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Development Of Functional Markers For Resistance To Smut And Identification Of Genes Differentially Expressed In Response To Brown Rust In Sugarcane, Jose David Cortes Dec 2022

Development Of Functional Markers For Resistance To Smut And Identification Of Genes Differentially Expressed In Response To Brown Rust In Sugarcane, Jose David Cortes

LSU Doctoral Dissertations

Smut, caused by Sporisorium scitamineum and brown rust, caused by Puccinia melanocephala, are two of the most important diseases that affect sugarcane production in Louisiana and worldwide. Smut continues to cause losses in the breeding program in Louisiana. Therefore, a QTL analysis was conducted to identify molecular markers associated with resistance in F1 progeny (162) of a biparental cross between susceptible cultivar L 99-233 and resistant HoCP 96-540. Using 1,574 single-dose SNP markers, a total of 253 linkage groups (LG) were obtained with a genome coverage of 24,580.15 cM. Six QTLs were localized on five LGs. The highest …

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A Subspecies-Level Database Of Amazonian Bird Distributions, With Inferences On Suture Zones And Conservation, Marco Antonio Rego Dec 2022

A Subspecies-Level Database Of Amazonian Bird Distributions, With Inferences On Suture Zones And Conservation, Marco Antonio Rego

LSU Doctoral Dissertations

Amazonia has the largest and most biodiverse tropical forest on the planet. However, the distributions of its species are still poorly understood, even for well-studied vertebrates such as birds. Available distribution maps for Amazonian birds often lack accuracy in delimiting the area where species occur. Existing distributional information for Amazonian birds is often limited to species-level level taxonomy, even though many Amazonian bird subspecies represent biological species. Here, I investigate the geographic distributions of 4,148 bird taxa (species and subspecies) using museum scientific specimens as the primary source of data. To build the data base I use more than 600,000 …

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Diet And Disturbance: Seaside Sparrow Resource Use Driven By Oiling And Hurricane Isaac, Allison M. Snider, Andrea Bonisoli-Alquati, Anna A. Pérez-Umphrey, Stefan Woltmann, Philip C. Stouffer, Sabrina S. Taylor Dec 2022

Diet And Disturbance: Seaside Sparrow Resource Use Driven By Oiling And Hurricane Isaac, Allison M. Snider, Andrea Bonisoli-Alquati, Anna A. Pérez-Umphrey, Stefan Woltmann, Philip C. Stouffer, Sabrina S. Taylor

Faculty Publications

The 2010 Deepwater Horizon (DWH) disaster led to extensive oil deposition in Louisiana’s coastal wetlands, followed two years later by Hurricane Isaac. These disturbances led to changes in saltmarsh invertebrate communities, potentially affecting higher-level predators and the saltmarsh food web. Seaside Sparrows (Ammospiza maritima) are ubiquitous, year-round residents of the coastal saltmarsh affected by the DWH spill, where they consume diverse invertebrates and may be considered an indicator species for the ecosystem’s integrity. We used DNA metabarcoding to evaluate prey consumed by Seaside Sparrows to understand how sparrows responded to residual contamination from the DWH oil spill and ecosystem disturbance …

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Programming The Properties Of Branched Polymers Through Precision Architectures, Michael R. Dearman Dec 2022

Programming The Properties Of Branched Polymers Through Precision Architectures, Michael R. Dearman

LSU Master's Theses

The glass transition of branched polymers is determined by multiple structural parameters that dictate their inter- and intramolecular interactions, and ultimately, their molecular packing in the amorphous phase. Here we examined the impact of side chain length, backbone length, molecular weight composition, and topology on the glass transition behavior of bottlebrush polymers. Through examining precision bottlebrush polymer libraries (PBP, ĐSC = 1.0), we find the infinite molecular weight Tg is reached at a specific brush length after which the effect of the side-chain length dominates. Being a factor more dominant than the backbone, side-chain length affects the Tg of bottlebrush …

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A Predictive Model Using The Mesoscopic Architecture Of The Living Brain To Detect Alzheimer’S Disease, Marianna Inglese, Neva Patel, Kristofer Linton-Reid, Flavia Loreto, Zarni Win, Richard J. Perry, Christopher Carswell, Matthew Grech-Sollars, William R. Crum, Haonan Lu, Paresh A. Malhotra, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Zbizek-Nulph, Joanne L. Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason Dec 2022

