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Predicting Antibiotic Resistance In Recreational Areas, Daniela Azevedo Apr 2024

Predicting Antibiotic Resistance In Recreational Areas, Daniela Azevedo

Honors Capstones

No abstract provided.

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Aggressive Behaviors Related To Delirium In Hospitalized Older Adults: A Systematic Review, Julia D. Trahan Mar 2024

Aggressive Behaviors Related To Delirium In Hospitalized Older Adults: A Systematic Review, Julia D. Trahan

LSU Master's Theses

This is a systematic review of the aggressive behaviors related to delirium in hospitalized older adults. The objective of this study was to review relevant literature regarding the moderation of delirious related aggressive behaviors within a hospital setting and examining the extent of interventions being conducted with aggression being a main factor. The eligibility factors for studies to be included were as follows: diagnosis of delirium, aggressive behaviors or agitation present, study occurring within a hospital setting, the goal of preventing aggressive behaviors, and participants must be over the age of 65. Academic Search Complete, PsychINFO, MEDLINE, SocINDEX, CINHAL Complete …

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Claudin-1 As A Novel Target Gene Induced In Obesity And Associated To Inflammation, Fibrosis, And Cell Differentiation, Pablo Fernández-García, Siri D. Taxerås, Marjorie Reyes-Farias, Lorena González, Andrea Soria-Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Jacqueline M. Stephens, Lindsey G. Yoo, María Galán, Adriana Izquierdo, Gema Medina-Gómez, Laura Herrero, Patricia Corrales, Francesc Villarroya, Rubén Cereijo, David Sánchez-Infantes Mar 2024

Claudin-1 As A Novel Target Gene Induced In Obesity And Associated To Inflammation, Fibrosis, And Cell Differentiation, Pablo Fernández-García, Siri D. Taxerås, Marjorie Reyes-Farias, Lorena González, Andrea Soria-Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Jacqueline M. Stephens, Lindsey G. Yoo, María Galán, Adriana Izquierdo, Gema Medina-Gómez, Laura Herrero, Patricia Corrales, Francesc Villarroya, Rubén Cereijo, David Sánchez-Infantes

Division of Basic Science Faculty Publications

Objective: T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in tight junctions and tissue paracellular permeability. We evaluated T-lymphocyte gene expression in vWAT and sWAT and in the whole adipose depots in human samples. Methods: A Clariom D-based transcriptomic analysis was performed on T lymphocytes magnetically separated from vWAT and sWAT from patients with obesity (Cohort 1; N = 11). Expression of candidate genes resulting from that analysis …

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Planetary Protection Knowledge Gap Closure Enabling Crewed Missions To Mars, James A. Spry, Bette Siegel, Corien Bakermans, David W. Beaty, Mary Sue Bell, James N. Benardini, Rosalba Bonaccorsi, Sarah L. Castro-Wallace, David A. Coil, Athena Coustenis, Peter T. Doran, Lori Fenton, David P. Fidler, Brian Glass, Stephen J. Hoffman, Fathi Karouia, Joel S. Levine, Mark L. Lupisella, Javier Martin-Torres, Rakesh Mogul, Karen Olsson-Francis, Sandra Ortega-Ugalde, Manish R. Patel, David A. Pearce, Margaret S. Race, Aaron B. Regberg, Petra Rettberg, John D. Rummel, Kevin Y. Sato, Andrew C. Schuerger, Elliot Sefton-Nash, Matthew Sharkey, Nitin K. Singh Mar 2024

Planetary Protection Knowledge Gap Closure Enabling Crewed Missions To Mars, James A. Spry, Bette Siegel, Corien Bakermans, David W. Beaty, Mary Sue Bell, James N. Benardini, Rosalba Bonaccorsi, Sarah L. Castro-Wallace, David A. Coil, Athena Coustenis, Peter T. Doran, Lori Fenton, David P. Fidler, Brian Glass, Stephen J. Hoffman, Fathi Karouia, Joel S. Levine, Mark L. Lupisella, Javier Martin-Torres, Rakesh Mogul, Karen Olsson-Francis, Sandra Ortega-Ugalde, Manish R. Patel, David A. Pearce, Margaret S. Race, Aaron B. Regberg, Petra Rettberg, John D. Rummel, Kevin Y. Sato, Andrew C. Schuerger, Elliot Sefton-Nash, Matthew Sharkey, Nitin K. Singh

