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Articles 91 - 120 of 819
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The Thermodynamics Of A Stochastic Geometry Model With Applications To Non-Extensive Statistics, O.K. Kazemi, A. Pourdarvish, J. Sadeghi
The Thermodynamics Of A Stochastic Geometry Model With Applications To Non-Extensive Statistics, O.K. Kazemi, A. Pourdarvish, J. Sadeghi
Journal of Stochastic Analysis
No abstract provided.
Gis Automated Delineation And Analysis Of Cancer Service Areas In The United States, Changzhen Wang
Gis Automated Delineation And Analysis Of Cancer Service Areas In The United States, Changzhen Wang
LSU Doctoral Dissertations
Delineating a meaningful and reliable geographic unit pertaining to cancer care is essential in examining geographic variations in cancer care for better analysis, management, and planning. Public health researchers have devoted great efforts to defining various service areas, which; however, lack scientific rigor or are unrepresentative of the highly specialized cancer care markets, and their methods have become obsolete in the era of big data and high geo-computation. This study develops the “Spatially Constrained Leiden (ScLeiden)” method, a network community detection algorithm in Geographic Information Systems (GIS), and applies it to delineate a series of coherent cancer service …
Evaluation Of Residual Antibacterial Effects On Canine Skin Surface And Hairs Following Treatment With Five Commercial Mousse Products Against Staphylococcus Pseudintermedius In Vitro, Chi-Yen Wu
LSU Master's Theses
Topical products are essential treatments for canine superficial bacterial folliculitis. However, studies for commercial products typically evaluate antibacterial effects on hairs rather than the skin surface. In addition, the interference from the hair length has not been evaluated in these studies. Therefore, the study objective for this study was to evaluate the residual antibacterial effects of five mousse products, (1) 2% chlorhexidine and 2% miconazole, (2) 0.05% phytosphingosine, (3) 2% salicylic acid and 10% ethyl lactate, (4) 3% chlorhexidine and 0.5% climbazole, and (5) 2% chlorhexidine and 1% ketoconazole on both the skin surface and hairs in both short- and …
Event Based Approach For Modeling Indoor Airflow Patterns, Ehsan Mousavi, Arup Bhattacharya
Event Based Approach For Modeling Indoor Airflow Patterns, Ehsan Mousavi, Arup Bhattacharya
Faculty Publications
People spend a significant proportion of their time indoors, where the quality of indoor air affects the productivity, efficiency, and well-being of occupants. One of the oldest challenges in building construction is designing a ventilation system that ensures optimum indoor air quality. Acceptable indoor air should provide thermal comfort and minimize human exposure to contamination. Characterizing these two elements requires information on both heat/mass transfer in the microenvironment and the time-specific activity of individuals who move among these microenvironments. While researchers have utilized simulation tools to investigate this complex human-environment interaction, current numerical techniques severely limit the simulations to overly …
Special Issue: Emerging Paradigms In Insulin Resistance, J. Jason Collier, Susan J. Burke
Special Issue: Emerging Paradigms In Insulin Resistance, J. Jason Collier, Susan J. Burke
Division of Basic Science Faculty Publications
No abstract provided.