A Predictive Model Using The Mesoscopic Architecture Of The Living Brain To Detect Alzheimer’S Disease, Marianna Inglese, Neva Patel, Kristofer Linton-Reid, Flavia Loreto, Zarni Win, Richard J. Perry, Christopher Carswell, Matthew Grech-Sollars, William R. Crum, Haonan Lu, Paresh A. Malhotra, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Zbizek-Nulph, Joanne L. Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason

Clinical Research Faculty Publications

Background: Alzheimer’s disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care. Methods: We developed a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted MRI scans, with or without cognitive scores. For each patient, a biomarker called “Alzheimer’s Predictive Vector” (ApV) was derived using a two-stage least absolute shrinkage and selection operator (LASSO). Results: The ApV reliably discriminates between people with (ADrp) and without (nADrp) Alzheimer’s related pathologies (98% and 81% accuracy between ADrp - including the early form, mild …

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The Polygenic Risk Score Knowledge Base Offers A Centralized Online Repository For Calculating And Contextualizing Polygenic Risk Scores, Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T.W. Ebbert, L. Ravdin, M. Lin, A. Lee, G. Chiang, N. Relkin, R. B. Santulli, M. L. Hynes, M. Seltzer, L. A. Flashman, K. Anderson, K. Blank, G. D. Perlson, S. Kittur, S. Correia, P. Malloy, S. Salloway, S. Potkin, P. Newhouse, M. Sabbagh, A. Garcia, J. Shi, J. Masdeu, A. Williams, J. Mintzer, A. O’Connell, A. Mintz, D. Munic, C. Bernick Dec 2022

The Polygenic Risk Score Knowledge Base Offers A Centralized Online Repository For Calculating And Contextualizing Polygenic Risk Scores, Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T.W. Ebbert, L. Ravdin, M. Lin, A. Lee, G. Chiang, N. Relkin, R. B. Santulli, M. L. Hynes, M. Seltzer, L. A. Flashman, K. Anderson, K. Blank, G. D. Perlson, S. Kittur, S. Correia, P. Malloy, S. Salloway, S. Potkin, P. Newhouse, M. Sabbagh, A. Garcia, J. Shi, J. Masdeu, A. Williams, J. Mintzer, A. O’Connell, A. Mintz, D. Munic, C. Bernick

Clinical Research Faculty Publications

The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present a centralized polygenic risk score calculator currently containing over 250,000 genetic variant associations from the NHGRI-EBI GWAS Catalog for users to easily calculate sample-specific polygenic risk scores with comparable results to other available tools. Polygenic risk scores are calculated either online through the Polygenic Risk Score Knowledge Base (PRSKB; https://prs.byu.edu) or via a command-line interface. We report study-specific polygenic risk scores across the UK Biobank, 1000 Genomes, and the Alzheimer’s Disease …

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Total Energy Expenditure Is Repeatable In Adults But Not Associated With Short-Term Changes In Body Composition, Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Anderson, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk Dec 2022

Total Energy Expenditure Is Repeatable In Adults But Not Associated With Short-Term Changes In Body Composition, Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Anderson, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk

Clinical Research Faculty Publications

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but …

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Global-Scale Modeling Of Early Factors And Country-Specific Trajectories Of Covid-19 Incidence: A Cross-Sectional Study Of The First 6 Months Of The Pandemic, Sujoy Ghosh, Saikat Sinha Roy Dec 2022

Global-Scale Modeling Of Early Factors And Country-Specific Trajectories Of Covid-19 Incidence: A Cross-Sectional Study Of The First 6 Months Of The Pandemic, Sujoy Ghosh, Saikat Sinha Roy

Division of Basic Science Faculty Publications

Background: Studies examining factors responsible for COVID-19 incidence have been mostly focused at the national or sub-national level. A global-level characterization of contributing factors and temporal trajectories of disease incidence is currently lacking. Here we conducted a global-scale analysis of COVID-19 infections to identify key factors associated with early disease incidence. Additionally, we compared longitudinal trends of COVID-19 incidence at a per-country level, and classified countries based on COVID-19 incidence trajectories and effects of lockdown responses. Methods: This is an observational cross-sectional study covering COVID-19 incidence over the first 6 months of the pandemic (Jan 1, 2020 to June 30, …

