents and human postmortem studies suggest that serotonin (5-hydroxytryptamine, 5-HT) plays a role in memory, but the underlying mechanisms are unknown. Here, we investigate the role of 5-HT 2C receptor (5-HT2CR) in regulating memory. Transgenic mice expressing a humanized HTR2C mutation exhibit impaired plasticity of hippocampal ventral CA1 (vCA1) neurons and reduced memory. Further, 5-HT neurons project to and synapse onto vCA1 neurons. Disruption of 5-HT synthesis in vCA1-projecting neurons or deletion of 5-HT2CRs in the vCA1 impairs neural plasticity and memory. We show that a selective 5-HT2CR agonist, …
The Ring-Closing Reaction Of Cyclopentadiene Probed With Ultrafast X-Ray Scattering, Lisa Huang, Lauren Bertram, Lingyu Ma, Nathan Goff, Stuart W. Crane, Asami Odate, Thomas Northey, Andrés Moreno Carrascosa, Mats Simmermacher, Sri Bhavya Muvva, Joseph D. Geiser, Matthew J. Lueckheide, Zane Phelps, Mengning Liang, Xinxin Cheng, Ruaridh Forbes, Joseph S. Robinson, Matthew J. Hayes, Felix Allum, Alice E. Green, Kenneth Lopata, Artem Rudenko, Thomas J.A. Wolf, Martin Centurion, Daniel Rolles, Michael P. Minitti, Adam Kirrander, Peter M. Weber
The Ring-Closing Reaction Of Cyclopentadiene Probed With Ultrafast X-Ray Scattering, Lisa Huang, Lauren Bertram, Lingyu Ma, Nathan Goff, Stuart W. Crane, Asami Odate, Thomas Northey, Andrés Moreno Carrascosa, Mats Simmermacher, Sri Bhavya Muvva, Joseph D. Geiser, Matthew J. Lueckheide, Zane Phelps, Mengning Liang, Xinxin Cheng, Ruaridh Forbes, Joseph S. Robinson, Matthew J. Hayes, Felix Allum, Alice E. Green, Kenneth Lopata, Artem Rudenko, Thomas J.A. Wolf, Martin Centurion, Daniel Rolles, Michael P. Minitti, Adam Kirrander, Peter M. Weber
Faculty Publications
The dynamics of cyclopentadiene (CP) following optical excitation at 243 nm was investigated by time-resolved pump-probe X-ray scattering using 16.2 keV X-rays at the Linac Coherent Light Source (LCLS). We present the first ultrafast structural evidence that the reaction leads directly to the formation of bicyclo[2.1.0]pentene (BP), a strained molecule with three- and four-membered rings. The bicyclic compound decays via a thermal backreaction to the vibrationally hot CP with a time constant of 21 ± 3 ps. A minor channel leads to ring-opened structures on a subpicosecond time scale.
Emotional Reactivity And Recognition Deficits In Individuals With Callous-Unemotional (Cu) Traits: A Multilevel Meta-Analysis, Emily C. Kemp
Emotional Reactivity And Recognition Deficits In Individuals With Callous-Unemotional (Cu) Traits: A Multilevel Meta-Analysis, Emily C. Kemp
LSU Doctoral Dissertations
Youth and adults with antisocial behavior present a significant mental health concern. Elevated callous-unemotional (CU) traits, characterized by deficient empathy and remorse, distinguish clinically important subgroups of antisocial individuals who present with more severe behavior and distinct cognitive-affective characteristics that may help to explain the underlying causes of their antisocial behavior and inform more effective treatments. Specifically, two mechanisms theorized to underlie the development of elevated CU traits by way of atypical empathy development are deficient reactivity to and recognition of others’ emotions. Though a substantive literature base reports associations between CU traits and emotional processing deficits, significant inconsistencies remain. …
Factors Associated With Functioning In Older Black Adults, Katrail D. Davis
Factors Associated With Functioning In Older Black Adults, Katrail D. Davis
LSU Master's Theses
Activities of daily living can be simple tasks such as bathing, showering, toileting or as complex as managing finances, driving, and preparing meals. Independence in everyday functioning has been associated with successful aging and declines in functioning may be indicative of pathological cognitive decline. Social determinants of health, like economic status and access to health care, also play a role in everyday functioning. Understanding these factors are of particular importance for older Black adults who have had long-standing disparate access to care, education, and treatments. The current study aimed to evaluate social determinants of health, more specifically social engagement, as …
No Evidence For Metabolic Adaptation During Exercise-Related Energy Compensation, E. W. Flanagan, G. Sanchez-Delgado, C. K. Martin, E. Ravussin, H. Pontzer, L. M. Redman