Faculty Publications

As focus for exploration of Mars transitions from current robotic explorers to development of crewed missions, it remains important to protect the integrity of scientific investigations at Mars, as well as protect the Earth's biosphere from any potential harmful effects from returned martian material. This is the discipline of planetary protection, and the Committee on Space Research (COSPAR) maintains the consensus international policy and guidelines on how this is implemented. Based on National Aeronautics and Space Administration (NASA) and European Space Agency (ESA) studies that began in 2001, COSPAR adopted principles and guidelines for human missions to Mars in 2008. …

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Simultaneous Detection And Quantification Of Multiple Pathogen Targets In Wastewater, Gouthami Rao, Drew Capone, Kevin Zhu, Abigail Knoble, Yarrow Linden, Ryan Clark, Amanda Lai, Juhee Kim, Ching Hua Huang, Aaron Bivins, Joe Brown Feb 2024

Simultaneous Detection And Quantification Of Multiple Pathogen Targets In Wastewater, Gouthami Rao, Drew Capone, Kevin Zhu, Abigail Knoble, Yarrow Linden, Ryan Clark, Amanda Lai, Juhee Kim, Ching Hua Huang, Aaron Bivins, Joe Brown

Faculty Publications

Wastewater-based epidemiology has emerged as a critical tool for public health surveillance, building on decades of environmental surveillance work for pathogens such as poliovirus. Work to date has been limited to monitoring a single pathogen or small numbers of pathogens in targeted studies; however, few studies consider simultaneous quantitative analysis of a wide variety of pathogens, which could greatly increase the utility of wastewater surveillance. We developed a novel quantitative multi-pathogen surveillance approach (35 pathogen targets including bacteria, viruses, protozoa, and helminths) using TaqMan Array Cards (TAC) and applied the method on concentrated wastewater samples collected at four wastewater treatment …

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The Lavatory Lens: Tracking The Global Movement Of Pathogens Via Aircraft Wastewater, Aaron Bivins, Robert Morfino, Andrew Franklin, Stuart Simpson, Warish Ahmed Jan 2024

The Lavatory Lens: Tracking The Global Movement Of Pathogens Via Aircraft Wastewater, Aaron Bivins, Robert Morfino, Andrew Franklin, Stuart Simpson, Warish Ahmed

Faculty Publications

Modern commercial air travel connects disparate human populations. The global airline industry transported as many as 4.5 billion passengers annually in the years leading up to the COVID-19 pandemic. While such connections are convenient for commerce and tourism, air travel networks can also be efficient distributors of infectious diseases. During the COVID-19 pandemic, public health agencies used multi-layered control strategies to manage the risk of COVID-19 transmission associated with air travel. Simultaneously, the surveillance of aircraft wastewater was further developed as a promising new method to screen for COVID-19, including newly emerging lineages, among international travelers. Herein, we review the …

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Editorial: How Rsv Outsmarts The Host, Stephania A. Cormier, Lawrence M. Kauvar, Ralph A. Tripp Jan 2024

Editorial: How Rsv Outsmarts The Host, Stephania A. Cormier, Lawrence M. Kauvar, Ralph A. Tripp

Division of Basic Science Faculty Publications

No abstract provided.

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Exploring Older Adults’ Mobility Challenges And Preferences Before And After Experiencing Covid-19 Pandemic, Hany Hassan, Bernard Boakye Jan 2024

Exploring Older Adults’ Mobility Challenges And Preferences Before And After Experiencing Covid-19 Pandemic, Hany Hassan, Bernard Boakye

Publications

The US Census Bureau reports that the number of seniors (65+ years old) in the US is predicted to increase from 16.5% in 2019 to 22% by 2050. However, seniors have reduced mobility as they age due to their declining health and the limited travel options available. Therefore, it is crucial to solve their transportation needs during pandemics like COVID-19 when they are most disadvantaged. This study involved an online national survey that collected 1507 responses from seniors in all the 50 US states to examine their travel behavior and challenges and their willingness to adopt Autonomous Vehicles before and …

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Are We Adequately Training Our Healthcare Providers Facing The Pandemic Of Obesity?, Eric Ravussin Jan 2024

Are We Adequately Training Our Healthcare Providers Facing The Pandemic Of Obesity?, Eric Ravussin

Clinical Research Faculty Publications

No abstract provided.