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Redox Phospholipidomics Analysis Reveals Specific Oxidized Phospholipids And Regions In The Diabetic Mouse Kidney, Allison Mccrimmon, Sydney Corbin, Bindesh Shrestha, Gregory Roman, Suraj Dhungana, Krisztian Stadler Dec 2022

Redox Phospholipidomics Analysis Reveals Specific Oxidized Phospholipids And Regions In The Diabetic Mouse Kidney, Allison Mccrimmon, Sydney Corbin, Bindesh Shrestha, Gregory Roman, Suraj Dhungana, Krisztian Stadler

Division of Basic Science Faculty Publications

While it is generally accepted that oxidative stress impacts the diabetic kidney and contributes to pathogenesis, there is a substantial lack of knowledge about the molecular entity and anatomic location of a variety of reactive species. Here we provide a novel “oxidative stress map” of the diabetic kidney – the first of its kind, and identify specific, oxidized and other reactive lipids and their location. We used the db/db mouse model and Desorption Electrospray Ionization (DESI) mass spectrometry combined with heatmap image analysis. We analyzed a comprehensive array of phospholipid peroxide species in normal (db/m) and diabetic (db/db) kidneys using …

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Low Total Osteocalcin Levels Are Associated With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao Dec 2022

Low Total Osteocalcin Levels Are Associated With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao

Population and Public Health Science Faculty Publications

Background: The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data. Methods: We performed a retrospective cohort study of 9413 type 2 diabetic patients with at least three measurements of total serum osteocalcin within 3 years since their first inpatient diagnosis of type 2 diabetes. Baseline, mean values of osteocalcin levels and their trajectories were used as exposures. A multivariable-adjusted Cox proportional hazards model was used to estimate the association of osteocalcin levels and their trajectories with mortality. Results: During a …

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Extensive Morphological And Behavioural Diversity Among Fourteen New And Seven Described Species In Phytophthora Clade 10 And Its Evolutionary Implications, T. Jung, I. Milenković, T. Corcobado, T. Májek, J. Janoušek, T. Kudláček, M. Tomšovský, Z. Nagy, A. Durán, M. Tarigan, E. Sanfuentes Von Stowasser, R. Singh, M. Ferreira, J. F. Webber, B. Scanu, N. M. Chi, P. Q. Thu, M. Junaid, A. Rosmana, B. Baharuddin, T. Kuswinanti, N. Nasri, K. Kageyama, A. Hieno, H. Masuya, S. Uematsu, J. Oliva, M. Redondo, C. Maia, I. Matsiakh, V. Kramarets, R. O’Hanlon, Tomić Dec 2022

Extensive Morphological And Behavioural Diversity Among Fourteen New And Seven Described Species In Phytophthora Clade 10 And Its Evolutionary Implications, T. Jung, I. Milenković, T. Corcobado, T. Májek, J. Janoušek, T. Kudláček, M. Tomšovský, Z. Nagy, A. Durán, M. Tarigan, E. Sanfuentes Von Stowasser, R. Singh, M. Ferreira, J. F. Webber, B. Scanu, N. M. Chi, P. Q. Thu, M. Junaid, A. Rosmana, B. Baharuddin, T. Kuswinanti, N. Nasri, K. Kageyama, A. Hieno, H. Masuya, S. Uematsu, J. Oliva, M. Redondo, C. Maia, I. Matsiakh, V. Kramarets, R. O’Hanlon, Tomić

Faculty Publications

During extensive surveys of global Phytophthora diversity 14 new species detected in natural ecosystems in Chile, Indonesia, USA (Louisiana), Sweden, Ukraine and Vietnam were assigned to Phytophthora major Clade 10 based on a multigene phylogeny of nine nuclear and three mitochondrial gene regions. Clade 10 now comprises three subclades. Subclades 10a and 10b contain species with nonpapillate sporangia, a range of breeding systems and a mainly soil-and waterborne lifestyle. These include the previously described P. afrocarpa, P. gallica and P. intercalaris and eight of the new species: P. ludoviciana, P. procera, P. pseudogallica, P. scandinavica, P. subarctica, P. tenuimura, P. …

