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Mathematics Library News, Aaron Lercher

Faculty Publications

Mathematics Library News is an LSU Libraries newsletter for members of the Mathematics and Experimental Statistics Departments, published roughly once each semester.

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Networks In Motion: The Alliances Of Information Communication Technologies And Mobility Technologies During The 1918 Influenza Pandemic, Miles C. Coleman, Will Mari

Faculty Publications

In this article, we turn back to the 1918 influenza pandemic to throw light on the alliances of information communication technologies and technologies of mobility (such as the car) during the pandemic. We examine newspaper articles, technical publications, and other historical texts to demonstrate that, despite the fact that mobile technologies—such as cellular phones—did not exist during the 1918 pandemic, the telephone and mobility technology nonetheless formed alliances as networks in motion, or social moments in which risk and reward are calculated not simply by the ability to move, but rather the ability to move, while remaining connected, revealing insight …

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Functional Domains Of The Hsv-1 Ul37 Protein In Virus Infectivity And Retrograde Transport In Neurons, Carolyn Clark

LSU Doctoral Dissertations

Herpes simplex virus type 1 is large alphaherpesvirus with 20 envelope proteins and 23 tegument proteins. Virus entry is via fusion of the viral envelope with cellular membranes mediated by a complex of viral glycoproteins. Glycoprotein B (gB) is the only fusogenic glycoprotein, while other viral glycoproteins and membrane proteins including gD, gH, gL, gK and UL20 membrane protein modulate gB’s fusogenicity. Previously, Our laboratory developed the HSV-1 (VC2) vaccines strain with partial deletions in the amino termini of gK (ΔgK(31–68)) and the UL20 membrane protein (ΔUL20(4–22)). VC2 enters epithelial cells only via endocytosis followed by release of the capsid …

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Optimization Of Host Cell-Compatible, Antimicrobial Peptides Effective Against Biofilms And Clinical Isolates Of Drug-Resistant Bacteria, Jenisha Ghimire, Robert J. Hart, Anabel Soldano, Charles H. Chen, Shantanu Guha, Joseph P. Hoffmann, Kalen M. Hall, Leisheng Sun, Benjamin J. Nelson, Timothy K. Lu, Jay K. Kolls, Mario Rivera, Lisa A. Morici, William C. Wimley

Faculty Publications

Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are variants of an evolved AMP called d-amino acid CONsensus with Glycine Absent (d-CONGA), which has excellent antimicrobial activities in vitro and in vivo. In this newest generation of rational d-CONGA variants, we tested multiple sequence-structure-function hypotheses that had not been tested in previous generations. Many of the peptide variants have lower antibacterial activity against Gram-positive or Gram-negative pathogens, especially variants that have altered hydrophobicity, secondary structure potential, or spatial …

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Cell-Specific Role Of Il4rα Signaling In Allergic Asthma, Ishita Choudhary

LSU Doctoral Dissertations

IL-4 and IL-13 play a critical role in allergic asthma pathogenesis via their common receptor, i.e., interleukin 4 receptor alpha (IL4Rα). However, the cell type-specific role of IL4Rα-mediated signaling in allergic asthma has remained unclear. We hypothesized that the role of IL4Rα signaling in allergic asthma is cell-type specific. To test our hypothesis, we challenged myeloid cell-specific IL4Rα-deficient (LysMcre^+/+/IL4Rα^fl/fl), myeloid cell-specific IL4Rα-sufficient (LysMcre^+/+/IL4Rα^wt/wt), airway epithelial cell-specific IL4Rα-deficient (CCSP-Cre⁺/IL4Rα^fl/fl), and airway epithelial cell-specific IL4Rα-sufficient (CCSP-Cre^-/IL4Rα^fl/fl) mice with either mixed allergens (MA) or normal saline three …

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The Regulation Of Autoimmunity Genes In Pancreatic Β-Cells By Nf-Κb, Thomas Malone Martin