No Evidence For Metabolic Adaptation During Exercise-Related Energy Compensation, E. W. Flanagan, G. Sanchez-Delgado, C. K. Martin, E. Ravussin, H. Pontzer, L. M. Redman
Clinical Research Faculty Publications
The constrained energy model posits that the increased total daily energy expenditure (TDEE) in response to exercise is often less than the energy cost of the exercise prescribed. The mechanisms behind this phenomenon, coined “exercise-related energy compensation” (ExEC), are poorly understood, and it is unknown if ExEC is coupled with metabolic adaptation. Using a randomized controlled 24-week exercise intervention, individuals who demonstrated ExEC were identified. Changes to all components of TDEE and metabolic adaptation were assessed using doubly labeled water over 14 days and room calorimetry over 24-h 48% of individuals exhibited ExEC (−308 ± 158 kcals/day). There were no …
The Relationship Between Communicative And Social Deficits And Challenging Behavior In Angelman Syndrome, Cassie Chanel Feck
The Relationship Between Communicative And Social Deficits And Challenging Behavior In Angelman Syndrome, Cassie Chanel Feck
LSU Doctoral Dissertations
Angelman Syndrome (AS) is a low-incidence neurodevelopmental disorder characterized by deficits in speech, motor, and social development as well as related differences in challenging behavior, seizures, and sleep issues. AS has a known genetic etiology and research conducted with this population has overwhelmingly focused on exploring the genetic and biological underpinnings of the disorder (e.g., applied gene therapies). At present, far less research on supporting the social, communicative, and behavioral needs of this population and how these specific deficits contribute to the individual’s overall functioning. The goals of this study were to characterize the use of Augmentative and Alternative Communication …
A Microfluidic Approach To Study Variations In Chlamydomonas Reinhardtii Alkaline Phosphatase Activity In Response To Phosphate Availability, Alireza Rahnama, Manibarathi Vaithiyanathan, Luis Briceno-Mena, Travis M. Dugas, Kelly L. Yates, Jose A. Romagnoli, Adam T. Melvin
A Microfluidic Approach To Study Variations In Chlamydomonas Reinhardtii Alkaline Phosphatase Activity In Response To Phosphate Availability, Alireza Rahnama, Manibarathi Vaithiyanathan, Luis Briceno-Mena, Travis M. Dugas, Kelly L. Yates, Jose A. Romagnoli, Adam T. Melvin
Faculty Publications
Algal growth depends strongly on phosphorus (P) as a key nutrient, underscoring the significance of monitoring P levels. Algal species display a sensitive response to fluctuations in P availability, notably through the expression of alkaline phosphatase (AP) when challenged with P-depletion. As such, alkaline phosphatase activity (APA) serves as a valuable metric for P availability, offering insights into how algae utilize and fix available P resources. However, current APA quantification methods lack single cell resolution, while also being time- and reagent consuming. Microfluidics offers a promising cost-effective solution to these limitations, providing a platform for precise single-cell analysis. In this …
The Mitochondrial Multi-Omic Response To Exercise Training Across Rat Tissues, David Amar, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A. Gaul, Steven G. Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M. Fernández, Stephen B. Montgomery, Andrea L. Hevener, Euan A. Ashley, Martin J. Walsh, Lauren M. Sparks, Charles F. Burant, R. Scott Rector, John Thyfault, Matthew T. Wheeler, Bret H. Goodpaster, Paul M. Coen, Simon Schenk, Sue C. Bodine, Malene E. Lindholm, Joshua N. Adkins, Jose Juan Almagro Armenteros, Mary Anne S. Amper, Dam Bae, Marcas Bamman
The Mitochondrial Multi-Omic Response To Exercise Training Across Rat Tissues, David Amar, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A. Gaul, Steven G. Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M. Fernández, Stephen B. Montgomery, Andrea L. Hevener, Euan A. Ashley, Martin J. Walsh, Lauren M. Sparks, Charles F. Burant, R. Scott Rector, John Thyfault, Matthew T. Wheeler, Bret H. Goodpaster, Paul M. Coen, Simon Schenk, Sue C. Bodine, Malene E. Lindholm, Joshua N. Adkins, Jose Juan Almagro Armenteros, Mary Anne S. Amper, Dam Bae, Marcas Bamman
Clinical Research Faculty Publications
Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative …
Age, Growth, And Mortality Of Blackfin Tuna In The Gulf Of Mexico, E. M. Gutierrez, E. T. Lang, M. S. Lovell, J. Lang, B. J. Falterman, S. R. Midway, M. A. Dance