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Direct And Indirect Effects Of Planting Density, Nitrogenous Fertilizer And Host Plant Resistance On Rice Herbivores And Their Natural Enemies, Finbarr G. Horgan, Eduardo Crisol-Martínez, Alexander M. Stuart, James M. Villegas, Ainara Peñalver-Cruz, Enrique A. Mundaca, Marivic O. Perez, Carmencita C. Bernal, Maria Liberty P. Almazan, Angelee F. Ramal Dec 2022

Direct And Indirect Effects Of Planting Density, Nitrogenous Fertilizer And Host Plant Resistance On Rice Herbivores And Their Natural Enemies, Finbarr G. Horgan, Eduardo Crisol-Martínez, Alexander M. Stuart, James M. Villegas, Ainara Peñalver-Cruz, Enrique A. Mundaca, Marivic O. Perez, Carmencita C. Bernal, Maria Liberty P. Almazan, Angelee F. Ramal

Faculty Publications

In rice ecosystems, seeding densities can be adjusted to compensate for lower nitrogen levels that reduce GHG emissions, or to increase farm profitability. However, density-induced changes to plant anatomy could affect herbivore-rice interactions, and alter arthropod community dynamics. We conducted an experiment that varied transplanting density (low or high), nitrogenous fertilizer (0, 60 or 150 kg added ha−1) and rice variety (resistant or susceptible to phloem-feeding insects) over two rice-growing seasons. Yields per plot increased with added nitrogen, but were not affected by variety or transplanting density. Planthopper and leafhopper densities were lower on resistant rice and in high-density field …

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Examining The Symbioses Between Bioluminescent Vibrio Species And Ponyfishes In The Indian Ocean And Between Vibrio Species And Crassostrea Virginica In The Gulf Of Mexico, Alexandra Chauvin Dec 2022

Examining The Symbioses Between Bioluminescent Vibrio Species And Ponyfishes In The Indian Ocean And Between Vibrio Species And Crassostrea Virginica In The Gulf Of Mexico, Alexandra Chauvin

Honors Capstones

No abstract provided.

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Rejuvenation Improves The Quality Of Trichogramma Brassicae Bezdenko (Hymenoptera: Trichogrammatidae) Reared For Many Generations On Sitotroga Cerealella (Olivier) (Lepidoptera: Gelechiidae), Ehsan Ghaemmaghami, Yaghoub Fathipour, Abdoolnabi Bagheri, Ali Asghar Talebi, Gadi V.P. Reddy Dec 2022

Rejuvenation Improves The Quality Of Trichogramma Brassicae Bezdenko (Hymenoptera: Trichogrammatidae) Reared For Many Generations On Sitotroga Cerealella (Olivier) (Lepidoptera: Gelechiidae), Ehsan Ghaemmaghami, Yaghoub Fathipour, Abdoolnabi Bagheri, Ali Asghar Talebi, Gadi V.P. Reddy

Faculty Publications

Background: Domestication usually has negative effects on insect performance, especially when they are reared continuously for many generations. Rejuvenation can reduce the negative effects of domestication in the parasitoid, Trichogramma brassicae Bezdenko (Hymenoptera: Trichogrammatidae) reared for 30 generations (G) on Sitotroga cerealella (Olivier) (Lepidoptera: Gelechiidae). Life table and parasitism parameters in the primary colony (G31–G45) were compared with the respective colony rejuvenated with field-collected individuals. Results: There were significant differences in life history traits between domesticated and rejuvenated populations. The highest (38.4 eggs/female) and lowest (13.3 eggs/female) fecundity was observed in rejuvenated G31 and domesticated G45, respectively. The highest values …

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Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd Dec 2022

Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd

Division of Basic Science Faculty Publications

Background: Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared to 90% for well-differentiated liposarcoma (WDLPS). This discrepancy may be connected to their potential to form adipocytes, where WDLPS is adipogenic but DDLPS is adipogenic-impaired. Normal adipogenesis requires Zinc Finger Protein 423 (ZFP423), a transcriptional coregulator of Perixosome Proliferator Activated Receptor gamma (PPARG2) mRNA expression that defines committed preadipocytes. Expression of ZFP423 in preadipocytes is promoted by Seven-In-Absentia Homolog …

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Sk3 In Pomc Neurons Plays A Sexually Dimorphic Role In Energy And Glucose Homeostasis, Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang Dec 2022

Sk3 In Pomc Neurons Plays A Sexually Dimorphic Role In Energy And Glucose Homeostasis, Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang

Division of Basic Science Faculty Publications

Background: Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood. Results: We detected small conductance calcium-activated potassium (SK) current in POMC neurons. Secondary analysis of published single-cell RNA-Seq data showed that POMC neurons abundantly express SK3, one SK channel subunit. To test whether SK3 in POMC neurons regulates POMC neuron functions on energy and glucose homeostasis, we used a Cre-loxP strategy to delete SK3 specifically from mature POMC neurons. POMC-specific deletion of SK3 did not affect body weight in either …

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Covid-19 Vaccination Boosts The Potency And Breadth Of The Immune Response Against Sars-Cov-2 Among Recovered Patients In Wuhan, Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu, Yan Peng, Zhijun Zhou, Tao Deng, Jing Liu, Deming Ji, Ran Qiu, Lianzhen Lin, Yan Zeng, Fei Xia, Yong Hu, Taojing Li, Kai Duan, Xinguo Li, Zejun Wang, Yong Zhang, Hang Zhang, Chen Zhu, Shang Wang, Xiao Wu, Xiang Wang, Yuwei Li, Shihe Huang, Min Mao, Huanhuan Guo, Yunkai Yang, Rui Jia, Jingwei Xufang, Xuewei Wang Dec 2022

Covid-19 Vaccination Boosts The Potency And Breadth Of The Immune Response Against Sars-Cov-2 Among Recovered Patients In Wuhan, Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu, Yan Peng, Zhijun Zhou, Tao Deng, Jing Liu, Deming Ji, Ran Qiu, Lianzhen Lin, Yan Zeng, Fei Xia, Yong Hu, Taojing Li, Kai Duan, Xinguo Li, Zejun Wang, Yong Zhang, Hang Zhang, Chen Zhu, Shang Wang, Xiao Wu, Xiang Wang, Yuwei Li, Shihe Huang, Min Mao, Huanhuan Guo, Yunkai Yang, Rui Jia, Jingwei Xufang, Xuewei Wang

Division of Basic Science Faculty Publications

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited …

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Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin Dec 2022

Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin

Division of Basic Science Faculty Publications

Background: Patient-centred care is an important part of quality healthcare and patient satisfaction has been shown to be associated with improved clinical outcomes. We aim to explore the satisfaction of patients with diabetic kidney disease (DKD) with their visits to the TCM physician and its association with patients' socio-economic characteristics. Methods: A questionnaire survey was conducted among patients aged >21 years with DKD. Participants' demographic, socioeconomic characteristics and satisfaction scores measured with the self-administered Medical Interview Satisfaction Scale (MISS) were collected after they visited the TCM physician. MISS is a 26-item questionnaire consisting of three domains – cognitive, affective and …

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Ulk1 Inhibition Attenuates Telomerase Activity In Hepatic Cells, Sana Raza, Sangam Rajak, Jyotika Srivastava, Archana Tewari, Pratima Gupta, Bandana Chakravarti, Sujoy Ghosh, Chandra P. Chaturvedi, Rohit A. Sinha Dec 2022

Ulk1 Inhibition Attenuates Telomerase Activity In Hepatic Cells, Sana Raza, Sangam Rajak, Jyotika Srivastava, Archana Tewari, Pratima Gupta, Bandana Chakravarti, Sujoy Ghosh, Chandra P. Chaturvedi, Rohit A. Sinha