LSU Doctoral Dissertations

Type 1 diabetes (T1D) is an autoimmune disease where the immune system targets the pancreatic islet beta-cells, which are responsible for insulin production and secretion, leading to a state of insulin insufficiency. Many of the molecular details of disease onset and progression remain poorly understood, including key aspects of cytokine signaling. Therefore, we have examined some of the consequences of inflammatory cytokine signaling as a critical module relevant to T1D. Using interleukin-1 (IL-1) signaling as a well-defined paradigm for inflammation, we investigated key components of this signaling pathway in pancreatic beta-cells. We identified ICAM-1, one of the proteins expressed in …

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Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson

Faculty Publications

Vibrios, such as Vibrio parahaemolyticus, are naturally occurring halophilic bacteria that are a major cause of foodborne illness. Because of their autochthonous nature, managing vibrio levels in marine and estuarine environments is impossible. Instead, it is crucial to reliably enumerate their abundance to minimize human exposure. One method of achieving this is the direct plating/colony hybridization (DP/CH) method, which has been used to efficiently quantify pathogenic vibrios in oysters and other seafood products. Although successful, the method relies on proprietary resources. We examined alternative approaches, assessed the influence of the reagent suppliers’ source on enumeration accuracy, and made experimental adjustments …

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Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith

Faculty Publications

Details of the structural elucidation of the clinically useful photodynamic therapy sensitizer NPe6 (15) are presented. NPe6, also designated as Laserphyrin, Talaporfin, and LS-11, is a second-generation photosensitizer derived from chlorophyll-a, currently used in Japan for the treatment of human lung, esophageal, and brain cancers. After the initial misidentification of the structure of this chlorin-e6 aspartic acid conjugate as (13), NMR and other synthetic procedures described herein arrived at the correct structure (15), confirmed using single crystal X-ray crystallography. Interesting new features of chlorin-e6 chemistry (including the intramolecular formation of an anhydride (24)) are reported, allowing chemists to regioselectively conjugate …

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Predicting Grocery Store Visits During The Early Outbreak Of Covid-19 With Machine Learning, Ruijie Bian, Pamela Murray-Tuite, Brian Wolshon

Faculty Publications

While non-essential travel was canceled during the coronavirus infectious disease (COVID-19) pandemic, grocery shopping was essential. The objectives of this study were to: 1) examine how grocery store visits changed during the early outbreak of COVID-19, and 2) estimate a model to predict the change of grocery store visits in the future, within the same phase of the pandemic. The study period (February 15–May 31, 2020) covered the outbreak and phase-one re-opening. Six counties/states in the United States were examined. Grocery store visits (in-store or curbside pickup) increased over 20% when the national emergency was declared on March 13 and …

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Rise Of The Metaverse's Immersive Virtual Reality Malware And The Man-In-The-Room Attack & Defenses, Martin Vondráček, Ibrahim Baggili, Peter Casey, Mehdi Mekni

Faculty Publications

The allure of the metaverse along with Virtual Reality (VR) technologies and speed at which they are deployed may shift focus away from security and privacy fundamentals. In this work we employ classic exploitation techniques against cutting edge devices to obtain equally novel results. The unique features of the Virtual Reality landscape set the stage for our primary account of a new attack, the Man-in-the-Room (MitR). This attack, realized from a vulnerable social networking application led to both worming and botnet capabilities being adapted for VR with potential critical impacts affecting millions of users. Our work improves the state-of-the-art in …

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Role Of Il-10 In Sars-Cov-2 Infection During Pregnancy, Natalie Lim

Honors Capstones

No abstract provided.

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Links Between Diversity And Composition Of The Avian Gut Microbiome And Resistance To Experimental Malaria Infection In House Sparrows (Passer Domesticus), Riley Noble

Honors Capstones

No abstract provided.

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From Nafta To The Usmca: How Does Protectionist American Economic Policy Impact Mexico’S Foreign Car Production?, Samantha Raeder

Honors Capstones

No abstract provided.

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Effect Of Nadph Oxidase On The Microbial And Chemical Contamination Of Water, Grace Sheets

Honors Capstones

No abstract provided.