'My Name Is Peaches': Black Women's Affect In The Blues Biomyth, Taylor C. Scott
'My Name Is Peaches': Black Women's Affect In The Blues Biomyth, Taylor C. Scott
LSU Doctoral Dissertations
For this project, I am interested in the study of nuanced self-representations of Black rage that appear within African American literary traditions, specifically the blues aesthetic, wherein artists narrativize a wide spectrum of intelligent and specific emotion--not just melancholy. Blues narratives in which Black people self-represent are in direct opposition to flattened narratives of certain affective modes such as anger as a useless, backwards, pathologized, and flat feeling that appear within dominant U.S. and global iconographies. What I see in the blues aesthetic is the capacity for a multichromatic approach to studying rage and Black authorship in America. By using …
Industrial Construction Safety Policies And Practices With Cost Impacts In A Covid-19 Pandemic Environment: A Louisiana Dow Case Study, Brian Briggs, Carol J. Friedland, Isabelina Nahmens, Charles Berryman, Yimin Zhu
Industrial Construction Safety Policies And Practices With Cost Impacts In A Covid-19 Pandemic Environment: A Louisiana Dow Case Study, Brian Briggs, Carol J. Friedland, Isabelina Nahmens, Charles Berryman, Yimin Zhu
Faculty Publications
There are always significant challenges in improving the safety culture by changing and adding additional safety protocols. The unknown impacts of COVID-19 and how it quickly spreads led the industry to institute essential safety protocols. This paper addresses two problem statements. The first problem statement is: what are the additional safety protocols for process safety, construction & maintenance, and personal protective equipment requirements? The second problem statement is: what are the cost and schedule impacts of industrial construction projects resulting from implementing safety protocols and process safety during construction with the added PPE? While complying with added safety protocols, the …
Potent Anti-Sars-Cov-2 Efficacy Of Covid-19 Hyperimmune Globulin From Vaccine-Immunized Plasma, Ding Yu, Yu Feng Li, Hong Liang, Jun Zheng Wu, Yong Hu, Yan Peng, Tao Jing Li, Ji Feng Hou, Wei Jin Huang, Li Dong Guan, Ren Han, Yan Tao Xing, Yong Zhang, Jia Liu, Lu Feng, Chun Yan Li, Xiao Long Liang, Ya Ling Ding, Zhi Jun Zhou, De Ming Ji, Fei Fei Wang, Jian Hong Yu, Kun Deng, Dong Mei Xia, De Mei Dong, Heng Rui Hu, Ya Jie Liu, Dao Xing Fu, Yan Lin He, Dong Bo Zhou, Hui Chuan Yang, Rui Jia, Chang Wen Ke, Tao Du
Potent Anti-Sars-Cov-2 Efficacy Of Covid-19 Hyperimmune Globulin From Vaccine-Immunized Plasma, Ding Yu, Yu Feng Li, Hong Liang, Jun Zheng Wu, Yong Hu, Yan Peng, Tao Jing Li, Ji Feng Hou, Wei Jin Huang, Li Dong Guan, Ren Han, Yan Tao Xing, Yong Zhang, Jia Liu, Lu Feng, Chun Yan Li, Xiao Long Liang, Ya Ling Ding, Zhi Jun Zhou, De Ming Ji, Fei Fei Wang, Jian Hong Yu, Kun Deng, Dong Mei Xia, De Mei Dong, Heng Rui Hu, Ya Jie Liu, Dao Xing Fu, Yan Lin He, Dong Bo Zhou, Hui Chuan Yang, Rui Jia, Chang Wen Ke, Tao Du
Division of Basic Science Faculty Publications
Coronavirus disease 2019 (COVID-19) remains a global public health threat. Hence, more effective and specific antivirals are urgently needed. Here, COVID-19 hyperimmune globulin (COVID-HIG), a passive immunotherapy, is prepared from the plasma of healthy donors vaccinated with BBIBP-CorV (Sinopharm COVID-19 vaccine). COVID-HIG shows high-affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, the receptor-binding domain (RBD), the N-terminal domain of the S protein, and the nucleocapsid protein; and blocks RBD binding to human angiotensin-converting enzyme 2 (hACE2). Pseudotyped and authentic virus-based assays show that COVID-HIG displays broad-spectrum neutralization effects on a wide variety of SARS-CoV-2 variants, …