Age, Growth, And Mortality Of Blackfin Tuna In The Gulf Of Mexico, E. M. Gutierrez, E. T. Lang, M. S. Lovell, J. Lang, B. J. Falterman, S. R. Midway, M. A. Dance
Faculty Publications
Objective: An otolith-based aging approach was used to evaluate age and growth relationships, sexual dimorphism in growth, and derive mortality estimates for Blackfin Tuna Thunnus atlanticus in the Gulf of Mexico (GOM). Methods: Blackfin Tuna (n = 395) were sampled from recreational fisheries and aged from 0 to 13 years, representing an increase over previous estimates of longevity for the species. Result: Rapid growth was exhibited during the first two years of life, and the Richards growth function provided a better fit (L∞ = 907 mm, k = 0.112 /year, a = 1.05, b = 0.25) to the data compared …
Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan
Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan
Faculty Publications
Clanis bilineata Walker (Lepidoptera: Sphingidae), a burgeoning edible insect, is experiencing rising demand in China and other regions. Despite this interest, larval production is currently constrained by the limitations of artificial production technologies, particularly the selection of optimal host plants. This study rigorously evaluated the performance of C. bilineatha larvae on four main host plants: round-leaf soybean, pointed-leaf soybean, black locust, and kudzu. Preference tests demonstrated that the larvae were most attracted to black locust (34.76 ± 4.65%), with subsequent preferences for kudzu (25.00 ± 6.12%), round-leaf soybean (23.17 ± 2.79%), and pointed-leaf soybean (14.02 ± 4.74%). No significant preference …
Adaptive Phase I–Ii Clinical Trial Designs Identifying Optimal Biological Doses For Targeted Agents And Immunotherapies, Yong Zang, Beibei Guo, Yingjie Qiu, Hao Liu, Mateusz Opyrchal, Xiongbin Lu
Adaptive Phase I–Ii Clinical Trial Designs Identifying Optimal Biological Doses For Targeted Agents And Immunotherapies, Yong Zang, Beibei Guo, Yingjie Qiu, Hao Liu, Mateusz Opyrchal, Xiongbin Lu
Faculty Publications
Targeted agents and immunotherapies have revolutionized cancer treatment, offering promising options for various cancer types. Unlike traditional therapies the principle of “more is better” is not always applicable to these new therapies due to their unique biomedical mechanisms. As a result, various phase I–II clinical trial designs have been proposed to identify the optimal biological dose that maximizes the therapeutic effect of targeted therapies and immunotherapies by jointly monitoring both efficacy and toxicity outcomes. This review article examines several innovative phase I–II clinical trial designs that utilize accumulated efficacy and toxicity outcomes to adaptively determine doses for subsequent patients and …
Evaluation Of Esterases Hydrolyzing Α-Naphthyl Acetate As Markers For Malathion Resistance In Culex Quinquefasciatus, Vivek Pokhrel, James A. Ottea
Evaluation Of Esterases Hydrolyzing Α-Naphthyl Acetate As Markers For Malathion Resistance In Culex Quinquefasciatus, Vivek Pokhrel, James A. Ottea
Faculty Publications
Early detection of insecticide resistance is essential to develop resistance countermeasures and depends on accurate and rapid biological and biochemical tests to monitor resistance and detect associated mechanisms. Many such studies have measured activities of esterases, enzymes associated with resistance to ester- containing insecticides, using the model substrate, α-naphthyl acetate (α-NA). However, in the field, pests are exposed to ester-containing insecticides such as malathion, that are structurally distinct from α-NA. In the current study, malathion resistance in C. quinquefasciatus (3.2- to 10.4-fold) was highly associated with esterase activity measured with either α-NA (R2 = 0.92) or malathion (R2 = 0.90). …
Recycling Functional Fillers From Waste Tires For Tailored Polystyrene Composites: Mechanical, Fire Retarding, Electromagnetic Field Shielding, And Acoustic Insulation Properties—A Short Review, Jinlong Zhang, Hang Liu, Shyam S. Sablani, Qinglin Wu
Recycling Functional Fillers From Waste Tires For Tailored Polystyrene Composites: Mechanical, Fire Retarding, Electromagnetic Field Shielding, And Acoustic Insulation Properties—A Short Review, Jinlong Zhang, Hang Liu, Shyam S. Sablani, Qinglin Wu
Faculty Publications