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Advancing Health Equity: The Role Of A Community–Academic–Public Health–Practice (Capp) Partnership In Addressing Covid-19 Disparities In Louisiana, John Mcclure, Lee Mendoza, Theresa Sokol, Davondra Brown, Thomas Laveist, Sandra Brown, Erin Peacock, La Keisha Williams, David Mushatt, Peter Katzmarzyk, Daniel Sarpong, Marie Krousel-Wood Jan 2024

Advancing Health Equity: The Role Of A Community–Academic–Public Health–Practice (Capp) Partnership In Addressing Covid-19 Disparities In Louisiana, John Mcclure, Lee Mendoza, Theresa Sokol, Davondra Brown, Thomas Laveist, Sandra Brown, Erin Peacock, La Keisha Williams, David Mushatt, Peter Katzmarzyk, Daniel Sarpong, Marie Krousel-Wood

Population and Public Health Science Faculty Publications

We assessed the impact of an innovative Louisiana community–academic–public health–practice (CAPP) partnership in addressing COVID-19–associated Black–White vaccination disparities over 19 months. Initially (April 2021), the cumulative vaccinations for Black versus White Louisianans were 54 542 per 100 000 versus 62 435 per 100 000, respectively. By October 2022, cumulative vaccinations for Black versus White Louisianans were 142 437 per 100 000 versus 132 488 per 100 000, respectively. The vaccination equity score increased from 908 out of 1000 in April 2021 to 942 out of 1000 in October 2022. CAPP partnership efforts contributed to addressing initial Black–White COVID-19 vaccination disparities. …

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Updates In Air Pollution: Current Research And Future Challenges, Dwan Vilcins, Rebecca C. Christofferson, Jin Ho Yoon, Siti Nurshahida Nazli, Peter D. Sly, Stephania A. Cormier, Guofeng Shen Jan 2024

Updates In Air Pollution: Current Research And Future Challenges, Dwan Vilcins, Rebecca C. Christofferson, Jin Ho Yoon, Siti Nurshahida Nazli, Peter D. Sly, Stephania A. Cormier, Guofeng Shen

Division of Basic Science Faculty Publications

Background: The United Nations has declared that humans have a right to clean air. Despite this, many deaths and disability-adjusted life years are attributed to air pollution exposure each year. We face both challenges to air quality and opportunities to improve, but several areas need to be addressed with urgency. Objective: This paper summarises the recent research presented at the Pacific Basin Consortium for Environment and Health Symposium and focuses on three key areas of air pollution that are important to human health and require more research. Findings and conclusion: Indoor spaces are commonly places of exposure to poor air …

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Th2 And Th17-Associated Immunopathology Following Sars-Cov-2 Breakthrough Infection In Spike-Vaccinated Ace2-Humanized Mice, Tianyi Zhang, Nicholas Magazine, Michael C. Mcgee, Mariano Carossino, Gianluca Veggiani, Konstantin G. Kousoulas, Avery August, Weishan Huang Jan 2024

Th2 And Th17-Associated Immunopathology Following Sars-Cov-2 Breakthrough Infection In Spike-Vaccinated Ace2-Humanized Mice, Tianyi Zhang, Nicholas Magazine, Michael C. Mcgee, Mariano Carossino, Gianluca Veggiani, Konstantin G. Kousoulas, Avery August, Weishan Huang