Bridging The Research Gap Between Live Collections In Zoos And Preserved Collections In Natural History Museums, Sinlan Poo, Steven M. Whitfield, Alexander Shepack, Gregory J. Watkins-Colwell, Gil Nelson, Jillian Goodwin, Allison Bogisich, Patricia L.R. Brennan, Jennifer D'Agostino, Michelle S. Koo, Joseph R. Mendelson, Rebecca Snyder, Sandra Wilson, Gary P. Aronsen, Andrew C. Bentley, David C. Blackburn, Matthew R. Borths, Mariel L. Campbell, Dalia A. Conde, Joseph A. Cook, Juan D. Daza, Daniel P. Dembiec, Jonathan L. Dunnum, Catherine M. Early, Adam W. Ferguson, Amanda Greene, Robert Guralnick, Courtney Janney, Debbie Johnson, Felicia Knightly, Stephane Poulin, Luiz Rocha, Pamela S. Soltis
Bridging The Research Gap Between Live Collections In Zoos And Preserved Collections In Natural History Museums, Sinlan Poo, Steven M. Whitfield, Alexander Shepack, Gregory J. Watkins-Colwell, Gil Nelson, Jillian Goodwin, Allison Bogisich, Patricia L.R. Brennan, Jennifer D'Agostino, Michelle S. Koo, Joseph R. Mendelson, Rebecca Snyder, Sandra Wilson, Gary P. Aronsen, Andrew C. Bentley, David C. Blackburn, Matthew R. Borths, Mariel L. Campbell, Dalia A. Conde, Joseph A. Cook, Juan D. Daza, Daniel P. Dembiec, Jonathan L. Dunnum, Catherine M. Early, Adam W. Ferguson, Amanda Greene, Robert Guralnick, Courtney Janney, Debbie Johnson, Felicia Knightly, Stephane Poulin, Luiz Rocha, Pamela S. Soltis
Faculty Publications
Zoos and natural history museums are both collections-based institutions with important missions in biodiversity research and education. Animals in zoos are a repository and living record of the world's biodiversity, whereas natural history museums are a permanent historical record of snapshots of biodiversity in time. Surprisingly, despite significant overlap in institutional missions, formal partnerships between these institution types are infrequent. Life history information, pedigrees, and medical records maintained at zoos should be seen as complementary to historical records of morphology, genetics, and distribution kept at museums. Through examining both institution types, we synthesize the benefits and challenges of cross-institutional exchanges …
Louisiana Certified Child Life Specialists’ Perspective On The Effects Of Covid-19 On Child Life Services, Abby Johnson
Louisiana Certified Child Life Specialists’ Perspective On The Effects Of Covid-19 On Child Life Services, Abby Johnson
LSU Master's Theses
The medical field has faced challenges throughout the COVID-19 pandemic, significantly changing the ways hospitals function and healthcare professionals serve patients and families. Healthcare professionals, specifically Certified Child Life Specialists (CCLSs), have continuously adapted their roles, programs, and services to ensure they adhere to the ever-changing infection control policies and mitigation efforts put in place by government officials and institutions. CCLSs provide pediatric patients and their families with interventions, hospital normalization, and opportunities to engage in play, contributing to pediatric patients’ healing environment during hospitalization. This study focuses on pediatric healthcare in the state of Louisiana, gaining insight from CCLSs’ …
Environment And Co-Occurring Native Mussel Species, But Not Host Genetics, Impact The Microbiome Of A Freshwater Invasive Species (Corbicula Fluminea), Marlène Chiarello, Jamie R. Bucholz, Mark Mccauley, Stephanie N. Vaughn, Garrett W. Hopper, Irene Sánchez González, Carla L. Atkinson, Jeffrey D. Lozier, Colin R. Jackson
Environment And Co-Occurring Native Mussel Species, But Not Host Genetics, Impact The Microbiome Of A Freshwater Invasive Species (Corbicula Fluminea), Marlène Chiarello, Jamie R. Bucholz, Mark Mccauley, Stephanie N. Vaughn, Garrett W. Hopper, Irene Sánchez González, Carla L. Atkinson, Jeffrey D. Lozier, Colin R. Jackson
Faculty Publications