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The Impacts Of Immune Challenges On Fish Behavior And Physiology, Teisha King

LSU Doctoral Dissertations

For species living in dominance hierarchies, social rank dictates access to resources and often contributes to reproductive success. To ensure survival, individuals constantly evaluate trade- offs between crucial biological systems, like the reproductive and immune systems, depending on their social rank and physiological state. Little is known about how social species balance interactions between immune system function, fluctuations in social status and reproductive fitness, and the performance of behaviors necessary for maintaining social status when sick, particularly in fishes, the largest and most diverse group of vertebrates. My dissertation research uses a whole animal approach to examine how physiological profiles …

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Betacoronaviruses Sars-Cov-2 And Hcov-Oc43 Infections In Igrov-1 Cell Line Require Aryl Hydrocarbon Receptor, Meisam Yousefi, Wai Suet Lee, Wharton O.Y. Chan, Wei He, Marcus G. Mah, Cythia Lingli Yong, Joshua M. Deerain, Lijin Wang, Camille Arcinas, Biaoguo Yan, Dewei Tan, Wan Rong Sia, Akshamal M. Gamage, Jinxuan Yang, Alan Chen Yu Hsu, Shang Li, Martin Linster, Xinglou Yang, Sujoy Ghosh, Danielle E. Anderson, Gavin J.D. Smith, Chee Wah Tan, Lin Fa Wang, Yaw Shin Ooi

Division of Basic Science Faculty Publications

The emergence of novel betacoronaviruses has posed significant financial and human health burdens, necessitating the development of appropriate tools to combat future outbreaks. In this study, we have characterized a human cell line, IGROV-1, as a robust tool to detect, propagate, and titrate betacoronaviruses SARS-CoV-2 and HCoV-OC43. IGROV-1 cells can be used for serological assays, antiviral drug testing, and isolating SARS-CoV-2 variants from patient samples. Using time-course transcriptomics, we confirmed that IGROV-1 cells exhibit a robust innate immune response upon SARS-CoV-2 infection, recapitulating the response previously observed in primary human nasal epithelial cells. We performed genome-wide CRISPR knockout genetic screens …

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Obesity: A Disease Of Overnutrition, George A. Bray, Catherine M. Champagne

Population and Public Health Science Faculty Publications

Obesity is a serious worldwide problem that is increasing in prevalence. Obesity results from increased energy intake from food exceeding what is needed for daily energy expenditure over a considerable period of time. Obesity predicts the risk for many diseases, including diabetes, liver and gall bladder disease, infectious diseases such as SARSCov-19, and heart disease, among others. Treatments for obesity include diet, exercise, behavioral therapy, medications, and surgery.

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Core Issues, Case Studies, And The Need For Expanded Legacy African American Genomics, Fatimah Jackson, Carter Clinton, Jennifer Caldwell

Population and Public Health Science Faculty Publications

Introduction: Genomic studies of Legacy African Americans have a tangled and convoluted history in western science. In this review paper, core issues affecting African American genomic studies are addressed and two case studies, the New York African Burial Ground and the Gullah Geechee peoples, are presented to highlight the current status of genomic research among Africa Americans. Methods: To investigate our target population’s core issues, a metadatabase derived from 22 publicly accessible databases were reviewed, evaluated, and synthesized to identify the core bioethical issues prevalent during the centuries of the African American presence in North America. The sequence of metadatabase …

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Identification Of Oral Therapeutics Using An Ai Platform Against The Virus Responsible For Covid-19, Sars-Cov-2, Adam Bess, Frej Berglind, Supratik Mukhopadhyay, Michal Brylinski, Chris Alvin, Fanan Fattah, Kishor M. Wasan

Faculty Publications

Purpose: This study introduces a sophisticated computational pipeline, eVir, designed for the discovery of antiviral drugs based on their interactions within the human protein network. There is a pressing need for cost-effective therapeutics for infectious diseases (e.g., COVID-19), particularly in resource-limited countries. Therefore, our team devised an Artificial Intelligence (AI) system to explore repurposing opportunities for currently used oral therapies. The eVir system operates by identifying pharmaceutical compounds that mirror the effects of antiviral peptides (AVPs)—fragments of human proteins known to interfere with fundamental phases of the viral life cycle: entry, fusion, and replication. eVir extrapolates the probable antiviral efficacy …