Faculty Publications

Vaccines have demonstrated remarkable effectiveness in protecting against COVID-19; however, concerns regarding vaccine-associated enhanced respiratory diseases (VAERD) following breakthrough infections have emerged. Spike protein subunit vaccines for SARS-CoV-2 induce VAERD in hamsters, where aluminum adjuvants promote a Th2-biased immune response, leading to increased type 2 pulmonary inflammation in animals with breakthrough infections. To gain a deeper understanding of the potential risks and the underlying mechanisms of VAERD, we immunized ACE2-humanized mice with SARS-CoV-2 Spike protein adjuvanted with aluminum and CpG-ODN. Subsequently, we exposed them to increasing doses of SARS-CoV-2 to establish a breakthrough infection. The vaccine elicited robust neutralizing antibody …

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The Effect Of Covid-19 Lockdown On Traffic Crashes In Texas., Hatim Sharif, Samer Dessouky Jan 2024

The Effect Of Covid-19 Lockdown On Traffic Crashes In Texas., Hatim Sharif, Samer Dessouky

Publications

An analysis of traffic patterns during COVID-19 has identified that reduction in the miles traveled has a significant negative correlation with COVID-19 cases and deaths across the USA. Preliminary statistics in the US suggest an increase in fatal crashes over the period of the lockdown in comparison to the same period in previous years. Moreover, while total crashes are down, motor vehicle crashes involving non-motorists became more prevalent. At the same time, non-motorist traffic has increased while motor vehicle traffic and crashes have shifted to the local systems. The main goal of this research is to perform a comprehensive evaluation …

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A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel Dec 2023

A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel

Faculty Publications

Mosquitoes are a known public nuisance and can vector various diseases. Historically, New Orleans, LA, has long been acquainted with the burden of mosquito-borne diseases, such as malaria and yellow fever in the 20th century and West Nile virus in the 21st century. Government mosquito control awareness campaigns have been around for decades as has the use of organophosphate and pyrethroid insecticides by mosquito abatement districts. However, few data are available on public perception of mosquito control and public usage of insecticides to kill mosquitoes in New Orleans. We conducted a survey from August 2020 to July 2021 to evaluate …

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An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina Dec 2023

An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina

Clinical Research Faculty Publications

Background: Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more frequent among PLWH and increases the risk of health challenges. PLWH with at-risk alcohol use are more likely to meet criteria for prediabetes/diabetes and this is associated with impaired whole-body glucose-insulin dynamics. Methods: The Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions Study (ALIVE-Ex Study, NCT03299205) is a longitudinal, prospective, interventional study to determine the effects of an aerobic exercise protocol on improving dysglycemia among PLWH with at-risk alcohol use. The intervention …

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Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel Dec 2023

Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel

Population and Public Health Science Faculty Publications

No abstract provided.

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Improving Cellphone-Based Bio-Imaging Technique For Fluorescence Detection, Erteza T. Efaz Nov 2023

Improving Cellphone-Based Bio-Imaging Technique For Fluorescence Detection, Erteza T. Efaz

LSU Master's Theses

The research presented in this thesis focuses on the design, development, and evaluation of a fluorescence detection system. The system is implemented primarily as an Android application, Auto Camera, which leverages smartphone cameras to capture and analyze fluorescent images. The application provides a user-friendly interface with some configurable features like exposure time, ISO speed, and storage limit; as well as defining detection thresholds and setting acquisition intervals. This study begins with the architectural framework of the Android application, which is written in Java using Android Studio. The API compatibility is set to version 33, and users are prompted to grant …

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Investigations Of Emerging Zoonotic And Vector-Borne Viruses At The Juncture Of Environmental, Human, And Animal Health, Erik A. Turner Nov 2023

Investigations Of Emerging Zoonotic And Vector-Borne Viruses At The Juncture Of Environmental, Human, And Animal Health, Erik A. Turner

LSU Doctoral Dissertations

Reemerging and emerging zoonotic viruses are some of the most important public and One Health threats facing the world. Understanding the transmission dynamics of these viruses is vital to reducing the disease burden, and one of the key aspects to these transmission systems is the environmental vertex of the One Health triangle. SARS-CoV-2 has only recently emerged as a global public health threat, and within 4 years, over 700 million cases have been reported. As a novel pathogen, many aspects of transmission, including environmental fomite transmission and disinfection, were initially a glaring gap in knowledge. Additionally, while chikungunya virus (CHIKV) …