Polymer waste is currently a big and challenging issue throughout the world. Waste tires represent an important source of polymer waste. Therefore, it is highly desirable to recycle functional fillers from waste tires to develop composite materials for advanced applications. The primary theme of this review involves an overview of developing polystyrene (PS) composites using materials from recycled tires as fillers; waste tire recycling in terms of ground tire rubbers, carbon black, and textile fibers; surface treatments of the fillers to optimize various composite properties; and the mechanical, fire retarding, acoustic, and electromagnetic field (EMI) shielding performances of PS composite …
Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber
Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber
Division of Basic Science Faculty Publications
The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress …
Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas
Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas
Division of Basic Science Faculty Publications
Particulate matter (PM) containing environmentally persistent free radicals (EPFR) is formed by the incomplete combustion of organic wastes, resulting in the chemisorption of pollutants to the surface of PM containing redox-Active transition metals. In prior studies in mice, EPFR inhalation impaired endothelium-dependent vasodilation. These findings were associated with aryl hydrocarbon receptor (AhR) activation in the alveolar type-II (AT-II) cells that form the air-blood interface in the lung. We thus hypothesized that AhR activation in AT-II cells promotes the systemic release of mediators that promote endothelium dysfunction peripheral to the lung. To test our hypothesis, we knocked down AhR in AT-II …
Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu
Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu
Division of Basic Science Faculty Publications
No abstract provided.
Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang
Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang
Division of Basic Science Faculty Publications
Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with estrogen (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving glucose tolerance in mice. Mechanistically, we found that nicotinamide phosphoribosyl transferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting NAMPT …
Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier
Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier
Division of Basic Science Faculty Publications
Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice. Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group. Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had …
Effect Of Long-Term Caloric Restriction On Telomere Length In Healthy Adults: Calerie™ 2 Trial Analysis, Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. Macisaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev
Effect Of Long-Term Caloric Restriction On Telomere Length In Healthy Adults: Calerie™ 2 Trial Analysis, Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. Macisaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev
Clinical Research Faculty Publications
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior analyses of CALERIE™ participants' blood chemistries, immunology, and epigenetic data suggest the 2-year CR intervention slowed biological aging. Here, we extend these analyses to test effects of CR on telomere length (TL) attrition. TL was quantified in blood samples collected at baseline, 12-, …
Increasing Mowing Height And Nitrogen Fertility Does Not Enhance Unirrigated Centipedegrass Summer Drought Stress, Mike Adams, Jeffrey Beasley, Jeff Kuehny, Dylan Watson
Increasing Mowing Height And Nitrogen Fertility Does Not Enhance Unirrigated Centipedegrass Summer Drought Stress, Mike Adams, Jeffrey Beasley, Jeff Kuehny, Dylan Watson
Faculty Publications
Proper N fertilization and higher mowing heights are recommended to enhance rooting for greater turfgrass summer drought stress. To examine the effects of these primary cultural practices on centipedegrass [Eremochloa ophiuroides (Munro) Hack.] drought response in the mid-Southern United States, a study was conducted to evaluate four mowing heights (1, 2, 3 and 4 inches) and N fertilization versus no fertilization. During the study, roots were periodically harvested at upper (0–3 inches) and lower (3–6 inches) soil depths, and roots were analyzed for architecture which included root length (RL) and surface area (SA), and root weight (RW). In July, plant-soil …