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Reconsidering The Good Of Improving Accountability, Roy L. Heidelberg

Faculty Publications

Among the rhetorical pleas that follow most instances of public dissatisfaction is the call for more or better accountability. Accountability is a lauded notion, a “golden concept” that is considered widely as critical to the success of democratic government. Such pleas, I will argue, are misplaced. Rather than starting from the premise of accountability as an idea that no one can be against, I consider the possibility that accountability undermines the very notion it ostensibly promotes: self-government. The concept of accountability in modern political theory is tied more closely to the emergence of an impersonal administrative state than it is …

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Show Us The Data: Global Covid-19 Wastewater Monitoring Efforts, Equity, And Gaps, Colleen C. Naughton, Fernando A. Roman, Ana Grace F. Alvarado, Arianna Q. Tariqi, Matthew A. Deeming, Krystin F. Kadonsky, Kyle Bibby, Aaron Bivins, Gertjan Medema, Warish Ahmed, Panagis Katsivelis, Vajra Allan, Ryan Sinclair, Joan B. Rose

Faculty Publications

A year since the declaration of the global coronavirus disease 2019 (COVID-19) pandemic, there were over 110 million cases and 2.5 million deaths. Learning from methods to track community spread of other viruses such as poliovirus, environmental virologists and those in the wastewater-based epidemiology (WBE) field quickly adapted their existing methods to detect SARS-CoV-2 RNA in wastewater. Unlike COVID-19 case and mortality data, there was not a global dashboard to track wastewater monitoring of SARS-CoV-2 RNA worldwide. This study provides a 1-year review of the “COVIDPoops19” global dashboard of universities, sites, and countries monitoring SARS-CoV-2 RNA in wastewater. Methods to …

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Aircraft Wastewater Surveillance For Early Detection Of Sars-Cov-2 Variants — John F. Kennedy International Airport, New York City, August–September 2022, Robert C. Morfino, Stephen M. Bart, Andrew Franklin, Benjamin H. Rome, Andrew P. Rothstein, Thomas W.S. Aichele, Siyao Lisa Li, Aaron Bivins, Ezra T. Ernst, Cindy R. Friedman

Faculty Publications

No abstract provided.

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Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier

Division of Basic Science Faculty Publications

There have been multiple instances of novel pathogen emergence that have affected the health and security of the global community. To highlight that these novel pathogens presented a clear danger to public health, the WHO included “Disease X” on their list of priority pathogens in 2018. Indeed, since the emergence of SARS-CoV-2, Disease X has been pointed to as the looming threat of “the next big thing.” However, developing surveillance and preparedness plans with Disease X as the linchpin is too narrow and ignores a large swath of potential threats from already identified, often neglected diseases. We propose instead the …

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Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana

Faculty Publications

Probiotics are commonly added to yogurt to provide many health benefits for the consumer. A description is provided for some commonly used probiotics in yogurt. A GRAS (generally recognized as safe) list of probiotic bacteria that can be added to yogurt or similar types of products is provided. Additionally, prebiotics, synbiotics (combination of prebiotics and probiotics), postbiotics, paraprobiotics, and psychobiotics can be added to yogurt. Probiotic yogurt can come in various forms in addition to spoonable yogurt, and yogurt can be used as an ingredient in other food products. Many useful functional ingredients can be applied to probiotic yogurt. The …

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Role Of Cd38 In Pulmonary Host Defense Against Gram-Negative Pneumonia, Xiaoqian Shan

LSU Master's Theses

The Gram-negative bacterium, Klebsiella pneumoniae, is a major cause of hospital-acquired pneumonia in the U.S. In particular, the dramatic increase in carbapenem-resistant K. pneumoniae infections poses a serious threat to the public health both in the United States and worldwide. Clearance of bacteria in the lungs depends on effective pulmonary immune response. It may be possible to design improved therapies that augment host immune responses while attenuating excessive pulmonary inflammation through modulation of key innate immunity molecules during pneumonic infections. Cluster differentiation CD38 (CD38) has been detected on the surface of many immune cells or intracellular compartments, acting as …