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A Membrane Protein Of The Rice Pathogen Burkholderia Glumae Required For Oxalic Acid Secretion And Quorum Sensing, Asif Iqbal, George Nwokocha, Vijay Tiwari, Inderjit K. Barphagha, Anne Grove, Jong Hyun Ham, William T. Doerrler Nov 2023

A Membrane Protein Of The Rice Pathogen Burkholderia Glumae Required For Oxalic Acid Secretion And Quorum Sensing, Asif Iqbal, George Nwokocha, Vijay Tiwari, Inderjit K. Barphagha, Anne Grove, Jong Hyun Ham, William T. Doerrler

Faculty Publications

Bacterial panicle blight is caused by Burkholderia glumae and results in damage to rice crops worldwide. Virulence of B. glumae requires quorum sensing (QS)-dependent synthesis and export of toxoflavin, responsible for much of the damage to rice. The DedA family is a conserved membrane protein family found in all bacterial species. B. glumae possesses a member of the DedA family, named DbcA, which we previously showed is required for toxoflavin secretion and virulence in a rice model of infection. B. glumae secretes oxalic acid as a “common good” in a QS-dependent manner to combat toxic alkalinization of the growth medium …

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Strength Training Is More Effective Than Aerobic Exercise For Improving Glycaemic Control And Body Composition In People With Normal-Weight Type 2 Diabetes: A Randomised Controlled Trial, Yukari Kobayashi, Jin Long, Shozen Dan, Neil M. Johannsen, Ruth Talamoa, Sonia Raghuram, Sukyung Chung, Kyla Kent, Marina Basina, Cynthia Lamendola, Francois Haddad, Mary B. Leonard, Timothy S. Church, Latha Palaniappan Oct 2023

Strength Training Is More Effective Than Aerobic Exercise For Improving Glycaemic Control And Body Composition In People With Normal-Weight Type 2 Diabetes: A Randomised Controlled Trial, Yukari Kobayashi, Jin Long, Shozen Dan, Neil M. Johannsen, Ruth Talamoa, Sonia Raghuram, Sukyung Chung, Kyla Kent, Marina Basina, Cynthia Lamendola, Francois Haddad, Mary B. Leonard, Timothy S. Church, Latha Palaniappan

Clinical Research Faculty Publications

Aims/hypothesis: Type 2 diabetes in people in the healthy weight BMI category (< 25 kg/m2), herein defined as ‘normal-weight type 2 diabetes’, is associated with sarcopenia (low muscle mass). Given this unique body composition, the optimal exercise regimen for this population is unknown. Methods: We conducted a parallel-group RCT in individuals with type 2 diabetes (age 18–80 years, HbA1c 47.5–118.56 mmol/mol [6.5–13.0%]) and BMI < 25 kg/m2). Participants were recruited in outpatient clinics or through advertisements and randomly assigned to a 9 month exercise programme of strength training alone (ST), aerobic training alone (AER) or both interventions combined (COMB). We used stratified block randomisation with a randomly selected block size. Researchers and caregivers were blinded to participants’ treatment group; however, participants themselves were not. Exercise interventions were conducted at community-based fitness centres. The primary outcome was absolute change in HbA1c level within and across the three groups at 3, 6 and 9 months. Secondary outcomes included changes in body composition at 9 months. Per adherence to recommended exercise protocol (PP) analysis included participants who completed at least 50% of the sessions. Results: Among 186 individuals (ST, n=63; AER, n=58; COMB, n=65) analysed, the median (IQR) age was 59 (53–66) years, 60% were men and 83% were Asian. The mean (SD) HbA1c level at baseline was 59.6 (13.1) mmol/mol (7.6% [1.2%]). In intention-to-treat analysis, the ST group showed a significant decrease in HbA1c levels (mean [95% CI] −0.44 percentage points [−0.78, −0.12], p=0.002), while no significant change was observed in either the COMB group (−0.35 percentage points, p=0.13) or the AER group (−0.24 percentage points, p=0.10). The ST group had a greater improvement in HbA1c levels than the AER group (p=0.01). Appendicular lean mass relative to fat mass increased only in the ST group (p=0.0008), which was an independent predictor of HbA1c change (beta coefficient −7.16, p=0.01). Similar results were observed in PP analysis. Only one adverse event, in the COMB group, was considered to be possibly associated with the exercise intervention. Conclusions/interpretation: In normal-weight type 2 diabetes, strength training was superior to aerobic training alone, while no significant difference was observed between strength training and combination training for HbA1c reduction. Increased lean mass relative to decreased fat mass was an independent predictor of reduction in HbA1c level. Trial registration: ClinicalTrials.gov NCT02448498. Funding: This study was funded by the National Institutes of Health (NIH; R01DK081371). Graphical Abstract: [Figure not available: see fulltext.].