Division of Basic Science Faculty Publications

Autophagy and telomere maintenance are two cellular survival processes that show a strong correlation during human ageing and cancer growth, however, their causal relationship remains unclear. In this study, using an unbiased transcriptomics approach, we uncover a novel role of autophagy genes in regulating telomere extension and maintenance pathways. Concomitantly, the pharmacological inhibition of ULK1 (Unc-51 like autophagy activating kinase 1) attenuated human telomerase reverse transcriptase (hTERT) gene expression and telomerase activity in HepG2 cells. Furthermore, the suppression of telomerase activity upon ULK1 inhibition was associated with telomere shortening and onset of cellular senescence in HepG2 cells. These results, thus, …

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Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple Dec 2022

Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple

Faculty Publications

Geolocators are small devices that record and store time-stamped light levels that researchers typically use to approximate the latitude and longitude of small birds across the annual cycle. However, when geolocators are affixed to leg bands of larger-bodied birds, nest incubation by females interrupts the daily pattern of light and darkness. Thus, geolocators can provide information on nesting propensity, nest success, and renesting intensity; these demographic parameters are both difficult to measure unobtrusively and are critically important in determining population dynamics of birds, especially ducks. Here, we deployed 240 geolocators on mottled ducks Anas fulvigula in Louisiana and Texas in …

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Leaf Habit Affects The Distribution Of Drought Sensitivity But Not Water Transport Efficiency In The Tropics, German Vargas G., Norbert Kunert, William M. Hammond, Z. Carter Berry, Leland K. Werden, Chris M. Smith-Martin, Brett T. Wolfe, Laura Toro, Ariadna Mondragón-Botero, Jesús N. Pinto-Ledezma, Naomi B. Schwartz, María Uriarte, Lawren Sack, Kristina J. Anderson-Teixeira, Jennifer S. Powers Dec 2022

Leaf Habit Affects The Distribution Of Drought Sensitivity But Not Water Transport Efficiency In The Tropics, German Vargas G., Norbert Kunert, William M. Hammond, Z. Carter Berry, Leland K. Werden, Chris M. Smith-Martin, Brett T. Wolfe, Laura Toro, Ariadna Mondragón-Botero, Jesús N. Pinto-Ledezma, Naomi B. Schwartz, María Uriarte, Lawren Sack, Kristina J. Anderson-Teixeira, Jennifer S. Powers

Faculty Publications

Considering the global intensification of aridity in tropical biomes due to climate change, we need to understand what shapes the distribution of drought sensitivity in tropical plants. We conducted a pantropical data synthesis representing 1117 species to test whether xylem-specific hydraulic conductivity (KS), water potential at leaf turgor loss (ΨTLP) and water potential at 50% loss of KS (ΨP50) varied along climate gradients. The ΨTLP and ΨP50 increased with climatic moisture only for evergreen species, but KS did not. Species with high ΨTLP and ΨP50 values were associated with both dry and wet environments. However, drought-deciduous species showed high ΨTLP …

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Social Inequalities In Climate Change-Attributed Impacts Of Hurricane Harvey, Kevin T. Smiley, Ilan Noy, Michael F. Wehner, Dave Frame, Christopher C. Sampson, Oliver E.J. Wing Dec 2022

Social Inequalities In Climate Change-Attributed Impacts Of Hurricane Harvey, Kevin T. Smiley, Ilan Noy, Michael F. Wehner, Dave Frame, Christopher C. Sampson, Oliver E.J. Wing

Faculty Publications

Climate change is already increasing the severity of extreme weather events such as with rainfall during hurricanes. But little research to date investigates if, and to what extent, there are social inequalities in climate change-attributed extreme weather event impacts. Here, we use climate change attribution science paired with hydrological flood models to estimate climate change-attributed flood depths and damages during Hurricane Harvey in Harris County, Texas. Using detailed land-parcel and census tract socio-economic data, we then describe the socio-spatial characteristics associated with these climate change-induced impacts. We show that 30 to 50% of the flooded properties would not have flooded …

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Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni Dec 2022

Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni

Clinical Research Faculty Publications

Background: To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question is whether there is a definitive additional benefit of exercising at high intensity, in terms of slowing disease progression, beyond the well-documented benefit of endurance training on a treadmill for fitness, gait, and functional mobility. This study will determine the efficacy of high-intensity endurance exercise as first-line therapy for persons diagnosed with PD within 3 years, and untreated with symptomatic therapy at baseline. Methods: This is …