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A Membrane Transporter Required For Quorum Sensing And Virulence Of The Rice Pathogen Burkholderia Glumae, Asif Iqbal

LSU Doctoral Dissertations

Burkholderia glumae is a Gram-negative bacterium causing bacterial panicle blight (BPB) in rice. BPB can cause severe damage to rice and reduce rice yield up to 75%, while no effective treatment has been developed to control the disease. B. glumae produces and secretes an essential virulence factor, toxoflavin, which is mainly responsible for the symptoms of BPB. Synthesis and transport of toxoflavin are regulated in a quorum-sensing dependent manner. Members of the DedA superfamily are putative membrane transporters and found in nearly all species. Mutation of dedA in Burkholderia species results in sensitivity to colistin, an antibiotic belonging to the …

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Social Influences On Physical Activity For Establishing Criteria Leading To Exercise Persistence, Ensela Mema, Everett S. Spain, Corby K. Martin, James O. Hill, R. Drew Sayer, Howard D. Mcinvale, Lee A. Evans, Nicholas H. Gist, Alexander D. Borowsky, Diana M. Thomas

Clinical Research Faculty Publications

Despite well-documented health benefits from exercise, a study on national trends in achieving the recommended minutes of physical activity guidelines has not improved since the guidelines were published in 2008. Peer interactions have been identified as a critical factor for increasing a population’s physical activity. The objective of this study is for establishing criteria for social influences on physical activity for establishing criteria that lead to exercise persistence. A system of differential equations was developed that projects exercise trends over time. The system includes both social and non-social influences that impact changes in physical activity habits and establishes quantitative conditions …

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Estimating R0 From Early Exponential Growth: Parallels Between 1918 Influenza And 2020 Sars-Cov-2 Pandemics, Grant Foster, Bret D. Elderd, Robert L. Richards, Tad Dallas

Faculty Publications

The large spatial scale, geographical overlap, and similarities in transmission mode between the 1918 H1N1 influenza and 2020 SARS-CoV-2 pandemics together provide a novel opportunity to investigate relationships between transmission of two different diseases in the same location. To this end, we use initial exponential growth rates in a Bayesian hierarchical framework to estimate the basic reproductive number, R0, of both disease outbreaks in a common set of 43 cities in the United States. By leveraging multiple epidemic time series across a large spatial area, we are able to better characterize the variation in R0 across the United States. Additionally, …

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Developing A Conceptual Passive Contact Tracing System For Commercial Buildings Using Wifi Indoor Positioning, Sorena Vosoughkhosravi, Amirhosein Jafari

Faculty Publications

Contact tracing is one of the critical tools for fighting against pandemic disease outbreaks, such as the fast-growing SARS-CoV-2 virus and its different variants. At present, automated contact tracing systems face two main challenges: (1) requiring application installation on smart devices and (2) protecting the users’ privacy. This study introduces a conceptual passive contact tracing system using indoor WiFi positioning to address these challenges and investigate the role of such a system in commercial buildings. In this regard, this study uses a simulated small-office layout in a case study to demonstrate the applicability of the proposed system. The special use …

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The Curve Not Taken: Effects Of Covid-19 International Comparison News, Seon Woo Kim, Martina Santia, Raymond J. Pingree, Ayla Oden, Kirill Bryanov, Jessica Wyers

Faculty Publications

International news can inform people not only about what is happening in other countries, but also about how their own country could benefit from policies that have proved successful elsewhere. Specifically, international policy comparison news, or news that compares the policies of two or more countries on the same issue, is a potentially important but underutilized and understudied form of news content. We use an experiment to test effects of exposure to news comparing the COVID-19 pandemic policies of the U.S. versus South Korea, and find that this increases knowledge of policy differences between the two countries, support for adopting …

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Full-Text Articles in Entire DC Network

Mathematics Library News, Aaron Lercher

Faculty Publications

Networks In Motion: The Alliances Of Information Communication Technologies And Mobility Technologies During The 1918 Influenza Pandemic, Miles C. Coleman, Will Mari