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Structured Ethical Review For Wastewater-Based Testing In Support Of Public Health, Devin A. Bowes, Amanda Darling, Erin M. Driver, Devrim Kaya, Rasha Maal-Bared, Lisa M. Lee, Kenneth Goodman, Sangeet Adhikari, Srijan Aggarwal, Aaron Bivins, Zuzana Bohrerova, Alasdair Cohen, Claire Duvallet, Rasha A. Elnimeiry, Justin M. Hutchison, Vikram Kapoor, Ishi Keenum, Fangqiong Ling, Deborah Sills, Ananda Tiwari, Peter Vikesland, Ryan Ziels, Cresten Mansfeldt Sep 2023

Structured Ethical Review For Wastewater-Based Testing In Support Of Public Health, Devin A. Bowes, Amanda Darling, Erin M. Driver, Devrim Kaya, Rasha Maal-Bared, Lisa M. Lee, Kenneth Goodman, Sangeet Adhikari, Srijan Aggarwal, Aaron Bivins, Zuzana Bohrerova, Alasdair Cohen, Claire Duvallet, Rasha A. Elnimeiry, Justin M. Hutchison, Vikram Kapoor, Ishi Keenum, Fangqiong Ling, Deborah Sills, Ananda Tiwari, Peter Vikesland, Ryan Ziels, Cresten Mansfeldt

Faculty Publications

Wastewater-based testing (WBT) for SARS-CoV-2 has rapidly expanded over the past three years due to its ability to provide a comprehensive measurement of disease prevalence independent of clinical testing. The development and simultaneous application of WBT measured biomarkers for research activities and for the pursuit of public health goals, both areas with well-established ethical frameworks. Currently, WBT practitioners do not employ a standardized ethical review process, introducing the potential for adverse outcomes for WBT professionals and community members. To address this deficiency, an interdisciplinary workshop developed a framework for a structured ethical review of WBT. The workshop employed a consensus …

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Trends In Gestational Weight Gain In Louisiana, March 2019 To March 2022, Emily W. Harville, Chelsea L. Kracht, Nicole L. Cohen, Elizabeth F. Sutton, Maryam Kebbe, Leanne M. Redman Aug 2023

Trends In Gestational Weight Gain In Louisiana, March 2019 To March 2022, Emily W. Harville, Chelsea L. Kracht, Nicole L. Cohen, Elizabeth F. Sutton, Maryam Kebbe, Leanne M. Redman

Clinical Research Faculty Publications

IMPORTANCE Average gestational weight gain (GWG) increased during the COVID-19 pandemic, but it is not known whether this trend has continued. OBJECTIVE To examine patterns of GWG during the COVID-19 pandemic by delivery and conception timing through the second year of the pandemic. DESIGN, SETTING, AND PARTICIPANTS This cohort study is a retrospective review of birth certificate and delivery records from 2019 to 2022. Electronic health records were from the largest delivery hospital in Louisiana. Participants included all individuals giving birth from March 2019 to March 2022. Data analysis was performed from October 2022 to July 2023. EXPOSURE Delivery date …

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Evaluating Vaccine Management Strategies For Edwardsiella Ictaluri Infections In Zebrafish (Danio Rerio), Brandy Malbrough Jul 2023

Evaluating Vaccine Management Strategies For Edwardsiella Ictaluri Infections In Zebrafish (Danio Rerio), Brandy Malbrough