Phytochemical Profiling And Bioactive Potential Of Grape Seed Extract In Enhancing Salinity Tolerance Of Vicia Faba, Doaa E. Elsherif, Fatmah A. Safhi, Prasanta K. Subudhi, Abdelghany S. Shaban, Mai A. El-Esawy, Asmaa M. Khalifa
Phytochemical Profiling And Bioactive Potential Of Grape Seed Extract In Enhancing Salinity Tolerance Of Vicia Faba, Doaa E. Elsherif, Fatmah A. Safhi, Prasanta K. Subudhi, Abdelghany S. Shaban, Mai A. El-Esawy, Asmaa M. Khalifa
Faculty Publications
Salinity stress poses a significant threat to crop productivity worldwide, necessitating effective mitigation strategies. This study investigated the phytochemical composition and potential of grape seed extract (GSE) to mitigate salinity stress effects on faba bean plants. GC–MS analysis revealed several bioactive components in GSE, predominantly fatty acids. GSE was rich in essential nutrients and possessed a high antioxidant capacity. After 14 days of germination, GSE was applied as a foliar spray at different concentrations (0, 2, 4, 6, and 8 g/L) to mitigate the negative effects of salt stress (150 mM NaCl) on faba bean plants. Foliar application of 2–8 …
Nutritive Value And Forage Accumulation Of A Black Oat Germplasm In The Northeastern United States, David M. Jaramillo, Kathy Soder, Ann Blount, Jose C.B. Dubeux, Stephen Harrison
Nutritive Value And Forage Accumulation Of A Black Oat Germplasm In The Northeastern United States, David M. Jaramillo, Kathy Soder, Ann Blount, Jose C.B. Dubeux, Stephen Harrison
Faculty Publications
Black oat (Avena strigosa Schreb.) might be an attractive forage species in the northeastern United States, since it is generally more heat tolerant and disease resistant than other cool-season grasses. Black oat is currently recommended for fall and winter production in USDA Plant Hardiness ones 8b–10a, which is beyond the northeastern United States (Zones 2a–6a). The objective was to evaluate 10 black oat breeding lines (referred to as “UF1” through “UF10”) for forage accumulation, crude protein (CP), neutral detergent fiber (aNDF), acid detergent fiber (ADF), and in vitro digestible organic matter (IVDOM) concentrations. The experiment was carried out in April–July …
Assessing The Long-Term Effects Of Conservation Agriculture On Cotton Production In Northeast Louisiana Using The Denitrification–Decomposition Model, Janntul Ferdush, Changyoon Jeong, Hwangju Jeon, Jim Wang, Kyoung Ro, Xi Zhang, Meesook Lee
Assessing The Long-Term Effects Of Conservation Agriculture On Cotton Production In Northeast Louisiana Using The Denitrification–Decomposition Model, Janntul Ferdush, Changyoon Jeong, Hwangju Jeon, Jim Wang, Kyoung Ro, Xi Zhang, Meesook Lee
Faculty Publications
Conservation agriculture (CA) aims to sustain agricultural production, soil, and environmental health in agroecosystems and has been promoted throughout the United States. The adoption of CA in cotton (Gossypium hirsutum) systems provides both agronomic and environmental benefits. Yet, there is limited information on the long-term effects of CA practices on crop yield and adaptation strategies. An integrated CA system, that is, cover crops with no-tillage (NT) instead of conventional agriculture, was implemented in the long-term field experiments and assessed with an integrated biogeochemical model. Using the denitrification–decomposition model, this study estimated the effects of four different cover crops, for example, …
Targeting Cancers With Ohsv-Based Oncolytic Viral Immunotherapy, Rakin Tammam Nasar, Ifeanyi Kingsley Uche, Konstantin G. Kousoulas
Targeting Cancers With Ohsv-Based Oncolytic Viral Immunotherapy, Rakin Tammam Nasar, Ifeanyi Kingsley Uche, Konstantin G. Kousoulas
Faculty Publications
The recent success of cancer immunotherapies, such as immune checkpoint inhibitor (ICIs), monoclonal antibodies (mAbs), cancer vaccines, and adoptive cellular therapies (ACTs), has revolutionized traditional cancer treatment. However, these immunotherapeutic modalities have variable efficacies, and many of them exhibit adverse effects. Oncolytic viral Immunotherapy (OViT), whereby viruses are used to directly or indirectly induce anti-cancer immune responses, is emerging as a novel immunotherapy for treating patients with different types of cancer. The herpes simplex virus type-1 (HSV-1) possesses many characteristics that inform its use as an effective OViT agents and remains a leading candidate. Its recent clinical success resulted in …