The Asian clam Corbicula fluminea (Family: Cyneridae) has aggressively invaded freshwater habitats worldwide, resulting in dramatic ecological changes and declines of native bivalves such as freshwater mussels (Family: Unionidae), one of the most imperiled faunal groups. Despite increases in our knowledge of invasive C. fluminea biology, little is known of how intrinsic and extrinsic factors, including co-occurring native species, influence its microbiome. We investigated the gut bacterial microbiome across genetically differentiated populations of C. fluminea in the Tennessee and Mobile River Basins in the Southeastern United States and compared them to those of six co-occurring species of native freshwater mussels. …
Artificial Intelligence For The Discovery Of Novel Antimicrobial Agents For Emerging Infectious Diseases, A Bess, F Berglind, S Mukhopadhyay, M Brylinski, A Bess, T F. Cho, C Galliano, K M. Wasan
Artificial Intelligence For The Discovery Of Novel Antimicrobial Agents For Emerging Infectious Diseases, A Bess, F Berglind, S Mukhopadhyay, M Brylinski, A Bess, T F. Cho, C Galliano, K M. Wasan
Faculty Publications
The search for effective drugs to treat new and existing diseases is a laborious one requiring a large investment of capital, resources, and time. The coronavirus 2019 (COVID-19) pandemic has been a painful reminder of the lack of development of new antimicrobial agents to treat emerging infectious diseases. Artificial intelligence (AI) and other in silico techniques can drive a more efficient, cost friendly approach to drug discovery by helping move potential candidates with better clinical tolerance forward in the pipeline. Several research teams have developed successful AI platforms for hit identification, lead generation, and lead optimization. In this review, we …
Examining The Role Of Bullshit Receptivity On Covid-19 Vaccination Behaviors, Erica L. Leonard
Examining The Role Of Bullshit Receptivity On Covid-19 Vaccination Behaviors, Erica L. Leonard
Honors Capstones
No abstract provided.
Wetlands In China: Evolution, Carbon Sequestrations And Services, Threats, And Preservation/Restoration, Siyuan Ye, Lixin Pei, Lei He, Liujuan Xie, Guangming Zhao, Hongming Yuan, Xigui Ding, Shaofeng Pei, Shixiong Yang, Xue Li, Edward Laws
Wetlands In China: Evolution, Carbon Sequestrations And Services, Threats, And Preservation/Restoration, Siyuan Ye, Lixin Pei, Lei He, Liujuan Xie, Guangming Zhao, Hongming Yuan, Xigui Ding, Shaofeng Pei, Shixiong Yang, Xue Li, Edward Laws
Faculty Publications
No abstract provided.
Wetlands In China: Evolution, Carbon Sequestrations And Services, Threats, And Preservation/Restoration, Siyuan Ye, Lixin Pei, Lei He, Liujuan Xie, Guangming Zhao, Hongming Yuan, Xigui Ding, Shaofeng Pei, Shixiong Yang, Xue Li, Edward Laws
Wetlands In China: Evolution, Carbon Sequestrations And Services, Threats, And Preservation/Restoration, Siyuan Ye, Lixin Pei, Lei He, Liujuan Xie, Guangming Zhao, Hongming Yuan, Xigui Ding, Shaofeng Pei, Shixiong Yang, Xue Li, Edward Laws
Faculty Publications
No abstract provided.
Exercise As A Moderator Of Persistent Neuroendocrine Symptoms Of Covid-19, Candida J. Rebello, Christopher L. Axelrod, Charles F. Reynolds, Frank L. Greenway, John P. Kirwan
Exercise As A Moderator Of Persistent Neuroendocrine Symptoms Of Covid-19, Candida J. Rebello, Christopher L. Axelrod, Charles F. Reynolds, Frank L. Greenway, John P. Kirwan
Division of Basic Science Faculty Publications
Precipitated by chronic psychological stress, immune system dysregulation, and a hyperinflammatory state, the sequelae of postacute COVID-19 (long COVID) include depression and new-onset diabetes. We hypothesize that exercise counters the neuropsychiatric and endocrine sequelae of long COVID by inducing the release of circulating factors that mediate the anti-inflammatory response, support brain homeostasis, and increase insulin sensitivity.