LSU Master's Theses

Aquaculture is a globally important industry that faces significant challenges due to infectious diseases, which can result in substantial financial losses. In 2011, a new strain of Edwardsiella ictaluri emerged as a major pathogen affecting zebrafish in the ornamental fish industry, leading to high mortality rates and posing a severe threat to the sector. Vaccines provide potential benefits for disease prevention in aquaculture, particularly live-attenuated vaccines (LAVs), which induce strong host immune responses. Bacterial attenuation for vaccine development has evolved from serial passage to more targeted genetic modification techniques. However, regulatory constraints limit the availability of licensed LAVs for aquaculture. …

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Influence Of Membrane Pore-Size On The Recovery Of Endogenous Viruses From Wastewater Using An Adsorption-Extraction Method, Warish Ahmed, Wendy J.M. Smith, Kwanrawee Sirikanchana, Masaaki Kitajima, Aaron Bivins, Stuart L. Simpson Jul 2023

Influence Of Membrane Pore-Size On The Recovery Of Endogenous Viruses From Wastewater Using An Adsorption-Extraction Method, Warish Ahmed, Wendy J.M. Smith, Kwanrawee Sirikanchana, Masaaki Kitajima, Aaron Bivins, Stuart L. Simpson

Faculty Publications

The ongoing COVID-19 pandemic has emphasized the significance of wastewater surveillance in monitoring and tracking the spread of infectious diseases, including SARS-CoV-2. The wastewater surveillance approach detects genetic fragments from viruses in wastewater, which could provide an early warning of outbreaks in communities. In this study, we determined the concentrations of four types of endogenous viruses, including non-enveloped DNA (crAssphage and human adenovirus 40/41), non-enveloped RNA (enterovirus), and enveloped RNA (SARS-CoV-2) viruses, from wastewater samples using the adsorption-extraction (AE) method with electronegative HA membranes of different pore sizes (0.22, 0.45, and 0.80 µm). Our findings showed that the membrane with …

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Exploring Barriers To Sars-Cov-2 Testing Uptake In Underserved Black Communities In Louisiana, Peter T. Katzmarzyk, Candice A. Myers, Michelle R. Nelson, Kara D. Denstel, Emily F. Mire, Robert L. Newton, Stephanie T. Broyles, John P. Kirwan Jul 2023

Exploring Barriers To Sars-Cov-2 Testing Uptake In Underserved Black Communities In Louisiana, Peter T. Katzmarzyk, Candice A. Myers, Michelle R. Nelson, Kara D. Denstel, Emily F. Mire, Robert L. Newton, Stephanie T. Broyles, John P. Kirwan

Division of Basic Science Faculty Publications

Objective: To collect qualitative data on approaches that can potentially reduce barriers to, and create strategies for, increasing SARS-CoV-2 testing uptake in underserved Black communities in Louisiana. Methods: A series of eight focus groups, including 41 participants, were conducted in primarily Black communities. The Nominal Group Technique (NGT) was used to determine perceptions of COVID-19 as a disease, access to testing, and barriers limiting testing uptake. Results: Common barriers to SARS-CoV-2 testing were identified as lack of transportation, misinformation/lack of information, lack of time/long wait times, fear of the test being uncomfortable and/or testing positive, the cost of testing, and …

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Three-Dimensional Scaffolds For Bone Tissue Engineering, Harish Chinnasami, Mohan Kumar Dey, Ram Devireddy Jul 2023

Three-Dimensional Scaffolds For Bone Tissue Engineering, Harish Chinnasami, Mohan Kumar Dey, Ram Devireddy

Faculty Publications

Immobilization using external or internal splints is a standard and effective procedure to treat minor skeletal fractures. In the case of major skeletal defects caused by extreme trauma, infectious diseases or tumors, the surgical implantation of a bone graft from external sources is required for a complete cure. Practical disadvantages, such as the risk of immune rejection and infection at the implant site, are high in xenografts and allografts. Currently, an autograft from the iliac crest of a patient is considered the “gold standard” method for treating large-scale skeletal defects. However, this method is not an ideal solution due to …