Thermochromic Yarns’ Application In Fever Detection For Young Children, Sibei Xia, Chuanlan Liu, Yanbo Zhang, Bruce Cameron
Thermochromic Yarns’ Application In Fever Detection For Young Children, Sibei Xia, Chuanlan Liu, Yanbo Zhang, Bruce Cameron
Faculty Publications
The existing literature emphasizes the significance of and needs for developing body temperature monitoring devices that can consistently and discreetly assess the temperatures of young children. Such products could offer a method to check children’s body temperature and alleviate parents’ concerns over fever. However, research gaps and challenges exist in preserving material flexibility, conducting tests in a controlled setting that mimics body temperature, and investigating consumer perceptions of this type of functional textile product. Therefore, this research aimed to investigate functional textiles using thermochromic yarns for young children’s body temperature detection, particularly focusing on testing prototypes in a controlled environment …
Impact Of Low-Load Resistance Exercise With And Without Blood Flow Restriction On Muscle Strength, Endurance, And Oxidative Capacity: A Pilot Study, Brett H. Davis, James E. Stampley, Joshua Granger, Matthew C. Scott, Timothy D. Allerton, Neil M. Johannsen, Guillaume Spielmann, Brian A. Irving
Impact Of Low-Load Resistance Exercise With And Without Blood Flow Restriction On Muscle Strength, Endurance, And Oxidative Capacity: A Pilot Study, Brett H. Davis, James E. Stampley, Joshua Granger, Matthew C. Scott, Timothy D. Allerton, Neil M. Johannsen, Guillaume Spielmann, Brian A. Irving
Clinical Research Faculty Publications
Low-load resistance exercise (LLRE) to failure can increase muscle mass, strength, endurance, and mitochondrial oxidative capacity (OXPHOS). However, the impact of adding blood flow restriction to low-load resistance exercise (LLBFR) when matched for volume on these outcomes is incompletely understood. This pilot study examined the impact of 6 weeks of single-legged LLBFR and volume-matched LLRE on thigh bone-free lean mass, strength, endurance, and mitochondrial OXPHOS. Twenty (12 males and 8 females) untrained young adults (mean ± SD; 21 ± 2 years, 168 ± 11 cm, 68 ± 12 kg) completed 6 weeks of either single-legged LLBFR or volume-matched LLRE. Participants …
Modeling And Forecasting Cyanobacterial Harmful Algal Blooms (Cyanohabs) In Lake Pontchartrain, Shekhar Mahat
Modeling And Forecasting Cyanobacterial Harmful Algal Blooms (Cyanohabs) In Lake Pontchartrain, Shekhar Mahat
LSU Master's Theses
Harmful algal blooms (HABs) frequently occur in coastal waters worldwide, adversely affecting economies, human health, aquatic ecosystems, and recreational activities. Lake Pontchartrain, an oligohaline estuary, experienced frequent HABs from 2018 to 2023. While NOAA’s NCCOS and USEPA’s CyAN currently monitor cyanobacteria harmful algal blooms (CyanoHABs) in coastal, freshwater, and riverine systems, there is a notable lack of systems monitoring phycocyanin concentrations in the lake. This thesis utilizes satellite remote sensing environmental stressors to model and predict CyanoHABs in Lake Pontchartrain using machine learning techniques. A key focus of this study is assessing the forecasting capabilities of the random forest method …
Spatial Roost Networks And Resource Selection Of Female Wild Turkeys, Nicholas W. Bakner, Erin E. Ulrey, Patrick H. Wightman, Nick A. Gulotta, Bret A. Collier, Michael J. Chamberlain
Spatial Roost Networks And Resource Selection Of Female Wild Turkeys, Nicholas W. Bakner, Erin E. Ulrey, Patrick H. Wightman, Nick A. Gulotta, Bret A. Collier, Michael J. Chamberlain
Faculty Publications
Wildlife demography is influenced by behavioural decisions, with sleep being a crucial avian behaviour. Avian species use roost sites to minimize thermoregulation costs, predation risk and enhance foraging efficiency. Sleep locations are often reused, forming networks within the home range. Our study, focusing on female eastern wild turkeys (Meleagris gallopavo silvestris) during the reproductive season, used social network analysis to quantify both roost site selection and network structure. We identified roost networks which were composed of a small percentage of hub roost sites connecting satellite roosts. Hub roosts were characterized by greater values of betweenness (β = 0.62, s.e. = …