Examination Of The Effect Of Plant Induced Defenses On Cannibalistic Consumption And Baculovirus Transmission Amongst Spodoptera Frugiperda Larvae, Paige Elizabeth Long
Examination Of The Effect Of Plant Induced Defenses On Cannibalistic Consumption And Baculovirus Transmission Amongst Spodoptera Frugiperda Larvae, Paige Elizabeth Long
Honors Capstones
No abstract provided.
The Social Boot: Recollections From Another Side A Study On The Health And Belongingness Experiences Of Louisiana Residents That Have Either Served In The Us Military Or Been In The Us Prison System In Some Capacity., Ugonna Njoku
Honors Capstones
No abstract provided.
Pocket2drug: An Encoder-Decoder Deep Neural Network For The Target-Based Drug Design, W T. Shi, M Singha, G Srivastava, L M. Pu, W T. Shi, M Brylinski
Pocket2drug: An Encoder-Decoder Deep Neural Network For The Target-Based Drug Design, W T. Shi, M Singha, G Srivastava, L M. Pu, W T. Shi, M Brylinski
Faculty Publications
Computational modeling is an essential component of modern drug discovery. One of its most important applications is to select promising drug candidates for pharmacologically relevant target proteins. Because of continuing advances in structural biology, putative binding sites for small organic molecules are being discovered in numerous proteins linked to various diseases. These valuable data offer new opportunities to build efficient computational models predicting binding molecules for target sites through the application of data mining and machine learning. In particular, deep neural networks are powerful techniques capable of learning from complex data in order to make informed drug binding predictions. In …
The Herpes Simplex Virus Type-1 (Hsv-1), Vc2 Live-Attenuated Vaccine Strain Induces Robust Antitumor Immune Responses And Ameliorates Intra-Tumor Immunosuppression In An Immunocompetent B16f10-Derived Murine Melanoma Model, Ifeanyi Kingsley Uche
LSU Doctoral Dissertations
Current cancer immunotherapies include immune checkpoint inhibitors, adoptive cellular therapy, and cancer vaccines. While some of these therapies have met with great clinical success, they are associated with several limitations. Oncolytic virotherapy (OVT) has emerged as a bonafide promising immunotherapy, that uses viral infection to liberate tumor antigens in an immunogenic context to promote the development of anti-tumor immune responses. At present, Talimogene laherparepvec (T-VEC; Imlygic™), a modified type 1 herpes simplex virus (HSV-1) is the only FDA approved OVT for human cancer treatment (melanoma). While T-VEC is associated with limited response rates, its modest efficacy supports the continued development …
Fatal Neurodissemination And Sars-Cov-2 Tropism In K18-Hace2 Mice Is Only Partially Dependent On Hace2 Expression, Mariano Carossino, Devin Kenney, Aoife K. O’Connell, Paige Montanaro, Anna E. Tseng, Hans P. Gertje, Kyle A. Grosz, Maria Ericsson, Bertrand R. Huber, Susanna A. Kurnick, Saravanan Subramaniam, Thomas Kirkland, Joel R. Walker, Kevin P. Francis, Alexander D. Klose, Neal Paragas, Markus Bosmann, Mohsan Saeed, Udeni Balasuriya, Florian Douam, Nicholas Crossland
Fatal Neurodissemination And Sars-Cov-2 Tropism In K18-Hace2 Mice Is Only Partially Dependent On Hace2 Expression, Mariano Carossino, Devin Kenney, Aoife K. O’Connell, Paige Montanaro, Anna E. Tseng, Hans P. Gertje, Kyle A. Grosz, Maria Ericsson, Bertrand R. Huber, Susanna A. Kurnick, Saravanan Subramaniam, Thomas Kirkland, Joel R. Walker, Kevin P. Francis, Alexander D. Klose, Neal Paragas, Markus Bosmann, Mohsan Saeed, Udeni Balasuriya, Florian Douam, Nicholas Crossland
Faculty Publications
No abstract provided.