Faculty Publications

Functional Domains Of The Hsv-1 Ul37 Protein In Virus Infectivity And Retrograde Transport In Neurons, Carolyn Clark

LSU Doctoral Dissertations

Faculty Publications

Cell-Specific Role Of Il4rα Signaling In Allergic Asthma, Ishita Choudhary

LSU Doctoral Dissertations

The Regulation Of Autoimmunity Genes In Pancreatic Β-Cells By Nf-Κb, Thomas Malone Martin

LSU Doctoral Dissertations

Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson

Faculty Publications

Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith

Faculty Publications

Predicting Grocery Store Visits During The Early Outbreak Of Covid-19 With Machine Learning, Ruijie Bian, Pamela Murray-Tuite, Brian Wolshon

Faculty Publications

Rise Of The Metaverse's Immersive Virtual Reality Malware And The Man-In-The-Room Attack & Defenses, Martin Vondráček, Ibrahim Baggili, Peter Casey, Mehdi Mekni

Faculty Publications

Role Of Il-10 In Sars-Cov-2 Infection During Pregnancy, Natalie Lim

Honors Capstones

Links Between Diversity And Composition Of The Avian Gut Microbiome And Resistance To Experimental Malaria Infection In House Sparrows (Passer Domesticus), Riley Noble

Honors Capstones

From Nafta To The Usmca: How Does Protectionist American Economic Policy Impact Mexico’S Foreign Car Production?, Samantha Raeder

Honors Capstones

Effect Of Nadph Oxidase On The Microbial And Chemical Contamination Of Water, Grace Sheets

Honors Capstones

The Impacts Of Immune Challenges On Fish Behavior And Physiology, Teisha King

LSU Doctoral Dissertations

Division of Basic Science Faculty Publications

Obesity: A Disease Of Overnutrition, George A. Bray, Catherine M. Champagne

Population and Public Health Science Faculty Publications

Core Issues, Case Studies, And The Need For Expanded Legacy African American Genomics, Fatimah Jackson, Carter Clinton, Jennifer Caldwell

Population and Public Health Science Faculty Publications

Identification Of Oral Therapeutics Using An Ai Platform Against The Virus Responsible For Covid-19, Sars-Cov-2, Adam Bess, Frej Berglind, Supratik Mukhopadhyay, Michal Brylinski, Chris Alvin, Fanan Fattah, Kishor M. Wasan

Faculty Publications

Reconsidering The Good Of Improving Accountability, Roy L. Heidelberg

Faculty Publications

Faculty Publications

Faculty Publications

Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier

Division of Basic Science Faculty Publications

Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana

Faculty Publications

Role Of Cd38 In Pulmonary Host Defense Against Gram-Negative Pneumonia, Xiaoqian Shan

LSU Master's Theses

A Membrane Transporter Required For Quorum Sensing And Virulence Of The Rice Pathogen Burkholderia Glumae, Asif Iqbal

LSU Doctoral Dissertations

Social Influences On Physical Activity For Establishing Criteria Leading To Exercise Persistence, Ensela Mema, Everett S. Spain, Corby K. Martin, James O. Hill, R. Drew Sayer, Howard D. Mcinvale, Lee A. Evans, Nicholas H. Gist, Alexander D. Borowsky, Diana M. Thomas

Clinical Research Faculty Publications

Estimating R0 From Early Exponential Growth: Parallels Between 1918 Influenza And 2020 Sars-Cov-2 Pandemics, Grant Foster, Bret D. Elderd, Robert L. Richards, Tad Dallas

Faculty Publications

Developing A Conceptual Passive Contact Tracing System For Commercial Buildings Using Wifi Indoor Positioning, Sorena Vosoughkhosravi, Amirhosein Jafari

Faculty Publications

The Curve Not Taken: Effects Of Covid-19 International Comparison News, Seon Woo Kim, Martina Santia, Raymond J. Pingree, Ayla Oden, Kirill Bryanov, Jessica Wyers

Faculty Publications