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Toward One Health: A Spatial Indicator System To Model The Facilitation Of The Spread Of Zoonotic Diseases, Daniel Jato-Espino, Fernando Mayor-Vitoria, Vanessa Moscardó, Fabio Capra-Ribeiro, Leticia Bartolome Del Pino Jun 2023

Toward One Health: A Spatial Indicator System To Model The Facilitation Of The Spread Of Zoonotic Diseases, Daniel Jato-Espino, Fernando Mayor-Vitoria, Vanessa Moscardó, Fabio Capra-Ribeiro, Leticia Bartolome Del Pino

Faculty Publications

Recurrent outbreaks of zoonotic infectious diseases highlight the importance of considering the interconnections between human, animal, and environmental health in disease prevention and control. This has given rise to the concept of One Health, which recognizes the interconnectedness of between human and animal health within their ecosystems. As a contribution to the One Health approach, this study aims to develop an indicator system to model the facilitation of the spread of zoonotic diseases. Initially, a literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to identify relevant indicators related to One Health. The …

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Design, Construction, And Testing Of Recombinant Dna-Based Vaccines For Protection Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Ashley Edwards Jun 2023

Design, Construction, And Testing Of Recombinant Dna-Based Vaccines For Protection Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Ashley Edwards

LSU Doctoral Dissertations

In the United States, Salmonella Javiana is among the top 5 most common nontyphoidal Salmonella serotypes, with a 325% increase in infection rate since 1970. Globally, nontyphoidal Salmonella leads to approximately 93.8 million illnesses and 155,000 deaths annually, with disproportionate impacts in developing countries. In the United States alone, these infections lead to over $4 billion in costs, the majority of which are attributed to those expenses incurred from mortalities. The zoonotic nature of nontyphoidal Salmonellae and their ability to survive on and within vegetation mean huge economic burden potential for various agricultural industries as well, especially since some of …

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Researching Covid To Enhance Recovery (Recover) Adult Study Protocol: Rationale, Objectives, And Design, Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine S. Cicek, Megan L. Fitzgerald, Jason D. Goldman, Rachel Hess, S. L. Hodder, Vanessa L. Jacoby, Michael R. Jordan, Jerry A. Krishnan, Adeyinka O. Laiyemo, Torri D. Metz, Lauren Nichols, Rachel E. Patzer, Anisha Sekar, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Shifa Ahmed, Heather A. Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V. Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie Abele C. Bind, Lora J. Black, Andra L. Blomkalns, Hassan Brim, Mario Castro, James Chan Jun 2023

Researching Covid To Enhance Recovery (Recover) Adult Study Protocol: Rationale, Objectives, And Design, Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine S. Cicek, Megan L. Fitzgerald, Jason D. Goldman, Rachel Hess, S. L. Hodder, Vanessa L. Jacoby, Michael R. Jordan, Jerry A. Krishnan, Adeyinka O. Laiyemo, Torri D. Metz, Lauren Nichols, Rachel E. Patzer, Anisha Sekar, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Shifa Ahmed, Heather A. Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V. Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie Abele C. Bind, Lora J. Black, Andra L. Blomkalns, Hassan Brim, Mario Castro, James Chan

Division of Basic Science Faculty Publications

Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. …

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Exploring The Experiences Of Pregnant Women In The U.S. During The First Year Of The Covid-19 Pandemic, Courtney E. Williams, Dana Berkowitz, Heather M. Rackin Jun 2023

Exploring The Experiences Of Pregnant Women In The U.S. During The First Year Of The Covid-19 Pandemic, Courtney E. Williams, Dana Berkowitz, Heather M. Rackin

Faculty Publications

In this paper, we integrate the stress process model with symbolic interactionism to frame our analysis of interviews with 35 women who were pregnant and/or gave birth during the first year of the Covid-19 pandemic. We detail three stressors, highlight their variation, and discuss how they coped with these stressors. Women reported having to navigate contradictory information about the public health crisis, but Black participants simultaneously endured added strain from a heightened awareness of racialized violence. To cope with an overabundance of precarious and contradictory messages, some women sought out information (i.e., information gatherers), others eschewed information (i.e., information avoiders), …

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