Assessing Influenza Vaccination Coverage And Predictors In Persons Living With Hiv/Aids In Louisiana, June 2002-June 2013, Patrick Maloney, Ariane Rung, Stephanie Broyles, John Couk, Edward Peters, Susanne Straif-Bourgeois
Assessing Influenza Vaccination Coverage And Predictors In Persons Living With Hiv/Aids In Louisiana, June 2002-June 2013, Patrick Maloney, Ariane Rung, Stephanie Broyles, John Couk, Edward Peters, Susanne Straif-Bourgeois
Population and Public Health Science Faculty Publications
Background. Despite the burden of disease and increased risk of influenza-associated morbidity and mortality among PLWHA, influenza vaccination has been understudied in this population. Methods. We built an 11-year cohort of HIV-infected adults from medical records of PLWHA seeking care within the Louisiana State University medical system from June 2002-June 2013. Influenza vaccination uptake among PLWHA was calculated overall and for each medical facility for each influenza season. Linear regression was used to assess influenza vaccination uptake over time, both overall and by facility. Data were restricted to the final influenza season (2012-13) to assess predictors of PLWHA vaccination. Individuals …
New Limit Theorems For Increments Of Birth-And-Death Processes With Linear Rates, Alexander Ya. Kreinin, Vladimir V. Vinogradov
New Limit Theorems For Increments Of Birth-And-Death Processes With Linear Rates, Alexander Ya. Kreinin, Vladimir V. Vinogradov
Journal of Stochastic Analysis
No abstract provided.
Inhibition Of Biotin Carboxylase By Three Antibacterial Compounds, Matt Craft
Inhibition Of Biotin Carboxylase By Three Antibacterial Compounds, Matt Craft
LSU Doctoral Dissertations
The rise of antibacterial resistant bacteria is a major problem in the United States of America and around the world. Millions of patients are infected with antimicrobial resistant bacteria each year. Novel antibacterial agents are needed to combat the growing and present crisis. Acetyl-CoA carboxylase (ACC), the multi-subunit complex which catalyses the first committed step in fatty acid synthesis, is a validated target for antibacterial agents. However, there are at present, no commercially available antibiotics that target ACC. Ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulfonylamino]benzoate (SABA1) is a compound that has been shown to have antibacterial properties against Pseudomonas aeruginosa and Escherichia coli. SABA1 inhibits …
Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc
Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc
Faculty Publications
We provide a new global strict Lyapunov function construction for a susceptible, infected, and recovered (or SIR) disease dynamics that includes quarantine of infected individuals and mass vaccination. We use the Lyapunov function to design feedback controls to asymptotically stabilize a desired endemic equilibrium, and to prove input-to-state stability for the dynamics with a suitable restriction on the disturbances. Our simulations illustrate the potential of our feedback controls to reduce peak levels of infected individuals.
Geographic Analysis Of Alcohol-Related Crashes In Nine High-Need Louisiana Parishes, Aimee H. Moles, Austin L. Matthews, John K. Aggrey, Leanna B. Cupit
Geographic Analysis Of Alcohol-Related Crashes In Nine High-Need Louisiana Parishes, Aimee H. Moles, Austin L. Matthews, John K. Aggrey, Leanna B. Cupit
Reports
This report examines nine Louisiana communities and their alcohol availability concerns from a public health perspective. The nine communities are part of The Louisiana Partnership for Success II (LPFS ll), a 5-year Substance Abuse and Mental Health Services Administration (SAMHSA) grant. The LPFS ll grant is focused exclusively on addressing underage drinking behaviors, consequences, and risk factors among 9 to 20-year-olds in nine high-need, parish-level communities (HNCs) (Louisiana Department of Health [LDH], 2020a). Communities were selected through a data-driven, participatory process and supported to form a cross-sector coalition to implement interventions within those communities. The process for choosing the high-need …
Editorial Introduction: A Very Brief Introduction To The Landscape Of Emerging Infectious Diseases, James Nguyen H. Spencer
Editorial Introduction: A Very Brief Introduction To The Landscape Of Emerging Infectious Diseases, James Nguyen H. Spencer
Faculty Publications
No abstract provided.