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Genetic Dissection Of Alkalinity Tolerance At The Seedling Stage In Rice (Oryza Sativa) Using A High-Resolution Linkage Map, Lovepreet Singh, Sapphire Coronejo, Rajat Pruthi, Sandeep Chapagain, Uttam Bhattarai, Prasanta K. Subudhi Dec 2022

Genetic Dissection Of Alkalinity Tolerance At The Seedling Stage In Rice (Oryza Sativa) Using A High-Resolution Linkage Map, Lovepreet Singh, Sapphire Coronejo, Rajat Pruthi, Sandeep Chapagain, Uttam Bhattarai, Prasanta K. Subudhi

Faculty Publications

Although both salinity and alkalinity result from accumulation of soluble salts in soil, high pH and ionic imbalance make alkaline stress more harmful to plants. This study aimed to provide molecular insights into the alkalinity tolerance using a recombinant inbred line (RIL) population developed from a cross between Cocodrie and Dular with contrasting response to alkalinity stress. Forty-six additive QTLs for nine morpho-physiological traits were mapped on to a linkage map of 4679 SNPs under alkalinity stress at the seedling stage and seven major-effect QTLs were for alkalinity tolerance scoring, Na+ and K+ concentrations and Na+:K+ ratio. The candidate genes …

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Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia Dec 2022

Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia

Population and Public Health Science Faculty Publications

Purpose This study aimed to describe longitudinal trends in children's moderate-to-vigorous physical activity (MVPA) and to investigate associations with individual, familial, and school characteristics. Methods A sample of 341 Portuguese children age 5-10 yr (173 girls) from six age cohorts was followed over 3 yr using a mixed-longitudinal design. Physical activity, body mass index (BMI), gross motor coordination, and musculoskeletal fitness were assessed annually. Information on socioeconomic status and school characteristics was collected and analyzed with mixed models. Results MVPA shows a similar declining trend in both sexes, but on average, boys exceeded the World Health Organization recommendations of 60 …

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Blocking Actriib And Restoring Appetite Reverses Cachexia And Improves Survival In Mice With Lung Cancer, Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R.M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves Dec 2022

Blocking Actriib And Restoring Appetite Reverses Cachexia And Improves Survival In Mice With Lung Cancer, Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R.M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves

Division of Basic Science Faculty Publications

Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous activity, and energy expenditure accompanied by muscle metabolic dysfunction and atrophy. We identify Activin A as a purported driver of cachexia and treat with ActRIIB-Fc, a decoy ligand for TGF-β/activin family members, together with anamorelin (Ana), a ghrelin receptor agonist, to reverse muscle dysfunction and anorexia, respectively. Ana effectively increases food intake but only the combination of drugs increases lean mass, restores spontaneous activity, and improves overall survival. These beneficial …

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Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas Dec 2022

Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas

Clinical Research Faculty Publications

Background: When a lifestyle intervention combines caloric restriction and increased physical activity energy expenditure (PAEE), there are two components of energy balance, energy intake (EI) and physical activity energy expenditure (PAEE), that are routinely misreported and expensive to measure. Energy balance models have successfully predicted EI if PAEE is known. Estimating EI from an energy balance model when PAEE is not known remains an open question. Objective: The objective was to evaluate the performance of an energy balance differential equation model to predict EI in an intervention that includes both calorie restriction and increases in PAEE. Design: The Antonetti energy …

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Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier Dec 2022

Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier

Division of Basic Science Faculty Publications

There have been multiple instances of novel pathogen emergence that have affected the health and security of the global community. To highlight that these novel pathogens presented a clear danger to public health, the WHO included “Disease X” on their list of priority pathogens in 2018. Indeed, since the emergence of SARS-CoV-2, Disease X has been pointed to as the looming threat of “the next big thing.” However, developing surveillance and preparedness plans with Disease X as the linchpin is too narrow and ignores a large swath of potential threats from already identified, often neglected diseases. We propose instead the …

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The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward Dec 2022

The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study used resting state fMRI data to analyze the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer’s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and …

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Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Dec 2022

Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected …

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