The Precision Interventions For Severe And/Or Exacerbation-Prone (Precise) Asthma Network: An Overview Of Network Organization, Procedures, And Interventions, Steve N. Georas, Rosalind J. Wright, Anastasia Ivanova, Elliot Israel, Lisa M. Lavange, Praveen Akuthota, Tara F. Carr, Loren C. Denlinger, Merritt L. Fajt, Rajesh Kumar, Wanda K. O'Neal, Wanda Phipatanakul, Stanley J. Szefler, Mark A. Aronica, Leonard B. Bacharier, Allison J. Burbank, Mario Castro, Laura Crotty Alexander, Julie Bamdad, Juan Carlos Cardet, Suzy A.A. Comhair, Ronina A. Covar, Emily A. Dimango, Kim Erwin, Serpil C. Erzurum, John V. Fahy, Jonathan M. Gaffin, Benjamin Gaston, Lynn B. Gerald, Eric A. Hoffman, Fernando Holguin, Daniel J. Jackson, John James, Nizar N. Jarjour
The Precision Interventions For Severe And/Or Exacerbation-Prone (Precise) Asthma Network: An Overview Of Network Organization, Procedures, And Interventions, Steve N. Georas, Rosalind J. Wright, Anastasia Ivanova, Elliot Israel, Lisa M. Lavange, Praveen Akuthota, Tara F. Carr, Loren C. Denlinger, Merritt L. Fajt, Rajesh Kumar, Wanda K. O'Neal, Wanda Phipatanakul, Stanley J. Szefler, Mark A. Aronica, Leonard B. Bacharier, Allison J. Burbank, Mario Castro, Laura Crotty Alexander, Julie Bamdad, Juan Carlos Cardet, Suzy A.A. Comhair, Ronina A. Covar, Emily A. Dimango, Kim Erwin, Serpil C. Erzurum, John V. Fahy, Jonathan M. Gaffin, Benjamin Gaston, Lynn B. Gerald, Eric A. Hoffman, Fernando Holguin, Daniel J. Jackson, John James, Nizar N. Jarjour
Division of Basic Science Faculty Publications
Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate …
The Effect Of Door Opening On Air-Mixing In A Positively Pressurized Room: Implications For Operating Room Air Management During The Covid Outbreak, Arup Bhattacharya, Ali Ghahramani, Ehsan Mousavi
The Effect Of Door Opening On Air-Mixing In A Positively Pressurized Room: Implications For Operating Room Air Management During The Covid Outbreak, Arup Bhattacharya, Ali Ghahramani, Ehsan Mousavi
Faculty Publications
The effect of the built environment on the predominant indoor airflow patterns is significant. To protect the healthcare workers at the front line from the outbreak of COVID − 19, it is necessary to understand the transmission dynamics of the virus, which has been shown to depend on indoor airflow patterns. In hospital operating rooms (ORs), design requirements pose a unique challenge as the positive pressure in the OR can facilitate virus spread into adjacent spaces, shall a COVID-positive patient require a surgical procedure. Moreover, the turbulent vortexes from door motions could independently increase the probability of virus escape from …
Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Samuel Ajayi, Yemi Raji, Timothy Olanrewaju, Charlotte Osafo, Ifeoma Ulasi, Adanze Asinobi, Cheryl A. Winkler, David Burke, Fatiu Arogundade, Ivy Ekem, Jacob Plange-Rhule, Manmak Mamven
Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Samuel Ajayi, Yemi Raji, Timothy Olanrewaju, Charlotte Osafo, Ifeoma Ulasi, Adanze Asinobi, Cheryl A. Winkler, David Burke, Fatiu Arogundade, Ivy Ekem, Jacob Plange-Rhule, Manmak Mamven
Faculty Publications
Background: The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women. The current analysis examines the association between body composition, defined by body mass index (BMI), height, and weight, and BC by molecular subtype among African women. Methods: We estimated odds ratios (ORs) and 95% confidence intervals …